WO2009090624A2 - Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo - Google Patents
Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo Download PDFInfo
- Publication number
- WO2009090624A2 WO2009090624A2 PCT/IB2009/050228 IB2009050228W WO2009090624A2 WO 2009090624 A2 WO2009090624 A2 WO 2009090624A2 IB 2009050228 W IB2009050228 W IB 2009050228W WO 2009090624 A2 WO2009090624 A2 WO 2009090624A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- gel
- extract
- chitosan
- alpha
- Prior art date
Links
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 title description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 14
- 241000219295 Portulaca Species 0.000 claims abstract description 14
- 229940101267 panthenol Drugs 0.000 claims abstract description 14
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 14
- 239000011619 pantothenol Substances 0.000 claims abstract description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- 239000003755 preservative agent Substances 0.000 claims description 15
- 239000000499 gel Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 12
- 239000000017 hydrogel Substances 0.000 claims description 10
- 239000004310 lactic acid Substances 0.000 claims description 8
- 235000014655 lactic acid Nutrition 0.000 claims description 8
- 150000007524 organic acids Chemical class 0.000 claims description 7
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 235000015165 citric acid Nutrition 0.000 claims description 6
- 235000012209 glucono delta-lactone Nutrition 0.000 claims description 6
- 229960003681 gluconolactone Drugs 0.000 claims description 6
- 239000004299 sodium benzoate Substances 0.000 claims description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 5
- 229940123208 Biguanide Drugs 0.000 claims description 5
- 229940061720 alpha hydroxy acid Drugs 0.000 claims description 4
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- JKRDADVRIYVCCY-UHFFFAOYSA-N 2-hydroxyoctanoic acid Chemical compound CCCCCCC(O)C(O)=O JKRDADVRIYVCCY-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 229960004275 glycolic acid Drugs 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 239000004227 calcium gluconate Substances 0.000 claims description 2
- 229960004494 calcium gluconate Drugs 0.000 claims description 2
- 235000013927 calcium gluconate Nutrition 0.000 claims description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 2
- 229960003885 sodium benzoate Drugs 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims 3
- 241000717739 Boswellia sacra Species 0.000 claims 2
- 235000003717 Boswellia sacra Nutrition 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 241001057584 Myrrha Species 0.000 claims 1
- 244000270673 Pelargonium graveolens Species 0.000 claims 1
- 235000017927 Pelargonium graveolens Nutrition 0.000 claims 1
- 244000010922 Plantago major Species 0.000 claims 1
- 235000015266 Plantago major Nutrition 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 238000005299 abrasion Methods 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 229940002386 calendula officinalis extract Drugs 0.000 claims 1
- 229940074413 chamaemelum nobile extract Drugs 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 206010053615 Thermal burn Diseases 0.000 abstract description 2
- 230000001681 protective effect Effects 0.000 abstract description 2
- 230000001914 calming effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000887 hydrating effect Effects 0.000 abstract 1
- 238000013532 laser treatment Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 9
- 239000000843 powder Substances 0.000 description 8
- FAPXKQMFIRYKMF-UHFFFAOYSA-N 1-(diaminomethylidene)-2-propylguanidine Chemical compound CCCN=C(N)N=C(N)N FAPXKQMFIRYKMF-UHFFFAOYSA-N 0.000 description 5
- 229920000768 polyamine Polymers 0.000 description 5
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 239000000176 sodium gluconate Substances 0.000 description 3
- 235000012207 sodium gluconate Nutrition 0.000 description 3
- 229940005574 sodium gluconate Drugs 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Definitions
- Chitosan (pol ⁇ - ⁇ -l, 4-D-glucosamine) is a derivative of a natural polysaccharide, known as chitin (poly- ⁇ -l, 4-D-acetylglucosamine) found mainly , in the exoskeleton of crustacean shells.
- biodegradable polymers can be modified and improved through the addition of various substances (chitosan, portulaca, alpha hydroxy acid panthenol and harmless preservatives).
- various substances chitosan, portulaca, alpha hydroxy acid panthenol and harmless preservatives.
- Chitosan gels are obtained by dissolving chitosan in organic acid solutions, mainly of the alpha-hydroxy acid type, such as glycolic acid, lactic acid, alpha hydroxyethanoic acid, alpha hydroxyoctanoic acid, alpha hydroxypric acid, malic acid, citric acid and tartaric acid , which have good water solubility.
- Hydrogels are obtained using chitosan of different ranges of molecular weights between 25,000 and 1,250,000 g / mol and with a degree of deacetylation greater than 80%.
- Figure 1 shows the leg of a person with superficial burns
- Figure 4 shows the area after three days of application of the product, with a frank recovery of damaged tissue, which allows corroborating the therapeutic benefits of the hydrogel:
- the diluted organic acid is added, homogenized and the pH maintained between 4.0 and 4.5, during the manufacture of the hydrogel; subsequently, with continuous stirring, all the chitosan included in the formula is added, slowly, until completely dissolved.
- the preservatives polyamopropyl biguanide, Gluconolactone, Sodium Benzoate and Calcium Gluconate or mixtures of the other preservatives included in this patent and then portulaca or other natural extract and then panthenol are added.
- compositions indicated in this patent are by way of example and do not limit the scope and protection of the invention.
- Viscosity values between 5,000 and 20,000 cps.
- Microbiological absent pathogens and aerobic germs mesophyte, ⁇ . 100 CFU / gram and Fungi and yeasts ⁇ _ 100 CFU / g; Table 1 shows the importance of the inclusion in the compositions of the hydrogels of the mixture of preservatives, in examples 1 to 4, the compositions have minor variations, but the most important thing is that a single preservative is included, In examples 5 to 8, the compositions have minor variations, but the most significant is the inclusion within their components of a mixture of preservatives. From the results of the table it can be seen, already at the second month of study of a significant change in the viscosity, there is a drastic decrease in the formulations of 1 to 4 and an evident microbiological contamination, specifically by fungi. This does not occur in the formulations of examples 5 to 8, which include the mixture of preservatives.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2712527A CA2712527C (en) | 2008-01-18 | 2009-01-21 | Chitosan gel for dermatological use, production method and use of same |
| MX2010007902A MX2010007902A (es) | 2008-01-18 | 2009-01-21 | Gel de quitosano para aplicaciones dermatologicas, proceso de obtencion y uso del mismo. |
| CN200980109724.7A CN101977589B (zh) | 2008-01-18 | 2009-01-21 | 皮肤病学使用的壳聚糖凝胶、其制备方法及其用途 |
| BRPI0906932-1A BRPI0906932A2 (pt) | 2008-01-18 | 2009-01-21 | Gel hidrofílico estável, baseado em um polímero para aplicação tópica, processo para obeter o mesmo e uso do mesmo |
| ES201050012A ES2361459B1 (es) | 2008-01-18 | 2009-01-21 | Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo. |
| JP2010542731A JP5615717B2 (ja) | 2008-01-18 | 2009-01-21 | 皮膚科利用のためのキトサンゲル、その製造方法および使用 |
| EP09702300.6A EP2452673B1 (de) | 2008-01-18 | 2009-01-21 | Chitosan-gel zur dermatologischen anwendung, herstellungsverfahren dafür und seine verwendung |
| US12/863,551 US20100316739A1 (en) | 2008-01-18 | 2009-01-21 | Chitosan gel for dermatological use, production method therefor and use of same |
| EC2010010352A ECSP10010352A (es) | 2008-01-18 | 2010-07-16 | Gel de quitosano para aplicaciones dermatologicas, proceso de obtencion y uso del mismo |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL0156-2008 | 2008-01-18 | ||
| CL200800156A CL2008000156A1 (es) | 2008-01-18 | 2008-01-18 | Gel estable hidrofilo en base a un polimero para aplicacion topica porque comprende quitosano disuelto en un solvente; proceso para obtener el gel para uso topico antes mencionado; uso del gel. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009090624A2 true WO2009090624A2 (es) | 2009-07-23 |
| WO2009090624A3 WO2009090624A3 (es) | 2009-09-11 |
Family
ID=40261146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2009/050228 WO2009090624A2 (es) | 2008-01-18 | 2009-01-21 | Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100316739A1 (de) |
| EP (1) | EP2452673B1 (de) |
| JP (1) | JP5615717B2 (de) |
| CN (1) | CN101977589B (de) |
| AR (1) | AR071334A1 (de) |
| BR (1) | BRPI0906932A2 (de) |
| CA (1) | CA2712527C (de) |
| CL (1) | CL2008000156A1 (de) |
| CO (1) | CO6331421A2 (de) |
| EC (1) | ECSP10010352A (de) |
| ES (1) | ES2361459B1 (de) |
| MX (1) | MX2010007902A (de) |
| PE (1) | PE20091363A1 (de) |
| WO (1) | WO2009090624A2 (de) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103889434B (zh) * | 2011-06-21 | 2017-02-15 | Bvw控股公司 | 含有乳香酸的医疗装置 |
| WO2013112381A2 (en) * | 2012-01-24 | 2013-08-01 | Bvw Holding Ag | New class of anti-adhesion hydrogels with healing aspects |
| RU2526183C1 (ru) * | 2013-02-28 | 2014-08-20 | Федеральное государственное унитарное предприятие Научно-производственный центр "Фармзащита" Федерального медико-биологического агентства (ФГУП НПЦ "Фармзащита" ФМБА России) | Гемостатическая противоожоговая ранозаживляющая композиция |
| JP2017508808A (ja) * | 2014-03-17 | 2017-03-30 | ジー・エフ・エス．コーポレーション．エー・ユー・エス．ピー・ティー・ワイ．エル・ティー・ディーＧｆｓ Ｃｏｒｐｏｒａｔｉｏｎ Ａｕｓ Ｐｔｙ Ｌｔｄ | 抗菌性除菌剤組成物およびその使用 |
| CN103919689A (zh) * | 2014-03-20 | 2014-07-16 | 金红叶纸业集团有限公司 | 湿巾乳液、湿巾及湿巾的制备方法 |
| GB201501333D0 (en) | 2015-01-27 | 2015-03-11 | Medtrade Products Ltd | Composition for a wound dressing |
| GB201501330D0 (en) * | 2015-01-27 | 2015-03-11 | Medtrade Products Ltd | Composition for a wound dressing |
| EA026104B1 (ru) * | 2015-04-02 | 2017-03-31 | Общество С Ограниченной Ответственностью "Тектум" | Кровоостанавливающее и ранозаживляющее средство |
| US10751444B2 (en) | 2015-08-07 | 2020-08-25 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
| US10660945B2 (en) | 2015-08-07 | 2020-05-26 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
| CN105055582B (zh) * | 2015-08-18 | 2018-09-04 | 云南同方科技有限公司 | 一种用于皮肤轻度烧烫伤的配方精油 |
| WO2018005145A1 (en) * | 2016-06-28 | 2018-01-04 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
| JP2020528404A (ja) | 2017-07-19 | 2020-09-24 | ウニベルシダージ ダ ベイラ インテリオール | 皮膚病変の治療における局所適用のためのフィルム、およびそれを得る方法ならびに適用方法 |
| CN108514546B (zh) * | 2018-05-14 | 2020-09-29 | 山东师范大学 | 一种二氢杨梅素的壳聚糖水凝胶制剂及制备方法 |
| CN109731021A (zh) * | 2019-03-20 | 2019-05-10 | 武汉市思泰利医疗器械发展有限公司 | 一种用于治疗修复造口皮肤的壳聚糖水凝胶及其制备方法 |
| US20220211606A1 (en) * | 2019-04-08 | 2022-07-07 | Medoderm Gmbh | Liquid composition for influencing the microbiota on a subject's skin comprising chitosan |
| WO2021007579A1 (en) * | 2019-07-11 | 2021-01-14 | Stenco,Llc | Biodegradable material |
| CN111920742A (zh) * | 2020-09-18 | 2020-11-13 | 微著生物科技(东营)有限责任公司 | 一种壳聚糖多效修复面膜及制备方法 |
| WO2022079142A1 (en) * | 2020-10-14 | 2022-04-21 | Medoderm Gmbh | Liquid composition for use in the prevention or reduction of skin irritation, allergy and/or an infectious disease |
| DE102021109834A1 (de) * | 2021-04-19 | 2022-10-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Zusammensetzung zur Desinfektion und für kosmetische Anwendungen |
| WO2023233299A1 (en) | 2022-05-31 | 2023-12-07 | Instituto Politécnico Da Guarda | Wound dressing comprising a ph sensor composition and method of producing the same |
| US11845859B1 (en) | 2023-03-28 | 2023-12-19 | King Faisal University | Biopolymer derived from algae |
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- 2009-01-16 PE PE2009000057A patent/PE20091363A1/es not_active Application Discontinuation
- 2009-01-21 WO PCT/IB2009/050228 patent/WO2009090624A2/es active Application Filing
- 2009-01-21 MX MX2010007902A patent/MX2010007902A/es active IP Right Grant
- 2009-01-21 EP EP09702300.6A patent/EP2452673B1/de not_active Not-in-force
- 2009-01-21 US US12/863,551 patent/US20100316739A1/en not_active Abandoned
- 2009-01-21 JP JP2010542731A patent/JP5615717B2/ja not_active Expired - Fee Related
- 2009-01-21 CN CN200980109724.7A patent/CN101977589B/zh not_active Expired - Fee Related
- 2009-01-21 BR BRPI0906932-1A patent/BRPI0906932A2/pt not_active IP Right Cessation
- 2009-01-21 CA CA2712527A patent/CA2712527C/en not_active Expired - Fee Related
- 2009-01-21 ES ES201050012A patent/ES2361459B1/es not_active Expired - Fee Related
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| CL2008000156A1 (es) | 2008-08-01 |
| US20100316739A1 (en) | 2010-12-16 |
| AR071334A1 (es) | 2010-06-16 |
| CN101977589A (zh) | 2011-02-16 |
| EP2452673A4 (de) | 2013-04-03 |
| ES2361459A1 (es) | 2011-06-17 |
| EP2452673B1 (de) | 2017-04-26 |
| ES2361459B1 (es) | 2012-04-24 |
| CA2712527C (en) | 2017-02-28 |
| CN101977589B (zh) | 2014-12-10 |
| ES2361459A8 (es) | 2011-07-21 |
| CA2712527A1 (en) | 2009-07-23 |
| ECSP10010352A (es) | 2010-11-30 |
| EP2452673A2 (de) | 2012-05-16 |
| PE20091363A1 (es) | 2009-10-15 |
| WO2009090624A3 (es) | 2009-09-11 |
| BRPI0906932A2 (pt) | 2015-07-28 |
| JP5615717B2 (ja) | 2014-10-29 |
| CO6331421A2 (es) | 2011-10-20 |
| JP2012515710A (ja) | 2012-07-12 |
| MX2010007902A (es) | 2010-11-25 |
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