WO2008105441A1 - リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤 - Google Patents

リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤 Download PDF

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Publication number
WO2008105441A1
WO2008105441A1 PCT/JP2008/053365 JP2008053365W WO2008105441A1 WO 2008105441 A1 WO2008105441 A1 WO 2008105441A1 JP 2008053365 W JP2008053365 W JP 2008053365W WO 2008105441 A1 WO2008105441 A1 WO 2008105441A1
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WO
WIPO (PCT)
Prior art keywords
phosphorus
absorption
compound
amino acid
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053365
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English (en)
French (fr)
Inventor
Tadakiyo Nakagawa
Hironobu Tsugeno
Naomi Matsutani
Masayuki Sugiki
Haruko Hirashima
Tatsuya Okuzumi
Tatsuya Kasahara
Wataru Miyanaga
Takashi Yamamoto
Masatsugu Noguchi
Kayo Matsumoto
Hideyuki Tanaka
Tomoyuki Konda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP2009501262A priority Critical patent/JPWO2008105441A1/ja
Publication of WO2008105441A1 publication Critical patent/WO2008105441A1/ja
Priority to US12/549,219 priority patent/US20100093973A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　下記一般式（Ｉ）で表される水溶性ポリアミノ酸化合物又はその塩。この化合物は、生体中のリン吸収に対する抑制効果を有し、水溶性である新規化合物である。（式中、Ｒ１～Ｒ７は同一でも異なっていてもよく、それぞれ水素原子、Ｒｘ−［Ａ］ｐ−（式中、Ａは連結基、ｐは０又は１を表し、Ｒｘはアミノカルボン酸残基等）等）を表し、Ｘ及びＹは同一でも異なっていてもよく、それぞれ−Ｎ−又は−ＣＨ−を表し、ｍ及びｎは同一でも異なっていてもよく、それぞれ２～７の整数を表し、ｍが２のとき、Ｘは−ＣＨ−を表し、ｍが３以上のとき、複数のＸ−Ｒ６は同一でも異なっていてもよいがＮ−Ｒ６が隣接することはなく、ｎが２のとき、Ｙは−ＣＨ−を表し、ｎが３以上のとき、複数のＹ−Ｒ７は同一でも異なっていてもよいがＮ−Ｒ７が隣接することはない。）
PCT/JP2008/053365 2007-02-27 2008-02-27 リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤 Ceased WO2008105441A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009501262A JPWO2008105441A1 (ja) 2007-02-27 2008-02-27 リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤
US12/549,219 US20100093973A1 (en) 2007-02-27 2009-08-27 Poly(amino acid) compound having inhibitory activity on absorption of phosphorus and phosphorus absorption inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-047633 2007-02-27
JP2007047633 2007-02-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/549,219 Continuation US20100093973A1 (en) 2007-02-27 2009-08-27 Poly(amino acid) compound having inhibitory activity on absorption of phosphorus and phosphorus absorption inhibitor

Publications (1)

Publication Number Publication Date
WO2008105441A1 true WO2008105441A1 (ja) 2008-09-04

Family

ID=39721266

Family Applications (1)

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PCT/JP2008/053365 Ceased WO2008105441A1 (ja) 2007-02-27 2008-02-27 リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤

Country Status (3)

Country Link
US (1) US20100093973A1 (ja)
JP (1) JPWO2008105441A1 (ja)
WO (1) WO2008105441A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012026988A2 (en) 2010-08-27 2012-03-01 New York University Dendrimeric peptides, pharmaceutical compositions and methods of using the same
WO2013082210A1 (en) * 2011-11-29 2013-06-06 Perosphere Inc. Anticoagulant reversal agents
ITMI20120536A1 (it) * 2012-04-02 2013-10-03 Carlo Angelo Ghisalberti Composizioni per il trattamento dell¿incontinenza urinaria da stress in soggetti femminili
US8853278B1 (en) 2013-05-22 2014-10-07 Curza Global, Llc Compositions comprising a biocidal polyamine
US9439433B2 (en) 2013-05-22 2016-09-13 Curza Global, Llc Compositions and methods comprising a biocidal polyamine
AU2018249550B2 (en) 2017-04-05 2023-11-30 Curza, Inc. Compositions and methods comprising a triaryl polyamine

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998036743A1 (en) * 1997-02-21 1998-08-27 Cypros Pharmaceutical Corporation Neuroprotective poly-guanidino compounds which block presynaptic n and p/q calcium channels
WO1999054279A1 (en) * 1998-04-20 1999-10-28 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
JP2001172244A (ja) * 1999-09-15 2001-06-26 Oridigm Corp 治療薬剤および診断薬剤としての新規なポリアミンアナログ
JP2002508349A (ja) * 1997-12-16 2002-03-19 ユニヴァーシティ・オブ・サウザンプトン 神経保護剤
JP2003504311A (ja) * 1999-06-16 2003-02-04 スミスクライン ビーチャム パブリック リミテッド カンパニー スペルミン：ペプチドをベースとする界面活性剤の化合物
JP2004509845A (ja) * 2000-05-31 2004-04-02 メディクエスト　セラピューティックス　インク 治療剤及び診断剤としての新規ポリアミン類似体
JP2005526717A (ja) * 2002-02-05 2005-09-08 ユニヴァーシティ・オブ・サウザンプトン 慢性神経変性疾患の治療のためのスペルミジン誘導体

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US5530092A (en) * 1992-01-13 1996-06-25 Dsm N.V. Dendritic macromolecule and the preparation thereof
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US7208528B1 (en) * 1997-07-15 2007-04-24 Mediquest Therapeutics, Inc. Polyamine analogues as therapeutic and diagnostic agents
US6310078B1 (en) * 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
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Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
WO1998036743A1 (en) * 1997-02-21 1998-08-27 Cypros Pharmaceutical Corporation Neuroprotective poly-guanidino compounds which block presynaptic n and p/q calcium channels
US6063819A (en) * 1997-02-21 2000-05-16 Cypros Pharmaceutical Corp. Neuroprotective poly-guanidino compounds which block presynaptic N and P/Q calcium channels
JP2002508349A (ja) * 1997-12-16 2002-03-19 ユニヴァーシティ・オブ・サウザンプトン 神経保護剤
WO1999054279A1 (en) * 1998-04-20 1999-10-28 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
JP2003504311A (ja) * 1999-06-16 2003-02-04 スミスクライン ビーチャム パブリック リミテッド カンパニー スペルミン：ペプチドをベースとする界面活性剤の化合物
JP2001172244A (ja) * 1999-09-15 2001-06-26 Oridigm Corp 治療薬剤および診断薬剤としての新規なポリアミンアナログ
JP2004509845A (ja) * 2000-05-31 2004-04-02 メディクエスト　セラピューティックス　インク 治療剤及び診断剤としての新規ポリアミン類似体
JP2005526717A (ja) * 2002-02-05 2005-09-08 ユニヴァーシティ・オブ・サウザンプトン 慢性神経変性疾患の治療のためのスペルミジン誘導体

Non-Patent Citations (3)

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Title
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DAVIS A.V. ET AL.: "A Dendritic Active Site: Catalysis of the Henry Reaction", ORGANIC LETTERS, vol. 3, no. 20, 2001, pages 3075 - 3078, XP002323376 *
PAGE P. ET AL.: "THE SYNTHESIS OF SYMMETRICAL SPERMINE CONJUGATES USING SOLID-PHASE CHEMISTRY", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 13, 1998, pages 1751 - 1756, XP004137122 *

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US20100093973A1 (en) 2010-04-15
JPWO2008105441A1 (ja) 2010-06-03

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