WO2008093677A1 - 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体 - Google Patents

血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体 Download PDF

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Publication number
WO2008093677A1
WO2008093677A1 PCT/JP2008/051312 JP2008051312W WO2008093677A1 WO 2008093677 A1 WO2008093677 A1 WO 2008093677A1 JP 2008051312 W JP2008051312 W JP 2008051312W WO 2008093677 A1 WO2008093677 A1 WO 2008093677A1
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ring
derivatives
inhibiting activity
halogeno
hydrogen
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PCT/JP2008/051312
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English (en)
French (fr)
Inventor
Takahiro Honda
Koushi Fujisawa
Hiroyuki Aono
Masakazu Ban
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Santen Pharmaceutical Co., Ltd.
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Priority to KR1020097015971A priority Critical patent/KR101475540B1/ko
Priority to US12/449,159 priority patent/US8063034B2/en
Priority to CA002676163A priority patent/CA2676163A1/en
Priority to CNA2008800034142A priority patent/CN101600712A/zh
Priority to EP08704094A priority patent/EP2128156A4/en
Publication of WO2008093677A1 publication Critical patent/WO2008093677A1/ja

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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
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  • Obesity (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

式（I）で表される化合物又はその塩。式中、環Ａはベンゼン環、チオフェン環又はピリジン環を示し；Ｒａは水素原子、ハロゲン原子、アルキル基又はアルコキシ基を示し；環Ｂはピリジン環、ピリミジン環又はキノリン環を示し；環Ｃはベンゼン環、ピリジン環、キノリン環又はイソキノリン環を示し；ＸとＹは同一又は異なって酸素原子又は硫黄原子を示し（但し、Ｘが硫黄原子かつＹが酸素原子の場合を除く）；Ｒ１は水素原子、ハロゲン原子、アミノ基、シクロアルキルアミノ基、アルキルカルボニルアミノ基、アルキルオキシカルボニルアミノ基、アルキルアミノカルボニル基又は非芳香族複素環基を示し；Ｒ２とＲ２’は同一又は異なって水素原子、ハロゲン原子、アルキル基、ハロゲノアルキル基又はハロゲノアルコキシ基を示す。 　　【化１】
PCT/JP2008/051312 2007-01-29 2008-01-29 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体 WO2008093677A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020097015971A KR101475540B1 (ko) 2007-01-29 2008-01-29 혈관 신생 저해 활성을 갖는 신규 옥사디아졸 유도체 및 티아디아졸 유도체
US12/449,159 US8063034B2 (en) 2007-01-29 2008-01-29 Oxadiazole derivatives and thiadiazole derivatives having neovascularization inhibitory activity
CA002676163A CA2676163A1 (en) 2007-01-29 2008-01-29 Novel oxadiazole derivatives and thiadiazole derivatives having neovascularization inhibitory activity
CNA2008800034142A CN101600712A (zh) 2007-01-29 2008-01-29 具有血管新生抑制活性的新型噁二唑衍生物及噻二唑衍生物
EP08704094A EP2128156A4 (en) 2007-01-29 2008-01-29 NEW OXADIAZOL DERIVATIVES AND THIADIAZONE DERIVATIVES WITH THE NEOVASCULARIZATION HEMMENDER EFFECT

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007018059 2007-01-29
JP2007-018059 2007-01-29
JP2007-083153 2007-03-28
JP2007083153 2007-03-28

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WO2008093677A1 true WO2008093677A1 (ja) 2008-08-07

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PCT/JP2008/051312 WO2008093677A1 (ja) 2007-01-29 2008-01-29 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体
PCT/JP2008/051308 WO2008093674A1 (ja) 2007-01-29 2008-01-29 キナーゼ阻害活性を有する新規チアジアゾール誘導体

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PCT/JP2008/051308 WO2008093674A1 (ja) 2007-01-29 2008-01-29 キナーゼ阻害活性を有する新規チアジアゾール誘導体

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US (1) US8063034B2 (ja)
EP (1) EP2128156A4 (ja)
JP (2) JP2008266295A (ja)
KR (1) KR101475540B1 (ja)
CN (2) CN101600712A (ja)
CA (1) CA2676163A1 (ja)
WO (2) WO2008093677A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897774B2 (en) * 2005-03-03 2011-03-01 Santen Pharmaceutical Co., Ltd. Cyclic compound having quinolylalkylthio group
JP2017071634A (ja) * 2010-03-24 2017-04-13 アミテック セラピューティック ソリューションズ，インク． キナーゼ阻害に役立つ複素環式化合物
CN108794460A (zh) * 2018-05-11 2018-11-13 贵州医科大学 一种1,2,4-噁二唑-3,4-二氢喹啉型化合物及其制备方法和用途

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TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
JP5146623B2 (ja) * 2011-03-18 2013-02-20 東洋紡株式会社 フレキシブルブーツ用ポリエステルブロック共重合体組成物
CN102584639B (zh) * 2011-12-22 2013-09-18 山东京博控股股份有限公司 对三氟甲氧基苯胺基甲酰肼的合成方法
SG10201606271RA (en) 2012-01-31 2016-09-29 Santen Pharmaceutical Co Ltd Non-aqueous liquid composition
JP6271422B2 (ja) * 2012-06-25 2018-01-31 協和発酵キリン株式会社 ４，６−ヘキサデカジエン−２，４−ジカルボン酸誘導体
CN103288817A (zh) * 2013-07-02 2013-09-11 天津理工大学 一种基于1,3,4-噻二唑和1,3,4-噁二唑的希夫碱衍生物及其制备方法和应用
CN103408540B (zh) * 2013-08-22 2016-05-18 中国药科大学 2-唑环取代噻吩类plk1抑制剂及其用途及其用途
TW201609145A (zh) 2013-12-25 2016-03-16 參天製藥股份有限公司 注射劑及形成緩釋（ｄｅｐｏｔ）之方法
EP3262041A4 (en) 2015-02-27 2018-08-01 Lycera Corporation Indazolyl thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease
EP3504204A4 (en) 2016-08-26 2020-05-27 Lycera Corporation INDAZOLYL-L, 2,4-THIADIAZOLAMINE AND RELATED COMPOUNDS FOR INHIBITING RHO-ASSOCIATED PROTEIN KINASES AND FOR TREATING DISEASES
US20200121652A1 (en) 2017-06-16 2020-04-23 The Doshisha Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent
KR102619458B1 (ko) 2017-06-16 2023-12-29 학교법인 도시샤 mTOR 인히비터를 포함하는, 눈의 증상, 장해 또는 질환을 치료 또는 예방하기 위한 의약 및 그 응용
CN108774215A (zh) * 2018-08-15 2018-11-09 翟学旭 含氮杂环类衍生物及其在视网膜新生血管疾病中的应用

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897774B2 (en) * 2005-03-03 2011-03-01 Santen Pharmaceutical Co., Ltd. Cyclic compound having quinolylalkylthio group
JP2017071634A (ja) * 2010-03-24 2017-04-13 アミテック セラピューティック ソリューションズ，インク． キナーゼ阻害に役立つ複素環式化合物
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CN108794460A (zh) * 2018-05-11 2018-11-13 贵州医科大学 一种1,2,4-噁二唑-3,4-二氢喹啉型化合物及其制备方法和用途
CN108794460B (zh) * 2018-05-11 2021-05-28 贵州医科大学 一种1,2,4-噁二唑-3,4-二氢喹啉型化合物及其制备方法和用途

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EP2128156A1 (en) 2009-12-02
WO2008093674A1 (ja) 2008-08-07
US20100016354A1 (en) 2010-01-21
JP2008266295A (ja) 2008-11-06
CN103224493A (zh) 2013-07-31
EP2128156A4 (en) 2011-05-18
JP2008266294A (ja) 2008-11-06
KR20090104087A (ko) 2009-10-05
CN101600712A (zh) 2009-12-09

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