WO2009057576A1 - 新規アミロイド親和性化合物の使用及び製造方法 - Google Patents

新規アミロイド親和性化合物の使用及び製造方法 Download PDF

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Publication number
WO2009057576A1
WO2009057576A1 PCT/JP2008/069502 JP2008069502W WO2009057576A1 WO 2009057576 A1 WO2009057576 A1 WO 2009057576A1 JP 2008069502 W JP2008069502 W JP 2008069502W WO 2009057576 A1 WO2009057576 A1 WO 2009057576A1
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Prior art keywords
amyloid
affinity
carbon
production
same
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PCT/JP2008/069502
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English (en)
French (fr)
Inventor
Shigeyuki Tanifuji
Daisaku Nakamura
Shinya Takasaki
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Nihon Medi-Physics Co., Ltd.
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Application filed by Nihon Medi-Physics Co., Ltd. filed Critical Nihon Medi-Physics Co., Ltd.
Priority to CN2008801234061A priority Critical patent/CN101909657A/zh
Priority to US12/740,627 priority patent/US20100267952A1/en
Priority to JP2009539058A priority patent/JPWO2009057576A1/ja
Priority to AU2008319985A priority patent/AU2008319985A1/en
Priority to EP08843899A priority patent/EP2218463A1/en
Priority to CA2704172A priority patent/CA2704172A1/en
Publication of WO2009057576A1 publication Critical patent/WO2009057576A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

アミロイドへの親和性を有し、かつ、変異原性等の毒性がおさえられた化合物を用いて、インビトロ（ｉｎ ｖｉｔｒｏ）及びインビボ（ｉｎ ｖｉｖｏ）でアミロイドを高感度に検出し得る、生体組織中のアミロイドの検出試薬を提供する。 下記式（１）で表される化合物またはその塩を含有してなる、生体組織に沈着したアミロイドの検出試薬。　　（式中、Ａ１、Ａ２、Ａ３及びＡ４はそれぞれ独立に炭素又は窒素、Ｒ１はハロゲン置換基、Ｒ２はハロゲン置換基、ｍは０～２の整数である。ただし、Ｒ１及びＲ２の少なくともいずれか一方は放射性ハロゲン置換基であり、かつ、Ａ１、Ａ２、Ａ３及びＡ４のうちの少なくとも一つは炭素であって、Ｒ１は、炭素であるＡ１、Ａ２、Ａ３及びＡ４に結合する。）
PCT/JP2008/069502 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法 WO2009057576A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN2008801234061A CN101909657A (zh) 2007-10-30 2008-10-28 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
US12/740,627 US20100267952A1 (en) 2007-10-30 2008-10-28 Use of novel compound having affinity for amyloid, and process for production of the same
JP2009539058A JPWO2009057576A1 (ja) 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法
AU2008319985A AU2008319985A1 (en) 2007-10-30 2008-10-28 Use of novel compound having affinity for amyloid, and process for production of the same
EP08843899A EP2218463A1 (en) 2007-10-30 2008-10-28 Use of novel compound having affinity for amyloid, and process for production of the same
CA2704172A CA2704172A1 (en) 2007-10-30 2008-10-28 Use of novel compound having affinity for amyloid, and process for production of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007282362 2007-10-30
JP2007-282362 2007-10-30

Publications (1)

Publication Number Publication Date
WO2009057576A1 true WO2009057576A1 (ja) 2009-05-07

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PCT/JP2008/069502 WO2009057576A1 (ja) 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法

Country Status (9)

Country Link
US (1) US20100267952A1 (ja)
EP (1) EP2218463A1 (ja)
JP (1) JPWO2009057576A1 (ja)
KR (1) KR20100089858A (ja)
CN (1) CN101909657A (ja)
AU (1) AU2008319985A1 (ja)
CA (1) CA2704172A1 (ja)
TW (1) TW200920408A (ja)
WO (1) WO2009057576A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012161116A1 (ja) * 2011-05-20 2012-11-29 日本メジフィジックス株式会社 新規アミロイド親和性化合物
JP5313158B2 (ja) * 2007-10-26 2013-10-09 日本メジフィジックス株式会社 新規アミロイド親和性化合物
US9211350B2 (en) 2011-06-24 2015-12-15 Nihon Medi-Physics Co., Ltd. Compound with amyloid affinity
JP2016533334A (ja) * 2013-09-26 2016-10-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン

Families Citing this family (1)

* Cited by examiner, † Cited by third party
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KR20100091965A (ko) * 2007-10-24 2010-08-19 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물

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JPS6391391A (ja) * 1986-09-22 1988-04-22 オーソ・フアーマシユーチカル・コーポレーシヨン ２−または３−アリール置換イミダゾ［１，２−ａ］ビリジン
JP2001043978A (ja) * 1999-07-29 2001-02-16 Mitsui Chemicals Inc 有機電界発光素子
WO2001074813A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS
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KR20100091965A (ko) * 2007-10-24 2010-08-19 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
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WO2007135890A1 (ja) * 2006-05-19 2007-11-29 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5313158B2 (ja) * 2007-10-26 2013-10-09 日本メジフィジックス株式会社 新規アミロイド親和性化合物
WO2012161116A1 (ja) * 2011-05-20 2012-11-29 日本メジフィジックス株式会社 新規アミロイド親和性化合物
JP5272110B2 (ja) * 2011-05-20 2013-08-28 日本メジフィジックス株式会社 新規アミロイド親和性化合物
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JP2016533334A (ja) * 2013-09-26 2016-10-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン
US9957266B2 (en) 2013-09-26 2018-05-01 Hoffmann-La Roche Inc. Imidazo[1,2-a]pyridin-7-amine

Also Published As

Publication number Publication date
CA2704172A1 (en) 2009-05-07
EP2218463A1 (en) 2010-08-18
CN101909657A (zh) 2010-12-08
TW200920408A (en) 2009-05-16
JPWO2009057576A1 (ja) 2011-03-10
AU2008319985A1 (en) 2009-05-07
KR20100089858A (ko) 2010-08-12
US20100267952A1 (en) 2010-10-21

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