WO2009139167A1 - Composition de nutriments capable d’ajuster la quantité d’énergie, la quantité d’eau et l’équivalent de sel - Google Patents

Composition de nutriments capable d’ajuster la quantité d’énergie, la quantité d’eau et l’équivalent de sel Download PDF

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Publication number
WO2009139167A1
WO2009139167A1 PCT/JP2009/002107 JP2009002107W WO2009139167A1 WO 2009139167 A1 WO2009139167 A1 WO 2009139167A1 JP 2009002107 W JP2009002107 W JP 2009002107W WO 2009139167 A1 WO2009139167 A1 WO 2009139167A1
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Prior art keywords
amount
nutritional composition
kcal
water
nutritional
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PCT/JP2009/002107
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English (en)
Japanese (ja)
Inventor
海野弘之
麻生高伸
溝口克典
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明治乳業株式会社
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Priority to JP2009550844A priority Critical patent/JP5160569B2/ja
Priority to CN200980117020.4A priority patent/CN102026661B/zh
Publication of WO2009139167A1 publication Critical patent/WO2009139167A1/fr
Priority to HK11110070.9A priority patent/HK1155672A1/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a nutritional composition used for enteral nutrition that can adjust the amount of energy, the amount of water, and the amount converted into salt.
  • Nutrition therapy is used by patients, infants, the elderly and care recipients who have impaired digestive function to provide nutrients when food intake is inadequate or impossible. Intestinal nutrition therapy is widely used as a safer and less expensive nutrition therapy than parenteral nutrition. This is because the central parenteral nutrition method does not go through the digestive tract, causing metabolic complications such as abnormal sugar metabolism, digestive tract complications such as atrophy of the digestive tract mucosa, and catheter-related infections. Because. Therefore, in recent years, the principle of selecting enteral nutrition rather than central parenteral nutrition is being established if the digestive system is functioning.
  • enteral nutrition is a safe and low-cost nutritional therapy widely used by many patients, infants, the elderly and care recipients, and is used as a food or medicine for various enteral nutrition.
  • a fluid nutrition composition (hereinafter also referred to as “liquid food”) is commercially available.
  • liquid food which mix
  • the typical patent document in which the formulation example of a liquid food is disclosed is illustrated below.
  • JP 2002-142720 Japanese Patent Laid-Open No. 2004-05494 JP 2004-077564 A
  • liquid foods for enteral nutrition and liquid foods in the above-mentioned patent documents are designed mainly from the viewpoint of the amount of energy and the concentration of various nutritional components. It is necessary to adjust the amount of energy for one serving, the amount of water, and the amount of sodium converted to sodium chloride (salt) amount according to the state of the meal. It was necessary to calculate the contents of water, sodium, and the like as a standard, and add the deficiency to the liquid food to adjust it before administration.
  • the addition of water is performed by directly adding hot water to a liquid food container and mixing, or by mixing liquid food and hot water in a container separate from the liquid food container, etc.
  • sodium chloride is added by dissolving the sodium chloride in water and then adding this solution to a liquid food and mixing it, or administering the solution to a tube feeding tube with a syringe, etc. Has been done. And those who are engaged in nursing care or nursing need to perform these operations three times a day, and even for liquid foods of the same prescription for the same person for each meal, the operator repeats the same work There is a very inefficient current situation.
  • liquid food for enteral nutrition method the formulation is designed from the viewpoint of the amount of energy and the concentration of each nutritional component as described above, and the amount of water and salt equivalent is fractional. There is also a possibility that the calculation is difficult to make and is wrong. Furthermore, in general, liquid food is administered for several hours continuously, and the liquid food once opened by the above-described operation of adding water and sodium chloride may be contaminated by microorganisms and is hygienic. Problems also arise.
  • the present inventor unexpectedly pays attention to problems that have been overlooked so far, and has the optimum energy amount, water amount, salt conversion amount, etc. according to the conditions of various people such as patients.
  • the purpose of the present invention is to provide means that can eliminate the work of adding water, sodium chloride, etc. to a liquid food, and can solve the problem of contamination during preparation, by developing means that can prepare food easily and quickly. To do.
  • two kinds of nutrients, water and sodium that are energy sources are substantially the same as each other, but have different contents of one or more ingredients selected from nutrients, water, and sodium that are energy sources.
  • the present inventors have completed the present invention.
  • the present invention is a nutritional composition containing nutrients, water and sodium as energy sources, and by combining with one or more other nutritional compositions, the amount of energy, water content and salt converted amount after combination
  • the nutritional composition to be adjusted contains substantially the same components as all the nutritional compositions to be combined, but one or more of the nutritional compositions to be combined are composed of nutrients, water and sodium as energy sources. It is related with the said nutrition composition in which the content of the 1 or more types of component chosen differs.
  • the present invention also relates to the nutritional composition, wherein the nutritional amount of the nutritional composition is an integral multiple of 5 kcal, the water content is an integral multiple of 5 ml, and the salt equivalent is an integral multiple of 0.25 g.
  • the present invention relates to the nutritional composition, wherein the nutritional composition has an energy amount of 100 to 600 kcal, a water content of 100 to 800 ml, and a salt equivalent amount of 0.25 to 4.5 g.
  • the present invention also provides the nutritional amount of energy, water content and salt equivalent amount of 300 kcal, 300 ml and 1.0 g, 300 kcal, 400 ml and 1.5 g, 300 kcal, 500 ml and 2.0 g, 400 kcal, 400 ml and It relates to said nutritional composition which is 1.5 g, 400 kcal, 500 ml and 2.0 g, or 400 kcal, 600 ml and 2.5 g.
  • this invention relates to the said nutrition composition whose nutrient as an energy source is 1 or more types chosen from the group which consists of lipid, protein, carbohydrate, and those hydrolysates. Moreover, this invention relates to the said nutrition composition which contains minerals other than a vitamin and / or sodium as a component which adjusts content.
  • the present inventor has formulated and designed the conventional nutritional composition so that the amount of energy relative to the amount of water exceeds 1.0 kcal / ml, and the amount of water required by bedridden elderly people with low physical activity levels.
  • the present invention also relates to the nutritional composition, wherein the energy content of the nutritional composition relative to the amount of water is 0.5 to 1.0 kcal / ml.
  • the present inventor has formulated and designed the conventional nutritional composition so that the amount of salt converted to the amount of energy is less than 0.25 g / 100 kcal, which is necessary for bedridden elderly people with low physical activity levels, etc. Focusing on the fact that the balance between the amount of energy and the amount converted into salt is different, and simultaneously developed the invention of a nutritional composition that has the optimum balance between the amount of energy and the amount converted into salt that is suitable for the physical activity level of the bedridden elderly did. Accordingly, the present invention also relates to the nutritional composition, wherein the amount of sodium chloride relative to the amount of energy of the nutritional composition is 0.25 to 1.0 g / 100 kcal.
  • the present inventor can administer the nutritional composition to a patient with minimal contact with the outside air by placing the nutritional composition in a sealed container, further reducing the possibility of contamination of the nutritional composition. Focusing on what can be done, the invention of the nutritional composition in a container in a sealed container was completed at the same time. Therefore, this invention relates also to the nutrition composition in a container which put the said nutrition composition in the airtight type container.
  • this invention relates to the kit of the nutrition composition in a container containing the said nutrition composition in a container by 2 or more types. Furthermore, this invention relates to the method of adjusting the energy amount, moisture content, and salt conversion amount of the nutrition composition after a combination by combining the said nutrition composition or nutrition composition in a container with 2 or more types.
  • a nutrient composition containing nutrients, water, and sodium as energy sources, including substantially the same components as each other, but having different contents of at least one component selected from nutrients, water, and sodium as energy sources
  • a nutrient composition containing nutrients, water, and sodium as energy sources, including substantially the same components as each other, but having different contents of at least one component selected from nutrients, water, and sodium as energy sources
  • the nutritional composition is a nutritional composition used for enteral nutrition, and is a food or a medicine.
  • the enteral nutrition method includes an oral intake method in which nutrition is supplied from the mouth and a tube feeding method in which administration is performed using a tube, and is typically a tube feeding method.
  • tube feeding includes oral, nasal and vaginal methods.
  • the nutritional composition of the present invention is in the form of a liquid, fluid, jelly or paste, and is typically a liquid or fluid.
  • the use form which concentrates or dries the nutritional composition to powder or solid and adds water at the time of use to make liquid or fluid may be used.
  • the classification of the nutritional composition includes ingredient nutrients, digested liquid foods or digestive nutrients, semi-digested liquid foods or semi-digested nutrients, natural concentrated liquid foods, etc. Liquid diet or digestive nutrient, or semi-digested fluid or semi-digestible nutrient.
  • the term “combination” refers to the combination of the nutritional composition of the present invention as a single substance, and the nutritional composition obtained by combining and mixing a part of the nutritional composition as a single substance and / or as a simple substance. It is meant to be combined with a part of the composition.
  • the nutritional composition in which the amount of energy, the amount of water and the amount in terms of salt are adjusted may be administered as a single serving of each nutritional composition to be combined, After the two or more kinds of nutritional compositions are mixed with each other, all or part of the mixed nutritional composition may be administered as a serving.
  • the other one or more nutritional compositions to be combined contain substantially the same ingredients as each other means that the two or more nutritional compositions to be combined contain the same ingredients or the same as each other. It includes ingredients that adjust the content by combining them, and further includes other ingredients that are different from each other.
  • the number of other one or more nutritional compositions to be combined is, for example, 1 to 5 from the viewpoint that the combined nutritional composition can be used for various prescriptions. In consideration of the above, it is preferably 1 to 4, more preferably 1 to 3.
  • the amount of energy is preferably 5 kcal, 10 kcal, from the viewpoint that the energy amount of the nutritional composition after combination can correspond to various prescriptions and the calculation of the energy amount is easy. It is an integer multiple of 25 kcal, 50 kcal, or 100 kcal, and from the viewpoint of reducing the number of varieties, it is more preferably an integer multiple of 25 kcal, 50 kcal, or 100 kcal, and particularly preferably an integer multiple of 50 kcal or 100 kcal.
  • the water content is preferably 5 ml from the viewpoint that the water content of the nutritional composition after combination can correspond to various formulations and the calculation of the water content is easy. It is an integer multiple of 10 ml, 25 ml, 50 ml or 100 ml. From the viewpoint of reducing the number of varieties, it is more preferably an integer multiple of 25 ml, 50 ml or 100 ml, and particularly preferably an integer multiple of 50 ml or 100 ml.
  • the amount in terms of salt is a numerical value obtained by converting the amount of sodium contained in the nutritional composition into the amount of sodium chloride (salt).
  • the salt equivalent amount is preferably from the viewpoint that the salt equivalent amount of the nutritional composition after combination can correspond to various prescriptions and the calculation of the salt equivalent amount is easy. Is an integer multiple of 0.25 g, 0.5 g, 1.0 g, or 2.5 g, and more preferably an integer multiple of 0.25 g, 0.5 g, or 1.0 g from the viewpoint of reducing the number of varieties. Particularly preferred is an integer multiple of 0.5 g or 1.0 g.
  • the amount of energy, the amount of water and the amount converted into salt can be combined with various formulas for the energy amount, the amount of water and the amount converted into salt after the combination, and calculation is easy.
  • the amount of energy, the amount of water and the amount converted to salt are preferably in the range of 100 kcal to 600 kcal, 100 ml to 800 ml, and 0.25 g to 4.5 g, more preferably 200 kcal to 500 kcal, respectively.
  • the amount of energy, the amount of water and the amount converted into salt are also compatible with various formulations.
  • the amount of energy, the amount of water, and the amount in terms of salt are 300 kcal, 300 ml and 0.5 g, 300 kcal, 300 ml and 1.0 g, 300 kcal, 400 ml, respectively.
  • the range of energy amount, water amount and salt equivalent amount of the prescription is not necessarily clear, but generally the energy amount is in the range of 600 to 2000 kcal. Since the amount of water is in the range of 600 to 2000 ml and the amount in terms of salt is in the range of 3 to 12 g, the actual clinical site etc. can be obtained by combining two or more nutritional compositions formulated as described above. Can handle most of the prescriptions required in
  • the ingredients for adjusting the content include nutrients serving as energy sources, water, sodium, vitamins, minerals other than sodium, and dietary fiber, and typically nutrients serving as energy sources, water, and sodium. It is. Examples of nutrients that serve as energy sources include lipids, proteins, carbohydrates, and hydrolysates thereof. Details of these components will be described later.
  • the amount of energy relative to the moisture content of the nutritional composition is preferably 0.5 to 1.0 kcal / in consideration of the level of physical activity of the patient or the like to which the nutritional composition of the present invention is administered. ml, more preferably 0.5 to 0.9 kcal / ml, and particularly preferably 0.5 to 0.8 kcal / ml. In bedridden elderly people to whom enteral nutrition is applied, since the level of physical activity is low, it is necessary to reduce the amount of energy relative to the water content of the nutritional composition, and in the range of 0.5 to 1.0 kcal / ml If so, problems such as dehydration due to insufficient water intake and urinary tract infections due to a decrease in urine volume can be prevented.
  • the amount in terms of salt relative to the amount of energy of the nutritional composition is preferably 0.25 to 1.0 g in consideration of the necessary calorie of the patient to whom the nutritional composition of the present invention is administered. / 100 kcal, more preferably 0.35 to 1.0 g / 100 kcal, and particularly preferably 0.45 to 1.0 g / 100 kcal.
  • the amount of heat required is small, so it is necessary to increase the amount in terms of salt relative to the amount of energy, and if it is in the range of 0.25 to 1.0 g / 100 kcal, Problems such as hyponatremia due to urine concentration ability can be prevented.
  • the hermetically sealed container means a hermetically sealed container (closed pack) for shutting off the nutritional composition as the contents and the outside world, and the form of the container is typically a pack or a retort.
  • Examples include pouches, soft bags, regular containers and cans, and packs, retort pouches, soft bags, regular containers and the like are preferable.
  • Typical examples of the material of the container include paper, plastic, glass and metal, and preferably paper, plastic and metal.
  • the container may be provided with one or two or more narrow mouth portions for spilling and / or mixing, and the narrow mouth portion is sealed before use, and a nutritional composition is administered at the time of use.
  • You may provide the mechanism which can be directly connected to the narrow mouth part of the tube or the container of another nutrition composition.
  • the nutritional composition kit means a nutritional composition kit for use in enteral nutrition, comprising two or more nutritional compositions in a container of the present invention.
  • a tube for tube feeding, a stopcock, a syringe, a connection adapter, and the like may be included.
  • Two or more kinds of nutritional compositions in containers included in the kit can be combined with two or more kinds of nutritional compositions in containers of a specific formulation so that they can appropriately respond to most prescriptions required in clinical settings.
  • a group of nutritional compositions contained in a container may be included, and a plurality of groups of nutritional compositions contained in the container may be included.
  • the number of varieties of the nutritional composition contained in the kit included in the kit is, for example, 1 to 18 types from the viewpoint that the nutritional composition contained in the container after combination can cope with various prescriptions, and calculation is easy. From the viewpoint of reducing the number of varieties and the like, it is preferably 1 to 12 types, more preferably 1 to 6 types.
  • the blending of energy amount, moisture amount and salt equivalent amount is (A) 300 kcal, 300 ml and 1.0 g, and (B) 300 kcal, 400 ml and 1.
  • the sodium, lipid, protein, carbohydrate, vitamin, mineral and the like to be blended in the nutritional composition of the present invention are not particularly limited as long as they are usually used in the field of food and beverages and pharmaceuticals, It is preferable to use those approved by the Ministry of Health, Labor and Welfare as raw materials and additives for foods and pharmaceuticals.
  • the amount of each nutrient can be determined in accordance with, for example, “Japanese dietary intake standards (2005 version)” formulated by the Ministry of Health, Labor and Welfare.
  • blended with the nutrition composition of this invention is shown below.
  • Sodium sources of the nutritional composition of the present invention include sodium acetate, sodium chloride, sodium citrate, sodium hydroxide, sodium carbonate, sodium bicarbonate, monosodium hydrogen phosphate, disodium hydrogen phosphate, sodium metaphosphate, Examples thereof include sodium pyrophosphate and sodium tripolyphosphate, preferably sodium chloride and sodium citrate. Moreover, you may use these sodium supply sources by 1 or more types. Examples of the water used in the nutritional composition of the present invention include pure water, purified water, and ion exchange water.
  • Lipids to be blended in the nutritional composition of the present invention include vegetable oils such as soybean oil, palm oil, palm fractionation oil and olive oil, animal fats such as milk fat, pork fat and fish oil, and oleic acid, linolenic acid and Examples include free fatty acids such as ⁇ -linolenic acid, preferably soybean oil and palm oil.
  • vegetable oils such as soybean oil, palm oil, palm fractionation oil and olive oil
  • animal fats such as milk fat, pork fat and fish oil
  • oleic acid linolenic acid
  • free fatty acids such as ⁇ -linolenic acid, preferably soybean oil and palm oil.
  • the amount of lipid blended is preferably in the range of 0 to 4%, more preferably in the range of 2.2 to 3.3%. From the viewpoint of the average intake of healthy Japanese, It is in the range of 0 to 30% of the total energy amount of the composition, and more preferably in the range of 20 to 25%.
  • Examples of the protein blended in the nutritional composition of the present invention include vegetable proteins such as soybean protein, animal proteins such as casein and whey protein, and preferably soybean protein, casein and whey protein. In addition, hydrolysates of these proteins may be used, and one or more of these proteins and hydrolysates thereof may be used.
  • the amount of protein blended is preferably in the range of 2 to 10%, more preferably in the range of 3 to 6.5%. From the viewpoint of the average intake of healthy Japanese, preferably the nutritional composition Is in the range of 12 to 40% of the total energy amount, and more preferably in the range of 16 to 25%.
  • Examples of the carbohydrate to be blended in the nutritional composition of the present invention include dextrin, sucrose, lactose and oligosaccharide, and preferably dextrin, sucrose and palatinose. Moreover, you may use the hydrolyzate etc. of these carbohydrates, and you may use these carbohydrates, hydrolyzate, etc. by 1 or more types.
  • the amount of the carbohydrate is preferably in the range of 5 to 20%, more preferably in the range of 10 to 15%. From the viewpoint of the average intake of healthy Japanese, the total amount of the nutritional composition is preferably It is in the range of 20 to 80% of the energy amount, and more preferably in the range of 40 to 60%.
  • Vitamins to be blended in the nutritional composition of the present invention include vitamin A, vitamin D, vitamin E, vitamin B 1 , vitamin B 2 , niacin, vitamin B 6 , folic acid, vitamin B 12 , pantothenic acid and vitamin C.
  • vitamin B 1 , vitamin B 2 , niacin, vitamin B 6 , folic acid, vitamin B 12 , pantothenic acid, vitamin C and the like can be mentioned.
  • minerals other than sodium to be blended in the nutritional composition of the present invention include calcium, iron, phosphorus, magnesium, potassium, copper and zinc, preferably calcium, phosphorus, magnesium and potassium. Moreover, you may use these minerals by 1 or more types.
  • the nutritional composition of the present invention may contain dietary fiber.
  • water-soluble dietary fiber include indigestible dextrin and reduced indigestible dextrin
  • examples of water-insoluble dietary fiber include cellulose. Etc.
  • the nutritional composition of the present invention can contain various flavors, sweeteners and other additives.
  • the pH of the nutritional composition of the present invention is preferably in the range of pH 3 to 11, more preferably in the range of 4 to 10, still more preferably in the range of 5 to 9, from the viewpoint of flavor and physical properties. , Substantially seven.
  • the osmotic pressure of the nutritional composition of the present invention is preferably in the range of 200 to 800 mOsm / L, more preferably 300 to 750 mOsm / L, from the viewpoint of preventing digestive symptoms such as diarrhea and abdominal pain due to high osmotic pressure. Range.
  • the viscosity thereof is preferably in the range of 3 to 40 mPa ⁇ s in room temperature measurement, more preferably 5 m, from the viewpoint of use in tube feeding. It is in the range of ⁇ 20 mPa ⁇ s.
  • the nutritional composition of the present invention can be prepared according to a conventional method known in the art. For example, each component is weighed, mixed well with water, and then emulsified, and the nutritional composition is preliminarily heat sterilized and then aseptically filled into a container (for example, UHT sterilization method and aseptic packaging method) Or a method in which the nutritional composition is filled in a container and then sterilized by heating with the container (for example, an autoclave method).
  • Example 1 Each raw material so that the amount of energy is 300 kcal, and the amount of water and salt equivalent are 300 ml and 1.0 g for A type, 400 ml and 1.5 g for B type, and 500 ml and 2.0 g for C type, respectively.
  • the formulation of was designed. Each component was put into pure water at about 60 ° C. and mixed, and then the mixed solution was put into a homomixer and roughly emulsified at about 5000 rpm for 10 minutes. Subsequently, after heating to 90 degreeC and leaving still for 5 minutes, fine emulsification (20 kgf / cm ⁇ 2 >) was performed with the high pressure emulsifier.
  • the obtained emulsified liquid was cooled to about 20 ° C., vitamins, minerals and flavors were added, and the volume was increased to obtain AC fluid type nutritional compositions.
  • Table 1 below shows formulation examples of the A to C type nutritional compositions to be combined with each other as formulation examples of Example 1.
  • Table 2 below shows raw material composition examples of the above-described A to C type nutritional compositions combined with each other as raw material composition examples of Example 1.
  • Example 2 Each raw material so that the amount of energy is 400 kcal, the amount of water and the amount of salt converted are 400 ml and 1.5 g for D type, 500 ml and 2.0 g for E type, and 600 ml and 2.5 g for F type, respectively.
  • the formulation of was designed. Preparations were made in the same manner as the A to C types to obtain D to F type fluid nutritional compositions. Table 3 below shows formulation examples of D to F type nutritional compositions to be combined with each other as formulation examples of Example 2.
  • Table 4 below shows raw material composition examples of the above D to F type nutritional compositions combined with each other as raw material composition examples of Example 2.
  • the energy amount, water content and salt equivalent amount of the nutritional composition after the combination are optimally adjusted, such as for patients who are required in clinical settings.
  • the administration method using the nutritional composition of the conventional product (unit energy amount: 1 kcal / ml) is referred to as Comparative Examples 1 to 6, and the administration method in which two or more of the A to F type nutritional compositions are combined is described in Example 3 to It was set to 8.
  • the comparison results are shown in Table 6 below.
  • Table 7 shows an example of an administration pattern in which the amount of energy, the amount of water and the amount converted into salt are adjusted by combining the A to F type nutritional compositions.
  • the energy amount is 800 to 1200 kcal
  • the water amount is 800 to 1800 ml
  • the salt equivalent is 3.0 to 7.5 g depending on the administration pattern in which the six types of nutritional compositions A to F are combined. It can be seen that it can be adjusted to a very wide range.
  • the range of energy amount, water amount and salt equivalent amount of the prescription is not necessarily clear, but in general, the energy amount is in the range of 600 to 2000 kcal, Since the amount of water is in the range of 600 to 2000 ml and the amount in terms of salt is in the range of 3 to 12 g, it can be obtained in an actual clinical setting by combining two or more nutritional compositions of the A to F types. It can be seen that most prescriptions can be handled.
  • two or more kinds of nutritional compositions containing nutrients, water and sodium as energy sources and having substantially the same components but different contents are prepared in advance.
  • the energy content, water content and salt equivalent amount of the nutritional composition after combination can be freely designed and adjusted at the same time, so water and sodium can be adjusted according to the patient's prescription. It is possible to save labor by eliminating the work of calculating the daily required amount and adding it to the nutritional composition, and greatly reduce the possibility of contamination during preparation of the nutritional composition, This is particularly useful in medical institutions such as hospitals, welfare facilities such as childcare facilities and nursing care facilities.

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Abstract

La présente invention concerne un procédé permettant d’omettre une opération d’ajout d’eau, de chlorure de sodium ou similaire à une composition de nutriments et de résoudre le problème de contamination après la préparation en développant un procédé permettant de préparer simplement et rapidement une composition de nutriments ayant la quantité d’énergie, la quantité d’eau, la quantité de sodium, etc., les plus appropriées en fonction des conditions de différentes personnes. Une composition de nutriments ayant une formulation optimale peut être préparée simplement et rapidement en combinant deux compositions de nutriments ou plus qui contiennent un nutriment servant de source d’énergie, de l’eau et du sodium, dans lesquelles les teneurs des composants respectifs sont différentes bien qu’elles contiennent sensiblement les mêmes composants, pour concevoir librement la formulation en termes de, par exemple, quantité d’énergie, quantité d’eau, quantité de sodium, etc., de la composition de nutriments après combinaison de celles-ci.
PCT/JP2009/002107 2008-05-15 2009-05-14 Composition de nutriments capable d’ajuster la quantité d’énergie, la quantité d’eau et l’équivalent de sel WO2009139167A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009550844A JP5160569B2 (ja) 2008-05-15 2009-05-14 エネルギー量、水分量および食塩換算量を調整できる栄養組成物
CN200980117020.4A CN102026661B (zh) 2008-05-15 2009-05-14 能够调整能量、含水量及食盐换算量的营养组合物
HK11110070.9A HK1155672A1 (en) 2008-05-15 2011-09-23 Nutrient composition capable of adjusting energy amount, water amount and salt equivalent

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JP2008128521 2008-05-15
JP2008-128521 2008-05-15

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WO2009139167A1 true WO2009139167A1 (fr) 2009-11-19

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WO2014003116A1 (fr) * 2012-06-28 2014-01-03 株式会社明治 Composition nutritionnelle
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JPWO2016104671A1 (ja) * 2014-12-26 2017-10-05 株式会社明治 食物繊維を含む補充液

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JP5160569B2 (ja) 2013-03-13
JP5404558B2 (ja) 2014-02-05
JP2010275318A (ja) 2010-12-09
JPWO2009139167A1 (ja) 2011-09-15
CN102026661A (zh) 2011-04-20

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