WO2008155999A1 - Ｇａｂａ作動性ニューロン賦活剤 - Google Patents

Ｇａｂａ作動性ニューロン賦活剤 Download PDF

Info

Publication number
WO2008155999A1
WO2008155999A1 PCT/JP2008/060478 JP2008060478W WO2008155999A1 WO 2008155999 A1 WO2008155999 A1 WO 2008155999A1 JP 2008060478 W JP2008060478 W JP 2008060478W WO 2008155999 A1 WO2008155999 A1 WO 2008155999A1
Authority
WO
WIPO (PCT)
Prior art keywords
gabaergic neuron
activator
gabaergic
neuron activator
food
Prior art date
Application number
PCT/JP2008/060478
Other languages
English (en)
French (fr)
Inventor
Eiji Takeda
Junji Terao
Hiroyoshi Sei
Hiroyuki Sakakibara
Kazuyoshi Kitaoka
Toshitsugu Miyazaki
Chieko Kitajima
Original Assignee
Nagase & Co., Ltd.
The University Of Tokushima
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nagase & Co., Ltd., The University Of Tokushima filed Critical Nagase & Co., Ltd.
Priority to JP2009520424A priority Critical patent/JP5204771B2/ja
Publication of WO2008155999A1 publication Critical patent/WO2008155999A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Psychiatry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Physiology (AREA)
  • Animal Husbandry (AREA)

Abstract

　安全性に優れ、かつ、ＧＡＢＡ作動性ニューロンを賦活し得るＧＡＢＡ作動性ニューロン賦活剤を提供する。 　本発明のＧＡＢＡ作動性ニューロン賦活剤は、醗酵人参エキスを有効成分として含有する。本発明の睡眠障害の予防または治療のために用いられる旨の表示を付した飲食物は、該ＧＡＢＡ作動性ニューロン賦活剤を含有し、ＧＡＢＡ作動性ニューロン賦活作用を有することを特徴とする。
PCT/JP2008/060478 2007-06-21 2008-06-06 Ｇａｂａ作動性ニューロン賦活剤 WO2008155999A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009520424A JP5204771B2 (ja) 2007-06-21 2008-06-06 Ｇａｂａ作動性ニューロン賦活剤

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007164115 2007-06-21
JP2007-164115 2007-06-21
JP2007-196222 2007-07-27
JP2007196222 2007-07-27

Publications (1)

Publication Number Publication Date
WO2008155999A1 true WO2008155999A1 (ja) 2008-12-24

Family

ID=40156158

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060478 WO2008155999A1 (ja) 2007-06-21 2008-06-06 Ｇａｂａ作動性ニューロン賦活剤

Country Status (2)

Country Link
JP (1) JP5204771B2 (ja)
WO (1) WO2008155999A1 (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012527233A (ja) * 2009-05-19 2012-11-08 イル・ファ・カンパニー・リミテッド 発酵高麗人参濃縮液または粉末の製造方法
CN103169787A (zh) * 2012-11-30 2013-06-26 云南白药天颐茶品有限公司 一种具有提高睡眠质量延长深度睡眠时间的组合物及其应用
JP2013529899A (ja) * 2010-05-14 2013-07-25 株式会社ジーシーエイチアンドピー ジンセノサイド成分を増加させた新規な加工人参または加工人参抽出物の製造方法
JP2015168614A (ja) * 2014-03-04 2015-09-28 長瀬産業株式会社 Ｇｌｐ−１分泌促進剤
KR20160130779A (ko) 2014-03-25 2016-11-14 가부시키가이샤 야쿠르트 혼샤 수면의 질 개선제
WO2017047777A1 (ja) * 2015-09-18 2017-03-23 国立大学法人徳島大学 ストレス負荷解放後のセロトニン欠乏改善剤
WO2017047776A1 (ja) * 2015-09-18 2017-03-23 国立大学法人徳島大学 血中トリプトファン濃度上昇抑制剤
CN107375374A (zh) * 2017-08-21 2017-11-24 东方红（通化）生物医药股份有限公司 一种具有辅助改善睡眠作用的西洋参/人参提取物的发酵提取方法
JP2017222601A (ja) * 2016-06-15 2017-12-21 国立大学法人広島大学 神経変性疾患治療剤
CN108042592A (zh) * 2018-02-09 2018-05-18 云南三七科技有限公司 一种熟三七饮片的制备方法
WO2018123910A1 (ja) * 2016-12-28 2018-07-05 小林製薬株式会社 男性ホルモン増加促進用組成物
CN109715177A (zh) * 2016-03-14 2019-05-03 赫罗微生物群公司 调节消化道微生物组以治疗精神病或中枢神经系统疾病
US10709749B2 (en) 2013-08-30 2020-07-14 Green Cross Wellbeing Corporation Composition for preventing and treating cancer-related fatigue, containing processed ginseng powder or processed ginseng extract having increased ginsenoside constituent

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6450878B1 (ja) * 2018-03-28 2019-01-09 株式会社ナガセビューティケァ 発酵物の製造方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09176017A (ja) * 1995-12-27 1997-07-08 Happy World:Kk 制癌剤
JPH10212296A (ja) * 1997-01-29 1998-08-11 Happy World:Kk 糖尿病に伴う腎疾患治療剤
JP2004049154A (ja) * 2002-07-23 2004-02-19 Hideo Hasegawa サポニン分解物を含む発酵人参およびその製造方法
CN1895256A (zh) * 2006-06-09 2007-01-17 上海中药创新研究中心 20(s)－原人参二醇在制备抗抑郁药物中的应用
CN1931177A (zh) * 2006-09-21 2007-03-21 上海中药创新研究中心 20(s)－原人参二醇衍生物在制备抗抑郁药物中的应用
KR20070052256A (ko) * 2007-05-03 2007-05-21 홍림통산(주) 유산균으로 감마-아미노부틸산과 생물전환 사포닌을 동시에강화한 발효 인삼 조성물

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09176017A (ja) * 1995-12-27 1997-07-08 Happy World:Kk 制癌剤
JPH10212296A (ja) * 1997-01-29 1998-08-11 Happy World:Kk 糖尿病に伴う腎疾患治療剤
JP2004049154A (ja) * 2002-07-23 2004-02-19 Hideo Hasegawa サポニン分解物を含む発酵人参およびその製造方法
CN1895256A (zh) * 2006-06-09 2007-01-17 上海中药创新研究中心 20(s)－原人参二醇在制备抗抑郁药物中的应用
CN1931177A (zh) * 2006-09-21 2007-03-21 上海中药创新研究中心 20(s)－原人参二醇衍生物在制备抗抑郁药物中的应用
KR20070052256A (ko) * 2007-05-03 2007-05-21 홍림통산(주) 유산균으로 감마-아미노부틸산과 생물전환 사포닌을 동시에강화한 발효 인삼 조성물

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HASEGAWA H.: "Probiotics no Kino to Sayo Kanpo to Probiotics", SHUKAN IGAKU NO AYUMI, vol. 207, no. 10, 2003, pages 857 - 861 *
KIMURA T. ET AL.: "Interactions of Ginsenosides with Ligand-bindings of GABAA and GABAB Receptors", GEN. PHARMACOL., vol. 25, no. 1, 1994, pages 193 - 199, XP023803990 *
TACHIKAWA E. ET AL.: "Effects of ginseng saponins on responses induced by various receptor stimuli", EUR. J. PHARMACOL., vol. 369, no. 1, 1999, pages 23 - 32 *

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012527233A (ja) * 2009-05-19 2012-11-08 イル・ファ・カンパニー・リミテッド 発酵高麗人参濃縮液または粉末の製造方法
US9512453B2 (en) 2010-05-14 2016-12-06 Green Cross Wellbeing Corporation Method for preparing novel processed ginseng or an extract thereof, the usually minute ginsenoside content of which is increased
JP2013529899A (ja) * 2010-05-14 2013-07-25 株式会社ジーシーエイチアンドピー ジンセノサイド成分を増加させた新規な加工人参または加工人参抽出物の製造方法
CN103169787B (zh) * 2012-11-30 2014-11-26 云南白药天颐茶品有限公司 一种具有提高睡眠质量延长深度睡眠时间的组合物及其应用
CN103169787A (zh) * 2012-11-30 2013-06-26 云南白药天颐茶品有限公司 一种具有提高睡眠质量延长深度睡眠时间的组合物及其应用
US11464821B2 (en) 2013-08-30 2022-10-11 Green Cross Wellbeing Corporation Composition for reducing cancer cachexia or weight loss caused by anticancer drug therapy or radiation therapy comprising ginseng extract having increased ginsenoside Rg3 and Rh2
US10709749B2 (en) 2013-08-30 2020-07-14 Green Cross Wellbeing Corporation Composition for preventing and treating cancer-related fatigue, containing processed ginseng powder or processed ginseng extract having increased ginsenoside constituent
JP2015168614A (ja) * 2014-03-04 2015-09-28 長瀬産業株式会社 Ｇｌｐ−１分泌促進剤
KR20160130779A (ko) 2014-03-25 2016-11-14 가부시키가이샤 야쿠르트 혼샤 수면의 질 개선제
US11331353B2 (en) 2014-03-25 2022-05-17 Kabushiki Kaisha Yakult Honsha Sleep quality improver
JPWO2017047776A1 (ja) * 2015-09-18 2018-07-12 国立大学法人徳島大学 血中トリプトファン濃度上昇抑制剤
WO2017047777A1 (ja) * 2015-09-18 2017-03-23 国立大学法人徳島大学 ストレス負荷解放後のセロトニン欠乏改善剤
WO2017047776A1 (ja) * 2015-09-18 2017-03-23 国立大学法人徳島大学 血中トリプトファン濃度上昇抑制剤
JPWO2017047777A1 (ja) * 2015-09-18 2018-07-12 国立大学法人徳島大学 ストレス負荷解放後のセロトニン欠乏改善剤
CN109715177A (zh) * 2016-03-14 2019-05-03 赫罗微生物群公司 调节消化道微生物组以治疗精神病或中枢神经系统疾病
JP2017222601A (ja) * 2016-06-15 2017-12-21 国立大学法人広島大学 神経変性疾患治療剤
WO2018123910A1 (ja) * 2016-12-28 2018-07-05 小林製薬株式会社 男性ホルモン増加促進用組成物
US11253532B2 (en) 2016-12-28 2022-02-22 Kobayashi Pharmaceutical Co., Ltd. Composition for promoting increase in androgen
CN107375374A (zh) * 2017-08-21 2017-11-24 东方红（通化）生物医药股份有限公司 一种具有辅助改善睡眠作用的西洋参/人参提取物的发酵提取方法
CN108042592A (zh) * 2018-02-09 2018-05-18 云南三七科技有限公司 一种熟三七饮片的制备方法

Also Published As

Publication number Publication date
JPWO2008155999A1 (ja) 2010-08-26
JP5204771B2 (ja) 2013-06-05

Similar Documents

Publication Publication Date Title
WO2008155999A1 (ja) Ｇａｂａ作動性ニューロン賦活剤
WO2008023266A3 (en) Kiwi extract
EP1767212A4 (en) USE OF A PLANT OF THE GENUS AMPELOPSIS AND EXTRACTS OF THIS PLANT FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A FUNCTIONAL FOOD
WO2010002283A3 (en) New insulin analogues of prolonged activity
WO2007146411A3 (en) Nanoshell therapy
WO2010060937A3 (en) Pharmaceutical combination comprising a hsp 90 inhibitor and a mtor inhibitor
WO2005097119A3 (en) Pten inhibitors
WO2012087047A3 (en) Percutaneous absorption preparation containing rivastigmine
WO2010088450A3 (en) Arylamide derivatives useful in the treatment of diseases associated with serca activity
WO2006085115A3 (en) Therapeutic uses of tomato extracts
WO2008155998A1 (ja) 抗不安抗うつ剤
WO2008070859A3 (en) Treatment of skin conditions by dickkopf1 (dkk1)
WO2009078447A1 (ja) 抗ノロウイルス剤、抗インフルエンザウイルス剤、およびこれらを用いた抗ウイルス処理方法
WO2008096203A3 (en) Food extracts containing n-methylnicotinamide for treatment of lipoprotein abnormalities and skin diseases and disorders
WO2011051633A3 (fr) Utilisation d'un extrait de punica granatum pour lutter contre la canitie
WO2008085875A3 (en) R-zileuton for use in conditions associated with increased 5-lipoxygenase and/or leukotriene activity (eg asthma)
WO2008120712A1 (ja) 交感神経活動亢進作用を有する医薬組成物又は飲食物
WO2011095882A8 (en) Combination composition, comprising as active ingredient l-carnitine or propionyl l-carnitine, for the prevention or treatment of chronic venous insufficiency
AU2010283453A8 (en) Combination of proanthocyanidins such as Pycnogenol or grape seeds and Centella asiatica for the treatment of cardiovascular disorders such as atherosclerosis
WO2012000962A3 (en) Use of chicoric acid and lactic bacterium in food supplement for regulating skin pigmentation
WO2007083006A3 (fr) Utilisation d'un extrait insaponifiable de pulpe vegetale dans le traitement du vieillissement cutane
WO2008126367A1 (ja) 精神安定剤および機能性食品
TW200637542A (en) Lipase inhibitor, preventing and treating agent of skin disease
WO2011118957A3 (ko) 파프리카 추출물을 함유하는 염증, 알레르기 또는 천식 질환 치료용 조성물
WO2011141113A3 (de) Kombination aus vitamin k und nikotinamid

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08765291

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009520424

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08765291

Country of ref document: EP

Kind code of ref document: A1