WO2008096831A1 - 癌の治療剤 - Google Patents

癌の治療剤 Download PDF

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Publication number
WO2008096831A1
WO2008096831A1 PCT/JP2008/052070 JP2008052070W WO2008096831A1 WO 2008096831 A1 WO2008096831 A1 WO 2008096831A1 JP 2008052070 W JP2008052070 W JP 2008052070W WO 2008096831 A1 WO2008096831 A1 WO 2008096831A1
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WO
WIPO (PCT)
Prior art keywords
cancer
antigen peptide
pertussis vaccine
vaccine
therapeutic agent
Prior art date
Application number
PCT/JP2008/052070
Other languages
English (en)
French (fr)
Inventor
Keiko Udaka
Masahide Ishibashi
Original Assignee
The Research Foundation For Microbial Diseases Of Osaka University
National University Corporation Kochi University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Research Foundation For Microbial Diseases Of Osaka University, National University Corporation Kochi University filed Critical The Research Foundation For Microbial Diseases Of Osaka University
Priority to KR1020127019378A priority Critical patent/KR101323540B1/ko
Priority to JP2008557158A priority patent/JP5239041B2/ja
Priority to US12/449,377 priority patent/US9045556B2/en
Priority to EP08710949.2A priority patent/EP2127671B1/en
Priority to KR1020097018578A priority patent/KR101183705B1/ko
Publication of WO2008096831A1 publication Critical patent/WO2008096831A1/ja
Priority to US14/700,525 priority patent/US9724403B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

　本発明は、百日咳ワクチンを主成分とする、癌抗原ペプチドワクチンおよびウイルス抗原ペプチド用アジュバントを提供する。本発明はまた、癌抗原ペプチドもしくはウイルス抗原ペプチドおよび百日咳ワクチンを含む、癌もしくはウイルス感染症の治療、並びに癌の転移や再発もしくはウイルス誘発性腫瘍の予防剤を提供する。百日咳ワクチンとしては、特に全菌体百日咳ワクチンが好適に用いられ得る。本発明の剤は、安全に複数回投与が可能である。
PCT/JP2008/052070 2007-02-07 2008-02-07 癌の治療剤 WO2008096831A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020127019378A KR101323540B1 (ko) 2007-02-07 2008-02-07 암의 치료제
JP2008557158A JP5239041B2 (ja) 2007-02-07 2008-02-07 癌の治療剤
US12/449,377 US9045556B2 (en) 2007-02-07 2008-02-07 Therapeutic agent for cancer
EP08710949.2A EP2127671B1 (en) 2007-02-07 2008-02-07 Therapeutic agent for cancer
KR1020097018578A KR101183705B1 (ko) 2007-02-07 2008-02-07 암의 치료제
US14/700,525 US9724403B2 (en) 2007-02-07 2015-04-30 Therapeutic agent for cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-028081 2007-02-07
JP2007028081 2007-02-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/449,377 A-371-Of-International US9045556B2 (en) 2007-02-07 2008-02-07 Therapeutic agent for cancer
US14/700,525 Division US9724403B2 (en) 2007-02-07 2015-04-30 Therapeutic agent for cancer

Publications (1)

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WO2008096831A1 true WO2008096831A1 (ja) 2008-08-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052070 WO2008096831A1 (ja) 2007-02-07 2008-02-07 癌の治療剤

Country Status (6)

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US (2) US9045556B2 (ja)
EP (1) EP2127671B1 (ja)
JP (1) JP5239041B2 (ja)
KR (2) KR101323540B1 (ja)
CN (2) CN101646455A (ja)
WO (1) WO2008096831A1 (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2216041A1 (en) * 2007-11-20 2010-08-11 Nec Corporation Method for induction of cytotoxic t-cell, cytotoxic t-cell inducer, and pharmaceutical composition and vaccine each comprising the inducer
WO2013089252A1 (ja) 2011-12-14 2013-06-20 国立大学法人 高知大学 ヘルパーｔ細胞誘導性ポリペプチドの改変
JP5885885B2 (ja) * 2013-03-29 2016-03-16 大日本住友製薬株式会社 Ｗｔ１抗原ペプチドコンジュゲートワクチン
JP2016518355A (ja) * 2013-04-07 2016-06-23 ザ・ブロード・インスティテュート・インコーポレイテッド 個別化された新生物ワクチンの組成物及び方法
US10426824B1 (en) 2010-05-14 2019-10-01 The General Hospital Corporation Compositions and methods of identifying tumor specific neoantigens
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
US10835585B2 (en) 2015-05-20 2020-11-17 The Broad Institute, Inc. Shared neoantigens
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
US11452768B2 (en) 2013-12-20 2022-09-27 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
US11793867B2 (en) 2017-12-18 2023-10-24 Biontech Us Inc. Neoantigens and uses thereof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765687B2 (en) 2005-10-17 2014-07-01 Sloan Kettering Institute For Cancer Research WT1 HLA class II-binding peptides and compositions and methods comprising same
CA2645766A1 (en) 2006-04-10 2007-10-25 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and methods of use thereof
EP2127671B1 (en) * 2007-02-07 2016-09-14 Nec Corporation Therapeutic agent for cancer
EP3520810A3 (en) 2012-01-13 2019-11-06 Memorial Sloan-Kettering Cancer Center Immunogenic wt1 peptides and use thereof
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
US9919037B2 (en) 2013-01-15 2018-03-20 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
EP3539562A1 (en) 2018-03-12 2019-09-18 Eberhard Karls Universität Tübingen Medizinische Fakultät Immunotherapeutic peptides
NL2031118B1 (en) * 2022-03-01 2023-09-07 Academisch Ziekenhuis Leiden T cell receptors directed against transcription factor wt1 and uses thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0580574A (ja) * 1991-09-24 1993-04-02 Oki Electric Ind Co Ltd 磁気記録媒体
WO2000006602A1 (fr) 1998-07-31 2000-02-10 Haruo Sugiyama Antigenes contre le cancer a base d'un produit du gene suppresseur de tumeur wt1
WO2000012125A1 (en) * 1998-09-01 2000-03-09 Elan Corporation, Plc Method for inducing a cell-mediated immune response and parenteral vaccine formulations therefor
WO2000026249A1 (en) 1998-11-02 2000-05-11 Imperial College Innovations Limited Immunotherapeutic methods using epitopes of wt-1 and gata-1
JP2002531520A (ja) * 1998-12-10 2002-09-24 オニバックス リミティド ガンの新規処置
WO2005105993A1 (ja) 2004-04-30 2005-11-10 Nec Corporation Ｈｌａ結合性ペプチド、その前駆体、それをコードするｄｎａ断片および組み換えベクター
WO2006030770A1 (ja) 2004-09-17 2006-03-23 Nec Corporation Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター
WO2006080142A1 (ja) 2005-01-25 2006-08-03 Nec Corporation Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター
US20070028081A1 (en) 2005-07-29 2007-02-01 Bouchier Paul H Generating an interrupt in a system having plural partitions that share a resource

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0680574A (ja) * 1991-11-05 1994-03-22 Kiichiro Ozaki 間接的癌治療剤
US6106834A (en) 1993-06-02 2000-08-22 Research Corporation Technologies, Inc. Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
EP0754193B1 (en) 1994-04-08 2000-06-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Hepatitis c virus core peptide for stimulation of cytotoxic t lymphocytes and diagnosis of hcv exposure
US6056960A (en) 1995-06-07 2000-05-02 Kaslow; Harvey R. Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof
US7655249B2 (en) * 1998-09-30 2010-02-02 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
KR20010102556A (ko) 1999-03-11 2001-11-15 추후제출 암 및 과증식성 장애의 치료 조성물 및 치료방법
WO2003050140A1 (fr) * 2001-12-10 2003-06-19 Kyogo Itoh Antigenes tumoraux
EP2127671B1 (en) * 2007-02-07 2016-09-14 Nec Corporation Therapeutic agent for cancer

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0580574A (ja) * 1991-09-24 1993-04-02 Oki Electric Ind Co Ltd 磁気記録媒体
WO2000006602A1 (fr) 1998-07-31 2000-02-10 Haruo Sugiyama Antigenes contre le cancer a base d'un produit du gene suppresseur de tumeur wt1
WO2000012125A1 (en) * 1998-09-01 2000-03-09 Elan Corporation, Plc Method for inducing a cell-mediated immune response and parenteral vaccine formulations therefor
WO2000026249A1 (en) 1998-11-02 2000-05-11 Imperial College Innovations Limited Immunotherapeutic methods using epitopes of wt-1 and gata-1
JP2002531520A (ja) * 1998-12-10 2002-09-24 オニバックス リミティド ガンの新規処置
WO2005105993A1 (ja) 2004-04-30 2005-11-10 Nec Corporation Ｈｌａ結合性ペプチド、その前駆体、それをコードするｄｎａ断片および組み換えベクター
WO2006030770A1 (ja) 2004-09-17 2006-03-23 Nec Corporation Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター
WO2006080142A1 (ja) 2005-01-25 2006-08-03 Nec Corporation Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター
US20070028081A1 (en) 2005-07-29 2007-02-01 Bouchier Paul H Generating an interrupt in a system having plural partitions that share a resource

Non-Patent Citations (32)

* Cited by examiner, † Cited by third party
Title
DI PUCCHIO, T. ET AL., CANCER RES., vol. 66, 2006, pages 4943 - 4950
DREDGE, K. ET AL., CANCER IMMUNOL. IMMUNOTHER., vol. 51, 2002, pages 521 - 531
FALLARINO, F. ET AL., J IMMUNOL, vol. 165, 2000, pages 5495 - 5501
FONG, L. ET AL., ROC. NATL. ACAD. SCI. USA, vol. 98, 2001, pages 8809 - 8814
HASKINS, K. ET AL., J. EXP. MED., vol. 157, 1983, pages 1149 - 1169
HOGQUIST, K.A. ET AL., CELL, vol. 76, 1994, pages 17 - 27
HUNT, D.F. ET AL., SCIENCE, vol. 256, 1992, pages 1817 - 1820
KANAGAWA, 0. ET AL., J. IMMUNOL., vol. 147, 1991, pages 1307 - 1314
KANAGAWA, O. ET AL., J. IMMUNOL., vol. 147, 1991, pages 1307 - 1314
MOORE, M.W. ET AL., CELL, vol. 54, 1988, pages 777 - 785
MOSOLITS, S. ET AL., ANN. ONCOL., vol. 16, 2005, pages 847 - 862
MURPHY, K.M. ET AL., SCIENCE, vol. 250, 1990, pages 1720 - 1723
NAGORSEN, D. ET AL., CLIN. CANCER RES., vol. 12, 2006, pages 3064 - 3069
NAKAJIMA, H. ET AL., CANCER IMMUNOL. IMMUNOTHER., vol. 53, 2004, pages 617 - 624
NENCIONI, A. ET AL., ANN. ONCOL., vol. 15, 2004, pages 153 - 160
OKA Y. ET AL.: "Cancer immunotherapy targeting Wilms' tumor gene WT1 product", J. IMMUNOL., vol. 164, no. 4, 2000, pages 1873 - 1880, XP001004429 *
OKA Y. ET AL.: "Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression", PROC. NATL. ACAD. SCI. U.S.A., vol. 101, no. 38, 2004, pages 13885 - 13890, XP003013276 *
OKA, Y. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 13885 - 13890
OKABE, M. ET AL., FEBS LETTERS, vol. 407, 1997, pages 313 - 319
OKABE, M. ET AL., FEBS, vol. 407, 1997, pages 313 - 319
PETERSON, A. ET AL., J. CLIN. ONCOLOGY, vol. 21, 2006, pages 2342 - 2348
ROMERO, P. ET AL., CANCER IMMUNOL. IMMUNOTHER., vol. 53, 2004, pages 249 - 255
ROSENBERG, S. A. ET AL., NAT. MED., vol. 10, 2004, pages 909 - 915
ROSENBERG, S. ET AL., NAT. MED., vol. 4, 1998, pages 321 - 327
ROSENBERG, S.A. ET AL., NAT. MED., vol. 10, 2004, pages 909 - 915
SAMBROOK ET AL.: "Molecular cloning: a laboratory manual", 1989, COLD SPRING HARBOR LAB.
See also references of EP2127671A4
SLINGLUFF, C. L. ET AL., J. CLIN. ONCOL., vol. 21, 2006, pages 4016 - 4026
SPEISER, D. E. ET AL., J. CLIN. INVEST., vol. 115, 2005, pages 739 - 746
THERESSE, P. ET AL., J NATL CANCER INST., vol. 92, 2000, pages 205 - 216
TOES, R. E. M. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 7855 - 7860
UDAKA, K. ET AL., J IMMUNOL, vol. 164, 2000, pages 1873 - 1880

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EP2127671A4 (en) 2011-06-01
US9045556B2 (en) 2015-06-02
US20100322968A1 (en) 2010-12-23
KR20090109122A (ko) 2009-10-19
EP2127671B1 (en) 2016-09-14
JPWO2008096831A1 (ja) 2010-05-27
CN105664147A (zh) 2016-06-15
KR20120098919A (ko) 2012-09-05
CN101646455A (zh) 2010-02-10
KR101183705B1 (ko) 2012-09-17
US20150265693A1 (en) 2015-09-24
EP2127671A1 (en) 2009-12-02
JP5239041B2 (ja) 2013-07-17
KR101323540B1 (ko) 2013-10-29
US9724403B2 (en) 2017-08-08

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