WO2009104932A3 - 복합제제 - Google Patents

복합제제 Download PDF

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Publication number
WO2009104932A3
WO2009104932A3 PCT/KR2009/000832 KR2009000832W WO2009104932A3 WO 2009104932 A3 WO2009104932 A3 WO 2009104932A3 KR 2009000832 W KR2009000832 W KR 2009000832W WO 2009104932 A3 WO2009104932 A3 WO 2009104932A3
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WO
WIPO (PCT)
Prior art keywords
composite preparation
aspirin
present
clopidogrel
pharmaceutically acceptable
Prior art date
Application number
PCT/KR2009/000832
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English (en)
French (fr)
Other versions
WO2009104932A2 (ko
Inventor
김성욱
전성수
조영관
구자성
선상욱
배정원
Original Assignee
한올제약주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한올제약주식회사 filed Critical 한올제약주식회사
Priority to CN2009801060399A priority Critical patent/CN101951896B/zh
Priority to US12/919,000 priority patent/US20110038931A1/en
Priority to JP2010547567A priority patent/JP2011512406A/ja
Priority to EP09713514A priority patent/EP2255797A4/en
Publication of WO2009104932A2 publication Critical patent/WO2009104932A2/ko
Publication of WO2009104932A3 publication Critical patent/WO2009104932A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 약리학적 활성성분으로 아스피린, 또는 그의 약제학적으로 허용가능한 염을 포함하는 선방출성 구획, 및 약리학적 활성성분으로 클로피도그렐, 그의 이성질체 또는 그의 약제학적으로 허용가능한 염을 포함하는 지연방출성 구획을 포함하는 복합제제를 제공한다. 본 발명의 복합제제는 각각의 단일제 치료, 또는 동시복용 치료시보다 훨씬 우수한 항혈소판 응집효과를 나타내며, 1일 1회 투여제형으로서 환자의 복약 순응도를 향상시킬 수 있을 뿐만 아니라 아스피린의 장기투여에 따른 부작용을 감소시킬 수 있다. 또한 본 발명의 복합제제는 아스피린의 복용량 감소에도 불구하고 우수한 혈소판 응집 억제효과를 나타내며, 클로피도그렐의 내성을 감수성으로 전환시켜 주어 클로피도그렐 내성으로 인한 중대한 부작용을 방지해 주며, 일반적인 보관조건에서 안정하여 장기간 보관이 가능한 장점이 있다.
PCT/KR2009/000832 2008-02-22 2009-02-21 복합제제 WO2009104932A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2009801060399A CN101951896B (zh) 2008-02-22 2009-02-21 复合制剂
US12/919,000 US20110038931A1 (en) 2008-02-22 2009-02-21 Composite preparation
JP2010547567A JP2011512406A (ja) 2008-02-22 2009-02-21 複合製剤
EP09713514A EP2255797A4 (en) 2008-02-22 2009-02-21 COMPOSITE PREPARATION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0016115 2008-02-22
KR20080016115 2008-02-22

Publications (2)

Publication Number Publication Date
WO2009104932A2 WO2009104932A2 (ko) 2009-08-27
WO2009104932A3 true WO2009104932A3 (ko) 2009-11-05

Family

ID=40986068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/000832 WO2009104932A2 (ko) 2008-02-22 2009-02-21 복합제제

Country Status (6)

Country Link
US (1) US20110038931A1 (ko)
EP (1) EP2255797A4 (ko)
JP (1) JP2011512406A (ko)
KR (1) KR100949273B1 (ko)
CN (1) CN101951896B (ko)
WO (1) WO2009104932A2 (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101695496A (zh) * 2009-10-15 2010-04-21 苏春华 一种含有三氟柳和氯吡格雷的药物组合物
KR101320802B1 (ko) * 2010-02-16 2013-10-23 주식회사 드림파마 방출 제어형 사포그릴레이트 염산염 함유 다층 정제
JP5932487B2 (ja) * 2011-05-31 2016-06-08 沢井製薬株式会社 クロピドグレル含有錠剤及びその製造方法
BR112014006124A2 (pt) * 2011-09-14 2017-04-11 Pozen Inc dosagem faseada de clopidogrel
KR101675501B1 (ko) 2011-11-02 2016-11-14 한국유나이티드제약 주식회사 클로피도그렐 및 아스피린의 복합제제
AU2012349771A1 (en) * 2011-12-09 2014-07-03 Wockhardt Limited Methods for treating cardiovascular disorder
KR101473268B1 (ko) * 2012-03-09 2014-12-16 주식회사유한양행 클로피도그렐과 아스피린을 포함하는 약학 조성물 및 그의 제조방법
KR101378973B1 (ko) * 2012-04-13 2014-03-28 한미약품 주식회사 구형에 가까운 형태의 다중 투여 단위 정제를 포함하는 경질 캡슐 복합 제형 및 이의 제조방법
CN102657631B (zh) * 2012-06-03 2013-06-05 杭州朱养心药业有限公司 硫酸氢氯吡格雷片剂及其制备方法
JP2013253030A (ja) * 2012-06-06 2013-12-19 Japan Vam & Poval Co Ltd フィルムコーティング組成物並びに経口固形製剤及びその製造方法
KR101502588B1 (ko) * 2013-05-01 2015-03-16 한국유나이티드제약 주식회사 클로피도그렐 및 아스피린의 복합제제
CN104523627B (zh) * 2014-12-18 2017-04-12 成都苑东生物制药股份有限公司 一种硫酸氢氯吡格雷片药物组合物及其制备方法
KR101764785B1 (ko) * 2015-05-29 2017-08-07 한국유나이티드제약 주식회사 약제학적 복합제제
CN109069436A (zh) * 2016-03-16 2018-12-21 韩国联合制药株式会社 含有氯吡格雷和阿司匹林的复合制剂
CN107093351A (zh) * 2017-05-24 2017-08-25 聊城职业技术学院 一种仿真注射用青霉素钠制剂及其应用
AU2017432640B2 (en) 2017-09-22 2023-11-30 Vectura Inc. Dry powder compositions with magnesium stearate
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
CN109180701A (zh) * 2018-09-07 2019-01-11 中国药科大学 一种化合物2016a0c1药物组合物的共无定形物
UY39094A (es) * 2020-02-27 2021-07-30 Hk Inno N Corp Composición farmacéutica que comprende compuesto derivado de bencimidazol
CN112587495A (zh) * 2020-12-14 2021-04-02 乐普药业股份有限公司 一种阿司匹林和硫酸氢氯吡格雷复方制剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010022508A (ko) * 1997-07-31 2001-03-15 추후보정 3-히드록시-3-메틸글루타릴 조효소 ａ 환원 효소 억제제와니코틴산 화합물의 조성물 및 야간에 1일 1회 투여하여고지질혈증을 치료하는 방법
KR20040079980A (ko) * 2002-02-01 2004-09-16 데포메드 인코퍼레이티드 속방성 및 서방성 약물 모두를 송달하는 경구 투약 형태의제조방법
KR20070078625A (ko) * 2006-01-27 2007-08-01 씨제이 주식회사 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법
KR20070098823A (ko) * 2004-11-24 2007-10-05 플라멜 테크놀로지스 복합 마이크로캡슐 형태의, 적어도 하나의 활성 성분의조절된 방출을 위한 경구용 약제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
IT1276689B1 (it) * 1995-06-09 1997-11-03 Applied Pharma Res Forma farmaceutica solida ad uso orale
FR2744918B1 (fr) * 1996-02-19 1998-05-07 Sanofi Sa Nouvelles associations de principes actifs contenant un derive de thieno(3,2-c)pyridine et un antithrombotique
NZ520176A (en) * 1997-07-31 2005-02-25 Kos Life Sciences Inc Combinations of HMG-CoA reductase inhibitors and nicotinic acid compounds and methods for treating hyperlipidemia once a day at night
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
FR2792836B3 (fr) * 1999-04-30 2001-07-27 Sanofi Sa Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel
KR100504013B1 (ko) * 2003-02-28 2005-07-28 한국유나이티드제약 주식회사 제어방출형 경구 펠렛제제 및 그 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010022508A (ko) * 1997-07-31 2001-03-15 추후보정 3-히드록시-3-메틸글루타릴 조효소 ａ 환원 효소 억제제와니코틴산 화합물의 조성물 및 야간에 1일 1회 투여하여고지질혈증을 치료하는 방법
KR20040079980A (ko) * 2002-02-01 2004-09-16 데포메드 인코퍼레이티드 속방성 및 서방성 약물 모두를 송달하는 경구 투약 형태의제조방법
KR20070098823A (ko) * 2004-11-24 2007-10-05 플라멜 테크놀로지스 복합 마이크로캡슐 형태의, 적어도 하나의 활성 성분의조절된 방출을 위한 경구용 약제
KR20070078625A (ko) * 2006-01-27 2007-08-01 씨제이 주식회사 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법

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EP2255797A2 (en) 2010-12-01
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WO2009104932A2 (ko) 2009-08-27
EP2255797A4 (en) 2011-09-07
JP2011512406A (ja) 2011-04-21
CN101951896B (zh) 2012-11-28
KR100949273B1 (ko) 2010-03-25
KR20090091076A (ko) 2009-08-26

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