WO2008146731A1 - Méthode de préparation d'une solution injectable pour administration intraveineuse périphérique - Google Patents

Méthode de préparation d'une solution injectable pour administration intraveineuse périphérique Download PDF

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Publication number
WO2008146731A1
WO2008146731A1 PCT/JP2008/059524 JP2008059524W WO2008146731A1 WO 2008146731 A1 WO2008146731 A1 WO 2008146731A1 JP 2008059524 W JP2008059524 W JP 2008059524W WO 2008146731 A1 WO2008146731 A1 WO 2008146731A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
solution
intravenous administration
acid solution
peripheral intravenous
Prior art date
Application number
PCT/JP2008/059524
Other languages
English (en)
Japanese (ja)
Inventor
Mutsuo Shigeta
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to JP2009516292A priority Critical patent/JPWO2008146731A1/ja
Publication of WO2008146731A1 publication Critical patent/WO2008146731A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention a pour objet de produire une solution injectable pour administration intraveineuse périphérique qui comprend: une solution de sucre contenant de la vitamine B1 et une solution d'acide aminé, les deux solutions étant contenues séparément dans des chambres pouvant communiquer à l'intérieur d'un réceptacle multi-chambre, de telle sorte que la dégradation de l'acide aminé puisse être réduite. L'invention porte plus spécifiquement sur une méthode de préparation d'une solution injectable pour administration intraveineuse périphérique comprenant: une solution de sucre contenant, un sucre, une partie d'un électrolyte, de la vitamine B1; et une solution d'acide aminé contenant, un acide aminé, une partie d'un électrolyte, et un sulfite, les deux solutions étant contenues séparément dans des chambres pouvant communiquer à l'intérieur d'un réceptacle multi-chambre. Selon la méthode, du CO2 est dissous dans la solution d'acide aminé pour en porter l'acidité à une valeur neutre avant sa stérilisation à haute température. La solution est ensuite emballée avec un agent désoxygénant contenant du fer dans un emballage extérieur fait d'un matériau imperméable aux gaz et opaque à la lumière.
PCT/JP2008/059524 2007-05-25 2008-05-23 Méthode de préparation d'une solution injectable pour administration intraveineuse périphérique WO2008146731A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009516292A JPWO2008146731A1 (ja) 2007-05-25 2008-05-23 末梢静脈投与用輸液の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007138603 2007-05-25
JP2007-138603 2007-05-25

Publications (1)

Publication Number Publication Date
WO2008146731A1 true WO2008146731A1 (fr) 2008-12-04

Family

ID=40316831

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/059524 WO2008146731A1 (fr) 2007-05-25 2008-05-23 Méthode de préparation d'une solution injectable pour administration intraveineuse périphérique

Country Status (3)

Country Link
JP (1) JPWO2008146731A1 (fr)
TW (1) TW200914069A (fr)
WO (1) WO2008146731A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013100251A (ja) * 2011-11-09 2013-05-23 Ajinomoto Co Inc 栄養状態改善剤及び食欲改善剤

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0564653A (ja) * 1991-06-26 1993-03-19 Terumo Corp 輸液剤の包装体
JP2002065808A (ja) * 2000-08-30 2002-03-05 Nisshin Seiyaku Kk アミノ酸含有薬液入りプラスチック容器の安定な保存用包装体
JP2003055195A (ja) * 2001-08-20 2003-02-26 Terumo Corp ビタミンｂ１配合末梢静脈投与用総合輸液剤
JP2004001900A (ja) * 2003-08-05 2004-01-08 Otsuka Pharmaceut Factory Inc 中心静脈投与用輸液中のビタミン類の安定化方法
WO2004103375A1 (fr) * 2003-05-22 2004-12-02 Otsuka Pharmaceutical Factory, Inc. Preparation de transfusions pour administration intraveineuse peripherique et procede de stabilisation de la vitamine b1

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863714A (en) * 1987-02-05 1989-09-05 Cook Imaging Corporation Sterilization of compositions of limited stability
JPH0517431A (ja) * 1991-07-11 1993-01-26 Seiko Epson Corp 安定化システイン溶液
JP4000426B2 (ja) * 1996-05-08 2007-10-31 株式会社大塚製薬工場 輸液製剤
JP2003220118A (ja) * 2002-01-29 2003-08-05 Shimizu Pharmaceutical Co Ltd 薬液バッグ保存用二次包装袋
JP2006001945A (ja) * 2005-09-01 2006-01-05 Terumo Corp ビタミンｂ１配合末梢静脈投与用総合輸液剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0564653A (ja) * 1991-06-26 1993-03-19 Terumo Corp 輸液剤の包装体
JP2002065808A (ja) * 2000-08-30 2002-03-05 Nisshin Seiyaku Kk アミノ酸含有薬液入りプラスチック容器の安定な保存用包装体
JP2003055195A (ja) * 2001-08-20 2003-02-26 Terumo Corp ビタミンｂ１配合末梢静脈投与用総合輸液剤
WO2004103375A1 (fr) * 2003-05-22 2004-12-02 Otsuka Pharmaceutical Factory, Inc. Preparation de transfusions pour administration intraveineuse peripherique et procede de stabilisation de la vitamine b1
JP2004001900A (ja) * 2003-08-05 2004-01-08 Otsuka Pharmaceut Factory Inc 中心静脈投与用輸液中のビタミン類の安定化方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013100251A (ja) * 2011-11-09 2013-05-23 Ajinomoto Co Inc 栄養状態改善剤及び食欲改善剤

Also Published As

Publication number Publication date
TW200914069A (en) 2009-04-01
JPWO2008146731A1 (ja) 2010-08-19

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