WO2009047654A1 - Low sodium salt replacing composition for use in food products, nutraceuticals and pharmaceuticals - Google Patents
Low sodium salt replacing composition for use in food products, nutraceuticals and pharmaceuticals Download PDFInfo
- Publication number
- WO2009047654A1 WO2009047654A1 PCT/IB2008/051470 IB2008051470W WO2009047654A1 WO 2009047654 A1 WO2009047654 A1 WO 2009047654A1 IB 2008051470 W IB2008051470 W IB 2008051470W WO 2009047654 A1 WO2009047654 A1 WO 2009047654A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition according
- acids
- sodium chloride
- sweeteners
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 235000013305 food Nutrition 0.000 title claims abstract description 19
- 239000002417 nutraceutical Substances 0.000 title claims abstract description 8
- 235000021436 nutraceutical agent Nutrition 0.000 title claims abstract description 7
- 239000003814 drug Substances 0.000 title description 5
- 159000000000 sodium salts Chemical class 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 68
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 50
- 239000011780 sodium chloride Substances 0.000 claims abstract description 36
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 25
- 239000001103 potassium chloride Substances 0.000 claims abstract description 25
- 239000000047 product Substances 0.000 claims abstract description 23
- 239000002253 acid Substances 0.000 claims abstract description 20
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 14
- 239000003765 sweetening agent Substances 0.000 claims abstract description 14
- 150000007513 acids Chemical class 0.000 claims abstract description 12
- 241000282414 Homo sapiens Species 0.000 claims abstract description 6
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 3
- 235000019658 bitter taste Nutrition 0.000 claims description 20
- 230000000873 masking effect Effects 0.000 claims description 15
- 235000019643 salty taste Nutrition 0.000 claims description 11
- 239000000654 additive Substances 0.000 claims description 9
- 235000016709 nutrition Nutrition 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 235000005985 organic acids Nutrition 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 208000037849 arterial hypertension Diseases 0.000 claims description 3
- 235000011194 food seasoning agent Nutrition 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000002787 reinforcement Effects 0.000 claims description 3
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 2
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims description 2
- 239000008122 artificial sweetener Substances 0.000 claims description 2
- 235000021311 artificial sweeteners Nutrition 0.000 claims description 2
- 230000037406 food intake Effects 0.000 claims description 2
- 235000012209 glucono delta-lactone Nutrition 0.000 claims description 2
- 239000000182 glucono-delta-lactone Substances 0.000 claims description 2
- 229960003681 gluconolactone Drugs 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- -1 malic Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000007246 mechanism Effects 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 229910001415 sodium ion Inorganic materials 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims description 2
- 150000008163 sugars Chemical class 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims 1
- 108010011485 Aspartame Proteins 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000004378 Glycyrrhizin Substances 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 244000228451 Stevia rebaudiana Species 0.000 claims 1
- 239000004376 Sucralose Substances 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 150000001279 adipic acids Chemical class 0.000 claims 1
- 239000000605 aspartame Substances 0.000 claims 1
- 235000010357 aspartame Nutrition 0.000 claims 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 1
- 229960003438 aspartame Drugs 0.000 claims 1
- 150000001559 benzoic acids Chemical class 0.000 claims 1
- 229940109275 cyclamate Drugs 0.000 claims 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims 1
- 239000005452 food preservative Substances 0.000 claims 1
- 235000019249 food preservative Nutrition 0.000 claims 1
- 150000002238 fumaric acids Chemical class 0.000 claims 1
- 150000002307 glutamic acids Chemical class 0.000 claims 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims 1
- 229960004949 glycyrrhizic acid Drugs 0.000 claims 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims 1
- 235000019410 glycyrrhizin Nutrition 0.000 claims 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims 1
- 230000009931 harmful effect Effects 0.000 claims 1
- 235000011167 hydrochloric acid Nutrition 0.000 claims 1
- 239000000832 lactitol Substances 0.000 claims 1
- 235000010448 lactitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 1
- 229960003451 lactitol Drugs 0.000 claims 1
- 150000002691 malonic acids Chemical class 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000002913 oxalic acids Chemical class 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 1
- 235000019204 saccharin Nutrition 0.000 claims 1
- 229940081974 saccharin Drugs 0.000 claims 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 229960002920 sorbitol Drugs 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 1
- 239000000892 thaumatin Substances 0.000 claims 1
- 235000010436 thaumatin Nutrition 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 description 29
- 239000000796 flavoring agent Substances 0.000 description 10
- 235000019634 flavors Nutrition 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 235000019640 taste Nutrition 0.000 description 8
- 230000001953 sensory effect Effects 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 229930006000 Sucrose Natural products 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 229930014626 natural product Natural products 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 230000006870 function Effects 0.000 description 4
- 235000019600 saltiness Nutrition 0.000 description 4
- 230000004872 arterial blood pressure Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000001096 (4-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol hydrochloride Substances 0.000 description 2
- NNKXWRRDHYTHFP-HZQSTTLBSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydron;dichloride Chemical compound Cl.Cl.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 NNKXWRRDHYTHFP-HZQSTTLBSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 229960001811 quinine hydrochloride Drugs 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 235000019596 Masking bitterness Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000019463 artificial additive Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000007211 cardiovascular event Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229960004667 ethyl cellulose Drugs 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021472 generally recognized as safe Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000019462 natural additive Nutrition 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 210000001779 taste bud Anatomy 0.000 description 1
- 235000019583 umami taste Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/40—Table salts; Dietetic salt substitutes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/40—Table salts; Dietetic salt substitutes
- A23L27/45—Salt substitutes completely devoid of sodium chloride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention is related to a composition to be used in food products, nutritional preparations, nutraceuticals and pharmaceuticals. More specifically, this invention is related to a composition with low or no sodium contents to be incorporated into food or the other abovementioned products, which has identical organoleptic properties to sodium chloride.
- Clinical trials of moderate reduction of sodium chloride intake show a cause-effect relationship with arterial pressure, without detection threshold; the previous effect has been validated for different ages, sex, ethnical origin, base arterial pressure and body mass.
- potassium chloride has been demonstrated to replace sodium chloride as seasoning, both at a culinary level as in industrial food production processes.
- Potassium chloride has no relation with arterial pressure and therefore, from a medicinal and nutritional perspective, is a good substitute of sodium chloride, having simultaneously some organoleptic characteristics that are similar to those of sodium chloride, e.g. a salty though less intense taste.
- potassium chloride has also negative organoleptic attributes, mainly a bitter taste that onsets along with the salty taste with a little delay (after taste).
- M. Koruda (US Patent 6,783,788) claims the formulation of a seasoning comprising potassium chloride and other additional products such as a sugar alcohol, sucrose, monosodium glutamate and inosinic and guanylic acid derivatives, the function of which is bitterness masking.
- E. Vasquez (US Patent 6,743,461) proposes the name of "table salt substitute” for a blend based on calcium chloride, potassium salts, citric acid, an additional product (filler), using rice flour to this end, and a combination of flavoring agents among which ginger oil and others stand out.
- W. R. Bonorden (US Patent 6,541,050) uses the name of "salt taste enhancing composition" for a mix of potassium and sodium chlorides that includes other sulfate derived salts (potassium and calcium) and calcium and magnesium chlorides.
- R. J. Kurz (US Patent 6,015,792) claims the use of some phenylalanine derivatives for masking or suppression of unpleasant tastes such as the bitterness of some products used in food manufacturing.
- nucleotides as additives is regulated in the maximum concentration to be added into food products. If the desired bitterness-masking effect does not occur within this limit, the procedure will have null value.
- the present invention provides a solution to these problems.
- the main object of the present invention is to provide a composition with low or no sodium content, with organoleptic characteristics identical to those of sodium chloride and thus being able to replace sodium chloride in its use as food seasoning.
- Another preferred object of the present invention is to achieve said organoleptic characteristics similar to those of sodium chloride with mixtures having different proportions of sodium and potassium chloride and the use of natural additives that also constitute or are part of usually consumed foods.
- Another object of the present invention is to provide a composition in which its flavor and other functional characteristics such as those mentioned earlier are stable in time, for prolonged time periods at room temperature.
- the preferred aspect that characterizes the present invention is the discovery of the fact that the bitter taste of potassium chloride can be masked with specific proportions of acids and sweeteners mixtures, in such a way that the organoleptic characteristics of the mixture make it undistinguishable from sodium chloride.
- Flavor-masking effects are well known in food technology, especially in literature related to the interaction of flavors and senses. It is well known that there are relevant interactions between the five basic tastes (salty, sweet, acid, bitter and umami), and that these interactions depend on the concentration of both products (masker and masked flavors). Flavor intensity also depends on particular subject's factors, such as age. There is a general flavor selectivity and intensity loss effect in human beings as age increase.
- bitter taste masking it is known that masking products identified with basic flavors such as sucrose (sweet) and citric acid (acid) cause individually an increase of the detection threshold of a bitter product such as, for example, quinine hydrochloride.
- the sensory detection threshold of the bitterness of quinine hydrochloride increases when this compound is mixed with increasing concentrations of citric acid or sucrose.
- the relationship between the detections threshold and the sucrose or citric acid concentration has an exponential form with an exponent around 0.4, which means, for example, that the concentration of the masking product should be raised around six times.
- One additional aspect of this invention is the fact that combinations of the cited products, besides attenuating completely the bitter taste, intensify the salty flavor of potassium chloride. Both effects occur simultaneously and at the same proportion between acid and sweet masking compositions, as will be evidenced in the application examples.
- the formulation that is an object of this privilege contains potassium chloride in a proportion comprised within the range from 5 to 100% by weight, individual organic acids or combinations of one or more of them in a proportion comprised within the range from 0.5 to 20% by weight, and a sweetener in a proportion comprised within the range from 0.5 to 18% by weight.
- this composition in the food field can be widened to the drink and nutritional preparation fields, and also to the formulation of the so-called nutraceutical products and those pharmaceutical products that use sodium chloride with sensory purposes.
- Potassium chloride is dry-mixed with different proportions of sucrose and a combination of ascorbic and tartaric acids with a 2:1 ratio, thus preparing sixteen samples having different proportions of the indicated ingredients.
- Each sample is separately mixed and homogenized, and subsequently it is subjected to a comparative bitterness and saltiness test by a previously trained sensory panel. Both organoleptically determined bitterness and saltiness were adjusted to a scale from zero to one hundred points, wherein the maximum value corresponds to the most intense sensation.
- Each sample is evaluated by triplicate and the number indicated in the table is the arithmetical average of the three evaluations. The composition for each sample and the evaluation results are presented in the following table.
- bitter taste A similar situation is observed for the bitter taste, starting from a value of 84.5 for potassium chloride alone.
- proportions of acid and sweetener increase, a point is reached where bitterness is comparable to that of sodium chloride alone.
- the effect reverts and the product becomes bitterer.
- Example 1 A similar trend to Example 1 can be observed in this Example, i.e. when incrementing the additive proportion (sweeteners and acids) a point is reached where the bitter taste is maximally inhibited simultaneously with a maximum reinforcement of the salty taste, which corresponds to sample 22 in this Example.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Seasonings (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08737891A EP2211638A1 (en) | 2007-10-10 | 2008-04-17 | Low sodium salt replacing composition for use in food products, nutraceuticals and pharmaceuticals |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2915-2007 | 2007-10-10 | ||
| CL200702915A CL2007002915A1 (es) | 2007-10-10 | 2007-10-10 | Composicion para alimentos, suplementos nutritivos, productos nutraceuticos u otros de consumo humano que comprende cloruro de sodio, cloruro de potasio, acidos y edulcorantes, donde las proporciones de dichos componentes confieren a la composicion p |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2009047654A1 true WO2009047654A1 (en) | 2009-04-16 |
Family
ID=40261524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2008/051470 WO2009047654A1 (en) | 2007-10-10 | 2008-04-17 | Low sodium salt replacing composition for use in food products, nutraceuticals and pharmaceuticals |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2211638A1 (es) |
| AR (1) | AR063891A1 (es) |
| CL (1) | CL2007002915A1 (es) |
| WO (1) | WO2009047654A1 (es) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011040505A1 (ja) * | 2009-10-02 | 2011-04-07 | ハウス食品株式会社 | 塩味が補強又は増強された食品組成物及び異味が抑制された塩化カリウム含有組成物 |
| WO2014124214A1 (en) * | 2013-02-08 | 2014-08-14 | General Mills, Inc. | Reduced sodium food products |
| US9247762B1 (en) | 2014-09-09 | 2016-02-02 | S & P Ingredient Development, Llc | Salt substitute with plant tissue carrier |
| US9549568B2 (en) | 2006-10-05 | 2017-01-24 | S & P Ingredient Development, Llc | Low sodium salt composition |
| US9629384B2 (en) | 2005-09-14 | 2017-04-25 | S & P Ingredient Development, Llc | Low sodium salt composition |
| US11051539B2 (en) | 2017-09-18 | 2021-07-06 | S & P Ingredient Development, Llc | Low sodium salt substitute with potassium chloride |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2968566A (en) | 1959-01-07 | 1961-01-17 | Pharmacodynamics Inc | Composition useful with comestibles |
| US4243691A (en) | 1979-05-18 | 1981-01-06 | The Procter & Gamble Company | Sodium-free salt substitute |
| EP0124254A1 (en) | 1983-03-30 | 1984-11-07 | NABISCO BRANDS, Inc. | Salt substitute composition |
| JPS623758A (ja) | 1985-06-28 | 1987-01-09 | Ajinomoto Co Inc | 風味調味料 |
| EP0291980A1 (en) | 1987-05-20 | 1988-11-23 | Chugai Seiyaku Kabushiki Kaisha | Salt substitute and foodstuffs containing same |
| EP0809942A1 (en) | 1996-05-28 | 1997-12-03 | Dead Sea Works Ltd | Low sodium edible salt mixture |
| US6541050B1 (en) | 1998-11-27 | 2003-04-01 | Campbell Soup Company | Salt flavor enhancing compositions, food products including such compositions, and methods for preparing such products |
| US6743461B1 (en) | 2001-11-09 | 2004-06-01 | Ecosalt Corporation | Salt substitute compositions |
| US6783788B2 (en) | 2001-02-09 | 2004-08-31 | Ajinomoto Co., Inc. | Seasoning compositions, foods containing such a seasoning composition, and process for preparing such foods |
| US7056534B2 (en) | 2001-10-23 | 2006-06-06 | Upsher-Smith Laboratories, Inc. | Coated potassium chloride granules and tablets |
-
2007
- 2007-10-10 CL CL200702915A patent/CL2007002915A1/es unknown
- 2007-11-21 AR ARP070105178A patent/AR063891A1/es unknown
-
2008
- 2008-04-17 WO PCT/IB2008/051470 patent/WO2009047654A1/en active Application Filing
- 2008-04-17 EP EP08737891A patent/EP2211638A1/en not_active Withdrawn
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2968566A (en) | 1959-01-07 | 1961-01-17 | Pharmacodynamics Inc | Composition useful with comestibles |
| US4243691A (en) | 1979-05-18 | 1981-01-06 | The Procter & Gamble Company | Sodium-free salt substitute |
| EP0124254A1 (en) | 1983-03-30 | 1984-11-07 | NABISCO BRANDS, Inc. | Salt substitute composition |
| JPS623758A (ja) | 1985-06-28 | 1987-01-09 | Ajinomoto Co Inc | 風味調味料 |
| EP0291980A1 (en) | 1987-05-20 | 1988-11-23 | Chugai Seiyaku Kabushiki Kaisha | Salt substitute and foodstuffs containing same |
| EP0809942A1 (en) | 1996-05-28 | 1997-12-03 | Dead Sea Works Ltd | Low sodium edible salt mixture |
| US6541050B1 (en) | 1998-11-27 | 2003-04-01 | Campbell Soup Company | Salt flavor enhancing compositions, food products including such compositions, and methods for preparing such products |
| US6783788B2 (en) | 2001-02-09 | 2004-08-31 | Ajinomoto Co., Inc. | Seasoning compositions, foods containing such a seasoning composition, and process for preparing such foods |
| US7056534B2 (en) | 2001-10-23 | 2006-06-06 | Upsher-Smith Laboratories, Inc. | Coated potassium chloride granules and tablets |
| US6743461B1 (en) | 2001-11-09 | 2004-06-01 | Ecosalt Corporation | Salt substitute compositions |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9629384B2 (en) | 2005-09-14 | 2017-04-25 | S & P Ingredient Development, Llc | Low sodium salt composition |
| US9549568B2 (en) | 2006-10-05 | 2017-01-24 | S & P Ingredient Development, Llc | Low sodium salt composition |
| WO2011040505A1 (ja) * | 2009-10-02 | 2011-04-07 | ハウス食品株式会社 | 塩味が補強又は増強された食品組成物及び異味が抑制された塩化カリウム含有組成物 |
| JP5739343B2 (ja) * | 2009-10-02 | 2015-06-24 | ハウス食品グループ本社株式会社 | 塩味が補強又は増強された食品組成物及び異味が抑制された塩化カリウム含有組成物 |
| JP2015130892A (ja) * | 2009-10-02 | 2015-07-23 | ハウス食品グループ本社株式会社 | 塩味が補強又は増強されたソースを作るためのルウ及び異味が抑制された塩化カリウムを含有するソースを作るためのルウ |
| JP2017131247A (ja) * | 2009-10-02 | 2017-08-03 | ハウス食品グループ本社株式会社 | 異味が抑制された塩化カリウムを含有するソースを作るためのルウ |
| WO2014124214A1 (en) * | 2013-02-08 | 2014-08-14 | General Mills, Inc. | Reduced sodium food products |
| US10159268B2 (en) | 2013-02-08 | 2018-12-25 | General Mills, Inc. | Reduced sodium food products |
| US11540539B2 (en) | 2013-02-08 | 2023-01-03 | General Mills, Inc. | Reduced sodium food products |
| US9247762B1 (en) | 2014-09-09 | 2016-02-02 | S & P Ingredient Development, Llc | Salt substitute with plant tissue carrier |
| US11051539B2 (en) | 2017-09-18 | 2021-07-06 | S & P Ingredient Development, Llc | Low sodium salt substitute with potassium chloride |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2211638A1 (en) | 2010-08-04 |
| AR063891A1 (es) | 2009-02-25 |
| CL2007002915A1 (es) | 2008-04-25 |
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