WO2008087921A1 - 高度不飽和脂肪酸及びこれを含有する脂質の製造方法 - Google Patents

高度不飽和脂肪酸及びこれを含有する脂質の製造方法 Download PDF

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Publication number
WO2008087921A1
WO2008087921A1 PCT/JP2008/050313 JP2008050313W WO2008087921A1 WO 2008087921 A1 WO2008087921 A1 WO 2008087921A1 JP 2008050313 W JP2008050313 W JP 2008050313W WO 2008087921 A1 WO2008087921 A1 WO 2008087921A1
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Prior art keywords
fatty acid
polyunsaturated fatty
pufa
culture
lipid containing
Prior art date
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PCT/JP2008/050313
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English (en)
French (fr)
Inventor
Kenji Katano
Hiroshi Kawashima
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Suntory Holdings Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES08703177T priority Critical patent/ES2804757T3/es
Application filed by Suntory Holdings Limited filed Critical Suntory Holdings Limited
Priority to CN200880002270.9A priority patent/CN101631870B/zh
Priority to SI200832136T priority patent/SI2119791T1/sl
Priority to CA2675691A priority patent/CA2675691C/en
Priority to US12/523,087 priority patent/US8945886B2/en
Priority to DK08703177.9T priority patent/DK2119791T3/da
Priority to PL08703177T priority patent/PL2119791T3/pl
Priority to EP08703177.9A priority patent/EP2119791B1/en
Priority to LTEP08703177.9T priority patent/LT2119791T/lt
Publication of WO2008087921A1 publication Critical patent/WO2008087921A1/ja
Priority to US14/537,057 priority patent/US11525150B2/en
Priority to HRP20201009TT priority patent/HRP20201009T1/hr
Priority to CY20201100798T priority patent/CY1123310T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Husbandry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Mycology (AREA)
  • Insects & Arthropods (AREA)
  • Nutrition Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fats And Perfumes (AREA)

Abstract

　高度不飽和脂肪酸(PUFA)及びこれを含有する脂質の製造方法、PUFAを含有する微生物菌体並びにそれらの利用方法を提供する。 　アラキドン酸(ARA)及び／又はジホモ-γ-リノレン酸(DGLA)生産能を有する微生物を培養することを伴う、高度不飽和脂肪酸(PUFA)及びこれを含有する脂質の製造方法において、以下の(a)～(c)の工程：(a) 本培養開始後に、培地に有機酸を0.01～5w/v%添加する工程；(b) 本培養開始後に、培地のpHを培養有効範囲内で高めるよう制御する工程；及び(c) 本培養培地に、金属イオンの硫酸塩を0.01～0.5w/w%添加する工程；の1以上を含む、PUFA又はこれを含有する脂質の製造方法を提供する。                                                                                 
PCT/JP2008/050313 2007-01-15 2008-01-15 高度不飽和脂肪酸及びこれを含有する脂質の製造方法 WO2008087921A1 (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DK08703177.9T DK2119791T3 (da) 2007-01-15 2008-01-15 Fremgangsmåde til fremstilling af flerumættede fedtsyrer
CN200880002270.9A CN101631870B (zh) 2007-01-15 2008-01-15 多不饱和脂肪酸及含有其的脂质的制造方法
SI200832136T SI2119791T1 (sl) 2007-01-15 2008-01-15 Postopki za izdelavo večkrat nenasičene maščobne kisline in lipid, ki vsebuje večkrat nenesičeno maščobno kislino
CA2675691A CA2675691C (en) 2007-01-15 2008-01-15 Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid
US12/523,087 US8945886B2 (en) 2007-01-15 2008-01-15 Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid
ES08703177T ES2804757T3 (es) 2007-01-15 2008-01-15 Métodos para producir ácido graso poliinsaturado y lípido que contiene ácido graso poliinsaturado
PL08703177T PL2119791T3 (pl) 2007-01-15 2008-01-15 Sposoby produkcji wielonienasyconego kwasu tłuszczowego i lipidu zawierającego wielonienasycony kwas tłuszczowy
EP08703177.9A EP2119791B1 (en) 2007-01-15 2008-01-15 Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid
LTEP08703177.9T LT2119791T (lt) 2007-01-15 2008-01-15 Polineprisotintos riebalų rūgšties ir lipido, turinčio polineprisotintos riebalų rūgšties, gamybos būdas
US14/537,057 US11525150B2 (en) 2007-01-15 2014-11-10 Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid
HRP20201009TT HRP20201009T1 (hr) 2007-01-15 2020-06-26 Postupci za proizvodnju polinezasićene masne kiseline i lipida koji sadrži polinezasićenu masnu kiselinu
CY20201100798T CY1123310T1 (el) 2007-01-15 2020-08-26 Μεθοδοι παραγωγης πολυακορεστου λιπαρου οξεος και λιπιδιου που περιεχει πολυακορεστο λιπαρο οξυ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-006293 2007-01-15
JP2007006293A JP5101894B2 (ja) 2007-01-15 2007-01-15 高度不飽和脂肪酸及びこれを含有する脂質の製造方法

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/523,087 A-371-Of-International US8945886B2 (en) 2007-01-15 2008-01-15 Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid
US14/537,057 Continuation US11525150B2 (en) 2007-01-15 2014-11-10 Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid

Publications (1)

Publication Number Publication Date
WO2008087921A1 true WO2008087921A1 (ja) 2008-07-24

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Application Number Title Priority Date Filing Date
PCT/JP2008/050313 WO2008087921A1 (ja) 2007-01-15 2008-01-15 高度不飽和脂肪酸及びこれを含有する脂質の製造方法

Country Status (15)

Country Link
US (2) US8945886B2 (ja)
EP (1) EP2119791B1 (ja)
JP (1) JP5101894B2 (ja)
CN (1) CN101631870B (ja)
CA (1) CA2675691C (ja)
CY (1) CY1123310T1 (ja)
DK (1) DK2119791T3 (ja)
ES (1) ES2804757T3 (ja)
HR (1) HRP20201009T1 (ja)
HU (1) HUE050646T2 (ja)
LT (1) LT2119791T (ja)
PL (1) PL2119791T3 (ja)
PT (1) PT2119791T (ja)
SI (1) SI2119791T1 (ja)
WO (1) WO2008087921A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104087512A (zh) * 2014-05-23 2014-10-08 中国科学院青岛生物能源与过程研究所 产多不饱和脂肪酸的高山被孢霉及其应用
CN104099254A (zh) * 2014-07-11 2014-10-15 无锡超科食品有限公司 一株产多不饱和脂肪酸的菌株及其筛选方法
WO2020138480A1 (ja) * 2018-12-28 2020-07-02 日本水産株式会社 アラキドン酸含量が低減されたジホモ－γ－リノレン酸含有微生物油

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
GB0907413D0 (en) 2009-04-29 2009-06-10 Equateq Ltd Novel methods
EA031136B1 (ru) 2010-01-19 2018-11-30 ДСМ АйПи АССЕТС Б.В. Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции жирных кислот и способы их получения и применения
BR122015020126B1 (pt) 2011-07-21 2022-03-03 Dsm Ip Assets B.V Composição contendo óleo microbiano diluído
WO2013043151A1 (en) * 2011-09-19 2013-03-28 Framroze Bomi P Edible oil with a high concentration of poly-unsaturated fatty acids
MX360151B (es) * 2013-03-11 2018-10-24 Tookad Ip Sarl Metodo para producir bacterioclorofila a.
EP2826384A1 (de) 2013-07-16 2015-01-21 Evonik Industries AG Verfahren zur Trocknung von Biomasse
WO2015071766A1 (en) 2013-11-15 2015-05-21 Dignity Sciences Limited Pharmaceutically acceptable salts of polyunsaturated hydroxy fatty acids
WO2015083806A1 (ja) * 2013-12-04 2015-06-11 日本水産株式会社 微生物油、微生物油の製造方法、濃縮微生物油及び濃縮微生物油の製造方法
SG10201912145VA (en) * 2014-06-04 2020-02-27 Dignity Sciences Ltd Pharmaceutical compositions comprising dgla and use of same
US11324234B2 (en) 2014-10-02 2022-05-10 Evonik Operations Gmbh Method for raising animals
US11464244B2 (en) 2014-10-02 2022-10-11 Evonik Operations Gmbh Feedstuff of high abrasion resistance and good stability in water, containing PUFAs
DK3200606T3 (da) 2014-10-02 2021-06-21 Evonik Operations Gmbh Fremgangsmåde til fremstilling af et fodermiddel, der indeholder pufa'er, ved ekstrusion af en biomasse, der indeholder pufa'er, af typen labyrinthulomycetes
US20170295824A1 (en) 2014-10-02 2017-10-19 Evonik Degussa Gmbh Process for producing a pufa-containing biomass which has high cell stability
CN117402059A (zh) 2015-05-13 2024-01-16 Ds生物制药有限公司 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法
JP6947810B2 (ja) * 2016-07-13 2021-10-13 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 油糧微生物を含む発酵ブロスから多価不飽和脂肪酸を含む微生物油を抽出するための方法
CN107099574B (zh) * 2017-05-08 2020-05-29 山东大学 一种用于提高多不饱和脂肪酸产量的复合微生物菌剂
CN109266698B (zh) * 2018-05-17 2022-10-28 梁云 被孢霉属微生物油脂中脂肪酸组合物成分调整的方法
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0286789A (ja) * 1988-09-24 1990-03-27 Nippon Oil & Fats Co Ltd 微生物によるアラキドン酸含有油脂の製造方法
US5658767A (en) 1991-01-24 1997-08-19 Martek Corporation Arachidonic acid and methods for the production and use thereof
JP2000069987A (ja) 1998-08-28 2000-03-07 Suntory Ltd アラキドン酸含有脂質並びにジホモ−γ−リノレン酸含有脂質の製造方法
JP3354581B2 (ja) 1991-09-30 2002-12-09 サントリー株式会社 ジホモ−γ−リノレン酸及びこれを含有する脂質の製造方法
JP2006055070A (ja) 2004-08-20 2006-03-02 Yotsuba Nyugyo Kk セレブロシドの発酵生産方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US565767A (en) * 1896-08-11 William mason
JPS5091887A (ja) 1973-12-19 1975-07-22
ES2343106T3 (es) * 2000-09-28 2010-07-23 BIORIGINAL FOOD & SCIENCE CORP. Fad4, fad5, fad5-2 y fad6, miembros de la familia de desaturasas de acidos grasos y usos de los mismos.
EP1359224A1 (en) * 2002-05-01 2003-11-05 Ato B.V. A process for production of polyunsaturated fatty acids by marine microorganisms
WO2004087902A2 (de) * 2003-03-31 2004-10-14 University Of Bristol Neue pflanzliche acyltransferasen spezifisch für langkettige mehrfach ungesättigte fettsäuren
JP2006055071A (ja) 2004-08-20 2006-03-02 Yotsuba Nyugyo Kk クリヴェロマイセス・マルキシアナスによる４−ｔｒａｎｓ，８−ｔｒａｎｓ−ｓｐｈｉｎｇａｄｉｅｎｉｎｅを主要なスフィンゴイド塩基として持つセレブロシドの製造法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0286789A (ja) * 1988-09-24 1990-03-27 Nippon Oil & Fats Co Ltd 微生物によるアラキドン酸含有油脂の製造方法
US5658767A (en) 1991-01-24 1997-08-19 Martek Corporation Arachidonic acid and methods for the production and use thereof
JP3354581B2 (ja) 1991-09-30 2002-12-09 サントリー株式会社 ジホモ−γ−リノレン酸及びこれを含有する脂質の製造方法
JPH10512444A (ja) * 1995-01-03 1998-12-02 マーテック・バイオサイエンシズ・コーポレイション アラキドン酸、その製造方法およびその使用方法
JP2000069987A (ja) 1998-08-28 2000-03-07 Suntory Ltd アラキドン酸含有脂質並びにジホモ−γ−リノレン酸含有脂質の製造方法
JP2006055070A (ja) 2004-08-20 2006-03-02 Yotsuba Nyugyo Kk セレブロシドの発酵生産方法

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
ABE T. ET AL.: "Identification of mutation sites on delta5 desaturase genes from Mortierella alpine 1S-4 mutants", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 99, no. 3, 2005, pages 296 - 299, XP005665576 *
BYUNG-HAE HWANG ET AL., BIOTECHNOL LETT, vol. 27, 2005, pages 731 - 5
FUJIKAWA S. ET AL.: "Shijokin ni Yoru Arachidonic acid Gan'yu Yushi no Hakko Seisan", BIOSCIENCE & INDUSTRY, vol. 57, no. 12, 1999, pages 818 - 821, XP008112815 *
FUJIKAWA S.: "Biseibutsu Yushi no Seisan to Sono Riyo", KAGAKU TO KOGYO, vol. 74, no. 1, 2000, pages 26 - 32, XP008111128 *
H KAWASHIMA ET AL., J AM OIL CHEM SOC, vol. 77, 2000, pages 1135 - 1138
HIGASHIYAMA K. ET AL.: "Effects of mineral addition on the growth morphology of and arachidonic acid production by Mortierella alpina 1S-4", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 75, no. 12, 1998, pages 1815 - 1819, XP008054950 *
HIROSHI KAWASHIMA, FOODS FOOD INGREDIENTS J JPN, vol. 210, 2005, pages 106 - 114
HWANG B.-H. ET AL.: "High-level production of arachidonic acid by fed-batch culture of Mortierela alpine using NH40H as a nitrogen source and pH control", BIOTECHNOLOGY LETTERS, vol. 27, no. 10, 2005, pages 731 - 735, XP019230851 *
JANG H.-D. ET AL.: "Effect of culture media and conditions on polyunsaturated fatty acids production by Mortierella alpina", BIORESOURCE TECHNOLOGY, vol. 96, no. 15, 2005, pages 1633 - 1644, XP025313161 *
KAWASHIMA H. ET AL.: "Industrial production of dihomo-gamma-linolenic acid by a delta5 desaturase-defective mutant of Mortierella alpina 1S-4 fungus", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 77, no. 11, 2000, pages 1135 - 1138, XP008084822 *
KAWASHIMA H.: "Arachidonic acid to Dihomo-gamma-linolenic acid (DGLA) -Hakko Seisan to Seiri Kino-", FOODS & FOOD INGREDIENTS JOURNAL OF JAPAN, vol. 210, no. 2, 2005, pages 106 - 114, XP008112817 *
SHIGEAKI FUJIKAWA ET AL., BIOSCIENCE AND INDUSTRY, vol. 57, 1999, pages 818 - 821
TAKENO S. ET AL.: "Yushi o Tsukuru Biseibutsu no Tansaku to Ikushu -Saikin no Shinpo-", JAPANESE SCIENTIFIC MONTHLY, vol. 58, no. 10, 2005, pages 757 - 761, XP003022000 *
TOTANI N. ET AL.: "The role of morphology during growth of Mortierella alpina in arachidonic acid production", JOURNAL OF OLEO SCIENCE, vol. 51, no. 8, 2002, pages 531 - 538, XP008112814 *
YAWATA M. ET AL.: "Nyoso o Chissogen to Shita Mortierella alpina no Baiyo ni Okeru Mineral no Tenka Koka", DAI 40 KAI JAPAN OIL CHEMISTS' SOCIETY NENKAI KOEN YOSHISHU, 2001, pages 183, XP003025804 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104087512A (zh) * 2014-05-23 2014-10-08 中国科学院青岛生物能源与过程研究所 产多不饱和脂肪酸的高山被孢霉及其应用
CN104087512B (zh) * 2014-05-23 2016-06-01 中国科学院青岛生物能源与过程研究所 产多不饱和脂肪酸的高山被孢霉及其应用
CN104099254A (zh) * 2014-07-11 2014-10-15 无锡超科食品有限公司 一株产多不饱和脂肪酸的菌株及其筛选方法
WO2020138480A1 (ja) * 2018-12-28 2020-07-02 日本水産株式会社 アラキドン酸含量が低減されたジホモ－γ－リノレン酸含有微生物油

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US20150064749A1 (en) 2015-03-05
JP2008167721A (ja) 2008-07-24
CA2675691C (en) 2016-04-26
CN101631870A (zh) 2010-01-20
LT2119791T (lt) 2020-09-25
SI2119791T1 (sl) 2020-11-30
HUE050646T2 (hu) 2020-12-28
CY1123310T1 (el) 2021-12-31
JP5101894B2 (ja) 2012-12-19
CN101631870B (zh) 2015-10-21
PL2119791T3 (pl) 2020-11-16
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