WO2009051244A1 - 複素環化合物 - Google Patents

複素環化合物 Download PDF

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Publication number
WO2009051244A1
WO2009051244A1 PCT/JP2008/068901 JP2008068901W WO2009051244A1 WO 2009051244 A1 WO2009051244 A1 WO 2009051244A1 JP 2008068901 W JP2008068901 W JP 2008068901W WO 2009051244 A1 WO2009051244 A1 WO 2009051244A1
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WIPO (PCT)
Prior art keywords
heterocyclic compound
rbp4
compound
formula
diseases
Prior art date
Application number
PCT/JP2008/068901
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English (en)
French (fr)
Inventor
Shizuo Kasai
Tomohiro Kaku
Masahiro Kamaura
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Takeda Pharmaceutical Company Limited
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Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Priority to US12/738,486 priority Critical patent/US8586571B2/en
Priority to EP08838911.9A priority patent/EP2202223B1/en
Priority to JP2009538178A priority patent/JP5374377B2/ja
Publication of WO2009051244A1 publication Critical patent/WO2009051244A1/ja
Priority to US14/055,585 priority patent/US9487509B2/en

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

　本発明は、 （式中、各記号は、明細書中で定義されるとおりである） に関する。本化合物は、優れたRBP4低下作用を有し、RBP4の上昇によって媒介される疾患又は症状の予防又は治療用薬剤として有用である。
PCT/JP2008/068901 2007-10-18 2008-10-17 複素環化合物 WO2009051244A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/738,486 US8586571B2 (en) 2007-10-18 2008-10-17 Heterocyclic compound
EP08838911.9A EP2202223B1 (en) 2007-10-18 2008-10-17 Heterocyclic compound as blood rbp4 lowering agent
JP2009538178A JP5374377B2 (ja) 2007-10-18 2008-10-17 複素環化合物
US14/055,585 US9487509B2 (en) 2007-10-18 2013-10-16 Heterocyclic compound

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US96089707P 2007-10-18 2007-10-18
US60/960,897 2007-10-18

Related Child Applications (2)

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US12/738,486 A-371-Of-International US8586571B2 (en) 2007-10-18 2008-10-17 Heterocyclic compound
US14/055,585 Division US9487509B2 (en) 2007-10-18 2013-10-16 Heterocyclic compound

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WO2009051244A1 true WO2009051244A1 (ja) 2009-04-23

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EP (1) EP2202223B1 (ja)
JP (1) JP5374377B2 (ja)
WO (1) WO2009051244A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
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WO2010119992A1 (en) 2009-04-16 2010-10-21 Takeda Pharmaceutical Company Limited Derivatives of n-acyl-n'-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
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US20140066420A1 (en) 2014-03-06
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US8586571B2 (en) 2013-11-19
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US9487509B2 (en) 2016-11-08
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