WO2009068214A3 - Heteroaryl-substituierte piperidine - Google Patents

Heteroaryl-substituierte piperidine Download PDF

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Publication number
WO2009068214A3
WO2009068214A3 PCT/EP2008/009792 EP2008009792W WO2009068214A3 WO 2009068214 A3 WO2009068214 A3 WO 2009068214A3 EP 2008009792 W EP2008009792 W EP 2008009792W WO 2009068214 A3 WO2009068214 A3 WO 2009068214A3
Authority
WO
WIPO (PCT)
Prior art keywords
heteroaryl
substituted piperidines
diseases
prophylaxis
treatment
Prior art date
Application number
PCT/EP2008/009792
Other languages
English (en)
French (fr)
Other versions
WO2009068214A2 (de
Inventor
Dirk Heimbach
Susanne Roehrig
Dirk Schneider
Ulrich Rester
Eckhard Bender
Mark Meininghaus
Katja Zimmermann
Dimitry Zubov
Anja Buchmueller
Georges Degenfeld
Christoph Gerdes
Michael Gerisch
Mark Jean Gnoth
Yolanda Cancho-Grande
Kersten Matthias Gericke
Mario Jeske
Original Assignee
Bayer Schering Pharma Ag
Dirk Heimbach
Susanne Roehrig
Dirk Schneider
Ulrich Rester
Eckhard Bender
Mark Meininghaus
Katja Zimmermann
Dimitry Zubov
Anja Buchmueller
Georges Degenfeld
Christoph Gerdes
Michael Gerisch
Mark Jean Gnoth
Yolanda Cancho-Grande
Kersten Matthias Gericke
Mario Jeske
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102007057718A external-priority patent/DE102007057718A1/de
Priority claimed from DE102008010221A external-priority patent/DE102008010221A1/de
Priority to EP08854224A priority Critical patent/EP2227466B1/de
Priority to PL08854224T priority patent/PL2227466T3/pl
Priority to DE502008003324T priority patent/DE502008003324D1/de
Priority to JP2010535272A priority patent/JP5450435B2/ja
Application filed by Bayer Schering Pharma Ag, Dirk Heimbach, Susanne Roehrig, Dirk Schneider, Ulrich Rester, Eckhard Bender, Mark Meininghaus, Katja Zimmermann, Dimitry Zubov, Anja Buchmueller, Georges Degenfeld, Christoph Gerdes, Michael Gerisch, Mark Jean Gnoth, Yolanda Cancho-Grande, Kersten Matthias Gericke, Mario Jeske filed Critical Bayer Schering Pharma Ag
Priority to CN2008801260263A priority patent/CN101932577B/zh
Priority to DK08854224.6T priority patent/DK2227466T3/da
Priority to AT08854224T priority patent/ATE506359T1/de
Priority to CA2706991A priority patent/CA2706991A1/en
Publication of WO2009068214A2 publication Critical patent/WO2009068214A2/de
Publication of WO2009068214A3 publication Critical patent/WO2009068214A3/de
Priority to HK11106516.9A priority patent/HK1152311A1/xx
Priority to HR20110510T priority patent/HRP20110510T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Die Erfindung betrifft neue Heteroaryl-substituierte Piperidine, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere von Herz-Kreislauf-Erkrankungen und von Tumorerkrankungen.
PCT/EP2008/009792 2007-11-30 2008-11-20 Heteroaryl-substituierte piperidine WO2009068214A2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA2706991A CA2706991A1 (en) 2007-11-30 2008-11-20 Heteroaryl-substituted piperidines
AT08854224T ATE506359T1 (de) 2007-11-30 2008-11-20 Heteroaryl-substituierte piperidine
PL08854224T PL2227466T3 (pl) 2007-11-30 2008-11-20 Piperydyny podstawione heteroarylem
DE502008003324T DE502008003324D1 (de) 2007-11-30 2008-11-20 Heteroaryl-substituierte piperidine
JP2010535272A JP5450435B2 (ja) 2007-11-30 2008-11-20 ヘテロアリールで置換されたピペリジン類
EP08854224A EP2227466B1 (de) 2007-11-30 2008-11-20 Heteroaryl-substituierte piperidine
CN2008801260263A CN101932577B (zh) 2007-11-30 2008-11-20 杂芳基取代的哌啶
DK08854224.6T DK2227466T3 (da) 2007-11-30 2008-11-20 Heteroaryl-substituerede piperidiner
HK11106516.9A HK1152311A1 (en) 2007-11-30 2011-06-23 Heteroaryl-substituted piperidines
HR20110510T HRP20110510T1 (hr) 2007-11-30 2011-07-07 Heteroaril-supstituirani piperidini

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102007057718A DE102007057718A1 (de) 2007-11-30 2007-11-30 Heteroaryl-substituierte Piperidine
DE102007057718.6 2007-11-30
DE102008010221.0 2008-02-20
DE102008010221A DE102008010221A1 (de) 2008-02-20 2008-02-20 Heteroaryl-substituierte Piperidine

Publications (2)

Publication Number Publication Date
WO2009068214A2 WO2009068214A2 (de) 2009-06-04
WO2009068214A3 true WO2009068214A3 (de) 2009-08-20

Family

ID=40580130

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/009792 WO2009068214A2 (de) 2007-11-30 2008-11-20 Heteroaryl-substituierte piperidine

Country Status (20)

Country Link
US (2) US8119663B2 (de)
EP (1) EP2227466B1 (de)
JP (1) JP5450435B2 (de)
KR (1) KR20100114018A (de)
CN (1) CN101932577B (de)
AR (1) AR069417A1 (de)
AT (1) ATE506359T1 (de)
CA (1) CA2706991A1 (de)
CL (1) CL2008003473A1 (de)
DE (1) DE502008003324D1 (de)
DK (1) DK2227466T3 (de)
HK (1) HK1152311A1 (de)
HR (1) HRP20110510T1 (de)
PA (1) PA8805201A1 (de)
PE (1) PE20091026A1 (de)
PL (1) PL2227466T3 (de)
PT (1) PT2227466E (de)
TW (1) TW200936135A (de)
UY (1) UY31484A1 (de)
WO (1) WO2009068214A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009014484A1 (de) 2009-03-23 2010-09-30 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022896A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022897A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022894A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022895A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
US20130190506A1 (en) * 2010-06-28 2013-07-25 Hetero Research Foundation Process for olmesartan medoxomil
KR20130043207A (ko) 2010-07-22 2013-04-29 자프겐 인크. 트리시클릭 화합물 및 이의 제조 및 사용 방법
US9221787B2 (en) 2010-10-12 2015-12-29 Zafgen, Inc. Sulphonamine compounds and methods of making and using same
TW201300380A (zh) * 2010-10-19 2013-01-01 Comentis Inc 抑制β－分泌酶活性之噁二唑化合物及其使用方法
MX344238B (es) 2011-01-26 2016-12-07 Zafgen Inc Compuestos de tetrazol y métodos para preparar y usar los mismos.
WO2012154678A1 (en) 2011-05-06 2012-11-15 Zafgen Corporation Tricyclic sulfonamide compounds and methods of making and using same
BR112013028534A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos
AU2012253760B2 (en) 2011-05-06 2016-02-04 Zafgen, Inc. Tricyclic pyrazole sulfonamide compounds and methods of making and using same
US9440943B2 (en) 2012-01-18 2016-09-13 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
AU2013209723B2 (en) 2012-01-18 2016-11-24 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
NZ707773A (en) 2012-11-05 2019-05-31 Zafgen Inc Methods of treating liver diseases
MX2015005733A (es) 2012-11-05 2016-02-10 Zafgen Inc Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad.
AU2013337282A1 (en) 2012-11-05 2015-05-21 Zafgen, Inc. Tricyclic compounds and methods of making and using same
CN103965095A (zh) * 2013-02-04 2014-08-06 艾琪康医药科技（上海）有限公司 1-r1-3-r2-4-氟哌啶及其衍生物的制备方法
CN104341590A (zh) * 2013-08-01 2015-02-11 韩冰 一种树枝状高分子化合物及其制备和用途
EP3936192A4 (de) 2019-03-06 2022-11-16 Daiichi Sankyo Company, Limited Pyrrolopyrazolderivate

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Also Published As

Publication number Publication date
WO2009068214A2 (de) 2009-06-04
PA8805201A1 (es) 2010-02-12
JP2011504889A (ja) 2011-02-17
CN101932577B (zh) 2013-07-17
US20120214788A1 (en) 2012-08-23
HRP20110510T1 (hr) 2011-08-31
CN101932577A (zh) 2010-12-29
PE20091026A1 (es) 2009-07-26
ATE506359T1 (de) 2011-05-15
EP2227466A2 (de) 2010-09-15
UY31484A1 (es) 2009-07-17
TW200936135A (en) 2009-09-01
DE502008003324D1 (de) 2011-06-01
HK1152311A1 (en) 2012-02-24
PL2227466T3 (pl) 2011-09-30
US8119663B2 (en) 2012-02-21
CL2008003473A1 (es) 2009-08-14
PT2227466E (pt) 2011-07-01
DK2227466T3 (da) 2011-08-08
EP2227466B1 (de) 2011-04-20
JP5450435B2 (ja) 2014-03-26
AR069417A1 (es) 2010-01-20
US20090306139A1 (en) 2009-12-10
CA2706991A1 (en) 2009-06-04
KR20100114018A (ko) 2010-10-22

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