WO2009057576A1 - 新規アミロイド親和性化合物の使用及び製造方法 - Google Patents
新規アミロイド親和性化合物の使用及び製造方法 Download PDFInfo
- Publication number
- WO2009057576A1 WO2009057576A1 PCT/JP2008/069502 JP2008069502W WO2009057576A1 WO 2009057576 A1 WO2009057576 A1 WO 2009057576A1 JP 2008069502 W JP2008069502 W JP 2008069502W WO 2009057576 A1 WO2009057576 A1 WO 2009057576A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amyloid
- affinity
- carbon
- production
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008801234061A CN101909657A (zh) | 2007-10-30 | 2008-10-28 | 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法 |
US12/740,627 US20100267952A1 (en) | 2007-10-30 | 2008-10-28 | Use of novel compound having affinity for amyloid, and process for production of the same |
JP2009539058A JPWO2009057576A1 (ja) | 2007-10-30 | 2008-10-28 | 新規アミロイド親和性化合物の使用及び製造方法 |
AU2008319985A AU2008319985A1 (en) | 2007-10-30 | 2008-10-28 | Use of novel compound having affinity for amyloid, and process for production of the same |
EP08843899A EP2218463A1 (en) | 2007-10-30 | 2008-10-28 | Use of novel compound having affinity for amyloid, and process for production of the same |
CA2704172A CA2704172A1 (en) | 2007-10-30 | 2008-10-28 | Use of novel compound having affinity for amyloid, and process for production of the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007282362 | 2007-10-30 | ||
JP2007-282362 | 2007-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009057576A1 true WO2009057576A1 (ja) | 2009-05-07 |
Family
ID=40590967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/069502 WO2009057576A1 (ja) | 2007-10-30 | 2008-10-28 | 新規アミロイド親和性化合物の使用及び製造方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20100267952A1 (ja) |
EP (1) | EP2218463A1 (ja) |
JP (1) | JPWO2009057576A1 (ja) |
KR (1) | KR20100089858A (ja) |
CN (1) | CN101909657A (ja) |
AU (1) | AU2008319985A1 (ja) |
CA (1) | CA2704172A1 (ja) |
TW (1) | TW200920408A (ja) |
WO (1) | WO2009057576A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012161116A1 (ja) * | 2011-05-20 | 2012-11-29 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物 |
JP5313158B2 (ja) * | 2007-10-26 | 2013-10-09 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物 |
US9211350B2 (en) | 2011-06-24 | 2015-12-15 | Nihon Medi-Physics Co., Ltd. | Compound with amyloid affinity |
JP2016533334A (ja) * | 2013-09-26 | 2016-10-27 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 画像化ツールとしてのイミダゾ[1,2−a]ピリジン−7−アミン |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100091965A (ko) * | 2007-10-24 | 2010-08-19 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6391391A (ja) * | 1986-09-22 | 1988-04-22 | オーソ・フアーマシユーチカル・コーポレーシヨン | 2−または3−アリール置換イミダゾ[1,2−a]ビリジン |
JP2001043978A (ja) * | 1999-07-29 | 2001-02-16 | Mitsui Chemicals Inc | 有機電界発光素子 |
WO2001074813A2 (en) * | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS |
JP2004525192A (ja) * | 2001-03-27 | 2004-08-19 | エフ.ホフマン−ラ ロシュ アーゲー | mGluR5アンタゴニストとしてのイミダゾ[1,2−a]ピリジン誘導体 |
JP2005512945A (ja) * | 2001-04-23 | 2005-05-12 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | アミロイド斑凝集阻害剤および診断用造影剤 |
WO2005066177A1 (en) * | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives |
JP2005526749A (ja) * | 2002-03-06 | 2005-09-08 | ノバルティス アクチエンゲゼルシャフト | バイオマーカーとして有用なクマリン |
WO2007135890A1 (ja) * | 2006-05-19 | 2007-11-29 | Nihon Medi-Physics Co., Ltd. | 新規アミロイド親和性化合物 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US4833149A (en) * | 1986-09-22 | 1989-05-23 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines |
US4871745A (en) * | 1986-09-22 | 1989-10-03 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents |
US4791117A (en) * | 1986-09-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers |
EP0859642A2 (en) * | 1995-10-17 | 1998-08-26 | G.D. Searle & Co. | Method of detecting cyclooxygenase-2 |
US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
US20010051632A1 (en) * | 2000-03-31 | 2001-12-13 | Wenying Chai | Phenyl-substituted indolizines and tetrahydroindolizines |
US6514969B2 (en) * | 2000-08-16 | 2003-02-04 | Boehringer Ingelheim Pharma Kg | β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions |
AU2002253999A1 (en) * | 2001-02-26 | 2002-09-12 | Bristol-Myers Squibb Pharma Company | Ascorbic acid analogs for metalloradiopharmaceuticals |
EP1356827A1 (en) * | 2002-04-24 | 2003-10-29 | Mallinckrodt Inc. | Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution |
GB0229695D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase preparation of 18F-labelled amino acids |
JP4738419B2 (ja) * | 2005-11-30 | 2011-08-03 | 富士フイルムRiファーマ株式会社 | アミロイドの凝集及び/又は沈着に起因する疾患の診断薬及び治療薬 |
US8207189B2 (en) * | 2006-11-30 | 2012-06-26 | Nihon Medi-Physics Co., Ltd. | Compound having affinity for amyloid |
KR20100091965A (ko) * | 2007-10-24 | 2010-08-19 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물 |
US8399672B2 (en) * | 2007-10-26 | 2013-03-19 | Nihon Medi-Physics Co., Ltd. | Compound having affinity for amyloid |
EP2216050A4 (en) * | 2007-10-30 | 2012-11-21 | Nihon Mediphysics Co Ltd | USE OF NEW COMPOUNDS WITH AMYLOID AFFINITY AND METHOD OF MANUFACTURING THEREOF |
-
2008
- 2008-10-28 EP EP08843899A patent/EP2218463A1/en not_active Withdrawn
- 2008-10-28 TW TW097141472A patent/TW200920408A/zh unknown
- 2008-10-28 CA CA2704172A patent/CA2704172A1/en not_active Abandoned
- 2008-10-28 KR KR1020107011449A patent/KR20100089858A/ko not_active Application Discontinuation
- 2008-10-28 CN CN2008801234061A patent/CN101909657A/zh active Pending
- 2008-10-28 AU AU2008319985A patent/AU2008319985A1/en not_active Abandoned
- 2008-10-28 JP JP2009539058A patent/JPWO2009057576A1/ja not_active Ceased
- 2008-10-28 WO PCT/JP2008/069502 patent/WO2009057576A1/ja active Application Filing
- 2008-10-28 US US12/740,627 patent/US20100267952A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6391391A (ja) * | 1986-09-22 | 1988-04-22 | オーソ・フアーマシユーチカル・コーポレーシヨン | 2−または3−アリール置換イミダゾ[1,2−a]ビリジン |
JP2001043978A (ja) * | 1999-07-29 | 2001-02-16 | Mitsui Chemicals Inc | 有機電界発光素子 |
WO2001074813A2 (en) * | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS |
JP2004525192A (ja) * | 2001-03-27 | 2004-08-19 | エフ.ホフマン−ラ ロシュ アーゲー | mGluR5アンタゴニストとしてのイミダゾ[1,2−a]ピリジン誘導体 |
JP2005512945A (ja) * | 2001-04-23 | 2005-05-12 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | アミロイド斑凝集阻害剤および診断用造影剤 |
JP2005526749A (ja) * | 2002-03-06 | 2005-09-08 | ノバルティス アクチエンゲゼルシャフト | バイオマーカーとして有用なクマリン |
WO2005066177A1 (en) * | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives |
WO2007135890A1 (ja) * | 2006-05-19 | 2007-11-29 | Nihon Medi-Physics Co., Ltd. | 新規アミロイド親和性化合物 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5313158B2 (ja) * | 2007-10-26 | 2013-10-09 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物 |
WO2012161116A1 (ja) * | 2011-05-20 | 2012-11-29 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物 |
JP5272110B2 (ja) * | 2011-05-20 | 2013-08-28 | 日本メジフィジックス株式会社 | 新規アミロイド親和性化合物 |
US9149546B2 (en) | 2011-05-20 | 2015-10-06 | Nihon Medi-Physics Co., Ltd. | Compound having affinity for amyloid |
US9211350B2 (en) | 2011-06-24 | 2015-12-15 | Nihon Medi-Physics Co., Ltd. | Compound with amyloid affinity |
JP2016533334A (ja) * | 2013-09-26 | 2016-10-27 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 画像化ツールとしてのイミダゾ[1,2−a]ピリジン−7−アミン |
US9957266B2 (en) | 2013-09-26 | 2018-05-01 | Hoffmann-La Roche Inc. | Imidazo[1,2-a]pyridin-7-amine |
Also Published As
Publication number | Publication date |
---|---|
CA2704172A1 (en) | 2009-05-07 |
EP2218463A1 (en) | 2010-08-18 |
CN101909657A (zh) | 2010-12-08 |
TW200920408A (en) | 2009-05-16 |
JPWO2009057576A1 (ja) | 2011-03-10 |
AU2008319985A1 (en) | 2009-05-07 |
KR20100089858A (ko) | 2010-08-12 |
US20100267952A1 (en) | 2010-10-21 |
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