WO2008122267A3 - Biochip für die fluoreszenzanalyse von einzelnen transportern - Google Patents
Biochip für die fluoreszenzanalyse von einzelnen transportern Download PDFInfo
- Publication number
- WO2008122267A3 WO2008122267A3 PCT/DE2008/000532 DE2008000532W WO2008122267A3 WO 2008122267 A3 WO2008122267 A3 WO 2008122267A3 DE 2008000532 W DE2008000532 W DE 2008000532W WO 2008122267 A3 WO2008122267 A3 WO 2008122267A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biochip
- carrying
- properties
- fluorescence analysis
- individual
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
Abstract
Die Erfindung betrifft einen Biochip (1) zur optischen Messung der Eigenschaften von einzelnen Transport-Systemen (50). Um die Eigenschaften von Transportermolekülen (50) mit hoher Messgenauigkeit und hohem Durchsatz zu messen, wird ein Biochip (1) zur optischen Messung der Eigenschaften von einzelnen Transport-Systemen (50) vorgeschlagen, der im Wesentlichen aus einem transparentem Träger (10) sowie mehreren nach oben geöffneten Vertiefungen (30) besteht, wobei der Biochip (1) derart ausgebildet ist, dass seine Öffnungen (31) durch eine Membran (40) abdeckbar sind und so geschlossene Messkammern (30) gebildet werden und der Transport von Substratmolekülen (60) über die Membran (40) in die Vertiefungen (30) nachweisbar ist.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08748708A EP2142911A2 (de) | 2007-04-04 | 2008-04-02 | Biochip für die fluoreszenzanalyse von einzelnen transportern |
US12/450,093 US20100092341A1 (en) | 2007-04-04 | 2008-04-02 | Biochip for fluorescence analysis of individual transporters |
JP2010502410A JP5370864B2 (ja) | 2007-04-04 | 2008-04-02 | 個々の輸送体の蛍光分析用バイオチップ |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007016699A DE102007016699A1 (de) | 2007-04-04 | 2007-04-04 | Biochip für die Fluoreszenzanalyse von einzelnen Transportern |
DE102007016699.2 | 2007-04-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008122267A2 WO2008122267A2 (de) | 2008-10-16 |
WO2008122267A3 true WO2008122267A3 (de) | 2008-12-11 |
Family
ID=39731117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2008/000532 WO2008122267A2 (de) | 2007-04-04 | 2008-04-02 | Biochip für die fluoreszenzanalyse von einzelnen transportern |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100092341A1 (de) |
EP (1) | EP2142911A2 (de) |
JP (1) | JP5370864B2 (de) |
DE (1) | DE102007016699A1 (de) |
WO (1) | WO2008122267A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007059166A1 (de) * | 2007-12-06 | 2009-06-10 | Synentec Gmbh | Vorrichtung zur Messung von Transportsystemen |
EP2419715A1 (de) * | 2009-04-15 | 2012-02-22 | Stefan Wennmalm | Inverse-fluoreszenz-korrelationsspektroskopie |
WO2012002515A1 (ja) * | 2010-06-30 | 2012-01-05 | 東ソー株式会社 | 粒子固定用構造体、及び、粒子解析装置 |
WO2012006995A1 (de) * | 2010-07-12 | 2012-01-19 | Nanospot Gmbh | Mikrostrukturierter messchip zur optischen messung von eigenschaften künstlicher oder biologischer membranen und verfahren zu dessen herstellung |
DE102014212695B4 (de) | 2013-07-18 | 2018-10-25 | Amo Gmbh | Verfahren zur Herstellung von Kavitäten mit nanoskaligen Blenden |
WO2015110614A1 (en) * | 2014-01-23 | 2015-07-30 | Imec Vzw | Integrated waveguide structure for fluorescence analysis |
WO2016199741A1 (ja) * | 2015-06-08 | 2016-12-15 | 国立研究開発法人科学技術振興機構 | 高密度微小チャンバーアレイおよびこれを用いた測定方法 |
CN113607714B (zh) * | 2021-10-08 | 2022-01-11 | 成都齐碳科技有限公司 | 分子膜成膜或表征器件、装置、方法以及生物芯片 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10157070A1 (de) * | 2001-11-16 | 2003-06-05 | Univ Dresden Tech | Anordnung zur Messung von durch Ionenkanäle fließende Ionenströme, sowie Verfahren zur Herstellung dieser und Messverfahren |
US20030174992A1 (en) * | 2001-09-27 | 2003-09-18 | Levene Michael J. | Zero-mode metal clad waveguides for performing spectroscopy with confined effective observation volumes |
US20040096914A1 (en) * | 2002-11-20 | 2004-05-20 | Ye Fang | Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof |
US20060060766A1 (en) * | 2004-09-17 | 2006-03-23 | Stephen Turner | Apparatus and methods for optical analysis of molecules |
US7144486B1 (en) * | 1997-04-30 | 2006-12-05 | Board Of Trustees Of The University Of Arkansas | Multilayer microcavity devices and methods |
WO2007149724A2 (en) * | 2006-06-12 | 2007-12-27 | Pacific Biosciences Of California, Inc. | Substrates for performing analytical reactions |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5111221A (en) * | 1988-05-13 | 1992-05-05 | United States Of America As Represented By The Secretary Of The Navy | Receptor-based sensor |
IL93020A (en) * | 1990-01-09 | 1995-06-29 | Yeda Res & Dev | Biosensors comprising a lipid bilayer doped with ion channels anchored to a recording electrode by bridging molecules |
US6103479A (en) * | 1996-05-30 | 2000-08-15 | Cellomics, Inc. | Miniaturized cell array methods and apparatus for cell-based screening |
DE69735601T2 (de) * | 1996-11-29 | 2007-10-18 | The Board Of Trustees Of The Leland Stanford Junior University, Stanford | Anordnungen von unabhängig voneinander ansteuerbaren, gestützten flüssigbilayer-membranen und ihre anwendungsverfahren |
US7244349B2 (en) * | 1997-12-17 | 2007-07-17 | Molecular Devices Corporation | Multiaperture sample positioning and analysis system |
US6132685A (en) * | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6323039B1 (en) * | 1999-06-22 | 2001-11-27 | Mitokor | Compositions and methods for assaying subcellular conditions and processes using energy transfer |
AU6075100A (en) * | 1999-07-07 | 2001-01-30 | Ljl Biosystems, Inc. | Light detection device |
US6977155B2 (en) * | 2000-08-10 | 2005-12-20 | Corning Incorporated | Arrays of biological membranes and methods and use thereof |
US6913697B2 (en) * | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
AU2002365079A1 (en) * | 2001-10-03 | 2003-06-30 | Osman A. Basaran | Device and bioanalytical method utilizing asymmetric biofunction alized membrane |
US20050230272A1 (en) * | 2001-10-03 | 2005-10-20 | Lee Gil U | Porous biosensing device |
US20040121377A1 (en) * | 2002-10-05 | 2004-06-24 | Chiaki Ishii | Spatially encoded and mobile arrays of tethered lipids |
US20040091397A1 (en) * | 2002-11-07 | 2004-05-13 | Corning Incorporated | Multiwell insert device that enables label free detection of cells and other objects |
US7476503B2 (en) * | 2004-09-17 | 2009-01-13 | Pacific Biosciences Of California, Inc. | Apparatus and method for performing nucleic acid analysis |
US7473533B2 (en) * | 2004-12-30 | 2009-01-06 | Corning Incorporated | Membrane arrays and methods of manufacture |
US20100019155A1 (en) * | 2005-06-23 | 2010-01-28 | Koninklijke Philips Electronics, N.V. | Luminescence sensors using sub-wavelength apertures or slits |
-
2007
- 2007-04-04 DE DE102007016699A patent/DE102007016699A1/de not_active Withdrawn
-
2008
- 2008-04-02 JP JP2010502410A patent/JP5370864B2/ja not_active Expired - Fee Related
- 2008-04-02 US US12/450,093 patent/US20100092341A1/en not_active Abandoned
- 2008-04-02 EP EP08748708A patent/EP2142911A2/de not_active Withdrawn
- 2008-04-02 WO PCT/DE2008/000532 patent/WO2008122267A2/de active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7144486B1 (en) * | 1997-04-30 | 2006-12-05 | Board Of Trustees Of The University Of Arkansas | Multilayer microcavity devices and methods |
US20030174992A1 (en) * | 2001-09-27 | 2003-09-18 | Levene Michael J. | Zero-mode metal clad waveguides for performing spectroscopy with confined effective observation volumes |
DE10157070A1 (de) * | 2001-11-16 | 2003-06-05 | Univ Dresden Tech | Anordnung zur Messung von durch Ionenkanäle fließende Ionenströme, sowie Verfahren zur Herstellung dieser und Messverfahren |
US20040096914A1 (en) * | 2002-11-20 | 2004-05-20 | Ye Fang | Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof |
US20060060766A1 (en) * | 2004-09-17 | 2006-03-23 | Stephen Turner | Apparatus and methods for optical analysis of molecules |
WO2007149724A2 (en) * | 2006-06-12 | 2007-12-27 | Pacific Biosciences Of California, Inc. | Substrates for performing analytical reactions |
Non-Patent Citations (1)
Title |
---|
LEVENE M J ET AL: "Zero-mode waveguides for single-molecule analysis at high concentrations", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, WASHINGTON, DC, vol. 299, no. 5607, 31 January 2003 (2003-01-31), pages 682 - 686, XP002341055, ISSN: 0036-8075 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008122267A2 (de) | 2008-10-16 |
DE102007016699A1 (de) | 2008-10-09 |
JP2010523987A (ja) | 2010-07-15 |
US20100092341A1 (en) | 2010-04-15 |
EP2142911A2 (de) | 2010-01-13 |
JP5370864B2 (ja) | 2013-12-18 |
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