Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
  • G01N30/02—Column chromatography
  • G01N30/04—Preparation or injection of sample to be analysed
  • G01N30/16—Injection
  • G01N30/18—Injection using a septum or microsyringe
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
  • G01N30/02—Column chromatography
  • G01N30/04—Preparation or injection of sample to be analysed
  • G01N30/16—Injection
  • G01N30/20—Injection using a sampling valve

Definitions

• the invention relates to an injection port for analyzers, in which a sample to be analyzed is delivered by means of a sample dispenser in an analysis chamber.
• the invention also relates to an arrangement for actuating the injection port and provided with a corresponding injection port analyzer.
• a liquid sample to be analyzed is usually aspirated automatically by means of a sampler from a vessel containing the sample to be analyzed by means of a cannula and, after appropriate repositioning of the sampler, into the analysis chamber, e.g. may be a reactor in which the sample is evaporated, injected and then analyzed.
• the analysis chamber be exposed to ambient air only to a limited extent before, during and after the analysis.
• ambient air before analysis not in the
• the analysis chamber Penetrate the analysis chamber and may falsify the measurement if necessary. If the sample to be analyzed in the analysis chamber evaporated, the resulting gases should be as completely as possible corresponding sensors supplied and not escape uncontrolled into the environment. After analysis, the analysis chamber can be rinsed, for example, with an inert gas, which should also not escape uncontrollably into the environment. On the other hand, the cannula of a sample dispenser must be able to be introduced into the analysis chamber, so that an access for the cannula to the analysis chamber is needed.
• the invention has for its object to provide an injection port for analyzers and provided with a corresponding injection port analyzer, in which the desired lockable access for a cannula of a sampler realized septumok and the maintenance is significantly reduced.
• the invention is also based on the object of specifying an arrangement for actuating the injection port according to the invention, by means of which a particularly safe and economical operation of the injection port can be ensured.
• the invention has the great advantage that by means of a controlled open and close elastic valve element, the access of the cannula to the analysis chamber can be sealed both in the absence of cannula as well as inserted cannula.
• the valve element can be opened so far that the cannula passes without contact through the injection port, so that it comes to no abrasion and the valve element can have very long service life.
• Fig. 1 shows a highly schematic side sectional view of an injection port according to the invention.
• Fig. 2 shows the injection port of FIG. 1 in a schematic plan view, without O-ring and hose adapter.
• Fig. 3 shows schematically a system for controlled opening
• a designated in its entirety by 10 injection port is shown, which in this embodiment has a two-part housing with a housing upper part 12 and a lower housing part 14.
• the lower housing part 14 is provided with a connection in the form of a so-called Luerkegels 16, by means of which it can be connected to an analysis chamber of an analysis device not shown here.
• the housing lower part 12 also has a terminal 18, via which the
• Injection port can be connected to a pressure source, in particular a compressed air source.
• a pressure source in particular a compressed air source.
• the interior of the housing thus forms a pressurizable chamber within the meaning of claim 4.
• an inlet in the form of a conically tapering and thus a centering aid forming opening 20 is provided for a cannula of a sampler known per se not shown here.
• the luer cone 16 has a through hole 22 which opens into an outlet for the cannula and which is located in the housing upper part 12 in extension of the opening 20.
• the upper housing part 12 is gas-tight screwed onto the lower housing part 14 in this embodiment, including in this embodiment
• Section of the housing lower part 14 with an external thread and a portion of the housing upper part 12 are provided with a complementary internal thread.
• other types of attachment between the housing parts e.g. a flange connection.
• the screw connection shown from the upper housing part 12 and lower housing part 14 has the great advantage, on the one hand cost and without further connecting parts feasible, on the other hand to be easily detachable, so that by unscrewing the upper housing part 12 access to the arranged in the housing parts of the injection port is possible.
• the housing 16 is an elastic between the inlet 20 and the luer cone
• Valve element here in the form of a piece of tubing 24, by means of a support tube 26, two provided at the two open ends of the support tube 26 hose adapter 28 and two provided between the hose adapters 28 and the housing O-rings 30 arranged such that the hose piece 24 in its longitudinal direction can be traversed by a guided through the opening 20 to the luer cone 16 cannula of a sample dispenser.
• a support tube 26 two provided at the two open ends of the support tube 26
• hose adapter 28 and two provided between the hose adapters 28 and the housing O-rings 30 arranged such that the hose piece 24 in its longitudinal direction can be traversed by a guided through the opening 20 to the luer cone 16 cannula of a sample dispenser.
• the piece of tubing 24 is exposed directly to the pressure prevailing in the housing pressure conditions.
• the hose adapter 28 and the O-rings 30 seal together with the hose piece 24 the housing interior relative to the housing outside, so that, for example, a gas or a fluid over the terminal 18 is passed into the housing interior, not via the opening 20 or the bore 22 can escape.
• This embodiment makes it possible to squeeze the tube piece 24 by increasing the internal pressure in the housing such that the access formed by the injection port to an analysis chamber of an analyzer, not shown here, is sealed in such a way that neither ambient air penetrates into the analysis chamber nor, for example, during an analysis Resulting gases from the analysis chamber can penetrate beyond the injection port.
• the access can be closed both in case of missing as well as guided through the injection port cannula of a sample dispenser, in the latter case, the tube rests close to the cannula outside and the
• Analyzer chamber is of course connected via the cannula with the sampler, which, however, is usually itself designed so that no gases can escape from the analysis chamber uncontrolled about him.
• the inner diameter of the tube piece 24 is advantageously dimensioned so that it is slightly larger than the outer diameter of a commonly used cannula. This then makes it possible to pass the cannula without contact through the tube piece when it is not pressurized. This results in no abrasion, which extends the life of the hose piece considerably. That in this embodiment, the analysis chamber during insertion of the cannula is not sealed gas-tight by the injection port for a short time, does not hurt in most applications. If a gas-tight seal is also desired during insertion of the cannula, the pressure inside the housing can be reduced so that the tube piece bears against the cannula during insertion but does not result in excessive frictional forces between cannula and tube piece.
• FIG. 3 schematically shows a possible arrangement for actuating the injection port 10, or more precisely, a valve element provided in the injection port.
• the arrangement comprises a pressure source, here in the form of a compressed air tank 40, which is connected via a flow restrictor, here in the form of a capillary 42, a buffer tank 44 and a 3/2-way valve 46 to the port 18 of the injection port 10.
• a pressure source here in the form of a compressed air tank 40
• a flow restrictor here in the form of a capillary 42
• a buffer tank 44 and a 3/2-way valve 46 to the port 18 of the injection port 10.
• the 3/2-way valve and a corresponding, known per se control provided in the injection port 10 elastic valve element so for example, the hose piece shown in FIG. 1 are pressurized or relieved so that the valve element opens or closes.
• the supply can be done via the buffer tank 44, which allows it together with the flow restrictor 42 to protect the assembly against excessive compressed air consumption at eg defective elastic valve element in the injection port.
• the buffer tank which in the dimensions of the injection port for usual
• Analyzers approximately has a volume of 100 ml, is refilled via the flow restrictor only with a very limited flow. This can ensure that e.g. If the valve element in the injection port is defective, an air quantity of a maximum of only about 30 l per hour escapes.
• valve element used. So it is e.g. possible, instead of the hose piece shown, which is squeezed together by external pressure in the desired manner, to use an elastic double-walled tubular element which is inflated or with a
• Fluid is filled, that reduces its inner diameter in the desired manner, so as to close the access with or without cannula to a injection port downstream analysis chamber. It is also possible to use the hose piece in place of the open support tube shown e.g. to clamp in a U-profile. It is further clear to the person skilled in the art that the desired effect of the
• Opening and closing of the elastic valve element also results when the valve element is acted upon instead of compressed air or another gas with a fluid.
• a compressed air source is available on an analyzer of the type in question, so that it can be used advantageously for actuating the valve element of the injection sport.

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• Physics & Mathematics (AREA)
• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Analytical Chemistry (AREA)
• Biochemistry (AREA)
• General Health & Medical Sciences (AREA)
• General Physics & Mathematics (AREA)
• Immunology (AREA)
• Pathology (AREA)
• Sampling And Sample Adjustment (AREA)

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Citations (9)

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• 2007
  • 2007-08-02 DE DE102007036612A patent/DE102007036612A1/de not_active Withdrawn
• 2008
  • 2008-08-01 EP EP08801097.0A patent/EP2174125B1/de active Active
  • 2008-08-01 PL PL08801097T patent/PL2174125T3/pl unknown
  • 2008-08-01 US US12/671,699 patent/US8677844B2/en active Active
  • 2008-08-01 WO PCT/DE2008/001259 patent/WO2009015656A1/de not_active Ceased
  • 2008-08-01 JP JP2010518493A patent/JP2010535327A/ja active Pending

Patent Citations (9)

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