ATE538214T1 - Verfahren und vorrichtung zum nachweis molekularer wechselwirkungen - Google Patents

Verfahren und vorrichtung zum nachweis molekularer wechselwirkungen

Info

Publication number
ATE538214T1
ATE538214T1 AT06819282T AT06819282T ATE538214T1 AT E538214 T1 ATE538214 T1 AT E538214T1 AT 06819282 T AT06819282 T AT 06819282T AT 06819282 T AT06819282 T AT 06819282T AT E538214 T1 ATE538214 T1 AT E538214T1
Authority
AT
Austria
Prior art keywords
microarray
molecular interactions
detecting molecular
detection
analytes
Prior art date
Application number
AT06819282T
Other languages
English (en)
Inventor
Eugen Ermantraut
Ralf Bickel
Torsten Schulz
Thomas Ullrich
Original Assignee
Clondiag Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clondiag Gmbh filed Critical Clondiag Gmbh
Application granted granted Critical
Publication of ATE538214T1 publication Critical patent/ATE538214T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/30—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
    • B01F31/31—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Length Measuring Devices With Unspecified Measuring Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
AT06819282T 2005-11-04 2006-11-06 Verfahren und vorrichtung zum nachweis molekularer wechselwirkungen ATE538214T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005052713A DE102005052713A1 (de) 2005-11-04 2005-11-04 Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
PCT/EP2006/068155 WO2007051863A2 (en) 2005-11-04 2006-11-06 Method and device for the detection of molecular interactions

Publications (1)

Publication Number Publication Date
ATE538214T1 true ATE538214T1 (de) 2012-01-15

Family

ID=37888265

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06819282T ATE538214T1 (de) 2005-11-04 2006-11-06 Verfahren und vorrichtung zum nachweis molekularer wechselwirkungen

Country Status (5)

Country Link
US (3) US8828741B2 (de)
EP (2) EP1943360B1 (de)
AT (1) ATE538214T1 (de)
DE (1) DE102005052713A1 (de)
WO (1) WO2007051863A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005052713A1 (de) 2005-11-04 2007-05-16 Clondiag Chip Tech Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
US8916348B2 (en) * 2004-05-06 2014-12-23 Clondiag Gmbh Method and device for the detection of molecular interactions
DE102006056540A1 (de) * 2006-11-28 2008-05-29 Zenteris Gmbh Vorrichtung und Verfahren zur Untersuchung von biologischen und medizinischen Proben
KR100907253B1 (ko) * 2007-10-17 2009-07-10 한국전자통신연구원 랩온어칩 및 그 구동 방법
DE102007052281A1 (de) 2007-11-02 2009-05-07 Zenteris Gmbh Einschritt-Multiplex-Immuntest
DE102008054313B4 (de) 2008-11-03 2012-12-13 Zenteris Gmbh Kartusche und Vorrichtung zur Untersuchung biologischer Proben mit temperaturgesteuerten biologischen Reaktionen
JP5744038B2 (ja) * 2009-10-21 2015-07-01 コーニンクレッカ フィリップス エヌ ヴェ 増幅反応の解析ツール
WO2011053631A1 (en) 2009-10-28 2011-05-05 Alentic Microscience Inc. Microscopy imaging
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
JP5709894B2 (ja) 2009-12-18 2015-04-30 アボット ポイント オブ ケア インコーポレイテッド 生物学的液体分析カートリッジ
CN103442809B (zh) 2010-12-03 2016-09-14 美艾利尔技术公司 通过激光照射把材料转换成光学调制状态
JP2013137267A (ja) * 2011-12-28 2013-07-11 Sony Corp マイクロチップ及びマイクロチップ型微小粒子測定装置
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
JP2016531282A (ja) * 2013-06-26 2016-10-06 アレンティック マイクロサイエンス インコーポレイテッド 顕微鏡法に関するサンプル処理の改善
KR102354648B1 (ko) * 2013-10-15 2022-01-24 바이오 몰레큘라 시스템즈 피티와이 엘티디 개선된 서모사이클러
SG10201709524QA (en) * 2013-12-26 2018-01-30 Agency Science Tech & Res Chemical sensor package for highly pressured environment
ES2822989T3 (es) 2015-04-07 2021-05-05 Cell Id Pte Ltd Calentador de corriente continua
JP2018102228A (ja) * 2016-12-27 2018-07-05 オリンパス株式会社 観察装置
CN112955258A (zh) * 2018-10-05 2021-06-11 多茨技术公司 用于过敏原检测的系统和方法
US11254979B2 (en) * 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
CN111100782A (zh) * 2019-12-31 2020-05-05 广州源起健康科技有限公司 一种实时定量基因扩增荧光检测的加热装置及其加热方法
KR20230034986A (ko) 2020-06-01 2023-03-10 샤힌 이노베이션즈 홀딩 리미티드 감염증 스크리닝 시스템
AU2021285406A1 (en) 2020-06-01 2023-01-19 Shaheen Innovations Holding Limited An infectious disease screening device
CN113759106B (zh) * 2021-11-09 2022-02-11 山东康华生物医疗科技股份有限公司 一种独立自动加液检测装置

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5013646A (en) 1989-11-03 1991-05-07 Transgenic Sciences, Inc. TMB Formulation for soluble and precipitable HRP-ELISA
GB9015793D0 (en) 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
AU5171696A (en) 1995-02-27 1996-09-18 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US5585639A (en) 1995-07-27 1996-12-17 Hewlett-Packard Company Optical scanning apparatus
CA2255774C (en) 1996-05-29 2008-03-18 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US5760950A (en) 1996-07-25 1998-06-02 Advanced Scanning, Ltd. Scanning confocal microscope
US5795748A (en) * 1996-09-26 1998-08-18 Becton Dickinson And Company DNA microwell device and method
DE19706570C1 (de) 1997-02-19 1998-02-26 Inst Physikalische Hochtech Ev Verfahren zur Herstellung von strukturierten, selbstorganisierten molekularen Monolagen einzelner molekularer Spezies, insbesondere von Substanzbibliotheken
DE19725050C2 (de) 1997-06-13 1999-06-24 Fraunhofer Ges Forschung Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung
US5910288A (en) * 1997-07-10 1999-06-08 Hewlett-Packard Company Method and apparatus for mixing a thin film of fluid
US7070921B2 (en) * 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
WO2000005336A2 (en) * 1998-07-22 2000-02-03 Ljl Biosystems, Inc. Devices and methods for sample analysis
US6197503B1 (en) 1997-11-26 2001-03-06 Ut-Battelle, Llc Integrated circuit biochip microsystem containing lens
US6271042B1 (en) 1998-08-26 2001-08-07 Alpha Innotech Corporation Biochip detection system
DE59914221D1 (de) 1998-08-28 2007-04-12 Poly An Ges Zur Herstellung Vo Verfahren zur herstellung polymerer festphasenträger
AT410718B (de) 1998-10-28 2003-07-25 Schindler Hansgeorg Dr Vorrichtung zur visualisierung von molekülen
CA2356354A1 (en) * 1998-12-23 2000-07-06 American Registry Of Pathology Apparatus and methods for efficient processing of biological samples on slides
BR0011603A (pt) 1999-05-19 2002-03-12 Advanced Array Technologies S Método para a identificação e/ou quantificação de um composto alvo obtido a partir de uma amostra biológica sobre chips
DE60022025T2 (de) * 1999-05-28 2006-06-29 Cepheid, Sunnyvale Anlage zum brechen von zellen
ATE264718T1 (de) 1999-07-02 2004-05-15 Clondiag Chip Tech Gmbh Microchip-matrix-vorrichtung zur vervielfältigung und charakterisierung von nukleinsäuren
CA2386791A1 (en) * 1999-10-08 2001-04-19 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US6569674B1 (en) * 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6589778B1 (en) * 1999-12-15 2003-07-08 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
EP1257355A2 (de) * 2000-02-22 2002-11-20 Genospectra, Inc. Verfahren und vorrichtung zur herstellung von mikroarrays
DE50108396D1 (de) 2000-07-01 2006-01-19 Clondiag Chip Tech Gmbh Verfahren zum qualitativen und/oder quantitativen nachweis von molekularen wechselwirkungen auf sonden-arrays
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US20020177157A1 (en) * 2001-05-24 2002-11-28 Yuling Luo Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity
DE10132785A1 (de) 2001-07-06 2003-01-16 Clondiag Chip Tech Gmbh Verfahren zum Nachweis von in einer Polymerase-Kettenreaktion amplifizierten Nukleinsäuremolekülen
DE10142643A1 (de) 2001-08-31 2003-04-24 Clondiag Chip Tech Gmbh Detektion von Wechselwirkungen auf Sonden-Arrays
US7332328B2 (en) * 2001-09-07 2008-02-19 Corning Incorporated Microcolumn-platform based array for high-throughput analysis
US6939032B2 (en) * 2001-10-25 2005-09-06 Erie Scientific Company Cover slip mixing apparatus
DE50210214D1 (de) * 2001-12-24 2007-07-05 Arrowhead Res Corp Verfahren zur in-vitro selektion von bindern
DE10253966B4 (de) 2002-11-19 2005-03-24 Clondiag Chip Technologies Gmbh Microarray-basiertes Verfahren zur Amplifikation und Detektion von Nukleinsäuren in einem kontinuierlichen Prozess
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20040137607A1 (en) * 2003-01-09 2004-07-15 Yokogawa Electric Corporation Biochip cartridge
DE10315074A1 (de) 2003-04-02 2004-10-14 Clondiag Chip Technologies Gmbh Vorrichtung zur Vervielfältigung und zum Nachweis von Nukleinsäuren
DE102005052752A1 (de) 2005-11-04 2007-05-10 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DE102005052713A1 (de) 2005-11-04 2007-05-16 Clondiag Chip Tech Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
US8916348B2 (en) * 2004-05-06 2014-12-23 Clondiag Gmbh Method and device for the detection of molecular interactions
DE102004022263A1 (de) * 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen

Also Published As

Publication number Publication date
US8828741B2 (en) 2014-09-09
US20090082219A1 (en) 2009-03-26
WO2007051863A3 (en) 2007-06-28
EP1943360A2 (de) 2008-07-16
EP1943360B1 (de) 2011-12-21
EP2330215A1 (de) 2011-06-08
US20150284785A1 (en) 2015-10-08
US20180135116A1 (en) 2018-05-17
US9580745B2 (en) 2017-02-28
DE102005052713A1 (de) 2007-05-16
EP2330215B1 (de) 2014-04-30
WO2007051863A2 (en) 2007-05-10

Similar Documents

Publication Publication Date Title
ATE538214T1 (de) Verfahren und vorrichtung zum nachweis molekularer wechselwirkungen
ATE477338T1 (de) Vorrichtung und verfahren zum nachweis von molekularen wechselwirkungen
ATE420211T1 (de) Vorrichtung und verfahren zum nachweis von geladenen makromolekülen
WO2006051088A3 (de) Vorrichtungen für die durchführung und analyse von mikroarray-experimenten
DE602006018477D1 (de) Dna und antikörpern sowie verwendungen davon
WO2004027379A3 (en) Methods and devices for active bioassay
WO2006076703A3 (en) Porous biosensing device
ATE504660T1 (de) Einstufige oligochromatographische vorrichtung und verfahren zu ihrer verwendung
ATE354793T1 (de) Verfahren zur erkennung eines analyten durch fluoreszenz
WO2007078635A3 (en) Method to detect small molecules binding to proteins using surface enhanced raman scattering (sers)
SE0800871L (sv) Analysförfarande och anordning
ATE506455T1 (de) Verfahren zum nachweis von mit lebensfähigkeit assoziierten molekülen
CY1114429T1 (el) Μεθοδος και διαταξη για την αναλυση αρκετων αναλυτων ταυτοχρονα με εναν εσωτερικο ελεγχο
ATE514082T1 (de) Biologischer bodendetektor
DE602007011403D1 (de) Er durchlaufleistung
DE502005004061D1 (de) Sonde zum nachweis von nukleinsäuren
DE60306328D1 (de) Verfahren zur integrierten Integritätsbewertung und Analyse von Nukleinsäuren
WO2008072192A3 (en) Biological assay substrate and method and device for producing such substrate
TW200734465A (en) Oligonucleotides, arrays thereof for detecting microorganisms, and apparatus, method and kit for detecting microorganisms
DE60226736D1 (de) Verfahren zum Anordnen einem Polymer-Molekül
WO2008140620A3 (en) Ultra sensitive biomolecule detection using double stranded dna co-loaded gold nanoparticles and co-immobilized capture molecules
DE602008004608D1 (de) Verfahren zur Erkennung von Nukleinsäuresequenzen und Substrat zur Erkennung von Nukleinsäuresequenzen
DE50207850D1 (de) Biosensor und verfahren zum erfassen von nukleinsäuren mittels mindestens zwei einheiten zum immobilisieren von nukleinsäuren
WO2002096552A3 (en) Biochip and apparatus and methods for its manufacture and use
ATE353978T1 (de) Personalisierte mikroarrays and ihre verwendung zum nachweis von zielmolekülen