WO2010002427A2 - Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor - Google Patents

Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor Download PDF

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Publication number
WO2010002427A2
WO2010002427A2 PCT/US2009/003347 US2009003347W WO2010002427A2 WO 2010002427 A2 WO2010002427 A2 WO 2010002427A2 US 2009003347 W US2009003347 W US 2009003347W WO 2010002427 A2 WO2010002427 A2 WO 2010002427A2
Authority
WO
WIPO (PCT)
Prior art keywords
distance
laser sensor
collection instrument
actual
positional relationship
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/003347
Other languages
English (en)
French (fr)
Other versions
WO2010002427A3 (en
Inventor
Gary L. Van Berkel
Vilmos Kertesz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UT Battelle LLC
Original Assignee
UT Battelle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UT Battelle LLC filed Critical UT Battelle LLC
Priority to CA2729701A priority Critical patent/CA2729701C/en
Priority to JP2011516271A priority patent/JP5710473B2/ja
Priority to EP09773880.1A priority patent/EP2304766B1/en
Publication of WO2010002427A2 publication Critical patent/WO2010002427A2/en
Publication of WO2010002427A3 publication Critical patent/WO2010002427A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples

Definitions

  • the method of the invention includes the steps carried out by the system of the invention.
  • steps include the generating of a signal with the distance-measuring means which corresponds to the actual distance between the laser sensor and the surface and determining the actual distance between the laser sensor and the surface from the signal generated by the distance- generating means.
  • the actual distance between the laser sensor and the surface is compared to the target distance, and movement of the surface and the laser sensor toward or away from one another is initiated when the difference between the actual distance between the laser sensor and the surface and the target distance is outside of a predetermined range so that by moving the surface and the laser sensor toward or away from one another, the actual distance approaches the desired target distance.
  • Fig. 1 is a schematic view of the system 20 within with features of the present invention are incorporated .
  • Fig. 4a is a view illustrating schematically an exemplary positional relationship between the laser sensor, the sample collection instrument and the surface of the Fig. 1 system seen generally from the front.
  • Fig. 5c is a view similar to that of Fig. 5a except that the components are positioned in another non- optimal relationship for sample collecting purposes.
  • the support plate 27 is, in turn, supportedly mounted upon the movable support arm 36 of an XYZ stage 28 (Fig. 1), for movement of the support plate 27, and the surface 22 supported thereby, along the indicated X, Y and Z coordinate directions.
  • the XYZ stage 28 is appropriately wired to a joystick control unit 29 which is, in turn, connected to a first control computer 30 for receiving command signals therefrom so that during a sampling process performed with the system 20, samples can be taken from any desired spot (i.e. any desired X-Y coordinate location) along the surface 22 or along any desired lane (i.e. along an X or Y-coordinate path) across the surface 22 as the surface 22 is moved within the X-Y plane beneath the collection tube tip 26.
  • the system 20 automates the formulation of real-time re-optimization of the sample collection instrument-to-surface distance using distance measurements obtained with a laser sensor 42.
  • the distance measurement analysis includes the periodic measurement of the actual distance between the laser sensor 42 and the surface 22 followed by a comparison of each of the measured actual laser sensor-to-surface distances to a target laser sensor- to-surface distance.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Electron Tubes For Measurement (AREA)
PCT/US2009/003347 2008-07-02 2009-06-02 Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor Ceased WO2010002427A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2729701A CA2729701C (en) 2008-07-02 2009-06-02 Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor
JP2011516271A JP5710473B2 (ja) 2008-07-02 2009-06-02 サンプリング手順における試料収集機器と被分析表面の位置関係のレーザ・センサを使用した制御
EP09773880.1A EP2304766B1 (en) 2008-07-02 2009-06-02 Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/217,225 2008-07-02
US12/217,225 US8117929B2 (en) 2008-07-02 2008-07-02 Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor

Publications (2)

Publication Number Publication Date
WO2010002427A2 true WO2010002427A2 (en) 2010-01-07
WO2010002427A3 WO2010002427A3 (en) 2010-02-25

Family

ID=41327314

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/003347 Ceased WO2010002427A2 (en) 2008-07-02 2009-06-02 Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure using a laser sensor

Country Status (5)

Country Link
US (1) US8117929B2 (enExample)
EP (1) EP2304766B1 (enExample)
JP (1) JP5710473B2 (enExample)
CA (1) CA2729701C (enExample)
WO (1) WO2010002427A2 (enExample)

Cited By (1)

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CN116218649A (zh) * 2022-12-30 2023-06-06 德诺杰亿(北京)生物科技有限公司 基因分析仪上样台的自动校准方法、装置及基因分析仪

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US8766177B2 (en) * 2010-10-11 2014-07-01 University Of North Texas Nanomanipulation coupled nanospray mass spectrometry (NMS)
JP2012237557A (ja) * 2011-05-09 2012-12-06 Shimadzu Corp 液体試料採取装置及び液体試料採取方法
US9176028B2 (en) 2012-10-04 2015-11-03 Ut-Battelle, Llc Ball assisted device for analytical surface sampling
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
US9632066B2 (en) 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
WO2017181394A1 (zh) * 2016-04-21 2017-10-26 深圳市樊溪电子有限公司 一种油气包裹体成分取样方法
US11125657B2 (en) 2018-01-30 2021-09-21 Ut-Battelle, Llc Sampling probe
WO2020242911A1 (en) * 2019-05-31 2020-12-03 Purdue Research Foundation Integrated microfluidic probe (imfp) and methods of use thereof
DE102021128848B4 (de) 2021-11-05 2025-08-07 Bruker Daltonics GmbH & Co. KG Vorrichtung zum desorbierenden Abtasten von Analytmaterial auf einem Probenträger
CN118857839B (zh) * 2024-09-25 2024-12-06 大连馨士俐科技服务有限公司 一种用于市政道路施工质量检测的取芯装置

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JPH0687003B2 (ja) * 1990-02-09 1994-11-02 株式会社日立製作所 走査型トンネル顕微鏡付き走査型電子顕微鏡
JPH04162337A (ja) * 1990-10-24 1992-06-05 Hitachi Ltd 電子線装置
DE4116803A1 (de) * 1991-05-23 1992-12-10 Agfa Gevaert Ag Vorrichtung zur gleichmaessigen ausleuchtung einer projektionsflaeche
US5196713A (en) * 1991-08-22 1993-03-23 Wyko Corporation Optical position sensor with corner-cube and servo-feedback for scanning microscopes
JP3015980B2 (ja) * 1992-01-10 2000-03-06 キヤノン株式会社 原子間力顕微鏡及び記録再生装置及び再生装置
JP2002175770A (ja) * 2000-12-08 2002-06-21 Hitachi Ltd 気体排気用試料室及びそれを用いた回路パターン形成装置
GB0112903D0 (en) * 2001-05-26 2001-07-18 Univ Heriot Watt Permeability measurement apparatus and method
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JP4427824B2 (ja) 2003-09-03 2010-03-10 日立建機株式会社 プローブの製造方法、プローブおよび走査型プローブ顕微鏡
US20080033275A1 (en) * 2004-04-28 2008-02-07 Blank Thomas B Method and Apparatus for Sample Probe Movement Control
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US7295026B2 (en) * 2005-06-03 2007-11-13 Ut-Battelle, Llc Automated position control of a surface array relative to a liquid microjunction surface sampler

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116218649A (zh) * 2022-12-30 2023-06-06 德诺杰亿(北京)生物科技有限公司 基因分析仪上样台的自动校准方法、装置及基因分析仪

Also Published As

Publication number Publication date
CA2729701C (en) 2015-11-03
JP2011527075A (ja) 2011-10-20
JP5710473B2 (ja) 2015-04-30
WO2010002427A3 (en) 2010-02-25
EP2304766A2 (en) 2011-04-06
CA2729701A1 (en) 2010-01-07
US20100000338A1 (en) 2010-01-07
US8117929B2 (en) 2012-02-21
EP2304766B1 (en) 2019-07-31

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