WO2008053055A1 - Vacuna profiláctica contra la tuberculosis - Google Patents
Vacuna profiláctica contra la tuberculosis Download PDFInfo
- Publication number
- WO2008053055A1 WO2008053055A1 PCT/ES2007/000583 ES2007000583W WO2008053055A1 WO 2008053055 A1 WO2008053055 A1 WO 2008053055A1 ES 2007000583 W ES2007000583 W ES 2007000583W WO 2008053055 A1 WO2008053055 A1 WO 2008053055A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- use according
- tuberculosis
- medicament
- cell wall
- virulent strain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Definitions
- the current vaccine used in the preventive treatment against tuberculosis is based on bacteria of the strain called BCG (Bacillus Calmette-Guerin), an attenuated variant of M. bovis.
- the vials obtained after the lyophilization process contain the immunotherapeutic agent comprising the cell wall fragments of MTB-C, and are generally stored at very low temperatures, for example at -70 ° C.
- the object of The invention is the use of the immunotherapeutic agent comprising cell wall fragments of a virulent strain of MTB-C for the preparation of a medicament for the prophylactic treatment of tuberculosis, that is, for the preparation of a prophylactic vaccine against tuberculosis.
- the medicament for the prophylactic treatment of tuberculosis comprises the immunotherapeutic agent based on cell wall fragments and, optionally, pharmaceutically acceptable diluents, adjuvants and / or excipients.
- the medicament may be in the form of phosphate buffer saline, aqueous solution, emulsion, or in the form of liposomes.
- the sterols that are used in the preparation of liposomes can be, among others, cholesterol and bile salts.
- mice were divided into three groups of 12 animals each, and underwent the following vaccination protocol: 1) Without vaccination (Control group),
- mice were infected by aerosol with said virulent strain at the ninth week of the experiment by placing it in a Middelbrook aerosol infection apparatus that provided an approximate inoculum of 10-50 viable bacilli in the lungs of the mice.
- the number of viable bacilli in the lungs was determined at 3 weeks after the aerosol infection of the animals (week 12 of the experiment) by incubating serial dilutions of lung homogenates in Middelbrook 7H11 agar for 4 weeks at 37 ° C. Homogenization of the lung was carried out in the presence of 1 ml of double distilled water.
- Table I express the logarithm of the Colony Forming Units (CFU) by me that have been identified in the lung:
- the supernatants were frozen and after remaining in that state for a minimum of 24 hours, the interferon- ⁇ content was analyzed by applying the double sandwich ELISA technique and using a specific monoclonal antibody for murine interferon- ⁇ (Diaclone).
- mice inoculated with the virulent strain was able to induce a response against the ESAT-6 antigen.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL07822990T PL2090318T3 (pl) | 2006-10-30 | 2007-10-17 | Profilaktyczna szczepionka przeciwko gruźlicy |
NZ576489A NZ576489A (en) | 2006-10-30 | 2007-10-17 | Prophylactic tuberculosis vaccine |
EP07822990A EP2090318B1 (en) | 2006-10-30 | 2007-10-17 | Prophylactic tuberculosis vaccine |
AU2007316091A AU2007316091B2 (en) | 2006-10-30 | 2007-10-17 | Prophylactic tuberculosis vaccine |
JP2009533888A JP2010508254A (ja) | 2006-10-30 | 2007-10-17 | 結核の予防ワクチン |
CN2007800405684A CN101600455B (zh) | 2006-10-30 | 2007-10-17 | 预防性结核疫苗 |
MX2009004258A MX2009004258A (es) | 2006-10-30 | 2007-10-17 | Vacuna profilactica contra la tuberculosis. |
US12/447,584 US9289483B2 (en) | 2006-10-30 | 2007-10-17 | Prophylactic tuberculosis vaccine |
DK07822990.3T DK2090318T3 (da) | 2006-10-30 | 2007-10-17 | Profylaktisk tuberkulosevaccine |
UAA200905336A UA104126C2 (ru) | 2006-10-30 | 2007-10-17 | Профилактическая вакцина от туберкулеза |
CA2667965A CA2667965C (en) | 2006-10-30 | 2007-10-17 | Prophylactic tuberculosis vaccine |
BRPI0715297A BRPI0715297B8 (pt) | 2006-10-30 | 2007-10-17 | vacina profilática contra tuberculose |
RU2009120522/15A RU2526910C2 (ru) | 2006-10-30 | 2007-10-17 | Профилактическая вакцина от туберкулеза |
ES07822990T ES2393007T3 (es) | 2006-10-30 | 2007-10-17 | Vacuna profilactica contra la tuberculosis |
IL198357A IL198357A (en) | 2006-10-30 | 2009-04-23 | Vaccine to prevent tuberculosis |
ZA2009/02937A ZA200902937B (en) | 2006-10-30 | 2009-04-29 | Prophylactic tuberculosis vaccine |
HK10105629.6A HK1138786A1 (en) | 2006-10-30 | 2010-06-08 | Prophylactic tuberculosis vaccine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200602754A ES2307402B1 (es) | 2006-10-30 | 2006-10-30 | Vacuna profilactica contra la tuberculosis. |
ESP200602754 | 2006-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008053055A1 true WO2008053055A1 (es) | 2008-05-08 |
Family
ID=39343853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2007/000583 WO2008053055A1 (es) | 2006-10-30 | 2007-10-17 | Vacuna profiláctica contra la tuberculosis |
Country Status (20)
Country | Link |
---|---|
US (1) | US9289483B2 (es) |
EP (1) | EP2090318B1 (es) |
JP (1) | JP2010508254A (es) |
KR (1) | KR20090087874A (es) |
CN (1) | CN101600455B (es) |
AU (1) | AU2007316091B2 (es) |
BR (1) | BRPI0715297B8 (es) |
CA (1) | CA2667965C (es) |
DK (1) | DK2090318T3 (es) |
ES (2) | ES2307402B1 (es) |
HK (1) | HK1138786A1 (es) |
IL (1) | IL198357A (es) |
MX (1) | MX2009004258A (es) |
NZ (1) | NZ576489A (es) |
PL (1) | PL2090318T3 (es) |
PT (1) | PT2090318E (es) |
RU (1) | RU2526910C2 (es) |
UA (1) | UA104126C2 (es) |
WO (1) | WO2008053055A1 (es) |
ZA (1) | ZA200902937B (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2335177A1 (es) * | 2008-09-19 | 2010-03-22 | Archivel Farma, S.L. | Agente inmunoterapeutico apropiado para la profilaxis primaria de la tuberculosis. |
WO2013104943A1 (en) | 2012-01-12 | 2013-07-18 | Archivel Farma, S.L. | Mtb-c vaccine against asthma |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104744476B (zh) | 2008-12-08 | 2017-04-12 | 吉利德康涅狄格公司 | 咪唑并吡嗪syk抑制剂 |
CN104059073B (zh) | 2008-12-08 | 2017-04-12 | 吉利德康涅狄格公司 | 咪唑并哌嗪syk抑制剂 |
PL2661253T3 (pl) | 2011-01-04 | 2017-08-31 | Archivel Farma, Sl | Preparat liposomowy odpowiedni do leczenia lub zapobiegania gruźlicy |
EP2471511A1 (en) | 2011-01-04 | 2012-07-04 | Archivel Farma, SL | Liposome formulation suitable for treating or preventing tuberculosis |
CN113950479A (zh) | 2019-02-22 | 2022-01-18 | 克洛诺斯生物股份有限公司 | 作为syk抑制剂的缩合吡嗪的固体形式 |
WO2023062066A1 (en) | 2021-10-14 | 2023-04-20 | Archivel Farma, S.L. | Liposome formulations for treatment of active tuberculosis |
Citations (5)
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WO2000021983A2 (en) * | 1998-10-08 | 2000-04-20 | Statens Serum Institut | Tuberculosis vaccine and diagnostic reagents based on antigens from the mycobacterium tuberculosis cell |
RU2153354C1 (ru) * | 1999-03-31 | 2000-07-27 | Московский городской научно-практический центр борьбы с туберкулезом | Вакцина против туберкулеза |
US20020127700A1 (en) * | 2000-12-08 | 2002-09-12 | Ying Zhang | Methods for improved diagnosis and treatment of mycobacterial infections |
WO2003063897A1 (en) * | 2002-01-29 | 2003-08-07 | Modi, Rajiv, Indravadan | Method of providing prophylaxis for tuberculosis in hiv positive individuals |
ES2231037A1 (es) | 2003-10-31 | 2005-05-01 | Archivel Technologies, Sl | Agente inmunoterapico util para el tratamiento combinado de la tuberculosis en asociacion con otros farmacos. |
Family Cites Families (11)
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US6641814B1 (en) * | 1997-04-02 | 2003-11-04 | Statens Serum Institut | Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis |
RU2093046C1 (ru) * | 1996-05-06 | 1997-10-20 | Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН | Лечебно-профилактическая пищевая композиция "гербамарин" |
US6284255B1 (en) * | 1996-08-29 | 2001-09-04 | Genesis Research & Development Corporation Limited | Compounds and methods for treatment and diagnosis of mycobacterial infections |
ATE402413T1 (de) * | 1997-03-03 | 2008-08-15 | Adcock Ingram Ltd | Eine zusammensetzung, die eine trägerkomponente und eine gereinigte mykobakterielle zellwandkomponente enthält, und ihre verwendung zur verhinderung, behandlung und diagnose von erkrankungen |
US7037510B2 (en) * | 1997-04-18 | 2006-05-02 | Statens Serum Institut | Hybrids of M. tuberculosis antigens |
US6420342B1 (en) * | 2000-05-08 | 2002-07-16 | N.V. Nutricia | Nutritional preparation comprising ribose and medical use thereof |
EP2196473A1 (en) | 2001-07-04 | 2010-06-16 | Health Protection Agency | Mycobacterial antigens expressed during latency |
EP1463526A4 (en) * | 2001-08-02 | 2006-08-30 | Univ New York | EARLY DETECTION OF MYCOBACTERIAL DISEASES USING PEPTIDES |
WO2003018053A1 (en) | 2001-08-22 | 2003-03-06 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Vaccine against mycobacterial-induced diseases |
CN1467221A (zh) * | 2002-07-14 | 2004-01-14 | 虹 王 | 结核杆菌cfp-10、esat-6与cd40l融合疫苗的制备及应用 |
ES2335177B1 (es) * | 2008-09-19 | 2011-02-28 | Archivel Farma, S.L. | Agente inmunoterapeutico apropiado para la profilaxis primaria de la tuberculosis. |
-
2006
- 2006-10-30 ES ES200602754A patent/ES2307402B1/es active Active
-
2007
- 2007-10-17 ES ES07822990T patent/ES2393007T3/es active Active
- 2007-10-17 EP EP07822990A patent/EP2090318B1/en active Active
- 2007-10-17 KR KR1020097008486A patent/KR20090087874A/ko not_active Application Discontinuation
- 2007-10-17 AU AU2007316091A patent/AU2007316091B2/en not_active Ceased
- 2007-10-17 PL PL07822990T patent/PL2090318T3/pl unknown
- 2007-10-17 JP JP2009533888A patent/JP2010508254A/ja active Pending
- 2007-10-17 PT PT07822990T patent/PT2090318E/pt unknown
- 2007-10-17 DK DK07822990.3T patent/DK2090318T3/da active
- 2007-10-17 NZ NZ576489A patent/NZ576489A/en not_active IP Right Cessation
- 2007-10-17 CA CA2667965A patent/CA2667965C/en active Active
- 2007-10-17 MX MX2009004258A patent/MX2009004258A/es active IP Right Grant
- 2007-10-17 US US12/447,584 patent/US9289483B2/en active Active
- 2007-10-17 RU RU2009120522/15A patent/RU2526910C2/ru active
- 2007-10-17 WO PCT/ES2007/000583 patent/WO2008053055A1/es active Application Filing
- 2007-10-17 UA UAA200905336A patent/UA104126C2/ru unknown
- 2007-10-17 CN CN2007800405684A patent/CN101600455B/zh active Active
- 2007-10-17 BR BRPI0715297A patent/BRPI0715297B8/pt active IP Right Grant
-
2009
- 2009-04-23 IL IL198357A patent/IL198357A/en not_active IP Right Cessation
- 2009-04-29 ZA ZA2009/02937A patent/ZA200902937B/en unknown
-
2010
- 2010-06-08 HK HK10105629.6A patent/HK1138786A1/xx not_active IP Right Cessation
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WO2000021983A2 (en) * | 1998-10-08 | 2000-04-20 | Statens Serum Institut | Tuberculosis vaccine and diagnostic reagents based on antigens from the mycobacterium tuberculosis cell |
RU2153354C1 (ru) * | 1999-03-31 | 2000-07-27 | Московский городской научно-практический центр борьбы с туберкулезом | Вакцина против туберкулеза |
US20020127700A1 (en) * | 2000-12-08 | 2002-09-12 | Ying Zhang | Methods for improved diagnosis and treatment of mycobacterial infections |
WO2003063897A1 (en) * | 2002-01-29 | 2003-08-07 | Modi, Rajiv, Indravadan | Method of providing prophylaxis for tuberculosis in hiv positive individuals |
ES2231037A1 (es) | 2003-10-31 | 2005-05-01 | Archivel Technologies, Sl | Agente inmunoterapico util para el tratamiento combinado de la tuberculosis en asociacion con otros farmacos. |
Non-Patent Citations (9)
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D.P. PAL ET AL., INDIAN J. MED. RES., vol. 65, 1977, pages 340 - 345 |
DATABASE WPI Week 200102, Derwent World Patents Index; AN 2001-014156, XP003022729 * |
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See also references of EP2090318A4 |
SINHA S. ET AL.: "Proteome Analysis of the Plasma Membrane of Mycobacterium tuberculosis", COMPARATIVE AND FUNCTIONAL GENOMICS, vol. 3, 2002, pages 470 - 483, XP002998683 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2335177A1 (es) * | 2008-09-19 | 2010-03-22 | Archivel Farma, S.L. | Agente inmunoterapeutico apropiado para la profilaxis primaria de la tuberculosis. |
WO2010031883A1 (es) | 2008-09-19 | 2010-03-25 | Archivel Farma, S.L. | Agente inmunoterapéutico apropiado para la profilaxis primaria de la tuberculosis |
EP2332571A1 (en) * | 2008-09-19 | 2011-06-15 | Archivel Farma, S.l. | Immunotherapeutic agent suitable for the primary prophylaxis of tuberculosis |
US20110268788A1 (en) * | 2008-09-19 | 2011-11-03 | Archivel Farma, S.L. | Immunotherapeutic agent suitable for the primary prophylaxis of tuberculosis |
CN102264389A (zh) * | 2008-09-19 | 2011-11-30 | 阿尔西维尔法尔玛公司 | 适用于结核病初级预防的免疫治疗剂 |
US8795719B2 (en) | 2008-09-19 | 2014-08-05 | Archivel Farma, S.L. | Immunotherapeutic agent suitable for the primary prophylaxis of tuberculosis |
RU2544125C2 (ru) * | 2008-09-19 | 2015-03-10 | Арчивель Фарма, С.Л. | Иммунотерапевтическое средство, предназначенное для первичной профилактики туберкулеза |
WO2013104943A1 (en) | 2012-01-12 | 2013-07-18 | Archivel Farma, S.L. | Mtb-c vaccine against asthma |
RU2602771C2 (ru) * | 2012-01-12 | 2016-11-20 | Арчивель Фарма, С.Л. | Вакцина мбтк против астмы |
Also Published As
Publication number | Publication date |
---|---|
NZ576489A (en) | 2012-02-24 |
PT2090318E (pt) | 2012-11-14 |
EP2090318A4 (en) | 2010-01-27 |
KR20090087874A (ko) | 2009-08-18 |
US9289483B2 (en) | 2016-03-22 |
ES2393007T3 (es) | 2012-12-17 |
ES2307402B1 (es) | 2009-09-30 |
EP2090318B1 (en) | 2012-08-08 |
ES2307402A1 (es) | 2008-11-16 |
AU2007316091A1 (en) | 2008-05-08 |
AU2007316091B2 (en) | 2013-06-27 |
CA2667965A1 (en) | 2008-08-05 |
HK1138786A1 (en) | 2010-09-03 |
UA104126C2 (ru) | 2014-01-10 |
RU2526910C2 (ru) | 2014-08-27 |
JP2010508254A (ja) | 2010-03-18 |
BRPI0715297A2 (pt) | 2015-02-03 |
CN101600455A (zh) | 2009-12-09 |
CN101600455B (zh) | 2013-08-07 |
IL198357A (en) | 2013-03-24 |
CA2667965C (en) | 2016-08-23 |
BRPI0715297B1 (pt) | 2019-01-29 |
MX2009004258A (es) | 2009-05-11 |
RU2009120522A (ru) | 2013-01-20 |
IL198357A0 (en) | 2011-08-01 |
EP2090318A1 (en) | 2009-08-19 |
ZA200902937B (en) | 2010-02-24 |
PL2090318T3 (pl) | 2013-03-29 |
US20100068258A1 (en) | 2010-03-18 |
BRPI0715297B8 (pt) | 2021-05-25 |
DK2090318T3 (da) | 2012-11-19 |
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