AR083443A1 - Una composicion que comprende arn bacteriano y paredes celulares bacterianas, metodo para elaborar dicha composicion y sus usos - Google Patents

Una composicion que comprende arn bacteriano y paredes celulares bacterianas, metodo para elaborar dicha composicion y sus usos

Info

Publication number
AR083443A1
AR083443A1 ARP110103806A ARP110103806A AR083443A1 AR 083443 A1 AR083443 A1 AR 083443A1 AR P110103806 A ARP110103806 A AR P110103806A AR P110103806 A ARP110103806 A AR P110103806A AR 083443 A1 AR083443 A1 AR 083443A1
Authority
AR
Argentina
Prior art keywords
composition
bacterial
mycobacterial
following
compositions
Prior art date
Application number
ARP110103806A
Other languages
English (en)
Inventor
Danbing Ke
Zdenek R Holan
Nigel C Phillips
Mario C Filion
Mohamed Elrafih
Original Assignee
Bioniche Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioniche Life Sciences Inc filed Critical Bioniche Life Sciences Inc
Publication of AR083443A1 publication Critical patent/AR083443A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C12N1/066—Lysis of microorganisms by physical methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer

Abstract

Composiciones bacterianas y micobacterianas que contienen ARN y paredes bacterianas, y métodos para elaborar y utilizar estas composiciones. Estas composiciones tienen actividad anticancerosa e inmunoestimuladora.Reivindicación 1: Una composición caracterizada porque comprende lo siguiente: ARN micobacteriano; y, paredes micobacterianas, en las cuales la composición no contiene fenol ni pronase [micolisina]. Reivindicación 2: La composición de acuerdo con la reivindicación 1, caracterizada porque comprende, además, células micobacterianas intactas. Reivindicación 18: Un medio sintético para el cultivo de micobacterias caracterizado porque comprende lo siguiente: medio de cultivo Middlebrook 7H9 en polvo; glucosa; glicerol; hierro adicional; carbono adicional; nitrógeno adicional; y agua. Reivindicación 20: Un medio sintético para el cultivo de micobacterias caracterizada porque comprende lo siguiente: citrato de amonio; ácido L-glutámico; piridoxina; biotina; fosfato disódico; fosfato monopotásico; citrato de amonio férrico; sulfato de magnesio; cloruro de calcio; sulfato de zinc; ácido oleico; glicerol; glucosa; y agua.
ARP110103806A 2010-10-13 2011-10-13 Una composicion que comprende arn bacteriano y paredes celulares bacterianas, metodo para elaborar dicha composicion y sus usos AR083443A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39249810P 2010-10-13 2010-10-13
US39358910P 2010-10-15 2010-10-15

Publications (1)

Publication Number Publication Date
AR083443A1 true AR083443A1 (es) 2013-02-27

Family

ID=45937957

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110103806A AR083443A1 (es) 2010-10-13 2011-10-13 Una composicion que comprende arn bacteriano y paredes celulares bacterianas, metodo para elaborar dicha composicion y sus usos

Country Status (19)

Country Link
US (5) US9044422B2 (es)
EP (1) EP2571979B1 (es)
JP (1) JP6163425B2 (es)
KR (2) KR20140031168A (es)
CN (2) CN103354833B (es)
AR (1) AR083443A1 (es)
AU (1) AU2011315093B2 (es)
BR (1) BR112013008727A2 (es)
CA (1) CA2799442C (es)
DK (1) DK2571979T3 (es)
ES (1) ES2829416T3 (es)
HU (1) HUE052413T2 (es)
IL (1) IL225718A (es)
MX (1) MX340143B (es)
RU (1) RU2013121577A (es)
SG (1) SG189365A1 (es)
UY (1) UY33668A (es)
WO (1) WO2012049654A1 (es)
ZA (1) ZA201302722B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX340143B (es) 2010-10-13 2016-06-28 Telesta Therapeutics Ip Inc Composiciones de pared de célula de ácido ribonucléico bacterial y métodos para hacerlas y usarlas.
US10434171B2 (en) 2016-12-23 2019-10-08 United States of America as Represented by Secretary of Agriculture Microfluidized Mycobacterium avium fragments as an adjuvant and carrier for mucosal vaccine delivery
US20200237904A1 (en) * 2017-01-26 2020-07-30 Immune Therapeutics Inc. Methods and Compositions Useful for Treating Cancer
WO2019088590A2 (ko) 2017-11-06 2019-05-09 서울대학교 산학협력단 마이코박테리움 파라고르도네의 항암 면역치료법 용도
CN111000978B (zh) * 2019-11-22 2023-03-10 中山大学附属第五医院 Tlt-2在制备治疗结核病药物中的应用
CN112156719B (zh) * 2020-08-26 2022-02-22 夏文杰 一种两性糖脂生物表面活性剂及其制备方法
CN113341023B (zh) * 2021-06-30 2022-12-23 大连医科大学附属第一医院 一种基于液质联用的血清二氨基庚二酸的检测试剂盒及检测方法与应用
CN114958831A (zh) * 2022-06-30 2022-08-30 上海纳米技术及应用国家工程研究中心有限公司 一种难裂解细菌基因组dna提取方法

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JPS5328989B2 (es) * 1974-05-27 1978-08-17
US4744984A (en) * 1985-10-08 1988-05-17 Vetrepharm Research, Inc. Antiviral immunotherapeutic agent and preparation thereof
DK0681479T3 (da) * 1993-01-29 1999-11-08 Vetrepharm Inc Immunterapeutisk præparat
DE4422859C2 (de) * 1994-06-30 2000-10-05 Laves Arzneimittel Gmbh Wäßrige Zellextrakte aus Mykobacterien
AUPO359396A0 (en) * 1996-11-13 1996-12-05 Amrad Operations Pty. Limited A method of treatment and pharmaceutical compositions useful for same
US6139844A (en) 1997-04-02 2000-10-31 Bioniche, Inc. Method for treating or eliminating a parasitic disease
EP1003525B1 (en) * 1997-08-05 2002-11-20 Bioniche Life Sciences Inc. Composition and method for regulating cell proliferation and cell death
WO1999042113A1 (en) * 1998-02-18 1999-08-26 Bioniche Life Sciences Inc. Composition and method for the treatment of bladder cancer
CA2353905C (en) * 1998-12-04 2010-06-22 Nigel C. Phillips Chemotherapeutic composition and method
DK1135164T3 (da) 1998-12-04 2004-12-20 Bioniche Life Sciences Inc Sammensætning til behandling af inflammation
US6809081B1 (en) 1998-12-04 2004-10-26 Bioniche Life Sciences, Inc. Chemotherapeutic composition and method
US6794368B1 (en) 1999-04-01 2004-09-21 Bioniche Life Sciences Inc. Composition and method for inducing apoptosis in prostate cancer cells
US6890541B1 (en) * 1999-07-23 2005-05-10 Bioniche Life Sciences, Inc. Method for enhancing production performance in an animal
JP4215429B2 (ja) 1999-12-28 2009-01-28 バイオニケ ライフ サイエンシーズ インコーポレイテッド 癌治療におけるヒアルロン酸
UA79952C2 (en) * 2001-12-10 2007-08-10 Kabulesh Mafatlal Khamar MYCOBACTERIUM w APPLICATIONS FOR CANCER TREATMENT
MX340143B (es) 2010-10-13 2016-06-28 Telesta Therapeutics Ip Inc Composiciones de pared de célula de ácido ribonucléico bacterial y métodos para hacerlas y usarlas.

Also Published As

Publication number Publication date
CN103354833A (zh) 2013-10-16
ZA201302722B (en) 2014-06-25
CA2799442C (en) 2015-07-14
KR20160083968A (ko) 2016-07-12
EP2571979A4 (en) 2013-12-11
SG189365A1 (en) 2013-05-31
CN103354833B (zh) 2016-11-16
US9220765B2 (en) 2015-12-29
US9180176B2 (en) 2015-11-10
MX340143B (es) 2016-06-28
BR112013008727A2 (pt) 2016-06-28
US20160151475A1 (en) 2016-06-02
JP6163425B2 (ja) 2017-07-12
US20130142828A1 (en) 2013-06-06
KR20140031168A (ko) 2014-03-12
MX2013004044A (es) 2013-08-15
US20140322372A1 (en) 2014-10-30
AU2011315093B2 (en) 2013-10-17
WO2012049654A1 (en) 2012-04-19
US9044422B2 (en) 2015-06-02
AU2011315093A8 (en) 2013-01-17
US20140170189A1 (en) 2014-06-19
DK2571979T3 (da) 2020-09-28
CN105943559A (zh) 2016-09-21
US20150224183A1 (en) 2015-08-13
IL225718A (en) 2016-04-21
CA2799442A1 (en) 2012-04-19
AU2011315093A1 (en) 2013-01-10
US9180177B2 (en) 2015-11-10
JP2014502256A (ja) 2014-01-30
HUE052413T2 (hu) 2021-04-28
RU2013121577A (ru) 2014-11-20
EP2571979A1 (en) 2013-03-27
UY33668A (es) 2012-08-31
EP2571979B1 (en) 2020-06-24
IL225718A0 (en) 2013-06-27
ES2829416T3 (es) 2021-05-31

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