WO2009004842A1 - ブタ浮腫病ワクチン - Google Patents

ブタ浮腫病ワクチン Download PDF

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Publication number
WO2009004842A1
WO2009004842A1 PCT/JP2008/055550 JP2008055550W WO2009004842A1 WO 2009004842 A1 WO2009004842 A1 WO 2009004842A1 JP 2008055550 W JP2008055550 W JP 2008055550W WO 2009004842 A1 WO2009004842 A1 WO 2009004842A1
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
edema disease
plant
swine edema
swine
Prior art date
Application number
PCT/JP2008/055550
Other languages
English (en)
French (fr)
Inventor
Kazutoshi Sawada
Takeshi Matsui
Sou-Ichi Makino
Keiko Kawamoto
Kazuya Yoshida
Original Assignee
Idemitsu Kosan Co., Ltd.
National University Corporation NARA Institute of Science and Technology
National University Corporation Obihiro University Of Agriculture And Veterinary Medicine
Yoshida, Mayumi
Yoshida, Nobuo
Yoshida, Kyoko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idemitsu Kosan Co., Ltd., National University Corporation NARA Institute of Science and Technology, National University Corporation Obihiro University Of Agriculture And Veterinary Medicine, Yoshida, Mayumi, Yoshida, Nobuo, Yoshida, Kyoko filed Critical Idemitsu Kosan Co., Ltd.
Priority to ES08722760.9T priority Critical patent/ES2564685T3/es
Priority to US12/667,393 priority patent/US9080180B2/en
Priority to CN200880023029.4A priority patent/CN101868540B/zh
Priority to JP2009521546A priority patent/JP5279089B2/ja
Priority to DK08722760.9T priority patent/DK2169054T3/en
Priority to EP08722760.9A priority patent/EP2169054B1/en
Publication of WO2009004842A1 publication Critical patent/WO2009004842A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/517—Plant cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

　ブタ浮腫病ワクチンを低コストかつ高効率に生産する技術を開発する。具体的にはブタ浮腫病の毒素タンパク質（Ｓｔｘ２ｅタンパク質）の遺伝子を植物細胞で効率良く発現させ、低コストにブタ浮腫病の植物ワクチンを生産する。植物由来の分泌シグナルペプチドがアミノ末端に付加されたＳｔｘ２ｅタンパク質を、植物由来のアルコールデヒドロゲナーゼ遺伝子の５'－非翻訳領域（ＡＤＨ５’ＵＴＲ）を用いて、レタス等の植物細胞で発現させる。
PCT/JP2008/055550 2007-07-03 2008-03-25 ブタ浮腫病ワクチン WO2009004842A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES08722760.9T ES2564685T3 (es) 2007-07-03 2008-03-25 Vacuna contra la enfermedad de edema porcino
US12/667,393 US9080180B2 (en) 2007-07-03 2008-03-25 Transgenic plants expressing STX2EB protein for use as a pig edema disease vaccine
CN200880023029.4A CN101868540B (zh) 2007-07-03 2008-03-25 猪浮肿病疫苗
JP2009521546A JP5279089B2 (ja) 2007-07-03 2008-03-25 ブタ浮腫病ワクチン
DK08722760.9T DK2169054T3 (en) 2007-07-03 2008-03-25 A vaccine against edema disease in swine
EP08722760.9A EP2169054B1 (en) 2007-07-03 2008-03-25 Pig edema disease vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-174919 2007-07-03
JP2007174919 2007-07-03

Publications (1)

Publication Number Publication Date
WO2009004842A1 true WO2009004842A1 (ja) 2009-01-08

Family

ID=40225903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055550 WO2009004842A1 (ja) 2007-07-03 2008-03-25 ブタ浮腫病ワクチン

Country Status (10)

Country Link
US (1) US9080180B2 (ja)
EP (1) EP2169054B1 (ja)
JP (1) JP5279089B2 (ja)
KR (1) KR20100044813A (ja)
CN (1) CN101868540B (ja)
AR (1) AR067417A1 (ja)
DK (1) DK2169054T3 (ja)
ES (1) ES2564685T3 (ja)
TW (1) TWI456061B (ja)
WO (1) WO2009004842A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009133882A1 (ja) 2008-05-02 2009-11-05 出光興産株式会社 細菌毒素ワクチン
JP2012019719A (ja) * 2010-07-13 2012-02-02 Idemitsu Kosan Co Ltd 糖鎖修飾が抑制された改変Ｓｔｘ２ｅタンパク質
WO2015080099A1 (ja) 2013-11-26 2015-06-04 出光興産株式会社 大腸菌性下痢症の予防
WO2015080100A1 (ja) 2013-11-26 2015-06-04 出光興産株式会社 大腸菌症用ワクチン
WO2016021276A1 (ja) * 2014-08-08 2016-02-11 出光興産株式会社 豚繁殖・呼吸障害症候群防除剤
CN107625960A (zh) * 2017-09-22 2018-01-26 江苏省农业科学院 一种通用型猪大肠杆菌病疫苗及其制备方法

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US9787725B2 (en) * 2011-01-21 2017-10-10 Qualcomm Incorporated User input back channel for wireless displays
CN102580071A (zh) * 2012-02-28 2012-07-18 青岛易邦生物工程有限公司 仔猪水肿病毒素亚单位灭活疫苗的制备方法
KR20160133120A (ko) 2015-05-12 2016-11-22 (주)애드바이오텍 IgY 함유 돼지부종병 예방용 사료 또는 사료 첨가제
KR102103013B1 (ko) * 2019-10-30 2020-04-21 전북대학교산학협력단 Stx2eA-C-말단 단편-Stx2eB-오량체 재조합 단백질； 및 F4를 발현하는 장관독소형 대장균 및 F18을 발현하는 장관독소형 대장균 사균체 혼합 항원을 포함하는 돼지의 병원성 대장균증의 예방 또는 치료용 백신 조성물

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009133882A1 (ja) 2008-05-02 2009-11-05 出光興産株式会社 細菌毒素ワクチン
EP2728004A2 (en) 2008-05-02 2014-05-07 Idemitsu Kosan Co., Ltd. Bacterial toxin vaccine
JP2012019719A (ja) * 2010-07-13 2012-02-02 Idemitsu Kosan Co Ltd 糖鎖修飾が抑制された改変Ｓｔｘ２ｅタンパク質
WO2015080099A1 (ja) 2013-11-26 2015-06-04 出光興産株式会社 大腸菌性下痢症の予防
WO2015080100A1 (ja) 2013-11-26 2015-06-04 出光興産株式会社 大腸菌症用ワクチン
KR20160089412A (ko) 2013-11-26 2016-07-27 이데미쓰 고산 가부시키가이샤 대장균성 설사증의 예방
JPWO2015080099A1 (ja) * 2013-11-26 2017-03-16 出光興産株式会社 大腸菌性下痢症の予防
US9937271B2 (en) 2013-11-26 2018-04-10 Idemitsu Kosan Co., Ltd. Prevention of Escherichia coli diarrhea
WO2016021276A1 (ja) * 2014-08-08 2016-02-11 出光興産株式会社 豚繁殖・呼吸障害症候群防除剤
CN107625960A (zh) * 2017-09-22 2018-01-26 江苏省农业科学院 一种通用型猪大肠杆菌病疫苗及其制备方法

Also Published As

Publication number Publication date
JP5279089B2 (ja) 2013-09-04
US9080180B2 (en) 2015-07-14
KR20100044813A (ko) 2010-04-30
TWI456061B (zh) 2014-10-11
DK2169054T3 (en) 2016-03-07
TW200914611A (en) 2009-04-01
EP2169054A4 (en) 2010-06-02
AR067417A1 (es) 2009-10-07
EP2169054A1 (en) 2010-03-31
CN101868540A (zh) 2010-10-20
US20110002950A1 (en) 2011-01-06
CN101868540B (zh) 2014-11-26
EP2169054B1 (en) 2015-12-23
ES2564685T3 (es) 2016-03-28
JPWO2009004842A1 (ja) 2010-08-26

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