WO2009096855A1 - Blood clot removal device, system, and method - Google Patents

Blood clot removal device, system, and method Download PDF

Info

Publication number
WO2009096855A1
WO2009096855A1 PCT/SE2009/000040 SE2009000040W WO2009096855A1 WO 2009096855 A1 WO2009096855 A1 WO 2009096855A1 SE 2009000040 W SE2009000040 W SE 2009000040W WO 2009096855 A1 WO2009096855 A1 WO 2009096855A1
Authority
WO
WIPO (PCT)
Prior art keywords
patient
energy
clot removal
blood
removal device
Prior art date
Application number
PCT/SE2009/000040
Other languages
French (fr)
Inventor
Peter Forsell
Original Assignee
Milux Holding Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Milux Holding Sa filed Critical Milux Holding Sa
Priority to EP21199129.4A priority Critical patent/EP3964243A1/en
Priority to US12/864,828 priority patent/US10729894B2/en
Priority to EP09706196.4A priority patent/EP2244662B1/en
Priority to ES09706196T priority patent/ES2901553T3/en
Publication of WO2009096855A1 publication Critical patent/WO2009096855A1/en
Priority to US16/984,368 priority patent/US11839848B2/en
Priority to US18/499,253 priority patent/US20240058736A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/66—Regeneration of the filtering material or filter elements inside the filter
    • B01D46/68—Regeneration of the filtering material or filter elements inside the filter by means acting on the cake side involving movement with regard to the filter elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0004—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse
    • A61F2/0031—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra
    • A61F2/0036—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra implantable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/72—Cassettes forming partially or totally the fluid circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/79—Filters for solid matter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/80—Suction pumps
    • A61M1/82—Membrane pumps, e.g. bulbs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/857—Implantable blood tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/871—Energy supply devices; Converters therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/66—Regeneration of the filtering material or filter elements inside the filter
    • B01D46/68—Regeneration of the filtering material or filter elements inside the filter by means acting on the cake side involving movement with regard to the filter elements
    • B01D46/681—Regeneration of the filtering material or filter elements inside the filter by means acting on the cake side involving movement with regard to the filter elements by scrapers, brushes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/48—Operating or control means, e.g. from outside the body, control of sphincters
    • A61F2/482—Electrical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/48—Operating or control means, e.g. from outside the body, control of sphincters
    • A61F2/484—Fluid means, i.e. hydraulic or pneumatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0001—Means for transferring electromagnetic energy to implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0001—Means for transferring electromagnetic energy to implants
    • A61F2250/0002—Means for transferring electromagnetic energy to implants for data transfer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M2027/004—Implant devices for drainage of body fluids from one part of the body to another with at least a part of the circuit outside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7554—General characteristics of the apparatus with filters with means for unclogging or regenerating filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1021—Abdominal cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1078—Urinary tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/66—Regeneration of the filtering material or filter elements inside the filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/66—Regeneration of the filtering material or filter elements inside the filter
    • B01D46/79—Regeneration of the filtering material or filter elements inside the filter by liquid process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/66—Regeneration of the filtering material or filter elements inside the filter
    • B01D46/86—Cleaning the filter surface by interrupting suction so that the filter cake falls by gravity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/88—Replacing filter elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/90—Devices for taking out of action one or more units of multi-unit filters, e.g. for regeneration or maintenance

Definitions

  • the present invention relates generally to a device and a system implantable in a blood flow passageway of a human or mammal patient for removing blood clots, and more particularly to a system for removing blood clots in a vascular system of the patient, one example being a heart pump system.
  • the invention also relates to a method of removing blood clots.
  • BACKGROUND Today many implants are provided where the blood comes into contact with foreign material. All such implants have an associated risk of triggering blood clots. Such clots may become loose and may create severe damages at other parts of the body. Blood clots reaching the brain are the most dangerous ones and implants in the heart region may therefore be a first priority (although not limited to) of a blood clot removal system.
  • One example of such implants and one example of use for the blood clot removal system may be heart help pumps. When a person has heart failure, his or her heart can't pump enough blood to meet the body's needs. In some cases, an advanced treatment such as a heart pump may be recommended.
  • a heart pump takes over the function of one or both of the heart's lower chambers, with the potential to improve your symptoms and quality of life. Once considered a last resort for prolonging life until a donated heart became available, heart pumps have become a possible long-term treatment for selected people with heart failure.
  • a heart pump either takes over or assists the pumping role of the left ventricle - the heart's main pumping chamber.
  • Part of the device, such as an electronic pump is implanted in the heart and abdomen, and part, such as an electronic control unit, remains outside your body.
  • An energy supply, such as a battery, can be provided either outside the body or be implanted.
  • One tube carries blood from the left ventricle of the heart and into the pump. Another tube takes blood pumped from the device into the artery to be circulated throughout the body.
  • a heart pump can be a lifesaving treatment.
  • the potential risks are serious, including the risk of having blood clots in the arteries leading from the heart.
  • An object of the present invention is to provide a device, a system, and a method for removing blood clots in the vascular system of a patient.
  • the invention is based on the realization that a blood clot removal device can be implanted in a patient instead of being external of the patient.
  • a blood clot removal device for removing blood clots from the vascular system of a patient, the blood clot removal device being implantable in the patient's body and comprising a blood flow passageway, a filter provided in the blood flow passageway for filtering blood clots, and a cleaning device for cleaning the filter.
  • a blood flow passageway for filtering blood clots
  • a cleaning device for cleaning the filter.
  • One possibility is to clean the filter mechanically.
  • the cleaning device preferably is adapted to move blood clots away from the blood flow passageway to a place free inside the patient's body, where the body itself will take care of the blood clots.
  • a collecting volume such as a bag, is provided for collecting cleaned blood that has been mechanically cleaned from the filter. Most likely such a bag will then be placed inside the body.
  • the cleaning device is adapted to slice, push or scratch away any clots from the filter, but the cleaning device can also suck away any clots from the filter.
  • the cleaning device comprises a first piston, with preferably is provided with a first recess in an outer end portion thereof to collect blood clots removed from the filter.
  • the first piston By providing the first piston with a plurality of channels for accommodating the filter in an extended position of the first piston, it can surround the filter, ensuring essentially complete removal of blood clots therefrom. This is preferably effected if the first piston is movable in a direction perpendicular to the direction of the blood flow passageway.
  • the movement of the first piston can be controlled by a source of pressurized air, ensuring rapid acceleration of the first piston and thereby short cleaning cycles.
  • the movement of the first piston can alternatively be controlled by an electric motor, a solenoid or the like.
  • the filter is of biocompatible material in order to avoid unnecessary interference with the blood environment.
  • the blood clot removal device is used in a system comprising a heart pump connected to the blood flow passageway, wherein a first tube preferably connects the heart pump to the left ventricle of the patient's heart and a second tube connects the heart pump connected to the patient's aorta.
  • the filter preferably comprises a plurality of strips, which may be equally spaced to form a filter for blood clots.
  • the distance between two adjacent strips is preferably less than 2 millimeters, and even more preferably less than 1.0 millimeter. The distance depends on which size blood clots you want to avoid.
  • a second piston is provided across the blood flow passageway from the first piston, wherein the second piston is movable in a direction essentially perpendicular to the direction of the blood flow passageway and spring biased in the direction of the first piston. If an outer end portion of the second piston is provided with a second recess, the first piston and the second piston cooperate to catch blood clots for further removal. This further removal can be accomplished by means of a third piston, which is movable in a direction perpendicular to both the direction of the blood flow passageway and the direction of movement of the first piston and of the second piston.
  • the blood flow passageway of the blood clot removal device has an essentially square cross-sectional shape, which provides for a laminated flow of the blood, particularly if the square shape is combined with a filter comprising parallel strips.
  • the blood clot removal device is in a preferred embodiment insertable in a blood vessel of the patient, preferably via surgery.
  • the blood clot removal device can be adapted to be placed in the patient's abdomen or thorax.
  • the blood clot removal device is preferably comprised in a system for removing blood clots of a patient.
  • This system can comprise a switch, preferably a subcutaneous switch being adapted to manually and non-invasively control any function of the blood clot removal device.
  • the system for removing blood clots preferably comprises a hydraulic device having a hydraulic reservoir, wherein the blood clot removal device is adapted to non- invasively be regulated by manually pressing the hydraulic reservoir.
  • a wireless remote control can non-invasively regulate any function of the blood clot removal device. Even more important any function of the device may be programmable by such a remote control.
  • a wireless energy transmitter can non-invasively energize the blood clot removal device.
  • An energy source is preferably adapted to power the blood clot removal device.
  • the energy source can comprise an internal energy source, such as an internal energy source adapted to receive energy from an external energy source transmitting energy in a wireless mode. The internal energy source can then be charged from the energy in the wireless mode.
  • the system preferably comprises a feedback device for sending information from inside the patient's body to the outside thereof to give feedback information related to at least one functional parameter of the device or a physical parameter of the patient, thereby optimizing the performance of the system.
  • One preferred functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
  • the system preferably comprises an operation device for operating the blood clot removal device.
  • This operation device can comprise a motor or a pump, an electrically powered operation device, a hydraulic operation device, or an electric motor.
  • a physical parameter sensor such as a pressure sensor
  • An internal control unit can act in response to the physical parameter sensed by the sensor.
  • a functional parameter sensor sensing a functional parameter of the blood clot removal device can also be provided.
  • An internal control unit acting in response to the functional parameter sensed by the sensor can also be provided.
  • a method of using the system for removing blood clots is also provided, wherein at least one function of the blood clot removal device is regulated from outside the patient's body.
  • the regulation is in a preferred embodiment non-invasively by manually pressing a subcutaneous switch.
  • non- invasively regulation are performed by manually pressing a hydraulic reservoir connected to the blood clot removal device.
  • the system for removing blood clots comprises a wireless remote " control, wherein non-invasively regulation is performed using said remote control.
  • the system for removing blood clots comprises a wireless energy transmitter, wherein non-invasively regulation is performed using said energy transmitter.
  • an energy source is used for powering and adjusting any function of the blood clot removal device.
  • the energy source may comprise an internal energy source, which preferably is associated with an external energy source adapted to transmit wireless energy. Energy is preferably transmitted from the external energy source to charge the internal energy source. Feedback information is preferably sent from inside the body to the outside thereof to give feed back related to the functional parameters of the device or physical parameters of the patient. The functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
  • wireless energy is transmitted for powering the operation device.
  • the method of using a system for removing blood clots comprises the steps of: implanting an implantable source of energy in the patient, providing an external source of energy, controlling the external source of energy to release wireless energy, charging non-invasively the implantable source of energy with the wireless energy, controlling the implantable source of energy from outside the patient's body, and releasing energy for use in connection with operation of the blood clot removal device.
  • the wireless energy is preferably stored in the implantable source of energy.
  • the method of using a system for removing blood clots comprises the steps of: providing an external source of energy outside the patient's body, and controlling the external source of energy from outside the patient's body to release wireless energy, and using released wireless energy for operating the operation device.
  • the wireless energy is preferably transformed into electrical energy inside the patient's body using an implanted energy-transforming device and using the electrical energy when operating the blood clot removal device.
  • the electrical energy is used directly in connection with operation of the blood clot removal device, as a transforming device transforms the wireless energy into the electrical energy.
  • the external source of energy is controlling from outside the patient's body to release non-magnetic wireless energy, and released non-magnetic wireless energy is used for operating the blood clot removal device.
  • the external source of energy is controlled from outside the patient's body to release electromagnetic wireless energy, and released electromagnetic wireless energy is used for operating the blood clot removal device.
  • a method for placing a blood clot removal device comprising a surgical method via a laparoscopic abdominal approach, comprises the steps of: inserting a needle or tube like instrument into the abdomen of the patient's body, using the needle or tube like instrument to fill the patient's abdomen with gas thereby expanding the patient's abdominal cavity, placing at least two laparoscopic trocars in the patient's body, inserting a camera through one of the trocars into the patient's abdomen, inserting at least one dissecting tool through a trocar and dissecting the intended placement area of the patient, placing at least one blood clot removal device in any part of the vascular system in the abdomen, moving blood clots away from the vascular system post operatively to a different part of the body, and powering the device with a source of energy.
  • the blood clots can be moved either to a place that is free in the abdomen, to a place that is free in the abdomen, or to a place that is encapsulated in a closed bag in the abdomen
  • the blood clot removal device is preferably programmable from outside the patients body. By adding the steps of sensing a physical parameter of the patient or a functional parameter of the device, and sending sensing information to an internal control unit adapted for regulating said blood clot removal device, performance is improved.
  • a method of placing a blood clot removal device comprising a surgical method via a laparoscopic thoraxial approach, comprises the steps of: inserting a needle or tube like instrument into the thorax of the patients body, using the needle or tube like instrument to fill the thorax with gas thereby expanding the thoraxical cavity, placing at least two laparoscopic trocars in the patient's body, inserting a camera through one of the trocars into the thorax, inserting at least one dissecting tool through a trocar and dissecting the intended area of the patient, placing at least one blood clot removal device in any part of the vascular system in the thorax, moving blood clots away from vascular system post operatively to a different part of the body, and powering the device with a source of energy.
  • the blood clots can be moved either to a place that is free in the thorax, to a place that is free in the abdomen, or to a place that is encapsulated in
  • the device is preferably programmed from outside the body of the patient.
  • a method for surgically treating a patient needing a blood clot removal device in the vascular system in the patient's abdomen comprises the steps of: cutting an opening in the patient's abdominal wall, dissecting an area of the vascular system, placing a blood clot removal device inside the vascular system, and suturing said abdominal wall.
  • blood clots are moved away from the vascular system into an encapsulated closed bag in the patient's abdomen by means of the blood clot removal device.
  • blood clots are moved to the free abdomen.
  • a method for surgically treating a patient needing a blood clot removal device in the vascular system in the thorax comprises the steps of: cutting an opening in the thorax wall, dissecting the area of the vascular system, placing a blood clot removal device inside the vascular system, and suturing said thorax wall.
  • a step of moving blood clots away from the vascular system can comprise moving blood clots either to a place that is free in the thorax, to a place that is free in the abdomen, or to a place that is encapsulated in a closed bag in the thorax
  • a method using an system for removing blood clots, for postoperatively and non- invasively regulating the blood clot removal device comprises the steps of: moving any blood clots, which have been accumulated in the vascular system of the patient's body, away from the vascular system, and placing the blood clots outside the vascular system. This can be accomplished by an energy source, preferably repeatedly according to a pre-programmed time-schedule.
  • the steps of moving any blood clots away from the vascular system and placing the blood clots outside the vascular system are preferably repeated and at least partly controlled by an internal control unit getting input from a sensor sensing any physical parameter of the patient or any functional parameter of the device.
  • An operation method for surgically placing a blood clot removal device comprises the steps of: cutting the patient's skin, dissecting a placement area where to place the blood clot removal device inside the vascular system in the abdomen or thorax or retroperitoneal or subcutaneously or any limb of the patient, placing the blood clot removal device in the placement area, removing, postoperatively and non-invasively without penetrating the patent's skin, any blood clots from the vascular system to outside thereof, and using energy from an energy source without any penetration through the patient's skin to power the blood clot removal device.
  • Fig. 1 is an overview of the body of a patient having an implanted heart pump.
  • Fig. 2 is a sectional view of a clot removal device according to the invention.
  • Fig. 3 is a cross sectional view of the clot removal device of Fig. 2 taken along the line III-III before a cleaning operation.
  • Fig. 4 is a sectional view of the clot removal device of Fig. 2 taken along the line IV-IV.
  • Fig. 5 is a sectional view similar to that of Fig. 2 showing blood clots before a clot removal operation.
  • Fig. 6 is a sectional view similar to that of Fig. 2 during a first step of a clot removal operation.
  • Fig. 7 is a sectional view similar to that of Fig. 2 during a second step of a clot removal operation.
  • Fig. 8 is a sectional view similar to that of Fig. 2 during a third step of a clot removal operation.
  • Fig. 9 is a cross sectional view similar to that of Fig. 3 but during a cleaning operation.
  • Fig. 10 is a sectional view of the clot removal device of Fig. 8 taken along the line X-X showing a clot ejection piston before ejection of clots.
  • Fig. 11 is a view similar to that of Fig. 9 but after ejection of clots.
  • Fig. 12 is an overall view of a clot removal system according to the invention.
  • Fig. 13 is a schematic diagram of the system of Fig. 12.
  • Figs. 14-29 show various embodiments based on the system of Fig. 13.
  • Figs. 30a and 30b are views of a filter cassette.
  • Figs. 31a and 3 Ib are views of a filter cassette.
  • Fig.l shows a patient 1 having an implanted heart pump 2.
  • the implanted heart pump 2 is connected to the left ventricle 3a of the patient's heart 3 by means of a first tube 2a.
  • the heart pump 2 is also connected to the aorta, generally designated 4, of the patient 1 by means of a second tube 2b. In this way, during operation the heart pump supplements or replaces the blood pumping operation of the patient's heart 3.
  • a blood clot removal device 10 is shown provided in the second tube 2b of the heart pump 2, i.e., in the tube leading to the aorta 4 of the patient 1. This means that part of the blood flow passageway provided by the second tube 2b is replaced by a blood flow passageway in the blood clot removal device 10.
  • the blood clot removal device 10 is thus an artificial device insertable in an artificial blood vessel of the patient.
  • the function of the clot removal device is to remove any blood clots in the blood transported by the second tube 2b. These blood clots are preferably moved to a place free inside the body of the patient.
  • a collecting volume such as a bag 10a connected to the blood clot removal device 10 for subsequent removal or storage.
  • a preferred storage capacity of the bag 10a can be more than 100 milliliters, for example.
  • the blood clot removal device is an artificial device but could be inserted directly into a blood vessel of the patient or connected between two ends of a blood vessel.
  • the clot removal device is preferably insertable in a blood flow passageway of the patient via surgery and is placed in the patient's abdomen or thorax or cephalic or neck region or retroperitoneal or any limb of the patient.
  • Fig. 2 shows a sectional view wherein the blood clot removal device 10 is provided in the blood flow passageway provided by the second tube 2b.
  • a filter 12 is provided across the blood flow passageway 14 formed in a housing 11 with the function of stopping potential blood clots brought forward in the second tube 2b by the blood flow, indicated by arrows in the figure.
  • the filter 12 comprises a plurality of preferably equally spaced strips 12a of some suitable material, such as biocompatible metal or plastic. These strips 12a are preferably arranged mutual parallel.
  • the distance between two adjacent strips is small enough to stop any blood clots.
  • the distance is preferably less than 2 millimeters, and even more preferably less than 1.0 millimeters, but if the goal is to protect the brain from larger clots only the distance could be larger.
  • the blood flow passageway 14 in the preferred embodiment has an essentially square cross-sectional shape, it will be realized that it can take any suitable shape, such as rectangular or circular.
  • a laminar blood flow is achieved downstream of the filter, which is advantageous in a blood clot preventing perspective.
  • the blood flow configuration can be further enhanced by giving the plurality of strips 12a a desired cross-sectional shape, although the rectangular shape shown in Fig. 4 will be adequate for most purposes.
  • a first piston 16 is provided movable in a direction essentially perpendicular to the direction of the blood flow passageway 14, i.e., essentially perpendicular to the direction of the blood flow.
  • This first piston 16 is driven by some suitable actuator means, such as pressurized air, a solenoid arrangement, an electrical servo motor or the like.
  • a motor could be used to build up a stored power that could be released very fast, one example being a spring.
  • pressurized air acts as the actuator means, since by latching the piston by means of a suitable latching means for the piston, building up the air pressure, and subsequently releasing the piston, very high speed of the piston is achieved, with enables short cleaning times of the filter.
  • the outer end portion of the first piston 16, i.e., the end portion facing the blood flow passageway 14, is essentially flush with the wall of the blood flow passageway in a non-active state of the blood clot removal device 10. Also, the outer end portion is provided with a concave portion or recess 16a (exaggerated in the figures) in order to act as a blood clot capturing means, as will be explained below.
  • the strike range of the first piston 16 is such that it extends all way across the blood flow passageway 14, as will be explained below with reference to Figs. 5-8.
  • a number of channels 16b corresponding to the number of strips 12a is provided in the first piston 16 to accommodate the strips when the first piston is in an extended position.
  • the first piston 16 is also provided with a plurality of through holes 17 in the direction of the blood flow passageway. These through holes will allow blood to flow through the blood flow passageway also during a cleaning operation, as will be explained below with reference to Fig. 9.
  • a second piston 18 is provided across the blood flow passageway 14 from the first piston 16. Also this second piston 18 is movable in a direction essentially perpendicular to the direction of the blood flow passageway 14 and is biased in the direction thereof by means of a spring 18a, for example. Likewise, the outer end portion of the second piston is provided with a recess 18b similar to the recess 16a of the first piston 16.
  • the first and second pistons 16, 18, are sealed to the housing 11 by means of a respective sealing 20, such as an O sealing.
  • FIG. 5 is a view similar to that of Fig. 2. However, this figures shows the blood clot removal device 10 during operation, wherein blood clots, generally designated 22, have assembled on the filter 12.
  • the first piston 16 has moved linearly from the retracted starting position shown Fig. 5 to an extended position, wherein the outer end portion thereof is in contact with the second piston 18. Due to the recess 16a in the outer end of the first piston 16, the blood clots 22 have been assembled in the recess 16a, whereby they have been brought with the first piston 16 during the movement thereof. In the step shown in Fig. 6, the blood clots are confined in the recess 16a between the first and second pistons 16, 18.
  • the second piston 18 By moving the first piston 16 an additional distance from the position shown in Fig. 6, the second piston 18 is pushed against the force of the spring 18a to a fully retracted position, see Fig. 7.
  • the plurality of strips 12a is in this position fully received in a respective channel 16b in the first piston. It is seen that the outer ends of the first and second pistons define an unobstructed cavity in which the blood clots are confined. It is thereby possible to remove these by some suitable means.
  • One such means could be a third piston 24, which is movable in a direction perpendicular to both the direction of the blood flow passageway 14 and the direction of movement of the first and second pistons 16, 18.
  • This third piston scrapes off the blood clots collected by the first piston 16 and moves them to a place outside of the blood clot removal device 10 and the blood flow passageway 14.
  • Fig. 9 shows a side view of the first piston 16 in a fully extended position, i.e., corresponding to the view of Fig. 8. It is here seen that in this position the through holes 17 will be aligned with the blood flow passageway 14, thereby allowing blood to flow therethrough also during cleaning of the filter 12.
  • Fig. 10 shows a cross-sectional view taken along line X-X of Fig. 8. It is here seen that the third piston 24 collects the blood clots 22 during a downward movement, indicated by an arrow in the figure. The clots are ejected from the blood clot removal device 10 when the third piston 24 has reached its lower end position, shown in Fig. 11.
  • pressurized air can be used for ejecting the collected blood clots from the cavity formed by the first piston 16 and the second piston 18.
  • a clot removal system generally designated 28 and comprising a clot removal device as described above will now be described with reference to Figs. 12-25.
  • the system of Fig. 12 comprises a blood clot removal device 10 placed in the abdomen of the patient.
  • An internal energy source in the form of an implanted energy transforming device 30 is adapted to supply energy consuming components of the blood clot removal device 10 with energy via a power supply line 32.
  • An external energy transmission device 34 includes a wireless remote control transmitting a wireless signal, which is received by a signal receiver incorporated in the implanted energy transforming device 30.
  • the implanted energy transforming device 30 transforms energy from the signal into electric energy which is supplied via the power supply line 32.
  • Fig. 12 The system of Fig. 12 is shown in a more generalized block diagram form in Fig. 13, wherein the patient's skin 36, generally shown by a vertical line, separates the interior of the patient to the right of the line from the exterior to the left of the line.
  • Fig. 14 shows an embodiment of the invention identical to that of Fig. 13, except that a reversing device in the form of an electric switch 38 operable by polarized energy also is implanted in the patient for reversing the blood clot removal device 10.
  • the wireless remote control of the external energy transmission device 34 transmits a wireless signal that carries polarized energy and the implanted energy transforming device 30 transforms the wireless polarized energy into a polarized current for operating the electric switch 38.
  • the electric switch 38 reverses the function performed by the blood clot removal device 10.
  • Fig. 15 shows an embodiment of the invention identical to that of Fig. 13, except that an operation device 40 implanted in the patient for regulating the blood clot removal device 10 is provided between the implanted energy transforming device 30 and the blood clot removal device 10.
  • This operation device can be in the form of a motor 40, such as an electric servo motor.
  • the motor 40 is powered with energy from the implanted energy transforming device 30, as the remote control of the external energy transmission device 34 transmits a wireless signal to the receiver of the implanted energy transforming device 30.
  • Fig. 16 shows an embodiment of the invention identical to that of Fig. 13, except that it also comprises an operation device is in the form of an assembly 42 including a motor/pump unit 78 and a fluid reservoir 46 is implanted in the patient.
  • the blood clot removal device 10 is hydraulically operated, i.e. hydraulic fluid is pumped by the motor/pump unit 44 from the fluid reservoir 46 through a conduit 48 to the blood clot removal device 10 to operate the clot removal device, and hydraulic fluid is pumped by the motor/pump unit 44 back from the blood clot removal device 10 to the fluid reservoir 46 to return the clot removal device to a starting position.
  • the implanted energy transforming device 30 transforms wireless energy into a current, for example a polarized current, for powering the motor/pump unit 44 via an electric power supply line 50.
  • the operation device comprises a pneumatic operation device.
  • pressurized air can be used for regulation and the fluid reservoir is replaced by an air chamber and the fluid is replaced by air.
  • Fig. 17 shows an embodiment of the invention comprising the external energy transmission device 34 with its wireless remote control, the blood clot removal device 10, in this case hydraulically operated, and the implanted energy transforming device 30, and further comprising a hydraulic fluid reservoir 52, a motor/pump unit 44 and an reversing device in the form of a hydraulic valve shifting device 54, all implanted in the patient.
  • the motor of the motor/pump unit 44 is an electric motor.
  • the implanted energy transforming device 30 powers the motor/pump unit 44 with energy from the energy carried by the control signal, whereby the motor/pump unit 44 distributes hydraulic fluid between the hydraulic fluid reservoir 52 and the blood clot removal device 10.
  • the remote control of the external energy transmission device 34 controls the hydraulic valve shifting device 54 to shift the hydraulic fluid flow direction between one direction in which the fluid is pumped by the motor/pump unit 44 from the hydraulic fluid reservoir 52 to the blood clot removal device 10 to operate the clot removal device, and another opposite direction in which the fluid is pumped by the motor/pump unit 44 back from the blood clot removal device 10 to the hydraulic fluid reservoir 52 to return the clot removal device to a starting position.
  • Fig. 18 shows an embodiment of the invention identical to that of Fig. 13, except that an internal control unit 56 controlled by the wireless remote control of the external energy transmission device 34, an accumulator 58 and a capacitor 60 also are implanted in the patient.
  • the internal control unit 56 arranges storage of electric energy received from the implanted energy transforming device 30 in the accumulator 58, which supplies energy to the blood clot removal device 10.
  • the internal control unit 56 In response to a control signal from the wireless remote control of the external energy transmission device 34, the internal control unit 56 either releases electric energy from the accumulator 58 and transforms the released energy via power lines 62 and 64, or directly transforms electric energy from the implanted energy transforming device 30 via a power line 66, the capacitor 60, which stabilizes the electric current, a power line 68 and the power line 64, for the operation of the blood clot removal device 10.
  • the internal control unit is preferably programmable from outside the patient's body. In a preferred embodiment, the internal control unit is programmed to regulate the blood clot removal device 10 to remove any blood clots from the vascular system and place the blood clots outside the vascular system repeatedly according to a pre- programmed time-schedule.
  • the capacitor 60 in the embodiment of Fig. 18 may be omitted.
  • the accumulator 58 in this embodiment may be omitted.
  • Fig. 19 shows an embodiment of the invention identical to that of Fig. 13, except that a battery 70 for supplying energy for the operation of the blood clot removal device 10 and an electric switch 72 for switching the operation of the blood clot removal device 10 also are implanted in the patient.
  • the electric switch 72 is operated by the energy supplied by the implanted energy transforming device 30 to switch from an off mode, in which the battery 70 is not in use, to an on mode, in which the battery 70 supplies energy for the operation of the blood clot removal device 10.
  • Fig. 20 shows an embodiment of the invention identical to that of Fig. 19, except that an internal control unit 56 controllable by the wireless remote control of the external energy transmission device 34 also is implanted in the patient.
  • the electric switch 72 is operated by the energy supplied by the implanted energy transforming device 30 to switch from an off mode, in which the wireless remote control is prevented from controlling the internal control unit 56 and the battery is not in use, to a standby mode, in which the remote control is permitted to control the internal control unit 56 to release electric energy from the battery 70 for the operation of the blood clot removal device 10.
  • Fig. 21 shows an embodiment of the invention identical to that of Fig. 20, except that an accumulator 58 is substituted for the battery 70 and the implanted components are interconnected differently.
  • the accumulator 58 stores energy from the implanted energy transforming device 30.
  • the internal control unit 56 controls the electric switch 72 to switch from an off mode, in which the accumulator 58 is not in use, to an on mode, in which the accumulator 58 supplies energy for the operation of the blood clot removal device 10.
  • Fig. 22 shows an embodiment of the invention identical to that of Fig. 21, except that a battery 70 also is implanted in the patient and the implanted components are interconnected differently.
  • the internal control unit 56 controls the accumulator 58 to deliver energy for operating the electric switch 72 to switch from an off mode, in which the battery 70 is not in use, to an on mode, in which the battery 70 supplies electric energy for the operation of the blood clot removal device 10.
  • the electric switch 72 may be operated by energy supplied by the accumulator 58 to switch from an off mode, in which the wireless remote control is prevented from controlling the battery 70 to supply electric energy and is not in use, to a standby mode, in which the wireless remote control is permitted to control the battery 70 to supply electric energy for the operation of the blood clot removal device 10.
  • Fig. 23 shows an embodiment of the invention identical to that of Fig. 19, except that a motor 40, a mechanical reversing device in the form of a gear box 74, and an internal control unit 56 for controlling the gear box 74 also are implanted in the patient.
  • the internal control unit 56 controls the gear box 74 to reverse the function performed by the blood clot removal device 10 (mechanically operated).
  • Fig. 24 shows an embodiment of the invention identical to that of Fig. 22 except that the implanted components are interconnected differently.
  • the internal control unit 56 is powered by the battery 70 when the accumulator 58, suitably a capacitor, activates the electric switch 72 to switch to an on mode.
  • the electric switch 72 is in its on mode the internal control unit 56 is permitted to control the battery 70 to supply, or not supply, energy for the operation of the blood clot removal device 10.
  • Fig. 25 schematically shows conceivable combinations of implanted components of the apparatus for achieving various communication options. Basically, there are the blood clot removal device 10, the internal control unit 56, motor/pump unit 44, and the external energy transmission device 34 including the external wireless remote control. As already described above the wireless remote control transmits a control signal which is received by the internal control unit 56, which in turn controls the various implanted components of the apparatus.
  • a feedback device preferably in the form of a sensor 76, may be implanted in the patient for sensing a physical parameter of the patient, such as the pressure in a blood vessel.
  • the internal control unit 56 or alternatively the external wireless remote control of the external energy transmission device 34, may control the blood clot removal device 10 in response to signals from the sensor 76.
  • a transceiver may be combined with the sensor 76 for sending information on the sensed physical parameter to the external wireless remote control.
  • the wireless remote control may comprise a signal transmitter or transceiver and the internal control unit 56 may comprise a signal receiver or transceiver.
  • the wireless remote control may comprise a signal receiver or transceiver and the internal control unit 56 may comprise a signal transmitter or transceiver.
  • the above transceivers, transmitters and receivers may be used for sending information or data related to the blood clot removal device 10 from inside the patient's body to the outside thereof.
  • the senor 76 may be arranged to sense a functional parameter of the blood clot removal device 10.
  • the battery 70 may be equipped with a transceiver for sending information on the condition of the battery 70.
  • Fig. 26 shows an alternative embodiment wherein the blood clot removal device 10 is regulated from outside the patient's body.
  • the clot removal system 28 comprises a blood clot removal device 10 connected to a battery 70 via a subcutaneous switch 80.
  • the regulation of the blood clot removal device 10 is performed non-invasively by manually pressing the subcutaneous switch, whereby the operation of the blood clot removal device 10 is switched on and off.
  • the shown embodiment is a simplification and that additional components, such as an internal control unit, can be added to the clot removal system.
  • Fig. 27 shows an alternative embodiment, wherein the clot removal system 28 comprises a blood clot removal device 10 in fluid connection with a hydraulic fluid reservoir 52.
  • Non-invasive regulation is performed by manually pressing the hydraulic reservoir connected to the blood clot removal device 10.
  • a further embodiment of a system according to the invention comprises a feedback device for sending information from inside the patient's body to the outside thereof to give feedback information related to at least one functional parameter of the clot removal device or system or a physical parameter of the patient, thereby optimizing the performance of the system.
  • One preferred functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
  • FIG. 28 an arrangement is schematically illustrated for supplying an accurate amount of energy to a clot removal system 28 implanted in a patient, whose skin 36 is indicated by a vertical line.
  • a blood clot removal device 10 is connected to an implanted energy transforming device 30, likewise located inside the patient, preferably just beneath the patient's skin 36.
  • the implanted energy transforming device 30 may be placed in the abdomen, thorax, muscle fascia (e.g. in the abdominal wall), subcutaneously, or at any other suitable location.
  • the the implanted energy transforming device 30 is adapted to receive wireless energy E transmitted from an external energy source 34a provided in the external energy transmission device 34 located outside the patient's skin 36 in the vicinity of the implanted energy transforming device 30.
  • the wireless energy E may generally be transferred by means of any suitable Transcutaneous Energy Transfer (TET) device, such as a device including a primary coil arranged in the external energy source 34a and an adjacent secondary coil arranged in the implanted energy transforming device 30.
  • TET Transcutaneous Energy Transfer
  • a clot removal device e.g. after storing the incoming energy in an energy storing device or accumulator, such as a battery or a capacitor.
  • the present invention is generally not limited to any particular energy transfer technique, TET devices or energy storing devices, and any kind of wireless energy may be used.
  • the amount of transferred energy can be regulated by means of an external control unit 34b controlling the external energy source 34a based on the determined energy balance, as described above.
  • the energy balance and the required amount of energy can be determined by means of an internal control unit 56 connected to the blood clot removal device 10.
  • the internal control unit 56 may thus be arranged to receive various measurements obtained by suitable sensors or the like, not shown, measuring certain characteristics of the blood clot removal device 10, somehow reflecting the required amount of energy needed for proper operation of the blood clot removal device 10.
  • the current condition of the patient may also be detected by means of suitable measuring devices or sensors, in order to provide parameters reflecting the patient's condition.
  • Such characteristics and/or parameters may be related to the current state of the blood clot removal device 10, such as power consumption, operational mode and temperature, as well as the patient's condition reflected by, e.g., body temperature, blood pressure, heartbeats and breathing.
  • an energy storing device or accumulator 58 may optionally be connected to the implanted energy transforming device 30 for accumulating received energy for later use by the blood clot removal device 10.
  • characteristics of such an accumulator also reflecting the required amount of energy, may be measured as well.
  • the accumulator may be replaced by a battery, and the measured characteristics may be related to the current state of the battery, such as voltage, temperature, etc. In order to provide sufficient voltage and current to the blood clot removal device 10, and also to avoid excessive heating, it is clearly understood that the battery should be charged optimally by receiving a correct amount of energy from the implanted energy transforming device 30, i.e. not too little or too much.
  • the accumulator may also be a capacitor with corresponding characteristics.
  • battery characteristics may be measured on a regular basis to determine the current state of the battery, which then may be stored as state information in a suitable storage means in the internal control unit 56.
  • state information in a suitable storage means in the internal control unit 56.
  • the internal control unit 56 is adapted to determine the energy balance and/or the currently required amount of energy, (either energy per time unit or accumulated energy) based on measurements made by the above-mentioned sensors or measuring devices on the blood clot removal device 10, or the patient, or an energy storing device if used, or any combination thereof.
  • the internal control unit 56 is further connected to an internal signal transmitter 82, arranged to transmit a control signal reflecting the determined required amount of energy, to an external signal receiver 34c connected to the external control unit 34b. The amount of energy transmitted from the external energy source 34a may then be regulated in response to the received control signal.
  • sensor measurements can be transmitted directly to the external control unit 34b wherein the energy balance and/or the currently required amount of energy can be determined by the external control unit 34b, thus integrating the above- described function of the internal control unit 56 in the external control unit 34b.
  • the internal control unit 56 can be omitted and the sensor measurements are supplied directly to the internal signal transmitter 82 which sends the measurements over to the external signal receiver 34c and the external control unit 34b. The energy balance and the currently required amount of energy can then be determined by the external control unit 34b based on those sensor measurements.
  • the present solution employs the feed back of information indicating the required energy, which is more efficient than previous solutions because it is based on the actual use of energy that is compared to the received energy, e.g. with respect to the amount of energy, the energy difference, or the energy receiving rate as compared to the energy rate used by the clot removal device.
  • the clot removal device may use the received energy either for consuming or for storing the energy in an energy storage device or the like.
  • the different parameters discussed above would thus be used if relevant and needed and then as a tool for determining the actual energy balance. However, such parameters may also be needed per se for any actions taken internally to specifically operate the clot removal device.
  • the internal signal transmitter 82 and the external signal receiver 34c may be implemented as separate units using suitable signal transfer means, such as radio, IR (Infrared) or ultrasonic signals.
  • suitable signal transfer means such as radio, IR (Infrared) or ultrasonic signals.
  • the internal signal transmitter 82 and the external signal receiver 34c may be integrated in the implanted energy transforming device 30 and the external energy source 34a, respectively, so as to convey control signals in a reverse direction relative to the energy transfer, basically using the same transmission technique.
  • the control signals may be modulated with respect to frequency, phase or amplitude.
  • the energy supply arrangement illustrated in Fig. 28 may operate basically in the following manner.
  • the energy balance is first determined by the internal control unit 56.
  • a control signal reflecting the required amount of energy is also created by the internal control unit 56, and the control signal is transmitted from the internal signal transmitter 82 to the external signal receiver 34c.
  • the energy balance can be determined by the external control unit 34b instead depending on the implementation, as mentioned above.
  • the control signal may carry measurement results from various sensors.
  • the amount of energy emitted from the external energy source 34a can then be regulated by the external control unit 34b, based on the determined energy balance, e.g. in response to the received control signal. This process may be repeated intermittently at certain intervals during ongoing energy transfer, or may be executed on a more or less continuous basis during the energy transfer.
  • the amount of transferred energy can generally be regulated by adjusting various transmission parameters in the external energy source 34a, such as voltage, current, amplitude, wave frequency and pulse characteristics.
  • a method is thus provided for controlling transmission of wireless energy supplied to an electrically operable clot removal device implanted in a patient.
  • the wireless energy E is transmitted from an external energy source located outside the patient and is received by an internal energy receiver located inside the patient, the internal energy receiver being connected to the clot removal device for directly or indirectly supplying received energy thereto.
  • An energy balance is determined between the energy received by the internal energy receiver and the energy used for the clot removal device.
  • the transmission of wireless energy E from the external energy source is then controlled based on the determined energy balance.
  • a system for controlling transmission of wireless energy supplied to an electrically operable clot removal device implanted in a patient.
  • the system is adapted to transmit the wireless energy E from an external energy source located outside the patient which is received by an implanted energy transforming device located inside the patient, the implanted energy transforming device being connected to the clot removal device for directly or indirectly supplying received energy thereto.
  • the system is further adapted to determine an energy balance between the energy received by the implanted energy transforming device and the energy used for the clot removal device, and control the transmission of wireless energy E from the external energy source, based on the determined energy balance.
  • the functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
  • the external source of energy is controlled from outside the patient's body to release electromagnetic wireless energy, and released electromagnetic wireless energy is used for operating the blood clot removal device.
  • the external source of energy is controlling from outside the patient's body to release non-magnetic wireless energy, and released non-magnetic wireless energy is used for operating the blood clot removal device.
  • Figs. 13-29 could be combined in many different ways.
  • the electric switch 38 operated polarized energy could be incorporated in any of the embodiments of Figs. 15, 18-24
  • the hydraulic valve shifting device 54 could be incorporated in the embodiment of Fig. 16
  • the gear box 74 could be incorporated in the embodiment of Fig. 15.
  • FIG. 29 wherein an external switch 84 is interconnected between the external energy source 34a and an operation device, such as an electric motor regulating the blood clot removal device 10, by means of power lines 86 and 88.
  • An external control unit 34b controls the operation of the external switch to effect proper operation of the blood clot removal device 10.
  • the clot removal device can be placed surgically in the patient via a laparoscopic abdominal approach.
  • a tube is inserted into the abdomen of the patient's body and this tube is used to fill the patient's abdomen with gas, thereby expanding the patient's abdominal cavity.
  • At least two laparoscopic trocars are then placed in the patient's body, where after a camera is inserted through one of the trocars into the patient's abdomen.
  • At least one dissecting tool is inserted through a trocar and dissection is performed at two intended areas of the patient.
  • a clot removal device is placed in any part of the vascular system in the abdomen.
  • the clot removal device can be placed in the patient's thorax.
  • a tube is inserted into the thorax of the patient's body and this tube is used to fill the patient's thorax with gas, thereby expanding the patient's thoraxical cavity.
  • At least two laparoscopic trocars are then placed in the patient's body, where after a camera is inserted through one of the trocars into the patient's thorax.
  • At least one dissecting tool is inserted through a trocar and dissection is performed at two intended areas of the patient.
  • a clot removal device is placed in any part of the vascular system in the thorax.
  • An operation method for surgically placing a clot removal device starts with cutting the patient's skin and dissecting a placement area where to place the clot removal device inside the vascular system in the abdomen or thorax or retroperitoneal or subcutaneously or any limb of the patient. When a suitable place has been found, the clot removal device is placed in the placement area.
  • the clot removal device can then be used postoperatively and non-invasively without penetrating the patent's skin for removing any blood clots from the vascular system to outside thereof, while using energy from an energy source without any penetration through the patient's skin to power the blood clot removal device.
  • a method for surgically treating a patient needing a blood clot removal device in the vascular system in the patient's abdomen preferably comprises cutting an opening in the patient's abdominal wall and then dissecting an area of the vascular system.
  • a clot removal device is placed inside the vascular system, and the abdominal wall is sutured.
  • blood clots are moved away from the vascular system into an encapsulated closed bag in the patient's abdomen by means of the blood clot removal device.
  • blood clots are moved to the free abdomen.
  • a method for surgically treating a patient needing a blood clot removal device in the vascular system in the thorax comprises cutting an opening in the thorax wall and then dissecting the area of the vascular system.
  • a clot removal device is placed inside the vascular system, and the thorax wall is sutured.
  • a step of moving blood clots away from the vascular system can comprise moving blood clots either to a place that is free in the thorax, to a place that is free in the abdomen, or to a place that is encapsulated in a closed bag in the thorax.
  • a method of using a system for removing blood clots comprises implanting an implantable source of energy, such as an implanted energy transforming device 30 and an accumulator 58, in the patient.
  • An external source of energy such as an external energy transmission device 34, is provided for providing energy to the system.
  • This external source of energy is operated to release wireless energy, thereby non-invasively charging the implantable source of energy with the wireless energy, while controlling the implantable source of energy from outside the patient's body.
  • energy is releasing.
  • the wireless energy is preferably stored in the implantable source of energy.
  • the system for removing blood clots postoperatively and non- invasively regulates the clot removal device.
  • Any blood clots which have been accumulated in the vascular system of the patient's body, are moved away from the vascular system and are then placed outside the vascular system. This can be accomplished by an energy source, preferably repeatedly according to a preprogrammed time-schedule.
  • the movement of any blood clots away from the vascular system and placement of the blood clots outside the vascular system are preferably repeated and at least partly controlled by an internal control unit getting input from a sensor sensing any physical parameter of the patient or any functional parameter of the device.
  • the blood clot removal device has been described as an artificial device insertable in an artificial blood vessel of the patient.
  • the blood clot removal device is an artificial device adapted to be placed between two open ends of a blood vessel of the patient or be placed inside or attached to a blood vessel via surgery.
  • the blood clot removal device has been described to be placed in the patient's abdomen or thorax. It could also be adapted to be placed in the patient's retroperitoneal region or cephalic or neck region or any limb of the patient.
  • the filter in the blood clot removal device may be exchanged and replaced with a new fresh filter when it becomes dirty.
  • a new fresh filter when it becomes dirty.
  • a cassette 127 for holding filters is shown.
  • the cassette 27 comprises a revolving cylinder 129 having segments 130 each holding a filter.
  • the cylinder 129 is tightly sealed between two supports 131 holding the cylinder 129 in place and providing a tight sealing.
  • Preferable are the contacting surfaces made of ceramics to seal the surfaces with fine tolerances.
  • the blood flow passageway of an implantable blood clot removal apparatus passes through the cassette 127.
  • the cassette is driven by a motor 133 causing the cylinder 129 to revolve at suitable times.
  • the filter is designed to move any collected blood clots out from the blood flow passageway together with revolving filter, when the filter leaves the blood flow passageway to be replaced with a new filter.
  • the filter may be any kind of filter preferable with a space for the collected blood clots or blood clots adherent to the filter itself. Such a space to both the sealing plates when rotating, should preferable be larger before the filter seen in the blood flow passageway.
  • the motor is powered by a power supply 123b.
  • the power supply can be a power supply like the power supplies 123 or 123 a.
  • the power supplies 123, 123 a and 123b is the one and same power supply.
  • the power supply 123b can receive wireless energy in a suitable form, including but not limited to inductive energy ultrasonic energy, light energy or any other form of wireless energy set out above.
  • the energy is supplied by an external wireless energy transmitter 6 adapted to transmit energy through the skin 5 of a patient having the cassette 127 implanted.
  • the power supply 132b can also comprise a control unit as described above for controlling the revolving cassette 127.
  • the control unit can provide feedback to the outside and receive input data from an external transceiver 7 in a manner similar to the control unit used in conjunction with control of the pump.
  • Fig. 30b the cassette 127 is shown from the side with the supports 131 and the revolving cylinder spaced apart is a disassembled view.
  • Fig. 31a an alternative embodiment of the cassette 127 is shown.
  • the view in Fig. 30a is similar to the view in Fig. 31a.
  • a magazine 135 having a number of cylinders 129 stored therein is provided.
  • a cylinder 129 can by replaced by shifting the cylinders in the magazine 135.
  • the cylinders are shifted by pressurized air or a motor.
  • the filter is then first replaced in the blood flow passageway and thereafter in a position outside the blood flow passageway replaced in the cassette.
  • Such a replacement could preferable take place by having a number of filters in the cylinder 135 on one side of the cassette marked with 135 and moving the dirty filters out from the cassette into the cylinder on the other side of the cassette.
  • the cylinder 135 is instead a cleaning device adapted to clean the filter at a position outside the blood flow passageway.
  • Fig. 31b the cassette 127 is shown from the side with the supports 131 and the revolving cylinder spaced apart is a disassembled view.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • External Artificial Organs (AREA)

Abstract

A blood clot removal device for removing blood clots from the vascular system of a patient is implantable in the patient's body. The blood clot removal device comprises a blood flow passageway, a filter provided in the blood flow passageway for filtering blood clots, and a cleaning device for cleaning the filter. By means of such blood clot removal device and system, the risk of blood clots reaching sensitive areas of the patient's body, such as the brain, is reduced.

Description

BLOOD CLOT REMOVAL DEVICE, SYSTEM, AND METHOD
FIELD OF INVENTION
The present invention relates generally to a device and a system implantable in a blood flow passageway of a human or mammal patient for removing blood clots, and more particularly to a system for removing blood clots in a vascular system of the patient, one example being a heart pump system. The invention also relates to a method of removing blood clots.
BACKGROUND Today many implants are provided where the blood comes into contact with foreign material. All such implants have an associated risk of triggering blood clots. Such clots may become loose and may create severe damages at other parts of the body. Blood clots reaching the brain are the most dangerous ones and implants in the heart region may therefore be a first priority (although not limited to) of a blood clot removal system. One example of such implants and one example of use for the blood clot removal system may be heart help pumps. When a person has heart failure, his or her heart can't pump enough blood to meet the body's needs. In some cases, an advanced treatment such as a heart pump may be recommended. A heart pump takes over the function of one or both of the heart's lower chambers, with the potential to improve your symptoms and quality of life. Once considered a last resort for prolonging life until a donated heart became available, heart pumps have become a possible long-term treatment for selected people with heart failure.
A heart pump either takes over or assists the pumping role of the left ventricle - the heart's main pumping chamber. Part of the device, such as an electronic pump, is implanted in the heart and abdomen, and part, such as an electronic control unit, remains outside your body. An energy supply, such as a battery, can be provided either outside the body or be implanted.
One tube carries blood from the left ventricle of the heart and into the pump. Another tube takes blood pumped from the device into the artery to be circulated throughout the body. A heart pump can be a lifesaving treatment. However, the potential risks are serious, including the risk of having blood clots in the arteries leading from the heart.
Many other implants may be used together with the blood clot removal system. Basically any implant in contact with blood may be targets for the invention.
SUMMARY OF THE INVENTION
An object of the present invention is to provide a device, a system, and a method for removing blood clots in the vascular system of a patient.
The invention is based on the realization that a blood clot removal device can be implanted in a patient instead of being external of the patient.
According to a first aspect of the present invention there is provided a blood clot removal device for removing blood clots from the vascular system of a patient, the blood clot removal device being implantable in the patient's body and comprising a blood flow passageway, a filter provided in the blood flow passageway for filtering blood clots, and a cleaning device for cleaning the filter. One possibility is to clean the filter mechanically.
The cleaning device preferably is adapted to move blood clots away from the blood flow passageway to a place free inside the patient's body, where the body itself will take care of the blood clots. Alternatively, a collecting volume, such as a bag, is provided for collecting cleaned blood that has been mechanically cleaned from the filter. Most likely such a bag will then be placed inside the body.
In a preferred embodiment, the cleaning device is adapted to slice, push or scratch away any clots from the filter, but the cleaning device can also suck away any clots from the filter.
In one embodiment, the cleaning device comprises a first piston, with preferably is provided with a first recess in an outer end portion thereof to collect blood clots removed from the filter. By providing the first piston with a plurality of channels for accommodating the filter in an extended position of the first piston, it can surround the filter, ensuring essentially complete removal of blood clots therefrom. This is preferably effected if the first piston is movable in a direction perpendicular to the direction of the blood flow passageway.
The movement of the first piston can be controlled by a source of pressurized air, ensuring rapid acceleration of the first piston and thereby short cleaning cycles. The movement of the first piston can alternatively be controlled by an electric motor, a solenoid or the like.
The filter is of biocompatible material in order to avoid unnecessary interference with the blood environment.
In one embodiment, the blood clot removal device is used in a system comprising a heart pump connected to the blood flow passageway, wherein a first tube preferably connects the heart pump to the left ventricle of the patient's heart and a second tube connects the heart pump connected to the patient's aorta.
The filter preferably comprises a plurality of strips, which may be equally spaced to form a filter for blood clots. In order to achieve a filtering function, the distance between two adjacent strips is preferably less than 2 millimeters, and even more preferably less than 1.0 millimeter. The distance depends on which size blood clots you want to avoid.
In one embodiment, a second piston is provided across the blood flow passageway from the first piston, wherein the second piston is movable in a direction essentially perpendicular to the direction of the blood flow passageway and spring biased in the direction of the first piston. If an outer end portion of the second piston is provided with a second recess, the first piston and the second piston cooperate to catch blood clots for further removal. This further removal can be accomplished by means of a third piston, which is movable in a direction perpendicular to both the direction of the blood flow passageway and the direction of movement of the first piston and of the second piston.
In a preferred embodiment, the blood flow passageway of the blood clot removal device has an essentially square cross-sectional shape, which provides for a laminated flow of the blood, particularly if the square shape is combined with a filter comprising parallel strips.
The blood clot removal device is in a preferred embodiment insertable in a blood vessel of the patient, preferably via surgery.
The blood clot removal device can be adapted to be placed in the patient's abdomen or thorax.
The blood clot removal device is preferably comprised in a system for removing blood clots of a patient. This system can comprise a switch, preferably a subcutaneous switch being adapted to manually and non-invasively control any function of the blood clot removal device.
The system for removing blood clots preferably comprises a hydraulic device having a hydraulic reservoir, wherein the blood clot removal device is adapted to non- invasively be regulated by manually pressing the hydraulic reservoir.
A wireless remote control can non-invasively regulate any function of the blood clot removal device. Even more important any function of the device may be programmable by such a remote control.
Also, a wireless energy transmitter can non-invasively energize the blood clot removal device.
An energy source is preferably adapted to power the blood clot removal device. The energy source can comprise an internal energy source, such as an internal energy source adapted to receive energy from an external energy source transmitting energy in a wireless mode. The internal energy source can then be charged from the energy in the wireless mode.
The system preferably comprises a feedback device for sending information from inside the patient's body to the outside thereof to give feedback information related to at least one functional parameter of the device or a physical parameter of the patient, thereby optimizing the performance of the system. One preferred functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
The system preferably comprises an operation device for operating the blood clot removal device. This operation device can comprise a motor or a pump, an electrically powered operation device, a hydraulic operation device, or an electric motor.
To improve the performance of the system for removing blood clots, a physical parameter sensor, such as a pressure sensor, is provided for sensing a physical parameter of the patient. An internal control unit can act in response to the physical parameter sensed by the sensor.
A functional parameter sensor sensing a functional parameter of the blood clot removal device can also be provided. An internal control unit acting in response to the functional parameter sensed by the sensor can also be provided.
A method of using the system for removing blood clots is also provided, wherein at least one function of the blood clot removal device is regulated from outside the patient's body. The regulation is in a preferred embodiment non-invasively by manually pressing a subcutaneous switch. In an alternative embodiment, non- invasively regulation are performed by manually pressing a hydraulic reservoir connected to the blood clot removal device.
Alternatively, the system for removing blood clots comprises a wireless remote " control, wherein non-invasively regulation is performed using said remote control.
In a preferred embodiment, the system for removing blood clots comprises a wireless energy transmitter, wherein non-invasively regulation is performed using said energy transmitter.
Preferably, an energy source is used for powering and adjusting any function of the blood clot removal device. The energy source may comprise an internal energy source, which preferably is associated with an external energy source adapted to transmit wireless energy. Energy is preferably transmitted from the external energy source to charge the internal energy source. Feedback information is preferably sent from inside the body to the outside thereof to give feed back related to the functional parameters of the device or physical parameters of the patient. The functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
In one embodiment, wireless energy is transmitted for powering the operation device.
In a preferred embodiment, the method of using a system for removing blood clots comprises the steps of: implanting an implantable source of energy in the patient, providing an external source of energy, controlling the external source of energy to release wireless energy, charging non-invasively the implantable source of energy with the wireless energy, controlling the implantable source of energy from outside the patient's body, and releasing energy for use in connection with operation of the blood clot removal device. The wireless energy is preferably stored in the implantable source of energy.
In another preferred embodiment, the method of using a system for removing blood clots comprises the steps of: providing an external source of energy outside the patient's body, and controlling the external source of energy from outside the patient's body to release wireless energy, and using released wireless energy for operating the operation device. The wireless energy is preferably transformed into electrical energy inside the patient's body using an implanted energy-transforming device and using the electrical energy when operating the blood clot removal device.
In one embodiment, the electrical energy is used directly in connection with operation of the blood clot removal device, as a transforming device transforms the wireless energy into the electrical energy.
In another embodiment, the external source of energy is controlling from outside the patient's body to release non-magnetic wireless energy, and released non-magnetic wireless energy is used for operating the blood clot removal device. In yet an alternative embodiment, the external source of energy is controlled from outside the patient's body to release electromagnetic wireless energy, and released electromagnetic wireless energy is used for operating the blood clot removal device.
A method for placing a blood clot removal device, comprising a surgical method via a laparoscopic abdominal approach, comprises the steps of: inserting a needle or tube like instrument into the abdomen of the patient's body, using the needle or tube like instrument to fill the patient's abdomen with gas thereby expanding the patient's abdominal cavity, placing at least two laparoscopic trocars in the patient's body, inserting a camera through one of the trocars into the patient's abdomen, inserting at least one dissecting tool through a trocar and dissecting the intended placement area of the patient, placing at least one blood clot removal device in any part of the vascular system in the abdomen, moving blood clots away from the vascular system post operatively to a different part of the body, and powering the device with a source of energy. The blood clots can be moved either to a place that is free in the abdomen, to a place that is free in the abdomen, or to a place that is encapsulated in a closed bag in the abdomen
The blood clot removal device is preferably programmable from outside the patients body. By adding the steps of sensing a physical parameter of the patient or a functional parameter of the device, and sending sensing information to an internal control unit adapted for regulating said blood clot removal device, performance is improved.
A method of placing a blood clot removal device, comprising a surgical method via a laparoscopic thoraxial approach, comprises the steps of: inserting a needle or tube like instrument into the thorax of the patients body, using the needle or tube like instrument to fill the thorax with gas thereby expanding the thoraxical cavity, placing at least two laparoscopic trocars in the patient's body, inserting a camera through one of the trocars into the thorax, inserting at least one dissecting tool through a trocar and dissecting the intended area of the patient, placing at least one blood clot removal device in any part of the vascular system in the thorax, moving blood clots away from vascular system post operatively to a different part of the body, and powering the device with a source of energy. The blood clots can be moved either to a place that is free in the thorax, to a place that is free in the abdomen, or to a place that is encapsulated in a closed bag in the thorax
The device is preferably programmed from outside the body of the patient.
A method for surgically treating a patient needing a blood clot removal device in the vascular system in the patient's abdomen comprises the steps of: cutting an opening in the patient's abdominal wall, dissecting an area of the vascular system, placing a blood clot removal device inside the vascular system, and suturing said abdominal wall. In one embodiment, blood clots are moved away from the vascular system into an encapsulated closed bag in the patient's abdomen by means of the blood clot removal device. In another embodiment, blood clots are moved to the free abdomen.
A method for surgically treating a patient needing a blood clot removal device in the vascular system in the thorax comprises the steps of: cutting an opening in the thorax wall, dissecting the area of the vascular system, placing a blood clot removal device inside the vascular system, and suturing said thorax wall. A step of moving blood clots away from the vascular system can comprise moving blood clots either to a place that is free in the thorax, to a place that is free in the abdomen, or to a place that is encapsulated in a closed bag in the thorax
A method using an system for removing blood clots, for postoperatively and non- invasively regulating the blood clot removal device, comprises the steps of: moving any blood clots, which have been accumulated in the vascular system of the patient's body, away from the vascular system, and placing the blood clots outside the vascular system. This can be accomplished by an energy source, preferably repeatedly according to a pre-programmed time-schedule. The steps of moving any blood clots away from the vascular system and placing the blood clots outside the vascular system are preferably repeated and at least partly controlled by an internal control unit getting input from a sensor sensing any physical parameter of the patient or any functional parameter of the device. The accumulation of blood clots in the filter may be visualized with light sensors, sensors measuring any electrical parameter, any blood flow measurement, pressure difference before and after the filter or any other kind of sensor. An operation method for surgically placing a blood clot removal device comprises the steps of: cutting the patient's skin, dissecting a placement area where to place the blood clot removal device inside the vascular system in the abdomen or thorax or retroperitoneal or subcutaneously or any limb of the patient, placing the blood clot removal device in the placement area, removing, postoperatively and non-invasively without penetrating the patent's skin, any blood clots from the vascular system to outside thereof, and using energy from an energy source without any penetration through the patient's skin to power the blood clot removal device.
Further preferred embodiments are defined by the dependent claims.
BRIEF DESCRIPTION OF DRAWINGS
The invention is now described, by way of example, with reference to the accompanying drawings, in which:
Fig. 1 is an overview of the body of a patient having an implanted heart pump.
Fig. 2 is a sectional view of a clot removal device according to the invention.
Fig. 3 is a cross sectional view of the clot removal device of Fig. 2 taken along the line III-III before a cleaning operation.
Fig. 4 is a sectional view of the clot removal device of Fig. 2 taken along the line IV-IV.
Fig. 5 is a sectional view similar to that of Fig. 2 showing blood clots before a clot removal operation.
Fig. 6 is a sectional view similar to that of Fig. 2 during a first step of a clot removal operation.
Fig. 7 is a sectional view similar to that of Fig. 2 during a second step of a clot removal operation.
Fig. 8 is a sectional view similar to that of Fig. 2 during a third step of a clot removal operation. Fig. 9 is a cross sectional view similar to that of Fig. 3 but during a cleaning operation.
Fig. 10 is a sectional view of the clot removal device of Fig. 8 taken along the line X-X showing a clot ejection piston before ejection of clots.
Fig. 11 is a view similar to that of Fig. 9 but after ejection of clots.
Fig. 12 is an overall view of a clot removal system according to the invention.
Fig. 13 is a schematic diagram of the system of Fig. 12.
Figs. 14-29 show various embodiments based on the system of Fig. 13.
Figs. 30a and 30b are views of a filter cassette.
Figs. 31a and 3 Ib are views of a filter cassette.
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
In the following a detailed description of preferred embodiments of the present invention will be given. In the drawing figures, like reference numerals designate identical or corresponding elements throughout the several figures. It will be appreciated that these figures are for illustration only and are not in any way restricting the scope of the invention. Thus, any references to direction, such as "up" or "down", are only referring to the directions shown in the figures. Also, any dimensions etc. shown in the figures are for illustration purposes.
Fig.l shows a patient 1 having an implanted heart pump 2. The implanted heart pump 2 is connected to the left ventricle 3a of the patient's heart 3 by means of a first tube 2a. The heart pump 2 is also connected to the aorta, generally designated 4, of the patient 1 by means of a second tube 2b. In this way, during operation the heart pump supplements or replaces the blood pumping operation of the patient's heart 3.
A blood clot removal device 10 according to the invention is shown provided in the second tube 2b of the heart pump 2, i.e., in the tube leading to the aorta 4 of the patient 1. This means that part of the blood flow passageway provided by the second tube 2b is replaced by a blood flow passageway in the blood clot removal device 10. The blood clot removal device 10 is thus an artificial device insertable in an artificial blood vessel of the patient. The function of the clot removal device is to remove any blood clots in the blood transported by the second tube 2b. These blood clots are preferably moved to a place free inside the body of the patient. However, they could alternatively be collected in a collecting volume, such as a bag 10a connected to the blood clot removal device 10 for subsequent removal or storage. A preferred storage capacity of the bag 10a can be more than 100 milliliters, for example. The blood clot removal device is an artificial device but could be inserted directly into a blood vessel of the patient or connected between two ends of a blood vessel.
The clot removal device is preferably insertable in a blood flow passageway of the patient via surgery and is placed in the patient's abdomen or thorax or cephalic or neck region or retroperitoneal or any limb of the patient.
The design of a first preferred embodiment of the blood clot removal device 10 will now be described in detail, with reference to Figs. 2-4. Fig. 2 shows a sectional view wherein the blood clot removal device 10 is provided in the blood flow passageway provided by the second tube 2b. A filter 12 is provided across the blood flow passageway 14 formed in a housing 11 with the function of stopping potential blood clots brought forward in the second tube 2b by the blood flow, indicated by arrows in the figure. In this preferred embodiment, the filter 12 comprises a plurality of preferably equally spaced strips 12a of some suitable material, such as biocompatible metal or plastic. These strips 12a are preferably arranged mutual parallel.
The distance between two adjacent strips is small enough to stop any blood clots. Thus, the distance is preferably less than 2 millimeters, and even more preferably less than 1.0 millimeters, but if the goal is to protect the brain from larger clots only the distance could be larger. Although the blood flow passageway 14 in the preferred embodiment has an essentially square cross-sectional shape, it will be realized that it can take any suitable shape, such as rectangular or circular.
By providing a plurality of strips 12a as a filter across the blood flow passageway 14, a laminar blood flow is achieved downstream of the filter, which is advantageous in a blood clot preventing perspective. The blood flow configuration can be further enhanced by giving the plurality of strips 12a a desired cross-sectional shape, although the rectangular shape shown in Fig. 4 will be adequate for most purposes.
A first piston 16 is provided movable in a direction essentially perpendicular to the direction of the blood flow passageway 14, i.e., essentially perpendicular to the direction of the blood flow. This first piston 16 is driven by some suitable actuator means, such as pressurized air, a solenoid arrangement, an electrical servo motor or the like. A motor could be used to build up a stored power that could be released very fast, one example being a spring. In the preferred embodiment, pressurized air acts as the actuator means, since by latching the piston by means of a suitable latching means for the piston, building up the air pressure, and subsequently releasing the piston, very high speed of the piston is achieved, with enables short cleaning times of the filter.
The outer end portion of the first piston 16, i.e., the end portion facing the blood flow passageway 14, is essentially flush with the wall of the blood flow passageway in a non-active state of the blood clot removal device 10. Also, the outer end portion is provided with a concave portion or recess 16a (exaggerated in the figures) in order to act as a blood clot capturing means, as will be explained below.
The strike range of the first piston 16 is such that it extends all way across the blood flow passageway 14, as will be explained below with reference to Figs. 5-8. A number of channels 16b corresponding to the number of strips 12a is provided in the first piston 16 to accommodate the strips when the first piston is in an extended position.
The first piston 16 is also provided with a plurality of through holes 17 in the direction of the blood flow passageway. These through holes will allow blood to flow through the blood flow passageway also during a cleaning operation, as will be explained below with reference to Fig. 9.
A second piston 18 is provided across the blood flow passageway 14 from the first piston 16. Also this second piston 18 is movable in a direction essentially perpendicular to the direction of the blood flow passageway 14 and is biased in the direction thereof by means of a spring 18a, for example. Likewise, the outer end portion of the second piston is provided with a recess 18b similar to the recess 16a of the first piston 16.
The first and second pistons 16, 18, are sealed to the housing 11 by means of a respective sealing 20, such as an O sealing.
A preferred embodiment of the method according to the invention will now be described with reference to Figs. 5-8, showing different operational steps of the above-described device. Fig. 5 is a view similar to that of Fig. 2. However, this figures shows the blood clot removal device 10 during operation, wherein blood clots, generally designated 22, have assembled on the filter 12.
In Fig. 6, the first piston 16 has moved linearly from the retracted starting position shown Fig. 5 to an extended position, wherein the outer end portion thereof is in contact with the second piston 18. Due to the recess 16a in the outer end of the first piston 16, the blood clots 22 have been assembled in the recess 16a, whereby they have been brought with the first piston 16 during the movement thereof. In the step shown in Fig. 6, the blood clots are confined in the recess 16a between the first and second pistons 16, 18.
By moving the first piston 16 an additional distance from the position shown in Fig. 6, the second piston 18 is pushed against the force of the spring 18a to a fully retracted position, see Fig. 7. The plurality of strips 12a is in this position fully received in a respective channel 16b in the first piston. It is seen that the outer ends of the first and second pistons define an unobstructed cavity in which the blood clots are confined. It is thereby possible to remove these by some suitable means. One such means could be a third piston 24, which is movable in a direction perpendicular to both the direction of the blood flow passageway 14 and the direction of movement of the first and second pistons 16, 18. This third piston, the movement of which could be controlled by means of pressurized air, a solenoid, an electric motor etc., scrapes off the blood clots collected by the first piston 16 and moves them to a place outside of the blood clot removal device 10 and the blood flow passageway 14. Fig. 9 shows a side view of the first piston 16 in a fully extended position, i.e., corresponding to the view of Fig. 8. It is here seen that in this position the through holes 17 will be aligned with the blood flow passageway 14, thereby allowing blood to flow therethrough also during cleaning of the filter 12.
Fig. 10 shows a cross-sectional view taken along line X-X of Fig. 8. It is here seen that the third piston 24 collects the blood clots 22 during a downward movement, indicated by an arrow in the figure. The clots are ejected from the blood clot removal device 10 when the third piston 24 has reached its lower end position, shown in Fig. 11.
Again with reference to Fig. 7, it will be realized that pressurized air can be used for ejecting the collected blood clots from the cavity formed by the first piston 16 and the second piston 18.
A clot removal system, generally designated 28 and comprising a clot removal device as described above will now be described with reference to Figs. 12-25.
The system of Fig. 12 comprises a blood clot removal device 10 placed in the abdomen of the patient. An internal energy source in the form of an implanted energy transforming device 30 is adapted to supply energy consuming components of the blood clot removal device 10 with energy via a power supply line 32. An external energy transmission device 34 includes a wireless remote control transmitting a wireless signal, which is received by a signal receiver incorporated in the implanted energy transforming device 30. The implanted energy transforming device 30 transforms energy from the signal into electric energy which is supplied via the power supply line 32.
The system of Fig. 12 is shown in a more generalized block diagram form in Fig. 13, wherein the patient's skin 36, generally shown by a vertical line, separates the interior of the patient to the right of the line from the exterior to the left of the line.
Fig. 14 shows an embodiment of the invention identical to that of Fig. 13, except that a reversing device in the form of an electric switch 38 operable by polarized energy also is implanted in the patient for reversing the blood clot removal device 10. The wireless remote control of the external energy transmission device 34 transmits a wireless signal that carries polarized energy and the implanted energy transforming device 30 transforms the wireless polarized energy into a polarized current for operating the electric switch 38. When the polarity of the current is shifted by the implanted energy transforming device 30 the electric switch 38 reverses the function performed by the blood clot removal device 10.
Fig. 15 shows an embodiment of the invention identical to that of Fig. 13, except that an operation device 40 implanted in the patient for regulating the blood clot removal device 10 is provided between the implanted energy transforming device 30 and the blood clot removal device 10. This operation device can be in the form of a motor 40, such as an electric servo motor. The motor 40 is powered with energy from the implanted energy transforming device 30, as the remote control of the external energy transmission device 34 transmits a wireless signal to the receiver of the implanted energy transforming device 30.
Fig. 16 shows an embodiment of the invention identical to that of Fig. 13, except that it also comprises an operation device is in the form of an assembly 42 including a motor/pump unit 78 and a fluid reservoir 46 is implanted in the patient. In this case the blood clot removal device 10 is hydraulically operated, i.e. hydraulic fluid is pumped by the motor/pump unit 44 from the fluid reservoir 46 through a conduit 48 to the blood clot removal device 10 to operate the clot removal device, and hydraulic fluid is pumped by the motor/pump unit 44 back from the blood clot removal device 10 to the fluid reservoir 46 to return the clot removal device to a starting position. The implanted energy transforming device 30 transforms wireless energy into a current, for example a polarized current, for powering the motor/pump unit 44 via an electric power supply line 50.
Instead of a hydraulically operated blood clot removal device 10, it is also envisaged that the operation device comprises a pneumatic operation device. In this case, pressurized air can be used for regulation and the fluid reservoir is replaced by an air chamber and the fluid is replaced by air. Fig. 17 shows an embodiment of the invention comprising the external energy transmission device 34 with its wireless remote control, the blood clot removal device 10, in this case hydraulically operated, and the implanted energy transforming device 30, and further comprising a hydraulic fluid reservoir 52, a motor/pump unit 44 and an reversing device in the form of a hydraulic valve shifting device 54, all implanted in the patient. The motor of the motor/pump unit 44 is an electric motor. In response to a control signal from the wireless remote control of the external energy transmission device 34, the implanted energy transforming device 30 powers the motor/pump unit 44 with energy from the energy carried by the control signal, whereby the motor/pump unit 44 distributes hydraulic fluid between the hydraulic fluid reservoir 52 and the blood clot removal device 10. The remote control of the external energy transmission device 34 controls the hydraulic valve shifting device 54 to shift the hydraulic fluid flow direction between one direction in which the fluid is pumped by the motor/pump unit 44 from the hydraulic fluid reservoir 52 to the blood clot removal device 10 to operate the clot removal device, and another opposite direction in which the fluid is pumped by the motor/pump unit 44 back from the blood clot removal device 10 to the hydraulic fluid reservoir 52 to return the clot removal device to a starting position.
Fig. 18 shows an embodiment of the invention identical to that of Fig. 13, except that an internal control unit 56 controlled by the wireless remote control of the external energy transmission device 34, an accumulator 58 and a capacitor 60 also are implanted in the patient. The internal control unit 56 arranges storage of electric energy received from the implanted energy transforming device 30 in the accumulator 58, which supplies energy to the blood clot removal device 10. In response to a control signal from the wireless remote control of the external energy transmission device 34, the internal control unit 56 either releases electric energy from the accumulator 58 and transforms the released energy via power lines 62 and 64, or directly transforms electric energy from the implanted energy transforming device 30 via a power line 66, the capacitor 60, which stabilizes the electric current, a power line 68 and the power line 64, for the operation of the blood clot removal device 10. The internal control unit is preferably programmable from outside the patient's body. In a preferred embodiment, the internal control unit is programmed to regulate the blood clot removal device 10 to remove any blood clots from the vascular system and place the blood clots outside the vascular system repeatedly according to a pre- programmed time-schedule.
In accordance with an alternative, the capacitor 60 in the embodiment of Fig. 18 may be omitted. In accordance with another alternative, the accumulator 58 in this embodiment may be omitted.
Fig. 19 shows an embodiment of the invention identical to that of Fig. 13, except that a battery 70 for supplying energy for the operation of the blood clot removal device 10 and an electric switch 72 for switching the operation of the blood clot removal device 10 also are implanted in the patient. The electric switch 72 is operated by the energy supplied by the implanted energy transforming device 30 to switch from an off mode, in which the battery 70 is not in use, to an on mode, in which the battery 70 supplies energy for the operation of the blood clot removal device 10.
Fig. 20 shows an embodiment of the invention identical to that of Fig. 19, except that an internal control unit 56 controllable by the wireless remote control of the external energy transmission device 34 also is implanted in the patient. In this case, the electric switch 72 is operated by the energy supplied by the implanted energy transforming device 30 to switch from an off mode, in which the wireless remote control is prevented from controlling the internal control unit 56 and the battery is not in use, to a standby mode, in which the remote control is permitted to control the internal control unit 56 to release electric energy from the battery 70 for the operation of the blood clot removal device 10.
Fig. 21 shows an embodiment of the invention identical to that of Fig. 20, except that an accumulator 58 is substituted for the battery 70 and the implanted components are interconnected differently. In this case, the accumulator 58 stores energy from the implanted energy transforming device 30. In response to a control signal from the wireless remote control of the external energy transmission device 34, the internal control unit 56 controls the electric switch 72 to switch from an off mode, in which the accumulator 58 is not in use, to an on mode, in which the accumulator 58 supplies energy for the operation of the blood clot removal device 10.
Fig. 22 shows an embodiment of the invention identical to that of Fig. 21, except that a battery 70 also is implanted in the patient and the implanted components are interconnected differently. In response to a control signal from the wireless remote control of the external energy transmission device 34, the internal control unit 56 controls the accumulator 58 to deliver energy for operating the electric switch 72 to switch from an off mode, in which the battery 70 is not in use, to an on mode, in which the battery 70 supplies electric energy for the operation of the blood clot removal device 10.
Alternatively, the electric switch 72 may be operated by energy supplied by the accumulator 58 to switch from an off mode, in which the wireless remote control is prevented from controlling the battery 70 to supply electric energy and is not in use, to a standby mode, in which the wireless remote control is permitted to control the battery 70 to supply electric energy for the operation of the blood clot removal device 10.
Fig. 23 shows an embodiment of the invention identical to that of Fig. 19, except that a motor 40, a mechanical reversing device in the form of a gear box 74, and an internal control unit 56 for controlling the gear box 74 also are implanted in the patient. The internal control unit 56 controls the gear box 74 to reverse the function performed by the blood clot removal device 10 (mechanically operated).
Fig. 24 shows an embodiment of the invention identical to that of Fig. 22 except that the implanted components are interconnected differently. Thus, in this case the internal control unit 56 is powered by the battery 70 when the accumulator 58, suitably a capacitor, activates the electric switch 72 to switch to an on mode. When the electric switch 72 is in its on mode the internal control unit 56 is permitted to control the battery 70 to supply, or not supply, energy for the operation of the blood clot removal device 10. Fig. 25 schematically shows conceivable combinations of implanted components of the apparatus for achieving various communication options. Basically, there are the blood clot removal device 10, the internal control unit 56, motor/pump unit 44, and the external energy transmission device 34 including the external wireless remote control. As already described above the wireless remote control transmits a control signal which is received by the internal control unit 56, which in turn controls the various implanted components of the apparatus.
A feedback device, preferably in the form of a sensor 76, may be implanted in the patient for sensing a physical parameter of the patient, such as the pressure in a blood vessel. The internal control unit 56, or alternatively the external wireless remote control of the external energy transmission device 34, may control the blood clot removal device 10 in response to signals from the sensor 76. A transceiver may be combined with the sensor 76 for sending information on the sensed physical parameter to the external wireless remote control. The wireless remote control may comprise a signal transmitter or transceiver and the internal control unit 56 may comprise a signal receiver or transceiver. Alternatively, the wireless remote control may comprise a signal receiver or transceiver and the internal control unit 56 may comprise a signal transmitter or transceiver. The above transceivers, transmitters and receivers may be used for sending information or data related to the blood clot removal device 10 from inside the patient's body to the outside thereof.
Alternatively, the sensor 76 may be arranged to sense a functional parameter of the blood clot removal device 10.
Where the motor/pump unit 44 and battery 70 for powering the motor/pump unit 44 are implanted, the battery 70 may be equipped with a transceiver for sending information on the condition of the battery 70.
Fig. 26 shows an alternative embodiment wherein the blood clot removal device 10 is regulated from outside the patient's body. The clot removal system 28 comprises a blood clot removal device 10 connected to a battery 70 via a subcutaneous switch 80. Thus, the regulation of the blood clot removal device 10 is performed non-invasively by manually pressing the subcutaneous switch, whereby the operation of the blood clot removal device 10 is switched on and off. It will be appreciated that the shown embodiment is a simplification and that additional components, such as an internal control unit, can be added to the clot removal system.
Fig. 27 shows an alternative embodiment, wherein the clot removal system 28 comprises a blood clot removal device 10 in fluid connection with a hydraulic fluid reservoir 52. Non-invasive regulation is performed by manually pressing the hydraulic reservoir connected to the blood clot removal device 10.
A further embodiment of a system according to the invention comprises a feedback device for sending information from inside the patient's body to the outside thereof to give feedback information related to at least one functional parameter of the clot removal device or system or a physical parameter of the patient, thereby optimizing the performance of the system.
One preferred functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
In Fig. 28, an arrangement is schematically illustrated for supplying an accurate amount of energy to a clot removal system 28 implanted in a patient, whose skin 36 is indicated by a vertical line. A blood clot removal device 10 is connected to an implanted energy transforming device 30, likewise located inside the patient, preferably just beneath the patient's skin 36. Generally speaking, the implanted energy transforming device 30 may be placed in the abdomen, thorax, muscle fascia (e.g. in the abdominal wall), subcutaneously, or at any other suitable location. The the implanted energy transforming device 30 is adapted to receive wireless energy E transmitted from an external energy source 34a provided in the external energy transmission device 34 located outside the patient's skin 36 in the vicinity of the implanted energy transforming device 30.
As is well known in the art, the wireless energy E may generally be transferred by means of any suitable Transcutaneous Energy Transfer (TET) device, such as a device including a primary coil arranged in the external energy source 34a and an adjacent secondary coil arranged in the implanted energy transforming device 30. When an electric current is fed through the primary coil, energy in the form of a voltage is induced in the secondary coil which can be used to operate a clot removal device, e.g. after storing the incoming energy in an energy storing device or accumulator, such as a battery or a capacitor. However, the present invention is generally not limited to any particular energy transfer technique, TET devices or energy storing devices, and any kind of wireless energy may be used.
The amount of transferred energy can be regulated by means of an external control unit 34b controlling the external energy source 34a based on the determined energy balance, as described above. In order to transfer the correct amount of energy, the energy balance and the required amount of energy can be determined by means of an internal control unit 56 connected to the blood clot removal device 10. The internal control unit 56 may thus be arranged to receive various measurements obtained by suitable sensors or the like, not shown, measuring certain characteristics of the blood clot removal device 10, somehow reflecting the required amount of energy needed for proper operation of the blood clot removal device 10. Moreover, the current condition of the patient may also be detected by means of suitable measuring devices or sensors, in order to provide parameters reflecting the patient's condition. Hence, such characteristics and/or parameters may be related to the current state of the blood clot removal device 10, such as power consumption, operational mode and temperature, as well as the patient's condition reflected by, e.g., body temperature, blood pressure, heartbeats and breathing.
Furthermore, an energy storing device or accumulator 58 may optionally be connected to the implanted energy transforming device 30 for accumulating received energy for later use by the blood clot removal device 10. Alternatively or additionally, characteristics of such an accumulator, also reflecting the required amount of energy, may be measured as well. The accumulator may be replaced by a battery, and the measured characteristics may be related to the current state of the battery, such as voltage, temperature, etc. In order to provide sufficient voltage and current to the blood clot removal device 10, and also to avoid excessive heating, it is clearly understood that the battery should be charged optimally by receiving a correct amount of energy from the implanted energy transforming device 30, i.e. not too little or too much. The accumulator may also be a capacitor with corresponding characteristics.
For example, battery characteristics may be measured on a regular basis to determine the current state of the battery, which then may be stored as state information in a suitable storage means in the internal control unit 56. Thus, whenever new measurements are made, the stored battery state information can be updated accordingly. In this way, the state of the battery can be "calibrated" by transferring a correct amount of energy, so as to maintain the battery in an optimal condition.
Thus, the internal control unit 56 is adapted to determine the energy balance and/or the currently required amount of energy, (either energy per time unit or accumulated energy) based on measurements made by the above-mentioned sensors or measuring devices on the blood clot removal device 10, or the patient, or an energy storing device if used, or any combination thereof. The internal control unit 56 is further connected to an internal signal transmitter 82, arranged to transmit a control signal reflecting the determined required amount of energy, to an external signal receiver 34c connected to the external control unit 34b. The amount of energy transmitted from the external energy source 34a may then be regulated in response to the received control signal.
Alternatively, sensor measurements can be transmitted directly to the external control unit 34b wherein the energy balance and/or the currently required amount of energy can be determined by the external control unit 34b, thus integrating the above- described function of the internal control unit 56 in the external control unit 34b. In that case, the internal control unit 56 can be omitted and the sensor measurements are supplied directly to the internal signal transmitter 82 which sends the measurements over to the external signal receiver 34c and the external control unit 34b. The energy balance and the currently required amount of energy can then be determined by the external control unit 34b based on those sensor measurements.
Hence, the present solution employs the feed back of information indicating the required energy, which is more efficient than previous solutions because it is based on the actual use of energy that is compared to the received energy, e.g. with respect to the amount of energy, the energy difference, or the energy receiving rate as compared to the energy rate used by the clot removal device. The clot removal device may use the received energy either for consuming or for storing the energy in an energy storage device or the like. The different parameters discussed above would thus be used if relevant and needed and then as a tool for determining the actual energy balance. However, such parameters may also be needed per se for any actions taken internally to specifically operate the clot removal device.
The internal signal transmitter 82 and the external signal receiver 34c may be implemented as separate units using suitable signal transfer means, such as radio, IR (Infrared) or ultrasonic signals. Alternatively, the internal signal transmitter 82 and the external signal receiver 34c may be integrated in the implanted energy transforming device 30 and the external energy source 34a, respectively, so as to convey control signals in a reverse direction relative to the energy transfer, basically using the same transmission technique. The control signals may be modulated with respect to frequency, phase or amplitude.
To conclude, the energy supply arrangement illustrated in Fig. 28 may operate basically in the following manner. The energy balance is first determined by the internal control unit 56. A control signal reflecting the required amount of energy is also created by the internal control unit 56, and the control signal is transmitted from the internal signal transmitter 82 to the external signal receiver 34c. Alternatively, the energy balance can be determined by the external control unit 34b instead depending on the implementation, as mentioned above. In that case, the control signal may carry measurement results from various sensors. The amount of energy emitted from the external energy source 34a can then be regulated by the external control unit 34b, based on the determined energy balance, e.g. in response to the received control signal. This process may be repeated intermittently at certain intervals during ongoing energy transfer, or may be executed on a more or less continuous basis during the energy transfer.
The amount of transferred energy can generally be regulated by adjusting various transmission parameters in the external energy source 34a, such as voltage, current, amplitude, wave frequency and pulse characteristics. A method is thus provided for controlling transmission of wireless energy supplied to an electrically operable clot removal device implanted in a patient. The wireless energy E is transmitted from an external energy source located outside the patient and is received by an internal energy receiver located inside the patient, the internal energy receiver being connected to the clot removal device for directly or indirectly supplying received energy thereto. An energy balance is determined between the energy received by the internal energy receiver and the energy used for the clot removal device. The transmission of wireless energy E from the external energy source is then controlled based on the determined energy balance.
A system is also provided for controlling transmission of wireless energy supplied to an electrically operable clot removal device implanted in a patient. The system is adapted to transmit the wireless energy E from an external energy source located outside the patient which is received by an implanted energy transforming device located inside the patient, the implanted energy transforming device being connected to the clot removal device for directly or indirectly supplying received energy thereto. The system is further adapted to determine an energy balance between the energy received by the implanted energy transforming device and the energy used for the clot removal device, and control the transmission of wireless energy E from the external energy source, based on the determined energy balance.
The functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
In yet an alternative embodiment, the external source of energy is controlled from outside the patient's body to release electromagnetic wireless energy, and released electromagnetic wireless energy is used for operating the blood clot removal device.
In another embodiment, the external source of energy is controlling from outside the patient's body to release non-magnetic wireless energy, and released non-magnetic wireless energy is used for operating the blood clot removal device.
Those skilled in the art will realize that the above various embodiments according to Figs. 13-29 could be combined in many different ways. For example, the electric switch 38 operated polarized energy could be incorporated in any of the embodiments of Figs. 15, 18-24, the hydraulic valve shifting device 54 could be incorporated in the embodiment of Fig. 16, and the gear box 74 could be incorporated in the embodiment of Fig. 15.
Wireless transfer of energy for operating the clot removal device has been described to enable non-invasive operation. It will be appreciated that the clot removal device can be operated with wire bound energy as well. On such example is shown in Fig. 29, wherein an external switch 84 is interconnected between the external energy source 34a and an operation device, such as an electric motor regulating the blood clot removal device 10, by means of power lines 86 and 88. An external control unit 34b controls the operation of the external switch to effect proper operation of the blood clot removal device 10.
Methods relating to the above described clot removal device and system will now be described in detail.
The clot removal device can be placed surgically in the patient via a laparoscopic abdominal approach. First, a tube is inserted into the abdomen of the patient's body and this tube is used to fill the patient's abdomen with gas, thereby expanding the patient's abdominal cavity. At least two laparoscopic trocars are then placed in the patient's body, where after a camera is inserted through one of the trocars into the patient's abdomen. At least one dissecting tool is inserted through a trocar and dissection is performed at two intended areas of the patient. A clot removal device is placed in any part of the vascular system in the abdomen.
Alternatively, the clot removal device can be placed in the patient's thorax. Thus, a tube is inserted into the thorax of the patient's body and this tube is used to fill the patient's thorax with gas, thereby expanding the patient's thoraxical cavity. At least two laparoscopic trocars are then placed in the patient's body, where after a camera is inserted through one of the trocars into the patient's thorax. At least one dissecting tool is inserted through a trocar and dissection is performed at two intended areas of the patient. A clot removal device is placed in any part of the vascular system in the thorax. An operation method for surgically placing a clot removal device starts with cutting the patient's skin and dissecting a placement area where to place the clot removal device inside the vascular system in the abdomen or thorax or retroperitoneal or subcutaneously or any limb of the patient. When a suitable place has been found, the clot removal device is placed in the placement area. The clot removal device can then be used postoperatively and non-invasively without penetrating the patent's skin for removing any blood clots from the vascular system to outside thereof, while using energy from an energy source without any penetration through the patient's skin to power the blood clot removal device.
A method for surgically treating a patient needing a blood clot removal device in the vascular system in the patient's abdomen preferably comprises cutting an opening in the patient's abdominal wall and then dissecting an area of the vascular system. A clot removal device is placed inside the vascular system, and the abdominal wall is sutured. In one embodiment, blood clots are moved away from the vascular system into an encapsulated closed bag in the patient's abdomen by means of the blood clot removal device. In another embodiment, blood clots are moved to the free abdomen.
Alternatively, a method for surgically treating a patient needing a blood clot removal device in the vascular system in the thorax comprises cutting an opening in the thorax wall and then dissecting the area of the vascular system. A clot removal device is placed inside the vascular system, and the thorax wall is sutured. A step of moving blood clots away from the vascular system can comprise moving blood clots either to a place that is free in the thorax, to a place that is free in the abdomen, or to a place that is encapsulated in a closed bag in the thorax.
In one embodiment, a method of using a system for removing blood clots comprises implanting an implantable source of energy, such as an implanted energy transforming device 30 and an accumulator 58, in the patient. An external source of energy, such as an external energy transmission device 34, is provided for providing energy to the system. This external source of energy is operated to release wireless energy, thereby non-invasively charging the implantable source of energy with the wireless energy, while controlling the implantable source of energy from outside the patient's body. In connection with operation of the clot removal device, energy is releasing. The wireless energy is preferably stored in the implantable source of energy.
During operation, the system for removing blood clots postoperatively and non- invasively regulates the clot removal device. Any blood clots, which have been accumulated in the vascular system of the patient's body, are moved away from the vascular system and are then placed outside the vascular system. This can be accomplished by an energy source, preferably repeatedly according to a preprogrammed time-schedule. The movement of any blood clots away from the vascular system and placement of the blood clots outside the vascular system are preferably repeated and at least partly controlled by an internal control unit getting input from a sensor sensing any physical parameter of the patient or any functional parameter of the device.
Preferred embodiments of a clot removal device, a system comprising a clot removal device, and a method according to the invention have been described. A person skilled in the art realizes that these could be varied within the scope of the appended claims.
The blood clot removal device has been described as an artificial device insertable in an artificial blood vessel of the patient. Alternatively, the blood clot removal device is an artificial device adapted to be placed between two open ends of a blood vessel of the patient or be placed inside or attached to a blood vessel via surgery.
The blood clot removal device has been described to be placed in the patient's abdomen or thorax. It could also be adapted to be placed in the patient's retroperitoneal region or cephalic or neck region or any limb of the patient.
The filter in the blood clot removal device may be exchanged and replaced with a new fresh filter when it becomes dirty. One embodiment of such a solution is described below in fig 30 and 31. There are obvious many different solutions to solve the same problems.
In Fig. 30a a cassette 127 for holding filters is shown. The cassette 27 comprises a revolving cylinder 129 having segments 130 each holding a filter. The cylinder 129 is tightly sealed between two supports 131 holding the cylinder 129 in place and providing a tight sealing. Preferable are the contacting surfaces made of ceramics to seal the surfaces with fine tolerances. The blood flow passageway of an implantable blood clot removal apparatus passes through the cassette 127. The cassette is driven by a motor 133 causing the cylinder 129 to revolve at suitable times. Preferable the filter is designed to move any collected blood clots out from the blood flow passageway together with revolving filter, when the filter leaves the blood flow passageway to be replaced with a new filter. The filter may be any kind of filter preferable with a space for the collected blood clots or blood clots adherent to the filter itself. Such a space to both the sealing plates when rotating, should preferable be larger before the filter seen in the blood flow passageway. The motor is powered by a power supply 123b. The power supply can be a power supply like the power supplies 123 or 123 a. In accordance with one embodiment the power supplies 123, 123 a and 123b is the one and same power supply. As with the power supplies 123 and 123a, the power supply 123b can receive wireless energy in a suitable form, including but not limited to inductive energy ultrasonic energy, light energy or any other form of wireless energy set out above. The energy is supplied by an external wireless energy transmitter 6 adapted to transmit energy through the skin 5 of a patient having the cassette 127 implanted. The power supply 132b can also comprise a control unit as described above for controlling the revolving cassette 127. The control unit can provide feedback to the outside and receive input data from an external transceiver 7 in a manner similar to the control unit used in conjunction with control of the pump.
In Fig. 30b the cassette 127 is shown from the side with the supports 131 and the revolving cylinder spaced apart is a disassembled view.
In Fig. 31a an alternative embodiment of the cassette 127 is shown. The view in Fig. 30a is similar to the view in Fig. 31a. In the embodiment in Fig. 31a a magazine 135 having a number of cylinders 129 stored therein is provided. Hereby a cylinder 129 can by replaced by shifting the cylinders in the magazine 135. In one embodiment the cylinders are shifted by pressurized air or a motor. The filter is then first replaced in the blood flow passageway and thereafter in a position outside the blood flow passageway replaced in the cassette. Such a replacement could preferable take place by having a number of filters in the cylinder 135 on one side of the cassette marked with 135 and moving the dirty filters out from the cassette into the cylinder on the other side of the cassette.
In an alternative embodiment the cylinder 135 is instead a cleaning device adapted to clean the filter at a position outside the blood flow passageway.
In Fig. 31b the cassette 127 is shown from the side with the supports 131 and the revolving cylinder spaced apart is a disassembled view.
Please note that any embodiment or part of embodiment or feature or method or associated system or part of system described herein may be combined in any combination.

Claims

1. A blood clot removal device for removing blood clots from the vascular system of a patient, the blood clot removal device being implantable in the patient's body and comprising:
a blood flow passageway,
a filter provided in the blood flow passageway for filtering blood clots, and
a cleaning device for cleaning the filter.
2. The device according to claim 1, wherein the cleaning device is adapted to move blood clots away from the blood flow passageway.
3. The device according to claim 2, wherein the cleaning device is adapted to move blood clots to a place free inside the patient' body.
4. The device according to claim 1 , comprising a collecting volume adapted to collect cleaned blood that has been cleaned from the filter.
5. The device according to claim 4, wherein the collecting volume comprises a bag.
6. The device according to claim 5, wherein the bag has a storage capacity of more than 100ml.
7. The device according to claim 1, wherein the cleaning device is adapted to slice, push or scratch away any clots from the filter.
8. The device according to claim 1 , wherein the cleaning device is adapted to suck away any clots from the filter.
9. The device according to claim 1 , wherein the cleaning device comprises a first piston.
10. The device according to claim 9, wherein an outer end portion of the first piston is provided with a first recess.
11. The device according to claim 9, wherein the first piston is provided with a plurality of channels for accommodating the filter in an extended position of said first piston.
12. The device according to claim 9, wherein the first piston is movable in a direction perpendicular to the direction of the blood flow passageway.
13. The device according to claim 12, wherein the first piston during movement is arranged to take away any clots from the filter.
14. The device according to claim 9, comprising a source of pressurized air controlling the movement of the first piston.
15. The device according to claim 9, comprising an electric motor controlling the movement of the first piston.
16. The device according to claim 9, comprising a solenoid controlling the movement of the first piston.
17. The device according to claim 9, comprising a second piston provided across the blood flow passageway from the first piston.
18. The device according to claim 17, wherein the second piston is movable in a direction essentially perpendicular to the direction of the blood flow passageway
19. The device according to claim 17, wherein the second piston is spring biased in the direction of the first piston.
20. The device according to claim 17, wherein an outer end portion of the second piston is provided with a second recess.
21. The device according to claim 17, comprising a third piston, which is movable in a direction perpendicular to both the direction of the blood flow passageway and the direction of movement of the first piston and of the second piston.
22. The device according to claim 1, wherein the filter is of biocompatible material.
23. The device according to claim 1 , wherein the filter comprises a plurality of strips.
24. The device according to claim 23, wherein the plurality of strips are equally spaced.
25. The device according to claim 23, wherein the plurality of strips has essentially rectangular cross-sectional shape.
26. The device according to claim 23, wherein the distance between two adjacent strips is less than 2 millimeters.
27. The device according to claim 26, wherein the distance between two adjacent strips is less than 1 millimeter.
28. The device according to claim 1 , wherein the blood flow passageway has an essentially square cross-sectional shape.
29. The device according to claim 1 , wherein the blood clot removal device is an artificial device insertable in or attached to a blood vessel of the patient.
30. The device according to claim 1 , wherein the blood clot removal device is adapted to be placed in a blood vessel via surgery.
31. The device according to claim 1 , wherein the blood clot removal device is adapted to be placed in the patient's abdomen.
32. The device according to claim 1 , wherein the blood clot removal device is adapted to be placed in the patient's thorax.
33. A blood clot removal system for removing blood clots of a patient, comprising a blood clot removal device according to claim 1 implanted in the patient.
34. The system according to claim 33, comprising a heart pump connected to the blood flow passageway.
35. The system according to claim 34, comprising a tube connecting the heart pump to the left ventricle of the patient's heart.
36. The system according to claim 34, comprising a tube for connecting the heart pump connected to the patient's aorta.
37. The system according to claim 33, comprising a switch, the switch being adapted to manually and non-invasively control a function of the blood clot removal device.
38. The system according to claim 37, wherein the switch is a subcutaneous switch.
39. The system according to claim 37, wherein the switch is an electric switch.
40. The system according to claim 33, comprising a hydraulic device for hydralically operating the blood clot removal device and having a hydraulic reservoir, wherein the blood clot removal device is adapted to non-invasively be regulated by manually pressing said hydraulic reservoir.
41. The system according to claim 33, comprising a wireless remote control for non-invasively regulating a function of the blood clot removal device.
42. The system according to claim 33, comprising a wireless energy transmitter for non-invasively energising the blood clot removal device.
43. The system according to claim 33, comprising an energy source adapted to power the blood clot removal device.
44. The system according to claim 43, wherein the energy source comprises an internal energy source.
45. The system according to claim 43, wherein the energy source is an internal energy source adapted to receive energy from an external energy source transmitting energy in a wireless mode.
46. The system according to claim 45, wherein the internal energy source is charged by the energy in the wireless mode.
47. The system according to claim 33, comprising a sensor sensing a parameter.
48. The system according to claim 47, wherein the sensor is a functional parameter sensor sensing a functional parameter of the blood clot removal system.
49. The system according to claim 47, wherein the functional parameter of the system is correlated to the transfer of energy for charging an internal energy source.
50. The system according to claim 3347, comprising a feedback device for sending information from inside the patient's body to the outside thereof to give feedback information related to a functional parameter of the blood clot removal device.
51. The system according to claim 47, comprising an internal control unit acting in response to a functional parameter sensed by the sensor.
52. The system according to claim 47, wherein the sensor is a physical parameter sensor sensing a physical parameter of the patient.
53. The system according to claim 52, wherein the physical parameter is one of body temperature, blood pressure, blood flow, heartbeats and breathing.
54. The system according to claim 52, wherein the physical parameter sensor is a pressure sensor.
55. The system according to claim 52, further comprising an internal control unit acting in response to the physical parameter sensed by the physical parameter sensor.
56. The system according to claim 33, comprising an operation device for operating the blood clot removal device.
57. The system according to claim 56, wherein the operation device comprises a motor or a pump.
58. The system according to claim 57, wherein the operation device comprises an electric motor.
59. The system according to claim 56, wherein the operation device is electrically powered.
60. The system according to claim 56, wherein the operation device comprises a hydraulic operation device.
61. The system according to claim 56, wherein the operation device comprises a pneumatic operation device.
62. A method of using the blood clot removal system according to claim 33, comprising the step of non-invasively regulating at least one function of the blood clot removal device from outside the patient's body.
63. The method according to claim 62, wherein the step of non-invasively regulating is performed by manually pressing a subcutaneous switch.
64. The method according to claim 62, wherein the system comprises a hydraulic reservoir connected to the blood clot removal device, and wherein the step of non- invasively regulating is performed by manually pressing said hydraulic reservoir.
65. The method according to claim 62, wherein the system comprises a wireless remote control, and wherein the step of non-invasively regulating is performed using said wireless remote control.
66. The method according to claim 62, wherein the system comprises a wireless energy transmitter, and wherein the step of non-invasively regulating is performed using said wireless energy transmitter.
67. The method according to claim 62, wherein an energy source is used for powering and adjusting a function of the blood clot removal device.
68. The method according to claim 67, wherein the energy source used comprises an internal energy source.
69. The method according to claim 68, wherein the internal energy source is associated with an external energy source adapted to transmit wireless energy.
70. The method according to claim 69, further comprising the step of transmitting energy from the external energy source to charge the internal energy source.
71. The method according to claim 70, further comprising the step of sending feedback information from inside the patient' s body to the outside thereof to give feed back related to a functional parameter of the device or physical parameter of the patient.
72. The method according to claim 71 , wherein the functional parameter of the device is correlated to the transfer of energy for charging the internal energy source.
73. A method of using the blood clot removal system according to claim 33, wherein wireless energy is transmitted for powering an operation device.
74. A method of using the blood clot removal system according to claim 33, comprising the steps of:
implanting an implantable source of energy in the patient,
- providing an external source of energy,
controlling the external source of energy to release wireless energy,
charging non-invasively the implantable source of energy with said wireless energy,
controlling the implantable source of energy from outside the patient's body, and releasing energy for use in connection with operation of the blood clot removal device.
75. The method according to claim 74, wherein the wireless energy is stored in the implantable source of energy.
76. The method of using the blood clot removal system according to claim 33, comprising the steps of:
providing an external source of energy outside the patient's body,
providing an operation device for operating the blood clot removal device,
controlling the external source of energy from outside the patient's body to release wireless energy, and
using said released wireless energy for operating the operation device.
77. The method according to claim 76, comprising the steps of transforming the wireless energy into electrical energy inside the patient's body using an implanted energy-transforming device and using said electrical energy when operating the blood clot removal device.
78. The method according to claim 77, further comprising directly using the electrical energy in connection with operation of the blood clot removal device, as a transforming device transforms the wireless energy into the electrical energy.
79. The method according to claim 76, further comprising the steps of:
- controlling the external source of energy from outside the patient's body to release non-magnetic wireless energy, and
using direct or indirect released non-magnetic wireless energy for operating the blood clot removal device.
80. The method according to claim 76, further comprising the steps of: controlling the external source of energy from outside the patient's body to release electromagnetic wireless energy, and
using direct or indirect released electromagnetic wireless energy for operating the blood clot removal device.
81. A method using an system according to claim 33, for postoperatively and non-invasively regulating the blood clot removal device, the method comprising the steps of:
moving any blood clots, which have been accumulated in the vascular system of the patient's body, away from the vascular system by means of the blood clot removal device, and
placing the blood clots outside the vascular system.
82. The method according to claim 81 , wherein the steps of moving any blood clots away from the vascular system and placing the blood clots outside the vascular system are powered by an energy source.
83. The method according to claim 81 , wherein the steps of moving any blood clots away from the vascular system and placing the blood clots outside the vascular system are repeated according to a pre-programmed time-schedule.
84 The method according to claim 81, wherein the steps of moving any blood clots away from the vascular system and placing the blood clots outside the vascular system are repeated and at least partly controlled by an internal control unit getting input from a sensor sensing any physical parameter of the patient or any functional parameter of the device.
85. A method for surgically placing a blood clot removal device in a patient via a laparoscopic abdominal approach, the method comprising the steps of:
- inserting a needle or a tube like instrument into the abdomen of the patient's body, using the needle or a tube like instrument to fill the patient's abdomen with gas thereby expanding the patient's abdominal cavity,
placing at least two laparoscopic trocars in the patient's body,
inserting a camera through one of the laparoscopic trocars into the patient's abdomen,
inserting at least one dissecting tool through one of said at least two laparoscopic trocars and dissecting an intended placement area of the patient,
placing a blood clot removal device in any part of the vascular system in the abdomen,
- moving blood clots away from vascular system post operatively, and
powering the device with a source of energy.
86. A method of surgically placing a blood clot removal device in a patient via a laparoscopic thoraxial approach, the method comprising the steps of:
inserting a needle or a tube like instrument into the thorax of the patient's body,
using the needle or a tube like instrument to fill the thorax with gas thereby expanding the thoraxical cavity,
placing at least two laparoscopic trocars in the patient's body,
inserting a camera through one of the laparoscopic trocars into the thorax,
- inserting at least one dissecting tool through one of said at least two laparoscopic trocars and dissecting an intended placement area of the patient,
placing a blood clot removal device in any part of the vascular system in the thorax,
moving blood clots away from vascular system post operatively, and powering the device with a source of energy,
87. The method according to claim 85 or 86, wherein the device is programmed from outside the body of the patient.
88. The method according to claim 85 or 86, wherein the step of moving blood clots away from vascular system post operatively to another a different part of the body comprises moving blood clots to a place that is free in the thorax.
89. The method according to claim 85 or 86, wherein the step of moving blood clots away from vascular system post operatively to another a different part of the body comprises moving blood clots to a place that is free in the abdomen.
90. The method according to claim 85 or 86, wherein the step of moving blood clots away from vascular system post operatively to another a different part of the body comprises moving blood clots to a place that is encapsulated in a closed bag in the thorax.
91. An operation method for surgically placing a blood clot removal device in a patient, the method comprising the steps of:
cutting the patient's skin,
dissecting a placement area where to place the blood clot removal device inside the vascular system in the abdomen or thorax or cephalic region retroperitoneal or subcutaneously or any limb of the patient,
- placing the blood clot removal device in the placement area,
removing, postoperatively and non-invasively, without penetrating the patent's skin, any blood clots from the vascular system to outside thereof, and
using energy from an energy source without any penetration through the patient's skin to power the blood clot removal device.
92. A method for surgically treating a patient needing a blood clot removal device in the vascular system in the patient's abdomen, the method comprising the steps of:
cutting an opening in the abdominal wall,
- dissecting an area of the vascular system,
placing the blood clot removal device inside the vascular system, and
suturing the abdominal wall.
93. A method for surgically treating a patient needing a blood clot removal device in the vascular system in the thorax, the method comprising the steps of:
- cutting an opening in the thorax wall,
dissecting an area of the vascular system,
placing the blood clot removal device inside the vascular system, and
suturing the thorax wall.
94. The method according to claim 92 or 93, comprising the step of moving blood clots away from the vascular system into an encapsulated closed bag in the patient's abdomen by means of the blood clot removal device.
95. The method according to claim 92 or 93, comprising the step of moving blood clots away from the vascular system into the free abdomen of the patient by means of the blood clot removal device.
96. The device according to claim 1 , wherein the blood clot removal device is an artificial device adapted to be placed between two open ends of a blood vessel of the patient.
97. The device according to claim 1, wherein the blood clot removal device is adapted to be placed attached to a blood vessel via surgery.
98. The device according to claim 1, wherein the blood clot removal device is adapted to be placed in any of the patient's limbs.
99. The device according to claim 1 , wherein the blood clot removal device is adapted to be placed in the patient's retroperitoneal region or cephalic or neck region of the patient.
100. The device according to claim 51 or 55, further comprising an operation device for operating the cleaning device, wherein the internal control unit controls the operation device to operate the cleaning device in response to the sensor sensing aparameter.
101. The device according to claim 1 , wherein the cleaning device is adapted to mechanically clean said filter.
PCT/SE2009/000040 2008-01-28 2009-01-28 Blood clot removal device, system, and method WO2009096855A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP21199129.4A EP3964243A1 (en) 2008-01-28 2009-01-28 Blood clot removal device, system, and method
US12/864,828 US10729894B2 (en) 2008-01-28 2009-01-28 Blood clot removal device, system, and method
EP09706196.4A EP2244662B1 (en) 2008-01-28 2009-01-28 Blood clot removal device and system
ES09706196T ES2901553T3 (en) 2008-01-28 2009-01-28 Blood clot removal device and system
US16/984,368 US11839848B2 (en) 2008-01-28 2020-08-04 Blood clot removal device, system, and method
US18/499,253 US20240058736A1 (en) 2008-01-28 2023-11-01 Blood clot removal device, system, and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US671108P 2008-01-28 2008-01-28
US61/006,711 2008-01-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/864,828 A-371-Of-International US10729894B2 (en) 2008-01-28 2009-01-28 Blood clot removal device, system, and method
US16/984,368 Continuation US11839848B2 (en) 2008-01-28 2020-08-04 Blood clot removal device, system, and method

Publications (1)

Publication Number Publication Date
WO2009096855A1 true WO2009096855A1 (en) 2009-08-06

Family

ID=40913032

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/SE2009/000036 WO2009096851A1 (en) 2008-01-28 2009-01-28 A drainage device comprising a filter cleaning device
PCT/SE2009/000040 WO2009096855A1 (en) 2008-01-28 2009-01-28 Blood clot removal device, system, and method
PCT/SE2009/000041 WO2009096856A1 (en) 2008-01-28 2009-01-28 A drainage device comprising an active filter
PCT/SE2009/000038 WO2009096853A1 (en) 2008-01-28 2009-01-28 Blood clot removal device, system, and method
PCT/SE2009/000037 WO2009096852A1 (en) 2008-01-28 2009-01-28 An implantable drainage device

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/SE2009/000036 WO2009096851A1 (en) 2008-01-28 2009-01-28 A drainage device comprising a filter cleaning device

Family Applications After (3)

Application Number Title Priority Date Filing Date
PCT/SE2009/000041 WO2009096856A1 (en) 2008-01-28 2009-01-28 A drainage device comprising an active filter
PCT/SE2009/000038 WO2009096853A1 (en) 2008-01-28 2009-01-28 Blood clot removal device, system, and method
PCT/SE2009/000037 WO2009096852A1 (en) 2008-01-28 2009-01-28 An implantable drainage device

Country Status (7)

Country Link
US (19) US8961448B2 (en)
EP (8) EP2244662B1 (en)
JP (1) JP5643113B2 (en)
AU (3) AU2009209515A1 (en)
CA (6) CA2749771C (en)
ES (2) ES2901553T3 (en)
WO (5) WO2009096851A1 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482145B1 (en) 2000-02-14 2002-11-19 Obtech Medical Ag Hydraulic anal incontinence treatment
US6464628B1 (en) 1999-08-12 2002-10-15 Obtech Medical Ag Mechanical anal incontinence
US6461292B1 (en) 1999-08-12 2002-10-08 Obtech Medical Ag Anal incontinence treatment with wireless energy supply
US6471635B1 (en) 2000-02-10 2002-10-29 Obtech Medical Ag Anal incontinence disease treatment with controlled wireless energy supply
CN1698552B (en) 2000-02-10 2010-05-12 厄罗洛吉卡股份公司 Controlled urinary incontinence treatment
MXPA02007649A (en) * 2000-02-10 2004-08-23 Potencia Medical Ag Urinary incontinence treatment with wireless energy supply.
BR0108223B1 (en) 2000-02-10 2009-08-11 mechanical apparatus for the treatment of impotence.
MX340163B (en) 2000-02-11 2016-06-29 Potentica Ag Impotence treatment apparatus with energy transforming means.
ATE380006T1 (en) 2000-02-11 2007-12-15 Potencia Medical Ag CONTROLLED IMPOTENCY TREATMENT
DE60111019T2 (en) 2000-02-14 2006-05-11 Potencia Medical Ag PROSTHESIS
US20030100929A1 (en) * 2000-02-14 2003-05-29 Peter Forsell Controlled penile prosthesis
BR0108307B1 (en) 2000-02-14 2009-12-01 Prosthesis apparatus for the treatment of male sexual impotence with wireless power supply device.
US8202248B2 (en) 2004-08-18 2012-06-19 Sequana Medical Ag Dialysis implant and methods of use
CA2650570C (en) * 2006-04-26 2017-06-06 Eastern Virginia Medical School Systems and methods for monitoring and controlling internal pressure of an eye or body part
GB0623395D0 (en) 2006-11-23 2007-01-03 Renishaw Plc Port
US20080207983A1 (en) 2007-02-22 2008-08-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Coded-sequence activation of surgical implants
US8961448B2 (en) * 2008-01-28 2015-02-24 Peter Forsell Implantable drainage device
EP3970664A1 (en) * 2008-01-28 2022-03-23 Implantica Patent Ltd. A fluid movement device
US9060771B2 (en) 2008-01-29 2015-06-23 Peter Forsell Method and instrument for treating obesity
WO2009140202A1 (en) * 2008-05-12 2009-11-19 Cardionephrx, Inc. Implantable fluid separation system
EP3689318A1 (en) 2008-10-10 2020-08-05 MedicalTree Patent Ltd. Heart help device and system
EP2349096B1 (en) 2008-10-10 2021-01-27 MedicalTree Patent Ltd. An improved artificial valve
US20110196484A1 (en) 2008-10-10 2011-08-11 Milux Holding Sa Heart help method
EP2349170B1 (en) 2008-10-10 2023-09-27 Implantica Patent Ltd. Apparatus for the treatment of female sexual dysfunction
EP3120896A1 (en) 2008-10-10 2017-01-25 Kirk Promotion LTD. A system, an apparatus, and a method for treating a sexual dysfunctional female patient
WO2010042032A1 (en) 2008-10-10 2010-04-15 Milux Holding S.A. Fastening means for implantable medcial control assembly
US9095436B2 (en) * 2009-04-14 2015-08-04 The Invention Science Fund I, Llc Adjustable orthopedic implant and method for treating an orthopedic condition in a subject
US9949812B2 (en) 2009-07-17 2018-04-24 Peter Forsell Vaginal operation method for the treatment of anal incontinence in women
US10952836B2 (en) 2009-07-17 2021-03-23 Peter Forsell Vaginal operation method for the treatment of urinary incontinence in women
GB201002370D0 (en) 2010-02-12 2010-03-31 Renishaw Ireland Ltd Percutaneous drug delivery apparatus
AU2012217696B2 (en) 2011-02-16 2015-11-12 Sequana Medical Nv Apparatus and methods for treating intracorporeal fluid accumulation
US8585635B2 (en) 2012-02-15 2013-11-19 Sequana Medical Ag Systems and methods for treating chronic liver failure based on peritoneal dialysis
GB201217606D0 (en) 2012-10-02 2012-11-14 Renishaw Plc Neurosurgical device and method
GB2510166B (en) 2013-01-28 2015-05-20 Cook Medical Technologies Llc Thrombus removal apparatus
US9126009B2 (en) 2013-03-12 2015-09-08 DePuy Synthes Products, Inc. System and method for determining position and pressure of an implantable shunt
WO2014150288A2 (en) 2013-03-15 2014-09-25 Insera Therapeutics, Inc. Vascular treatment devices and methods
DE102013106352A1 (en) * 2013-06-18 2014-12-18 Universität Zu Lübeck Cardiac support system and cardiac assistive procedure
WO2015200797A2 (en) * 2014-06-26 2015-12-30 The Trustees Of The University Of Pennsylvania Devices and methods for alleviating lymphatic system congestion
CA2906099C (en) 2014-09-30 2022-10-11 DePuy Synthes Products, Inc. Optical reading of an implantable valve
GB201417623D0 (en) 2014-10-06 2014-11-19 Ecole Polytech Medical fluid drainage system and method
CN108697423A (en) 2016-02-16 2018-10-23 伊瑟拉医疗公司 The part flow arrangement of suction unit and anchoring
US10716922B2 (en) 2016-08-26 2020-07-21 Sequana Medical Nv Implantable fluid management system having clog resistant catheters, and methods of using same
US10769244B2 (en) 2016-08-26 2020-09-08 Sequana Medical Nv Systems and methods for managing and analyzing data generated by an implantable device
US11253683B2 (en) * 2017-02-07 2022-02-22 ewimed Method and apparatus for treating ascites
WO2018170064A1 (en) 2017-03-15 2018-09-20 Merit Medical Systems, Inc. Transluminal stents and related methods
US10898631B2 (en) 2017-05-24 2021-01-26 Sequana Medical Nv Direct sodium removal method, solution and apparatus to reduce fluid overload in heart failure patients
US11559618B2 (en) 2017-05-24 2023-01-24 Sequana Medical Nv Formulations and methods for direct sodium removal in patients having severe renal dysfunction
US10687676B2 (en) * 2017-06-09 2020-06-23 Hamilton Sundstrand Corporation Microgravity urine collection and storage
EP3672677A1 (en) * 2017-08-25 2020-07-01 Strataca Systems Limited Indwelling pump for facilitating removal of urine from the urinary tract
US10696906B2 (en) 2017-09-29 2020-06-30 Marathon Petroleum Company Lp Tower bottoms coke catching device
KR102082503B1 (en) * 2017-10-31 2020-04-23 재단법인 아산사회복지재단 Drainage bag assembly
USD847864S1 (en) 2018-01-22 2019-05-07 Insera Therapeutics, Inc. Pump
US12000720B2 (en) 2018-09-10 2024-06-04 Marathon Petroleum Company Lp Product inventory monitoring
WO2020163380A1 (en) * 2019-02-05 2020-08-13 Merit Medical Systems, Inc. Vacuum assisted drainage reservoir and systems
US12031676B2 (en) 2019-03-25 2024-07-09 Marathon Petroleum Company Lp Insulation securement system and associated methods
US11975316B2 (en) 2019-05-09 2024-05-07 Marathon Petroleum Company Lp Methods and reforming systems for re-dispersing platinum on reforming catalyst
US11124714B2 (en) 2020-02-19 2021-09-21 Marathon Petroleum Company Lp Low sulfur fuel oil blends for stability enhancement and associated methods
KR20210127836A (en) * 2020-04-14 2021-10-25 삼성전자주식회사 Wireless power receiver and object stimulator
US20210361840A1 (en) * 2020-05-22 2021-11-25 Fenwal, Inc. Systems and methods for pumping saline through a sterilizing filter
CN111558246B (en) * 2020-05-28 2021-11-09 林汉斌 Refining frame with high-precision screening function for medical reagent processing
US11702600B2 (en) 2021-02-25 2023-07-18 Marathon Petroleum Company Lp Assemblies and methods for enhancing fluid catalytic cracking (FCC) processes during the FCC process using spectroscopic analyzers
US11898109B2 (en) 2021-02-25 2024-02-13 Marathon Petroleum Company Lp Assemblies and methods for enhancing control of hydrotreating and fluid catalytic cracking (FCC) processes using spectroscopic analyzers
US11905468B2 (en) 2021-02-25 2024-02-20 Marathon Petroleum Company Lp Assemblies and methods for enhancing control of fluid catalytic cracking (FCC) processes using spectroscopic analyzers
US20220268694A1 (en) 2021-02-25 2022-08-25 Marathon Petroleum Company Lp Methods and assemblies for determining and using standardized spectral responses for calibration of spectroscopic analyzers
US12037548B2 (en) 2021-10-10 2024-07-16 Marathon Petroleum Company Lp Methods and systems for enhancing processing of hydrocarbons in a fluid catalytic cracking unit using a renewable additive
US12018216B2 (en) 2021-10-10 2024-06-25 Marathon Petroleum Company Lp Methods and systems for enhancing processing of hydrocarbons in a fluid catalytic cracking unit using plastic
US11692141B2 (en) 2021-10-10 2023-07-04 Marathon Petroleum Company Lp Methods and systems for enhancing processing of hydrocarbons in a fluid catalytic cracking unit using a renewable additive
US11802257B2 (en) 2022-01-31 2023-10-31 Marathon Petroleum Company Lp Systems and methods for reducing rendered fats pour point
KR20230172060A (en) * 2022-06-14 2023-12-22 주식회사 유메드 Bladder continuous irrigation apparatus and method thereof
WO2024035645A1 (en) * 2022-08-08 2024-02-15 The Children's Hospital Of Philadelphia Expandable flow detection system for alleviating lymphatic system congestion
US20240189753A1 (en) * 2022-12-08 2024-06-13 Marathon Petroleum Company Lp Removable flue gas strainer and associated methods
CN116899338B (en) * 2023-05-31 2024-06-04 山东兆鼎瓷业有限公司 Flue gas treatment process and device for foamed ceramic production

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012108A1 (en) * 1999-08-12 2001-02-22 Potencia Medical Ag Medical implant apparatus with wireless energy transmission
WO2001045590A2 (en) * 1999-12-23 2001-06-28 Percusurge, Inc. Strut design for an occlusion device
US20020151922A1 (en) * 1998-05-13 2002-10-17 Michael Hogendijk Apparatus and methods for removing emboli during a surgical procedure
US20020165575A1 (en) * 2001-05-07 2002-11-07 Saleh Fathy M.A. Vascular filtration device
WO2005072169A2 (en) * 2004-01-20 2005-08-11 Massachusetts General Hospital Permanent thrombus filtering stent
US20050266042A1 (en) * 2004-05-27 2005-12-01 Medtronic Vascular, Inc. Methods and apparatus for treatment of aneurysmal tissue
US20060224177A1 (en) * 2005-04-01 2006-10-05 Stephanos Finitsis Thrombus removal system and process

Family Cites Families (866)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734649A (en) * 1956-02-14 Moistureproof vial closure
US2060913A (en) * 1934-07-07 1936-11-17 Western Electric Co Electrical conductor
US2279834A (en) * 1941-04-14 1942-04-14 Howard H Mcgee Valve
US2795641A (en) 1953-12-03 1957-06-11 Rowell Ross Fredrick Cord supporting coil
US2776055A (en) * 1954-08-13 1957-01-01 Medical Plastics Inc Blood filter with clot remover
US3017050A (en) * 1955-01-10 1962-01-16 Sr Courtland H Barr Blood sample collection apparatus
US2869543A (en) * 1957-08-23 1959-01-20 Iowa Cooperative Ass Injector
GB885674A (en) 1959-07-20 1961-12-28 Interscience Res Corp Improvements in or relating to mechanical hearts
US3127892A (en) * 1960-07-13 1964-04-07 Baxter Laboratories Inc Blood handling apparatus
US3209081A (en) 1961-10-02 1965-09-28 Behrman A Ducote Subcutaneously implanted electronic device
US3429314A (en) * 1965-07-26 1969-02-25 Kendall & Co Self-venting drainage system for body fluids
GB1194358A (en) 1967-11-22 1970-06-10 Dana Christopher Mears Fluid Flow Control Valve.
US3662758A (en) 1969-06-30 1972-05-16 Mentor Corp Stimulator apparatus for muscular organs with external transmitter and implantable receiver
US3598287A (en) 1969-08-01 1971-08-10 Heiko T De Man Liquid dispenser with level control
US3705575A (en) 1969-09-26 1972-12-12 Lynn Euryl Edwards Incontinence device for female use
US4141361A (en) * 1970-02-09 1979-02-27 Snyder Manufacturing Co., Incorporated Evacuator
US3731681A (en) 1970-05-18 1973-05-08 Univ Minnesota Implantable indusion pump
US3683926A (en) * 1970-07-09 1972-08-15 Dainippon Pharmaceutical Co Tube for connecting blood vessels
US3731679A (en) 1970-10-19 1973-05-08 Sherwood Medical Ind Inc Infusion system
US3683929A (en) * 1970-12-28 1972-08-15 Extracorporeal Med Spec Device for draining cerebrospinal fluid in cases of hydrocephalus
US3677242A (en) * 1971-01-11 1972-07-18 Baxter Laboratories Inc Air block prevention system
US3750194A (en) 1971-03-16 1973-08-07 Fairchild Industries Apparatus and method for reversibly closing a natural or implanted body passage
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US3692027A (en) 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US3783868A (en) * 1971-05-06 1974-01-08 Gulf Oil Corp Percutaneous implant
FR2138333B1 (en) 1971-05-24 1974-03-08 Rhone Poulenc Sa
US3917120A (en) * 1971-11-11 1975-11-04 Merck Patent Gmbh Single use container for liquid pharmaceutical compositions
US3817237A (en) 1972-08-24 1974-06-18 Medtronic Inc Regulatory apparatus
US3818511A (en) * 1972-11-17 1974-06-25 Medical Prod Corp Medical prosthesis for ducts or conduits
US3863622A (en) * 1973-01-09 1975-02-04 Robert Enno Buuck Incontinence system and methods of implanting and using same
US3875928A (en) * 1973-08-16 1975-04-08 Angelchik Jean P Method for maintaining the reduction of a sliding esophageal hiatal hernia
US3906674A (en) 1973-12-13 1975-09-23 Lowell D Stone Valve cleaner
US3900028A (en) * 1974-02-26 1975-08-19 American Hospital Supply Corp Injection site for sterile medical liquid container
US3998222A (en) * 1974-04-15 1976-12-21 Shihata Alfred A Subcutaneous arterio-venous shunt with valve
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US3923060A (en) * 1974-04-23 1975-12-02 Jr Everett H Ellinwood Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means
US3938520A (en) * 1974-06-10 1976-02-17 Abbott Laboratories Transfer unit having a dual channel transfer member
US3954102A (en) 1974-07-19 1976-05-04 American Medical Systems, Inc. Penile erection system and methods of implanting and using same
US4026305A (en) 1975-06-26 1977-05-31 Research Corporation Low current telemetry system for cardiac pacers
FR2347030A1 (en) 1975-08-04 1977-11-04 Guiset Jacques PROTHETIC BLADDER
US4033345A (en) * 1975-11-13 1977-07-05 Sorenson Research Co., Inc. Autologous transfusion filter system and method
US4009711A (en) * 1976-03-17 1977-03-01 Uson Aurelio C Penile prosthesis for the management of erectile impotence
US4206762A (en) * 1976-06-21 1980-06-10 Cosman Eric R Telemetric differential pressure sensing method
US4281667A (en) * 1976-06-21 1981-08-04 Cosman Eric R Single diaphragm telemetric differential pressure sensing system
US4056116A (en) * 1976-09-08 1977-11-01 Baxter Travenol Laboratories, Inc. Valve for interconnecting sterile containers and the like
US4152269A (en) * 1977-02-01 1979-05-01 Warner-Lambert Company Collection and separation device
US4230582A (en) * 1978-02-01 1980-10-28 Tuleja Anthony Z Drain traps with strainer means
US4190534A (en) * 1978-05-08 1980-02-26 Armco Steel Corporation Waste water filtration and sludge removal system
US4243306A (en) * 1978-05-30 1981-01-06 Bononi Walter H Pad device
US4246893A (en) * 1978-07-05 1981-01-27 Daniel Berson Inflatable gastric device for treating obesity
US4187893A (en) * 1978-07-19 1980-02-12 Abbott Laboratories Combined additive and administration port for a container
US4221219A (en) * 1978-07-31 1980-09-09 Metal Bellows Corporation Implantable infusion apparatus and method
SE412748B (en) 1978-09-15 1980-03-17 Engwall Sten sheet winches
US4201202A (en) 1978-09-25 1980-05-06 Medical Engineering Corp. Penile implant
US4235222A (en) * 1978-10-19 1980-11-25 Istrate Ionescu Heat-responsive alignment system and solar collection device
US4306705A (en) * 1979-01-22 1981-12-22 Svensson Jan A Slide valve and coupler assembly
US4217664A (en) * 1979-02-02 1980-08-19 Faso Joseph M Prosthesis and method for creating a stoma
US4265241A (en) 1979-02-28 1981-05-05 Andros Incorporated Implantable infusion device
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4304225A (en) 1979-04-30 1981-12-08 Lloyd And Associates Control system for body organs
US4271827A (en) 1979-09-13 1981-06-09 Angelchik Jean P Method for prevention of gastro esophageal reflux
US4274407A (en) 1979-11-13 1981-06-23 Med Pump, Inc. Fluid injection system
US4381775A (en) * 1980-02-05 1983-05-03 Takeda Chemical Industries, Ltd. Method for low pressure filtration of plasma from blood
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4426893A (en) * 1980-04-28 1984-01-24 Lear Siegler, Inc. High production serrator
US4318396A (en) * 1980-05-15 1982-03-09 Medical Engineering Corporation Penile prosthesis
DE3019996A1 (en) * 1980-05-24 1981-12-03 Institute für Textil- und Faserforschung Stuttgart, 7410 Reutlingen HOHLORGAN
JPS5935631B2 (en) * 1980-07-24 1984-08-29 テルモ株式会社 Body fluid “filtration” device
US4429693A (en) * 1980-09-16 1984-02-07 Blake L W Surgical fluid evacuator
US4342308A (en) 1980-10-02 1982-08-03 Medical Engineering Corporation Penile erectile system
US4400169A (en) 1980-10-27 1983-08-23 University Of Utah Research Foundation Subcutaneous peritoneal injection catheter
US4441215A (en) * 1980-11-17 1984-04-10 Kaster Robert L Vascular graft
US4424132A (en) * 1981-02-05 1984-01-03 Asahi Kasei Kogyo Kabushiki Kaisha Apparatus and method for separating blood components
EP0378251B1 (en) 1981-03-18 1994-06-01 Günther Walter Otto Bramm Magnetically suspended and rotated impellor pump apparatus
US4405053A (en) * 1981-04-27 1983-09-20 Abbott Laboratories Tamperproof closure system for plastic containers
US4447230A (en) * 1981-08-05 1984-05-08 Quest Medical, Inc. Intravenous administration set assembly
US4412530A (en) * 1981-09-21 1983-11-01 American Medical Systems, Inc. Dual-mode valve pressure regulating system
US4369771A (en) * 1981-09-24 1983-01-25 Medical Engineering Corporation Penile erectile system
JPS5859749U (en) * 1981-10-16 1983-04-22 オリンパス光学工業株式会社 container cap
US4399042A (en) * 1981-10-19 1983-08-16 The Dehydro Corporation Filter devices and methods
US4424807A (en) * 1981-10-20 1984-01-10 Evans Sr Alvin S Penile implant
US4503568A (en) * 1981-11-25 1985-03-12 New England Deaconess Hospital Small diameter vascular bypass and method
US4456175A (en) 1981-12-03 1984-06-26 Dnepropetrovsky Khimiko-Tekhnologichesky Institut Imeni F. E. Dzerzhinskogo Nozzle assembly for liquid spraying in coke oven ascension pipe
US4509947A (en) * 1982-08-02 1985-04-09 Medtronic, Inc. Self-cleaning drug delivery catheter and storage bladder
US4771772A (en) * 1982-08-09 1988-09-20 Medtronic, Inc. Robotic implantable medical device and/or component restoration system
EP0102548B1 (en) 1982-08-09 1988-11-02 Medtronic, Inc. Apparatus including an at least partially implantable device and method for maintaining such a device viable
US4628928A (en) 1982-08-09 1986-12-16 Medtronic, Inc. Robotic implantable medical device and/or component restoration system
US4599081A (en) 1982-09-30 1986-07-08 Cohen Fred M Artificial heart valve
US4542753A (en) * 1982-12-22 1985-09-24 Biosonics, Inc. Apparatus and method for stimulating penile erectile tissue
IL67773A (en) 1983-01-28 1985-02-28 Antebi E Tie for tying live tissue and an instrument for performing said tying operation
US4643718A (en) * 1983-02-22 1987-02-17 Applied Immunesciences, Inc. Therapeutic apheresis
US4505710A (en) * 1983-05-13 1985-03-19 Collins Earl R Implantable fluid dispensing system
US4491461A (en) * 1983-05-17 1985-01-01 Hoekstra Irenus A Method of desulfurization of flue gases
EP0126718A3 (en) * 1983-05-20 1985-10-23 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
DE3326250A1 (en) * 1983-07-21 1985-01-31 Lang Apparatebau GmbH, 8227 Siegsdorf BELLOW PUMP
US4595390A (en) * 1983-07-21 1986-06-17 Salomon Hakim Magnetically-adjustable cerebrospinal fluid shunt valve
US4714460A (en) * 1983-07-29 1987-12-22 Reynaldo Calderon Methods and systems for retrograde perfusion in the body for curing it of the disease or immume deficiency
ATE38938T1 (en) 1983-08-22 1988-12-15 Univ Utah Res Found PERITONEAL INJECTION CATHETER DEVICE.
US4584994A (en) 1983-09-30 1986-04-29 Charles Bamberger Electromagnetic implant
US4507114A (en) * 1983-10-21 1985-03-26 Baxter Travenol Laboratories, Inc. Multiple chamber container having leak detection compartment
US4550720A (en) * 1983-11-15 1985-11-05 Medical Engineering Corporation Capacitance device for medical implant
FR2555056B1 (en) * 1983-11-18 1986-02-28 Aerospatiale TOTAL HEART PROSTHESIS COMPRISING TWO DECOUPLED PUMPS ASSOCIATED IN A FUNCTIONALLY INDEPENDENT UNIT, AND ELECTRICALLY CONTROLLED VALVES FOR SUCH A PROSTHESIS
US4563175A (en) * 1983-12-19 1986-01-07 Lafond Margaret Multiple syringe pump
DE3408331C2 (en) * 1984-03-07 1986-06-12 Fresenius AG, 6380 Bad Homburg Pumping arrangement for medical purposes
DE3587885T2 (en) 1984-03-21 1994-11-03 Mclaughlin William F Filtration of a liquid suspension.
FR2561922B1 (en) * 1984-04-02 1987-04-30 Biomasys DEVICE FOR ATRAUMATIC ACCESS TO THE BLOOD CIRCUIT
US4619651A (en) * 1984-04-16 1986-10-28 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US4556050A (en) 1984-05-02 1985-12-03 Hodgson Darel E Artificial sphincter including a shape memory member
US4559930A (en) 1984-05-07 1985-12-24 Cobiski John F Thoracic bench
US4627832A (en) * 1984-05-08 1986-12-09 Cordis Corporation Three stage intracranial pressure relief valve having single-piece valve stem
US4668222A (en) * 1984-05-25 1987-05-26 Thermedics Inc. Percutaneous access device with removable tube
US4583523A (en) 1984-07-02 1986-04-22 Lloyd & Associates Implantable heart assist device and method of implanting same
EP0192712A1 (en) 1984-09-05 1986-09-03 Intra Optics Laboratories Pty. Limited Control of blood flow
US4568851A (en) * 1984-09-11 1986-02-04 Raychem Corporation Piezoelectric coaxial cable having a helical inner conductor
US4643716A (en) * 1984-09-26 1987-02-17 The Kendall Company Multi-size ureteral stent
US4598579A (en) * 1984-10-23 1986-07-08 Cordis Corporation Portable instrument to test pressure/flow of ventricular shunt valves
US4664100A (en) 1984-11-19 1987-05-12 Rudloff David A C Penile implant
US4756949A (en) 1984-11-29 1988-07-12 Kimberly-Clark Corporation Method for producing pad structures with viscoelastic cores and article so made
US4602621A (en) 1984-12-18 1986-07-29 Hakky Said I Manually actuated, self contained penile implant
JPS63501471A (en) 1984-12-27 1988-06-09 サントリー株式会社 Method for purifying interferon
DE3587090T2 (en) 1984-12-28 1993-06-03 Toshiba Kawasaki Kk REGULATED POWER SUPPLY.
US4610658A (en) * 1985-02-21 1986-09-09 Henry Buchwald Automated peritoneovenous shunt
EP0200286A3 (en) 1985-02-28 1987-01-14 Quotidian No. 100 Pty. Limited Control of blood flow
US4679560A (en) 1985-04-02 1987-07-14 Board Of Trustees Of The Leland Stanford Junior University Wide band inductive transdermal power and data link
US4592339A (en) 1985-06-12 1986-06-03 Mentor Corporation Gastric banding device
US4781677A (en) * 1985-07-17 1988-11-01 Wilcox Gilbert M Method of treatment utilizing a double balloon nasobiliary occlusion catheter
US4696288A (en) * 1985-08-14 1987-09-29 Kuzmak Lubomyr I Calibrating apparatus and method of using same for gastric banding surgery
US4698058A (en) * 1985-10-15 1987-10-06 Albert R. Greenfeld Ultrasonic self-cleaning catheter system for indwelling drains and medication supply
US4676772A (en) * 1985-12-23 1987-06-30 Cordis Corporation Adjustable implantable valve having non-invasive position indicator
US4681570A (en) * 1985-12-26 1987-07-21 Dalton Michael J Peritoneal catheter
US4728430A (en) * 1986-02-10 1988-03-01 Millipore Corporation Diafiltration method
US4828543A (en) * 1986-04-03 1989-05-09 Weiss Paul I Extracorporeal circulation apparatus
US5049129A (en) * 1986-05-29 1991-09-17 Zdeb Brian D Adapter for passive drug delivery system
US4871354A (en) * 1986-07-24 1989-10-03 The West Company Wet-dry bag with lyphozation vial
IE60235B1 (en) * 1986-09-18 1994-06-15 Kabi Pharmacia Ab "Connector and disposable assembly utilising said connector"
US4723538A (en) * 1986-10-16 1988-02-09 Stewart Edward T Penile constrictor ring
US4711231A (en) 1986-11-03 1987-12-08 Aaron N. Finegold Implantable prosthesis system
US4771780A (en) * 1987-01-15 1988-09-20 Siemens-Pacesetter, Inc. Rate-responsive pacemaker having digital motion sensor
GB8701731D0 (en) * 1987-01-27 1987-03-04 Patcentre Benelux Nv Sa Pumps
DE3705637A1 (en) * 1987-02-21 1988-09-29 Bissendorf Peptide Gmbh DEVICE FOR REMOVING LOCALLY APPLIED ACTIVE SUBSTANCES AGAINST SOLID TUMORS
US4925443A (en) 1987-02-27 1990-05-15 Heilman Marlin S Biocompatible ventricular assist and arrhythmia control device
US5098369A (en) * 1987-02-27 1992-03-24 Vascor, Inc. Biocompatible ventricular assist and arrhythmia control device including cardiac compression pad and compression assembly
FR2621248B1 (en) 1987-03-31 1989-08-18 Sroussi Donald DEVICE IMPLANTABLE IN THE ORGANISM FOR REPEATED INJECTION OF PRECISE DOSES OF LIQUID MEDICINAL SUBSTANCES
IT1204717B (en) * 1987-06-16 1989-03-10 Claber Spa VASCULAR ACCESS DEVICE, PARTICULARLY FOR BLOOD PURIFICATION TREATMENTS
US4829990A (en) 1987-06-25 1989-05-16 Thueroff Joachim Implantable hydraulic penile erector
NL8701644A (en) 1987-07-13 1989-02-01 Cordis Europ DEVICE FOR DOSING IN THE BODY OF A LIQUID MATERIAL.
US4846794A (en) 1987-08-13 1989-07-11 The Cleveland Clinic Foundation Coiled tubing for intravenous and intra-arterial applications
US5092849A (en) * 1987-08-25 1992-03-03 Shiley Infusaid, Inc. Implantable device
GB8722854D0 (en) * 1987-09-29 1987-11-04 Hardy S M Implantable artificial kidney
US4863453A (en) * 1987-12-22 1989-09-05 Sherwood Medical Company Sterile closure device
US5062835A (en) * 1988-01-15 1991-11-05 Maitz Carlos A Aspirator device for body fluids
US4981474A (en) * 1988-02-16 1991-01-01 Baxter Travenol Laboratories, Inc. Body fluid drainage device
US5009894A (en) * 1988-03-07 1991-04-23 Baker Cummins Pharmaceuticals, Inc. Arrangement for and method of administering a pharmaceutical preparation
US4883460A (en) * 1988-04-25 1989-11-28 Zanetti Paul H Technique for removing deposits from body vessels
US4942668A (en) 1988-05-11 1990-07-24 Zircon International, Inc. Digital inclinometer
US4979955A (en) 1988-06-06 1990-12-25 Smith Robert M Power assisted prosthetic heart valve
JP2675075B2 (en) * 1988-06-10 1997-11-12 株式会社新素材総合研究所 Container with contents
US4955857A (en) * 1988-07-18 1990-09-11 Shettigar Udipi R Multi-enzyme bioreactor therapy for cancer
US5152743A (en) * 1988-08-05 1992-10-06 Healthdyne, Inc. Apparatus and method for selective separation of blood cholesterol
US5151082A (en) * 1988-08-05 1992-09-29 Heathdyne, Inc. Apparatus and method for kidney dialysis using plasma in lieu of blood
US5224926A (en) 1988-08-05 1993-07-06 Healthdyne, Inc. Transvivo plasma extraction catheter device
US4950224A (en) * 1988-08-05 1990-08-21 Healthdyne, Inc. Apparatus and method for in vivo plasma separation
AU4191989A (en) * 1988-08-24 1990-03-23 Marvin J. Slepian Biodegradable polymeric endoluminal sealing
US5098377A (en) * 1988-09-06 1992-03-24 Baxter International Inc. Multimodal displacement pump and dissolution system for same
US4902279A (en) * 1988-10-05 1990-02-20 Autoject Systems Inc. Liquid medicament safety injector
US5681275A (en) * 1988-10-07 1997-10-28 Ahmed; Abdul Mateen Ophthalmological device with adaptable multiple distribution plates
US5123428A (en) 1988-10-11 1992-06-23 Schwarz Gerald R Laparoscopically implanting bladder control apparatus
US5012822A (en) 1988-10-11 1991-05-07 Schwarz Gerald R Method for controlling urinary incontinence
US5069662A (en) * 1988-10-21 1991-12-03 Delcath Systems, Inc. Cancer treatment
US4982731A (en) * 1988-10-26 1991-01-08 The Regents Of The University Of California Implantable system and method for augmenting penile erection
US5018646A (en) * 1988-11-23 1991-05-28 S. C. Johnson & Son, Inc. Squeezable fluid container
US5062416A (en) * 1988-12-01 1991-11-05 Stucks Albert A Penile erection system
US5011488A (en) * 1988-12-07 1991-04-30 Robert Ginsburg Thrombus extraction system
US5765706A (en) * 1989-02-03 1998-06-16 Senetics, Inc. Flush mounted indicator device
JPH02212768A (en) * 1989-02-13 1990-08-23 Terumo Corp Blood sampling tube
US5049146A (en) * 1989-05-31 1991-09-17 Baxter International, Inc. Blood/gas separator and flow system
WO1991000094A1 (en) 1989-06-28 1991-01-10 Finn Tranberg A new papaverine injection system
DE58903472D1 (en) 1989-08-09 1993-03-18 Siemens Ag IMPLANTABLE INJECTION BODY.
US4941461A (en) 1989-09-05 1990-07-17 Fischell Robert Electrically actuated inflatable penile erection device
US5042084A (en) 1989-09-07 1991-08-20 Cochlear Pty. Limited Three wire system for Cochlear implant processor
US5100564A (en) * 1990-11-06 1992-03-31 Pall Corporation Blood collection and processing system
US5876425A (en) * 1989-09-22 1999-03-02 Advanced Bionics Corporation Power control loop for implantable tissue stimulator
US5092839A (en) * 1989-09-29 1992-03-03 Kipperman Robert M Coronary thrombectomy
US5578267A (en) * 1992-05-11 1996-11-26 Minntech Corporation Cylindrical blood heater/oxygenator
US4958630A (en) * 1989-10-06 1990-09-25 Advanced Surgical Intervention, Inc. Method and apparatus for treating impotence
US5048511A (en) * 1989-10-06 1991-09-17 Advanced Surgical Intervention, Inc. Method and apparatus for treating impotence
US5057075A (en) 1989-12-13 1991-10-15 Moncrief Jack W Method for implanting a catheter
US4968296A (en) * 1989-12-20 1990-11-06 Robert Ritch Transscleral drainage implant device for the treatment of glaucoma
US4983177A (en) * 1990-01-03 1991-01-08 Wolf Gerald L Method and apparatus for reversibly occluding a biological tube
US5112202A (en) 1990-01-31 1992-05-12 Ntn Corporation Turbo pump with magnetically supported impeller
US5180362A (en) * 1990-04-03 1993-01-19 Worst J G F Gonio seton
US5147281A (en) * 1990-04-23 1992-09-15 Advanced Medical Systems, Inc. Biological fluid pumping means and method
US5156619A (en) * 1990-06-15 1992-10-20 Ehrenfeld William K Flanged end-to-side vascular graft
US5178603A (en) * 1990-07-24 1993-01-12 Baxter International, Inc. Blood extraction and reinfusion flow control system and method
US5074868A (en) 1990-08-03 1991-12-24 Inamed Development Company Reversible stoma-adjustable gastric band
US5006106A (en) 1990-10-09 1991-04-09 Angelchik Jean P Apparatus and method for laparoscopic implantation of anti-reflux prosthesis
US5316543A (en) 1990-11-27 1994-05-31 Cook Incorporated Medical apparatus and methods for treating sliding hiatal hernias
US5209347A (en) * 1990-12-05 1993-05-11 Clintec Nutrition Company Internal tear seal dual bag
US5167623A (en) * 1990-12-27 1992-12-01 The Kendall Company Multilumen catheter
US5484431A (en) * 1991-01-29 1996-01-16 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration System for creating at a site, remote from a sterile environment, a parenteral solution
US5314624A (en) * 1991-03-26 1994-05-24 Otsuka Pharmaceutical Factory, Inc. Process for filtering plasma and regenerating a secondary filter therefor
US5226429A (en) 1991-06-20 1993-07-13 Inamed Development Co. Laparoscopic gastric band and method
US5273526A (en) * 1991-06-21 1993-12-28 Lake Region Manufacturing Company, Inc. Vascular occulusion removal devices and method
US5358474A (en) * 1991-07-02 1994-10-25 Intermed, Inc. Subcutaneous drug delivery device
JPH07500023A (en) * 1991-07-04 1995-01-05 オーエン、アール・ロナルド tubular surgical implant
US5769812A (en) * 1991-07-16 1998-06-23 Heartport, Inc. System for cardiac procedures
US5250020A (en) * 1991-09-12 1993-10-05 Mentor Corporation Unitary inflatable penile prosthesis
EP0560984B1 (en) * 1991-09-27 1999-05-26 Terumo Kabushiki Kaisha Flexible member for medical use
US6471872B2 (en) * 1991-10-11 2002-10-29 Children's Hospital Medical Center Hemofiltration system and method based on monitored patient parameters
US5160338A (en) * 1991-11-13 1992-11-03 Inamed Development Co. Device for removing implantable articles
US5636643A (en) * 1991-11-14 1997-06-10 Wake Forest University Wound treatment employing reduced pressure
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
AU671971B2 (en) * 1991-11-29 1996-09-19 Chiron Corporation Anti-cancer immunotherapeutic vector constructs
US5403273A (en) * 1991-12-17 1995-04-04 Minnesota Mining And Manufacturing Company Blood reservoir
US5730883A (en) * 1991-12-23 1998-03-24 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process control parameter
CA2082467A1 (en) * 1992-01-30 1993-07-31 Wilfred Wilger Radially locking spray nozzle cap
JP3146465B2 (en) * 1992-03-13 2001-03-19 株式会社ニッショー Chemical injection device
FR2688693A1 (en) 1992-03-19 1993-09-24 Ferriere Xavier Artificial sphincter, especially urethral (urinary) sphincter
US5554013A (en) * 1992-05-01 1996-09-10 Mcgaw, Inc. Disposable cassette with negative head height fluid supply
JP2605345Y2 (en) * 1992-05-01 2000-07-10 株式会社大塚製薬工場 Drug container
US5281198A (en) * 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
FR2692777A1 (en) 1992-06-26 1993-12-31 Alfieri Patrick Remote control unit for implant esp. artificial sphincter in human body - uses oscillator, amplifier, and transmitting antenna to send energy to tuned receiving antenna on implant
JP3231086B2 (en) * 1992-06-30 2001-11-19 テルモ株式会社 Liquid separation device
WO1994003142A1 (en) 1992-07-30 1994-02-17 Temple University - Of The Commonwealth System Of Higher Education Direct manual cardiac compression device and method of use thereof
NZ244796A (en) * 1992-08-18 1995-05-26 Scherer Corp R P Capsule shell of soft gelatin contains a medicament and has a removable tab
US5397354A (en) * 1992-08-19 1995-03-14 Wilk; Peter J. Method and device for removing a toxic substance from blood
US5297536A (en) * 1992-08-25 1994-03-29 Wilk Peter J Method for use in intra-abdominal surgery
EP0591980B1 (en) * 1992-10-07 1999-05-06 Asahi Medical Co., Ltd. Leukocyte-removing filter device and system
US20020095164A1 (en) 1997-06-26 2002-07-18 Andreas Bernard H. Device and method for suturing tissue
US5447526A (en) * 1992-12-24 1995-09-05 Karsdon; Jeffrey Transcutaneous electric muscle/nerve controller/feedback unit
CA2153390A1 (en) * 1993-01-07 1994-07-21 Michael Richard Williams Low pressure contactor
US5439448A (en) * 1993-01-19 1995-08-08 Datascope Investment Corp. Bubble-free connector for liquid carrying tubing
US5910252A (en) * 1993-02-12 1999-06-08 Cobe Laboratories, Inc. Technique for extracorporeal treatment of blood
ES2125310T3 (en) 1993-02-18 1999-03-01 Lubomyr Ihor Kuzmak ADJUSTABLE GASTRIC BAND FOR LAPAROSCOPY.
US5449368A (en) * 1993-02-18 1995-09-12 Kuzmak; Lubomyr I. Laparoscopic adjustable gastric banding device and method for implantation and removal thereof
US5626843A (en) * 1993-02-26 1997-05-06 Advanced Biotherapy Concepts, Inc. Treatment of autoimmune diseases, including AIDS, by removel of interferons, TNFs and receptors therefor
US5888511A (en) * 1993-02-26 1999-03-30 Advanced Biotherapy Concepts, Inc. Treatment of autoimmune diseases, including AIDS
AU5637094A (en) * 1993-03-16 1994-09-22 Clintec Nutrition Company Peelable seal and container having same
DE4308586C1 (en) * 1993-03-18 1994-05-11 Fresenius Ag Haemodialysis appts. with balance chamber - involves inner volume of balance chamber being at most two thirds of that of dialysis fluid chamber
US5272664A (en) 1993-04-21 1993-12-21 Silicon Graphics, Inc. High memory capacity DRAM SIMM
DE69425966T2 (en) * 1993-04-27 2001-03-29 Haemonetics Corp., Braintree Apheresis device
US5632396A (en) * 1993-05-06 1997-05-27 Becton, Dickinson And Company Combination stopper-shield closure
US5385540A (en) * 1993-05-26 1995-01-31 Quest Medical, Inc. Cardioplegia delivery system
DE4317752C2 (en) 1993-05-27 1997-10-16 Peter Dr Feindt Device for supporting cardiac function
US5437605A (en) 1993-05-27 1995-08-01 Helmy; Ali M. Remote controllable penile prosthetic system
US5601604A (en) 1993-05-27 1997-02-11 Inamed Development Co. Universal gastric band
US5335773A (en) * 1993-07-02 1994-08-09 Habley Medical Technology Corporation Multi-pharmaceutical storage, mixing and dispensing vial
US5753227A (en) * 1993-07-23 1998-05-19 Strahilevitz; Meir Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases
US5445630A (en) * 1993-07-28 1995-08-29 Richmond; Frank M. Spike with luer fitting
US5405339A (en) * 1993-09-03 1995-04-11 Medtronic, Inc. Medical connector and method for connecting medical tubing
US5484612A (en) * 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin
US5505733A (en) 1993-10-22 1996-04-09 Justin; Daniel F. Intramedullary skeletal distractor and method
DE4338553A1 (en) * 1993-11-08 1995-05-18 Ferring Arzneimittel Gmbh Injection syringe for mixing and applying injection substances
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5443497A (en) * 1993-11-22 1995-08-22 The Johns Hopkins University Percutaneous prosthetic by-pass graft and method of use
AU1331595A (en) * 1993-11-30 1995-06-19 Medex, Inc. Anti-reflux valve with environmental barrier
CA2155735A1 (en) * 1993-12-22 1995-06-29 Richard C. Giesler Self-priming drip chamber with enhanced visibility
US5518504A (en) 1993-12-28 1996-05-21 American Medical Systems, Inc. Implantable sphincter system utilizing lifting means
US5415660A (en) 1994-01-07 1995-05-16 Regents Of The University Of Minnesota Implantable limb lengthening nail driven by a shape memory alloy
US5501703A (en) * 1994-01-24 1996-03-26 Medtronic, Inc. Multichannel apparatus for epidural spinal cord stimulator
US5504700A (en) 1994-02-22 1996-04-02 Sun Microsystems, Inc. Method and apparatus for high density sixteen and thirty-two megabyte single in-line memory module
DE4410876A1 (en) * 1994-03-29 1995-10-05 Fresenius Ag Medical multi-chamber bag and process for its manufacture
US5454840A (en) * 1994-04-05 1995-10-03 Krakovsky; Alexander A. Potency package
US6190691B1 (en) * 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
IL109499A (en) * 1994-05-02 1998-01-04 Univ Ramot Implant device for draining excess intraocular fluid
US5453079A (en) * 1994-06-15 1995-09-26 Schwaninger; Claude L. Blood flow valve for treatment of male sexual impotence
AU701572B2 (en) * 1994-07-11 1999-02-04 Dacomed Corporation Vessel occlusive prosthesis
US5509888A (en) 1994-07-26 1996-04-23 Conceptek Corporation Controller valve device and method
US5569187A (en) * 1994-08-16 1996-10-29 Texas Instruments Incorporated Method and apparatus for wireless chemical supplying
DK0776297T3 (en) * 1994-08-19 1999-05-10 Gore & Ass Ventilated bottle for freeze-drying and method for minimizing contamination of freeze-dried products
US5743874A (en) * 1994-08-29 1998-04-28 Fischell; Robert E. Integrated catheter for balloon angioplasty and stent delivery
US6071258A (en) * 1994-09-12 2000-06-06 Cobe Cardiovascular, Inc. Perfusion control assembly with improved component visibility and accessibility
US5540731A (en) 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for pressure detecting and treating obstructive airway disorders
US5571116A (en) * 1994-10-02 1996-11-05 United States Surgical Corporation Non-invasive treatment of gastroesophageal reflux disease
DE4435602C2 (en) 1994-10-05 1998-07-16 Gunter Preis Method and device for supplying implanted measuring, control and regulating systems with energy and for bidirectional data transfer
JP2911763B2 (en) * 1994-10-27 1999-06-23 三桜子 布川 Artificial blood vessel
CA2175720C (en) * 1996-05-03 2011-11-29 Ian M. Penn Bifurcated stent and method for the manufacture and delivery of same
FR2726768A1 (en) * 1994-11-14 1996-05-15 Debiotech Sa SYRINGE DEVICE ATTACHABLE TO A VIAL
US5601094A (en) * 1994-11-22 1997-02-11 Reiss; George R. Ophthalmic shunt
EP0714636B1 (en) * 1994-11-28 2003-04-16 The Ohio State University Interventional medicine apparatus
US5789147A (en) * 1994-12-05 1998-08-04 New York Blood Center, Inc. Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5725493A (en) * 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5433701A (en) * 1994-12-21 1995-07-18 Rubinstein; Mark H. Apparatus for reducing ocular pressure
US5591217A (en) 1995-01-04 1997-01-07 Plexus, Inc. Implantable stimulator with replenishable, high value capacitive power source and method therefor
DE19511998A1 (en) 1995-03-31 1996-10-02 Eska Medical Gmbh & Co Controller for discharge of urine from urethra
US5669883A (en) * 1995-04-12 1997-09-23 Symbiosis Corporation Veress needle and cannula assembly
JPH08336069A (en) 1995-04-13 1996-12-17 Eastman Kodak Co Electronic still camera
DE19517699C2 (en) * 1995-05-13 1999-11-04 Wilhelm Fleischmann Device for vacuum sealing a wound
AUPN295995A0 (en) * 1995-05-15 1995-06-08 Filtration Engineering Pty Ltd Apparatus & method for backwashing fluid filter systems
US5665065A (en) * 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input
US5518499A (en) 1995-06-06 1996-05-21 Aghr; Arif H. Intracavernous vasoactive pharmacological pump
US5702431A (en) 1995-06-07 1997-12-30 Sulzer Intermedics Inc. Enhanced transcutaneous recharging system for battery powered implantable medical device
US5775331A (en) 1995-06-07 1998-07-07 Uromed Corporation Apparatus and method for locating a nerve
US5662711A (en) * 1995-06-07 1997-09-02 Douglas; William Flow adjustable artery shunt
US6176240B1 (en) * 1995-06-07 2001-01-23 Conceptus, Inc. Contraceptive transcervical fallopian tube occlusion devices and their delivery
US5584808A (en) * 1995-06-20 1996-12-17 Healy; Patrick M. Valve mechanism
KR100373772B1 (en) * 1995-07-31 2003-09-13 심영택 Treatment apparatus for erectile disorder
IE77523B1 (en) * 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5771903A (en) 1995-09-22 1998-06-30 Kirk Promotions Limited Surgical method for reducing the food intake of a patient
US6102922A (en) 1995-09-22 2000-08-15 Kirk Promotions Limited Surgical method and device for reducing the food intake of patient
US5702019A (en) * 1995-09-27 1997-12-30 Becton Dickinson France S.A. Vial having resealable membrane assembly activated by a medical delivery device
US5704352A (en) * 1995-11-22 1998-01-06 Tremblay; Gerald F. Implantable passive bio-sensor
US5683357A (en) * 1995-12-01 1997-11-04 Magram; Gary External cerebrospinal fluid drain apparatus
US5578069A (en) * 1995-12-06 1996-11-26 Vnetritex, Inc. Electrode deployment mechanism and method using artificial muscle
ZA9610374B (en) * 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
US6428571B1 (en) * 1996-01-22 2002-08-06 Scimed Life Systems, Inc. Self-sealing PTFE vascular graft and manufacturing methods
AU2260397A (en) 1996-01-31 1997-08-22 Trustees Of The University Of Pennsylvania, The Remote control drug delivery device
US5925054A (en) * 1996-02-20 1999-07-20 Cardiothoracic Systems, Inc. Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis
US5807302A (en) * 1996-04-01 1998-09-15 Wandel; Thaddeus Treatment of glaucoma
US5846251A (en) * 1996-07-22 1998-12-08 Hart; Charles C. Access device with expandable containment member
SE9601348D0 (en) * 1996-04-10 1996-04-10 Pharmacia Ab Improved containers for parenteral fluids
US5707356A (en) * 1996-04-30 1998-01-13 Medtronic, Inc. Pressure relief valve
US5820579A (en) * 1996-04-30 1998-10-13 Medtronic, Inc. Method and apparatus for creating pulsatile flow in a cardiopulmonary bypass circuit
US5976109A (en) * 1996-04-30 1999-11-02 Medtronic, Inc. Apparatus for drug infusion implanted within a living body
JPH11509457A (en) 1996-05-05 1999-08-24 インフルーエンス メディカル テクノロジーズ リミテッド Implantable pumps and prostheses
US5928213A (en) * 1996-05-13 1999-07-27 B. Braun Medical, Inc. Flexible multiple compartment medical container with preferentially rupturable seals
US5800514A (en) * 1996-05-24 1998-09-01 Meadox Medicals, Inc. Shaped woven tubular soft-tissue prostheses and methods of manufacturing
US5980480A (en) * 1996-07-11 1999-11-09 Cs Fluids, Inc. Method and apparatus for treating adult-onset dementia of the alzheimer's type
US20030004495A1 (en) * 1996-07-11 2003-01-02 Eunoe, Inc. Apparatus and methods for volumetric CSF removal
US6689085B1 (en) * 1996-07-11 2004-02-10 Eunoe, Inc. Method and apparatus for treating adult-onset dementia of the Alzheimer's type
US5741326A (en) * 1996-07-15 1998-04-21 Cordis Corporation Low profile thermally set wrapped cover for a percutaneously deployed stent
US6835207B2 (en) * 1996-07-22 2004-12-28 Fred Zacouto Skeletal implant
FR2751867B1 (en) * 1996-08-05 1999-05-21 Leriche Rene Ass PROSTHESIS COLLERETTE
US5810760A (en) * 1996-08-08 1998-09-22 Thomas Jefferson University Cerebral edema solute catheter and method of draining cerebral edema
CN1140228C (en) 1996-08-09 2004-03-03 爱德华兹生命科学公司 Mechanical prosthetic valve, and methods of its construction and operation
US5814099A (en) 1996-08-12 1998-09-29 Bicer; Demetrio Central opening curved bileaflet heart valve prosthesis
US5851985A (en) * 1996-08-16 1998-12-22 Tepic; Slobodan Treatment of tumors by arginine deprivation
US5782383A (en) * 1996-09-04 1998-07-21 Rexan Closures Inc. Dispensing closure for sealed enteral fluid containers
CA2214754A1 (en) * 1996-09-09 1998-03-09 Masataka Narisada Method and apparatus for treating blood
US5902336A (en) * 1996-10-15 1999-05-11 Mirimedical, Inc. Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure
EP0846474B1 (en) * 1996-10-30 2003-08-27 Nihon Kohden Corporation Stimulating apparatus for preventing urinary incontinence
DE19646746C2 (en) * 1996-11-01 2003-09-18 Nanotron Technologies Gmbh Transmission method for wireless communication with an implanted medical device
US5845646A (en) 1996-11-05 1998-12-08 Lemelson; Jerome System and method for treating select tissue in a living being
US5749909A (en) 1996-11-07 1998-05-12 Sulzer Intermedics Inc. Transcutaneous energy coupling using piezoelectric device
US6019788A (en) * 1996-11-08 2000-02-01 Gore Enterprise Holdings, Inc. Vascular shunt graft and junction for same
CA2272348C (en) * 1996-11-22 2007-01-23 Therakos, Inc. Integrated cassette for controlling fluid having an integral filter
US5735809A (en) 1996-12-05 1998-04-07 Matria Healthcare, Inc. Fiber assembly for in vivo plasma separation
US5735887A (en) 1996-12-10 1998-04-07 Exonix Corporation Closed-loop, RF-coupled implanted medical device
JP3455040B2 (en) * 1996-12-16 2003-10-06 株式会社日立製作所 Source clock synchronous memory system and memory unit
GB9626960D0 (en) * 1996-12-27 1997-02-12 Glaxo Group Ltd Valve for aerosol container
JP2001509705A (en) * 1997-02-04 2001-07-24 フエール，アラン Screw-in tear tube cap
US6102884A (en) * 1997-02-07 2000-08-15 Squitieri; Rafael Squitieri hemodialysis and vascular access systems
US5903211A (en) * 1997-02-07 1999-05-11 Althin Medical, Inc. Medical treatment device with a user interface adapted for home or limited care environments
US5827286A (en) * 1997-02-14 1998-10-27 Incavo; Stephen J. Incrementally adjustable tibial osteotomy fixation device and method
WO1998037926A1 (en) * 1997-02-26 1998-09-03 Alfred E. Mann Foundation For Scientific Research Battery-powered patient implantable device
DE19708391C1 (en) * 1997-03-01 1998-10-22 Fresenius Medical Care De Gmbh Method and device for ultrafiltration in hemodialysis
US5800457A (en) * 1997-03-05 1998-09-01 Gelbfish; Gary A. Intravascular filter and associated methodology
US5824054A (en) * 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Coiled sheet graft stent and methods of making and use
US5814114A (en) * 1997-03-24 1998-09-29 Ltg Air Engineering, Inc. Airborne waste filter arrangement
DE19713747A1 (en) * 1997-04-04 1998-10-08 Rieter Ingolstadt Spinnerei Method and device for filtering fibers from an air stream
US6022333A (en) * 1997-05-01 2000-02-08 S.L.I.M. Tech, Ltd. Method and system for removing materials from lymphatic and other fluids
US5938669A (en) 1997-05-07 1999-08-17 Klasamed S.A. Adjustable gastric banding device for contracting a patient's stomach
US6059745A (en) * 1997-05-20 2000-05-09 Gelbfish; Gary A. Thrombectomy device and associated method
US6213979B1 (en) 1997-05-29 2001-04-10 Venetec International, Inc. Medical line anchoring system
US6061590A (en) * 1997-06-03 2000-05-09 Transonic Systems, Inc. Method and apparatus for predicting intradialytic morbid events through the monitoring of a central blood volume
US5954715A (en) * 1997-06-05 1999-09-21 Adiana, Inc. Method and apparatus for tubal occlusion
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
US5904698A (en) * 1997-06-10 1999-05-18 Applied Medical Resources Corporation Surgical shaving device for use within body conduits
US6332466B1 (en) 1997-07-08 2001-12-25 Inbae Yoon Ovarian capsules and methods of surgical contraception by ovarian encapsulation
US5919163A (en) * 1997-07-14 1999-07-06 Delcath Systems, Inc. Catheter with slidable balloon
ES2283020T3 (en) 1997-07-16 2007-10-16 Metacure Nv SMOOTH MUSCLE CONTROLLER.
CA2302466A1 (en) 1997-07-31 1999-02-11 Stanford Syncom Inc. Means and method for a synchronous network communications system
US6135945A (en) * 1997-08-04 2000-10-24 Sultan; Hashem Anti-incontinence device
US5873889A (en) * 1997-08-08 1999-02-23 Origin Medsystems, Inc. Tissue separation cannula with dissection probe and method
US6017493A (en) * 1997-09-26 2000-01-25 Baxter International Inc. Vacuum-assisted venous drainage reservoir for CPB systems
US5971967A (en) 1997-08-19 1999-10-26 Abbeymoor Medical, Inc. Urethral device with anchoring system
US5991665A (en) * 1997-09-18 1999-11-23 Sulzer Intermedics Inc. Self-cooling transcutaneous energy transfer system for battery powered implantable device
SE510286C2 (en) * 1997-09-22 1999-05-10 Gambro Med Tech Ab Method and Device for Monitoring Infusion Pump in a Hemo or Hemodia Filtration Machine
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US5980478A (en) * 1997-10-10 1999-11-09 Transvivo, Inc. Apparatus and method for the treatment of acute and chronic renal disease by continuous passive plasma ultrafiltration
US6409674B1 (en) 1998-09-24 2002-06-25 Data Sciences International, Inc. Implantable sensor with wireless communication
EP0909719B1 (en) * 1997-10-15 2002-07-24 Taisei Kako Co., Ltd., Closure for vial container
FR2769491B1 (en) 1997-10-15 2000-01-07 Patrick Sangouard ADJUSTABLE ARTIFICIAL SPHINCTER WITH MAGNETIC CONTROL
US6088608A (en) * 1997-10-20 2000-07-11 Alfred E. Mann Foundation Electrochemical sensor and integrity tests therefor
US5908435A (en) * 1997-10-23 1999-06-01 Samuels; Shaun L. W. Expandable lumen device and method of use
US6764481B1 (en) * 1997-10-27 2004-07-20 Otsuka Pharmaceutical Factory, Inc. Packaged ophthalmic perfusate and cleaning fluid bag
US5938584A (en) 1997-11-14 1999-08-17 Cybernetic Medical Systems Corporation Cavernous nerve stimulation device
US20040236877A1 (en) 1997-12-17 2004-11-25 Lee A. Burton Switch/network adapter port incorporating shared memory resources selectively accessible by a direct execution logic element and one or more dense logic devices in a fully buffered dual in-line memory module format (FB-DIMM)
US6432050B1 (en) * 1997-12-30 2002-08-13 Remon Medical Technologies Ltd. Implantable acoustic bio-sensing system and method
US6699231B1 (en) * 1997-12-31 2004-03-02 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US6074366A (en) * 1998-01-16 2000-06-13 Tandem Medical Inc. Medication delivery apparatus
JP3776227B2 (en) * 1998-01-16 2006-05-17 テルモ株式会社 Blood collection instrument
ES2255155T3 (en) 1998-02-05 2006-06-16 Biosense Webster, Inc. DEVICE FOR THE INTRACARDIAC ADMINISTRATION OF PHARMACOS.
US6007576A (en) * 1998-02-06 1999-12-28 Mcclellan; Scott B. End to side anastomic implant
US5995874A (en) * 1998-02-09 1999-11-30 Dew Engineering And Development Limited Transcutaneous energy transfer device
US7468060B2 (en) 1998-02-19 2008-12-23 Respiratory Diagnostic, Inc. Systems and methods for treating obesity and other gastrointestinal conditions
US6630215B1 (en) * 1998-03-09 2003-10-07 Denki Kagaku Kogyo Kabushiki Kaisha Medical Device
ES2149091B1 (en) * 1998-03-10 2001-05-16 Gil Vernet Vila Jose Maria DEVICE FOR FIXING AND ADJUSTABLE SUPPORT AT HEIGHT OF INTERNAL ANATOMICAL ORGANS.
US6638303B1 (en) * 1998-03-13 2003-10-28 Carbomedics, Inc. Heart valve prosthesis
WO1999047190A1 (en) * 1998-03-16 1999-09-23 Medtronic, Inc. Hemostatic system and components for extracorporeal circuit
US6319191B1 (en) 1998-03-26 2001-11-20 Precision Medical Devices, Inc. Implantable body fluid flow control device
US6095968A (en) 1998-04-10 2000-08-01 Cardio Technologies, Inc. Reinforcement device
US6209738B1 (en) * 1998-04-20 2001-04-03 Becton, Dickinson And Company Transfer set for vials and medical containers
US6099460A (en) 1998-04-28 2000-08-08 Denker; Stephen Electromagnetic heart assist technique and apparatus
US5910149A (en) 1998-04-29 1999-06-08 Kuzmak; Lubomyr I. Non-slipping gastric band
US6099495A (en) * 1998-04-30 2000-08-08 Medtronic, Inc. Implantable electrical transducer powered from capacitive storage energy source
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US6074341A (en) 1998-06-09 2000-06-13 Timm Medical Technologies, Inc. Vessel occlusive apparatus and method
US6361559B1 (en) * 1998-06-10 2002-03-26 Converge Medical, Inc. Thermal securing anastomosis systems
US6287516B1 (en) * 1998-07-10 2001-09-11 Immunocept, L.L.C. Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease
US6113574A (en) * 1998-07-27 2000-09-05 Spinello; Ronald P. Anesthetic injection apparatus and methods
US6113782A (en) * 1998-07-28 2000-09-05 Terumo Cardiovascular Systems Corporation Potting of tubular bundles in housing
US7935409B2 (en) 1998-08-06 2011-05-03 Kimberly-Clark Worldwide, Inc. Tissue sheets having improved properties
US6102887A (en) 1998-08-11 2000-08-15 Biocardia, Inc. Catheter drug delivery system and method for use
US6210347B1 (en) 1998-08-13 2001-04-03 Peter Forsell Remote control food intake restriction device
US6460543B1 (en) * 1998-08-13 2002-10-08 Obtech Medical Ag Non-injection port food intake restriction device
US6067991A (en) 1998-08-13 2000-05-30 Forsell; Peter Mechanical food intake restriction device
US6315767B1 (en) * 1998-08-19 2001-11-13 Gambro, Inc. Cell storage maintenance and monitoring system
JP2000070296A (en) * 1998-08-27 2000-03-07 M L C:Kk Intra-lacrimal duct intubation appliance
WO2000012152A1 (en) 1998-08-28 2000-03-09 Juan Hernandez Herrero Apparatus aiding physiologic systolic and diastolic dynamics of cardiac cavities
AU6384699A (en) * 1998-09-10 2000-04-03 Percardia, Inc. Tmr shunt
FR2783153B1 (en) 1998-09-14 2000-12-01 Jerome Dargent GASTRIC CONSTRICTION DEVICE
WO2000015140A1 (en) * 1998-09-15 2000-03-23 Infinite Biomedical Technologies, Incorporated Intraurethral continent prothesis
US7074216B2 (en) * 1998-09-15 2006-07-11 Baxter International Inc. Sliding reconstitution device for a diluent container
US6632189B1 (en) * 1998-09-18 2003-10-14 Edwards Lifesciences Corporation Support device for surgical systems
US6425867B1 (en) * 1998-09-18 2002-07-30 University Of Washington Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
US6167765B1 (en) * 1998-09-25 2001-01-02 The Regents Of The University Of Michigan System and method for determining the flow rate of blood in a vessel using doppler frequency signals
US6077215A (en) 1998-10-08 2000-06-20 Implex Gmbh Spezialhorgerate Method for coupling an electromechanical transducer of an implantable hearing aid or tinnitus masker to a middle ear ossicle
US6275737B1 (en) 1998-10-14 2001-08-14 Advanced Bionics Corporation Transcutaneous transmission pouch
US6134470A (en) * 1998-11-09 2000-10-17 Medtronic, Inc. Method and apparatus for treating a tachyarrhythmic patient
JP2000148656A (en) 1998-11-09 2000-05-30 Mitsubishi Electric Corp Memory system
US7189221B2 (en) * 1998-11-10 2007-03-13 Integra Life Sciences Corporation Methods for the treatment of a normal pressure hydrocephalus
US6645181B1 (en) * 1998-11-13 2003-11-11 Elan Pharma International Limited Drug delivery systems and methods
US6964643B2 (en) 1998-11-18 2005-11-15 Nugyn, Inc. Devices and methods for treatment of incontinence
AU760879B2 (en) 1998-11-25 2003-05-22 United States Surgical Corporation Biopsy system
US6097984A (en) 1998-11-25 2000-08-01 Medtronic, Inc. System and method of stimulation for treating gastro-esophageal reflux disease
US6486207B2 (en) 1998-12-10 2002-11-26 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6309384B1 (en) 1999-02-01 2001-10-30 Adiana, Inc. Method and apparatus for tubal occlusion
US6132415A (en) * 1999-02-09 2000-10-17 Vasca, Inc. Systems and methods for removing retained fluids and infusing therapeutic fluids
ES2150881B1 (en) 1999-02-11 2002-02-16 Univ Madrid Complutense EXTERNAL MAGNETIC OPERATING VALVE FOR AN INTRAURETRAL ARTIFICIAL URINARY SPINTER.
US6338144B2 (en) * 1999-02-19 2002-01-08 Sun Microsystems, Inc. Computer system providing low skew clock signals to a synchronous memory unit
US6162238A (en) 1999-02-24 2000-12-19 Aaron V. Kaplan Apparatus and methods for control of body lumens
US6254567B1 (en) * 1999-02-26 2001-07-03 Nxstage Medical, Inc. Flow-through peritoneal dialysis systems and methods with on-line dialysis solution regeneration
US6217552B1 (en) * 1999-03-01 2001-04-17 Coaxia, Inc. Medical device for selective intrathecal spinal cooling in aortic surgery and spinal trauma
US20040167613A1 (en) * 1999-03-11 2004-08-26 Ofer Yodfat Implantable stroke prevention device
US6142980A (en) * 1999-03-15 2000-11-07 3-T Medical Products, Llc Multi-function medical control valve assembly
ES2259286T3 (en) * 1999-03-15 2006-10-01 Implant Innovations, Inc. TROMBOCIT COLLECTION SYSTEM.
US6464655B1 (en) * 1999-03-17 2002-10-15 Environmental Robots, Inc. Electrically-controllable multi-fingered resilient heart compression devices
US6315752B1 (en) * 1999-03-26 2001-11-13 Scimed Life Systems, Inc. Implantable bypass device
GB2350794A (en) 1999-04-20 2000-12-13 Nagy Adly Habib Implantable pump
US8105258B2 (en) * 1999-04-26 2012-01-31 Baxter International Inc. Citrate anticoagulation system for extracorporeal blood treatments
AU767526B2 (en) * 1999-04-26 2003-11-13 Gmp Vision Solutions, Inc. Trabeculotomy device and method for treating glaucoma
US7395822B1 (en) 1999-04-30 2008-07-08 Uromedica, Inc. Method and apparatus for adjustable sling for treatment of urinary stress incontinence
ATE316391T1 (en) * 1999-04-30 2006-02-15 Childrens Hosp Medical Center HEMOFILTRATION SYSTEM
US6406605B1 (en) * 1999-06-01 2002-06-18 Ysi Incorporated Electroosmotic flow controlled microfluidic devices
US6183450B1 (en) * 1999-06-04 2001-02-06 William A Lois Catheter de-clogging device
AUPQ090499A0 (en) 1999-06-10 1999-07-01 Peters, William S Heart assist device and system
US6835200B2 (en) * 1999-06-22 2004-12-28 Ndo Surgical. Inc. Method and devices for tissue reconfiguration
US7744613B2 (en) 1999-06-25 2010-06-29 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US6197055B1 (en) * 1999-07-06 2001-03-06 Herbert L. Matthews Single chamber mechanical heart
US6839393B1 (en) * 1999-07-14 2005-01-04 Rambus Inc. Apparatus and method for controlling a master/slave system via master device synchronization
US6516227B1 (en) 1999-07-27 2003-02-04 Advanced Bionics Corporation Rechargeable spinal cord stimulator system
US6201001B1 (en) * 1999-08-02 2001-03-13 Abbott Laboratories Imidazole antiproliferative agents
AUPQ202699A0 (en) 1999-08-04 1999-08-26 University Of Melbourne, The Prosthetic device for incontinence
FR2797181B1 (en) 1999-08-05 2002-05-03 Richard Cancel REMOTE GASTRIC BAND DEVICE FOR FORMING A RESTRICTED STOMA OPENING IN THE ESTOMAC
US20040102804A1 (en) 1999-08-10 2004-05-27 Chin Albert K. Apparatus and methods for endoscopic surgical procedures
US6454699B1 (en) * 2000-02-11 2002-09-24 Obtech Medical Ag Food intake restriction with controlled wireless energy supply
US6453907B1 (en) * 1999-08-12 2002-09-24 Obtech Medical Ag Food intake restriction with energy transfer device
US6454698B1 (en) * 1999-08-12 2002-09-24 Obtech Medical Ag Anal incontinence treatment with energy transfer device
US6454701B1 (en) * 1999-08-12 2002-09-24 Obtech Medical Ag Heartburn and reflux disease treatment apparatus with energy transfer device
US6471635B1 (en) * 2000-02-10 2002-10-29 Obtech Medical Ag Anal incontinence disease treatment with controlled wireless energy supply
NZ516962A (en) 1999-08-12 2003-09-26 Potencia Medical Ag Stoma opening forming apparatus
US6461292B1 (en) * 1999-08-12 2002-10-08 Obtech Medical Ag Anal incontinence treatment with wireless energy supply
US6464628B1 (en) * 1999-08-12 2002-10-15 Obtech Medical Ag Mechanical anal incontinence
US6482145B1 (en) 2000-02-14 2002-11-19 Obtech Medical Ag Hydraulic anal incontinence treatment
US6533733B1 (en) * 1999-09-24 2003-03-18 Ut-Battelle, Llc Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring
FR2799362B1 (en) * 1999-10-11 2002-01-18 Perouse Implant Lab COLLAR PROSTHESIS
US6319279B1 (en) * 1999-10-15 2001-11-20 Edwards Lifesciences Corp. Laminated self-sealing vascular access graft
US6730054B2 (en) * 1999-10-16 2004-05-04 Baxter International Inc. Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit
US6321282B1 (en) 1999-10-19 2001-11-20 Rambus Inc. Apparatus and method for topography dependent signaling
US6322546B1 (en) * 1999-10-28 2001-11-27 Jostra Bentley Inc. Fluid control conduit
US6579235B1 (en) * 1999-11-01 2003-06-17 The Johns Hopkins University Method for monitoring intraocular pressure using a passive intraocular pressure sensor and patient worn monitoring recorder
US6116193A (en) * 1999-11-05 2000-09-12 Goeckner; Troy C. Sow breeding saddle
US6500809B1 (en) * 1999-11-12 2002-12-31 Neuron Therapeutics, Inc. Hyperoncotic artificial cerebrospinal fluid and method of treating neural tissue edema therewith
DE19955578C1 (en) * 1999-11-18 2001-09-06 Fresenius Medical Care De Gmbh Multi-chamber container, with glucose concentrate compartment and hydrochloric acid concentrate compartment
US6379708B1 (en) * 1999-11-20 2002-04-30 Cytologic, Llc Method for enhancing immune responses in mammals
FR2802798B1 (en) 1999-12-22 2002-02-01 Promedon S A PAD STRAP FOR THE TREATMENT OF URINARY INCONTINENCE
US6502161B1 (en) 2000-01-05 2002-12-31 Rambus Inc. Memory system including a point-to-point linked memory subsystem
US7131959B2 (en) * 2003-01-23 2006-11-07 Integrated Vascular Interventional Technologies, L.C., (“IVIT LC”) Apparatus and methods for occluding an access tube anastomosed to sidewall of an anatomical vessel
US6764472B1 (en) * 2000-01-11 2004-07-20 Bard Access Systems, Inc. Implantable refillable infusion device
US6447443B1 (en) 2001-01-13 2002-09-10 Medtronic, Inc. Method for organ positioning and stabilization
US6694191B2 (en) 2000-01-21 2004-02-17 Medtronic Minimed, Inc. Ambulatory medical apparatus and method having telemetry modifiable control software
US6600953B2 (en) 2000-12-11 2003-07-29 Impulse Dynamics N.V. Acute and chronic electrical signal therapy for obesity
WO2001054615A2 (en) 2000-01-25 2001-08-02 Harridan Medical Device for preventing fecal incontinence
US6311905B1 (en) * 2000-02-07 2001-11-06 Franklin Miller, Inc. Screen cleaning and comminuting system
US20030050591A1 (en) * 2000-02-08 2003-03-13 Patrick Mchale Anthony Loading system and method for using the same
US6454700B1 (en) * 2000-02-09 2002-09-24 Obtech Medical Ag Heartburn and reflux disease treatment apparatus with wireless energy supply
CN1698552B (en) * 2000-02-10 2010-05-12 厄罗洛吉卡股份公司 Controlled urinary incontinence treatment
BR0108223B1 (en) * 2000-02-10 2009-08-11 mechanical apparatus for the treatment of impotence.
EP1598030B1 (en) 2000-02-10 2008-06-25 Potencia Medical AG Controlled urinary incontinence treatment
US6470892B1 (en) * 2000-02-10 2002-10-29 Obtech Medical Ag Mechanical heartburn and reflux treatment
US6463935B1 (en) * 2000-02-10 2002-10-15 Obtech Medical Ag Controlled heartburn and reflux disease treatment
MXPA02007649A (en) * 2000-02-10 2004-08-23 Potencia Medical Ag Urinary incontinence treatment with wireless energy supply.
EP1582175B1 (en) 2000-02-10 2008-08-06 Potencia Medical AG Mechanical impotence treatment apparatus
CA2398326C (en) 2000-02-10 2008-12-16 Surgical Development Ag Anal incontinence treatment apparatus with wireless energy supply
MX340163B (en) * 2000-02-11 2016-06-29 Potentica Ag Impotence treatment apparatus with energy transforming means.
US6450946B1 (en) * 2000-02-11 2002-09-17 Obtech Medical Ag Food intake restriction with wireless energy transfer
EP1792583A1 (en) 2000-02-11 2007-06-06 Potencia Medical AG Urinary incontinence treatment apparatus
WO2001045486A2 (en) * 2000-02-11 2001-06-28 Potencia Medical Ag Urinary incontinence treatment apparatus
ATE380006T1 (en) 2000-02-11 2007-12-15 Potencia Medical Ag CONTROLLED IMPOTENCY TREATMENT
US6604561B2 (en) * 2000-02-11 2003-08-12 Medical Instill Technologies, Inc. Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial
MXPA02007704A (en) 2000-02-11 2002-10-17 Obtech Medical Ag Food intake restriction apparatus with controlled wireless energy supply.
EP1255511B1 (en) * 2000-02-14 2006-01-11 Potencia Medical AG Male sexual impotence treatment apparatus
DE60110392T2 (en) * 2000-02-14 2006-03-09 Potencia Medical Ag HYDRAULIC DEVICE FOR THE TREATMENT OF HARNINE CONTINENCE
US20030100929A1 (en) * 2000-02-14 2003-05-29 Peter Forsell Controlled penile prosthesis
DE60111019T2 (en) * 2000-02-14 2006-05-11 Potencia Medical Ag PROSTHESIS
JP2001218840A (en) * 2000-02-14 2001-08-14 Kanegafuchi Chem Ind Co Ltd Adsorbent for transforming growth factor. beta, adsorbing/removing method, and adsorber
ES2252191T3 (en) 2000-02-14 2006-05-16 Potencia Medical Ag PROTESIS FOR CONTROLLED PENIS.
US6475136B1 (en) 2000-02-14 2002-11-05 Obtech Medical Ag Hydraulic heartburn and reflux treatment
BR0108307B1 (en) * 2000-02-14 2009-12-01 Prosthesis apparatus for the treatment of male sexual impotence with wireless power supply device.
US6471688B1 (en) * 2000-02-15 2002-10-29 Microsolutions, Inc. Osmotic pump drug delivery systems and methods
US6400988B1 (en) 2000-02-18 2002-06-04 Pacesetter, Inc. Implantable cardiac device having precision RRT indication
CA2672076A1 (en) * 2000-03-01 2001-09-07 Caridianbct, Inc. Extracorporeal blood processing information management system
IL138632A (en) 2000-09-21 2008-06-05 Minelu Zonnenschein Multiple view endoscopes
MXPA02008996A (en) 2000-03-16 2004-10-15 Medigus Ltd Fundoplication apparatus and method.
US7713227B2 (en) * 2000-03-20 2010-05-11 Michael Wholey Method and apparatus for medical device for aspiration of thromboemobolic debris
US6215727B1 (en) 2000-04-04 2001-04-10 Intel Corporation Method and apparatus for utilizing parallel memory in a serial memory system
US6650943B1 (en) 2000-04-07 2003-11-18 Advanced Bionics Corporation Fully implantable neurostimulator for cavernous nerve stimulation as a therapy for erectile dysfunction and other sexual dysfunction
US20020143284A1 (en) * 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US6638239B1 (en) * 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7867186B2 (en) * 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
JP2001299875A (en) * 2000-04-24 2001-10-30 Nipro Corp Liquid housing bag
US6456883B1 (en) * 2000-04-26 2002-09-24 Medtronic, Inc. Apparatus and method for allowing immediate retrieval for information and identification from an implantable medical device having a depleted power source
US6447500B1 (en) * 2000-04-28 2002-09-10 Medtronic, Inc. Brain fluid ion concentration modification for treating neurological disorders
US7167756B1 (en) * 2000-04-28 2007-01-23 Medtronic, Inc. Battery recharge management for an implantable medical device
US6773428B2 (en) * 2000-05-12 2004-08-10 Stephen M. Zappala Implantable delivery system and method for the pharmacologic management of erectile dysfunction
JP3757757B2 (en) * 2000-05-18 2006-03-22 株式会社日立製作所 Read priority memory system
US6459917B1 (en) * 2000-05-22 2002-10-01 Ashok Gowda Apparatus for access to interstitial fluid, blood, or blood plasma components
JP3926968B2 (en) * 2000-05-29 2007-06-06 明夫 川村 Non-puncture blood access for hemodialysis
US6533759B1 (en) * 2000-06-01 2003-03-18 Robert Watson Flash chamber with a self closing valve for use with a catheter
US7530964B2 (en) 2000-06-30 2009-05-12 Elan Pharma International Limited Needle device and method thereof
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US6746461B2 (en) 2000-08-15 2004-06-08 William R. Fry Low-profile, shape-memory surgical occluder
US6862479B1 (en) * 2000-08-30 2005-03-01 Advanced Bionics Corporation Spinal cord stimulation as a therapy for sexual dysfunction
US6592515B2 (en) * 2000-09-07 2003-07-15 Ams Research Corporation Implantable article and method
US6730056B1 (en) * 2000-09-21 2004-05-04 Motorola, Inc. Eye implant for treating glaucoma and method for manufacturing same
WO2002028454A2 (en) 2000-10-04 2002-04-11 Insulet Corporation Data collection assembly for patient infusion system
US6582463B1 (en) * 2000-10-11 2003-06-24 Heartstent Corporation Autoanastomosis
US6616624B1 (en) * 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US6585675B1 (en) * 2000-11-02 2003-07-01 Chf Solutions, Inc. Method and apparatus for blood withdrawal and infusion using a pressure controller
US6591137B1 (en) 2000-11-09 2003-07-08 Neuropace, Inc. Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders
DK1702635T3 (en) 2000-11-09 2008-05-26 Insulet Corp Transcutaneous delivery means
ATE353682T1 (en) * 2000-11-30 2007-03-15 Terumo Corp BLOOD RESERVOIR
FR2817754B1 (en) * 2000-12-08 2003-09-12 Hospal Internat Marketing Man DEVICE FOR PRESSURE MEASUREMENT COMPRISING A MEMBRANE MOLDED IN A CASSETTE
TW458771B (en) 2000-12-13 2001-10-11 Jiang R Chung Structure of blood-propelling cavity of artificial left ventricle
JP4276834B2 (en) * 2000-12-27 2009-06-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Biological information and blood processing apparatus information management system
US6517526B1 (en) * 2000-12-29 2003-02-11 Yehuda Tamari Container for lyophilizing biological products
US6659973B2 (en) 2001-01-04 2003-12-09 Transvivo, Inc. Apparatus and method for in-vivo plasmapheresis using periodic backflush
US8323228B2 (en) * 2007-04-12 2012-12-04 Rex Medical L.P. Dialysis catheter
US20020095210A1 (en) * 2001-01-16 2002-07-18 Finnegan Michael T. Heart pump graft connector and system
US6612977B2 (en) 2001-01-23 2003-09-02 American Medical Systems Inc. Sling delivery system and method of use
US6730267B2 (en) * 2001-02-09 2004-05-04 Cardiovention, Inc. Integrated blood handling system having active gas removal system and methods of use
US20030060695A1 (en) * 2001-03-07 2003-03-27 Connelly Patrick R. Implantable artificial organ devices
EP1977724A1 (en) * 2001-04-07 2008-10-08 Glaukos Corporation System for treating ocular disorders
US7488303B1 (en) * 2002-09-21 2009-02-10 Glaukos Corporation Ocular implant with anchor and multiple openings
US20020197252A1 (en) * 2001-04-10 2002-12-26 Renal Tech International Selective adsorption devices and systems
US6605108B2 (en) * 2001-04-13 2003-08-12 Eagle Vision, Inc. Monocanalicular stent
US7330753B2 (en) * 2001-04-18 2008-02-12 Metacure N.V. Analysis of eating habits
US6516282B2 (en) * 2001-04-19 2003-02-04 Ge Medical Systems Global Technology Company Predictive thermal control used with a vacuum enclosed coil assembly of a magnetic resonance imaging device
US8091556B2 (en) * 2001-04-20 2012-01-10 V-Wave Ltd. Methods and apparatus for reducing localized circulatory system pressure
US20050240229A1 (en) * 2001-04-26 2005-10-27 Whitehurst Tood K Methods and systems for stimulation as a therapy for erectile dysfunction
US7756582B2 (en) 2001-05-01 2010-07-13 Intrapace, Inc. Gastric stimulation anchor and method
US6535764B2 (en) * 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
US7020531B1 (en) 2001-05-01 2006-03-28 Intrapace, Inc. Gastric device and suction assisted method for implanting a device on a stomach wall
US6607501B2 (en) * 2001-05-14 2003-08-19 Reynolds G. Gorsuch Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications
DE10123769C1 (en) * 2001-05-16 2002-12-12 Infineon Technologies Ag Method for adapting different signal propagation times between a controller and at least two processing units and a computer system
US6678561B2 (en) * 2001-05-23 2004-01-13 Surgical Development Ag Heartburn and reflux disease treatment apparatus
SE0102313D0 (en) * 2001-06-28 2001-06-28 Obtech Medical Ag Intestine dysfunction treatment apparatus
US6551235B2 (en) * 2001-06-28 2003-04-22 Potencia Medical Ag Implantable pump
SE0102312D0 (en) 2001-06-28 2001-06-28 Obtech Medical Ag Urinary dysfunction treatment apparatus
TWI244919B (en) * 2001-07-06 2005-12-11 Showa Denko Plastic Product Co Multiple connected medical container and production method thereof
US6796963B2 (en) * 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Flexible tissue injection catheters with controlled depth penetration
KR100407467B1 (en) 2001-07-12 2003-11-28 최수봉 Insulin pump operated by remote-controller
US6901295B2 (en) * 2001-07-14 2005-05-31 Virender K. Sharma Method and apparatus for electrical stimulation of the lower esophageal sphincter
US6627206B2 (en) * 2001-07-25 2003-09-30 Greg A. Lloyd Method and apparatus for treating obesity and for delivering time-released medicaments
JP4883852B2 (en) * 2001-07-30 2012-02-22 日東電工株式会社 Heat peeling method of chip cut piece from heat release type adhesive sheet
US20030078487A1 (en) * 2001-08-09 2003-04-24 Jeffries Robert E. Ocular pressure measuring device
US6928338B1 (en) 2001-08-10 2005-08-09 Medtronic, Inc. Decision information system for drug delivery devices
US20030208247A1 (en) 2001-09-28 2003-11-06 Michele Spinelli Implantable stimulation lead with tissue in-growth anchor
FR2830455B1 (en) 2001-10-09 2004-06-25 Saphir Medical CATHETER WITH RETRACTABLE PERFORATING OR STITCHING TOOL
JP2003116982A (en) * 2001-10-10 2003-04-22 Medicos Hirata:Kk System for drainage of gallbladder through duodenum under endoscope
DE60239282D1 (en) 2001-10-17 2011-04-07 Transvivo Inc Plasmapheresis filter device and device for therapeutic apheresis
US6849183B2 (en) * 2002-08-13 2005-02-01 Transvivo, Inc. Method and apparatus for therapeutic apheresis
US7727219B2 (en) * 2001-10-22 2010-06-01 Vita 34 Ag Sterile system and methods for collecting, transporting, storing and cyropreserving body fluids
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20040045924A1 (en) * 2001-11-09 2004-03-11 Masanori Naritomi Leak stop plug against needle piercing and method of manufacturing the leak stop plug
US7309323B2 (en) * 2001-11-16 2007-12-18 National Quality Care, Inc. Wearable continuous renal replacement therapy device
US7645253B2 (en) * 2001-11-16 2010-01-12 National Quality Care, Inc. Wearable ultrafiltration device
US7597677B2 (en) * 2001-11-16 2009-10-06 National Quality Care, Inc. Wearable ultrafiltration device
US7837766B2 (en) * 2001-11-26 2010-11-23 Gillette Thomas D Systems and methods for reducing off-gassed ozone
JP2003164508A (en) * 2001-12-03 2003-06-10 Taisei Kako Co Ltd Transfusion container
EP1467678A1 (en) * 2001-12-21 2004-10-20 Cardiovasc, Inc. Composite stent with polymeric covering and bioactive coating
KR100889908B1 (en) * 2002-02-14 2009-03-20 가부시키가이샤 오츠카 세이야쿠 코죠 Medical multi-chamber container
EP2298370B1 (en) 2002-02-21 2013-10-30 Design Mentor, Inc. Fluid pump
US7311690B2 (en) 2002-02-25 2007-12-25 Novashunt Ag Implantable fluid management system for the removal of excess fluid
AU2003223187B2 (en) * 2002-02-25 2008-05-22 Sequana Medical Ag Vesicular shunt for the drainage of excess fluid
US7186232B1 (en) * 2002-03-07 2007-03-06 Glaukoa Corporation Fluid infusion methods for glaucoma treatment
US7003684B2 (en) * 2002-03-27 2006-02-21 Via Technologies, Inc. Memory control chip, control method and control circuit
US7744581B2 (en) * 2002-04-08 2010-06-29 Carmel Pharma Ab Device and method for mixing medical fluids
AU2003206609B2 (en) * 2002-04-24 2008-12-11 Ares Trading Sa Device for preparing a medicinal liquid and method for preserving a solution of medicament for injection
US6960233B1 (en) 2002-12-10 2005-11-01 Torax Medical, Inc. Methods and apparatus for improving the function of biological passages
US7043295B2 (en) 2002-04-26 2006-05-09 Medtronic, Inc. Methods and apparatus for delivering a drug influencing appetite for treatment of eating disorders
FR2839261B1 (en) * 2002-05-06 2006-04-07 Ciposa Sa METHOD FOR CLEANING AND QULAIFYING A DIALYSIS FILTER AND MACHINE FOR CARRYING OUT SAID METHOD
US6764761B2 (en) * 2002-05-24 2004-07-20 Baxter International Inc. Membrane material for automated dialysis system
DE10224750A1 (en) * 2002-06-04 2003-12-24 Fresenius Medical Care De Gmbh Device for the treatment of a medical fluid
BR0311585A (en) * 2002-06-05 2005-05-10 Univ Florida Drug delivery system, method for administering an ophthalmic drug to a patient, kit, use thereof, method for preparing the drug delivery system, and article of manufacture
JP3866618B2 (en) 2002-06-13 2007-01-10 エルピーダメモリ株式会社 Memory system and control method thereof
US7998190B2 (en) 2002-06-17 2011-08-16 California Institute Of Technology Intravascular miniature stent pump
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
US20040024285A1 (en) * 2002-06-21 2004-02-05 Helmut Muckter Blood pump with impeller
US7303553B2 (en) * 2002-06-24 2007-12-04 Berlin Heart Gmbh Device for connecting a cannula made of a flexible material with a tube
US20030236483A1 (en) * 2002-06-25 2003-12-25 Ren David H Dual drainage ocular shunt for glaucoma
US20040015041A1 (en) * 2002-07-18 2004-01-22 The University Of Cincinnati Protective sheath apparatus and method for use with a heart wall actuation system for the natural heart
DK1523355T3 (en) 2002-07-22 2019-04-23 Becton Dickinson Co PLASTER-LIKE INFUSION DEVICE
US20040034275A1 (en) * 2002-07-29 2004-02-19 Peter Forsell Multi-material incontinence treatment constriction device
KR20050043899A (en) 2002-08-02 2005-05-11 포텐시아 메디칼 에이쥐 Apparatus for distributing liquid in a patient's body
US6772011B2 (en) 2002-08-20 2004-08-03 Thoratec Corporation Transmission of information from an implanted medical device
US7211114B2 (en) * 2002-08-26 2007-05-01 The Trustees Of Columbia University In The City Of New York Endoscopic gastric bypass
US7214233B2 (en) 2002-08-30 2007-05-08 Satiety, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
FR2844182B1 (en) * 2002-09-11 2004-12-03 Humanoptics Ag CLOSURE PLUG OF A LACRYMAL CANALICLE
EP1403519A1 (en) * 2002-09-27 2004-03-31 Novo Nordisk A/S Membrane pump with stretchable pump membrane
US20040064110A1 (en) 2002-10-01 2004-04-01 Peter Forsell Injection port
US7103418B2 (en) 2002-10-02 2006-09-05 Medtronic, Inc. Active fluid delivery catheter
EP1581326A2 (en) * 2002-10-25 2005-10-05 Pall Corporation Biological fluid filter
US7335215B2 (en) * 2002-11-05 2008-02-26 Damage Control Surgical Technologies, Inc. Method and device for temporary emergency vessel anastomoses
US20040098545A1 (en) 2002-11-15 2004-05-20 Pline Steven L. Transferring data in selectable transfer modes
US7608114B2 (en) * 2002-12-02 2009-10-27 Gi Dynamics, Inc. Bariatric sleeve
US6695004B1 (en) * 2002-12-16 2004-02-24 Alaris Medical Systems, Inc. Magnetic automatic stop valve
US7395117B2 (en) * 2002-12-23 2008-07-01 Cardiac Pacemakers, Inc. Implantable medical device having long-term wireless capabilities
US7141071B2 (en) 2002-12-23 2006-11-28 Python Medical, Inc. Implantable digestive tract organ
US7037343B2 (en) 2002-12-23 2006-05-02 Python, Inc. Stomach prosthesis
CA2512013A1 (en) 2003-01-06 2004-07-22 Atamjit Gill Surgical instrument for the treatment of female urinary incontinence and methods of use
US6826663B2 (en) 2003-01-13 2004-11-30 Rambus Inc. Coded write masking
US7124570B2 (en) * 2003-01-23 2006-10-24 Integrated Vascular Interventional Technologies, L.C. Apparatus and methods for fluid occlusion of an access tube anastomosed to an anatomical vessel
AU2003206302A1 (en) 2003-01-31 2004-08-23 Potencia Medical Ag Incontinence treatment apparatus with connection device
EP1587456B1 (en) 2003-01-31 2007-08-29 Potencia Medical AG Careful impotence treatment apparatus
US7407481B2 (en) 2003-01-31 2008-08-05 Peter Forsell Impotence treatment apparatus with connection device
WO2004066885A1 (en) 2003-01-31 2004-08-12 Potencia Medical Ag Electrically operable incontinence treatment apparatus
DE60312563T2 (en) 2003-01-31 2007-11-22 Instant Communication Ag ELECTRICALLY OPERATED DEVICE FOR IMPOTENCE TREATMENT
DE60316035T2 (en) 2003-01-31 2008-05-15 Potencia Medical Ag DEVICE FOR SAFE INCONTINENCE TREATMENT
US7844338B2 (en) * 2003-02-03 2010-11-30 Enteromedics Inc. High frequency obesity treatment
GB0303432D0 (en) * 2003-02-14 2003-03-19 Council Cent Lab Res Councils Self-cleaning tube
WO2004075855A2 (en) * 2003-02-26 2004-09-10 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluid
DE502004005171D1 (en) * 2003-03-06 2007-11-22 Csl Behring Gmbh Transfer device, in particular for medical fluids
US7185790B2 (en) * 2003-03-20 2007-03-06 Weiler Engineering, Inc. Hermetically sealed container with non-drip opening
US20040193095A1 (en) * 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20040193262A1 (en) * 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US7972616B2 (en) * 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7118525B2 (en) 2003-04-23 2006-10-10 Coleman Edward J Implantable cardiac assist device
US7182744B2 (en) * 2003-04-25 2007-02-27 Medtronic Vascular Method and apparatus for aneurismal treatment
CA2428741A1 (en) 2003-05-13 2004-11-13 Cardianove Inc. Dual inlet mixed-flow blood pump
US20050166006A1 (en) 2003-05-13 2005-07-28 Advanced Micro Devices, Inc. System including a host connected serially in a chain to one or more memory modules that include a cache
US7217236B2 (en) 2003-05-30 2007-05-15 Innovamedica S.A. De C.V. Universal pneumatic ventricular assist device
US7165153B2 (en) * 2003-06-04 2007-01-16 Intel Corporation Memory channel with unidirectional links
WO2005003300A2 (en) * 2003-06-04 2005-01-13 University Of South Carolina Tissue scaffold having aligned fibrils, apparatus and method for producing same, and methods of using same
TW590007U (en) 2003-06-06 2004-06-01 Univ Tamkang Tri-leaflet mechanical heart valve
US6948522B2 (en) * 2003-06-06 2005-09-27 Baxter International Inc. Reconstitution device and method of use
US20040253039A1 (en) * 2003-06-13 2004-12-16 Stenton Richard J. Disposable applicator for topical composition
WO2004110548A1 (en) * 2003-06-17 2004-12-23 Cube Medical A/S Closure with passage slit for a haemostatic valve assembly
US20050027234A1 (en) * 2003-06-18 2005-02-03 Waggoner Donna Jean Surgical implant and method of accessing cerebrospinal fluid
US6798716B1 (en) * 2003-06-19 2004-09-28 Bc Systems, Inc. System and method for wireless electrical power transmission
US7201757B2 (en) 2003-06-20 2007-04-10 Enteromedics Inc. Gastro-esophageal reflux disease (GERD) treatment method and apparatus
US7226441B2 (en) * 2003-06-23 2007-06-05 Codman & Shurtleff, Inc. Catheter with block-overriding system
KR101129516B1 (en) * 2003-07-18 2012-03-29 세키스이가가쿠 고교가부시키가이샤 Hermetically sealed container and vacuum test substance-collecting container
WO2005018507A2 (en) * 2003-07-18 2005-03-03 Ev3 Santa Rosa, Inc. Remotely activated mitral annuloplasty system and methods
US7736494B2 (en) * 2003-07-31 2010-06-15 Acquisci, Inc. Ozone delivery system including a variable pitch gas-fluid contact device
US7314489B2 (en) * 2003-08-20 2008-01-01 Ethicon Endo-Surgery, Inc. Method and apparatus to facilitate nutritional malabsorption
US7217351B2 (en) * 2003-08-29 2007-05-15 Beta Micropump Partners Llc Valve for controlling flow of a fluid
EP1669051A4 (en) * 2003-09-30 2011-06-15 Nipro Corp Medical container and its using method
US8140168B2 (en) 2003-10-02 2012-03-20 Medtronic, Inc. External power source for an implantable medical device having an adjustable carrier frequency and system and method related therefore
US7762977B2 (en) * 2003-10-08 2010-07-27 Hemosphere, Inc. Device and method for vascular access
EP1680155B2 (en) * 2003-10-28 2015-11-04 Baxter International Inc. Dialysis machine with improved integrity test
US7186290B2 (en) * 2004-01-08 2007-03-06 Carrier Corporation Filter system with automatic media refresh
EP2335751B1 (en) * 2004-01-22 2016-04-06 Yehuda Tamari A closed venous-cardiotomy reservoir with improved air handling
EP1563886A1 (en) 2004-01-23 2005-08-17 Fuji Photo Film Co., Ltd. Extraction system
CN101627938B (en) * 2004-02-02 2011-12-21 孕体有限公司 Contraceptive with permeable and impermeable components
US8052669B2 (en) * 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US20050256540A1 (en) * 2004-02-26 2005-11-17 Silver Theodore A Apparatus and method for movement of electricity or fluid into and out of the body
US20050209582A1 (en) * 2004-03-22 2005-09-22 Medtronic Vascular, Inc. Multi-lumen catheter system
US7686825B2 (en) * 2004-03-25 2010-03-30 Hauser David L Vascular filter device
US7488302B1 (en) * 2004-03-29 2009-02-10 Robert Helm Device allowing serial use of clean and alternative blood filters during blood filtration
US20060129028A1 (en) 2004-03-31 2006-06-15 Krakousky Alexander A Potency package
US7993397B2 (en) * 2004-04-05 2011-08-09 Edwards Lifesciences Ag Remotely adjustable coronary sinus implant
EP1740132B1 (en) 2004-04-26 2014-12-31 Synecor, LLC Restrictive and/or obstructive implant for inducing weight loss
US20050245957A1 (en) 2004-04-30 2005-11-03 Medtronic, Inc. Biasing stretch receptors in stomach wall to treat obesity
JP4934024B2 (en) 2004-05-03 2012-05-16 フルフィリウム， インコーポレイテッド Method and system for controlling stomach volume
CA2828619C (en) * 2004-05-05 2018-09-25 Direct Flow Medical, Inc. Prosthetic valve with an elastic stent and a sealing structure
US6949067B1 (en) * 2004-05-11 2005-09-27 Dann Jeffrey A Device and method for enhancing female sexual stimulation
US7222224B2 (en) 2004-05-21 2007-05-22 Rambus Inc. System and method for improving performance in computer memory systems supporting multiple memory access latencies
US7534221B2 (en) * 2004-05-24 2009-05-19 The Trustees Of Columbia University In The City Of New York Devices and methods for protecting against distal embolisms
US7524298B2 (en) * 2004-05-25 2009-04-28 California Institute Of Technology Device and method for treating hydrocephalus
US7112186B2 (en) 2004-05-26 2006-09-26 Shah Tilak M Gastro-occlusive device
US7516029B2 (en) 2004-06-09 2009-04-07 Rambus, Inc. Communication channel calibration using feedback
US20060004317A1 (en) * 2004-06-30 2006-01-05 Christophe Mauge Hydrocephalus shunt
WO2006055052A2 (en) * 2004-07-19 2006-05-26 Michael Gertner Methods and devices for chronic embolic protection
US20060015137A1 (en) * 2004-07-19 2006-01-19 Wasdyke Joel M Retrievable intravascular filter with bendable anchoring members
US20060020239A1 (en) * 2004-07-20 2006-01-26 Geiger Mark A Cerebral spinal fluid flow sensing device
KR100643605B1 (en) * 2004-08-16 2006-11-10 삼성전자주식회사 Adaptive preemphasis apparatus, data communication transmitter, data communication receiver, and adaptive preemphasis method
US8202248B2 (en) * 2004-08-18 2012-06-19 Sequana Medical Ag Dialysis implant and methods of use
WO2006034276A1 (en) * 2004-09-21 2006-03-30 William A. Cook Austrialia Pty. Ltd. Side branch stent graft
EP1805439A1 (en) * 2004-10-28 2007-07-11 Pall Corporation Valve
US7594899B2 (en) * 2004-12-03 2009-09-29 Innfocus, Llc Glaucoma implant device
CN101128171A (en) * 2004-12-16 2008-02-20 I科学干预公司 Ophthalmic implant for treatment of glaucoma
US20060161217A1 (en) 2004-12-21 2006-07-20 Jaax Kristen N Methods and systems for treating obesity
US20060149129A1 (en) 2005-01-05 2006-07-06 Watts H D Catheter with multiple visual elements
US7601162B2 (en) 2005-01-14 2009-10-13 Ethicon Endo-Surgery, Inc. Actuator for an implantable band
US7963989B2 (en) * 2005-01-24 2011-06-21 Technology Advancement Group, Inc. Implantable prosthetic device for connection to a fluid flow pathway of a patient
EP2586386B1 (en) * 2005-01-25 2018-10-31 Covidien LP Structure for permanent occlusion of a hollow anatomical structure
CA2596886C (en) * 2005-02-04 2011-01-04 Amcol International Corporation Extended delivery of ingredients from a fabric softener composition
US8267954B2 (en) * 2005-02-04 2012-09-18 C. R. Bard, Inc. Vascular filter with sensing capability
AU2006214368B2 (en) * 2005-02-15 2011-05-26 Yale University Intrauterine fallopian tube occlusion device and method for use
US7641627B2 (en) * 2005-02-23 2010-01-05 Camras Carl B Method and apparatus for reducing intraocular pressure
US20060212097A1 (en) * 2005-02-24 2006-09-21 Vijay Varadan Method and device for treatment of medical conditions and monitoring physical movements
CA2599965C (en) * 2005-03-04 2014-05-06 Cardiomems, Inc. Communicating with an implanted wireless sensor
US20060224102A1 (en) * 2005-04-05 2006-10-05 Codman & Shurtleff, Inc Subarachnoid epidural shunt
US7801602B2 (en) * 2005-04-08 2010-09-21 Boston Scientific Neuromodulation Corporation Controlling stimulation parameters of implanted tissue stimulators
US20060235269A1 (en) * 2005-04-15 2006-10-19 The University Of Chicago Method, apparatus and kit for bile or pancreatic duct endoscopy
WO2006113394A2 (en) * 2005-04-15 2006-10-26 Surgisense Corporation Surgical instruments with sensors for detecting tissue properties, and systems using such instruments
CA2507142A1 (en) 2005-04-25 2006-10-25 Mohammad Nadeem Qadir Apparatus, devices and methods for contraception, conception and pregnancy
US7984717B2 (en) 2005-04-29 2011-07-26 Medtronic, Inc. Devices for augmentation of lumen walls
KR100588599B1 (en) * 2005-05-03 2006-06-14 삼성전자주식회사 Memory module and memory system
US7569050B2 (en) 2005-05-06 2009-08-04 Medtronic Minimed, Inc. Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion
EP2409671B1 (en) 2005-05-11 2014-06-11 Board Of Regents, The University Of Texas System Device for treating obesity
EP1884259A4 (en) 2005-05-27 2011-03-30 Olympus Corp Device for introduction into subject
US8435279B2 (en) * 2005-06-14 2013-05-07 Advanced Cardiovascular Systems, Inc. Delivery system for a device such as a stent
DE102005027809A1 (en) 2005-06-15 2006-12-28 Q Medial International Ag Closing device for hollow organs
JP4848143B2 (en) * 2005-06-17 2011-12-28 テルモ株式会社 Blood component collection device
US8709069B2 (en) * 2005-07-01 2014-04-29 C. R. Bard, Inc. Flanged graft with trim lines
ATE535279T1 (en) * 2005-07-19 2011-12-15 Shalom Zvi Ben ORGAN SUPPORT SYSTEM
JP2009503549A (en) * 2005-08-02 2009-01-29 バクスター・インターナショナル・インコーポレイテッド Oxygen indicator for use in medical products
WO2007017880A2 (en) 2005-08-11 2007-02-15 Stimplant Ltd. Implantable device for obesity prevention
US20070038232A1 (en) * 2005-08-12 2007-02-15 Kraemer Stefan J M Apparatus and method for securing the stomach to the diaphragm for use, for example, in treating hiatal hernias and gastroesophageal reflux disease
US7699769B2 (en) * 2005-09-01 2010-04-20 Boston Scientific Scimed, Inc. Adjustable surgical sling
US8435224B2 (en) * 2005-09-12 2013-05-07 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds
EP1945150A1 (en) 2005-10-14 2008-07-23 Continence Control Systems International PTY Ltd. A method and apparatus for treating fecal incontinence
US8118750B2 (en) 2005-10-21 2012-02-21 Medtronic, Inc. Flow sensors for penile tumescence
US8366650B2 (en) * 2005-10-24 2013-02-05 Satiogen Pharmaceuticals, Inc. Biliary/pancreatic shunt device and method for treatment of metabolic and other diseases
US8088117B2 (en) * 2005-10-25 2012-01-03 Nicolon Corporation Fill port for a flexible container for relieving or distributing stresses at the fill port
US8543420B2 (en) * 2007-09-19 2013-09-24 Fresenius Medical Care Holdings, Inc. Patient-specific content delivery methods and systems
EP2210632B1 (en) 2005-11-02 2012-01-18 Injectica AG Implantable infusion device with advanceable and retractable needle
EP2545885B1 (en) * 2005-11-02 2022-01-19 MedicalTree Patents Ltd. Artificial valve for implantation
US7368950B2 (en) 2005-11-16 2008-05-06 Montage Technology Group Limited High speed transceiver with low power consumption
US7577039B2 (en) 2005-11-16 2009-08-18 Montage Technology Group, Ltd. Memory interface to bridge memory buses
US7558124B2 (en) 2005-11-16 2009-07-07 Montage Technology Group, Ltd Memory interface to bridge memory buses
US20070167901A1 (en) * 2005-11-17 2007-07-19 Herrig Judson A Self-sealing residual compressive stress graft for dialysis
EP1958608A4 (en) * 2005-11-29 2013-01-23 Otsuka Pharma Co Ltd Multichamber bag and gas barrier film
US7650192B2 (en) * 2005-12-02 2010-01-19 Medtronic, Inc. Passive charge of implantable medical device utilizing external power source and method
US20070150063A1 (en) * 2005-12-22 2007-06-28 Depuy Spine, Inc. Devices for intervertebral augmentation and methods of controlling their delivery
US7720547B2 (en) 2006-01-04 2010-05-18 Kenergy, Inc. Extracorporeal power supply with a wireless feedback system for an implanted medical device
PT2526910E (en) * 2006-01-17 2015-11-18 Transcend Medical Inc Glaucoma treatment device
US8246563B2 (en) * 2006-02-02 2012-08-21 Cardiac Pacemakers, Inc. Cardiac rhythm management device and sensor-suite for the optimal control of ultrafiltration and renal replacement therapies
US20070193632A1 (en) 2006-02-21 2007-08-23 Jianchao Shu Artificial heart valve and rotary pressure porting mechanisms
US8195296B2 (en) 2006-03-03 2012-06-05 Ams Research Corporation Apparatus for treating stress and urge incontinence
WO2007109759A2 (en) 2006-03-22 2007-09-27 C. R. Bard, Inc. Female urinary incontinence treatment device and method
US8070768B2 (en) * 2006-04-19 2011-12-06 Vibrynt, Inc. Devices and methods for treatment of obesity
US20090131959A1 (en) 2006-04-20 2009-05-21 Liquidia Technologies Inc. Biological Vessel Flow Control Devices and Methods
JP5566101B2 (en) * 2006-04-24 2014-08-06 メディカル・インスティル・テクノロジーズ・インコーポレイテッド Needle penetrable and laser resealable freeze-drying apparatus and related methods
CA2650570C (en) * 2006-04-26 2017-06-06 Eastern Virginia Medical School Systems and methods for monitoring and controlling internal pressure of an eye or body part
US20070265675A1 (en) 2006-05-09 2007-11-15 Ams Research Corporation Testing Efficacy of Therapeutic Mechanical or Electrical Nerve or Muscle Stimulation
US8160709B2 (en) 2006-05-18 2012-04-17 Endostim, Inc. Use of electrical stimulation of the lower esophageal sphincter to modulate lower esophageal sphincter pressure
US7991476B2 (en) 2006-05-22 2011-08-02 Empire Bio-Medical Devices, Inc. Method and device for enhanced blood flow
US8002731B2 (en) * 2006-05-30 2011-08-23 Boston Scientific Scimed, Inc. Anti-obesity stent
EP2049039A2 (en) 2006-06-22 2009-04-22 AMS Research Corporation Adjustable tension incontinence sling assemblies
US7828715B2 (en) * 2006-06-29 2010-11-09 Ams Research Corporation Method of treating anal incontinence
US8075471B2 (en) 2006-07-12 2011-12-13 Allegheny-Singer Research Institute Apical torsion device for cardiac assist
DE102006036073A1 (en) * 2006-08-02 2008-02-07 Heise, Michael, Dr.med. Vascular tubular graft
US20080039768A1 (en) * 2006-08-10 2008-02-14 Medtronic, Inc. Implantable devices with photocatalytic surfaces for treating hydrocephalus
US7455663B2 (en) * 2006-08-23 2008-11-25 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US9168355B2 (en) * 2006-09-29 2015-10-27 Covidien Lp Acute hemodialysis catheter assembly
US7738961B2 (en) 2006-10-09 2010-06-15 Endostim, Inc. Method and apparatus for treatment of the gastrointestinal tract
JP2010505556A (en) * 2006-10-09 2010-02-25 ニューロフルーディクス， インコーポレイテッド Cerebrospinal fluid purification system
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US20080103544A1 (en) 2006-10-28 2008-05-01 Weiner Richard L Method of treating female sexual dysfunction
FR2908979A1 (en) 2006-11-28 2008-05-30 Saidi Abdelkader Erectile dysfunction treating device for use during e.g. prostatectomy, has infusing unit for infusing therapeutic solution into cavernous tissue of penis of patient having erectile dysfunction in discontinuous or continuous manner
US8241621B2 (en) * 2006-12-18 2012-08-14 Medistem Laboratories Stem cell mediated treg activation/expansion for therapeutic immune modulation
US7846160B2 (en) 2006-12-21 2010-12-07 Cytyc Corporation Method and apparatus for sterilization
WO2008097905A1 (en) * 2007-02-05 2008-08-14 Boston Scientific Scimed, Inc. Blood access apparatus and method
US7694570B1 (en) * 2007-03-30 2010-04-13 Cosense, Inc Non-invasive dry coupled disposable/reusable ultrasonic sensor
US8469908B2 (en) * 2007-04-06 2013-06-25 Wilson T. Asfora Analgesic implant device and system
US9259233B2 (en) * 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
US20080262466A1 (en) * 2007-04-19 2008-10-23 Steve Smith Storage container
WO2008134064A1 (en) * 2007-04-28 2008-11-06 The Board Of Trustees Of The Leland Stanford Junior University Dynamic and adjustable support devices
US8075472B2 (en) 2007-05-03 2011-12-13 Leviticus-Cardio Ltd. Permanent ventricular assist device for treating heart failure
US7824357B2 (en) * 2007-06-11 2010-11-02 Ibrahim Rashid Al-Rashdan Method and system for preventing contrast associated nephropathy
EP2002855B1 (en) * 2007-06-14 2012-07-11 RenApta B.V. Artificial kidney
GB0713864D0 (en) 2007-07-17 2007-08-29 Sheppard & Charnley Ltd Electric motor/generator assembly
EP2173276A4 (en) * 2007-08-02 2015-07-08 Bio Connect Systems Implantable flow connector
US9234514B2 (en) * 2007-08-27 2016-01-12 Quest Medical, Inc. Two-chamber blood pump
US8002737B2 (en) * 2007-10-04 2011-08-23 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US8696543B2 (en) * 2007-10-11 2014-04-15 Kirk Promotion Ltd. Method for controlling flow of intestinal contents in a patient's intestines
EA033368B1 (en) 2007-10-11 2019-10-31 Implantica Patent Ltd Apparatus for controlling flow in a bodily organ
US8795153B2 (en) * 2007-10-11 2014-08-05 Peter Forsell Method for treating female sexual dysfunction
US9555241B2 (en) * 2007-10-11 2017-01-31 Peter Forsell Method of obtaining male contraception
US10307597B2 (en) * 2007-10-11 2019-06-04 Peter Forsell Method for controlling flow of urine in a patient's urethra, ureter, renal pelvis or bladder
US8992409B2 (en) * 2007-10-11 2015-03-31 Peter Forsell Method for controlling flow in a bodily organ
US10195325B2 (en) * 2007-10-11 2019-02-05 Peter Forsell Method for controlling flow of sperms in a uterine tube
US9949871B2 (en) * 2007-10-11 2018-04-24 Peter Forsell Method for controlling flow of eggs in a uterine tube
US20090248033A1 (en) * 2007-10-11 2009-10-01 Milux Holding S.A. Method for the treatment of gallstones
EP2246080B1 (en) * 2007-10-12 2016-02-10 DEKA Products Limited Partnership An extracorporeal blood flow system
JP5363496B2 (en) * 2007-11-07 2013-12-11 ジャメス ラネ ロドネイ System, method and apparatus for accessing the circulatory system
US7887503B2 (en) * 2007-11-20 2011-02-15 Mark Geiger Method and apparatus for removing harmful proteins from a mammalian's ventricular cerebrospinal fluid
TWI407939B (en) * 2007-11-27 2013-09-11 財團法人國家實驗研究院 System and method for wireless physiological signal integration
BRPI0906467C1 (en) * 2008-01-25 2021-05-25 Gruenenthal Gmbh pharmaceutical dosage form with modified tear-resistant outer shape and controlled release
EP3970664A1 (en) 2008-01-28 2022-03-23 Implantica Patent Ltd. A fluid movement device
US8961448B2 (en) 2008-01-28 2015-02-24 Peter Forsell Implantable drainage device
US9060771B2 (en) * 2008-01-29 2015-06-23 Peter Forsell Method and instrument for treating obesity
US20090198271A1 (en) * 2008-01-31 2009-08-06 Rainbow Medical Ltd. Electrode based filter
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
EP2096566B1 (en) * 2008-02-29 2018-04-04 Fresenius Medical Care Holdings, Inc. Instructional media system for dialysis machine
FI123247B (en) 2008-03-19 2013-01-15 Aalto Korkeakoulusaeaetioe Intracorporeal bone distribution device
EP2273947B1 (en) * 2008-04-03 2018-05-16 Cook Medical Technologies LLC Self cleaning devices and systems
US7987853B2 (en) * 2008-04-25 2011-08-02 Conceptus, Inc. Devices and methods for occluding a fallopian tube
AU2008357095B2 (en) * 2008-05-26 2014-03-13 Yeda Research And Development Co. Ltd. Methods of treating cancer of the central nervous system
US7988849B2 (en) * 2008-06-03 2011-08-02 Baxter International Inc. Customizable personal dialysis device having ease of use and therapy enhancement features
EP3298995A1 (en) * 2008-06-25 2018-03-28 Novartis AG Ocular implant with shape change capabilities
US8172823B2 (en) * 2008-07-03 2012-05-08 Baxter International Inc. Port assembly for use with needleless connector
US8057679B2 (en) * 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US20100152640A1 (en) * 2008-09-05 2010-06-17 Imtecbiomedical, Inc. Methods and apparatus for vascular access
US10668196B2 (en) 2008-10-10 2020-06-02 Peter Forsell Heart assisting device
US10226329B2 (en) 2008-10-10 2019-03-12 Peter Forsell Artificial valve
US11628053B2 (en) 2008-10-10 2023-04-18 Peter Forsell Variable sling for urinary continence
US20110196484A1 (en) 2008-10-10 2011-08-11 Milux Holding Sa Heart help method
EP3120896A1 (en) * 2008-10-10 2017-01-25 Kirk Promotion LTD. A system, an apparatus, and a method for treating a sexual dysfunctional female patient
EP2349170B1 (en) 2008-10-10 2023-09-27 Implantica Patent Ltd. Apparatus for the treatment of female sexual dysfunction
EP2349106B1 (en) 2008-10-10 2017-01-11 Kirk Promotion LTD. System for the treatment of male sexual dysfunction
US8475355B2 (en) 2008-10-10 2013-07-02 Milux Holding S.A. Heart help device, system, and method
US9839503B2 (en) * 2008-10-10 2017-12-12 Peter Forsell Implantable device for internal urinary control
EP2349096B1 (en) 2008-10-10 2021-01-27 MedicalTree Patent Ltd. An improved artificial valve
CA3126252A1 (en) 2008-10-10 2010-04-15 Medicaltree Patent Ltd. Heart help pump, system, and method
EP2346456B1 (en) 2008-10-10 2021-04-07 Implantica Patent Ltd. An apparatus for temporary male contraception
WO2010042032A1 (en) 2008-10-10 2010-04-15 Milux Holding S.A. Fastening means for implantable medcial control assembly
EP3689318A1 (en) 2008-10-10 2020-08-05 MedicalTree Patent Ltd. Heart help device and system
US9452045B2 (en) 2008-10-10 2016-09-27 Peter Forsell Artificial valve
EP2349076B1 (en) 2008-10-10 2018-06-13 Kirk Promotion LTD. A system, an apparatus for treating a sexual dysfunctional female patient
EP2349083B1 (en) 2008-10-10 2020-06-17 Implantica Patent Ltd. Artificial stomach
BRPI0919860B8 (en) 2008-10-31 2021-06-22 Implantica Patent Ltd implantable device and system for bone adjustment, operable with wireless power transmission
US8523838B2 (en) * 2008-12-15 2013-09-03 Carmel Pharma Ab Connector device
US8679090B2 (en) * 2008-12-19 2014-03-25 Icu Medical, Inc. Medical connector with closeable luer connector
MX365189B (en) * 2009-01-29 2019-05-27 Implantica Patent Ltd Obesity treatment.
EP2218952B1 (en) * 2009-02-12 2013-02-27 Sophysa Device for mechanical localisation and reading the setting of an adjustable valve
WO2010096822A2 (en) * 2009-02-23 2010-08-26 Qlt Plug Delivery, Inc. Lacrimal implants and related methods
US8430831B2 (en) * 2009-02-25 2013-04-30 The Invention Science Fund I, Llc Device, system, and method for controllably reducing inflammatory mediators in a subject
JP5449525B2 (en) * 2009-04-03 2014-03-19 クック メディカル テクノロジーズ エルエルシー Delivery system for a magnetic anastomosis device
US9173760B2 (en) * 2009-04-03 2015-11-03 Metamodix, Inc. Delivery devices and methods for gastrointestinal implants
CN102481450B (en) 2009-04-07 2015-09-16 威斯特天主教保健中心 uterine electrical stimulation system and method
US9949812B2 (en) * 2009-07-17 2018-04-24 Peter Forsell Vaginal operation method for the treatment of anal incontinence in women
US10952836B2 (en) * 2009-07-17 2021-03-23 Peter Forsell Vaginal operation method for the treatment of urinary incontinence in women
US8632485B2 (en) * 2009-11-05 2014-01-21 Fresenius Medical Care Holdings, Inc. Patient treatment and monitoring systems and methods
US8388566B2 (en) * 2010-04-29 2013-03-05 Sorin Group Italia, S.r.l. Oxygenator with integrated arterial filter including filter frame
JP6058530B2 (en) * 2010-05-06 2017-01-11 アイシーユー・メディカル・インコーポレーテッド Medical connectors including sealable luer connectors
US8545430B2 (en) * 2010-06-09 2013-10-01 Transcend Medical, Inc. Expandable ocular devices
CN103328976B (en) * 2010-11-01 2016-08-10 B.R.A.H.M.S有限公司 There is prognosis and the risk assessment of the patient of nonspecific main suit
IT1403656B1 (en) * 2011-01-28 2013-10-31 Frattini Paolo Giuseppe Gobbi HERMETIC CLOSURE CONNECTOR, PERFORTABLE WITHOUT NEEDLE AND AUTOMATICALLY CLOSABLE FOR TIGHTENING, FOR FLEXIBLE PIPES INTENDED FOR THE COLLECTION AND DISTRIBUTION OF LIQUID SOLUTIONS FOR PHARMACOLOGICAL AND / OR NUTRITIONAL USE.
DE102011010067A1 (en) * 2011-02-01 2012-08-02 Fresenius Medical Care Deutschland Gmbh Method and device for controlling an extracorporeal blood treatment device
US8888732B2 (en) * 2011-03-11 2014-11-18 Apollo Endosurgery, Inc. Intraluminal sleeve with active agents
EP2716310B1 (en) * 2011-05-27 2017-02-01 Grifols, S.A. Priming anticoagulant line for blood extraction
US9295613B2 (en) * 2011-12-13 2016-03-29 Fenwal, Inc. Container with pH indicator
US9270134B2 (en) * 2012-01-27 2016-02-23 Medtronic, Inc. Adaptive rate recharging system
US9225190B2 (en) * 2012-09-07 2015-12-29 Manufacturers And Traders Trust Company Implant current controlled battery charging based on temperature
WO2014052438A1 (en) * 2012-09-25 2014-04-03 Regents Of The University Of Minnesota Methods for making and using antimicrobial peptides
WO2014098810A1 (en) * 2012-12-18 2014-06-26 Empire Technology Development, Llc Vascular reinforcement device
WO2014113483A1 (en) * 2013-01-15 2014-07-24 Metamodix, Inc. System and method for affecting intestinal microbial flora
US9579457B2 (en) * 2013-03-15 2017-02-28 Flint Hills Scientific, L.L.C. Method, apparatus and system for automatic treatment of pain
EP2967927A4 (en) * 2013-03-15 2016-10-12 Merit Medical Systems Inc Esophageal stent

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151922A1 (en) * 1998-05-13 2002-10-17 Michael Hogendijk Apparatus and methods for removing emboli during a surgical procedure
WO2001012108A1 (en) * 1999-08-12 2001-02-22 Potencia Medical Ag Medical implant apparatus with wireless energy transmission
WO2001045590A2 (en) * 1999-12-23 2001-06-28 Percusurge, Inc. Strut design for an occlusion device
US20020165575A1 (en) * 2001-05-07 2002-11-07 Saleh Fathy M.A. Vascular filtration device
WO2005072169A2 (en) * 2004-01-20 2005-08-11 Massachusetts General Hospital Permanent thrombus filtering stent
US20050266042A1 (en) * 2004-05-27 2005-12-01 Medtronic Vascular, Inc. Methods and apparatus for treatment of aneurysmal tissue
US20060224177A1 (en) * 2005-04-01 2006-10-05 Stephanos Finitsis Thrombus removal system and process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2244662A4 *

Also Published As

Publication number Publication date
EP2244760B1 (en) 2022-06-08
CA3116266A1 (en) 2009-08-06
ES2877766T3 (en) 2021-11-17
US9457172B2 (en) 2016-10-04
US20100324591A1 (en) 2010-12-23
US20100318117A1 (en) 2010-12-16
EP3964243A1 (en) 2022-03-09
CA2749771A1 (en) 2009-08-06
US20200061354A1 (en) 2020-02-27
US20200337822A1 (en) 2020-10-29
WO2009096853A1 (en) 2009-08-06
US20240058736A1 (en) 2024-02-22
AU2009209515A1 (en) 2009-08-06
EP2244662A1 (en) 2010-11-03
WO2009096856A1 (en) 2009-08-06
EP2244662B1 (en) 2021-09-29
US20150157836A1 (en) 2015-06-11
US20220288361A1 (en) 2022-09-15
US20100318118A1 (en) 2010-12-16
US20170021072A1 (en) 2017-01-26
US11291808B2 (en) 2022-04-05
US20100318116A1 (en) 2010-12-16
CA2749766A1 (en) 2009-08-06
US11839848B2 (en) 2023-12-12
US10384042B2 (en) 2019-08-20
AU2009209514A1 (en) 2009-08-06
US20210046294A1 (en) 2021-02-18
EP2244760B8 (en) 2022-07-20
US20240082776A1 (en) 2024-03-14
CA2749759A1 (en) 2009-08-06
WO2009096851A1 (en) 2009-08-06
US20100312164A1 (en) 2010-12-09
US20220168550A1 (en) 2022-06-02
CA3187608A1 (en) 2009-08-06
US11826690B2 (en) 2023-11-28
US20180093081A1 (en) 2018-04-05
CA2749759C (en) 2018-05-15
AU2009209518A1 (en) 2009-08-06
US12005386B2 (en) 2024-06-11
US20210308434A1 (en) 2021-10-07
EP2244760A1 (en) 2010-11-03
US10463843B2 (en) 2019-11-05
EP2244662A4 (en) 2017-07-05
US11253684B2 (en) 2022-02-22
US10729894B2 (en) 2020-08-04
EP3928809A1 (en) 2021-12-29
CA2749766C (en) 2022-07-12
US8961448B2 (en) 2015-02-24
US20200155819A1 (en) 2020-05-21
US9789290B2 (en) 2017-10-17
EP2244758A1 (en) 2010-11-03
EP2244759A4 (en) 2016-12-07
ES2901553T3 (en) 2022-03-22
EP2244663A4 (en) 2017-07-05
US11660562B2 (en) 2023-05-30
CA2999337A1 (en) 2009-08-06
JP5643113B2 (en) 2014-12-17
EP2244758A4 (en) 2016-12-14
EP4088772A1 (en) 2022-11-16
CA2749771C (en) 2018-05-01
EP2244760A4 (en) 2017-01-25
EP2244759A1 (en) 2010-11-03
US20170304597A1 (en) 2017-10-26
WO2009096852A1 (en) 2009-08-06
EP2244663A1 (en) 2010-11-03
JP2011510739A (en) 2011-04-07
EP2244663B1 (en) 2021-04-28
CA2999337C (en) 2023-03-07
US9694165B2 (en) 2017-07-04
US11045631B2 (en) 2021-06-29
US20240091697A1 (en) 2024-03-21

Similar Documents

Publication Publication Date Title
US11839848B2 (en) Blood clot removal device, system, and method
AU2021200756B2 (en) Blood Clot Removal Device, System, And Method

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09706196

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 12864828

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2009706196

Country of ref document: EP