WO2009057802A1 - β-1,3-グルカン由来ポリアルデヒド／ポリアミンハイドロゲル - Google Patents

β-1,3-グルカン由来ポリアルデヒド／ポリアミンハイドロゲル Download PDF

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Publication number
WO2009057802A1
WO2009057802A1 PCT/JP2008/070052 JP2008070052W WO2009057802A1 WO 2009057802 A1 WO2009057802 A1 WO 2009057802A1 JP 2008070052 W JP2008070052 W JP 2008070052W WO 2009057802 A1 WO2009057802 A1 WO 2009057802A1
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WO
WIPO (PCT)
Prior art keywords
polyaldehyde
glucan
derived
polyamine
combination
Prior art date
Application number
PCT/JP2008/070052
Other languages
English (en)
French (fr)
Inventor
Takeshi Nagasaki
Tatsuro Hayashi
Kenji Oohata
Kenichi Ishibashi
Toshio Suzuki
Yoshiro Furukawa
Original Assignee
Osaka City University
Daiso Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osaka City University, Daiso Co., Ltd. filed Critical Osaka City University
Priority to JP2009539157A priority Critical patent/JP5660781B2/ja
Priority to EP08846114A priority patent/EP2210917A1/en
Priority to US12/734,425 priority patent/US8246992B2/en
Publication of WO2009057802A1 publication Critical patent/WO2009057802A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/04—Polyamides derived from alpha-amino carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

　（１）β-1,3-グルカンの側鎖グルコースにアルデヒド基を導入したポリアルデヒド、および、（２）ポリ-L-リジンを高分子量化したポリアミン、を含む組合せ物を提供する。本発明の組合せ物は、ウイルスなどの感染症の危険性が低く、生分解性・生体適合性を有し、安全性が高く、接着速度・強度に優れた、止血剤等として利用できる組織接着性ハイドロゲルの材料として有用である。
PCT/JP2008/070052 2007-11-01 2008-11-04 β-1,3-グルカン由来ポリアルデヒド／ポリアミンハイドロゲル WO2009057802A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009539157A JP5660781B2 (ja) 2007-11-01 2008-11-04 β−１，３−グルカン由来ポリアルデヒド／ポリアミンハイドロゲル
EP08846114A EP2210917A1 (en) 2007-11-01 2008-11-04 -1,3-glucan-derived polyaldehyde/polyamine hydrogel
US12/734,425 US8246992B2 (en) 2007-11-01 2008-11-04 β-1,3-glucan-derived polyaldehyde/polyamine hydrogel

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-285087 2007-11-01
JP2007285087 2007-11-01
JP2008-180178 2008-07-10
JP2008180178 2008-07-10

Publications (1)

Publication Number Publication Date
WO2009057802A1 true WO2009057802A1 (ja) 2009-05-07

Family

ID=40591179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/070052 WO2009057802A1 (ja) 2007-11-01 2008-11-04 β-1,3-グルカン由来ポリアルデヒド／ポリアミンハイドロゲル

Country Status (4)

Country Link
US (1) US8246992B2 (ja)
EP (1) EP2210917A1 (ja)
JP (1) JP5660781B2 (ja)
WO (1) WO2009057802A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013514093A (ja) * 2009-12-16 2013-04-25 バクスター・インターナショナル・インコーポレイテッド 止血スポンジ
WO2013176239A1 (ja) * 2012-05-24 2013-11-28 国立大学法人 東京大学 酸化オリゴ糖で架橋したゲル材料
JP2013544817A (ja) * 2010-11-29 2013-12-19 ビオテック ファルマコン アルメン アクスイェ セルスカプ グルカン組成物
JP2014513737A (ja) * 2011-04-20 2014-06-05 スフィリテック・リミテッド 架橋ポリ−ε−リシン粒子
JP2017525780A (ja) * 2014-05-20 2017-09-07 ナフ インサレーション， インコーポレイテッド 結合剤
US11951229B2 (en) 2020-08-20 2024-04-09 Aobakasei Kabushiki Kaisha Liquid hemostatic medical material

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GB2562004B (en) * 2012-04-20 2019-10-23 Spheritech Ltd Cross-linked poly-e-lysine particles
CN103316330B (zh) * 2012-06-28 2016-03-09 西藏贝珠雅药业有限公司 一种软组织创伤护理材料的组方与用途
KR101846271B1 (ko) * 2015-11-13 2018-04-06 서강대학교산학협력단 유착 방지용 하이드로젤 및 이의 제조 방법
RU2746504C1 (ru) * 2020-02-27 2021-04-14 Ниармедик Интернэшнл Лимитед Противомикробные средства на основе бета-глюканов, способы их получения и применения
CN114452436B (zh) * 2022-03-15 2022-08-23 四川大学 一种胶原基可注射自修复水凝胶及其制备方法
CN115154646B (zh) * 2022-06-20 2023-12-01 国科温州研究院(温州生物材料与工程研究所) 一种可降解止血微球及制备方法与应用
CN115449534B (zh) * 2022-10-09 2023-05-16 浙江大学舟山海洋研究中心 一种马尾藻和鱼糜废水的混合酶解方法
CN115554462B (zh) * 2022-10-31 2023-09-22 西安交通大学 一种抗溶胀的可注射水凝胶粘接剂及其制备方法

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013514093A (ja) * 2009-12-16 2013-04-25 バクスター・インターナショナル・インコーポレイテッド 止血スポンジ
JP2013544817A (ja) * 2010-11-29 2013-12-19 ビオテック ファルマコン アルメン アクスイェ セルスカプ グルカン組成物
JP2014513737A (ja) * 2011-04-20 2014-06-05 スフィリテック・リミテッド 架橋ポリ−ε−リシン粒子
US9938378B2 (en) 2011-04-20 2018-04-10 Spheritech Ltd Cross-linked poly-E-lysine non-particulate support
US10266652B2 (en) 2011-04-20 2019-04-23 Spheritech Ltd. Cross-linked poly-E-lysine non-particulate support
WO2013176239A1 (ja) * 2012-05-24 2013-11-28 国立大学法人 東京大学 酸化オリゴ糖で架橋したゲル材料
JPWO2013176239A1 (ja) * 2012-05-24 2016-01-14 国立大学法人 東京大学 酸化オリゴ糖で架橋したゲル材料
JP2017525780A (ja) * 2014-05-20 2017-09-07 ナフ インサレーション， インコーポレイテッド 結合剤
US11951229B2 (en) 2020-08-20 2024-04-09 Aobakasei Kabushiki Kaisha Liquid hemostatic medical material

Also Published As

Publication number Publication date
US20100316719A1 (en) 2010-12-16
JPWO2009057802A1 (ja) 2011-03-17
EP2210917A1 (en) 2010-07-28
JP5660781B2 (ja) 2015-01-28
US8246992B2 (en) 2012-08-21

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