MX2012000455A - Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas. - Google Patents

Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas.

Info

Publication number
MX2012000455A
MX2012000455A MX2012000455A MX2012000455A MX2012000455A MX 2012000455 A MX2012000455 A MX 2012000455A MX 2012000455 A MX2012000455 A MX 2012000455A MX 2012000455 A MX2012000455 A MX 2012000455A MX 2012000455 A MX2012000455 A MX 2012000455A
Authority
MX
Mexico
Prior art keywords
hypoxic conditions
under hypoxic
extracellular matrix
conditioned medium
cells cultured
Prior art date
Application number
MX2012000455A
Other languages
English (en)
Inventor
Gail K Naughton
Frank Ziegler
Mark Baumgartner
Kyle Nickey
Original Assignee
Histogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/501,312 external-priority patent/US20100166824A1/en
Priority claimed from US12/509,171 external-priority patent/US8530415B2/en
Priority claimed from US12/547,422 external-priority patent/US8524494B2/en
Priority claimed from US12/632,721 external-priority patent/US8535913B2/en
Application filed by Histogen Inc filed Critical Histogen Inc
Publication of MX2012000455A publication Critical patent/MX2012000455A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/02—Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Sustainable Development (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Divulgado es un método para producir composiciones incluyendo proteína embriónicas. El método incluye cultivar células bajo condiciones hipóxicas sobre un soporte biocompatible in vitro. El método de cultivo produce fracciones tanto soluble y no soluble, las cuales pueden usarse por separado o en combinación para obtener composiciones fisiológicamente aceptables útiles en una variedad de aplicaciones.
MX2012000455A 2009-07-10 2010-07-09 Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas. MX2012000455A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/501,312 US20100166824A1 (en) 2008-01-30 2009-07-10 Extracellular matrix compositions
US12/509,171 US8530415B2 (en) 2008-01-30 2009-07-24 Repair and/or regeneration of cells with a composition produced by culturing fibroblast cells under hypoxic conditions
US12/547,422 US8524494B2 (en) 2008-01-30 2009-08-25 Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
US12/632,721 US8535913B2 (en) 2008-01-30 2009-12-07 Soluble composition for promoting hair growth produced by hypoxic culture of fibroblasts cells
PCT/US2010/041583 WO2011006107A1 (en) 2009-07-10 2010-07-09 Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions

Publications (1)

Publication Number Publication Date
MX2012000455A true MX2012000455A (es) 2012-04-11

Family

ID=43429571

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000455A MX2012000455A (es) 2009-07-10 2010-07-09 Composiciones de matriz extra-celular y medio acondicionado a partir de celulas cultivadas bajo condiciones hipoxicas.

Country Status (16)

Country Link
EP (1) EP2451964B1 (es)
KR (1) KR101834019B1 (es)
CN (1) CN102482698B (es)
AU (1) AU2010271212B2 (es)
BR (1) BR112012000517B1 (es)
CA (2) CA3152419A1 (es)
DK (1) DK2451964T3 (es)
ES (1) ES2667265T3 (es)
HR (1) HRP20180594T1 (es)
HU (1) HUE038882T2 (es)
MX (1) MX2012000455A (es)
NO (1) NO2451964T3 (es)
PL (1) PL2451964T3 (es)
PT (1) PT2451964T (es)
RU (1) RU2631488C2 (es)
WO (1) WO2011006107A1 (es)

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US10533191B2 (en) 2014-01-15 2020-01-14 Serucell Corporation Therapeutic serum obtained from co-cultured cells
CN109963939A (zh) * 2016-04-26 2019-07-02 伊斯雷顿公司 多能细胞的衍生和自我更新及其用途
FR3055806B1 (fr) * 2016-09-15 2024-04-12 Symbioken Procede de preparation d’une composition pour la reparation tissulaire
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CN106511384A (zh) * 2016-11-08 2017-03-22 广州医科大学附属第三医院 一种用于促进糖尿病创面愈合的冻干粉及其制备方法
JP6557717B2 (ja) 2016-12-23 2019-08-07 インスコビー・インコーポレイテッドＩｎｓｃｏｂｅｅ，Ｉｎｃ． 生体植立用インプラント及びその製造方法
KR102009081B1 (ko) * 2016-12-23 2019-08-09 주식회사 인스코비 발모 촉진을 위한 생체 식립용 임플란트
US20200390678A1 (en) 2017-11-16 2020-12-17 Aivita Biomedical, Inc. Use of cell membrane-bound signaling factors
WO2019140267A1 (en) * 2018-01-12 2019-07-18 Histogen, Inc. Nutraceutical products from cell conditioned medium from cells cultured under hypoxic conditions
WO2019152522A1 (en) 2018-01-30 2019-08-08 Histogen, Inc. Extracellular vesicles derived from cells cultured under hypoxic conditions and uses thereof
KR102454189B1 (ko) * 2018-05-04 2022-10-14 연세대학교 산학협력단 저산소 조건을 이용한 모유두 세포 및 세포 스페로이드의 제조방법
US20210299036A1 (en) * 2018-08-02 2021-09-30 Histogen, Inc. Conditioned medium and extracellular matrix compositions and uses thereof
KR20200040536A (ko) * 2018-10-10 2020-04-20 사회복지법인 삼성생명공익재단 저산소 조건에서 섬유아세포를 배양하여 제조한 조정배지를 포함하는 암세포 사멸 유도용 조성물 및 이의 제조 방법
KR102135178B1 (ko) 2019-01-15 2020-07-17 한남대학교 산학협력단 고중력에 노출된 쥐의 유전자 분석방법
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KR102166453B1 (ko) 2020-02-03 2020-10-15 중앙대학교 산학협력단 Hapln1을 포함하는 폐질환 예방 또는 치료용 조성물
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Also Published As

Publication number Publication date
KR101834019B1 (ko) 2018-03-02
HRP20180594T1 (hr) 2018-08-10
AU2010271212B2 (en) 2015-07-16
AU2010271212A1 (en) 2012-03-01
BR112012000517A2 (pt) 2021-01-05
EP2451964A1 (en) 2012-05-16
PT2451964T (pt) 2018-05-07
KR20120089235A (ko) 2012-08-09
CA3152419A1 (en) 2011-01-13
RU2631488C2 (ru) 2017-09-22
NO2451964T3 (es) 2018-06-23
BR112012000517B1 (pt) 2022-04-12
WO2011006107A1 (en) 2011-01-13
ES2667265T3 (es) 2018-05-10
EP2451964B1 (en) 2018-01-24
RU2012104650A (ru) 2013-08-20
PL2451964T3 (pl) 2018-08-31
DK2451964T3 (en) 2018-04-30
CN102482698B (zh) 2018-09-25
HUE038882T2 (hu) 2018-12-28
CA2767600C (en) 2022-05-31
CA2767600A1 (en) 2011-01-13
EP2451964A4 (en) 2013-04-17
CN102482698A (zh) 2012-05-30

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