WO2008126384A1 - キノロンカルボン酸誘導体の製法 - Google Patents

キノロンカルボン酸誘導体の製法 Download PDF

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Publication number
WO2008126384A1
WO2008126384A1 PCT/JP2008/000817 JP2008000817W WO2008126384A1 WO 2008126384 A1 WO2008126384 A1 WO 2008126384A1 JP 2008000817 W JP2008000817 W JP 2008000817W WO 2008126384 A1 WO2008126384 A1 WO 2008126384A1
Authority
WO
WIPO (PCT)
Prior art keywords
carboxylic acid
acid derivative
quinolone carboxylic
shown below
producing
Prior art date
Application number
PCT/JP2008/000817
Other languages
English (en)
French (fr)
Inventor
Koji Sato
Kenji Sakuratani
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020097017432A priority Critical patent/KR101419087B1/ko
Priority to BRPI0809220-6A priority patent/BRPI0809220A2/pt
Priority to ES08720683T priority patent/ES2378856T3/es
Priority to EP08720683A priority patent/EP2130827B1/en
Priority to JP2009508904A priority patent/JP5282029B2/ja
Priority to AT08720683T priority patent/ATE543809T1/de
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Priority to CA2679852A priority patent/CA2679852C/en
Priority to CN2008800111420A priority patent/CN101652357B/zh
Publication of WO2008126384A1 publication Critical patent/WO2008126384A1/ja
Priority to IL200600A priority patent/IL200600A/en
Priority to US12/569,938 priority patent/US7875722B2/en
Priority to HK10103749.6A priority patent/HK1136830A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

　本発明は、抗菌活性および安全性の高いキノロン化合物の簡便かつ高収率な製造方法に関する。 　溶媒中、塩基存在下、化合物（２）と、環状アミン（３）の塩と、ホウ素誘導体とを反応させることにより、ワンポットで目的とするキノロンカルボン酸誘導体（１）を製造する。
PCT/JP2008/000817 2007-03-30 2008-03-31 キノロンカルボン酸誘導体の製法 WO2008126384A1 (ja)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BRPI0809220-6A BRPI0809220A2 (pt) 2007-03-30 2008-03-31 Método para a produção de derivado de ácido carboxílico quinolona
ES08720683T ES2378856T3 (es) 2007-03-30 2008-03-31 Método de producción de un derivado de ácido quinolonocarboxílico
EP08720683A EP2130827B1 (en) 2007-03-30 2008-03-31 Method for producing quinolone carboxylic acid derivative
JP2009508904A JP5282029B2 (ja) 2007-03-30 2008-03-31 キノロンカルボン酸誘導体の製法
AT08720683T ATE543809T1 (de) 2007-03-30 2008-03-31 Verfahren zur herstellung eines chinolon- carboxylsäure-derivats
KR1020097017432A KR101419087B1 (ko) 2007-03-30 2008-03-31 퀴놀론카르복실산 유도체의 제법
CA2679852A CA2679852C (en) 2007-03-30 2008-03-31 Method for producing quinolone carboxylic acid derivative
CN2008800111420A CN101652357B (zh) 2007-03-30 2008-03-31 喹诺酮羧酸衍生物的制备方法
IL200600A IL200600A (en) 2007-03-30 2009-08-26 METHOD FOR PRODUCING QUINOLONIC CARBOXYLIC ACID DERIVATION
US12/569,938 US7875722B2 (en) 2007-03-30 2009-09-30 Method for producing quinolone carboxylic acid derivative
HK10103749.6A HK1136830A1 (en) 2007-03-30 2010-04-19 Method for producing quinolone carboxylic acid derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-090650 2007-03-30
JP2007090650 2007-03-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/569,938 Continuation US7875722B2 (en) 2007-03-30 2009-09-30 Method for producing quinolone carboxylic acid derivative

Publications (1)

Publication Number Publication Date
WO2008126384A1 true WO2008126384A1 (ja) 2008-10-23

Family

ID=39863544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000817 WO2008126384A1 (ja) 2007-03-30 2008-03-31 キノロンカルボン酸誘導体の製法

Country Status (13)

Country Link
US (1) US7875722B2 (ja)
EP (1) EP2130827B1 (ja)
JP (1) JP5282029B2 (ja)
KR (1) KR101419087B1 (ja)
CN (1) CN101652357B (ja)
AT (1) ATE543809T1 (ja)
BR (1) BRPI0809220A2 (ja)
CA (1) CA2679852C (ja)
ES (1) ES2378856T3 (ja)
HK (1) HK1136830A1 (ja)
IL (1) IL200600A (ja)
TW (1) TWI362386B (ja)
WO (1) WO2008126384A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114702443B (zh) * 2022-04-18 2023-09-19 重庆文理学院 喹诺酮类化合物及其中间体的制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62252772A (ja) 1986-01-21 1987-11-04 Kyorin Pharmaceut Co Ltd 選択毒性に優れた８−アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS63316757A (ja) 1987-06-18 1988-12-26 Ube Ind Ltd ３−アミノ−２−置換ベンゾイルアクリル酸誘導体
JPH0395177A (ja) 1988-05-19 1991-04-19 Chugai Pharmaceut Co Ltd 新規キノロンカルボン酸誘導体
JPH05294938A (ja) 1991-07-16 1993-11-09 Chugai Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPH07309864A (ja) * 1993-08-27 1995-11-28 Hokuriku Seiyaku Co Ltd ５−アミノ−８−メチル−７−ピロリジニルキノリン−３−カルボン酸誘導体
WO2005047260A1 (en) 2003-11-13 2005-05-26 Quimica Sintetica, S.A. Process for preparing gatifloxacin
WO2005097752A1 (en) * 2004-03-31 2005-10-20 Bayer Pharmaceuticals Corporation Quinolone carboxylic acid derivatives for treatment of hyperproliferative conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869661A (en) 1991-07-16 1999-02-09 Chugai Seiyaku Kabushiki Kaisha Method of producing a quinolonecarboxylic acid derivative

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62252772A (ja) 1986-01-21 1987-11-04 Kyorin Pharmaceut Co Ltd 選択毒性に優れた８−アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS63316757A (ja) 1987-06-18 1988-12-26 Ube Ind Ltd ３−アミノ−２−置換ベンゾイルアクリル酸誘導体
JPH0395177A (ja) 1988-05-19 1991-04-19 Chugai Pharmaceut Co Ltd 新規キノロンカルボン酸誘導体
JPH05294938A (ja) 1991-07-16 1993-11-09 Chugai Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPH07309864A (ja) * 1993-08-27 1995-11-28 Hokuriku Seiyaku Co Ltd ５−アミノ−８−メチル−７−ピロリジニルキノリン−３−カルボン酸誘導体
WO2005047260A1 (en) 2003-11-13 2005-05-26 Quimica Sintetica, S.A. Process for preparing gatifloxacin
WO2005097752A1 (en) * 2004-03-31 2005-10-20 Bayer Pharmaceuticals Corporation Quinolone carboxylic acid derivatives for treatment of hyperproliferative conditions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LIU MING-LIANG ET AL., CHINESE JOURNAL OF NEW DRUGS, vol. 13, no. 12, 2004, pages 1130
LIU MING-LIANG ET AL., CHINESE JOURNAL OF PHARMACEUTICALS, vol. 35, no. 3, 2004, pages 129
LIU MING-LIANG ET AL., CHINESE JOURNAL OF PHARMACEUTICALS, vol. 35, no. 7, 2004, pages 385
MAJID M.; HERAVI ET AL., JOURNAL OF CHEMICAL RESEARCH, 2005, pages 579

Also Published As

Publication number Publication date
CN101652357A (zh) 2010-02-17
IL200600A (en) 2014-03-31
KR20090125064A (ko) 2009-12-03
US20100063279A1 (en) 2010-03-11
TWI362386B (en) 2012-04-21
JPWO2008126384A1 (ja) 2010-07-22
CN101652357B (zh) 2013-11-20
BRPI0809220A2 (pt) 2014-09-02
CA2679852A1 (en) 2008-10-23
HK1136830A1 (en) 2010-07-09
CA2679852C (en) 2013-08-06
JP5282029B2 (ja) 2013-09-04
IL200600A0 (en) 2010-05-17
TW200846337A (en) 2008-12-01
KR101419087B1 (ko) 2014-07-11
EP2130827A4 (en) 2010-05-05
US7875722B2 (en) 2011-01-25
EP2130827A1 (en) 2009-12-09
ES2378856T3 (es) 2012-04-18
ATE543809T1 (de) 2012-02-15
EP2130827B1 (en) 2012-02-01

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