WO2009078470A1 - 多糖/2本鎖rna複合体 - Google Patents
多糖/2本鎖rna複合体 Download PDFInfo
- Publication number
- WO2009078470A1 WO2009078470A1 PCT/JP2008/073125 JP2008073125W WO2009078470A1 WO 2009078470 A1 WO2009078470 A1 WO 2009078470A1 JP 2008073125 W JP2008073125 W JP 2008073125W WO 2009078470 A1 WO2009078470 A1 WO 2009078470A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- double
- complex
- stranded rna
- stranded
- polysaccharide
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/808,504 US10738304B2 (en) | 2007-12-18 | 2008-12-18 | Complex of polysaccharide and double-stranded RNA |
JP2009546298A JP5354604B2 (ja) | 2007-12-18 | 2008-12-18 | 多糖/2本鎖rna複合体 |
ES08862702.1T ES2566477T3 (es) | 2007-12-18 | 2008-12-18 | Complejo de polisacárido y ARN bicatenario |
CN2008801247235A CN101918554B (zh) | 2007-12-18 | 2008-12-18 | 多糖/双链rna复合物 |
EP08862702.1A EP2226384B1 (en) | 2007-12-18 | 2008-12-18 | Complex of polysaccharide and double-stranded rna |
US16/915,433 US20210054373A1 (en) | 2007-12-18 | 2020-06-29 | Complex of polysaccharide and double-stranded rna and method of inhibiting expression of a target gene in a cell |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-326510 | 2007-12-18 | ||
JP2007326510 | 2007-12-18 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/808,504 A-371-Of-International US10738304B2 (en) | 2007-12-18 | 2008-12-18 | Complex of polysaccharide and double-stranded RNA |
US16/915,433 Continuation US20210054373A1 (en) | 2007-12-18 | 2020-06-29 | Complex of polysaccharide and double-stranded rna and method of inhibiting expression of a target gene in a cell |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009078470A1 true WO2009078470A1 (ja) | 2009-06-25 |
Family
ID=40795583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/073125 WO2009078470A1 (ja) | 2007-12-18 | 2008-12-18 | 多糖/2本鎖rna複合体 |
Country Status (6)
Country | Link |
---|---|
US (2) | US10738304B2 (ja) |
EP (1) | EP2226384B1 (ja) |
JP (1) | JP5354604B2 (ja) |
CN (1) | CN101918554B (ja) |
ES (1) | ES2566477T3 (ja) |
WO (1) | WO2009078470A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012020795A1 (ja) * | 2010-08-10 | 2012-02-16 | ナパジェン ファーマ,インコーポレテッド | 核酸多糖複合体 |
WO2012117855A1 (ja) | 2011-02-28 | 2012-09-07 | ナパジェン ファーマ,インコーポレテッド | 核酸多糖複合体 |
WO2013021784A1 (ja) | 2011-08-10 | 2013-02-14 | ナパジェン ファーマ,インコーポレテッド | 免疫寛容誘導剤 |
WO2013191223A1 (ja) * | 2012-06-20 | 2013-12-27 | 独立行政法人科学技術振興機構 | 核酸複合体および核酸多糖複合体 |
WO2017217531A1 (ja) * | 2016-06-16 | 2017-12-21 | ナパジェン ファーマ,インコーポレテッド | 核酸と抗原ペプチドの結合体 |
WO2018097296A1 (ja) | 2016-11-28 | 2018-05-31 | ナパジェン ファーマ,インコーポレテッド | 化学修飾siRNA |
WO2019230898A1 (ja) | 2018-05-30 | 2019-12-05 | ナパジェン ファーマ,インコーポレテッド | 化学修飾siRNAとシゾフィランとの複合体を含む医薬組成物 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9566346B2 (en) | 2013-02-05 | 2017-02-14 | B.G. Negev Technologies And Applications Ltd. | Positively charged polysaccharides for RNA transfection |
CN107630015B (zh) * | 2016-07-19 | 2021-03-09 | 上海市东方医院 | 一种稳定的dna-rna双链结构 |
CN110951723B (zh) * | 2019-12-06 | 2023-12-12 | 天津大学 | 一种纯dna双链缠结水凝胶及制备方法及应用 |
CN113045682B (zh) * | 2021-03-11 | 2022-06-21 | 内蒙古大学 | 一种阳离子多糖及其制备方法与应用 |
WO2024055011A1 (en) * | 2022-09-08 | 2024-03-14 | Team Medical, Llc | Material compositions and methods of use improving rna stability |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996014873A2 (en) | 1994-11-16 | 1996-05-23 | Sri International | COVALENTLY BOUND β-GLUCAN CONJUGATES IN TARGETED DELIVERY |
WO2001034207A1 (fr) | 1999-11-10 | 2001-05-17 | Japan Science And Technology Corporation | Supports de genes |
JP2004261024A (ja) * | 2003-02-28 | 2004-09-24 | Japan Science & Technology Agency | ペプチド修飾多糖類を用いる遺伝子治療剤 |
JP2005204612A (ja) | 2004-01-26 | 2005-08-04 | Japan Science & Technology Agency | 新規な遺伝子導入法 |
JP2005255750A (ja) * | 2004-03-10 | 2005-09-22 | Japan Science & Technology Agency | ポリエチレングリコールまたはポリプロピレングリコール修飾β−1,3−グルカン系遺伝子キャリアー |
JP2006069913A (ja) | 2004-08-31 | 2006-03-16 | Japan Science & Technology Agency | ハイブリッド多糖系キャリアーを用いる核酸類の導入方法。 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080066987A (ko) | 2005-11-04 | 2008-07-17 | 나스텍 파마수티컬 컴퍼니 인코포레이티드 | siRNA에 대한 전달 운반체로서의 펩티드-다이서 기질RNA 접합체들 |
CA2633063A1 (en) | 2005-12-16 | 2007-06-21 | Diatos | Cell penetrating peptide conjugates for delivering of nucleic acids intocells |
-
2008
- 2008-12-18 JP JP2009546298A patent/JP5354604B2/ja active Active
- 2008-12-18 CN CN2008801247235A patent/CN101918554B/zh active Active
- 2008-12-18 ES ES08862702.1T patent/ES2566477T3/es active Active
- 2008-12-18 EP EP08862702.1A patent/EP2226384B1/en active Active
- 2008-12-18 US US12/808,504 patent/US10738304B2/en active Active
- 2008-12-18 WO PCT/JP2008/073125 patent/WO2009078470A1/ja active Application Filing
-
2020
- 2020-06-29 US US16/915,433 patent/US20210054373A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1996014873A2 (en) | 1994-11-16 | 1996-05-23 | Sri International | COVALENTLY BOUND β-GLUCAN CONJUGATES IN TARGETED DELIVERY |
WO2001034207A1 (fr) | 1999-11-10 | 2001-05-17 | Japan Science And Technology Corporation | Supports de genes |
JP2004261024A (ja) * | 2003-02-28 | 2004-09-24 | Japan Science & Technology Agency | ペプチド修飾多糖類を用いる遺伝子治療剤 |
JP2005204612A (ja) | 2004-01-26 | 2005-08-04 | Japan Science & Technology Agency | 新規な遺伝子導入法 |
JP2005255750A (ja) * | 2004-03-10 | 2005-09-22 | Japan Science & Technology Agency | ポリエチレングリコールまたはポリプロピレングリコール修飾β−1,3−グルカン系遺伝子キャリアー |
JP2006069913A (ja) | 2004-08-31 | 2006-03-16 | Japan Science & Technology Agency | ハイブリッド多糖系キャリアーを用いる核酸類の導入方法。 |
Non-Patent Citations (14)
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A.C.S., vol. 38, no. 1, 1997, pages 253 |
CARBOHYDRATE RESEARCH, vol. 89, 1981, pages 121 - 135 |
HASEGAWA, ONCOLOGY AND CHEMOTHERAPY, vol. 8, 1992, pages 225 |
J. ROSSI ET AL., NATURE BIOTECH., vol. 23, 2005, pages 222 - 226 |
KAZUO SAKURAI, POLYM. PREPRINTS, JPN., vol. 49, 2000, pages 4054 |
KAZUO SAKURAI, POLYM. PREPRINTS. JPN., vol. 49, 2000, pages 4054 |
MATSUMOTO TAKAHIRO ET AL., BIOCHIM BIOPHYS ACTA, vol. 1670, no. 2, 2004, pages 91 - 104 |
NAGASAKI TAKESHI ET AL., BIOCONJUGATE CHEMISTRY, vol. 15, 2004, pages 249 - 259 |
RYOUJI KARINAGA, BIOMATERIALS, vol. 26, no. 23, August 2005 (2005-08-01), pages 4866 - 73 |
See also references of EP2226384A4 * |
TAKAHISA ANADA ET AL., JOURNAL OF CONTROLLED RELEASE, vol. 108, no. 2-3, 28 November 2005 (2005-11-28), pages 529 - 539 |
THERESA M. ET AL., J. AM. CHEM. SOC., vol. 120, 1998, pages 6909 |
UI-TEI ET AL., NUCLEIC ACIDS RES., vol. 32, 2004, pages 936 - 948 |
WILLMENT J. A. ET AL.: "Charactarization of the Human beta-Glucan Receptor and Its Alternatively Spliced Isoforms", J. BIOL. CHEM., vol. 276, no. 47, 2001, pages 43818 - 43823 * |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2012020795A1 (ja) * | 2010-08-10 | 2013-10-28 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 核酸多糖複合体 |
WO2012020795A1 (ja) * | 2010-08-10 | 2012-02-16 | ナパジェン ファーマ,インコーポレテッド | 核酸多糖複合体 |
US9713636B2 (en) | 2011-02-28 | 2017-07-25 | Napajen Pharma, Inc. | Nucleic acid/polysaccharide complex |
JP6124785B2 (ja) * | 2011-02-28 | 2017-05-10 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 核酸多糖複合体 |
US9801929B2 (en) | 2011-02-28 | 2017-10-31 | Napajen Pharma, Inc. | Immune tolerance inducer |
JPWO2012117855A1 (ja) * | 2011-02-28 | 2014-07-07 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 核酸多糖複合体 |
WO2012117855A1 (ja) | 2011-02-28 | 2012-09-07 | ナパジェン ファーマ,インコーポレテッド | 核酸多糖複合体 |
JPWO2013021784A1 (ja) * | 2011-08-10 | 2015-03-05 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 免疫寛容誘導剤 |
WO2013021784A1 (ja) | 2011-08-10 | 2013-02-14 | ナパジェン ファーマ,インコーポレテッド | 免疫寛容誘導剤 |
CN104471063A (zh) * | 2012-06-20 | 2015-03-25 | 独立行政法人科学技术振兴机构 | 核酸复合物及核酸多糖复合物 |
JPWO2013191223A1 (ja) * | 2012-06-20 | 2016-05-26 | 国立研究開発法人科学技術振興機構 | 核酸複合体および核酸多糖複合体 |
WO2013191223A1 (ja) * | 2012-06-20 | 2013-12-27 | 独立行政法人科学技術振興機構 | 核酸複合体および核酸多糖複合体 |
WO2017217531A1 (ja) * | 2016-06-16 | 2017-12-21 | ナパジェン ファーマ,インコーポレテッド | 核酸と抗原ペプチドの結合体 |
JPWO2017217531A1 (ja) * | 2016-06-16 | 2019-04-04 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 核酸と抗原ペプチドの結合体 |
WO2018097296A1 (ja) | 2016-11-28 | 2018-05-31 | ナパジェン ファーマ,インコーポレテッド | 化学修飾siRNA |
JPWO2018097296A1 (ja) * | 2016-11-28 | 2018-11-29 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 化学修飾siRNA |
JP2019089820A (ja) * | 2016-11-28 | 2019-06-13 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 化学修飾siRNA |
US11203755B2 (en) | 2016-11-28 | 2021-12-21 | Napajen Pharma, Inc. | Chemically-modified siRNA |
JP7100367B2 (ja) | 2016-11-28 | 2022-07-13 | ナパジェン ファーマ,インコーポレテッド | 化学修飾siRNA |
WO2019230898A1 (ja) | 2018-05-30 | 2019-12-05 | ナパジェン ファーマ,インコーポレテッド | 化学修飾siRNAとシゾフィランとの複合体を含む医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
US10738304B2 (en) | 2020-08-11 |
US20210054373A1 (en) | 2021-02-25 |
JP5354604B2 (ja) | 2013-11-27 |
CN101918554A (zh) | 2010-12-15 |
EP2226384B1 (en) | 2016-03-02 |
US20110111501A1 (en) | 2011-05-12 |
EP2226384A4 (en) | 2011-03-30 |
ES2566477T3 (es) | 2016-04-13 |
EP2226384A1 (en) | 2010-09-08 |
CN101918554B (zh) | 2013-07-03 |
JPWO2009078470A1 (ja) | 2011-04-28 |
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