WO2008062648A1 - Cartouche de biocapteur et appareil de biocapteur - Google Patents

Cartouche de biocapteur et appareil de biocapteur Download PDF

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Publication number
WO2008062648A1
WO2008062648A1 PCT/JP2007/071332 JP2007071332W WO2008062648A1 WO 2008062648 A1 WO2008062648 A1 WO 2008062648A1 JP 2007071332 W JP2007071332 W JP 2007071332W WO 2008062648 A1 WO2008062648 A1 WO 2008062648A1
Authority
WO
WIPO (PCT)
Prior art keywords
biosensor
puncture
port
chip
tip
Prior art date
Application number
PCT/JP2007/071332
Other languages
English (en)
Japanese (ja)
Inventor
Tsuyoshi Fujimura
Hideaki Nakamura
Tomoko Ishikawa
Masao Gotoh
Isao Karube
Shingo Kaimori
Takahiko Kitamura
Hiroto Nakajima
Hiroshi Hayami
Toshifumi Hosoya
Original Assignee
National Institute Of Advanced Industrial Science And Technology
Sumitomo Electric Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute Of Advanced Industrial Science And Technology, Sumitomo Electric Industries, Ltd. filed Critical National Institute Of Advanced Industrial Science And Technology
Publication of WO2008062648A1 publication Critical patent/WO2008062648A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150541—Breakable protectors, e.g. caps, shields or sleeves, i.e. protectors separated destructively, e.g. by breaking a connecting area
    • A61B5/150549—Protectors removed by rotational movement, e.g. torsion or screwing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/15058—Joining techniques used for protective means
    • A61B5/150618—Integrally moulded protectors, e.g. protectors simultaneously moulded together with a further component, e.g. a hub, of the piercing element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150717—Procedure for removing protection means at the time of piercing manually removed

Definitions

  • the present invention relates to a biosensor cartridge, for example, a biosensor cartridge and a biosensor device that measure and analyze a chemical substance using a reagent contained in a hollow reaction part of a chip.
  • biosensor chips that detect the concentration of glucose in blood are known (see, for example, Patent Document 1).
  • FIG. 6 is an exploded perspective view showing the glucose sensor described in Patent Document 1.
  • a glucose sensor 100 as a biosensor has a counter electrode 101 and a working electrode 102.
  • the counter electrode 101 has a hollow needle shape cut in half in the length direction, and a distal end portion 103 thereof is obliquely cut into an injection needle shape so as to be easily punctured.
  • the cut surfaces that have been cut are generally coated with insulating layers 104 and 104 'that also serve as adhesive layers, such as epoxy resin adhesives, silicone adhesives, or glass.
  • the working electrode 102 is attached via '.
  • the working electrode 102 is a flat plate member to which glucose oxidase (GOD) is immobilized.
  • the so-called immobilized GOD105 surface on which the GOD is immobilized is adhered to the counter electrode 101 with the surface side facing inward! / .
  • FIG. 7A is a perspective view of the sensor described in Patent Document 2
  • FIG. 7B is an exploded perspective view of the sensor.
  • the lancet-integrated sensor 110 has a chip body 111, a lancet 113, and a protective cannula 115, and is laid out.
  • the chip body 111 (the board 111a and the substrate 111b can be opened and closed, and the inner space 112 is formed on the inner surface of the cover 111a. Is formed.
  • the internal space 112 has a shape that can accommodate the lancet 113 in a movable manner.
  • the needle 114 provided at the tip of the lancet 113 is formed at the front end of the internal space 112 of the tip body 111 as the lancet 113 moves! It has become.
  • the shape of the internal space 11 la is curved so that the width thereof is slightly narrower than that of the lancet 113 at the end where the protrusion 113a is located, and the lancet 113 is attached to the chip body 111 by the mutual pressing force and frictional force. Being locked up! /
  • the protective cover 115 has a tube portion 115 a into which the needle 114 is fitted, and the tube portion 115 a can be accommodated inside the chip body 111 as the needle 114 moves.
  • the protective cover 115 is put on the needle 114 to protect the needle 114 and to prevent accidental injury to the user.
  • the substrate 11 lb is provided with a pair of electrode terminals 116 so that it can be electrically connected to a biosensor device (not shown).
  • the needle 114 is housed inside the chip body 111, and the opening 112a provided at the front end of the chip body 111 is brought close to the puncture port to collect the spilled blood. .
  • Patent Document 1 Japanese Patent Laid-Open No. 2-120655
  • Patent Document 2 Pamphlet of International Publication No. 02/056769
  • the lancet-integrated sensor 110 described in Patent Document 2 has a complicated force S and a structure that absorbs blood flowing out from the puncture port from the opening 112a.
  • the present invention has been made in view of the above-described problems, and an object of the present invention is to reduce the burden on the user by reducing the amount of sample collected for measurement and puncture the sample collection port. It is an object of the present invention to provide a biosensor cartridge and a biosensor device capable of performing a more accurate measurement as much as possible by easily collecting and measuring a sample of a puncture mouth without requiring an operation to bring the mouth close.
  • a biosensor force cartridge includes a biosensor chip having a sample collection port for collecting a sample at a tip portion, and the biosensor chip.
  • a biosensor cartridge having a puncture device fixed to the puncture device, wherein the sample collection port is opened in a direction intersecting the axis of the puncture device.
  • the sample collection port can be made closer to the puncture port formed by the tip of the puncture device than before, a small amount of the sample collection port can be obtained. This sample can be easily collected through the sampling port, and a reliable inspection can be performed.
  • the biosensor cartridge that is the second feature of the present invention is characterized in that, in the first feature of the present invention, the sampling port is provided at a corner of the tip of the biosensor chip. It is what.
  • the puncture device support and the biosensor chip are integrated, the sample collection port and the puncture device are brought close to each other with a force S.
  • an inclined angle portion is formed at the corner of the tip of the biosensor chip, and a sample collection port is provided at the inclined angle portion.
  • the sample collection port of the biosensor chip and the puncture device are brought closer to each other, and even a small amount of sample can be easily guided to the sample collection port.
  • the biosensor cartridge which is the third feature of the present invention is the biosensor cartridge according to the first or second feature of the present invention described above, wherein the puncture instrument support is configured to attach the biosensor chip. It is integrated with the biosensor chip so as to be sandwiched from the front and back.
  • the puncture instrument support and the biosensor chip are combined and integrated, and the sample collection port and the tip of the biosensor chip are easily close to each other.
  • the biosensor cartridge that is the fourth feature of the present invention is the biosensor chip and the puncture device support according to any one of the first to third features of the present invention.
  • the tip of the puncture device is provided with an elastic body that encloses a puncture opening formed in the subject by the tip of the puncture device and forms a space necessary for sample collection.
  • the puncture port and the sample collection port provided at the tip of the biosensor chip are connected by a space formed by an elastic body. Can be collected
  • this biosensor cartridge it is possible to prevent the puncture device from protruding from the distal end surface of the elastic body before use, thereby protecting the puncture device and protecting the user. Can do. Furthermore, it is possible to prevent the puncture device from protruding from the distal end surface of the elastic body when it is discarded after use, and this allows safe and proper disposal with the force S.
  • the biosensor cartridge that is the fifth feature of the present invention is characterized in that, in the fourth feature of the present invention, at least the distal end surface of the elastic body has adhesiveness.
  • the tip surface of the elastic body since at least the tip surface of the elastic body has adhesiveness, the surface in contact with the subject has adhesiveness, and the elastic body is in close contact with the subject. Therefore, it is possible to prevent the puncture position from shifting and to ensure the sample collection.
  • the elastic body is not limited to the case where only the tip surface has adhesiveness, but when the elastic body itself has adhesiveness or when the adhesive is kneaded into the elastic body, it is coated with the adhesive. The method etc. are mentioned.
  • the sample is collected by the biosensor cartridge described above, puncture and sample collection can be performed in a series of operations, and the biosensor as in the conventional case.
  • the sample can be collected easily and reliably without having to align the sample sampling port of the chip with the puncture port.
  • the measurement can be easily performed in a short time, so that the burden on the subject can be reduced.
  • the sample collection port provided at one end of the biosensor chip and the axis of the puncture device are configured to intersect at an appropriate angle, the sample collection port is used as the puncture port. Since they can be very close to each other, it is possible to provide a biosensor cartridge and a biosensor device that can easily collect even a small amount of sample through the sample collection port and can perform a reliable test.
  • FIG. 1 is an explanatory diagram of a schematic longitudinal section in an embodiment of a biosensor cartridge according to the present invention.
  • (B) is an explanatory diagram of a substantially horizontal cross section in an embodiment of a biosensor cartridge according to the present invention.
  • FIG. 3 is a cross-sectional view showing a main part in an embodiment of a biosensor cartridge according to the present invention.
  • FIG. 4 is a schematic plan view showing an embodiment of a biosensor device according to the present invention.
  • FIG. 5 (A) to (C) are explanatory views showing an operation of measuring a blood glucose level by using the biosensor device which is effective in the present invention.
  • FIG. 6 is an exploded perspective view showing a conventional biosensor chip.
  • FIG. 1 (A) is a longitudinal sectional view of the essential part of the embodiment of the biosensor cartridge of the present invention as seen from the side
  • FIG. 1 (B) is the elasticity in the embodiment of the biosensor cartridge of the present invention
  • Fig. 2 is a view from the tip direction with the body removed (viewed in the direction B in Fig. 1 (A)).
  • FIG. 2 is an exploded perspective view of the biosensor chip and the elastic body.
  • Figure 3 shows the It is a principal part expanded sectional view in Ming embodiment.
  • FIG. 4 is a block diagram showing an embodiment of the biosensor device of the present invention.
  • 5 (A) to 5 (C) are a series of explanatory views showing a sample collecting operation using the biosensor device which is effective in the present invention.
  • a biosensor cartridge 10 includes a biosensor chip 11 having a sample collection port 13 for collecting a sample at the tip, a puncture device support 28, and the like. It is the structure which was combined and integrated.
  • the puncture device support 28 has a puncture device 12 fixed to one end thereof.
  • the puncture device support 28 is integrated with the biosensor chip 11 so that the tip 12a of the puncture device 12 protrudes from the tip 11a side of the biosensor chip 11 and sandwiches the biosensor chip 11. Yes.
  • An elastic body 20 is provided so as to surround the puncture device 12.
  • an inclined angle portion l ib having an angle of approximately 45 degrees is formed at the corner of the tip 11a of the biosensor chip 11, and the sample collection port 13 is opened at the inclined angle portion l ib.
  • the opening of the sampling port 13 faces the puncture device 12 and faces it.
  • the center line F of the hollow reaction part 15 constituting the opening of the sample collection port 13 and the axis C of the puncture device 12 intersect with each other at an angle of about 45 degrees, for example. It is in place.
  • the elastic body 20 is formed with a sealed semi-open space 23 that encloses a puncture opening formed in the subject M by the puncture device 12. Further, as shown in FIGS. 2 and 3, the elastic body 20 includes the tip 1 la of the sensor chip 11 and the tip of the puncture device support 28. The surface 25 in contact with the end 28a is joined by an adhesive or the like.
  • puncture device 12 is a generic term for a needle, a lancet needle, a force needle, and the like, and is preferably composed of a biodegradable material! /.
  • the biosensor chip 11 includes two substrates 16a, 16b extending from the inclined angle portion l ib of the tip 11a to a portion where the two detection electrodes 18a, 18b face each other. And the hollow reaction part 15 is formed by the spacer layer 17.
  • This hollow reaction part 15 (! /, One end on the left side in FIG. 3) opens to the inclined angle part 11b to constitute the sampling port 13. That is, blood D (see FIG. 5C) collected by puncturing the subject M with the tip 12a of the puncture device 12 is introduced from the sample collection port 13 to the hollow reaction unit 15.
  • the hollow reaction part 15 is formed by the substrates 16a and 16b and the detection electrodes 18a and 18b on both upper and lower surfaces, and the spacer layer 17 cut into a predetermined shape has a side wall of about 45 degrees (center). A rectangular space is formed in which the line F is inclined at approximately 45 degrees.
  • the detection electrodes 18a and 18b are appropriately exposed. For example, an enzyme and a mediator are fixed immediately above or in the vicinity of the detection electrodes 18a and 18b in the hollow reaction part 15 in the blood D.
  • a reagent 14 is provided that reacts with the glucose to generate an electric current. Therefore, the hollow reaction part 15 is a part where, for example, blood D, which is a sample collected from the sample collection port 13, undergoes a biochemical reaction with the reagent 14.
  • an insulating material film is selected.
  • the insulating material ceramics, glass, paper, biodegradable material (for example, polylactic acid microorganism production) Polyester), polychlorinated butyl, polypropylene, polystyrene, polycarbonate, acrylic resin, polybutylene terephthalate, polyethylene terephthalate (PET) and other thermoplastic resins, epoxy resins and other thermosetting resins, UV curable resins and other plastics.
  • PET resins include Melinex Nya Tetron (trade name, manufactured by Teijin DuPont Films Ltd.), Nore Miller (trade name, manufactured by Toray Industries, Inc.), and the like.
  • Examples of the reagent 14 include enzymes such as glucose oxidase (GOD), glucose dehydrogenase (GDH), cholesterol oxidase, uricase, and electron acceptors.
  • GOD glucose oxidase
  • GDH glucose dehydrogenase
  • cholesterol oxidase cholesterol oxidase
  • uricase uricase
  • electron acceptors For example, dulcose for measuring the amount of darcose in blood.
  • a glucose oxidase layer, a glucose oxidase electron acceptor (mediator) mixture layer, a glucose oxidase albumin mixture layer, a darcos oxidase electron acceptor albumin mixture layer, or the like is formed in this portion.
  • these layers are formed by using an enzyme other than darcose oxidase, such as glucose dehydrogenase.
  • a buffering agent, a hydrophilic polymer or the like may be included in the drug as an additive.
  • the elastic body 20 attached to the tip 11a of the biosensor chip 11 and the tip 28a of the puncture device support 28 has, for example, a sealed semi-open space 23 in the center.
  • the cylindrical thing which has the through-hole 22 for forming can be illustrated.
  • the through hole 22 is configured to allow the puncture device 12 to pass through and to allow the sample (blood D) to reach the sample collection port 13.
  • the through hole 2 is formed to be slightly larger than the outer diameter of the puncture device 12 (inner diameter W1), and further, from the space force through hole 22 on the specimen M side (lower side in the figure). Also configured with a larger inner diameter (W2)!
  • the opening of the sealed semi-open space 23 is configured to be large, the positional relationship necessary for collecting the sample D can be reliably maintained between the puncture port and the open space of the insulator 20 at the time of puncturing. Also, unexpected contact due to misalignment between the sample D and the elastic body 20 is avoided, and troubles such as the sample D oozing out to the contact portion can be avoided.
  • the sealed semi-open space 23 has a so-called through-hole 22 in which the so-called through-hole 22 has a raised portion 26 in which the wall surface around the through-hole 22 is raised.
  • the sealed half The blood D that has flowed into the open space 23 first contacts the raised portion 26 around the through hole 22 and is guided to the through hole 22. Therefore, since blood D first contacts the location near the through hole 22 in the sealed semi-open space 23, the introduction of blood D into the sampling port 13 can be stabilized, and the blood D can be unexpectedly exposed to the outside. Bleeding can be prevented.
  • the thickness (t) of the elastic body 20 is configured to be able to reliably cover the tip 12 a of the puncture device 12.
  • the material of the elastic body 20 is not particularly limited as long as it has elasticity.
  • the elastic body 20 is made of a polymer such as silicone, urethane, acrylic rubber, or a single polymer or copolymerized polymer such as ethylene or styrene. Rubber or sponge, polyethylene such as polyethylene and polypropylene, polyester such as polyethylene terephthalate and polybutylene terephthalate, polytetrafluoroethylene and PFA which is a copolymer of perfluoroalkoxyethylene and polyfluoroethylene, etc. Can be used.
  • At least the distal end surface 21 of the elastic body 20 that is in contact with the subject M has a force composed of a material such as adhesive silicone rubber or acrylic rubber, and the elastic body has the adhesive 24. It is desirable to have or be coated with adhesive 24.
  • the adhesive 24 is not particularly limited as long as the elasticity is not impaired. As a result, the adhesion between the elastic body 20 and the subject M can be improved, the puncture position force can be prevented from shifting, and the sealed semi-open space 23 can be reliably formed.
  • the inner peripheral surface of the through hole 22 has a force using a hydrophilic material, or at least the inner peripheral surface is subjected to a hydrophilic treatment. This facilitates passage of blood D to be collected, and even a small amount of blood D can be reliably collected.
  • the sensor chip 11 and the puncture device support 28 and the elastic body 20 are securely fixed with an adhesive.
  • an adhesive so as to crush the gap.
  • this adhesive can prevent blood D collected from the joint from leaking.
  • the biosensor device 30 includes a biosensor cartridge 10 and a measuring device 31 that obtains information on blood D collected by connecting to the detection electrodes 18a and 18b of the biosensor cartridge 10. And a protective cap 36 for the biosensor cartridge.
  • the configuration of the biosensor cartridge 10 is as described above, and parts that are the same as those of the biosensor cartridge 10 described above are denoted by the same reference numerals, and the description thereof is omitted here.
  • the measuring instrument 31 includes a power source 32, a control device 33, a terminal insertion unit 34, and a display unit 35, which are connected to each other.
  • the rear end portion 11c of the biosensor chip 11 of the biosensor force trough 10 is inserted and fixed in the terminal insertion portion 34, and the detection electrode 18a exposed at the rear end portion 11c of the biosensor chip 11 is fixed. 18b are electrically connected.
  • the biosensor device 30 is small in size, for example, a subject can be held with one hand.
  • the rear end portion 11c of the biosensor chip 11 of the biosensor cartridge 10 is inserted into the terminal insertion portion 34 of the measuring device 31 to be fixed and electrically connected. Turn on the power 32 of the biosensor device 30 and check that it is operating normally.
  • the biosensor device 30 is held, the protective cap 36 is pressed against the subject, the puncture site is congested, and the biosensor cartridge 10 is attached to the tip 11a of the biosensor cartridge 10.
  • the elastic body 20 is brought into contact with the blood collection point of the subject M.
  • the pressure sensitive adhesive 24 is coated on the tip surface 21 of the elastic body 20, the positional shift is prevented in the subsequent work.
  • the biosensor cartridge 10 is pressed against the subject M. I will. As a result, the elastic body 20 is crushed and the distal end 12a of the puncture device 12 protrudes from the distal end of the elastic body 20 to puncture the subject M.
  • the force pressing the biosensor cartridge 10 is weakened.
  • the elastic body 20 returns to its original state (the state of FIG. 5A) by its restoring force.
  • the tip 12a of the puncture device 12 is removed from the subject M.
  • the inside of the sealed semi-open space 23 including the puncture port is temporarily under negative pressure, blood D easily flows out from the puncture port.
  • the blood D is guided to the sampling port 13 along the inner peripheral surface of the through hole 22 and the puncture device 12 by the surface tension and capillary action. Collected.
  • the collected blood D is introduced into the hollow reaction part 15.
  • the sample collection port 13 is located in the sealed semi-open space 23 together with the puncture port formed by the puncture device 12, the blood D can be easily and reliably collected without moving the biosensor cartridge 10. Can be collected.
  • the biosensor device 30 When a predetermined amount of blood is collected as described above, the biosensor device 30 is separated from the subject M, and the measurement result is displayed on the display unit 35.
  • the blood D introduced into the hollow reaction unit 15 reacts with the reagent 14, and the current value or charge value (charge amount) data measured by the detection electrodes 18 a and 18 b is sent to the control device 33.
  • a calibration curve data table is stored in the control device 33, and the blood glucose level is calculated based on the measured current value (charge value).
  • the measurement result is displayed on the display unit 35.
  • the blood glucose level can be expressed as a numerical value.
  • a drive mechanism for puncturing, in addition to puncturing by pressing the biosensor cartridge 10 against the subject M, for example, a drive mechanism may be used.
  • Examples of the drive mechanism for puncturing a subject with a puncture device include a panel and a motor. By using these drive mechanisms, the time required for puncture can be shortened, and pain during puncture can be reduced.
  • the volume of the hollow reaction part 15 is preferably 1 L (microliter) or less, particularly preferably 300 nL (nanoliter) or less. With such a small hollow reaction part 15, a sufficient blood volume of the subject can be collected even if the diameter of the puncture device 12 is small. Preferably, the diameter is 1000 m or less.
  • the puncture device 12 by preventing the puncture device 12 from protruding from the distal end surface 21 of the elastic body 20 before use, the puncture device 12 and the user can be protected. Further, when the puncture device 12 does not protrude from the distal end surface 21 of the elastic body 20 when it is discarded after use, it can be disposed of safely and properly.
  • biosensor cartridge of the present invention is not limited to the above-described embodiment, and can be appropriately modified and improved.
  • the force in which the inclined angle portion l ib of the negative sensor chip 11 is inclined by approximately 45 degrees is not limited to this, and can be set to an appropriate angle. .
  • the sample collection port may be provided only at the corner of the tip.
  • the hollow reaction part 15 has a rectangular shape inclined approximately 45 degrees, and its inclination angle and shape can be changed as appropriate.
  • the sensor cartridge is not limited to this.
  • the present invention may have a configuration in which this elastic body is not provided.
  • the biosensor cartridge according to the present invention opens in the direction intersecting the axis of the tip of the sample-collecting mouth force puncture device provided at one end of the biosensor chip. Therefore, since the sample collection port can move the sample collection port closer to the puncture port formed by the tip of the puncture device than before, even a small amount of sample can be collected easily by the sample collection port. And a reliable inspection can be performed. In addition, according to the present invention, then, it is possible to provide a biosensor device that can perform a reliable test.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Cette invention propose une cartouche de biocapteur qui peut réduire la quantité d'un échantillon devant être prélevé et nécessaire pour effectuer une mesure, afin de réduire la charge sur des utilisateurs, et qui peut facilement prélever l'échantillon à travers un orifice perforé sans nécessiter l'étape consistant à amener un orifice de prélèvement d'échantillon à s'approcher de l'orifice perforé, pour la mesure, et un appareil de biocapteur. Un orifice de prélèvement d'échantillon (13) disposé à une extrémité d'une puce de biocapteur (11) est ouvert dans une direction qui traverse la ligne d'axe d'un outil de perforation (12). En vertu de cette structure, l'orifice de prélèvement d'échantillon (13) peut être amené à s'approcher d'un orifice perforé formé par la pointe de l'outil de perforation (12) à une position plus proche de l'orifice perforé par rapport à la position atteinte par l'état antérieur de la technique. Selon la structure ci-dessus, même une petite quantité d'un échantillon peut être facilement prélevée à travers l'orifice de prélèvement d'échantillon (13), et un examen fiable peut être effectué.
PCT/JP2007/071332 2006-11-21 2007-11-01 Cartouche de biocapteur et appareil de biocapteur WO2008062648A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-314188 2006-11-21
JP2006314188A JP4894039B2 (ja) 2006-11-21 2006-11-21 バイオセンサカートリッジ及びバイオセンサ装置

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WO2008062648A1 true WO2008062648A1 (fr) 2008-05-29

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
US9839384B2 (en) 2005-09-30 2017-12-12 Intuity Medical, Inc. Body fluid sampling arrangements
US9897610B2 (en) 2009-11-30 2018-02-20 Intuity Medical, Inc. Calibration material delivery devices and methods
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
US10433780B2 (en) 2005-09-30 2019-10-08 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
US10772550B2 (en) 2002-02-08 2020-09-15 Intuity Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578014A (en) * 1992-04-29 1996-11-26 Erez; Uri Skin piercing devices for medical use
JP2001515377A (ja) * 1996-12-06 2001-09-18 アボツト・ラボラトリーズ 診断テスト用血液の採取方法及び装置
JP2003533323A (ja) * 2000-05-26 2003-11-11 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 体液採取システム
US6783502B2 (en) * 2001-04-26 2004-08-31 Phoenix Bioscience Integrated lancing and analytic device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578014A (en) * 1992-04-29 1996-11-26 Erez; Uri Skin piercing devices for medical use
JP2001515377A (ja) * 1996-12-06 2001-09-18 アボツト・ラボラトリーズ 診断テスト用血液の採取方法及び装置
JP2003533323A (ja) * 2000-05-26 2003-11-11 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 体液採取システム
US6783502B2 (en) * 2001-04-26 2004-08-31 Phoenix Bioscience Integrated lancing and analytic device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US11986298B2 (en) 2005-09-30 2024-05-21 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US9839384B2 (en) 2005-09-30 2017-12-12 Intuity Medical, Inc. Body fluid sampling arrangements
US10433780B2 (en) 2005-09-30 2019-10-08 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US10441205B2 (en) 2005-09-30 2019-10-15 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US10842427B2 (en) 2005-09-30 2020-11-24 Intuity Medical, Inc. Body fluid sampling arrangements
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
US11045125B2 (en) 2008-05-30 2021-06-29 Intuity Medical, Inc. Body fluid sampling device-sampling site interface
US11399744B2 (en) 2008-06-06 2022-08-02 Intuity Medical, Inc. Detection meter and mode of operation
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
US11986293B2 (en) 2008-06-06 2024-05-21 Intuity Medical, Inc. Medical diagnostic devices and methods
US11553860B2 (en) 2008-06-06 2023-01-17 Intuity Medical, Inc. Medical diagnostic devices and methods
US9897610B2 (en) 2009-11-30 2018-02-20 Intuity Medical, Inc. Calibration material delivery devices and methods
US11933789B2 (en) 2009-11-30 2024-03-19 Intuity Medical, Inc. Calibration material delivery devices and methods
US11002743B2 (en) 2009-11-30 2021-05-11 Intuity Medical, Inc. Calibration material delivery devices and methods
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US11382544B2 (en) 2011-08-03 2022-07-12 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US11672452B2 (en) 2011-08-03 2023-06-13 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US11051734B2 (en) 2011-08-03 2021-07-06 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback

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