WO2009051210A1 - ピラゾール縮合環誘導体の製造方法 - Google Patents

ピラゾール縮合環誘導体の製造方法 Download PDF

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Publication number
WO2009051210A1
WO2009051210A1 PCT/JP2008/068822 JP2008068822W WO2009051210A1 WO 2009051210 A1 WO2009051210 A1 WO 2009051210A1 JP 2008068822 W JP2008068822 W JP 2008068822W WO 2009051210 A1 WO2009051210 A1 WO 2009051210A1
Authority
WO
WIPO (PCT)
Prior art keywords
fused ring
ring derivative
producing
compound
pyrazole fused
Prior art date
Application number
PCT/JP2008/068822
Other languages
English (en)
French (fr)
Inventor
Keizo Sato
Kazumasa Nara
Naoyuki Shimomura
Original Assignee
Eisai R & D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R & D Management Co., Ltd. filed Critical Eisai R & D Management Co., Ltd.
Priority to CA2702958A priority Critical patent/CA2702958A1/en
Priority to MX2010004135A priority patent/MX2010004135A/es
Priority to JP2009538156A priority patent/JPWO2009051210A1/ja
Priority to US12/738,514 priority patent/US20100217001A1/en
Priority to CN200880111926A priority patent/CN101827843A/zh
Priority to BRPI0817839-9A priority patent/BRPI0817839A2/pt
Priority to EP08840583A priority patent/EP2202233A4/en
Publication of WO2009051210A1 publication Critical patent/WO2009051210A1/ja
Priority to IL204822A priority patent/IL204822A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Abstract

本発明は、ピラゾール縮合環誘導体（７－フェニルピラゾロ［１，５－ａ］ピリジン誘導体）の工業的に有用な製造方法を提供する。本発明は、下式で表される化合物（Ｉ）またはその塩の製造方法であって、下式で表される化合物（ＩＶ）における水酸基をメトキシ基に変換し、化合物（Ｉ）またはその塩を得る工程Ａを含む方法により、上記課題を解決する。
PCT/JP2008/068822 2007-10-18 2008-10-17 ピラゾール縮合環誘導体の製造方法 WO2009051210A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2702958A CA2702958A1 (en) 2007-10-18 2008-10-17 Method for producing pyrazole fused ring derivative
MX2010004135A MX2010004135A (es) 2007-10-18 2008-10-17 Metodo para producir un derivado en anillo fusionado a pirazol.
JP2009538156A JPWO2009051210A1 (ja) 2007-10-18 2008-10-17 ピラゾール縮合環誘導体の製造方法
US12/738,514 US20100217001A1 (en) 2007-10-18 2008-10-17 Method for producing pyrazole fused ring derivative
CN200880111926A CN101827843A (zh) 2007-10-18 2008-10-17 吡唑稠环衍生物的制备方法
BRPI0817839-9A BRPI0817839A2 (pt) 2007-10-18 2008-10-17 Método para produzir derivado de anel fundido de pirazol
EP08840583A EP2202233A4 (en) 2007-10-18 2008-10-17 METHOD FOR PRODUCING PYRAZOLE DERIVATIVE WITH FUSED CYCLES
IL204822A IL204822A0 (en) 2007-10-18 2010-03-28 Method for producing pyrazole fused ring derivative

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007271068 2007-10-18
JP2007-271068 2007-10-18
JP2008-107868 2008-04-17
JP2008107868 2008-04-17

Publications (1)

Publication Number Publication Date
WO2009051210A1 true WO2009051210A1 (ja) 2009-04-23

Family

ID=40567471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068822 WO2009051210A1 (ja) 2007-10-18 2008-10-17 ピラゾール縮合環誘導体の製造方法

Country Status (10)

Country Link
US (1) US20100217001A1 (ja)
EP (1) EP2202233A4 (ja)
JP (1) JPWO2009051210A1 (ja)
CN (1) CN101827843A (ja)
BR (1) BRPI0817839A2 (ja)
CA (1) CA2702958A1 (ja)
IL (1) IL204822A0 (ja)
MX (1) MX2010004135A (ja)
RU (1) RU2010119706A (ja)
WO (1) WO2009051210A1 (ja)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037822A1 (ja) 2002-10-22 2004-05-06 Eisai Co., Ltd. ７−フェニルピラゾロピリジン化合物
WO2005100354A1 (ja) 2004-04-12 2005-10-27 Eisai R & D Management Co., Ltd. ピラゾール縮合環誘導体の製造方法
JP2005314355A (ja) * 2004-03-29 2005-11-10 Cambridge Univ Technical Services Ltd 化合物の合成方法および合成反応触媒

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7411082B2 (en) * 2004-03-29 2008-08-12 Cambridge University Technical Services Ltd. Synthesizing method for compound, and catalyst for synthesis reaction

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037822A1 (ja) 2002-10-22 2004-05-06 Eisai Co., Ltd. ７−フェニルピラゾロピリジン化合物
JP2005314355A (ja) * 2004-03-29 2005-11-10 Cambridge Univ Technical Services Ltd 化合物の合成方法および合成反応触媒
WO2005100354A1 (ja) 2004-04-12 2005-10-27 Eisai R & D Management Co., Ltd. ピラゾール縮合環誘導体の製造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MOLANDER, G. A. ET AL.: "Efficient Ligandless Palladium-Catalyzed Suzuki Reactions of Potassium Aryltrifluoroborates", ORGANIC LETTERS, vol. 4, no. 11, 2002, pages 1867 - 1870, XP008133101 *
N. MIYAURA; A. SUZUKI, CHEMICAL REVIEWS, vol. 95, 71119, pages 2457
See also references of EP2202233A4

Also Published As

Publication number Publication date
EP2202233A1 (en) 2010-06-30
US20100217001A1 (en) 2010-08-26
RU2010119706A (ru) 2011-11-27
IL204822A0 (en) 2010-11-30
CA2702958A1 (en) 2009-04-23
CN101827843A (zh) 2010-09-08
EP2202233A4 (en) 2010-11-10
BRPI0817839A2 (pt) 2015-06-16
MX2010004135A (es) 2010-04-30
JPWO2009051210A1 (ja) 2011-03-03

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