WO2009057578A1 - 新規アミロイド親和性化合物の使用及び製造方法 - Google Patents

新規アミロイド親和性化合物の使用及び製造方法 Download PDF

Info

Publication number
WO2009057578A1
WO2009057578A1 PCT/JP2008/069504 JP2008069504W WO2009057578A1 WO 2009057578 A1 WO2009057578 A1 WO 2009057578A1 JP 2008069504 W JP2008069504 W JP 2008069504W WO 2009057578 A1 WO2009057578 A1 WO 2009057578A1
Authority
WO
WIPO (PCT)
Prior art keywords
amyloids
utilization
producing
same
novel compounds
Prior art date
Application number
PCT/JP2008/069504
Other languages
English (en)
French (fr)
Inventor
Shigeyuki Tanifuji
Daisaku Nakamura
Shinya Takasaki
Yuki Okumura
Original Assignee
Nihon Medi-Physics Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi-Physics Co., Ltd. filed Critical Nihon Medi-Physics Co., Ltd.
Priority to CA2704139A priority Critical patent/CA2704139A1/en
Priority to EP08843543A priority patent/EP2216050A4/en
Priority to JP2009539060A priority patent/JPWO2009057578A1/ja
Priority to AU2008319987A priority patent/AU2008319987A1/en
Priority to CN2008801234466A priority patent/CN101909659A/zh
Priority to US12/740,658 priority patent/US20100249419A1/en
Publication of WO2009057578A1 publication Critical patent/WO2009057578A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

アミロイドへの親和性を有し、かつ、変異原性等の毒性がおさえられた化合物を用いて、インビトロ（ｉｎ ｖｉｔｒｏ）及びインビボ（ｉｎ ｖｉｖｏ）でアミロイドを高感度に検出し得る、生体組織中のアミロイドの検出試薬を提供する。 下記式（１）で表される化合物またはその塩を含有してなる、生体組織に沈着したアミロイドの検出試薬。 （式中、Ａ１、Ａ２、Ａ３及びＡ４はそれぞれ独立に炭素又は窒素、Ｒ１は放射性ハロゲン置換基、Ｒ２は水素、水酸基、メトキシ基、カルボキシル基、アミノ基、Ｎ−メチルアミノ基、Ｎ，Ｎ−ジメチルアミノ基及びシアノ 基からなる群より選ばれる基、ｍは０～２の整数である。ただし、Ａ１、Ａ２、Ａ３及びＡ４のうちの少なくと も一つは炭素であって、Ｒ１は、炭素であるＡ１、Ａ２、Ａ３及びＡ４に結合する。）
PCT/JP2008/069504 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法 WO2009057578A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2704139A CA2704139A1 (en) 2007-10-30 2008-10-28 Utilization of novel compounds with amyloid affinity and method of producing the same
EP08843543A EP2216050A4 (en) 2007-10-30 2008-10-28 USE OF NEW COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF MANUFACTURING THEREOF
JP2009539060A JPWO2009057578A1 (ja) 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法
AU2008319987A AU2008319987A1 (en) 2007-10-30 2008-10-28 Utilization of novel compounds with amyloid affinity and method of producing the same
CN2008801234466A CN101909659A (zh) 2007-10-30 2008-10-28 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
US12/740,658 US20100249419A1 (en) 2007-10-30 2008-10-28 Utilization of novel compounds with amyloid affinity and method of producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-282364 2007-10-30
JP2007282364 2007-10-30

Publications (1)

Publication Number Publication Date
WO2009057578A1 true WO2009057578A1 (ja) 2009-05-07

Family

ID=40590969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069504 WO2009057578A1 (ja) 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法

Country Status (9)

Country Link
US (1) US20100249419A1 (ja)
EP (1) EP2216050A4 (ja)
JP (1) JPWO2009057578A1 (ja)
KR (1) KR20100101577A (ja)
CN (1) CN101909659A (ja)
AU (1) AU2008319987A1 (ja)
CA (1) CA2704139A1 (ja)
TW (1) TW200922629A (ja)
WO (1) WO2009057578A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012161116A1 (ja) * 2011-05-20 2012-11-29 日本メジフィジックス株式会社 新規アミロイド親和性化合物
WO2012176587A1 (ja) * 2011-06-24 2012-12-27 日本メジフィジックス株式会社 新規アミロイド親和性化合物
JP5313158B2 (ja) * 2007-10-26 2013-10-09 日本メジフィジックス株式会社 新規アミロイド親和性化合物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
ATE535527T1 (de) * 2006-05-19 2011-12-15 Nihon Mediphysics Co Ltd Verbindung mit affinität zu amyloid
KR20090025282A (ko) * 2006-06-21 2009-03-10 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
JPWO2008056481A1 (ja) * 2006-11-09 2010-02-25 日本メジフィジックス株式会社 放射性画像診断剤
JPWO2008059714A1 (ja) * 2006-11-17 2010-03-04 日本メジフィジックス株式会社 新規アミロイド親和性化合物
TW200823211A (en) * 2006-11-30 2008-06-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
US8343459B2 (en) 2007-02-13 2013-01-01 Nihon Medi-Physics Co., Ltd. Method for production of radiation diagnostic imaging agent
TW200918102A (en) * 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
CA2704172A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
JPWO2009057577A1 (ja) * 2007-10-30 2011-03-10 日本メジフィジックス株式会社 新規アミロイド親和性化合物の使用及び製造方法

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6391391A (ja) * 1986-09-22 1988-04-22 オーソ・フアーマシユーチカル・コーポレーシヨン ２−または３−アリール置換イミダゾ［１，２−ａ］ビリジン
JP2001043978A (ja) * 1999-07-29 2001-02-16 Mitsui Chemicals Inc 有機電界発光素子
WO2001074813A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS
JP2002523383A (ja) 1998-08-20 2002-07-30 リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア βアミロイド斑及び神経原線維変化の標識方法
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
JP2004506723A (ja) 2000-08-24 2004-03-04 ユニバーシティー　オブ　ピッツバーグ アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体
JP2004525192A (ja) * 2001-03-27 2004-08-19 エフ．ホフマン−ラ　ロシュ　アーゲー ｍＧｌｕＲ５アンタゴニストとしてのイミダゾ［１，２−ａ］ピリジン誘導体
JP2005504055A (ja) 2001-08-27 2005-02-10 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用
WO2005016888A1 (ja) 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
JP2005512945A (ja) 2001-04-23 2005-05-12 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア アミロイド斑凝集阻害剤および診断用造影剤
WO2005066177A1 (en) * 2003-12-31 2005-07-21 Schering-Plough Ltd. Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives
JP2005526749A (ja) * 2002-03-06 2005-09-08 ノバルティス アクチエンゲゼルシャフト バイオマーカーとして有用なクマリン
WO2007002540A2 (en) 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
WO2007063946A1 (ja) 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
WO2007135890A1 (ja) * 2006-05-19 2007-11-29 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2008065785A1 (fr) * 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Nouveau composé ayant une affinité pour l'amyloïde

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791117A (en) * 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
US4871745A (en) * 1986-09-22 1989-10-03 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents
US4833149A (en) * 1986-09-22 1989-05-23 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines
JP2001232903A (ja) * 2000-02-23 2001-08-28 Minolta Co Ltd 画像処理装置、画像形成装置、画像処理方法および画像形成方法
US20010051632A1 (en) * 2000-03-31 2001-12-13 Wenying Chai Phenyl-substituted indolizines and tetrahydroindolizines
JP2005193648A (ja) * 2003-12-09 2005-07-21 Canon Inc 印刷制御装置、印刷制御方法およびコンピュータプログラム
JPWO2009057577A1 (ja) * 2007-10-30 2011-03-10 日本メジフィジックス株式会社 新規アミロイド親和性化合物の使用及び製造方法

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6391391A (ja) * 1986-09-22 1988-04-22 オーソ・フアーマシユーチカル・コーポレーシヨン ２−または３−アリール置換イミダゾ［１，２−ａ］ビリジン
JP2002523383A (ja) 1998-08-20 2002-07-30 リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア βアミロイド斑及び神経原線維変化の標識方法
JP2001043978A (ja) * 1999-07-29 2001-02-16 Mitsui Chemicals Inc 有機電界発光素子
WO2001074813A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS
JP2004506723A (ja) 2000-08-24 2004-03-04 ユニバーシティー　オブ　ピッツバーグ アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体
JP2004525192A (ja) * 2001-03-27 2004-08-19 エフ．ホフマン−ラ　ロシュ　アーゲー ｍＧｌｕＲ５アンタゴニストとしてのイミダゾ［１，２−ａ］ピリジン誘導体
JP2005512945A (ja) 2001-04-23 2005-05-12 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア アミロイド斑凝集阻害剤および診断用造影剤
JP2005504055A (ja) 2001-08-27 2005-02-10 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用
JP2005526749A (ja) * 2002-03-06 2005-09-08 ノバルティス アクチエンゲゼルシャフト バイオマーカーとして有用なクマリン
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
WO2005016888A1 (ja) 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
WO2005066177A1 (en) * 2003-12-31 2005-07-21 Schering-Plough Ltd. Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives
WO2007002540A2 (en) 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
WO2007063946A1 (ja) 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
WO2007135890A1 (ja) * 2006-05-19 2007-11-29 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2008065785A1 (fr) * 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Nouveau composé ayant une affinité pour l'amyloïde

Non-Patent Citations (31)

* Cited by examiner, † Cited by third party
Title
BURKE, M.J ET AL., BIOCHEMISTRY, vol. 11, 1972, pages 2435 - 2439
CHRISTOPHER M. CLARK ET AL.: "Imaging Amyloid with I123 IMPY SPECT", ALZHEIMER'S & DEMENTIA: THE JOURNAL OF THE ALZHEIMER'S ASSOCIATION, vol. 2, no. 1, 2006, pages 342
D. M. SKOVRONSKY ET AL., PROC. NAT1. ACAD. SCI., vol. 97, 2000, pages 7609
DOUGLAS D. DISCHINO ET AL., J. NUCL. BED., vol. 24, 1983, pages 1030 - 1038
DOUGLAS D. DISCHINO ET AL., J. NUCL. MED., vol. 24, 1983, pages 1030 - 1038
ERIC D. AGDEPPA ET AL.: "2-Dialkylamino-6-Acyimalononitrile Substituted Naphthalenes (DDNP Analogs): Novel Diagnostic and Therapeutic Tools in Alsheimer's Disease", MOLECULAR IMAGING AND BIOLOGY, vol. 5, 2003, pages 404 - 417
FURUMOTO Y ET AL.: "[11C]BF-227; A New 11C-Labeled 2-Ethenylbenzoxazole Derivative for Amyloid-? Plaques Imaging", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 32, no. L, 2005, pages 759
G. MCKHANN ET AL.: "Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease", NEUROLOGY, vol. 34, 1934, pages 939 - 944
H. F. KUNG ET AL., J. AM. CHEM. SOC., vol. 123, 2001, pages 12740 - 12741
H. F. KUNG ET AL.: "Novel Stilbenes as Probes for amyloid plaques", J. AMERICAN CHEMICAL SOCIETY, vol. 123, 2001, pages 12740 - 12741
HIROYUKI ARAL: "[11C]-BF-227 AND PET to Visualize Amyloid in Alzheimer's Disea.se Patients", ALZHEIMER' S & DEMENTIA: THE JOURNAL OF THE ALZHERMER'S ASSOCIATION, vol. 2, no. 1, 2006, pages 312
J. A. HARDY; G. A. HIGGINS: "Alzheimer's Disease: The Amyloid Cascade Bypothesis", SCIENCE, vol. 256, 1992, pages 184 - 185
KING, L. CARROLL; OSTRUM, G. KENNETH, JOURNAL OF ORGANIC CHEMISTRY, vol. 29, no. 12, 1964, pages 3459 - 3461
MASAHIRO ONO ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 30, 2003, pages 565 - 571
MASAHIRO ONO ET AL.: "HC-labeled .stilbene derivatives as A[3-aggregate-specific PET imaging agents for Alzheimer' sdisease", NUCLEAR MEDICINE AND BIOLOGY, vol. 30, 2003, pages 565 - 571
NAIKI, H. ET AL., LABORATORY INVESTIGATION, vol. 74, 1996, pages 374 - 383
NICOLAAS P. L. G. VERHOEFF ET AL.: "In-Vivo Imaging of Alxheimer Disease ?-Amyloid With [11C] 58-13 PET", AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, vol. 12, 2004, pages 584 - 595
OHHASHI, Y. ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, 2005, pages 32843 - 32848
ORGANIC SYNTHESES , COLL., vol. 79, 2002, pages 59
ORGANIC SYNTHESES, COLL., vol. 74, 1997, pages 248
ORGANIC SYNTHESES, vol. 10, 2004, pages 170
ORGANIC SYNTHESES, vol. 9, 1998, pages 417
See also references of EP2216050A4 *
W. E. KLUNK ET AL.: "Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.", ANN. NEUROL., vol. 55, 2004, pages 306 - 319
WANG, Y. ET AL., J. LABELED COMPOUNDS RADIOPHARMACEUT., vol. 4 4, 2001, pages 239
Z.-P. ZHUANG ET AL.: "Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates", J. MED. CHEM., vol. 44, 2001, pages 1905 - 1914
ZHI -P.ING ZHUANG ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 28, 2001, pages 887 - 894
ZHI-PING ZHUANG ET AL., J. NED. CHEM, vol. 46, 2003, pages 237 - 243
ZHI-PING ZHUANG ET AL.: "1BOX(2-(4 -dim.ethylaminophenyl)-6-iodobensoxazole): a ligind for imaging amyloid plaques in the brain", NUCLEAR MEDICINE AND BÌOLOGY, vol. 28, 2001, pages 887 - 894
ZHI-PING ZHUANG ET AL.: "Structure-Activity Relationship of Imidazo[1,2-a]pyridines as Ligands for Detecting ?-Amyloid Plaques in the Brain", J. MED. CHEM, vol. 46, 2003, pages 237 - 243
ZHUANG, Z.P. ET AL., J. MED. CHEM., vol. 46, 2003, pages 237

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5313158B2 (ja) * 2007-10-26 2013-10-09 日本メジフィジックス株式会社 新規アミロイド親和性化合物
WO2012161116A1 (ja) * 2011-05-20 2012-11-29 日本メジフィジックス株式会社 新規アミロイド親和性化合物
JP5272110B2 (ja) * 2011-05-20 2013-08-28 日本メジフィジックス株式会社 新規アミロイド親和性化合物
US9149546B2 (en) 2011-05-20 2015-10-06 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
WO2012176587A1 (ja) * 2011-06-24 2012-12-27 日本メジフィジックス株式会社 新規アミロイド親和性化合物
JP5167436B2 (ja) * 2011-06-24 2013-03-21 日本メジフィジックス株式会社 新規アミロイド親和性化合物
US9211350B2 (en) 2011-06-24 2015-12-15 Nihon Medi-Physics Co., Ltd. Compound with amyloid affinity

Also Published As

Publication number Publication date
CA2704139A1 (en) 2009-05-07
CN101909659A (zh) 2010-12-08
KR20100101577A (ko) 2010-09-17
EP2216050A4 (en) 2012-11-21
US20100249419A1 (en) 2010-09-30
JPWO2009057578A1 (ja) 2011-03-10
EP2216050A1 (en) 2010-08-11
TW200922629A (en) 2009-06-01
AU2008319987A1 (en) 2009-05-07

Similar Documents

Publication Publication Date Title
WO2009057578A1 (ja) 新規アミロイド親和性化合物の使用及び製造方法
WO2009054497A1 (ja) 新規アミロイド親和性化合物
WO2009054496A1 (ja) 新規アミロイド親和性化合物
WO2007009637A3 (de) Deren verwendung als kontrastmittel zur anwendung in der nmr-, rontgen- und radiodiagnostik sowie in der radiotheraphie
IL209650A0 (en) Novel compound having affinity for amyloid
WO2008044243A3 (en) Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
EP2289564A3 (en) Derivatives of aniline as precursors for F18-labeling
WO2009019005A8 (en) Tricyclic bridged cyclopentanedione derivatives as herbicides
EP2098522A4 (en) NEW CONNECTION WITH AFFINITY TO AMYLOID
WO2009019575A3 (en) Underlayer coating composition based on a crosslinkable polymer
WO2010120942A3 (en) Histone modification patterns for clinical diagnosis and prognosis of cancer
WO2009057576A1 (ja) 新規アミロイド親和性化合物の使用及び製造方法
IL194889A0 (en) Compound having affinity to amyloid
WO2007016029A3 (en) Diazepinoquinolines, synthesis thereof, and intermediates thereto
WO2007056175A3 (en) 41-methoxy isotope labeled rapamycin 42-ester
WO2008090757A1 (ja) スクアリリウム化合物、スクアリリウム化合物含有組成物、光学フィルター及びディスプレイ用前面フィルター
MX2009003617A (es) Derivados de silicio para obtencion de imagenes por tomografia de emision de positrones (pet).
WO2009057577A1 (ja) 新規アミロイド親和性化合物の使用及び製造方法
WO2009057575A1 (ja) 新規アミロイド親和性化合物の使用及び製造方法
MXPA05005256A (es) Nuevos compuestos de pirrolidina y tiazolidina, un proceso para su preparacion y composiciones farmaceuticas que los contienen.
CR11084A (es) Compuesto biciclico y uso farmaceutico del mismo
WO2009072649A1 (ja) ４－アリールフェニル誘導体
WO2006094198A8 (en) Surfaces coated with target-induced fluorescent compounds for detection of target elements
TW200616982A (en) Trimeric, macrocyclically substituted aminoisophthalic acid-halo-benzene derivatives
EP1719529A4 (en) CONTRASTING FOR THROMBUS EDUCATION

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880123446.6

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08843543

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009539060

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2704139

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 12740658

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 20107011451

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2008843543

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008319987

Country of ref document: AU

Date of ref document: 20081028

Kind code of ref document: A