HRP20201009T1 - Postupci za proizvodnju polinezasićene masne kiseline i lipida koji sadrži polinezasićenu masnu kiselinu - Google Patents
Postupci za proizvodnju polinezasićene masne kiseline i lipida koji sadrži polinezasićenu masnu kiselinu Download PDFInfo
- Publication number
- HRP20201009T1 HRP20201009T1 HRP20201009TT HRP20201009T HRP20201009T1 HR P20201009 T1 HRP20201009 T1 HR P20201009T1 HR P20201009T T HRP20201009T T HR P20201009TT HR P20201009 T HRP20201009 T HR P20201009T HR P20201009 T1 HRP20201009 T1 HR P20201009T1
- Authority
- HR
- Croatia
- Prior art keywords
- acid
- fatty acid
- polyunsaturated fatty
- culture medium
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 9
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 title 2
- 150000002632 lipids Chemical class 0.000 title 1
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 8
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims 4
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims 4
- 235000021342 arachidonic acid Nutrition 0.000 claims 4
- 229940114079 arachidonic acid Drugs 0.000 claims 4
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000907999 Mortierella alpina Species 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 229940107700 pyruvic acid Drugs 0.000 claims 1
- 238000011218 seed culture Methods 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B3/00—Refining fats or fatty oils
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Birds (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Marine Sciences & Fisheries (AREA)
- Insects & Arthropods (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fats And Perfumes (AREA)
Claims (4)
1. Postupak za proizvodnju arahidonske kiseline (ARA) i/ili dihomo-gama-linolenske kiseline (DGLA), te postupak obuhvaća kultiviranje Mortierella alpina sposobne za proizvodnju arahidonske kiseline (ARA) i/ili dihomo-gama-linolenske kiseline (DGLA), te postupak nadalje uključuje:
(a) dodavanje organske kiseline odabrane iz skupine koja sadrži jantarnu kiselinu, fumarnu kiselinu, pirogrožđanu kiselinu i jabučnu kiselinu, ili njihovu smjesu u količini od 0,01 do 5 m/v% u medij za kultiviranje tri dana ili kasnije nakon početka glavnog kultiviranja.
2. Postupak prema patentnom zahtjevu 1, naznačen time što nadalje obuhvaća
(b) povećanje pH medija za kultiviranje u rasponu od 6,9 do 7,2 tri dana ili kasnije nakon početka glavnog kultiviranja; i/ili
(c) dodavanje metalnog sulfata odabranog iz skupine koja sadrži MgSO4, CaSO4, K2SO4, FeSO4, i MnSO4, ili njihovu smjesu u količini od 0,01do 0,5 m/m% u glavni medij za kultiviranje.
3. Postupak prema patentnom zahtjevu 2, naznačen time što postupak sadrži barem korak (a) i korak (b), i pri čemu se korak (a) i korak (b) provode u različitim vremenskim točkama od dodavanja izvora ugljika medija za kultiviranje.
4. Postupak prema patentnom zahtjevu 2 ili 3, naznačen time što postupak sadrži barem korak (a) i korak (c), i pri čemu se korak (c) provodi prije dodavanja medija sjemenske kulture.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007006293A JP5101894B2 (ja) | 2007-01-15 | 2007-01-15 | 高度不飽和脂肪酸及びこれを含有する脂質の製造方法 |
| EP08703177.9A EP2119791B1 (en) | 2007-01-15 | 2008-01-15 | Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid |
| PCT/JP2008/050313 WO2008087921A1 (ja) | 2007-01-15 | 2008-01-15 | 高度不飽和脂肪酸及びこれを含有する脂質の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201009T1 true HRP20201009T1 (hr) | 2020-10-16 |
Family
ID=39635925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201009TT HRP20201009T1 (hr) | 2007-01-15 | 2020-06-26 | Postupci za proizvodnju polinezasićene masne kiseline i lipida koji sadrži polinezasićenu masnu kiselinu |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8945886B2 (hr) |
| EP (1) | EP2119791B1 (hr) |
| JP (1) | JP5101894B2 (hr) |
| CN (1) | CN101631870B (hr) |
| CA (1) | CA2675691C (hr) |
| CY (1) | CY1123310T1 (hr) |
| DK (1) | DK2119791T3 (hr) |
| ES (1) | ES2804757T3 (hr) |
| HR (1) | HRP20201009T1 (hr) |
| HU (1) | HUE050646T2 (hr) |
| LT (1) | LT2119791T (hr) |
| PL (1) | PL2119791T3 (hr) |
| PT (1) | PT2119791T (hr) |
| SI (1) | SI2119791T1 (hr) |
| WO (1) | WO2008087921A1 (hr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207363B2 (en) * | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| CA2787344C (en) | 2010-01-19 | 2018-03-20 | Dsm Ip Assets B.V. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| CN108771240A (zh) | 2011-07-21 | 2018-11-09 | 帝斯曼知识产权资产管理有限公司 | 脂肪酸组合物 |
| ES2592257T3 (es) * | 2011-09-19 | 2016-11-29 | Hofseth Biocare Asa | Aceite comestible con una concentración elevada de ácidos grasos poliinsaturados |
| US10087474B2 (en) * | 2013-03-11 | 2018-10-02 | Tookad Ip Sarl | Method for producing bacteriochlorophyll a |
| EP2826384A1 (de) | 2013-07-16 | 2015-01-21 | Evonik Industries AG | Verfahren zur Trocknung von Biomasse |
| CN109232278A (zh) | 2013-11-15 | 2019-01-18 | Ds生物制药有限公司 | 多不饱和羟基脂肪酸的药学上可接受的盐 |
| AU2014358145C1 (en) | 2013-12-04 | 2022-09-15 | Nippon Suisan Kaisha, Ltd. | Microbial oil, production method for microbial oil, concentrated microbial oil, and production method for concentrated microbial oil |
| CN104087512B (zh) * | 2014-05-23 | 2016-06-01 | 中国科学院青岛生物能源与过程研究所 | 产多不饱和脂肪酸的高山被孢霉及其应用 |
| CA2953633A1 (en) | 2014-06-04 | 2015-12-10 | Dignity Sciences Limited | Pharmaceutical compositions comprising dgla and use of same |
| CN104099254B (zh) * | 2014-07-11 | 2017-02-15 | 无锡超科食品有限公司 | 一株产多不饱和脂肪酸的菌株及其筛选方法 |
| US11324234B2 (en) | 2014-10-02 | 2022-05-10 | Evonik Operations Gmbh | Method for raising animals |
| CA2958460C (en) | 2014-10-02 | 2022-09-13 | Evonik Industries Ag | Process for producing a pufa-containing feedstuff by extruding a pufa-containing biomass |
| DK180016B1 (da) | 2014-10-02 | 2020-01-22 | Evonik Degussa Gmbh | Feedstuff of high abrasion resistance and good stability in water, containing PUFAs |
| CA2958457C (en) | 2014-10-02 | 2022-10-25 | Evonik Industries Ag | Process for producing a pufa-containing biomass which has high cell stability |
| CN109477122B (zh) * | 2016-07-13 | 2023-03-14 | 帝斯曼知识产权资产管理有限公司 | 从含有产油微生物的发酵液中提取包含多不饱和脂肪酸的微生物油的方法 |
| CN107099574B (zh) * | 2017-05-08 | 2020-05-29 | 山东大学 | 一种用于提高多不饱和脂肪酸产量的复合微生物菌剂 |
| CN109266698B (zh) * | 2018-05-17 | 2022-10-28 | 梁云 | 被孢霉属微生物油脂中脂肪酸组合物成分调整的方法 |
| EP3903883A4 (en) * | 2018-12-28 | 2022-09-28 | Nippon Suisan Kaisha, Ltd. | DIHOMO-Y-LINOLENIC ACID CONTAINING MICROBIAL OIL WITH REDUCED ARACHIDONIC ACID CONTENT |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US565767A (en) * | 1896-08-11 | William mason | ||
| JPS5091887A (hr) | 1973-12-19 | 1975-07-22 | ||
| JP2730081B2 (ja) * | 1988-09-24 | 1998-03-25 | 日本油脂株式会社 | 微生物によるアラキドン酸含有油脂の製造方法 |
| US5658767A (en) | 1991-01-24 | 1997-08-19 | Martek Corporation | Arachidonic acid and methods for the production and use thereof |
| JP3354581B2 (ja) | 1991-09-30 | 2002-12-09 | サントリー株式会社 | ジホモ−γ−リノレン酸及びこれを含有する脂質の製造方法 |
| JP2000069987A (ja) | 1998-08-28 | 2000-03-07 | Suntory Ltd | アラキドン酸含有脂質並びにジホモ−γ−リノレン酸含有脂質の製造方法 |
| AU2002218447C9 (en) * | 2000-09-28 | 2008-04-17 | Bioriginal Food & Science Corporation | Fad4, Fad5, Fad5-2, and Fad6, fatty acid desaturase family members and uses thereof |
| EP1359224A1 (en) * | 2002-05-01 | 2003-11-05 | Ato B.V. | A process for production of polyunsaturated fatty acids by marine microorganisms |
| AU2004225838B2 (en) * | 2003-03-31 | 2009-11-05 | University Of Bristol | Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids |
| JP2006055070A (ja) | 2004-08-20 | 2006-03-02 | Yotsuba Nyugyo Kk | セレブロシドの発酵生産方法 |
| JP2006055071A (ja) | 2004-08-20 | 2006-03-02 | Yotsuba Nyugyo Kk | クリヴェロマイセス・マルキシアナスによる４−ｔｒａｎｓ，８−ｔｒａｎｓ−ｓｐｈｉｎｇａｄｉｅｎｉｎｅを主要なスフィンゴイド塩基として持つセレブロシドの製造法 |
-
2007
- 2007-01-15 JP JP2007006293A patent/JP5101894B2/ja active Active
-
2008
- 2008-01-15 SI SI200832136T patent/SI2119791T1/sl unknown
- 2008-01-15 CA CA2675691A patent/CA2675691C/en active Active
- 2008-01-15 DK DK08703177.9T patent/DK2119791T3/da active
- 2008-01-15 US US12/523,087 patent/US8945886B2/en active Active
- 2008-01-15 LT LTEP08703177.9T patent/LT2119791T/lt unknown
- 2008-01-15 EP EP08703177.9A patent/EP2119791B1/en active Active
- 2008-01-15 PT PT87031779T patent/PT2119791T/pt unknown
- 2008-01-15 PL PL08703177T patent/PL2119791T3/pl unknown
- 2008-01-15 ES ES08703177T patent/ES2804757T3/es active Active
- 2008-01-15 HU HUE08703177A patent/HUE050646T2/hu unknown
- 2008-01-15 WO PCT/JP2008/050313 patent/WO2008087921A1/ja active Application Filing
- 2008-01-15 CN CN200880002270.9A patent/CN101631870B/zh active Active
-
2014
- 2014-11-10 US US14/537,057 patent/US11525150B2/en active Active
-
2020
- 2020-06-26 HR HRP20201009TT patent/HRP20201009T1/hr unknown
- 2020-08-26 CY CY20201100798T patent/CY1123310T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11525150B2 (en) | 2022-12-13 |
| CY1123310T1 (el) | 2021-12-31 |
| US20100167359A1 (en) | 2010-07-01 |
| CA2675691C (en) | 2016-04-26 |
| JP5101894B2 (ja) | 2012-12-19 |
| EP2119791A1 (en) | 2009-11-18 |
| CA2675691A1 (en) | 2008-07-24 |
| SI2119791T1 (sl) | 2020-11-30 |
| WO2008087921A1 (ja) | 2008-07-24 |
| PT2119791T (pt) | 2020-08-28 |
| ES2804757T3 (es) | 2021-02-09 |
| EP2119791A4 (en) | 2013-05-29 |
| JP2008167721A (ja) | 2008-07-24 |
| DK2119791T3 (da) | 2020-08-03 |
| US20150064749A1 (en) | 2015-03-05 |
| CN101631870B (zh) | 2015-10-21 |
| LT2119791T (lt) | 2020-09-25 |
| PL2119791T3 (pl) | 2020-11-16 |
| HUE050646T2 (hu) | 2020-12-28 |
| US8945886B2 (en) | 2015-02-03 |
| CN101631870A (zh) | 2010-01-20 |
| EP2119791B1 (en) | 2020-06-17 |
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