WO2009137624A3 - Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables - Google Patents

Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables Download PDF

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Publication number
WO2009137624A3
WO2009137624A3 PCT/US2009/043043 US2009043043W WO2009137624A3 WO 2009137624 A3 WO2009137624 A3 WO 2009137624A3 US 2009043043 W US2009043043 W US 2009043043W WO 2009137624 A3 WO2009137624 A3 WO 2009137624A3
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WIPO (PCT)
Prior art keywords
cells
hemangio
colony forming
engrafting
preparations
Prior art date
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PCT/US2009/043043
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English (en)
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WO2009137624A2 (fr
Inventor
Robert Lanza
Shi-Jiang Lu
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Advanced Cell Technology, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020167023332A priority Critical patent/KR101923290B1/ko
Priority to EP09743610A priority patent/EP2291513A4/fr
Application filed by Advanced Cell Technology, Inc. filed Critical Advanced Cell Technology, Inc.
Priority to US12/991,096 priority patent/US9410123B2/en
Priority to EP18182514.2A priority patent/EP3441462A1/fr
Priority to JP2011508644A priority patent/JP2011519576A/ja
Priority to AU2009244231A priority patent/AU2009244231B2/en
Priority to BRPI0912201A priority patent/BRPI0912201A2/pt
Priority to MX2010012088A priority patent/MX2010012088A/es
Priority to EP13180755.4A priority patent/EP2712921B1/fr
Priority to CN2009801258605A priority patent/CN102083963A/zh
Priority to KR1020187033531A priority patent/KR20180127528A/ko
Priority to CA2722693A priority patent/CA2722693C/fr
Publication of WO2009137624A2 publication Critical patent/WO2009137624A2/fr
Publication of WO2009137624A3 publication Critical patent/WO2009137624A3/fr
Priority to US15/203,639 priority patent/US20170152481A1/en
Priority to US16/690,888 priority patent/US20200157503A1/en

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Abstract

La présente invention concerne des procédés de génération et de multiplication de cellules formant des colonies hémangioblastiques humaines et de cellules hémangioblastiques non transplantables in vitro, ainsi que des procédés de multiplication et d'utilisation desdites cellules. Ces procédés permettent la production d'un grand nombre de cellules formant des colonies hémangioblastiques, de cellules hémangioblastiques non transplantables, ainsi que de cellules dérivées, telles que des cellules hématopoïétiques et endothéliales. Les cellules obtenues par les procédés de l'invention peuvent être utilisées pour diverses applications cliniques, thérapeutiques et de recherche. Les cellules hémangioblastiques non transplantables constituent une population inédite de cellules progénitrices proches, mais distinctes, des hémangioblastes et des cellules formant des colonies hémangioblastiques humaines. L'invention concerne également des compositions, des préparations et des solutions comprenant des cellules formant des colonies hémangioblastiques, des cellules hémangioblastiques non transplantables ou des cellules différenciées à partir des précédentes. Lesdites compositions, préparations et solutions comprennent des préparations cryoconservées et des préparations essentiellement purifiées, ainsi que des compositions mixtes dans lesquelles lesdites cellules de l'invention sont associées à des types de cellules progénitrices hémangioblastiques qui peuvent être transplantées dans la moelle osseuse.
PCT/US2009/043043 2008-05-06 2009-05-06 Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables WO2009137624A2 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
EP13180755.4A EP2712921B1 (fr) 2008-05-06 2009-05-06 Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables
MX2010012088A MX2010012088A (es) 2008-05-06 2009-05-06 Celulas que forman colonias de hemangiomas y celulas de hemangioma sin injertar.
US12/991,096 US9410123B2 (en) 2008-05-06 2009-05-06 Hemangio colony forming cells and non-engrafting hemangio cells
EP09743610A EP2291513A4 (fr) 2008-05-06 2009-05-06 Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables
JP2011508644A JP2011519576A (ja) 2008-05-06 2009-05-06 血管コロニー形成細胞および非生着血管細胞
AU2009244231A AU2009244231B2 (en) 2008-05-06 2009-05-06 Hemangio colony forming cells and non-engrafting hemangio cells
CN2009801258605A CN102083963A (zh) 2008-05-06 2009-05-06 血管瘤集落形成细胞和非移植血管瘤细胞
KR1020167023332A KR101923290B1 (ko) 2008-05-06 2009-05-06 혈관 콜로니 형성 세포 및 비-생착성 혈관 세포
EP18182514.2A EP3441462A1 (fr) 2008-05-06 2009-05-06 Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables
BRPI0912201A BRPI0912201A2 (pt) 2008-05-06 2009-05-06 células formadoras de colônias de hemangios e células de hemangio não enxertantes
KR1020187033531A KR20180127528A (ko) 2008-05-06 2009-05-06 혈관 콜로니 형성 세포 및 비-생착성 혈관 세포
CA2722693A CA2722693C (fr) 2008-05-06 2009-05-06 Cellules formant des colonies hemangioblastiques et cellules hemangioblastiques non transplantables
US15/203,639 US20170152481A1 (en) 2008-05-06 2016-07-06 Hemangio colony forming cells and non-engrafting hemangio cells
US16/690,888 US20200157503A1 (en) 2008-05-06 2019-11-21 Hemangio colony forming cells and non-engrafting hemangio cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12680208P 2008-05-06 2008-05-06
US61/126,802 2008-05-06
US19028208P 2008-08-26 2008-08-26
US61/190,282 2008-08-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/991,096 A-371-Of-International US9410123B2 (en) 2008-05-06 2009-05-06 Hemangio colony forming cells and non-engrafting hemangio cells
US15/203,639 Division US20170152481A1 (en) 2008-05-06 2016-07-06 Hemangio colony forming cells and non-engrafting hemangio cells

Publications (2)

Publication Number Publication Date
WO2009137624A2 WO2009137624A2 (fr) 2009-11-12
WO2009137624A3 true WO2009137624A3 (fr) 2010-01-07

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Application Number Title Priority Date Filing Date
PCT/US2009/043043 WO2009137624A2 (fr) 2008-05-06 2009-05-06 Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables

Country Status (12)

Country Link
US (3) US9410123B2 (fr)
EP (3) EP2712921B1 (fr)
JP (5) JP2011519576A (fr)
KR (3) KR101923290B1 (fr)
CN (2) CN102083963A (fr)
AU (1) AU2009244231B2 (fr)
BR (1) BRPI0912201A2 (fr)
CA (2) CA2722693C (fr)
ES (1) ES2685969T3 (fr)
MX (1) MX2010012088A (fr)
RU (1) RU2010149895A (fr)
WO (1) WO2009137624A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102660495A (zh) 2006-04-14 2012-09-12 先进细胞技术公司 血管瘤集落形成细胞
EP2712921B1 (fr) 2008-05-06 2018-07-11 Astellas Institute for Regenerative Medicine Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables
CN102083960B (zh) * 2008-05-06 2014-12-03 先进细胞技术公司 用于制备衍生自多能干细胞的去核类红细胞的方法
EP2475767B1 (fr) * 2009-09-08 2017-04-19 Kyoto University Méthode de production de mastocytes à partir de cellules souches pluripotentes
KR20210066020A (ko) 2009-12-04 2021-06-04 아스텔라스 인스티튜트 포 리제너러티브 메디슨 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
CA2781969A1 (fr) 2009-12-04 2011-06-09 Stem Cell & Regenerative Medicine International, Inc. Procede de generation de cellules tueuses naturelles et de cellules dendritiques a partir d'hemangioblastes derives de cellules souches humaines
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9835644B2 (en) * 2011-08-18 2017-12-05 Koninklijke Philips N.V. Estimating velocity in a horizontal or vertical direction from acceleration measurements
JP6584956B2 (ja) 2012-12-21 2019-10-02 アステラス インスティテュート フォー リジェネレイティブ メディシン 多能性幹細胞から血小板を生産するための方法およびその組成物
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
KR102651291B1 (ko) 2015-08-18 2024-03-26 아스텔라스 인스티튜트 포 리제너러티브 메디슨 임상 제제
EP3365433A1 (fr) 2015-10-20 2018-08-29 FUJIFILM Cellular Dynamics, Inc. Procédés de différenciation dirigée de cellules souches pluripotentes en cellules immunes
US10906976B2 (en) * 2015-12-01 2021-02-02 The Chinese University Of Hong Kong Induction of immunotolerance to improve acceptance of tissue derived from pluripotent stem cells
MX2019003689A (es) * 2016-10-05 2019-08-22 Fujifilm Cellular Dynamics Inc Metodos para diferenciacion dirigida de citoblastos pluripotentes a células inminitarias homocigotas de antígenos leucocitarios humanos.
WO2018231951A1 (fr) * 2017-06-13 2018-12-20 Fate Therapeutics, Inc. Compositions et procédés permettant d'induire des cellules myéloïdes suppressives et leur utilisation
EP4022038A1 (fr) 2019-08-28 2022-07-06 Astellas Institute for Regenerative Medicine Compositions et méthodes de traitement de maladies vasculaires
CA3151637A1 (fr) 2019-08-28 2021-03-04 Astellas Institute For Regenerative Medicine Procedes de traitement de maladies vasculaires
TW202237826A (zh) 2020-11-30 2022-10-01 瑞士商克里斯珀醫療股份公司 基因編輯的自然殺手細胞
CN112159790B (zh) * 2020-12-03 2021-03-09 至仁生命科技(天津)有限公司 从围产期组织中纯化多能血管祖细胞的方法
WO2022144632A1 (fr) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions et procédés de différenciation de cellules souches en cellules nk
WO2023230462A2 (fr) * 2022-05-23 2023-11-30 The Trustees Of The University Of Pennsylvania Appareil, système et procédé de formation d'un modèle de moelle osseuse perturbable dans un système microphysiologique tridimensionnel
WO2024019962A1 (fr) 2022-07-18 2024-01-25 Astellas Institute For Regenerative Medicine Procédés de traitement d'une lésion cérébrale

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080014180A1 (en) * 2006-04-14 2008-01-17 Robert Lanza Hemangio-colony forming cells

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5128259A (en) 1989-10-27 1992-07-07 Hahnemann University Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation
EP1179350A3 (fr) 1993-08-12 2003-01-02 Cytotherapeutics, Inc. Système cellulaire encapsulé pour implantation dans le SNC hunain
US5599705A (en) 1993-11-16 1997-02-04 Cameron; Robert B. In vitro method for producing differentiated universally compatible mature human blood cells
WO1995017500A1 (fr) 1993-12-23 1995-06-29 Abs Global, Inc. Cellules souches d'embryons utilisees comme donneuses de noyaux et procedes de transfert de noyaux pour la production d'animaux chimeriques et transgeniques
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5914268A (en) 1994-11-21 1999-06-22 National Jewish Center For Immunology & Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US6063593A (en) 1996-11-12 2000-05-16 University Of Southern California University Park Campus TGFβ1 responsive bone marrow derived cells to express a recombinant protein
WO1999067360A2 (fr) 1998-06-25 1999-12-29 Hemosol Inc. Culture efficace de cellules souches permettant la production d'hemoglobine
BR0014864A (pt) 1999-10-15 2002-11-19 Advanced Cell Tech Inc Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem
JP2003533976A (ja) 2000-01-07 2003-11-18 オレゴン ヘルス アンド サイエンス ユニバーシティ 胚分割による霊長類子孫のクローン性増殖
US7795026B2 (en) 2000-01-21 2010-09-14 The Johns Hopkins University School Of Medicine Methods for obtaining human embryoid body-derived cells
US6602711B1 (en) 2000-02-21 2003-08-05 Wisconsin Alumni Research Foundation Method of making embryoid bodies from primate embryonic stem cells
AU8617301A (en) 2000-08-01 2002-02-13 Yissum Res Dev Co Directed differentiation of embryonic cells
WO2002078449A2 (fr) 2001-04-02 2002-10-10 Advanced Cell Technology, Inc. Procede permettant de faciliter la production de types de cellules et de tissus differencies a partir de cellules pluripotentes et multipotentes embryonnaires et adultes
EP1393066A4 (fr) 2001-05-15 2006-01-25 Rappaport Family Inst For Res Cellules produisant de l'insuline derivees de cellules souches embryonnaires humaines
TW487144U (en) * 2001-08-14 2002-05-11 Shin-Yan Lin Structure improvement for blowing machine
US20030232430A1 (en) 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
JP5364224B2 (ja) 2001-12-07 2013-12-11 ジェロン・コーポレーション ヒト胚性幹細胞に由来する造血細胞
US20030217374A1 (en) 2002-01-15 2003-11-20 Advanced Cell Technology Cloning B and T lymphocytes
US20040091936A1 (en) 2002-05-24 2004-05-13 Michael West Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank
US20040052771A1 (en) 2002-07-12 2004-03-18 Lim Sai Kiang Hemangioblast progenitor cells
WO2004029200A2 (fr) 2002-09-26 2004-04-08 Children's Medical Center Corporation Procede d'augmentation de la proliferation et/ou de la differentiation hematopoietique de cellules souches
WO2004029231A1 (fr) 2002-09-26 2004-04-08 Institut National De La Sante Et De La Recherche Medicale Compositions et procedes d'amplification de cellules souches humaines
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
AU2004291559B2 (en) 2003-11-19 2008-10-16 Australian Stem Cell Centre Limited Methods for producing blood products from pluripotent cells in cell culture
AU2005212432A1 (en) 2004-02-09 2005-08-25 Indiana University Research And Technology Corporation Isolation, expansion and use of clonogenic endothelial progenitor cells
WO2005097979A2 (fr) 2004-03-31 2005-10-20 Newlink Genetics Corporation Procedes et compositions destines a l'obtention de cellules souches hematopoietiques derivees de cellules souches embryonnaires et utilisations
WO2005118780A1 (fr) 2004-06-04 2005-12-15 Universite Pierre Et Marie Curie - Paris Vi Methode de production de globules rouges
CA2586053C (fr) 2004-11-01 2013-07-30 Wisconsin Alumni Research Foundation Plaquettes de cellules souches
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
EP1885845A2 (fr) 2005-06-01 2008-02-13 Wisconsin Alumni Research Foundation Methode d'elaboration de cellules dendritiques a partir de cellules souches embryonnaires
AU2007215276B2 (en) 2006-02-09 2013-09-19 Maryna E. Gumenyuk Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells
CN101045914A (zh) 2006-03-29 2007-10-03 中国人民解放军军事医学科学院野战输血研究所 体外诱导造血干/祖细胞分化为成熟红细胞的方法与应用
US20070298496A1 (en) 2006-06-23 2007-12-27 Hung-Chih Kuo Method of deriving pluripotent stem cells from a single blastomere
US20080108044A1 (en) 2006-11-08 2008-05-08 Deepika Rajesh In vitro differentiation of hematopoietic cells from primate embryonic stem cells
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
WO2008151386A1 (fr) 2007-06-15 2008-12-18 Australian Stem Cell Centre Ltd Différenciation de mégacaryocytes
WO2009104825A1 (fr) 2008-02-18 2009-08-27 Kaist Procédé pour induire la différenciation de cellules souches embryonnaires en hémangioblaste
EP2712921B1 (fr) 2008-05-06 2018-07-11 Astellas Institute for Regenerative Medicine Cellules formant des colonies hémangioblastiques et cellules hémangioblastiques non transplantables
CN102083960B (zh) 2008-05-06 2014-12-03 先进细胞技术公司 用于制备衍生自多能干细胞的去核类红细胞的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080014180A1 (en) * 2006-04-14 2008-01-17 Robert Lanza Hemangio-colony forming cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TAKAHASHI ET AL.: "Induction of pluripotent stem cells from adult human fibroblasts by defined factors.", CELL, vol. 131, no. 5, 30 November 2007 (2007-11-30), pages 861 - 72, XP002555952 *
VERFAILLIE ET AL.: "Kinetics of engraftment of CD34(-) and CD34(+) cells from mobilized blood differs from that of CD34(-) and CD34(+) cells from bone marrow.", EXPER HEMATOL, vol. 28, no. 9, September 2000 (2000-09-01), pages 1071 - 1079, XP008145475 *

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US20110064705A1 (en) 2011-03-17
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JP2020114233A (ja) 2020-07-30
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BRPI0912201A2 (pt) 2019-09-24
RU2010149895A (ru) 2012-06-20
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