WO2008126151A1 - 質量分析データ解析方法及び装置 - Google Patents

質量分析データ解析方法及び装置 Download PDF

Info

Publication number
WO2008126151A1
WO2008126151A1 PCT/JP2007/000366 JP2007000366W WO2008126151A1 WO 2008126151 A1 WO2008126151 A1 WO 2008126151A1 JP 2007000366 W JP2007000366 W JP 2007000366W WO 2008126151 A1 WO2008126151 A1 WO 2008126151A1
Authority
WO
WIPO (PCT)
Prior art keywords
mass
peaks
mass spectrum
window
aggregating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/000366
Other languages
English (en)
French (fr)
Inventor
Shigeki Kajihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Priority to PCT/JP2007/000366 priority Critical patent/WO2008126151A1/ja
Priority to US12/594,480 priority patent/US8119982B2/en
Priority to JP2009508705A priority patent/JP4952788B2/ja
Publication of WO2008126151A1 publication Critical patent/WO2008126151A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
    • G06F2218/08—Feature extraction
    • G06F2218/10—Feature extraction by analysing the shape of a waveform, e.g. extracting parameters relating to peaks

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

　試料上の二次元領域を細かく区分した各微小領域（ピクセル）に対して得られる質量スペクトルデータを解析処理しタンパク質を同定するに際し、まず各ピクセルの質量スペクトルに現れるピークを含むように質量ウインドウを設定し（Ｓ１０）、各質量ウインドウ内に入るピークのイオン強度の積算値を計算する（Ｓ１１）。そして、質量ウインドウ毎に各ピクセルの強度積算値を集めてマッピング画像を作成し（Ｓ１２）、マッピング画像の類似性を判断して質量ウインドウをグループ分けする（Ｓ１３、Ｓ１４）。同一グループに入る質量ウインドウ内のピークは同一種類の物質に由来するとみなし、それらピークを集めて質量スペクトルを作成し（Ｓ１５）、該スペクトルに基づいてＰＭＦ法などによりタンパク質を同定する（Ｓ１６、Ｓ１７）。これにより、複数種類のタンパク質が混在している場合でも、同定精度を高めることができる。　
PCT/JP2007/000366 2007-04-04 2007-04-04 質量分析データ解析方法及び装置 Ceased WO2008126151A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/JP2007/000366 WO2008126151A1 (ja) 2007-04-04 2007-04-04 質量分析データ解析方法及び装置
US12/594,480 US8119982B2 (en) 2007-04-04 2007-04-04 Method and system for mass spectrometry data analysis
JP2009508705A JP4952788B2 (ja) 2007-04-04 2007-04-04 質量分析データ解析方法及び装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/000366 WO2008126151A1 (ja) 2007-04-04 2007-04-04 質量分析データ解析方法及び装置

Publications (1)

Publication Number Publication Date
WO2008126151A1 true WO2008126151A1 (ja) 2008-10-23

Family

ID=39863336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/000366 Ceased WO2008126151A1 (ja) 2007-04-04 2007-04-04 質量分析データ解析方法及び装置

Country Status (3)

Country Link
US (1) US8119982B2 (ja)
JP (1) JP4952788B2 (ja)
WO (1) WO2008126151A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012517588A (ja) * 2009-02-06 2012-08-02 マイクロマス・ユー・ケイ・リミテツド 質量分析方法
JP2012247198A (ja) * 2011-05-25 2012-12-13 Shimadzu Corp 質量分析データ解析方法及び解析装置
JP2013178233A (ja) * 2012-01-30 2013-09-09 Canon Inc 生体組織画像のノイズ低減処理方法及び装置
JP2014508946A (ja) * 2011-03-21 2014-04-10 イマビオテク サンプル中のターゲット分子を検出及び定量化するための方法
JP2017173103A (ja) * 2016-03-23 2017-09-28 日本電子株式会社 質量分析装置
WO2017195271A1 (ja) * 2016-05-10 2017-11-16 株式会社島津製作所 イメージング質量分析装置
WO2018037569A1 (ja) * 2016-08-26 2018-03-01 株式会社島津製作所 イメージング質量分析データ処理装置及び方法
WO2018037491A1 (ja) * 2016-08-24 2018-03-01 株式会社島津製作所 イメージング質量分析装置
CN113740408A (zh) * 2020-05-28 2021-12-03 塞莫费雪科学（不来梅）有限公司 用于确定ms扫描数据中的干扰、过滤离子并对样品进行质谱分析的方法和装置
CN114761795A (zh) * 2019-12-17 2022-07-15 豪夫迈·罗氏有限公司 用于多跃迁监测的方法和装置
CN116508060A (zh) * 2020-11-30 2023-07-28 卡尔蔡司医疗技术公司 光学相干断层扫描血管造影的质量图

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007024857B4 (de) * 2007-05-29 2017-11-02 Bruker Daltonik Gmbh Bildgebende Massenspektrometrie für kleine Moleküle in flächigen Proben
WO2010001439A1 (ja) * 2008-07-03 2010-01-07 株式会社島津製作所 質量分析装置
JP5359924B2 (ja) * 2010-02-18 2013-12-04 株式会社島津製作所 質量分析装置
JP6044385B2 (ja) * 2013-02-26 2016-12-14 株式会社島津製作所 タンデム型質量分析装置
JP2017511571A (ja) * 2014-04-02 2017-04-20 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 質量分析法によるサブミクロン元素画像解析の装置及び方法
WO2017158673A1 (ja) * 2016-03-14 2017-09-21 株式会社島津製作所 質量分析データ解析装置及び質量分析データ解析用プログラム
JP6939912B2 (ja) * 2018-02-02 2021-09-22 株式会社島津製作所 イメージング質量分析用データ処理装置
US11861826B2 (en) * 2018-05-30 2024-01-02 Shimadzu Corporation Imaging data processing device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006010658A (ja) * 2003-07-02 2006-01-12 Canon Inc 情報取得方法、情報取得装置及び検出方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808300A (en) * 1996-05-10 1998-09-15 Board Of Regents, The University Of Texas System Method and apparatus for imaging biological samples with MALDI MS
JP3658397B2 (ja) * 2002-06-28 2005-06-08 キヤノン株式会社 飛行時間型二次イオン質量分析法による素子の情報取得方法、および、情報取得装置
WO2005003715A2 (en) 2003-07-02 2005-01-13 Canon Kabushiki Kaisha Promoted ionization for secondary ion mass spectrometry
JP2006284509A (ja) 2005-04-04 2006-10-19 Shimadzu Corp 質量分析システム
WO2007116509A1 (ja) * 2006-04-07 2007-10-18 Shimadzu Corporation 質量分析装置
US7858937B2 (en) * 2006-05-30 2010-12-28 Shimadzu Corporation Mass spectrometer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006010658A (ja) * 2003-07-02 2006-01-12 Canon Inc 情報取得方法、情報取得装置及び検出方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AOYAGI S.: "Bio Device no Hiko Jikan Gata Niji Ion Shitsuryo Bunseki Imaging (Time-of-Flight Secondary Ion Mass Spectrometry Imaging of Biodevices)", J. MASS. SPECTROM. SOC. JPN., vol. 55, no. 1, 1 February 2007 (2007-02-01), pages 33 - 38, XP003022994 *
BÖRNER K. ET AL.: "Molecular imaging of lipids in cells and tissues", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 260, no. 2-3, 1 February 2007 (2007-02-01), pages 128 - 136, XP005822709 *
GARRET T.J. ET AL.: "Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. 260, no. 2-3, 1 February 2007 (2007-02-01), pages 166 - 176, XP005822713 *
TABAN I.M. ET AL.: "Imaging of Peptides in the Rat Brain Using MALDI-FTICR Mass Spectrometry", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 18, no. 1, January 2007 (2007-01-01), pages 145 - 151, XP005823248 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012517588A (ja) * 2009-02-06 2012-08-02 マイクロマス・ユー・ケイ・リミテツド 質量分析方法
JP2014508946A (ja) * 2011-03-21 2014-04-10 イマビオテク サンプル中のターゲット分子を検出及び定量化するための方法
JP2012247198A (ja) * 2011-05-25 2012-12-13 Shimadzu Corp 質量分析データ解析方法及び解析装置
US9075782B2 (en) 2011-05-25 2015-07-07 Shimadzu Corporation Mass spectrometry data analysis method and analysis device
JP2013178233A (ja) * 2012-01-30 2013-09-09 Canon Inc 生体組織画像のノイズ低減処理方法及び装置
JP2017173103A (ja) * 2016-03-23 2017-09-28 日本電子株式会社 質量分析装置
WO2017195271A1 (ja) * 2016-05-10 2017-11-16 株式会社島津製作所 イメージング質量分析装置
JPWO2017195271A1 (ja) * 2016-05-10 2018-11-08 株式会社島津製作所 イメージング質量分析装置
WO2018037491A1 (ja) * 2016-08-24 2018-03-01 株式会社島津製作所 イメージング質量分析装置
JPWO2018037491A1 (ja) * 2016-08-24 2019-01-10 株式会社島津製作所 イメージング質量分析装置
WO2018037569A1 (ja) * 2016-08-26 2018-03-01 株式会社島津製作所 イメージング質量分析データ処理装置及び方法
JPWO2018037569A1 (ja) * 2016-08-26 2019-01-10 株式会社島津製作所 イメージング質量分析データ処理装置及び方法
CN114761795A (zh) * 2019-12-17 2022-07-15 豪夫迈·罗氏有限公司 用于多跃迁监测的方法和装置
CN113740408A (zh) * 2020-05-28 2021-12-03 塞莫费雪科学（不来梅）有限公司 用于确定ms扫描数据中的干扰、过滤离子并对样品进行质谱分析的方法和装置
CN116508060A (zh) * 2020-11-30 2023-07-28 卡尔蔡司医疗技术公司 光学相干断层扫描血管造影的质量图

Also Published As

Publication number Publication date
JPWO2008126151A1 (ja) 2010-07-15
US20100116981A1 (en) 2010-05-13
JP4952788B2 (ja) 2012-06-13
US8119982B2 (en) 2012-02-21

Similar Documents

Publication Publication Date Title
WO2008126151A1 (ja) 質量分析データ解析方法及び装置
Ta et al. Twenty years of amino acid determination using capillary electrophoresis: A review
EP2579211A3 (en) Graph-based segmentation integrating visible and NIR information
WO2005010492A3 (en) Classification of disease states using mass spectrometry data
WO2004086941A3 (en) System and method for rapidly identifying pathogens, bacteria and abnormal cells
WO2004070653A3 (en) Image analysis system and method
SG10201900339QA (en) Computing device and method for detecting malicious domain names in a network traffic
EP2500841A3 (en) Video based matching and tracking
WO2005067582A3 (en) Methods and apparatus for enhanced sample identification based on combined analytical techniques
TW200700719A (en) Characteristic mass spectrum fingerprinting setting method and rapid identification method of chinese herb medicine and prescription
WO2016145331A8 (en) Methods for data-dependent mass spectrometry of mixed biomolecular analytes
US20110228970A1 (en) Mass Analysis Data Processing Method and Mass Analysis Data Processing Apparatus
WO2006113054A3 (en) Methods and apparatus for adaptive foreground background analysis
Wang et al. Rapid identification and classification of Mycobacterium spp. using whole-cell protein barcodes with matrix assisted laser desorption ionization time of flight mass spectrometry in comparison with multigene phylogenetic analysis
EP1362929A3 (en) Methods for genotyping
WO2013180818A3 (en) Deep-maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof
RU2006125736A (ru) Способ опознавания по радужной оболочке глаза и устройство для его осуществления
CN101404117A (zh) 交通标志识别方法及装置
WO2012048227A8 (en) Use of detector response curves to optimize settings for mass spectrometry
US10885673B2 (en) Method for identifying a unit using a camera
EP2975384B1 (en) Microparticle analyzing device, microparticle analyzing method, program, and microparticle analyzing system
US20140358449A1 (en) Method for identifying microorganisms by mass spectrometry
EP4375669A3 (en) Direct detection of single molecules on microparticles
EP4567416A3 (en) MASS SPECTROMETER FOR THE ANALYSIS OF FRAGMENT IONS AND CORRESPONDING METHOD
JP2015049055A (ja) 質量分析データ処理方法及び該方法を用いた質量分析装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07737023

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009508705

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 12594480

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07737023

Country of ref document: EP

Kind code of ref document: A1