WO2009054458A1 - 血中の糖、マロンジアルデヒド修飾ldl、ホモシステイン及び/又はc反応性タンパク質を低減するための組成物 - Google Patents
血中の糖、マロンジアルデヒド修飾ldl、ホモシステイン及び/又はc反応性タンパク質を低減するための組成物 Download PDFInfo
- Publication number
- WO2009054458A1 WO2009054458A1 PCT/JP2008/069244 JP2008069244W WO2009054458A1 WO 2009054458 A1 WO2009054458 A1 WO 2009054458A1 JP 2008069244 W JP2008069244 W JP 2008069244W WO 2009054458 A1 WO2009054458 A1 WO 2009054458A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- malondialdehyde
- homocysteine
- glucose
- blood
- reducing
- Prior art date
Links
- 108010074051 C-Reactive Protein Proteins 0.000 title abstract 3
- 102100032752 C-reactive protein Human genes 0.000 title abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 3
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 title abstract 3
- 239000008280 blood Substances 0.000 title abstract 3
- 210000004369 blood Anatomy 0.000 title abstract 3
- 239000008103 glucose Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 1
- 229930003779 Vitamin B12 Natural products 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- 229960000304 folic acid Drugs 0.000 abstract 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract 1
- 239000011669 selenium Substances 0.000 abstract 1
- 229910052711 selenium Inorganic materials 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 235000019163 vitamin B12 Nutrition 0.000 abstract 1
- 239000011715 vitamin B12 Substances 0.000 abstract 1
- 235000019158 vitamin B6 Nutrition 0.000 abstract 1
- 239000011726 vitamin B6 Substances 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- Inorganic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES08841027.9T ES2664826T3 (es) | 2007-10-25 | 2008-10-23 | Composición para reducir el nivel glucosa, LDL modificada con malondialdehído, homocisteína y/o proteína c-reactiva en sangre |
CA2703645A CA2703645C (en) | 2007-10-25 | 2008-10-23 | Composition for reducing the level of glucose, malondialdehyde-modified ldl, homocysteine and/or c-reactive protein in blood |
US12/739,701 US10383893B2 (en) | 2007-10-25 | 2008-10-23 | Composition for reducing the level of glucose, malondialdehyde-modified LDL, homocysteine and/or C-reactive protein in blood |
CN200880112375A CN101835477A (zh) | 2007-10-25 | 2008-10-23 | 用于降低血中的糖、丙二醛修饰ldl、同型半胱氨酸和/或c反应蛋白的组合物 |
DK08841027.9T DK2221059T3 (en) | 2007-10-25 | 2008-10-23 | Composition for reducing the level of glucose, malondialdehyde-modified LDL, homocysteine and / or c-reactive protein in blood |
KR1020107011255A KR101290514B1 (ko) | 2007-10-25 | 2008-10-23 | 혈중의 당, 말론디알데히드 수식 ldl, 호모시스테인 및/또는 c 반응성 단백질을 저감시키기 위한 조성물 |
JP2009538253A JP5798717B2 (ja) | 2007-10-25 | 2008-10-23 | 血中の糖、マロンジアルデヒド修飾ldl、ホモシステイン及び/又はc反応性タンパク質を低減するための組成物 |
EP08841027.9A EP2221059B1 (en) | 2007-10-25 | 2008-10-23 | Composition for reducing the level of glucose, malondialdehyde-modified ldl, homocysteine and/or c-reactive protein in blood |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-277140 | 2007-10-25 | ||
JP2007277140 | 2007-10-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009054458A1 true WO2009054458A1 (ja) | 2009-04-30 |
Family
ID=40579560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/069244 WO2009054458A1 (ja) | 2007-10-25 | 2008-10-23 | 血中の糖、マロンジアルデヒド修飾ldl、ホモシステイン及び/又はc反応性タンパク質を低減するための組成物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US10383893B2 (ja) |
EP (1) | EP2221059B1 (ja) |
JP (1) | JP5798717B2 (ja) |
KR (1) | KR101290514B1 (ja) |
CN (2) | CN101835477A (ja) |
CA (1) | CA2703645C (ja) |
DK (1) | DK2221059T3 (ja) |
ES (1) | ES2664826T3 (ja) |
WO (1) | WO2009054458A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011236191A (ja) * | 2010-05-11 | 2011-11-24 | Shunzo Kobayashi | 動脈硬化改善剤 |
WO2012141018A1 (ja) * | 2011-04-15 | 2012-10-18 | ライオン株式会社 | 組成物、及び糖代謝改善剤、並びに糖代謝改善方法 |
JP2014501759A (ja) * | 2010-12-21 | 2014-01-23 | ネステク ソシエテ アノニム | 動物の血糖管理に適した方法及び組成物 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018220224A1 (en) | 2017-06-02 | 2018-12-06 | Medirista Biotechnologies Ab | Lipid-related antigens and antibodies directed against them |
CN111239292B (zh) * | 2019-10-24 | 2022-11-25 | 丁芬 | 同时检测多种脂溶性维生素和同型半胱氨酸的方法 |
CN115702906A (zh) * | 2021-08-09 | 2023-02-17 | 深圳奥萨制药有限公司 | 一种预防改善心血管疾病的组合物 |
Citations (10)
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JPH06192105A (ja) * | 1992-09-14 | 1994-07-12 | Vesta Medicines Pty Ltd | ホモシステインのレベルを下げるための医薬製剤 |
JP2002504928A (ja) * | 1997-06-19 | 2002-02-12 | ライコード・ナチユラル・プロダクツ・インダストリーズ・リミテツド | Ldlの酸化を防止するための天然組成物 |
JP2002348244A (ja) * | 2001-05-23 | 2002-12-04 | Fancl Corp | 抗糖尿病組成物 |
JP2003504333A (ja) * | 1999-07-14 | 2003-02-04 | ラクスディル リミテッド | 必須脂肪酸およびホモシステイン低下剤を含有する製剤および栄養組成物 |
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CA2703645A1 (en) | 2009-04-30 |
CN104224835A (zh) | 2014-12-24 |
JP5798717B2 (ja) | 2015-10-21 |
US20100247505A1 (en) | 2010-09-30 |
EP2221059A4 (en) | 2010-12-15 |
KR101290514B1 (ko) | 2013-07-26 |
EP2221059A1 (en) | 2010-08-25 |
US10383893B2 (en) | 2019-08-20 |
CA2703645C (en) | 2015-01-27 |
DK2221059T3 (en) | 2018-03-12 |
CN101835477A (zh) | 2010-09-15 |
EP2221059B1 (en) | 2018-01-17 |
ES2664826T3 (es) | 2018-04-23 |
KR20100080560A (ko) | 2010-07-08 |
JPWO2009054458A1 (ja) | 2011-03-10 |
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