WO2008111604A1 - 新規なベンジル(ヘテロサイクリックメチル)アミン構造を有するピリミジン化合物及びこれを含有する医薬 - Google Patents
新規なベンジル(ヘテロサイクリックメチル)アミン構造を有するピリミジン化合物及びこれを含有する医薬 Download PDFInfo
- Publication number
- WO2008111604A1 WO2008111604A1 PCT/JP2008/054459 JP2008054459W WO2008111604A1 WO 2008111604 A1 WO2008111604 A1 WO 2008111604A1 JP 2008054459 W JP2008054459 W JP 2008054459W WO 2008111604 A1 WO2008111604 A1 WO 2008111604A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl group
- lower alkyl
- hydrogen atom
- heterocyclicmethyl
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008800158234A CN101679363B (zh) | 2007-03-13 | 2008-03-12 | 具有苯甲基(杂环甲基)胺结构的嘧啶化合物及含有其的药物 |
JP2009504064A JP5204091B2 (ja) | 2007-03-13 | 2008-03-12 | 新規なベンジル(ヘテロサイクリックメチル)アミン構造を有するピリミジン化合物及びこれを含有する医薬 |
EP08721875A EP2138489B9 (en) | 2007-03-13 | 2008-03-12 | Novel pyrimidine compound having benzyl(heterocyclicmethyl)amine structure and pharmaceutical product containing the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89453407P | 2007-03-13 | 2007-03-13 | |
US60/894,534 | 2007-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008111604A1 true WO2008111604A1 (ja) | 2008-09-18 |
Family
ID=39759538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/054459 WO2008111604A1 (ja) | 2007-03-13 | 2008-03-12 | 新規なベンジル(ヘテロサイクリックメチル)アミン構造を有するピリミジン化合物及びこれを含有する医薬 |
Country Status (7)
Country | Link |
---|---|
US (2) | US7790737B2 (ja) |
EP (1) | EP2138489B9 (ja) |
JP (1) | JP5204091B2 (ja) |
KR (1) | KR20090122278A (ja) |
CN (1) | CN101679363B (ja) |
TW (1) | TW200902011A (ja) |
WO (1) | WO2008111604A1 (ja) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009051827A (ja) * | 2007-07-30 | 2009-03-12 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US20130190540A1 (en) * | 2010-07-22 | 2013-07-25 | Kowa Company, Ltd. | Method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane |
WO2014017569A1 (ja) * | 2012-07-26 | 2014-01-30 | 興和株式会社 | 血中ldlを低下させるための医薬 |
JP2014525929A (ja) * | 2011-08-18 | 2014-10-02 | ドクター レディズ ラボラトリーズ リミテッド | コレステリルエステル転送タンパク質(cetp)インヒビターとしての置換複素環式アミン化合物 |
JP2014527997A (ja) * | 2011-09-27 | 2014-10-23 | ドクター レディズ ラボラトリーズ リミテッド | アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質(cetp)インヒビターとしての5−ベンジルアミノメチル−6−アミノピラゾロ[3,4−b]ピリジン誘導体 |
JP2015054838A (ja) * | 2013-09-12 | 2015-03-23 | 興和株式会社 | 血中ldlコレステロールを低下させる医薬 |
US10653681B2 (en) | 2016-03-16 | 2020-05-19 | Recurium Ip Holdings, Llc | Analgesic compounds |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
EP1848430B1 (en) | 2004-12-31 | 2017-08-02 | Dr. Reddy's Laboratories Ltd. | Novel benzylamine derivatives as cetp inhibitors |
US7750019B2 (en) * | 2006-08-11 | 2010-07-06 | Kowa Company, Ltd. | Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same |
US7790737B2 (en) * | 2007-03-13 | 2010-09-07 | Kowa Company, Ltd. | Substituted pyrimidine compounds and their utility as CETP inhibitors |
MX2009010962A (es) * | 2007-04-13 | 2009-12-16 | Kowa Co | Compuesto pirimidina novedoso que tiene estructura de dibencilamina y medicamento que comprende el mismo. |
US20110166351A1 (en) * | 2008-09-12 | 2011-07-07 | Kowa Company, Ltd. | Method for preparing 5-[2-(methylthio)ethoxy]pyrimidine-2-amine |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997019078A1 (en) | 1995-11-21 | 1997-05-29 | Yamanouchi Pharmaceutical Co., Ltd. | Pyrido[2, 3-d] pyrimidine derivatives and medicinal compositions thereof |
JPH1149743A (ja) | 1997-02-12 | 1999-02-23 | Japan Tobacco Inc | Cetp活性阻害剤として有効な化合物 |
WO2000017166A1 (en) | 1998-09-17 | 2000-03-30 | Pfizer Products Inc. | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as cetp inhibitors |
WO2000017165A1 (en) | 1998-09-17 | 2000-03-30 | Pfizer Products Inc. | 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines as cetp inhibitors |
WO2000017164A1 (en) | 1998-09-17 | 2000-03-30 | Pfizer Products Inc. | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines as cetp inhibitors |
JP2003221376A (ja) | 2001-11-21 | 2003-08-05 | Japan Tobacco Inc | Cetp活性阻害剤 |
WO2003063868A1 (en) | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Controlled release pharmaceutical dosage forms of a cholesteryl ester transfer protein inhibitor |
WO2004020393A1 (ja) | 2002-08-30 | 2004-03-11 | Japan Tobacco Inc. | ジベンジルアミン化合物及びその医薬用途 |
WO2005095395A2 (en) | 2004-04-02 | 2005-10-13 | Tanabe Seiyaku Co., Ltd. | Tetrahydronaphthyridine derivatives as cholesteryl ester transfer protein inhibitors |
WO2006056854A1 (en) | 2004-11-23 | 2006-06-01 | Pfizer Products Inc. | Dibenzyl amine compounds and derivatives |
WO2006073973A2 (en) | 2004-12-31 | 2006-07-13 | Reddy Us Therapeutics, Inc. | Novel benzylamine derivatives as cetp inhibitors |
WO2006098394A1 (ja) | 2005-03-14 | 2006-09-21 | Japan Tobacco Inc. | 脂質吸収抑制方法および脂質吸収抑制剤 |
WO2007041494A2 (en) * | 2005-09-30 | 2007-04-12 | Merck & Co., Inc. | Cholesteryl ester transfer protein inhibitors |
WO2007073934A1 (en) * | 2005-12-29 | 2007-07-05 | Novartis Ag | Pyridinyl amine derivatives as inhibitors of cholesteryl ester transfer protein (cetp) |
WO2008018529A1 (fr) * | 2006-08-11 | 2008-02-14 | Kowa Company, Ltd. | Nouveau composé pyrimidine comportant une structure benzyl(pyridylméthyl)amine et produit pharmaceutique le comprenant |
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US82352A (en) * | 1868-09-22 | Improvement in carpet-bags | ||
US59810A (en) * | 1866-11-20 | babtlett | ||
US15758A (en) * | 1856-09-23 | Mode of adjusting- the slats of window-blinds | ||
US23729A (en) * | 1859-04-19 | Grate for furnaces | ||
US29994A (en) * | 1860-09-11 | Improvement in treadle-connections for machinery | ||
US178514A (en) * | 1876-06-13 | Improvement in hay-presses | ||
US270705A (en) * | 1883-01-16 | Hancock | ||
US54474A (en) * | 1866-05-01 | Improved rudder | ||
US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
EP1981342B1 (en) | 2005-12-28 | 2016-11-30 | Dr. Reddy's Laboratories Ltd. | Selective benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors |
PE20071025A1 (es) | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
UY30117A1 (es) | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compuesto amina trisustituido |
JP5225076B2 (ja) | 2006-04-27 | 2013-07-03 | 田辺三菱製薬株式会社 | チアゾール環を含むカルボン酸誘導体の医薬用途 |
MX2008014284A (es) | 2006-05-10 | 2008-11-18 | Novartis Ag | Derivados biciclicos como inhibidores de cetp. |
US7790737B2 (en) | 2007-03-13 | 2010-09-07 | Kowa Company, Ltd. | Substituted pyrimidine compounds and their utility as CETP inhibitors |
MX2009010962A (es) * | 2007-04-13 | 2009-12-16 | Kowa Co | Compuesto pirimidina novedoso que tiene estructura de dibencilamina y medicamento que comprende el mismo. |
-
2008
- 2008-03-11 US US12/045,982 patent/US7790737B2/en not_active Expired - Fee Related
- 2008-03-12 WO PCT/JP2008/054459 patent/WO2008111604A1/ja active Application Filing
- 2008-03-12 JP JP2009504064A patent/JP5204091B2/ja not_active Expired - Fee Related
- 2008-03-12 TW TW097108754A patent/TW200902011A/zh unknown
- 2008-03-12 EP EP08721875A patent/EP2138489B9/en not_active Not-in-force
- 2008-03-12 KR KR1020097021137A patent/KR20090122278A/ko not_active Application Discontinuation
- 2008-03-12 CN CN2008800158234A patent/CN101679363B/zh not_active Expired - Fee Related
-
2010
- 2010-06-15 US US12/815,905 patent/US8012989B2/en not_active Expired - Fee Related
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997019078A1 (en) | 1995-11-21 | 1997-05-29 | Yamanouchi Pharmaceutical Co., Ltd. | Pyrido[2, 3-d] pyrimidine derivatives and medicinal compositions thereof |
JPH1149743A (ja) | 1997-02-12 | 1999-02-23 | Japan Tobacco Inc | Cetp活性阻害剤として有効な化合物 |
WO2000017166A1 (en) | 1998-09-17 | 2000-03-30 | Pfizer Products Inc. | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as cetp inhibitors |
WO2000017165A1 (en) | 1998-09-17 | 2000-03-30 | Pfizer Products Inc. | 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines as cetp inhibitors |
WO2000017164A1 (en) | 1998-09-17 | 2000-03-30 | Pfizer Products Inc. | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines as cetp inhibitors |
JP2003221376A (ja) | 2001-11-21 | 2003-08-05 | Japan Tobacco Inc | Cetp活性阻害剤 |
WO2003063868A1 (en) | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Controlled release pharmaceutical dosage forms of a cholesteryl ester transfer protein inhibitor |
WO2004020393A1 (ja) | 2002-08-30 | 2004-03-11 | Japan Tobacco Inc. | ジベンジルアミン化合物及びその医薬用途 |
WO2005095395A2 (en) | 2004-04-02 | 2005-10-13 | Tanabe Seiyaku Co., Ltd. | Tetrahydronaphthyridine derivatives as cholesteryl ester transfer protein inhibitors |
WO2006056854A1 (en) | 2004-11-23 | 2006-06-01 | Pfizer Products Inc. | Dibenzyl amine compounds and derivatives |
WO2006073973A2 (en) | 2004-12-31 | 2006-07-13 | Reddy Us Therapeutics, Inc. | Novel benzylamine derivatives as cetp inhibitors |
WO2006098394A1 (ja) | 2005-03-14 | 2006-09-21 | Japan Tobacco Inc. | 脂質吸収抑制方法および脂質吸収抑制剤 |
WO2007041494A2 (en) * | 2005-09-30 | 2007-04-12 | Merck & Co., Inc. | Cholesteryl ester transfer protein inhibitors |
WO2007073934A1 (en) * | 2005-12-29 | 2007-07-05 | Novartis Ag | Pyridinyl amine derivatives as inhibitors of cholesteryl ester transfer protein (cetp) |
WO2008018529A1 (fr) * | 2006-08-11 | 2008-02-14 | Kowa Company, Ltd. | Nouveau composé pyrimidine comportant une structure benzyl(pyridylméthyl)amine et produit pharmaceutique le comprenant |
Non-Patent Citations (5)
Title |
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"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC. |
CIRCULATION, vol. 105, no. 18, 2002, pages 2159 - 2165 |
HIROKAWA SHOTEN: "Development of Drugs", MOLECULAR DESIGNS, vol. 7, 1990, pages 163 - 198 |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009051827A (ja) * | 2007-07-30 | 2009-03-12 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US20130190540A1 (en) * | 2010-07-22 | 2013-07-25 | Kowa Company, Ltd. | Method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane |
US9272966B2 (en) * | 2010-07-22 | 2016-03-01 | Kowa Company, Ltd. | Method for preparing optically active 1-bromo-1[3,5-bis(trifluoromethyl)phenyl]ethane |
JP2014525929A (ja) * | 2011-08-18 | 2014-10-02 | ドクター レディズ ラボラトリーズ リミテッド | コレステリルエステル転送タンパク質(cetp)インヒビターとしての置換複素環式アミン化合物 |
US9351969B2 (en) | 2011-08-18 | 2016-05-31 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (CETP) inhibitors |
JP2014527997A (ja) * | 2011-09-27 | 2014-10-23 | ドクター レディズ ラボラトリーズ リミテッド | アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質(cetp)インヒビターとしての5−ベンジルアミノメチル−6−アミノピラゾロ[3,4−b]ピリジン誘導体 |
WO2014017569A1 (ja) * | 2012-07-26 | 2014-01-30 | 興和株式会社 | 血中ldlを低下させるための医薬 |
JP2015054838A (ja) * | 2013-09-12 | 2015-03-23 | 興和株式会社 | 血中ldlコレステロールを低下させる医薬 |
US10653681B2 (en) | 2016-03-16 | 2020-05-19 | Recurium Ip Holdings, Llc | Analgesic compounds |
Also Published As
Publication number | Publication date |
---|---|
KR20090122278A (ko) | 2009-11-26 |
US8012989B2 (en) | 2011-09-06 |
EP2138489B1 (en) | 2012-07-11 |
US20090062306A1 (en) | 2009-03-05 |
CN101679363A (zh) | 2010-03-24 |
EP2138489A1 (en) | 2009-12-30 |
US7790737B2 (en) | 2010-09-07 |
TW200902011A (en) | 2009-01-16 |
EP2138489A4 (en) | 2011-07-06 |
EP2138489B9 (en) | 2012-10-24 |
JP5204091B2 (ja) | 2013-06-05 |
CN101679363B (zh) | 2013-06-05 |
JPWO2008111604A1 (ja) | 2010-06-24 |
US20100249148A1 (en) | 2010-09-30 |
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