US3683929A - Device for draining cerebrospinal fluid in cases of hydrocephalus - Google Patents

Device for draining cerebrospinal fluid in cases of hydrocephalus Download PDF

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US3683929A
US3683929A US3683929DA US3683929A US 3683929 A US3683929 A US 3683929A US 3683929D A US3683929D A US 3683929DA US 3683929 A US3683929 A US 3683929A
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device
flexible
pumping chamber
tubular
upstream
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John W Holter
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EXTRACORPOREAL MEDICAL SPECIALTIES Inc
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EXTRACORPOREAL MEDICAL
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliances for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006Cerebrospinal drainage; Accessories therefor, e.g. valves

Abstract

A device for the draining of cerebrospinal fluid (CSF) in cases of hydrocephalus, of the type having upstream and downstream normally closed check valves which are designed to pass CSF in one direction only in response to predetermined values of fluid pressure, and having a pumping chamber between the valves for manipulation to insure that the device is functioning properly, the pumping chamber having an enlarged bulbous portion with a lateral dimension substantially greater than the diameter of the remainder of the device, the enlarged bulbous portion being molded to shape from medical grade silicone rubber, and having flow direction or other indicia molded thereon.

Description

United States Patent Holter [54] DEVICE FOR DRAINING CEREBROSPINAL FLUID IN CASES OF HYDROCEPHALUS [72] Inventor: John W. Halter, St. John, V.l. [73] Assignee: Extracorporeal Medical Specialties,

[22] Filed: Dec. 28, 1970 [21] Appl. No.: 101,906

52 US. Cl. ..12s/3s0 v, 128/231 511 1m, (:1. ..A61m 01/00, A6ln'1 27/00 58 Field 6: Search 128/350 R, 350 v, 247, 231

[56] References Cited UNITED STATES PATENTS 2,969,066 1/1961 l-lolter et a1 ..12s/350 v 3,566,875 3/1971 Stoehr ..128/350 v 3,492,996 2/1970 3,542,026 11/1970 Bledsoe ..l28/350V 15] 3,683,929 [451 Aug. 15, 1972 506,882 10/1893 Longden ..l28/247 208,062 9/1878 Bliss et al.., ..l28/247 Primary Examiner-Dalton L. Truluck Attorney-Connolly & Hut:

[57] ABSTRACT A device for the draining of cerebrospinal fluid (CSF) in cases of hydrocephalus, of the type having upstream and downstream normally closed check valves which are designed to pass CSF in one direction only in response to predetermined values of fluid pressure, and having a pumping chamber between the valves for manipulation to insure that the device is functioning properly, the pumping chamber having an enlarged bulbous portion with a lateral dimension substantially greater than the diameter of the remainder of the device, the enlarged bulbous portion being molded to shape from medical grade silicone rubber, and having flow direction or other indicia molded thereon.

5 2Claims,3DrawingFigures DEVICE FOR DRAINING CEREBROSPINAL FLUID IN CASES OF HYDROCEPHAL'US BACKGROUND OF THE INVENTION This invention relates to the field of surgical devices designed for the draining or shunting of cerebrospinal fluid principally to the jugular vein in cases of hydrocephalus, and more particularly to an improvement in a valve device of the type disclosed in Holter and Spitz Pat. No. 2,969,066 granted Jan. 24, 1961.

The valve device disclosed in the aforesaid Holter et al patent has been widely accepted by the medical and surgical profession, and has prompted further research and development by others resulting in several commercially available devices of the same general character. This development has saved numerous lives and relieved considerable human suffering, but the valve devices presently on the market, including that of the Holter et al patent, still have certain deficiencies.

First, the pumping chamber on most of such valve devices is fabricated from a length of standard extruded tubing, and is thus never larger in diameter than the check valve portions of the valve device. This presents a-troublesome problem because there is a substantial danger that the valve assembly may be extruded through a rongeured slot in the skull, especially with the delicate skull of infants. Another problem is that such tubing does not provide the desired positive digital pressure feel in determining if and where a blockage of the system should occur. Furthermore, the tubing presently employed for the pumping chamber presents an unfortunately narrow target for the needle injection of medicines, contrast medium or other substances that may be desired by the attendant physician. In addition, an unhappy compromise must be struck with respect to the diameter of the tubing, because if it is sufficiently small to make a fluid-tight stretch fit with the valve portions at either end, then the central pumping chamber portion is too narrow to be of optimal use, and utilization of larger diameter tubing requires additional closure means at the ends to insure fluid-tight fittings. Finally, with extruded tubing there is no adequate means of including permanently visible indicia to indicate the direction of flow or identify other flow characteristics of the valve device; labels for this purpose have proved impractical because of the difficulty of insuring that they remain in place during sterilization and the like. Finally, with valves of this nature it has become apparent that some means of in creasing the pumping volume should be provided to improve the flushing characteristics for freeing the sensitive slit valves of tissue fragments and occasional foreign matter by accelerating contained fluid to flush or circulate fresh CSF into static areas of the assembly.

Thus, there is a recognized need for a valve device for draining CSF in cases of hydrocephalus which solves the foregoing problems.

SUMMARY OF THE INVENTION This invention provides a device for the draining of CSF in cases of hydrocephalus which comprises first and second check valves which are normally closed and which are designed to open and permit flow of fluid in response to a predetermined value of fluid pressure on the upstream side thereof, and a flexible pumping chamber between the first and second valves which is directly formed to final shape from a flexible, tissue compatible material such as medical grade silicone rubber and which includes upper and lower tubular portions adapted to connect with adjacent tubular members and, by virtue of the inherent elastic charac teristics of the material, to provide a fluid-tight connection without need of auxiliary clamping devices, and having a mid-section with an enlarged bulbous portion with a lateral, dimension substantially greater than the diameter of the upper and lower tubular portions. The enlarged bulbous portion of the flexible pumping chamber may have indicia indicating the direction of fluid flow and/or other valve flow characteristics molded or otherwise included directly thereon. The enlarged bulbous portion in the presently preferred embodiment is generally circular in lateral cross-section, and the upper and lower tubular portions thereof are positioned co-axially with respect to the enlarged bulbous portion.

BRIEF DESCRIPTION OF THE DRAWINGS Numerous advantages of the present invention will become apparent to one skilled in the art from a reading of the detailed description in conjunction with the accompanying drawings, wherein similar reference characters refer to similar parts, and in which:

FIG. 1 is an elevational view showing the valve device of this invention;

FIG. 2 is an enlarged longitudinal sectional view showing the pumping and drainage portions of the device; and

FIG. 3 is a diagram showing the application of the device to a patient.

DETAILED DESCRIPTION Referring in more particularity to the drawings, the device comprises a flexible pumping chamber 2, which may be of the order of three inches in length, which is closed at its upper end by a first check valve indicated generally at 4 and at its lower end by a second check valve indicated generally at 6. To the upper check valve assembly 4 there is affixed a tube 8 which may be of silicone rubber and which is provided with openings 10 for the reception of the cerebrospinal fluid, the end of the tube being desirably closed as indicated at 12.

Associated with the lower valve assembly 6 is a tubular member 14 which is desirably of silicone rubber and which is arranged to enter and be secured within the jugular vein, as in the principal use.

Reference may now be made to FIG. 2 which shows the details of the valves 4 and 6 A member 16 preferably of stainless steel or other metal which will not be corroded by body fluids is provided with a flange l8 and with an extension 19 having a locking ridge on its outer wall tightly embraced by the open end of a thimble 20 desirably of silicone rubber which is provided with a slit 22 such as may be made by a sharp blade and which functions as the actual valve. An identification band 24 surrounds an upstream tubular member in the form of a stainless steel sleeve 26 which is secured to the flange 18 of the member 16. The thimble 20 is desirably molded directly to shape, and it has a flange 28 extending radially outward around its upstream end to secure a good seal between the flange 18 and an internal shoulder 30 on the tubular member 26.

A small coil spring 31 may be included within the upstream thimble to prevent inadvertant collapse thereof. The stem of the member 16 is corrugated to secure well the tube 8 which may be bound thereon by tying with silk thread. The sleeve 26 may also be corrugated to form a connection with the flexible pumping chamber 2 without use of silk thread or other clamping arrangements, as explained in more detail below.

The outlet valve 6 shown in the lower portion of FIG. 2 is generally similar to the inlet valve, comprising a member 32 provided with a flange 34 and carrying on an extension with a locking ridge a thimble 36 which is slitted as at 38 in the same fashion as the thimble 20, and optionally may contain a coil spring in similar fashion. A shoulder 40 secures the flange of this thimble on the member 32 and the interposed flange provides a good gasket closure. A downstream tubular member in the form of a sleeve 42, which carries the shoulder 40, encloses the entire assembly just described, and the sleeve 42 is connected to a reduction member 44 to receive the tubular member 14, the member 44 being corrugated so that the tube 14 may be secured thereon by suitable'clamping means such as tying with silk thread.

The flexible pumping chamber 2 shown in the midportion of FIG. 2 is located between the first 4 and second 6 check valves. It is formed to final shape by a process such as molding from a tissue compatible material such as medical grade silicone rubber. The chamber includes an upper tubular portion 46 and a lower tubular portion 48 which are adapted to connect with the upstream tubular sleeve member 26 and the downstream tubular sleeve member 42, respectively. The tubular portions 46 and 48 areinitially molded or otherwise formed with a diameter which is'sufflciently small that these portions may be stretched around the sleeve members 26, 42 to provide a permanent, fluidtight connection without the necessity of silk thread or other closure devices.

The mid-section of the flexible pumping chamber has an enlarged bulbous portion 50 with a normal lateral dimension substantially greater than the diameter of the upper and lower tubular portions 46, 48 when they are stretched over the upstream and downstream tubular members 26, 42, respectively. The enlarged portion 50 is generally circular in lateral cross-section, although other shapes are contemplated, and the upper and lower tubular portions 46, 48 are positioned substantially co-axially with respect to the enlarged bulbous portion.

An important aspect of the present invention is the provision of indicia indicating the direction of fluid flow 52 and/or other valve flow characteristics 54 molded directly into the outer surface of the silicone rubber. This provides positive identification and in sures that the attendant physician does not erroneously apply the device to the patient in the reverse direction. It has been found that the direct molding of such indicia overcomes the difficulty of insuring that labels and the like remain in place during sterilization.

The entire assembly is of quite small lateral dimension, and the directly molded pumping chamber according to this invention provides a noticeably enlarged and easy to identify portion thereof. The average external diameter of the tubular portions 46 and 48 is about v provides a much more positive digital pressure three-sixteenth inch, and the device is customarily recessed in a similarly dimensioned rongeured slot in the skull. The enlarged bulbousportion 50 of the valve according to this invention prevents accidental extrusion of the device through the skull, especially the delicate skull of infants, after repeated manipulation of the pumping portion of the device.

The thimbles 20, 36 in one exemplary embodiment have external diameters of the order of one-eighth inch and wall thickness of approximately 0.020 inch, the

slits 22 and 38 being about three-sixteenth inch in length. Under these conditions both valves open to permit forward flow under a pressure gradient between the tubes 8 and 14 of the order of thirty millimeters of water, opening occurring by the dilation of the thimbles 20 and 36 to open the slits 22 and 38. On the other hand, reverse flow is completely stopped against any pressure gradient which may be expected during use, closing taking place due to the resiliency of the thimbles when there is no pressure gradient and remaining closed until the forward pressure gradient occurs. In the forward direction, the valve will pass small particles of tissue which may occur in the ventricular fluid, and the enlarged bulbous portion 50 of the pumping chamber according to this invention provides a significantly larger pumping volume which produces a higher fluid velocity to improve the cleaning and flushing characteristics of the slit valves.

The use of the device is illustrated in FIG. 3. The device is inserted beneath the skin with the tube 8 extending throughan opening 56 in the skull. The device below the tube 8 is threaded under the skin and by means of a lower incision the tube 14 is generally inserted into and secured in the jugular vein 58. Proper function may be determined by pressing upon the skin covering the enlarged bulbous portion 50. If unusual resistance to pressure is noted indicating that the outlet side of the shunt system may have become closed, the situation may generally be rectified by producing a pumping action by pressure and release on the enlarged bulbous portion 50. In the event that the inlet side of the, shunt system should be clogged, that fact will be evident since the bulb will not expand to original size upon release of pressure. The enlarged bulbous portion feel in determining if and where a blockage should occur, a notable deficiency with previous valves of this character. Moreover, the enlarged portion provides a more readily accessible target in which to needle inject medicines, contrast medium or other substances that may be desired by the attendant physician.

While the above described embodiment constitutes the presently preferred mode of practicing this invention, other embodiments and equivalents are included within the scope of the actual invention, which is claimed as:

l. A device for the draining of cerebrospinal fluid in cases of hydrocephalus comprising a non-flexible upstream tubular member adapted to be positioned along a rongeured slot in the patients skull, a non-flexible downstream tubular member, a normally closed oneway check valve supported within each tubular member, the check valves each including a thin walled flexible member in the form of a thimble provided with slit means expandable between open and closed positions and being arranged to open and permit flow of fluid therethrough in response to a predetermined value of fluid pressure on the upstream side thereof, a flexible pumping chamber directly molded to shape from flexible tissue compatible material, the pumping chamber including an upper tubular portion stretched around the upstream tubular member and a lower tubu lar portion stretched around the downstream tubular member to provide fluid-tight connections thereto and to position the upstream and downstream tubular mem bers generally co-axially with respect to each other, the pumping chamber further including a mid-section having an enlarged bulbous portion with a lateral dimension substantially greater than the diameter of the upper and lower tubular portions when they are stretched around the upstream and downstream tubular members, the lateral dimension of the bulbous portion being sufficiently great, to prevent the device from being inadvertantly depressed. through the patients skull in the area of the rongeured slot.

2. A device for the draining of cerebrospinal fluid as in claim 1 wherein the flexible pumping chamber is directly molded to shape from medical grade silicone rubber, the lateral dimension of the bulbous portion is sufficiently great to be readily distinguished by fingertip feel from the upper and lower tubular portions despite an overlying layer of the patient's skin, and at least one of the non-flexible tubular members includes identification indicia thereon which is visible through the silicone rubber tubular portion stretched therearound.

Claims (2)

1. A device for the draining of cerebrospinal fluid in cases of hydrocephalus comprising a non-flexible upstream tubular member adapted to be positioned along a rongeured slot in the patient''s skull, a non-flexible downstream tubular member, a normally closed one-way check valve supported within each tubular member, the check valves each including a thin walled flexible member in the form of a thimble provided with slit means expandable between open and closed positions and being arranged to open and permit flow of fluid therethrough in response to a predetermined value of fluid pressure on the upstream side thereof, a flexible pumping chamber directly molded to shape from flexible tissue compatible material, the pumping chamber including an upper tubular portion stretched around the upstream tubular member and a lower tubular portion stretched around the downstream tubular member to provide fluid-tight connections thereto and to position the upstream and downstream tubular members generally co-axially with respect to each other, the pumping chamber further including a mid-section having an enlarged bulbous portion with a lateral dimension substantially greater than the diameter of the upper and lower tubular portions when they are stretched around the upstream and downstream tubular members, the lateral dimension of the bulbous portion being sufficiently great to prevent the device from being inadvertantly depressed through the patient''s skull in the area of the rongeured slot.
2. A device for the draining of cerebrospinal fluid as in claim 1 wherein the flexible pumping chamber is directly molded to shape from medical grade silicone rubber, the lateral dimension of the bulbous portion is sufficiently great to be readily distinguished by fingertip feel from the upper and lower tubular portions despite an overlying layer of the patient''s skin, and at least one of the non-flexible tubular members includes identificAtion indicia thereon which is visible through the silicone rubber tubular portion stretched therearound.
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Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315952A1 (en) * 1975-06-30 1977-01-28 Cordis Corp A diverter valve has two cerebrospinal fluid
US4215695A (en) * 1978-02-22 1980-08-05 Medical Devices, Inc. Fluid draining system
US4610658A (en) * 1985-02-21 1986-09-09 Henry Buchwald Automated peritoneovenous shunt
US4657530A (en) * 1984-04-09 1987-04-14 Henry Buchwald Compression pump-catheter
US4675003A (en) * 1985-12-23 1987-06-23 Cordis Corporation Three stage pressure regulator valve
US4676772A (en) * 1985-12-23 1987-06-30 Cordis Corporation Adjustable implantable valve having non-invasive position indicator
US4681559A (en) * 1985-12-23 1987-07-21 Cordis Corporation Plural valve three stage pressure relief system
US4685912A (en) * 1986-03-05 1987-08-11 Patent Research And Development Corp. I.V. drip chamber with built-in pump activated by external means
US4714459A (en) * 1985-12-23 1987-12-22 Cordis Corporation Three stage intracranial pressure control valve
US4729762A (en) * 1985-12-23 1988-03-08 Cordis Corporation Three stage implantable pressure relief valve with adjustable valve stem members
EP0276356A1 (en) * 1987-01-29 1988-08-03 Pudenz-Schulte Medical Research Corporation Siphon control device
US4776838A (en) * 1983-12-08 1988-10-11 Cordis Corporation Three stage valve
US4776839A (en) * 1986-10-21 1988-10-11 Cordis Corporation Three stage implantable pressure relief valve with improved valve stem member
US4781672A (en) * 1986-10-21 1988-11-01 Cordis Corporation Three stage implantable flow control valve with improved valve closure member
US4861331A (en) * 1988-03-24 1989-08-29 Pudenz-Schulte Medical Research Corp. Implantable shunt system and method of assembly
US4867740A (en) * 1988-03-24 1989-09-19 Pudenz-Schulte Medical Research Corp. Multiple-membrane flow control valve and implantable shunt system
US4921488A (en) * 1988-01-15 1990-05-01 Maitz Carlos A Aspirator device for body fluids
US5024612A (en) * 1988-12-19 1991-06-18 Minnesota Mining And Manufacturing Company External ear canal pressure regulating device and tinnitus suppression device
US5342329A (en) * 1991-10-11 1994-08-30 Inmed Ltda. Portable disposable device for post-surgical suction
US5368556A (en) * 1992-01-22 1994-11-29 Cordis Corporation Implantable drainage valve for the treatment of hydrocephalus
US5769093A (en) * 1994-12-09 1998-06-23 Xomed Surgical Products, Inc. Method of relieving synovial fluid pressure
US5830172A (en) * 1991-04-11 1998-11-03 Leveen; Harry H. Ascites valve
US20050113766A1 (en) * 2003-11-26 2005-05-26 Jim Mottola Primer bulb for contrast media delivery system
US20060079853A1 (en) * 2004-10-12 2006-04-13 C. R. Bard, Inc. Corporeal drainage system
US20060129111A1 (en) * 2004-12-09 2006-06-15 Mottola Jim D Burette float and drainage aperture
US20060258970A1 (en) * 2005-04-29 2006-11-16 Medtronic, Inc. Anti-thrombogenic venous shunt system and method
US20060264850A1 (en) * 2004-12-09 2006-11-23 Merit Medical Systems, Inc. Valve assembly with chamber vent and fluid deflector
US20070073270A1 (en) * 2005-09-26 2007-03-29 C. R. Bard, Inc. Catheter connection systems
US20090259199A1 (en) * 2008-04-14 2009-10-15 Lampropoulos Fred P Contrast media diffusion system
US20100021860A1 (en) * 2008-07-28 2010-01-28 Stephanie Christman Ergonomic high volme evacuator system
US20100042039A1 (en) * 2006-04-25 2010-02-18 Medtronic, Inc. Cerebrospinal fluid shunt having long term anti-occlusion agent delivery
US8636721B2 (en) 2003-11-20 2014-01-28 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Portable hand pump for evacuation of fluids
US20150157836A1 (en) * 2008-01-28 2015-06-11 Peter Mats Forsell Implantable drainage device
WO2015200841A1 (en) * 2014-06-27 2015-12-30 Lazarus Harrison M Surgical kits for body cavity drainage and related methods
US9393387B1 (en) * 2012-08-16 2016-07-19 Martin Mayse Systems and methods for draining bodily fluid via an intercostal pump
US9604033B2 (en) 2014-06-27 2017-03-28 Harrison M. Lazarus Body cavity drainage devices with locking devices and related methods
US9821097B2 (en) 2014-06-27 2017-11-21 Merit Medical Systems, Inc. Body cavity drainage devices including drainage tubes having inline portions and related methods
US10029036B2 (en) 2014-06-27 2018-07-24 Merit Medical Systems, Inc. Placement tools for body cavity drainage devices and related methods

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US208062A (en) * 1878-09-17 Improvement in syringes
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US2969066A (en) * 1956-10-02 1961-01-24 Holter Company Device for draining ventricular fluid in cases of hydrocephalus
US3492996A (en) * 1966-02-09 1970-02-03 Dow Corning Ventriculo-atrial shunt
US3542026A (en) * 1968-07-23 1970-11-24 Billy M Bledsoe Thoracostomy device
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Patent Citations (6)

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US208062A (en) * 1878-09-17 Improvement in syringes
US506882A (en) * 1893-10-17 Charles e
US2969066A (en) * 1956-10-02 1961-01-24 Holter Company Device for draining ventricular fluid in cases of hydrocephalus
US3492996A (en) * 1966-02-09 1970-02-03 Dow Corning Ventriculo-atrial shunt
US3542026A (en) * 1968-07-23 1970-11-24 Billy M Bledsoe Thoracostomy device
US3566875A (en) * 1969-05-20 1971-03-02 Richard K Stoehr Device for draining cerebrospinal fluid

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315952A1 (en) * 1975-06-30 1977-01-28 Cordis Corp A diverter valve has two cerebrospinal fluid
US4215695A (en) * 1978-02-22 1980-08-05 Medical Devices, Inc. Fluid draining system
US4776838A (en) * 1983-12-08 1988-10-11 Cordis Corporation Three stage valve
US4657530A (en) * 1984-04-09 1987-04-14 Henry Buchwald Compression pump-catheter
US4610658A (en) * 1985-02-21 1986-09-09 Henry Buchwald Automated peritoneovenous shunt
US4675003A (en) * 1985-12-23 1987-06-23 Cordis Corporation Three stage pressure regulator valve
US4676772A (en) * 1985-12-23 1987-06-30 Cordis Corporation Adjustable implantable valve having non-invasive position indicator
US4681559A (en) * 1985-12-23 1987-07-21 Cordis Corporation Plural valve three stage pressure relief system
US4714459A (en) * 1985-12-23 1987-12-22 Cordis Corporation Three stage intracranial pressure control valve
US4729762A (en) * 1985-12-23 1988-03-08 Cordis Corporation Three stage implantable pressure relief valve with adjustable valve stem members
US4685912A (en) * 1986-03-05 1987-08-11 Patent Research And Development Corp. I.V. drip chamber with built-in pump activated by external means
US4776839A (en) * 1986-10-21 1988-10-11 Cordis Corporation Three stage implantable pressure relief valve with improved valve stem member
US4781672A (en) * 1986-10-21 1988-11-01 Cordis Corporation Three stage implantable flow control valve with improved valve closure member
EP0276356A1 (en) * 1987-01-29 1988-08-03 Pudenz-Schulte Medical Research Corporation Siphon control device
US4795437A (en) * 1987-01-29 1989-01-03 Pudenz-Schulte Medical Research Corporation Siphon control device
US4921488A (en) * 1988-01-15 1990-05-01 Maitz Carlos A Aspirator device for body fluids
US4861331A (en) * 1988-03-24 1989-08-29 Pudenz-Schulte Medical Research Corp. Implantable shunt system and method of assembly
US4867740A (en) * 1988-03-24 1989-09-19 Pudenz-Schulte Medical Research Corp. Multiple-membrane flow control valve and implantable shunt system
US5024612A (en) * 1988-12-19 1991-06-18 Minnesota Mining And Manufacturing Company External ear canal pressure regulating device and tinnitus suppression device
US5830172A (en) * 1991-04-11 1998-11-03 Leveen; Harry H. Ascites valve
US5342329A (en) * 1991-10-11 1994-08-30 Inmed Ltda. Portable disposable device for post-surgical suction
US5368556A (en) * 1992-01-22 1994-11-29 Cordis Corporation Implantable drainage valve for the treatment of hydrocephalus
US5769093A (en) * 1994-12-09 1998-06-23 Xomed Surgical Products, Inc. Method of relieving synovial fluid pressure
US5807303A (en) * 1994-12-09 1998-09-15 Xomed Surgical Products, Inc. Valve assembly and device for relieving synovial fluid pressure
US9393353B2 (en) 2003-11-20 2016-07-19 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Portable hand pump for evacuation of fluids
US8636721B2 (en) 2003-11-20 2014-01-28 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Portable hand pump for evacuation of fluids
US9907887B2 (en) 2003-11-20 2018-03-06 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Portable hand pump for evacuation of fluids
US20050113766A1 (en) * 2003-11-26 2005-05-26 Jim Mottola Primer bulb for contrast media delivery system
US8337475B2 (en) 2004-10-12 2012-12-25 C. R. Bard, Inc. Corporeal drainage system
US9913935B2 (en) 2004-10-12 2018-03-13 C. R. Bard, Inc. Corporeal drainage system
US9295764B2 (en) 2004-10-12 2016-03-29 C. R. Bard, Inc. Corporeal drainage system
US20060079853A1 (en) * 2004-10-12 2006-04-13 C. R. Bard, Inc. Corporeal drainage system
US20060129111A1 (en) * 2004-12-09 2006-06-15 Mottola Jim D Burette float and drainage aperture
US7731699B2 (en) 2004-12-09 2010-06-08 Merit Medical Systems, Inc. Burette float and drainage aperture
US7879014B2 (en) 2004-12-09 2011-02-01 Merit Medical Systems, Inc. Valve assembly with chamber vent and fluid deflector
US20060264850A1 (en) * 2004-12-09 2006-11-23 Merit Medical Systems, Inc. Valve assembly with chamber vent and fluid deflector
US8740833B2 (en) 2005-04-29 2014-06-03 Medtronic, Inc. Anti-thrombogenic venous shunt method
US8002730B2 (en) * 2005-04-29 2011-08-23 Medtronic, Inc. Anti-thrombogenic venous shunt system and method
US20060258970A1 (en) * 2005-04-29 2006-11-16 Medtronic, Inc. Anti-thrombogenic venous shunt system and method
US8235971B2 (en) 2005-09-26 2012-08-07 C. R. Bard, Inc. Catheter connection systems
US20110009849A1 (en) * 2005-09-26 2011-01-13 C.R. Bard, Inc. Catheter connection systems
US8177772B2 (en) 2005-09-26 2012-05-15 C. R. Bard, Inc. Catheter connection systems
US20070073270A1 (en) * 2005-09-26 2007-03-29 C. R. Bard, Inc. Catheter connection systems
US9861799B2 (en) 2006-04-25 2018-01-09 Medtronic Ps Medical, Inc. Cerebrospinal fluid shunt having long term anti-occlusion agent delivery
US20100042039A1 (en) * 2006-04-25 2010-02-18 Medtronic, Inc. Cerebrospinal fluid shunt having long term anti-occlusion agent delivery
US9694165B2 (en) * 2008-01-28 2017-07-04 Peter Mats Forsell Implantable drainage device
US20150157836A1 (en) * 2008-01-28 2015-06-11 Peter Mats Forsell Implantable drainage device
US8568368B2 (en) 2008-04-14 2013-10-29 Merit Medical Systems, Inc. Contrast media diffusion system
US20090259199A1 (en) * 2008-04-14 2009-10-15 Lampropoulos Fred P Contrast media diffusion system
US20100021860A1 (en) * 2008-07-28 2010-01-28 Stephanie Christman Ergonomic high volme evacuator system
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