ATE492811T1 - System zur zellbasierten reihenuntersuchun mit hoher durchlaufleistung - Google Patents
System zur zellbasierten reihenuntersuchun mit hoher durchlaufleistungInfo
- Publication number
- ATE492811T1 ATE492811T1 AT07722969T AT07722969T ATE492811T1 AT E492811 T1 ATE492811 T1 AT E492811T1 AT 07722969 T AT07722969 T AT 07722969T AT 07722969 T AT07722969 T AT 07722969T AT E492811 T1 ATE492811 T1 AT E492811T1
- Authority
- AT
- Austria
- Prior art keywords
- flow
- test solutions
- immobilisation
- array
- points
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Fluid Mechanics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Engine Equipment That Uses Special Cycles (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06004090A EP1830186A1 (de) | 2006-03-01 | 2006-03-01 | Vorrichtung für Hochdurchsatzanalyse auf Zellbasis |
PCT/EP2007/001716 WO2007098933A1 (en) | 2006-03-01 | 2007-02-28 | High-throughput cell-based screening system |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE492811T1 true ATE492811T1 (de) | 2011-01-15 |
Family
ID=36675175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07722969T ATE492811T1 (de) | 2006-03-01 | 2007-02-28 | System zur zellbasierten reihenuntersuchun mit hoher durchlaufleistung |
Country Status (5)
Country | Link |
---|---|
US (1) | US20090305901A1 (de) |
EP (2) | EP1830186A1 (de) |
AT (1) | ATE492811T1 (de) |
DE (1) | DE602007011403D1 (de) |
WO (1) | WO2007098933A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2837407T3 (es) | 2011-04-05 | 2021-06-30 | Purdue Research Foundation | Sistema microfluídico usando microaberturas para detección con alto rendimiento de entidades |
US9116145B2 (en) * | 2011-12-14 | 2015-08-25 | The George Washington University | Flexible IC/microfluidic integration and packaging |
WO2014138203A2 (en) * | 2013-03-05 | 2014-09-12 | Board Of Regents, The University Of Texas System | Microfluidic devices for the rapid and automated processing of sample populations |
CN106796166A (zh) * | 2014-06-12 | 2017-05-31 | 瓦弗根公司 | 用聚合物捕获膜进行的单细胞捕获 |
WO2018183744A1 (en) | 2017-03-29 | 2018-10-04 | The Research Foundation For The State University Of New York | Microfluidic device and methods |
CN115253845B (zh) * | 2022-07-29 | 2024-05-10 | 苏州福斯特光伏材料有限公司 | 一种用于多组分混合液的自动配料装置以及自动配料方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2496173A (en) * | 1948-06-01 | 1950-01-31 | Chad A Peebles | Adjustable appliance plug |
US4713393A (en) * | 1985-04-25 | 1987-12-15 | Merck & Co., Inc. | Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents |
DE19540304C2 (de) * | 1995-10-28 | 1998-07-30 | Braun Ag | Gerätestecker für Elektrogeräte |
CN1173776C (zh) * | 1996-06-28 | 2004-11-03 | 卡钳技术有限公司 | 在微规模流体性设备里的高通过量的筛选分析系统 |
US6664104B2 (en) * | 1999-06-25 | 2003-12-16 | Cepheid | Device incorporating a microfluidic chip for separating analyte from a sample |
GB2366087B (en) * | 2000-08-09 | 2004-05-26 | Chiu-Shan Lee | Universal electric adapter |
AU2002213423B2 (en) * | 2000-09-18 | 2007-09-06 | President And Fellows Of Harvard College | Method and apparatus for gradient generation |
TW519330U (en) * | 2001-09-04 | 2003-01-21 | Delta Electronics Inc | Rotating plug |
US7560267B2 (en) * | 2002-03-18 | 2009-07-14 | City University Of Hong Kong | Apparatus and methods for on-chip monitoring of cellular reactions |
US20040061257A1 (en) * | 2002-09-27 | 2004-04-01 | The Regents Of The University Of Michigan | Packaging technique for elastomeric microfluidic chips and microfluidic device prepared thereby |
GB0300098D0 (en) * | 2003-01-03 | 2003-02-05 | Modern Sense Ltd | Electrical adaptor |
AU2005222931A1 (en) * | 2004-03-12 | 2005-09-29 | The Regents Of The University Of California | Methods and apparatus for integrated cell handling and measurements |
US20060068608A1 (en) * | 2004-09-30 | 2006-03-30 | Mcfadden Orrin H | Rotatable outlet adaptor |
US7001196B1 (en) * | 2005-03-07 | 2006-02-21 | Cheng Uei Precision Industry Co., Ltd. | Rotatable plug with an arcing resistant mechanism |
TWM273876U (en) * | 2005-03-14 | 2005-08-21 | Cheng Uei Prec Ind Co Ltd | Rotatable plug |
TWI273752B (en) * | 2006-02-07 | 2007-02-11 | Leader Electronics Inc | Power source plug with changeable direction |
-
2006
- 2006-03-01 EP EP06004090A patent/EP1830186A1/de not_active Withdrawn
-
2007
- 2007-02-28 EP EP07722969A patent/EP1989545B1/de not_active Not-in-force
- 2007-02-28 DE DE602007011403T patent/DE602007011403D1/de active Active
- 2007-02-28 US US12/224,468 patent/US20090305901A1/en not_active Abandoned
- 2007-02-28 AT AT07722969T patent/ATE492811T1/de not_active IP Right Cessation
- 2007-02-28 WO PCT/EP2007/001716 patent/WO2007098933A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1830186A1 (de) | 2007-09-05 |
EP1989545B1 (de) | 2010-12-22 |
WO2007098933A1 (en) | 2007-09-07 |
US20090305901A1 (en) | 2009-12-10 |
DE602007011403D1 (de) | 2011-02-03 |
EP1989545A1 (de) | 2008-11-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |