WO2009075346A1 - 走査型レーザ顕微鏡 - Google Patents

走査型レーザ顕微鏡 Download PDF

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Publication number
WO2009075346A1
WO2009075346A1 PCT/JP2008/072611 JP2008072611W WO2009075346A1 WO 2009075346 A1 WO2009075346 A1 WO 2009075346A1 JP 2008072611 W JP2008072611 W JP 2008072611W WO 2009075346 A1 WO2009075346 A1 WO 2009075346A1
Authority
WO
WIPO (PCT)
Prior art keywords
scanning
line
time required
laser microscope
microscope
Prior art date
Application number
PCT/JP2008/072611
Other languages
English (en)
French (fr)
Inventor
Hiroshi Kishimoto
Original Assignee
Nikon Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikon Corporation filed Critical Nikon Corporation
Priority to EP08858605A priority Critical patent/EP2237097A4/en
Priority to JP2009545455A priority patent/JP5083325B2/ja
Publication of WO2009075346A1 publication Critical patent/WO2009075346A1/ja
Priority to US12/814,166 priority patent/US8194311B2/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
    • G02B26/10—Scanning systems
    • G02B26/105—Scanning systems with one or more pivoting mirrors or galvano-mirrors

Landscapes

  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Multimedia (AREA)
  • General Engineering & Computer Science (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

本発明は、任意のフレームレートで画像を取得することができる走査型レーザ顕微鏡に関する。 コントローラ６１は、設定されたフレームレートから求められる１フレームの走査に必要な時間に基づいて、１ラインの走査に用いられる時間として要求される要求ライン走査時間を算出し、レーザ光を１ラインずつスキャンさせる走査手段を駆動する駆動波形データの１ライン分のデータ数、および、駆動波形データの読み出し周期のうちの少なくともいずれか一方を調整して、スキャナ１４Ｘがレーザ光を１ライン走査する時間を、要求ライン走査時間に略一致させる。本発明は、例えば、共焦点レーザ走査型顕微鏡に適用できる。
PCT/JP2008/072611 2007-12-13 2008-12-12 走査型レーザ顕微鏡 WO2009075346A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08858605A EP2237097A4 (en) 2007-12-13 2008-12-12 SCANNING LASER MICROSCOPE
JP2009545455A JP5083325B2 (ja) 2007-12-13 2008-12-12 走査型レーザ顕微鏡
US12/814,166 US8194311B2 (en) 2007-12-13 2010-06-11 Scanning laser microscope

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-322064 2007-12-13
JP2007322064 2007-12-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/814,166 Continuation US8194311B2 (en) 2007-12-13 2010-06-11 Scanning laser microscope

Publications (1)

Publication Number Publication Date
WO2009075346A1 true WO2009075346A1 (ja) 2009-06-18

Family

ID=40755582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072611 WO2009075346A1 (ja) 2007-12-13 2008-12-12 走査型レーザ顕微鏡

Country Status (4)

Country Link
US (1) US8194311B2 (ja)
EP (1) EP2237097A4 (ja)
JP (1) JP5083325B2 (ja)
WO (1) WO2009075346A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011112780A (ja) * 2009-11-25 2011-06-09 Olympus Corp 走査型顕微鏡
WO2012002893A1 (en) * 2010-06-30 2012-01-05 Ge Healthcare Bio-Sciences Corp A system for synchronization in a line scanning imaging microscope

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103698880B (zh) * 2013-12-26 2016-01-27 中国科学院苏州生物医学工程技术研究所 激光扫描共聚焦显微镜用二维针孔电动实时调整系统
US20180267284A1 (en) * 2015-01-31 2018-09-20 Board Of Regents, The University Of Texas System High-speed laser scanning microscopy platform for high-throughput automated 3d imaging and functional volumetric imaging

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003098468A (ja) 2001-09-20 2003-04-03 Nikon Corp スキャナ装置およびそれを備えたコンフォーカル顕微鏡
JP2003177323A (ja) * 2001-12-11 2003-06-27 Olympus Optical Co Ltd 走査型レーザ顕微鏡、駆動波形データ生成方法、及びその制御プログラム
JP2005352030A (ja) * 2004-06-09 2005-12-22 Olympus Corp 走査型レーザ観察装置、観察方法及び観察プログラム
JP2006145857A (ja) * 2004-11-19 2006-06-08 Olympus Corp 走査型レーザ顕微鏡
JP2006195440A (ja) * 2004-12-13 2006-07-27 Olympus Corp 走査型レーザ顕微鏡装置
JP2006227600A (ja) * 2005-01-18 2006-08-31 Olympus Corp 走査型顕微鏡および標本画像取得方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7852551B2 (en) * 2004-06-14 2010-12-14 Olympus Corporation Optical-scanning microscope examination apparatus
DE102004034951A1 (de) * 2004-07-16 2006-02-02 Carl Zeiss Jena Gmbh Verfahren zur bildlichen Erfassung von Objekten mittels eines Lichtrastermikrokopes mit linienförmiger Abtastung
JP2006119347A (ja) * 2004-10-21 2006-05-11 Olympus Corp レーザ走査型顕微鏡
US7696996B2 (en) * 2004-12-13 2010-04-13 Olympus Corporation Laser scanning microscope apparatus
US7612350B2 (en) * 2005-01-18 2009-11-03 Olympus Corporation Scanning microscope and specimen image obtaining method in which adjacent data obtaining points are not consecutively obtained

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003098468A (ja) 2001-09-20 2003-04-03 Nikon Corp スキャナ装置およびそれを備えたコンフォーカル顕微鏡
JP2003177323A (ja) * 2001-12-11 2003-06-27 Olympus Optical Co Ltd 走査型レーザ顕微鏡、駆動波形データ生成方法、及びその制御プログラム
JP2005352030A (ja) * 2004-06-09 2005-12-22 Olympus Corp 走査型レーザ観察装置、観察方法及び観察プログラム
JP2006145857A (ja) * 2004-11-19 2006-06-08 Olympus Corp 走査型レーザ顕微鏡
JP2006195440A (ja) * 2004-12-13 2006-07-27 Olympus Corp 走査型レーザ顕微鏡装置
JP2006227600A (ja) * 2005-01-18 2006-08-31 Olympus Corp 走査型顕微鏡および標本画像取得方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011112780A (ja) * 2009-11-25 2011-06-09 Olympus Corp 走査型顕微鏡
WO2012002893A1 (en) * 2010-06-30 2012-01-05 Ge Healthcare Bio-Sciences Corp A system for synchronization in a line scanning imaging microscope
JP2013531819A (ja) * 2010-06-30 2013-08-08 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション ライン走査式顕微鏡における同期用システム
US10027855B2 (en) 2010-06-30 2018-07-17 Ge Healthcare Bio-Science Corp. System for synchronization in a line scanning imaging microscope

Also Published As

Publication number Publication date
EP2237097A4 (en) 2013-02-27
JP5083325B2 (ja) 2012-11-28
EP2237097A1 (en) 2010-10-06
US20100245994A1 (en) 2010-09-30
JPWO2009075346A1 (ja) 2011-04-28
US8194311B2 (en) 2012-06-05

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