WO2009057577A1 - 新規アミロイド親和性化合物の使用及び製造方法 - Google Patents

新規アミロイド親和性化合物の使用及び製造方法 Download PDF

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Publication number
WO2009057577A1
WO2009057577A1 PCT/JP2008/069503 JP2008069503W WO2009057577A1 WO 2009057577 A1 WO2009057577 A1 WO 2009057577A1 JP 2008069503 W JP2008069503 W JP 2008069503W WO 2009057577 A1 WO2009057577 A1 WO 2009057577A1
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WO
WIPO (PCT)
Prior art keywords
group
amyloid
carbon
affinity
substituent
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Application number
PCT/JP2008/069503
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English (en)
French (fr)
Inventor
Shigeyuki Tanifuji
Daisaku Nakamura
Shinya Takasaki
Yuki Okumura
Original Assignee
Nihon Medi-Physics Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi-Physics Co., Ltd. filed Critical Nihon Medi-Physics Co., Ltd.
Priority to CA2704137A priority Critical patent/CA2704137A1/en
Priority to EP08845375A priority patent/EP2216052A4/en
Priority to CN2008801234076A priority patent/CN101909658A/zh
Priority to JP2009539059A priority patent/JPWO2009057577A1/ja
Priority to AU2008319986A priority patent/AU2008319986A1/en
Priority to US12/740,646 priority patent/US20100216994A1/en
Publication of WO2009057577A1 publication Critical patent/WO2009057577A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Abstract

アミロイドへの親和性を有する化合物を用いて、インビトロ（ｉｎ ｖｉｔｒｏ）及びインビボ（ｉｎ ｖｉｖｏ）でアミロイドを高感度に検出し得る試薬を提供する。 下記式（１）で表される化合物またはその塩を含有してなる、生体組織に沈着したアミロイドの検出試薬。　　（式中、Ａ１、Ａ２、Ａ３及びＡ４はそれぞれ独立に炭素又は窒素、 Ｒ１は水素、水酸基、カルボキシル基、硫酸基、アミノ基、ニトロ基、シアノ基、非放射性ハロゲン置換基、炭素数１～４のアルキル置換基及び炭素数１～４のアルコキシ置換基からなる群より選ばれる基、Ｒ２は放射性ハロゲン置換基である。 ただし、Ａ１、Ａ２、Ａ３及びＡ４のうちの少なくとも一つは炭素であって、Ｒ１は、炭素であるＡ１、Ａ２、Ａ３及びＡ４に結合する。）
PCT/JP2008/069503 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法 WO2009057577A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2704137A CA2704137A1 (en) 2007-10-30 2008-10-28 Use of novel compound having affinity for amyloid, and process for production of the same
EP08845375A EP2216052A4 (en) 2007-10-30 2008-10-28 USE OF A NEW COMPOUND WITH AFFINITY FOR AMYLOID AND METHOD FOR THE PRODUCTION THEREOF
CN2008801234076A CN101909658A (zh) 2007-10-30 2008-10-28 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
JP2009539059A JPWO2009057577A1 (ja) 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法
AU2008319986A AU2008319986A1 (en) 2007-10-30 2008-10-28 Use of novel compound having affinity for amyloid, and process for production of the same
US12/740,646 US20100216994A1 (en) 2007-10-30 2008-10-28 Use of novel compound having affinity for amyloid, and process for production of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-282363 2007-10-30
JP2007282363 2007-10-30

Publications (1)

Publication Number Publication Date
WO2009057577A1 true WO2009057577A1 (ja) 2009-05-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069503 WO2009057577A1 (ja) 2007-10-30 2008-10-28 新規アミロイド親和性化合物の使用及び製造方法

Country Status (9)

Country Link
US (1) US20100216994A1 (ja)
EP (1) EP2216052A4 (ja)
JP (1) JPWO2009057577A1 (ja)
KR (1) KR20100101576A (ja)
CN (2) CN101909658A (ja)
AU (1) AU2008319986A1 (ja)
CA (1) CA2704137A1 (ja)
TW (1) TW200922628A (ja)
WO (1) WO2009057577A1 (ja)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
WO2012017739A1 (ja) * 2010-07-31 2012-02-09 エレコン科学株式会社 アミロイドアッセイ装置およびアミロイドアッセイ方法
JP2016520046A (ja) * 2013-04-29 2016-07-11 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ２−フェニル又は２−ヘタリールイミダゾール［１，２−ａ］ピリジン誘導体
JP2017529340A (ja) * 2014-08-29 2017-10-05 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ

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JPWO2009057578A1 (ja) * 2007-10-30 2011-03-10 日本メジフィジックス株式会社 新規アミロイド親和性化合物の使用及び製造方法

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012017739A1 (ja) * 2010-07-31 2012-02-09 エレコン科学株式会社 アミロイドアッセイ装置およびアミロイドアッセイ方法
JP5841945B2 (ja) * 2010-07-31 2016-01-13 祐児 後藤 アミロイドアッセイ装置およびアミロイドアッセイ方法
JP2016520046A (ja) * 2013-04-29 2016-07-11 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ２−フェニル又は２−ヘタリールイミダゾール［１，２−ａ］ピリジン誘導体
US10975073B2 (en) 2013-04-29 2021-04-13 Hoffmann-La Roche Inc. Imaging methods using 2-hetaryl imidazol[1,2-a]pyridine derivatives
US11358962B2 (en) 2013-04-29 2022-06-14 Hoffmann-La Roche Inc. 2-hetaryl imidazol[1,2-a]pyridine derivatives
JP2017529340A (ja) * 2014-08-29 2017-10-05 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチントンタンパク質のイメージング用プローブ

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CN102702195A (zh) 2012-10-03
CA2704137A1 (en) 2009-05-07
TW200922628A (en) 2009-06-01
AU2008319986A1 (en) 2009-05-07
JPWO2009057577A1 (ja) 2011-03-10
EP2216052A1 (en) 2010-08-11
US20100216994A1 (en) 2010-08-26
CN101909658A (zh) 2010-12-08
KR20100101576A (ko) 2010-09-17
EP2216052A4 (en) 2012-11-21

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