WO2008041460A1 - Éliminateur d'oxygène actif, agent d'activation et promoteur de la production de collagène comprenant chacun du cacalol - Google Patents

Éliminateur d'oxygène actif, agent d'activation et promoteur de la production de collagène comprenant chacun du cacalol Download PDF

Info

Publication number
WO2008041460A1
WO2008041460A1 PCT/JP2007/067795 JP2007067795W WO2008041460A1 WO 2008041460 A1 WO2008041460 A1 WO 2008041460A1 JP 2007067795 W JP2007067795 W JP 2007067795W WO 2008041460 A1 WO2008041460 A1 WO 2008041460A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
plant
oil
roll
acid
Prior art date
Application number
PCT/JP2007/067795
Other languages
English (en)
Japanese (ja)
Inventor
Kazutoshi Shindo
Hiroaki Kitazawa
Masaru Kitagawa
Shuhei Yamamoto
Michiko Suzuki
Atsushi Sogabe
Original Assignee
Toyo Boseki Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Boseki Kabushiki Kaisha filed Critical Toyo Boseki Kabushiki Kaisha
Priority to JP2008517667A priority Critical patent/JPWO2008041460A1/ja
Publication of WO2008041460A1 publication Critical patent/WO2008041460A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans

Definitions

  • the first invention of the present invention relates to a drug excellent in active oxygen scavenging action. More details
  • a second invention of the present invention relates to an activator containing a power roll or an extract of the genus Cacalia, and in particular, a power calorie that is effective in activating skin fibroblasts and preventing aging. And cosmetics, quasi-drugs, pharmaceuticals, and foods and drinks containing extracts of plants belonging to the genus Cacalia.
  • a third invention of the present invention relates to a method for producing a plant extract containing a power roll.
  • a fourth invention of the present invention relates to a collagen production promoter comprising a plant extract containing a power roll as an active ingredient.
  • Reactive oxygen species generally react with components such as adjacent lipids, nucleic acids, and proteins in a living body that has high chemical reactivity, and cause oxidative damage that leads to various diseases.
  • Reactive oxygen causes collagen fiber cross-linking, DNA damage, tissue damage due to chain radical generation, skin and living body aging, inflammation, smooth muscle damage in myocardial infarction, deterioration of liver damage, brain tissue It is known to cause dementia due to the destruction of.
  • the reactive oxygen species scavenger having the activity of efficiently eliminating these active oxygen species is a component of components contained in the living body, foods, pharmaceuticals, agricultural chemicals, etc. It is useful as a protective agent against oxidative degradation and is expected to be used practically in the food industry, especially in the marine products, health foods, and nutritional foods, as well as in the fields of pharmaceuticals, agricultural chemicals, and cosmetics.
  • vitamins C, E, carotenoids and natural products such as dibutylhydroxytoluene, butylhydroxybisole and synthetic compounds are effective.
  • these substances only erase one or two reactive oxygen species, their active oxygen scavenging activity is not sufficient.
  • antioxidants have a problem in stability when blended with cosmetics or the like having low stability, and have poor practicality.
  • the power roll is one of the typical maple extract components, and 5,6,7,8-tetrahydrone-3,4,5-trimethylnaphtho [2,3-b] furan-9 -It is a non-polyphenolic fat-soluble substance with an all structure.
  • power rolls are also contained in extracts from plants other than Momijigasa. For example, Cacalia
  • Non-patent document 5 Adenostyloides (Non-patent document 5), Cacalia auriculata, Non-patent document 6), Ligularia virgaur ea (Non-patent document 7), Psacalium radulifolium (Non-patent document 3) and the like have been reported.
  • Non-patent Document 1 Power rolls are known to have DPPH (1, l-Diphenyl-2-picrylhydrazyl) scavenging ability (Non-patent Document 1), lipid peroxide inhibiting ability (Non-patent Document 2), etc. .
  • Non-patent Document 3 antibacterial action
  • Non-Patent Document 4 hypoglycemic action
  • the superoxide, hydrogen peroxide, and the scavenging action against active oxygen species such as singlet oxygen and the stability generated in the living body were not known at all.
  • the skin is composed of epidermal cells, fibroblasts, and extracellular matrices such as elastin and collagen that support these extracellular skin structures.
  • extracellular matrices such as elastin and collagen that support these extracellular skin structures.
  • moisture retention, flexibility, and elasticity are ensured by maintaining the homeostasis of the interaction between these skin tissues, and the skin has a firmness and wrinkles in appearance, and is maintained in a fresh state.
  • the extracellular matrix and fibroblast function are particularly weakened.
  • the skin's flexibility and moisturizing function are reduced, and the skin loses its habit and becomes rough. Aging symptoms such as wrinkles and dullness occur.
  • plant-derived activators include sesame seeds, peonies, chili peppers, toki, dokudami, bakumondo (Patent Document 4), almonds, dandelion, instantonito, sensyuyu, assembly, sohakhi, tonin, carrot, hop, mukuge, Extracts of gyokuinin (patent document 5), ginger family turmeric genus (patent document 6), and blossom genus Hanayasuri (patent document 7) are known. Some of these are used in quasi-drugs and cosmetics as activators and anti-aging agents, but no activators that exhibit satisfactory effects have been obtained.
  • Non-patent document 7 Psacalium radulifolium (Non-patent document 3) and the like have been reported.
  • Momijigasa (Cacalia delphiniifolia Sieb et Zucc) is also known as Sidke, Sidki, Sidkina, Shindoki, Kinoshita, Toukichi, Tokichina, Sudoke, Sitgi, Sudoke, and is widely distributed in Japan. It is eaten as a wild vegetable. Momijigasa extract is known to have a whitening effect (Patent Document 8).
  • One of the main components of Momijigasa is force carol.
  • Non-patent Document 2 It is known that a powerful roll has excellent antioxidant ability that suppresses lipid peroxidation (Non-patent Document 2). As the physiological action of force rolls, antibacterial action (Non-patent Document 3) and hypoglycemic action (Non-Patent Document 4) have been reported. However, the activation effect of the force roll on cells and the anti-aging effect were not known at all.
  • the skin is composed of epidermal cells, fibroblasts, and extracellular matrices such as elastin and collagen that support these extracellular skin structures.
  • extracellular matrices such as elastin and collagen that support these extracellular skin structures.
  • the interaction of these skin tissues maintains homeostasis, ensuring moisture retention, flexibility, and elasticity, and the skin is maintained in a fresh state with tension and wrinkles. It is.
  • aging, UV rays, dryness, stress, etc. cause a decrease in the function of the extracellular matrix and fibroblasts in particular, resulting in a decrease in skin flexibility and moisturizing function, and the skin loses its habits. Aging symptoms such as roughening, wrinkles and dullness occur.
  • plant-derived activators examples include sesame seeds, peonies, capsicum, toki, dokudami, batamando (patent document 4), almonds, dandelion, instantonitoko, senkyu, assembly, sohakhi, tonin, carrot, hop, mukuge, Extracts of gyokuinin (patent document 5), ginger family turmeric genus (patent document 6), and genus genus genus (patent document 7) are known.
  • plant secondary metabolites include essential oils, taste components, And alkaloids are known.
  • the “power roll” as used in the present invention is one of typical maple extract components, and includes 5, 6, 7, 8-tetrahydro 3, 4, 5-trimethyl naphtho [2, 3— b] Non-polyphenolic (non-flavonoid) plant secondary metabolite with furan 9-ol structure.
  • power rolls are also contained in extracts from plants other than Momijigasa.
  • Cacalia adenostyloides Non-Patent Document 5
  • Cacalia auriculata Non-Patent Document 6
  • Non-patent document 7 Psacalium radulifolium (Non-patent document 3) and the like have been reported. (Additional quotation from Invention 2)
  • Momijigasa is also known as Sidke, Sidki, Sidkina, Shindoki, Kinoshita, Toukichi, Tokichina, Sudoke, Sitogi, Sudoke, and is widely distributed in the country and is eaten as a wild vegetable. Yes.
  • a whitening effect is known for the extract of Japanese maple (Patent Document 8).
  • a powerful roll exists as one of the main components of the extract of Momijigasa, and it is known that the powerful roll has an excellent antioxidant ability to suppress lipid peroxidation! /, Ru (non-patent document 2).
  • As physiological effects of force rolls antibacterial action (Non-patent Document 3) and hypoglycemic action (Non-Patent Document 4) have been reported.
  • an extract obtained by extracting a plant with an organic solvent or the like often contains a large amount of chlorophyll, which is a pigment unique to photosynthetic organisms. Chlorophyll is readily converted chemically and enzymatically into degradation products such as pheophorbide. Since this chlorophyll degradation product is one of the substances causing photosensitivity that causes inflammation of the skin and the like by sunlight, it is necessary to remove chlorophyll and its degradation products from the extract (Non-patent Document 8). In addition, plant extracts that contain a lot of black-filled pigments are more susceptible to deterioration during storage due to sunlight, fluorescent light, etc. It was an important technology to remove the power as much as possible, more economically. However, the known Japanese maple extract is simply extracted with an organic solvent such as methanol and then concentrated under reduced pressure (Patent Document 8). There is no method for reducing the chlorophyll concentration and increasing the power roll concentration. It has never been known before.
  • a substance having an extracellular matrix production promoting action for example, a licorice leaf extract (patent document 9), a lotus germ extract (patent text) having an action of promoting collagen production. 10), hydrolyzed potato protein (Patent Document 11), bamboo leaf extract or hawthorn fruit extract (Patent Document 12), etc., some of which are used as a collagen production promoter in the pharmaceutical department.
  • Patent Document 9 a licorice leaf extract
  • a lotus germ extract having an action of promoting collagen production. 10
  • Patent Document 11 hydrolyzed potato protein
  • Patent Document 12 bamboo leaf extract or hawthorn fruit extract
  • Patent Document 1 Japanese Patent Laid-Open No. 62-84024
  • Patent Document 2 JP-A 63-188697
  • Patent Document 3 Japanese Patent Laid-Open No. 03-141299
  • Patent Document 4 Japanese Patent Laid-Open No. 10-45615
  • Patent Document 5 Japanese Patent Laid-Open No. 10-36279
  • Patent Document 6 Japanese Patent Publication No. 2004-75632
  • Patent Document 7 JP-A-2005-89375
  • Patent Document 8 Japanese Unexamined Patent Publication No. 05-345705
  • Patent Document 9 Japanese Unexamined Patent Publication No. 2000-191498
  • Patent Document 10 Japanese Unexamined Patent Application Publication No. 2002-29980
  • Patent Document 11 Japanese Unexamined Patent Publication No. 2005-263689
  • Patent Document 12 Japanese Unexamined Patent Publication No. 2006-160629
  • Non-patent literature l Revista de la sociedad Quimica de Mexico., 47, 160 (2003)
  • Non-patent literature 2 Bioscience Biotechnology and Biochemistry, 68, 1393 (2004)
  • Non-patent literature 3 Journal of Natural Products, 64, 432 ( 2001)
  • Non-Patent Document 4 Journal of Natural Products, 62, 1088 (1999)
  • Non-Patent Document 5 Chemical & Pharmaceutical Bulletin, 33, 4792 (1985)
  • Non-Patent Document 6 Khimiya Prirodnykh Soedienli, 5, 643 (1989)
  • Non-Patent Document 7 Phytochemistry, 30, 3132 (1991)
  • Non-Patent Document 8 Food & Food Ingredients J. Jpn, 172, 29 (1997)
  • FIG. 5 is a diagram showing the amount of power rolls in the precipitate when the water content of ethanol is changed.
  • FIG. 6 is a diagram showing the amount of power roll in the supernatant when the water content of ethanol is changed.
  • FIG. 7 shows a production scheme of Example 2.
  • FIG. 8 shows the results of confirming the collagen production promoting action on normal human skin fibroblasts by a plant extract containing a power roll.
  • the first invention of the present invention is to solve the conventional problems, to provide an active oxygen scavenger excellent in active oxygen scavenging action, and to provide a highly stable external preparation.
  • the second invention of the present invention is as follows.
  • the purpose of the second invention of the present invention is to provide an activator and an anti-aging agent that are excellent in activation and anti-aging effects on cells, and have safety sufficient to withstand long-term use. To provide cosmetics and quasi-drugs, pharmaceuticals, and foods and drinks.
  • Patent Document 8 the known Japanese maple extract is simply extracted with an organic solvent such as methanol and concentrated under reduced pressure. The concentration of chlorophyll is lowered to increase the strength roll concentration. This method has never been known.
  • the conventional collagen production promoting substance cannot be said to have a sufficient effect, and a new collagen production promoting substance that exhibits a satisfactory effect has been strongly desired.
  • the present invention has been made in view of the above-mentioned problems, and its purpose is to remove chlorophyll from a plant extract obtained from a plant containing a power roll and to increase the power roll concentration. Another object is to provide a method for producing a plant extract, and to provide a collagen production promoter that has a remarkable collagen production promoting action and at the same time has sufficient safety to withstand long-term use.
  • the present inventors have found that the power roll has an erasing action on any active oxygen species such as superoxide, hydrogen peroxide, and singlet oxygen. And having found that the power roll has excellent stability, the first invention of the present invention has been completed. That is, the first invention of the present invention has the following configuration.
  • the active oxygen scavenger characterized by eliminating at least one active oxygen selected from the group consisting of superoxide, hydrogen peroxide, and singlet oxygen.
  • a reactive oxygen scavenger characterized by being a power carol extracted from a plant of the genus Cacalia of (1 1) or (1 2).
  • a reactive oxygen scavenging method comprising scavenging at least one active oxygen selected from the group consisting of superoxide, hydrogen peroxide, and singlet oxygen.
  • (1-11) contains a power roll as an active ingredient
  • a reactive oxygen scavenging method comprising scavenging at least two kinds of active oxygen selected from the group consisting of superoxide, hydrogen peroxide, and singlet oxygen.
  • An active oxygen scavenging method characterized by scavenging superoxide, hydrogen peroxide, and singlet oxygen.
  • the present inventors have found that a maple extract is effective in activating cells, and have completed the second invention of the present invention. . That is, the second invention of the present invention includes the following inventions.
  • the asteraceae plant is a plant belonging to the genus Batrizo (2-1) or (
  • any of the above (2— ;!) to (2-5), the activator according to 1 or the anti-aging agent according to (2-6) A pharmaceutical product characterized by containing.
  • any one of the above (2— ;!) to (2-5), the activator according to item 1, or the anti-aging agent according to (2-6) A food or drink characterized by containing.
  • the present inventors have obtained a secondary extract obtained from a plant extract containing a power roll using an appropriate solvent, which contains the original power roll. It was found that the chlorophyll content was lower than that of the plant extract (third invention), and further, the plant extract containing strong calorie was found to have a collagen production promoting action (fourth invention).
  • the present inventors have completed the third and fourth inventions of the present invention. That is, the third and fourth inventions of the present invention include the following inventions.
  • the third invention of the present invention includes the following inventions.
  • the method includes a step of obtaining a secondary extract from a plant extract containing a power roll using a mixture of water and a hydrophilic organic solvent, and the secondary extract includes the power roll.
  • (3- 2) The plant extract containing a power roll according to (3-1), characterized in that the above steps are repeated until the content of chlorophyll in the secondary extract is below the desired number. Manufacturing method.
  • the hydrophilic organic solvent is selected from the group consisting of ethanol, acetone, isopropyl alcohol, propylene glycol, butylene glycol, and butanol.
  • the mixture of water and a hydrophilic organic solvent used in the step of obtaining the secondary extract is hydrous ethanol having an ethanol content of 45% or more (3
  • the mixture of water and a hydrophilic organic solvent used in the step of removing impurities is hydrous ethanol having an ethanol content of 40% or less.
  • the fourth invention of the present invention includes the following inventions.
  • a cosmetic comprising the collagen production promoter according to (4 10) or (4 11) as an active ingredient.
  • the first invention, the second invention, and the fourth invention have the following configurations.
  • a reactive oxygen scavenger characterized by being a force roll extracted from the power of the plant of the genus Cacalia belonging to the genus Calalia, (5-1) or (5-2).
  • the active oxygen scavenger which is the force Karolka S described in (5-1) or (5-2), a force roll produced by chemical synthesis.
  • a reactive oxygen scavenging method comprising scavenging at least one active oxygen selected from the group consisting of superoxide, hydrogen peroxide, and singlet oxygen.
  • An activator comprising an extract of a genus Cacalia as an active ingredient.
  • the extract of the genus Cacalia contains a force roll (5-1) 1) Activator.
  • a collagen production promoter characterized by being a power carol extracted from a plant of the genus Cacalia belonging to the power carolka described in (5-14).
  • a collagen production promoter characterized by being the force Karolka S described in (5-14), a force roll produced by chemical synthesis.
  • the first invention of the present invention it is possible to provide a highly stable active oxygen scavenger that exerts an effect on a plurality of active oxygen species of superoxide, hydrogen peroxide, and singlet oxygen. s can.
  • active oxygen scavenger of the first invention of the present invention other active oxygen scavengers show scavenging ability only for the active oxygen species in the part, whereas all of these three active oxygen species On the other hand, it has an erasing action. Normally, when a plurality of active oxygen species generated in a living body are used for erasing, it is necessary to use a combination of active oxygen scavengers capable of erasing each.
  • the power roll of the first invention of the present invention can be expected to obtain an effective effect only with the power roll, since it can erase a plurality of active oxygen species.
  • Use of the active oxygen scavenger for the human body and other foods and drinks, pharmaceuticals, cosmetics, whitening agents, fertilizers, feeds, skin external preparations, etc. provides an excellent antioxidant effect, particularly an improvement effect on the storage stability of the product. Antioxidant effect and various disease preventive effects can be obtained.
  • An extract of the Asteraceae plant used as an active ingredient of the activator according to the second invention of the present invention has a significant activation effect on skin fibroblasts. Therefore, the activator according to the second invention of the present invention exhibits an excellent effect as an anti-aging agent. In particular, plants that are eaten as wild plants among the plants belonging to the genus Morris are excellent in safety, and the activator according to the second invention of the present invention is sufficiently resistant to long-term use! / Have an effect
  • a plant extract containing a power roll having a low chlorophyll content can be produced at low cost without performing a complicated operation.
  • the collagen production promoter according to the fourth invention of the present invention is excellent in the effect of promoting collagen production and contains a safe power roll as an active ingredient. Therefore, it is effective when it can withstand long-term use!
  • the genus Cacalia of the present invention refers to a plant belonging to the genus Compositae.
  • the genus Cacalia is
  • the power roll refers to 5,6,7,8-tetrahydride-3,4,5-trimethylnaphtho [2,3-b] furan-9-ol It is a non-polyphenol compound having a structure.
  • the power roll of the present invention is a compound represented by the formula (I).
  • the power roll of the formula (I) that can be used in the first invention of the present invention is a natural product and its derivative, and a chemical compound as long as it meets the purpose of the first invention of the present invention. Either of them may be used. In particular, natural products and their derivatives can be conveniently used for the purposes of the present invention.
  • active oxygen examples include superoxide ( ⁇ ⁇ ichi), hydroxy radical ( ⁇ ⁇ ), hydrope
  • radical species LEO '
  • radical species such as nitric oxide (NO)
  • hydrogen peroxide H 2 O 2
  • Non-radical species such as OOH), hypochlorous acid (HOC1) and ozone (O 2).
  • the power roll has high! /, Active oxygen relative to a plurality of reactive oxygen species of superoxide, hydrogen peroxide, and singlet oxygen.
  • the present inventors have found an scavenging effect and nevertheless have provided an active oxygen scavenger having high stability.
  • a power roll has DPPH elimination ability, lipid peroxide inhibition ability and the like.
  • active oxygen species such as superoxide, hydrogen peroxide, and singlet oxygen that are actually generated in the living body. .
  • antioxidants have a problem in stability when blended with cosmetics or the like having low stability, and are not practical.
  • an active oxygen scavenger having a high active oxygen scavenging effect for a plurality of active oxygen species and having high stability can be provided.
  • the plant for obtaining the power roll of the first invention of the present invention is not particularly limited.
  • Asteraceae is preferable.
  • the Asteraceae plants include the genus Dendranthema, Aster, Calend dula, Callistephus, Carthamus, Cosmos, and Dahlia. ), Gazania, Gerbera, Helianth us, Senecio, Zinnia, Achillea, Ageratum, Ammobium, Daisies (Bellis), Centa urea, Cirsium, Coreopsis, Dimorp hotheca, Echinops, Felicia, Guilaldia (Gaillar dia), Miyako genus (Gymnaster), wheat genus (Helichrysum), Rhodanse genus (Heli pterum), riatris (Liatris), Rudbeckia, Stokesia, Tagetes, bats Powers such as (Cacalia), Miricacalia, and Syneilesis. Among them, the bat power S is desirable.
  • the plants of the genus Komorisou include bat Morisou, Momijigasa, Nikkomori, Tamabuki, Innuduna, Izkanikomori, Okanikomori, Taimingasa, Kushikomorisou, Tebacomomi Jigasa, Nishinoyama Taimingasa, Mikamimori Etc.
  • Momijigasa which is preferred by edible plants, is suitable.
  • Momijigasa is also known as Sidke, Sidoki, Sidkina, Shindoki, Kinoshita, Toukichi, Tokichina, Sudoke, Sitgi, Sudoke, and is widely distributed in the family Asteraceae. It is eaten as a wild vegetable.
  • the plant tissue for obtaining the power roll is not particularly limited, but can be obtained from the whole plant or a partial tissue.
  • Sites that can be obtained are not particularly limited, but include whole trees, flowers, buds, ovary, fruits, leaves, cotyledons, stems, buds, roots, seeds, dried seeds, embryos, germs, roots and the like.
  • the plant may be extracted from a raw state, a frozen state, or a lyophilized state.
  • the extraction operation is preferably performed from a freeze-dried state.
  • it may be crushed first.
  • a mixer, a homogenizer, a mortar or the like may be used.
  • the freeze-dried product may be crushed into powder after the freeze-drying operation.
  • the crushed plant body is extracted using a solvent.
  • Extraction methods include extraction by impregnation at room temperature, in a cooled or heated state, extraction using a distillation method such as steam distillation, compression method to obtain an extract by pressing, supercritical fluid or subcritical fluid
  • a distillation method such as steam distillation
  • compression method to obtain an extract by pressing
  • supercritical fluid or subcritical fluid may be used alone or in combination of two or more.
  • 5 to 100 ml of solvent is used for the finely cut raw material lg for 1 hour to 1 month, preferably 1 to 5 days, at room temperature or under heating. It is desirable.
  • the solvent used for the extraction is not particularly limited as long as the active ingredient is effectively extracted, but is water or an organic solvent miscible with water such as a lower alcohol such as ethanol, Alternatively, a mixed solution thereof, or an organic solvent immiscible with water, such as ethyl acetate, may be used.
  • Examples include monohydric alcohols such as dichloromethane, methanolol, isopropanol, isobutanol, n-hexanol, methinoreaminoreanolol, 2-ethynolebutanol, n-octyl alcohol, Glycerin, ethylene glycolate, ethylene glycol monomethino ethenore, propylene glycol nore, propylene glycol mono methino ethenore, propylene glycol nole mono chineno ethenore, triethylene glycol, 1,3-butylene glycol, Polyhydric alcohols such as hexylene glycol or derivatives thereof, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl-n-propyl ketone, esters such as isopropyl acetate, ethyl ether, isopropyl ether , Ether
  • Examples include animal fats such as vegetable oils, beef tallow, pork tallow and whale oil.
  • a polar solvent to which inorganic salts such as phosphate buffered saline are added and a solvent to which a surfactant is added can be used, and there is no particular limitation.
  • extraction with either water and / or alcohol is particularly preferable.
  • the extraction operation may be performed in stages. For example, extraction is performed with an organic solvent that is miscible with water, such as a lower alcohol such as ethanol, and the mixture is concentrated with an evaporator. May be separated.
  • an organic solvent that is miscible with water such as a lower alcohol such as ethanol
  • the mixture is concentrated with an evaporator. May be separated.
  • components having a tyrosinase inhibitory action, a melanin production inhibitory action, and an antioxidant action are extracted in both the organic layer and the aqueous layer, and may be used for different purposes.
  • the components of the water layer can be expected to be used when an anti-oxidant that has an affinity for water is desired, such as facial cleansing applications, skin lotion applications, and use applications.
  • the force roll obtained in this way may be used as it is, as long as it does not lose its effect.
  • the obtained extract in order to increase the concentration of the force roll, which is an active ingredient in the extract, the obtained extract can be further concentrated, liquid-liquid distribution, adsorption chromatography, normal phase or reverse phase chromatography, etc., if desired. It is also possible to attach to the means.
  • the plant from which a powerful roll is obtained may be a processed plant product.
  • the processing methods include impregnation method, distillation method, squeezing method, ultrasonic method, supercritical fluid method using water, organic solvent, water and organic solvent mixture at low temperature, room temperature and warm conditions. Extract the extract using the subcritical fluid method. Furthermore, it includes processed products such as fermenting plants and extracts collected from plants. Examples include plant extracts and plant extracts.
  • a method such as 65, 319 (2005) can be exemplified.
  • a power roll obtained by chemical synthesis can also be suitably used as an active ingredient of the active oxygen scavenger according to the present invention.
  • the use form of the power roll according to the first invention of the present invention is arbitrary, for example, a refined product with an increased content of the power roll, which is an active ingredient, or an active ingredient as a crude extract. Some power rolls can be used as pure products.
  • the power roll according to the first invention of the present invention is added as an active oxygen scavenger to cosmetics, foods and drinks, pharmaceuticals, etc.
  • the effect expected by the compound is effective.
  • the total amount is from 0.0000000001 to 1%, preferably ⁇ 0.0001% to 0.01%.
  • the active oxygen scavenger in the first invention of the present invention includes, in addition to the essential power roll of the present invention, bases and additives that are usually used in cosmetics as shown below, for example, Oils and fats, waxes, mineral oils, fatty acids, alcohols, esters, metal soap, gum And water-soluble polymer compounds, surfactants, vitamins, amino acids, whitening agents, moisturizers, microbial culture metabolites, hydroxyacetic acid, inorganic pigments, UV absorbers, astringents, antibacterial agents, bactericides, disinfectants, hair It can be used in combination with agents, fragrances, pigments / colorants, sweeteners, nutrition enhancers, hair restorers, animal and plant extracts, antioxidants, anti-inflammatory agents and the like.
  • bases and additives that are usually used in cosmetics as shown below, for example, Oils and fats, waxes, mineral oils, fatty acids, alcohols, esters, metal soap, gum And water-soluble polymer compounds, surfactants, vitamins,
  • the fats and oils include apogad oil, almond oil, wikiyo oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, kaka-age ⁇ , power mitsule oil, power lot oil, cucumber oil, Beef tallow, beef tallow fatty acid, cucumber nut oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil , Palm kernel oil, owl, coconut oil, beef tallow, lard, hydrogenated oil, hydrogenated castor oil.
  • waxes examples include beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelillaro, montan wax, shellac wax and the like.
  • mineral oils examples include liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, polyethylene powder, squalene, squalane, and pristane.
  • fatty acids include lauric acid, myristic acid, normitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid
  • synthetic fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.
  • alcohols include natural alcohols such as ethanol, isopropanol, laurino-leanolone, cetanol, stearino-leno-conole, oleino-leano-reconole, lanolinano-reconole, cholesterol, and phytosterol.
  • natural alcohols such as ethanol, isopropanol, laurino-leanolone, cetanol, stearino-leno-conole, oleino-leano-reconole, lanolinano-reconole, cholesterol, and phytosterol.
  • Synthetic alcohols such as 2-hexyl decanol, isostearyl decanol, 2-octyldodecanol, ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether , Diethylene glycol monomethylenoate, diethylene glycol monoethylenoate, polyethylene glycol, propylene oxide, propylene glycol, polypro Pyrene glycol, 1,3-butylenegri
  • Examples include cornore, glycerin, chinenoreanoleconore, pentaerythritol, sonorebitonore, mannitol, glucose, sucrose and other polyhydric alcohols.
  • Esters include isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, lactic acid
  • Examples include cetyl, myristyl lactate, jetyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, and propylene glycol dioleate.
  • Examples of the metal soap include aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, and zinc undecylenate.
  • gums and water-soluble polymer compounds include gum arabic, benzoin rubber, dammar gum, guayata fat, Irish moss, kala gum, tragacanth gum, kilob gum, quinseed, agar, casein, dextrin, gelatin, pectin, Starch, carrageen, chitosan salt, sulfated chitin, phosphorylated chitin, alginic acid and its salt, hyaluronic acid and its salt, chondroitin sulfate, heparin, ethyl cellulose, methylcellulose
  • Rosenorelose crystalline senorelose, polyvinylenorenoleconole, polyvinino methinoreatenore, polybulol pyrrolidone, polybull metaaterylate, polyacrylic acid salt, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or cross-linking thereof Polymers, carboxybule polymers, polyethyleneimine and the like can be mentioned.
  • Surfactants include anionic surfactants (carboxylates, sulfonates, sulfate esters, phosphate esters), cationic surfactants (ammine salts, quaternary ammonium salts), amphoteric surfactants.
  • Agents carboxylic acid type amphoteric surfactant, sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant), nonionic surfactant (ether type nonionic surfactant, Ether ester type nonionic surfactant , Ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants (natural surfactants, derivatives of protein hydrolysates, polymer surfactants) Agents, surfactants containing titanium 'key, fluorocarbon surfactants, and the like.
  • Vitamins include retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), and thiamin hydrochloride and thiamine sulfate (vitamin B group).
  • Vitamin B1 riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, ascorbic acid in the vitamin C group And its derivatives, in vitamin D group, ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotachysterol, in vitamin E group, tocopherol and its derivatives, ubiquinones, in vitamin K group , Huitnadione (vitamin K1), Menaquinone (vitamin K2), Me Dione (vitamin K3), and the like menadiol (vitamin K4).
  • Amino acids include Norin, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cystine, cystine, tyrosine, proline, hydroxyproline, asparagine
  • acids glutamic acid, hydroxylysine, arginine, ornithine, histidine, and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate, and pyrrolidone carboxylic acid.
  • a whitening agent L-ascorbic acid and its derivatives, hydroquinone and its derivatives, tranexamic acid, lucinol, edetic acid and its derivatives, and placenta extract, t-AMC HA, acerola extract, age extract, ellagic acid or its derivatives, Flaming extract, chamomile extract, force bud flower extract (urea), kiwi extract, glutathione, tocotrienol, ferulic acid, raspberry ketone, noresinol, walurshkis, pyridoxine dipalmitate, io, kojic acid or its derivatives, darcosamine or Derivatives thereof, hydroxy cinnoic acid or derivatives thereof, dartathione, arginium extract, gonon extract, sohakhi extract, psycho extract, boufu extract, garlic mushroom mycelium culture or extract thereof, linden extract, Peach leaf extract, age extract, ku
  • Moisturizers include sodium pyridonecarboxylate, glycol, glycerin, glucose, maltose , Maltitol, sucrose, fructose, xylitonor, sonorebitoren, manoletotriose, threitol, erythritole, amylolytic sugar-reduced alcohol, sonolebithonole, and polyhydric alcohols include ethylene glycol, 1,4-butylene glycol, diglycerin, triglycerin , Tetraglycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-propanedio , Serine, glycine, threonine, alanine, collagen, hydrolyzed collagen, hydronectin, fibronectin, keratin, elastin, royal jelly, chondroitin sulfate heparin, glyce oral phospholipid,
  • microbial culture metabolites include yeast extract, zinc-containing yeast extract, germanium-containing yeast extract, selenium-containing yeast extract, magnesium-containing yeast extract, rice fermentation extract, Euglena extract, and skim milk powder.
  • yeast extract zinc-containing yeast extract
  • germanium-containing yeast extract germanium-containing yeast extract
  • selenium-containing yeast extract magnesium-containing yeast extract
  • rice fermentation extract Euglena extract
  • skim milk powder examples include lactic acid fermented products.
  • Examples of the ⁇ -hydroxy acid include glyconolic acid, citrate, malic acid, tartaric acid, and lactic acid.
  • anhydrous caustic acid magnesium silicate, talc, kaolin, bentonite, my strength, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate
  • magnesium carbonate yellow iron oxide, red iron oxide, black iron oxide, gundiio, chromium oxide, chromium hydroxide, carbon black, calamine and the like.
  • an ultraviolet absorber ⁇ -aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative
  • examples include camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, oxybenzone, benzophenone, guaiazurene, shikonin, baicalin, noikalein, and berberine.
  • lactic acid, tartaric acid, succinic acid, succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenol sulfonate, potassium aluminum sulfate, resorcin, secondary chloride examples thereof include iron and tannic acid.
  • ovata extract As an antibacterial agent, ovata extract, halocarban, chlorophenesine, lysozyme chloride, alkyldiaminoethylglycine hydrochloride, isopropylmethylphenol, thymol, hexacyclophene, berberine, thixolone, salicylic acid and their derivatives, Benzoic acid, sodium benzoate, paraoxybenzoic acid ester, parachloromethcresol, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol, carboxylic acid, sorbic acid, potassium sorbate, hexaclonal fenphene, chlorhexidine chloride, trichloro Oral carbanilide, photosensitizer, bis (2-pyridinorethio 1-oxide) zinc, thianthol, hinokitiol, triclosan, trichlorohydroxydiphenenoleethenole,
  • a disinfectant for example, as a disinfectant, atalinol, io, benzalkonium chloride, benzethonium chloride, methyl rosaniline chloride, cresol monole, calcium dalconate, chlorhexidine dalconate, sulfamine, mercurochrome, latatoferrin or its addition Moisture breakdown products.
  • a hair preparation selenium disulfide, alkylisoquinolinium bromide, zinc pilichn, bifuenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water
  • examples include potassium bromate, sodium bromate, and thiodaricholic acid.
  • fragrance natural animal fragrances such as Jiakou, Civet, Castrium, Ambergris, Anise essential oil, Angri essential oil, Iran essential oil, Iris essential oil, Wikiyo essential oil, Orange essential oil, Kananga essential oil, Power Laue essential oil , Cardamom essential oil, guayata wood essential oil , Cumin essential oil, black letter essential oil, key skin essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, Western Hearts Power essential oil, Otsuki perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, Baturi lily essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil,
  • a red cabbage dye for example, as a colorant / colorant, a red cabbage dye, a red rice dye, an akane dye, an anato dye, a squid ink dye, a turquoise dye, an enji dye, a krill dye, an amber dye, a caramel, a gold, a silver, a gardenia dye, Corn pigment, onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigo mulberry pigment, purple imo pigment, purple potato pigment, lac pigment, rutin, etc. Is mentioned.
  • sweeteners include sugar, sweet tea, fructose, arabinose, galactose, xylose, mannose, maltose, honey, glucose, miraculin, monelin and the like.
  • examples of the nutrient fortifier include shell calcined calcium, cyanobacamine, yeast, wheat germ, soybean germ, egg yolk powder, hemicellulose, heme iron and the like.
  • pentadecanoic acid glyceride coleus extract, gentian extract, macca extract, roya jelly extract, kumazasa extract, t-flavanone, 6-penzinoreaminopurine, assembly extract, carpronium chloride, minoxidil, finasteride , Adenosine, nicotinamide, mulberry root extract, dio extract, and 5-aminolevulinic acid.
  • Animal and plant extracts include Asenjak (Asen Yaku), Ashitaba, Acerola, Altea, Al Niki, avocado, Amachiya (Amacha), Aloe, Aloe Vera, Nettle, Ichiyo (Ginkgo Leaves, Ginkgo), Wikiyo (Ayaka) , Turmeric (Usukin), Uspasaishin (spicy), Japanese apricot (Plum), Vulture mouth oak, mulberry, Neubara (Nonjutsu), hikikoshi (life-prolonging grass), ogi (Twilight), Koganebana (Ogon), yamazakura (cherry skin) ), Kihada (Yellow), Oulen (Huang Ren), Ginseng (Ginseng), Oto Girisou (Little Cut Grass), Odorico Sou, Dutch Garashi, Orange, Itohimehagi (Distance), Tubo Dasa (Summer Blossom), Tsur
  • an ultraviolet absorber amyl benzoate, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomenthyl salicylate, benzyl quine, paramethoxykelate 2 —Ethoxyethyl, normethoxykelate octyl, diparamethoxykelate mono-2-ethyl glyceryl hexanoate, isopropyl paramethoxykelate, diisopropyl'diisopropylcinnamate ester mixture, urocanic acid, urocanic acid ethyl, hydroxy Methoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, Hydr
  • Antioxidants include ascorbic acid and its salts, stearic acid ester, tocopherol and its ester derivatives, nordihydroguasertenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), para Examples include hydroxyanisole, propyl gallate, sesamol, sesamorin, gossypol.
  • Anti-inflammatory agents include glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, isopropylaminocaproic acid and its salts, allantoin, lysozyme chloride, guaizlene, methyl salicylate, ⁇ -oryzanol, and antioxidants include ⁇ Carotene, 13 carotene, y carotene, lycopene, cryptoxanthine, noretin, zeaxanthin, isazexane Carotenoids such as tin, rhodoxanthine, capsanthin, crocetin; 1,4-diazacyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-dipheninoreisobenzofuran, ⁇ -tocopherol , / 3 tocopherol, ⁇ tocopherol, d to
  • the active oxygen scavenger according to the first invention of the present invention can be used as an external preparation by blending it into cosmetics, quasi drugs, medical supplies, hygiene products, and pharmaceuticals.
  • the dosage form is not limited, and ampoules , Capsules, powders, granules, pills, tablets, solids, solutions, gels, bubbles, emulsions, creams, ointments, sheets, mousses, bath preparations, and the like.
  • cosmetics, quasi-drugs, medical products, hygiene products, and pharmaceuticals include, for example, internal use external preparations, lotions, emulsions, creams, ointments, lotions, oils, packs, etc.
  • Examples include refreshing agents, gargles, liquid odors, deodorants, sanitary products, sanitary cotton, and wet tissue.
  • the cosmetic composition containing the active oxygen scavenger of the present invention can also be used as an ointment or a poultice.
  • Examples of the foods and drinks include soft drinks, carbonated drinks, nutrition drinks, fruit drinks, lactic acid drinks, ice cream, ice sherbet, power, frozen ice confectionery, soba, udon, harusame, gyoza skin , Sweet potato skins, Chinese rice cakes, instant rice cakes, rice cakes, candy, gum, chocolate, tablets, snacks, biscuits, jelly, jams, creams, baked goods, pans, etc.
  • Seafood such as clams, tuna, sardines, shrimp, bonito, sano, whales, oysters, saury, squid, akagai, scallops, arabi, yu, ichura, tokobushi, and other marine products such as power, maboko, ham, sausage ⁇ Dairy products such as processed livestock foods, processed milk, fermented milk, salad oil, tempura oil, margarine, mayonnaise, shortening, whipped cream, dressing, etc.
  • Fat and oil processed foods, seasonings such as sauces, sauces, curry, stew, oyakodon, rice cakes, miscellaneous cooking, Chinese rice bowl, bonito, tempura, eel rice, hayashi rice, oden, mabodorf, beef bowl, meat sauce, egg soup,
  • Examples include retort bouch foods such as omelet rice, dumplings, shiyumai, non-nog, meat bonore, various forms of health / nutritional supplements, health functional foods, tablets, capsules, drinks, troches and the like.
  • the active oxygen scavenger according to the first invention of the present invention is preferably applied to humans, but is applied to animals other than humans as long as each effect can be expected. That's it.
  • the active oxygen scavenger of the first invention of the present invention is not particularly limited, but nonionic surfactant, lower alcohol, polyhydric alcohol, olive oil, squalane, fatty acid It can be used by dissolving in natural fats and oils.
  • Nonionic surfactants include, for example, sorbitan fatty acid esters (for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monolaurate).
  • sorbitan fatty acid esters for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monolaurate.
  • hydrophilic hydrophilic nonionic surfactant examples include ⁇ -sorbitan fatty acid esters (for example, ⁇ -sorbitan monooleate, ⁇ -sorbitan monostearate, ⁇ -sorbitan monooleate, ⁇ —Sorbit fatty acid esters (eg, ⁇ —Sorbit monolaurate, ⁇ —Sorbit monooleate, ⁇ ⁇ —Sorbit pentaoleate, ⁇ —Sorbit monostearate, etc.); Glycerin fatty acid esters (eg, ⁇ -glycerol monostearate, ⁇ -glycerol monoisostearate, ⁇ -monooleate, etc.); ⁇ -fatty acid esters (eg, ⁇ -distearate) , ⁇ —Monozi ⁇ ⁇ ⁇ -alkynole ethers (e.g., ⁇ -lauryl ether, ⁇ -oleyl ether, ⁇ -stearyl
  • Tetra POP-ethylene diamine amine condensates for example, Tetronic, etc.
  • POE-castor oil-cured castor Oil derivatives eg POE—castor oil, POE—hardened castor oil, POE—hardened castor oil monoisoss) AOETO, POE—hardened castor oil triisostearate, POE—hardened castor oil monopyroglutamic acid monoisostearic acid diester, POE—hardened castor oil maleic acid, etc.
  • POE honey bees' lanolin derivatives (eg, POE—sorbite beeswax etc.) ); Al Powered olamide (eg coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE propylene glycol fatty acid ester; POE-alkylamine; POE fatty acid amide; sucrose fatty acid ester; alkyl ethoxydimethylamine oxide
  • Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
  • polyhydric alcohol examples include dihydric alcohols (for example, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycolanol, tetramethylene glycolanol, 2, 3 Butylene glycolanol, pentamethylene glycolanol, 2 butene 1,4 dianol, hexylene glycolanol, octylene glycol, etc .; Trivalent alcohol (eg, glycerin, trimethylolpropane, etc.); Tetravalent alcohol (eg, 1, 2, 6 hexanetriol, etc.
  • dihydric alcohols for example, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycolanol, tetramethylene glycolanol, 2, 3 Butylene glycolanol, pentamethylene glycolanol, 2 butene 1,4 dianol, hexylene glycolanol,
  • pentaerythritol, etc. pentavalent alcohol
  • pentavalent alcohol eg, xylitol, etc.
  • hexavalent alcohol eg, sonorebitanol, mannitol, etc.
  • polyhydric alcohol polymer eg, diethylene glycol, diethylene glycol, etc.
  • divalent alcohol alkyl ethers eg, ethylene glycol monomethyl ether, ethylene glycol monomethenole
  • Etherenole ethylene glycol monobutinole etherenole, ethylene glycol mononomonomono etherenole, ethylene glycol mononomonohexenoreethenore, ethylene glyconoremono 2-methylenohexen
  • Dihydric alcohol ether esters for example, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glyconomonomonobutylenoate acetate, ethylene glycol monomonoinoatenoate acetate, ethylene glyconoresazia
  • Bait ethyleneglycolenoresuccinate, diethylene glycol monoethyl ether acetate, diethylene Recall monobutyl etherate acetate, propylene glycol monomethinoate etherate acetate, propylene glyconomonoethylenoate acetate, propylene glycol monopropinoate acetate, propylene glycol monophenyl ether acetate, etc.
  • glycerin mono Alkyl ethers for example, minomino ethanol, cerakil alcohol, batyl alcohol, etc.
  • sugar alcohols for example, sonorebitole, multitonole, manoletotrios
  • oils avocado oil, olive oil, sesame oil, camellia oil, evening primrose oil, turtle oil, madame demian nut oil, corn oil, mink oil, rapeseed oil, egg yolk oil, persic oil, oat germ oil , Southern power oil, castor oil, Amani oil, safflower oil, cottonseed oil, Eno oil, soybean oil, peanut oil, tea seed oil, cocoa oil, rice bran oil, kiri oil, jojoba oil, cocoa butter, coconut oil, Animal and vegetable oils such as horse oil, palm oil, palm kernel oil, beef tallow, sheep fat, pork tallow, lanolin, whale wax, beeswax, carnauba roux, moclaw, candelilla roux, squalane, and hardened oils thereof.
  • Examples of higher fatty acids include lauric acid, myristic acid, normitic acid, oleic acid, linoleic acid, linolenic acid, stearic acid, behenic acid, 12-hydroxystearic acid, isostere.
  • Examples include aspartic acid, undecinic acid, tolic acid, eicosapentaenoic acid, docosahexaenoic acid.
  • Examples of the higher alcohols include laurinorenolechol, cetyl alcohol, stearinorenole monole, beheninoleanoreconole, myristinoleanore: 3-nore, reino reinorenorenore, ceto stearinorenoreconole, Jojobano Reconole, Lanolinano Reconole, Notino Reano Renore, 2-Desino Rete Tethecinore, Cholesterol Nore, Phytosterol Nore, Isostearinore Alcohol, etc.
  • Synthetic esters include, for example, cetyl octanoate, octyldodecyl myristate, isopropyl myristate, myristyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, decyl orenate, dimethyl octanoate, cetyl lactate, Examples include myristyl lactate.
  • the silicone include chain polysiloxanes such as dimethyl polysiloxane and methinorefinole polysiloxane, cyclic polysiloxanes such as decamethylenocyclopolysiloxane, and three-dimensional network structures such as silicone resins.
  • activation is intended to maintain or enhance cell function or activity. As a result, it is possible to suppress a decrease in cell function and cell activity, that is, to suppress cell aging. Therefore, “activator” is synonymous with “cell activator” and has utility as “anti-aging agent”.
  • activation, anti-aging in skin cells refers to reducing wrinkles and sagging of the skin by reducing the deterioration of the function of skin cells associated with the accumulation of structural changes in the substrata membrane due to aging and photoaging. This refers to the prevention and improvement of curing, etc., and maintaining the skin's elasticity and youthful healthy skin.
  • the activator according to the second invention of the present invention is not particularly limited as long as it contains an extract of an Asteraceae plant as an active ingredient, and among them, an activator contains an extract of a genus Camellia plant as an active ingredient. preferable.
  • the Asteraceae plants include the genus Dendranthema, Aster, Calend dula, Callistephus, Carthamus, Cosmos, and Dahlia. ), Gazania, Gerbera, Helianth us, Senecio, Zinnia, Achillea, Agratam Genus Ageratum), Kaizoic genus (Ammobium), Daisies (Bellis), Cageno urea, Cirsium, Coreopsis, Dimorp hotheca, Echinops , Felicia, Gaillar dia, Gymnaster, Helichrysum, Rholiperum, Liatris, Rudbeckia, Strokesia (Stokesia), Tagetes genus (Cacalia), moss genus (Miricacalia), genus Syneilesis, etc. Among them, bat genus power S is desirable.
  • the plants of the genus Komorisou include bat Morisou, Momijigasa, Nikkomori, Tamabuki, Innuduna, Izkanikomori, Okanikomori, Taimingasa, Kushikomorisou, Tebacomomijigasa, Nishinoyama Taimingasa, Mikamimori Etc.
  • Momijigasa which is preferred by edible plants, is suitable.
  • Momijigasa is also known as Sidke, Sidki, Sidkina, Shindoki, Kinoshita, Toukichi, Tokichina, Sudoke, Sitgi, Sudoke, and is a asteraceae plant widely distributed in Japan and eaten as a wild vegetable. Has been.
  • the extract used in the second invention of the present invention can be obtained using the whole plant of Asteraceae as a raw material. It is also possible to separate the plant body from large rhizomes, stems, and leaves to obtain each partial force and extract, and the extract may be obtained using a combination of each part as a raw material. Since the present inventors have found that among the roots, stems, and leaves of Momijigasa, particularly the leaves have many active ingredients, it is preferable to obtain an extract from the leaves as raw materials.
  • the plant of the Asteraceae plant may be used in a raw state, a frozen state, or a lyophilized state. Preferably, it is in a raw state.
  • the plant body When preparing an extract from a raw or frozen asteraceae plant, the plant body may be first crushed. A mixer, homogenizer, mortar, etc. can be used for crushing plants. The freeze-dried product may be crushed into powder after the freeze-drying operation.
  • a solvent may be used to obtain an extract from a plant.
  • the extraction method using a solvent includes a method of extraction by impregnation in a cooled or heated state at room temperature, a method of extraction using a distillation method such as steam distillation, a compression method of obtaining an extract by pressing, a supercritical fluid or Asia Methods such as extraction using a critical fluid can be suitably used, and these methods can be used alone or in combination of two or more.
  • extraction is performed at room temperature or under heating for 1 to 1 month, preferably 1 to 5 days, using 5 to 100 ml of solvent for crushed raw material lg.
  • the solvent used for the extraction is not particularly limited as long as the active ingredient can be effectively extracted, but is water, an organic solvent miscible with water, such as a lower alcohol such as ethanol, or A mixed solution thereof, or an organic solvent immiscible with water such as ethyl acetate can be mentioned.
  • monohydric alcohols such as methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol and n-octyl alcohol; glycerin, ethylene glycol, ethylene glycol mono A polyhydric alcohol such as methinorethenole, propylene glycolenole, propylene glycolenomonomethinoleatenore, propyleneglycolenomonoethylenoreatenore, triethyleneglycolenole, 1,3-butyleneglycolinole, hexylene glycol or the like Derivatives; Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, and methyl-n-propyl ketone; Esters such as isopropyl acetate; Ethyl ether, isopropyl ether, n-
  • Ethers such as squalene, petrolatum, paraffin wax, paraffin oil; vegetable oils such as olive oil, wheat germ oil, rice oil, sesame oil, mackerel damian nut oil, almond oil, coconut oil; beef fat, pig Examples thereof include animal fats such as fat and whale oil.
  • a polar solvent to which inorganic salts such as phosphate buffered saline are added and a solvent to which a surfactant is added can be used, and there is no particular limitation. Considering safety for use in food and drink, application to the human body including application to the skin, etc., it is particularly preferable to extract with water and / or alcohol! /.
  • the extraction operation may be performed step by step. For example, extraction is performed with an organic solvent that is miscible with water, such as a lower alcohol such as ethanol, the mixture is concentrated with an evaporator, and an organic solvent that is immiscible with water, such as ethyl acetate, and water are added. May be separated into layers.
  • an organic solvent that is miscible with water such as a lower alcohol such as ethanol
  • the mixture is concentrated with an evaporator
  • an organic solvent that is immiscible with water such as ethyl acetate
  • the extract of the Asteraceae plant thus obtained may be used as it is, and may be subjected to a purification treatment such as deodorization and decolorization as long as the effect is not lost. Also extract In order to increase the concentration of the active ingredient therein, the obtained extract can be further subjected to means such as concentration, liquid-liquid distribution, adsorption chromatography, normal phase or reverse phase chromatography.
  • These extracts, purified products or fractions thereof may be dried to solids by removing the solvent from these extracts, and may also be in a form solubilized in a solvent such as alcohol. Can be used in the form of an emulsion.
  • Power rolls are known to be mainly contained in the Asteraceae plants, in addition to Momigasa, Cacana adenostyloides ⁇ Cacalia
  • the activator according to the present invention preferably contains a power roll as an active ingredient.
  • the strength roll concentration in the extract can be measured using HPLC as described in Example 1, for example.
  • a refined product with an increased content of a power roll as an active ingredient or a pure power carol product as an active ingredient is also suitable as an active ingredient of the activator according to the second invention of the present invention.
  • the power roll can be chemically synthesized using talesol methyl ester as a raw material (see Chem. Lett., 1317 (1975)).
  • the power roll obtained by chemical synthesis can also be suitably used as an active ingredient of the activator according to the present invention.
  • An extract of the Asteraceae plant obtained as described above, a refined product with an increased content of power rolls, or a pure product of power rolls can be used as an activator as it is. It is preferable to combine with cosmetics, quasi-drugs, pharmaceuticals, and foods and drinks in the form of a composition.
  • the concentration of the extract of the Asteraceae plant is appropriately selected depending on the degree of absorption, degree of action, product form, frequency of use, etc., and is not particularly limited. It is sufficient to select the blending concentration within a range that does not impair the cell activation effect.
  • the force roll concentration is from 0.001 to 100,000 mg / ml, preferably from 0.00 to 10 ng / ml, more preferably Is 0. l to lng / ml.
  • a third invention of the present invention is [1] a method for producing a plant extract containing a power roll, and a fourth invention of the present invention is [2] a collagen production promoter.
  • the method for producing a plant extract containing a power roll according to the third invention of the present invention comprises a step of obtaining a secondary extract from a plant extract containing a power carol using a mixture of water and a hydrophilic organic solvent.
  • a plant extract containing a power roll used in the above process is acceptable. It is only necessary that the chlorophyll content of the secondary extract obtained after the implementation of the above process is reduced as compared with the chlorophyll content contained in the extract.
  • the above “step for obtaining a secondary extract from a plant extract containing a power roll using a mixture of water and a hydrophilic organic solvent” is hereinafter referred to as “step 1”.
  • the power roll is known to be the main component of the extract of Momijigasa and has a structure represented by the formula (I).
  • Momijigasa is a plant belonging to the genus Komorisou, and is widely distributed in Japan and eaten as a wild vegetable. It is known that power rolls are also contained in asteraceae plants other than Momigasa, for example, Cacalia
  • the "plant extract containing a power roll" used in step 1 is a plant extract, As long as it contains a tool. Specifically, the primary extract from the plant containing a power roll is mentioned, for example. The primary extract from plants usually contains a large amount of chlorophyll, so it can be reduced to chlorophyll content by applying it to Step 1, and the secondary extract with high power roll content. Can be obtained.
  • the secondary extract obtained by subjecting the primary extract from the plant to Step 1 may be subjected to Step 1 again as a "plant extract containing a force carol"! /.
  • the second secondary extract thus obtained has a lower chlorophyll content than the first secondary extract.
  • the target value of the chlorophyll content may be appropriately set according to the purpose of use of the plant extract containing the power roll finally obtained. In plant extracts containing force rolls, it is preferable to reduce the chlorophyll content as much as possible. Most preferably, it is below the detection limit when measured using a known chlorophyll concentration measurement method. Therefore, for example, the target numerical value of the chlorophyll content may be set as the detection limit value.
  • the chlorophyll concentration in the plant extract can be quantified by, for example, dissolving the plant extract in a suitable solvent and measuring the absorbance.
  • a method for obtaining a primary extract from a plant containing a power roll is not particularly limited, and a known method can be appropriately selected and used.
  • plant parts as raw materials may be separated from rhizomes, stems, and leaves that are larger than the whole plant body, and the respective parts may be used as raw materials. Further, a material obtained by appropriately combining the respective parts may be used as a raw material. Since the present inventors have found that there are many active ingredients in roots, stems, and leaves, particularly leaves, when using Momijigasa as a raw material, it is preferable to obtain an extract using leaves as a raw material.
  • the raw material plant may be in a raw state, a frozen state, or a lyophilized state. Preferably, it is in a raw state.
  • the plant body When preparing a primary extract from a raw or frozen plant body, the plant body may be first crushed. A mixer, a homogenizer, a mortar, etc. can be used for crushing a plant body. If freeze-dried, freeze-dry After the operation, the powder may be crushed.
  • Examples of a method for obtaining a primary extract from a plant include a method using a solvent.
  • the extraction method using a solvent includes a method of extraction by impregnation in a cooled or heated state at room temperature, a method of extraction using a distillation method such as steam distillation, a compression method of obtaining an extract by pressing, a supercritical fluid or Extraction methods using subcritical fluids can be suitably used, and these methods can be used alone or in combination of two or more.
  • a distillation method such as steam distillation
  • a compression method of obtaining an extract by pressing a supercritical fluid or Extraction methods using subcritical fluids
  • these methods can be used alone or in combination of two or more.
  • 5 to 100 ml of solvent is used for the crushed raw material lg, and extraction is performed at room temperature or under heating for 1 hour to 1 force for 1 month to 1 month, preferably 1 to 5 days.
  • the solvent used in the extraction is not particularly limited as long as it is a solvent from which the power roll, which is an active ingredient, can be effectively extracted, but water or water such as ethanol or a lower alcohol. Examples thereof include organic solvents that are miscible, or mixtures thereof, or organic solvents that are immiscible with water, such as ethyl acetate.
  • monohydric alcohols such as methanol, isopropanol, isobutanol monole, n-hexanol, methenoleaminoleanoreconole, 2-ethylbutanol, n-octyl alcohol; glycerin, ethylene glycol , Ethylene glycol monomethino ethenore, propylene glycol nore, propylene glycol eno mono ethino enore, propylene glycol eno mono chineno ethenore, triethylene glycol nore, 1,3 butylene glycol mononore, hexylene glycol, etc.
  • monohydric alcohols such as methanol, isopropanol, isobutanol monole, n-hexanol, methenoleaminoleanoreconole, 2-ethylbutanol, n-octyl alcohol
  • Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl n propyl ketone; Esters such as isopropyl acetate; Ethyl ether, Isopropyl ether, n Butyl ether Ethers such as oil; hydrocarbons such as squalene, petrolatum, paraffin wax, paraffin oil; vegetable oils such as olive oil, wheat germ oil, rice oil, sesame oil, mackerel damian nut oil, almond oil, coconut oil; Examples include animal fats such as beef tallow, pork tallow and whale oil.
  • a polar solvent to which inorganic salts such as phosphate buffered saline are added and a solvent to which a surfactant is added can be used without any particular limitation. Considering safety for use in food and drink, application to the human body including application to the skin, etc., it is particularly preferable to extract with water and / or alcohol! /.
  • the extraction operation may be performed step by step! /.
  • extraction is performed with an organic solvent that is miscible with water, such as a lower alcohol such as ethanol, and the mixture is concentrated with an evaporator or the like.
  • An organic solvent immiscible with water, such as oxyethyl, and water may be added and separated into an organic solvent layer and an aqueous layer.
  • the primary extract thus obtained is preferably concentrated to dryness by removing the solvent.
  • step 1 Next, step 1 will be described.
  • Step 1 for example, a secondary extract is obtained using a mixture of water and a hydrophilic organic solvent with respect to a primary extract from a plant containing a power roll obtained as described above.
  • the plant extract containing the power roll used in step 1 is not limited to the primary extract from the plant, but also includes the secondary extract that has already been subjected to the extraction process in step 1. Is preferred.
  • hydrophilic organic solvent such as methanol, ethanol, propyl alcohol, I isopropyl alcohol, lower alcohols having 1 to 5 carbon atoms in butanol; acetone, lower aliphatic ketones such as methylcarbamoyl Ruechiruketon; 1, 3
  • examples include polyhydric alcohols having 2 to 5 carbon atoms such as butylene glycol, propylene glycol, and glycerin. These may be used alone or in combination of two or more. Good.
  • the hydrophilic organic solvent used for the secondary extraction is particularly considered ethanol, acetone, isopropyl alcohol, propylene glycol, It is preferable to use butylene glycol and butanol.
  • Moisture content, ie chlorophyll content in the plant extract containing the power roll that the chlorophyll content in the secondary extract was subjected to step 1 The water content of the mixture of water and hydrophilic organic solvent, which will be further reduced, varies depending on the type of hydrophilic organic solvent, the type of raw material plant, the part of the raw material plant used, etc. It is preferable to confirm it.
  • hydrous ethanol having an ethanol content of 45% or more, more preferably hydrous ethanol having an ethanol content of 50% to 70%, more preferably Hydrous ethanol with an ethanol content of 55% to 65%.
  • the first step is, for example, adding water and It can be carried out by adding a mixture of hydrophilic organic solvents and allowing to stand, and then collecting the supernatant.
  • Step 1 By performing Step 1, it is possible to obtain a plant extract having a high content of power rolls and a low content of chlorophyll at a low cost in terms of efficiency. Further, by repeating Step 1, a plant extract containing a power roll containing almost no chlorophyll can be obtained.
  • the chlorophyll concentration in the plant extract can be quantified by, for example, dissolving the plant extract in a suitable solvent and measuring the absorbance.
  • the obtained extract is further concentrated and liquid-liquid distributed as desired. It can also be subjected to means such as adsorption chromatography, normal phase or reverse phase chromatography.
  • a method for producing a plant extract containing a power roll according to the third invention of the present invention comprises a step 1 (secondary extraction from a plant extract containing a power roll using a mixture of water and a hydrophilic organic solvent.
  • a step 1 secondary extraction from a plant extract containing a power roll using a mixture of water and a hydrophilic organic solvent.
  • contaminants that are more hydrophilic than the power roll are removed from the plant extract containing the power roll using water or a mixture of water and a hydrophilic organic solvent. It is preferable to include a step of leaving. By adding this step, it is possible to obtain a plant extract containing a power roll in which both the chlorophyll content and the highly hydrophilic contaminant content are low.
  • Step 2 the above-mentioned “step of removing contaminants having a higher hydrophilicity than the power color from water or a mixture of water and a hydrophilic organic solvent from the plant extract containing the power roll”
  • Step 2 the above-mentioned “step of removing contaminants having a higher hydrophilicity than the power color from water or a mixture of water and a hydrophilic organic solvent from the plant extract containing the power roll”.
  • the “plant extract containing a power roll” used in Step 2 is a temporary extract obtained from a plant containing a power carol described above, or a secondary extraction that has already been subjected to the extraction process of Step 1. And an extract obtained by repeatedly performing the extraction process in Step 1.
  • the “plant extract containing a power roll” to be used in step 2 is a concentrated dry product from which the solvent has been removed.
  • Step 2 may be provided before Step 1 or after Step 1.
  • step 2 may be provided between the previous step 1 and the subsequent step 1.
  • the hydrophilic organic solvent suitably used in Step 2 is the same as that exemplified in the description of Step 1.
  • the preferred water content in the mixture of water and hydrophilic organic solvent that is, the water content of the mixture of water and hydrophilic organic solvent that can efficiently remove impurities that are more hydrophilic than the power roll is Therefore, it is preferable to preliminarily check the optimal water content each time.
  • hydrophilic solvent when ethanol is used as the hydrophilic solvent, it is preferable to use hydrous ethanol having an ethanol content of 40% or less, more preferably hydrous ethanol having an ethanol content of 10% to 30%, and even more preferably. It is hydrous ethanol with an ethanol content of 15% to 25%.
  • water containing no hydrophilic organic solvent can be used as the extraction solvent.
  • the second step for example, water or a mixture of water and a hydrophilic organic solvent is added to a plant extract containing a power roll used in this step, and the mixture is allowed to stand, and then the precipitate is recovered. Can be implemented. The removal of highly hydrophilic impurities from the power roll can be confirmed by the decrease in the weight of the extract.
  • the plant extract containing the power roll obtained through the first step or the plant extract containing the power roll obtained through the first step and the second step removes the solvent.
  • it can be made into a dried product, and further, it can be used in a form solubilized in a solvent such as alcohol or an emulsion.
  • the method for producing a plant extract containing a power roll according to the third invention of the present invention is applicable to a power plant that can be applied to any plant as long as it contains a power carol. Is preferred.
  • Asteraceae plants there are Arctoseca, Akinokirinso, Akinonogeshi, Azami,
  • Chrysanthemum genus Hydrobana genus, Greater thistle genus, Felicia genus, Fuchsia poppo genus, Fuchsia genus, Fuchus genus, Futana genus, Futama dandelion genus, Francis genus, Buddlesia genus, Ragweed genus, Helenium genus, Safflower genus Porimunia genus, Mamekamitsure
  • Misumigusa Mizuhimabori, Miyamamena, Muchasomoghi, Mugiwaragiku, Metakarakoma, Menamomi, Melanpodium, Mokuyungiku, Mokubiyakkou, Momijihaguma, Yakuno-gama, Amanagambipha Genus, wildflower genus, yuryopus genus, genus genus, mugwort genus, mugwort genus, dandelion genus, but it is not particularly limited to the family Asteraceae as long as it contains a power roll. Is preferred.
  • bats are bats, maples, powers, tamabuki, inuduna, izkanikomori, okanakumori, taimingasa, kushikoumoriso, tebacomomijigasa, nishinoyamataiminga, It is done.
  • Momijigasa which is preferred by edible plants, is suitable. The best mode for carrying out the fourth invention of the present invention will be described.
  • the collagen production promoter according to the fourth invention of the present invention only needs to contain a force roll as an active ingredient.
  • the power roll can be obtained as a plant extract containing the power roll by the production method according to the third aspect of the present invention.
  • a refined product with an increased content of a power roll as an active ingredient, or a pure power carol product as an active ingredient is also used as an active ingredient of the collagen production promoter according to the fourth invention of the present invention. It can be used suitably.
  • the power roll can be chemically synthesized using talesol methyl ester as a raw material.
  • a force roll obtained by chemical synthesis can also be suitably used as an active ingredient of the collagen production promoter according to the fourth invention of the present invention.
  • the plant extract containing a powerful roll by the production method according to the third aspect of the present invention described above can be used as a collagen production promoter as it is.
  • the concentration of the plant extract containing force carol is appropriately selected depending on the degree of absorption, degree of action, product form, frequency of use, etc., and is not particularly limited. It is sufficient to select the blending concentration within the range that does not impair the collagen production promoting action.
  • the force roll concentration is 0.001 to 100,000 ng / ml, preferably 0.01 to 10 ng / ml, more preferably 0. 01—Use 1 ng / ml.
  • the activator according to the second invention of the present invention and the collagen production promoter according to the fourth invention of the present invention are formulated into cosmetics, quasi-drugs, pharmaceuticals, and foods and drinks. It is preferable to carry it out in the form. The following forms will be described.
  • the dosage form is not limited, and ampules, capsules, powders, granules, pills, tablets, solids, liquids, gels, bubbles, emulsions, creams, ointments, sheets, mousses, bath preparations, etc. thing Can do.
  • cosmetics, quasi-drugs, and pharmaceuticals include, for example, internal and external pharmaceutical preparations, skin lotions, emulsions, creams, ointments, lotions, oils, packs, and other basic cosmetics, face wash, Skin cleansers, shampoos, rinses, hair treatments, hair creams, pomades, hair sprays, hair styling agents, permanents, hair nicks, hair dyes, hair restorations such as hair conditioners, cosmetics, foundations, white powder, funny hair, lipstick, Makeup cosmetics such as scarlet, eye shadow, eyeliner, mascara, eyebrows, eyelashes, cosmetics for finishing such as nail polish, perfumes, bath preparations, other toothpastes, mouth fresheners and mouthwashes Liquid odor / deodorant, hygiene products, sanitary cotton, wet tissue, etc.
  • examples of food and drink include soft drinks, carbonated drinks, nutrition drinks, fruit drinks, lactic acid drinks, ice cream, ice sherbet, power, frozen ice confectionery such as soba, udon , Harusame, Gyoza skin, Pomegranate skin, Chinese rice cake, instant rice cake, etc., rice cake, candy, gum, chocolate, tablet confectionery, snack confectionery, biscuit, jelly, jam, cream, baked confectionery, bread, etc.
  • the activator according to the second invention of the present invention or the collagen production promoter according to the fourth invention of the present invention can be suitably applied to humans. As long as it is applicable to animals other than humans.
  • the activator according to the second invention of the present invention or the collagen production promoter according to the fourth invention of the present invention is added to the asteraceae plant extract, which is an active ingredient, as required.
  • the effects of the second or fourth invention are not impaired, cosmetics, quasi drugs and pharmaceuticals
  • the ingredients and additives used in food and drink can be used in combination.
  • bases and additives usually used in cosmetics as shown below, such as fats and oils, waxes, mineral oils, fatty acids, alcohols, esters, metal soap, gum Quality and water-soluble polymer compounds, surfactants, vitamins, amino acids, whitening agents, moisturizers, microbial culture metabolites, hydroxy acids, inorganic pigments, UV absorbers, astringents, antibacterial agents, bactericides, disinfectants, It can be used in combination with hair preparations, fragrances, pigments / colorants, sweeteners, nutrition enhancers, hair restorers, animal and plant extracts, antioxidants, anti-inflammatory agents, and the like.
  • apogad oil apogad oil, almond oil, wikiyo oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, kaka-age ⁇ , power mitsule oil, power lot oil, cucumber Oil, beef tallow, beef tallow fatty acid, cucumber nut oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm Oil, palm kernel oil, owl, coconut oil, beef tallow, lard, hydrogenated oil, hydrogenated castor oil.
  • waxes include beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelillaro, montan wax, shellac wax and the like.
  • mineral oils examples include liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, polyethylene powder, squalene, squalane, and pristane.
  • fatty acids natural fatty acids such as lauric acid, myristic acid, normitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, and isononanoic acid
  • synthetic fatty acids such as caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.
  • the alcohols include natural alcohols such as ethanol, isopropanol, lauryl alcohol, cetanol, stearinoreanoleconore, oleinoleanoreconole, lanolinanoreconole, cholesterol, phytosterol, etc.
  • Synthetic alcohols such as xyldecanol, isostearyl alcohol, 2-octyldodecanol, ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol Noremonochinenoatenore, ethyleneglycolenobutinorenoatenore, diethyleneglycol noremonomethinoreatenore, diethyleneglycolenolemonotinoreatenore, polyethyleneglycolinole, propyleneoxide, propyleneglycolole, polypropyleneglycol 1, 3-butyleneglycolone, glycerin, notinorenoreconole, pentaerythritole, sonorebitonore, mannitol, glucose, sucrose and other polyhydric alcohols.
  • esters isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl octanoate Nole, cetyl lactate, myristyl lactate, jetyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.
  • Examples of the metal soap include aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.
  • gums and water-soluble polymer compounds include gum arabic, benzoin rubber, dammar gum, guayata fat, Irish moss, kala gum, tragacanth gum, kilob gum, quinseed, agar, casein, dextrin, gelatin, pectin, Starch, carrageen, chitosan salt, sulfated chitin, phosphorylated chitin, alginic acid and its salt, hyaluronic acid and its salt, chondroitin sulfate, heparin, ethyl cellulose, methylcellulose
  • Rosenorelose crystalline senorelose, polyvinylenorenoleconole, polyvinino methinoreatenore, polybulol pyrrolidone, polybull metaaterylate, polyacrylic acid salt, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or cross-linking thereof Polymers, carboxybule polymers, polyethyleneimine and the like can be mentioned.
  • an anionic surfactant (carboxylate, sulfonate, sulfate ester salt, phosphate ester salt), a cationic surfactant (ammine salt, quaternary ammonia) Um salt), amphoteric surfactant (carboxylic acid type amphoteric surfactant, sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant), nonionic surfactant Agents (ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other interfaces Activating agents (natural surfactants, derivatives of protein hydrolysates, polymeric surfactants, surfactants containing titanium'-carbon, fluorocarbon surfactants, etc.).
  • vitamin A1 retinol
  • vitamin A2 dehydroretinal
  • vitamin A2 carotene
  • lycopene provitamin A
  • vitamin B group thiamine hydrochloride
  • thiamine sulfate Vitamin B1
  • riboflavin riboflavin
  • Vitamin B2 Vitamin B2
  • pyridoxine vitamin B6
  • cyanocobalamin vitamin B12
  • folic acid nicotinic acid
  • pantothenic acid biotin
  • biotin choline
  • inositol vitamin C group
  • vitamin D group In ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotachysterol, vitamin E group, tocopherol and its derivatives, ubiquinones, vitamin K group, futonadione (vitamin K1) Menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), and the like.
  • amino acids include norine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, and aspartic acid.
  • amino acid derivatives such as sulphates, phosphates, nitrates, citrates, pyrrolidone carboxylic acids, etc., and gnoretamic acid, hydroxylysine, anoleginine, norenitine and histidine.
  • whitening agents include ascorbic acid or a derivative thereof, io, placental hydrolyzate, ellagic acid or a derivative thereof, kojic acid or a derivative thereof, darcosamine or a derivative thereof, arbutin or a derivative thereof, hydroxykehiic acid or a derivative thereof Derivatives such as glutathione, A / Leni force extract, gonon extract, sohakuhi extract, psycho extract, boufeque kiss, mynentake mycelium culture or extract thereof, linden extract, peach leaf extract, Examples include AGE extract, KUJIN extract, juju extract, toki extract, rye quinin extract, brilliant leaf kiss, dai sai extract, bot pi extract, cucumber bean extract, marronnier extract, virgin togiri extract, and oil-soluble licorice extract.
  • hyaluronic acid polyglutamic acid, serine, glycine, threonine, alanine, collagen, hydrokeratin collagen, hydronectin, fibronectin, keratin, elastin, royal jelly, chondroitin sulfate heparin, Glyce mouth phospholipid, Glyce mouth phospholipid, Sphingo phospholipid, Sphingo glycolipid, Linoleic acid or its esters, Eicosapentaenoic acid or its esters, Pectin, Bifidobacterium fermented product, Lactic acid fermented product, Yeast extract, Ganoderma Mycelium culture or extract thereof, wheat germ oil, avogad oil, rice germ oil, jojoba oil, soybean phospholipid, ⁇ — oryzanol, belode oyster kiss, yoku yun extract, di sai extract, taiso extract, force is
  • extracts or extracts of animals, plants, or herbal medicines include Azenak (Asenyaku), Ashitaba, Acerola, Anolethea, Arni, Avocado, Amatya (Amacha), Aloe, Aloe Vera, Nettle, Ichiyo ( Ginkgo biloba, Ginkgo), Wikiyo (Yuka), Ukon (Usukin), Uspasai Shin (Spicy), Ume (Plum), Vulture, Ganoderma, Neubara (Yutoshi), Hikikoshi (Extended Life Grass), Ogi (Yellow) , Koganebana (Ogon), Chestnut cherry (cherry bark), Kihada (Yellow), Oren (Yellow), Ginseng (Ginseng), Otogirisou (Little Cut Grass), Odoricosou, Dutch Garlic, Orange, Itohimehagi (Distance), Ubbodasa Summer hay), Tsuru
  • microbial culture metabolites include yeast extract, zinc-containing yeast extract, germanium-containing yeast extract, selenium-containing yeast extract, magnesium-containing yeast extract, rice fermentation extract, Euglena extract, and lactic acid fermented milk powder.
  • examples of ⁇ -hydroxy acids include glyconolic acid, citrate, malic acid, tartaric acid, and lactic acid.
  • anhydrous caustic acid magnesium silicate, talc, kaolin, bentonite, my strength, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate
  • magnesium carbonate yellow iron oxide, red iron oxide, black iron oxide, gundiio, chromium oxide, chromium hydroxide, carbon black, calamine and the like.
  • an ultraviolet absorber ⁇ -aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative
  • examples include camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin 6 derivatives, oxybenzone, benzophenone, guaiazurene, shikonin, baicalin, noikalein, and berberine.
  • astringents include lactic acid, tartaric acid, succinic acid, succinic acid, allantoin, lead chloride, zinc sulfate, zinc oxide, calamine, ⁇ -phenol sulfonate zinc, potassium aluminum sulfate, resorcin chloride, secondary chloride Examples thereof include iron and tannic acid.
  • antioxidants include ascorbic acid and its salts, stearic acid ester, tocopherol and its ester derivatives, nordihydroguasertenic acid, butylhydroxytoluene ( ⁇ ), butylhydroxydisole ( ⁇ ) , Parahydroxyanisole, propyl gallate, sesamol, sesamorin, gossypol and the like.
  • anti-inflammatory agents include ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-forcenfunole, hydrocortisone, guaiazulene, camazulene, maleic acid chloro
  • anti-inflammatory agents include ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-forcenfunole, hydrocortisone, guaiazulene, camazulene, maleic acid chloro
  • lucerilamine glycyrrhizic acid and its salt
  • glycyrrhetinic acid and its salt and the like.
  • disinfectants include atalinol, io, benzalkonium chloride, benzethonium chloride, methyl rosaniline chloride, cresol monole, calcium dalconate, chlorhexidine dalconate, sulfamine, mercurochrome, ratatoferrin or its addition. moisture Examples include scraps.
  • a hair preparation selenium disulfide, alkylisoquinolinium bromide, zinc pilichin, bifuenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water
  • examples include potassium bromate, sodium bromate, and thiodaricholic acid.
  • perfumes natural animal perfumes such as Jiakou, Civet, Castrium, Ambergris, Anise Essential Oil, Angri Essential Oil, Iran Essential Oil, Iris Essential Oil, Wikiyo Essential Oil, Orange Essential Oil, Kananga Essential Oil, Power Laue Essential Oil , Cardamom essential oil, guayata wood essential oil, cumin essential oil, black letter essential oil, key skin essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil , Spearmint essential oil, Western heart force essential oil, Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, batile lily essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, Sandalwood essential oil, Petite
  • red cabbage dye red rice dye, akane dye, anato dye, squid ink dye, turmeric dye, chenju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, Corn pigment, onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigo mulberry pigment, purple imo pigment, purple potato pigment, lac pigment, rutin, etc. Is mentioned.
  • sweetener examples include sugar, sweet tea, fructose, arabinose, galactose, xylose, mannose, maltose, honey, glucose, miraculin, monelin and the like.
  • examples of the nutrient fortifier include shell calcined calcium, cyanobactamine, yeast, wheat germ, soybean germ, egg yolk powder, hemicellulose, heme iron and the like.
  • the activator according to the second invention of the present invention or the collagen production promoter according to the fourth invention of the present invention is one that is suitably applied to humans. As far as possible, it can also be applied to non-human animals.
  • the activator according to the second invention of the present invention or the collagen production promoter according to the fourth invention of the present invention is not particularly limited, but a nonionic surfactant or lower alcohol is not particularly limited. It can be used by dissolving in alcohol, polyhydric alcohol, or natural oils such as olive oil, squalane and fatty acids.
  • nonionic surfactant examples include sorbitan fatty acid esters (for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan).
  • sorbitan fatty acid esters for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan).
  • glycerin polyglycerin fatty acids eg mono cottonseed oil fatty acid glycerin, Glyceryl monoellate, glyceryl sesquioleate
  • hydrophilic hydrophilic nonionic surfactant examples include ⁇ -sorbitan fatty acid esters (for example, ⁇ -sorbitan monooleate, ⁇ -sorbitan monostearate, ⁇ -sorbitan monoo).
  • ⁇ sorbitan tetraoleate, etc .
  • ⁇ sorbite fatty acid esters eg, ⁇ —sorbite monolaurate, ⁇ —sorbite monooleate, ⁇ —sorbitol pentaoleate, ⁇ —sorbite monostearate, etc.
  • ⁇ -glycerin fatty acid esters eg, ⁇ -glycerol monostearate, ⁇ -glycerol monoisostearate, ⁇ -glycerol triisostearate, etc.
  • -fatty acid esters eg, ⁇ —Disteare , POE monodiolate, ethylene glycol distearate, etc .
  • POE alkynole ethers eg, POE lauryl ether, POE oleyl ether, POE-stearyl ether, POE behenyl ether, POE-2-Otachidodecyl ether, POE cholest
  • Tetra POP ethylene diamine condensates (eg, Tetronic etc.); POE castor oil hardened castor oil derivatives (eg, POE castor) Oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE Castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, POE hydrogenated castor oil maleic acid, etc.); POE beeswax 'lanolin derivatives (eg POE sorbite beeswax etc.); Coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE propylene glycol fatty acid ester; POE-alkylamine; POE fatty acid amide; sucrose fatty acid ester; alkylethoxydimethylamine oxide; trioleyl phosphoric acid, etc. Can be mentioned.
  • POE castor oil hardened castor oil derivatives
  • Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol, and the like.
  • polyhydric alcohol examples include divalent alcohols (for example, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycolol, tetramethylene glycolol, 2, 3 Butylene glycolanol, pentamethylene glycolanol, 2 butene 1,4 dianol, hexylene glycolanol, octylene glycol, etc .; trivalent alcohol (eg, glycerin, trimethylolpropane, etc.); tetravalent alcohol (eg, 1, 2, 6 hexanetriol, etc.
  • divalent alcohols for example, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycolol, tetramethylene glycolol, 2, 3 Butylene glycolanol, pentamethylene glycolanol, 2 butene 1,4 dianol, hexylene glycolanol,
  • pentaerythritol, etc. pentavalent alcohol
  • pentavalent alcohol eg, xylitol, etc.
  • hexavalent alcohol eg, sonorebitanol, mannitol, etc.
  • polyhydric alcohol polymer eg, diethylene glycol, diethylene glycol, etc.
  • divalent Alcohol alkyl ethers for example, ethylene glycol monomethyl ether, ethylene glycol monoethyl enoate ethere, ethylene glyco mono mono butyl mono ether, ethylene glycol mono mono mono eno mono ether, Tenoré, Ethyleneglycolenomono 2-Methylenohexenoleethenore, Ethylene
  • oils avocado oil, olive oil, sesame oil, camellia oil, evening primrose oil, turtle oil, madame demian nut oil, corn oil, mink oil, rapeseed oil, egg yolk oil, persic oil, oat germ oil , Southern power oil, castor oil, Amani oil, safflower oil, cottonseed oil, Eno oil, soybean oil, peanut oil, tea seed oil, cocoa oil, rice bran oil, kiri oil, jojoba oil, cocoa butter, coconut oil, Animal and vegetable oils such as horse oil, palm oil, palm kernel oil, beef tallow, sheep fat, pork tallow, lanolin, whale wax, beeswax, carnauba roux, moclaw, candelilla roux, squalane, and hardened oils thereof.
  • Examples of higher fatty acids include lauric acid, myristic acid, normitic acid, oleic acid, linoleic acid, linolenic acid, stearic acid, behenic acid, 12-hydroxystearic acid, isostearic acid, undecinic acid, and toric acid. Eicosapentaenoic acid and docosahexaenoic acid.
  • Examples of the higher alcohol include laurino enorecol, cetyl alcohol, stearino enore monole, behenino enore enore, myristino enore: 3-nore, rei leino enore enore, ceto stearino enorenore, Jojobano Reconole, Lanolinano Reconole, Notino Reano Renore, 2-Desino Rete Tethecinore, Cholesterol Nore, Phytosterol Nore, Isostearinore Alcohol, etc.
  • Synthetic esters include, for example, cetyl octanoate, octyldodecyl myristate, isopropyl myristate, myristyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, decyl orenate, dimethyl octanoate, cetyl lactate, Examples include myristyl lactate.
  • the silicone include chain polysiloxanes such as dimethyl polysiloxane and methinorefinole polysiloxane, cyclic polysiloxanes such as decamethylenocyclopolysiloxane, and three-dimensional network structures such as silicone resins.
  • SOD Superoxide dismutase analysis kit WST (manufactured by Dojindo Molecular Technologies) was used to measure the superoxide elimination ability of the power roll. A specific method is described below. For the solutions not specifically described in the following method, those provided in the above measurement kit or those prepared according to the method of using the kit were used.
  • the power roll showed a superoxide elimination rate of 28% at a final concentration of ImM.
  • astaxanthin and vitamin E used as comparative products were precipitated in the reaction solution at the same concentration, and thus could not be evaluated. Superoxide scavenging action was not observed even at concentrations below that level.
  • the reagent solution mixed with 100 1 was preincubated at 37 ° C.
  • ImM hydrogen peroxide 100 1 and power roll solution 100 1 of each concentration were mixed, incubated at 37 ° C for 20 minutes, immediately mixed with the above reagent solution, and reacted at 37 ° C for 5 minutes.
  • Absorbance at 555 nm was measured with a microplate reader. As a control, the following conditions were also measured in the same manner.
  • the hydrogen peroxide scavenging rate of the sample was obtained by calculating the formula 100_ (S—B2) / B1 ⁇ 100.
  • S is A with hydrogen peroxide added 'sample added
  • Bl (Blank 1) is hydrogenated with hydrogen peroxide' A with MilliQ water added
  • B2 (Blank 2) is not added with hydrogen peroxide (Instead, MilliQ water added) 'Shows A for sample addition.
  • Astaxanthin was used as a substance to be compared. The results are shown in Figure 1.
  • the power roll showed a high hydrogen peroxide scavenging rate compared to wastaxanthin.
  • Vitamin E used as a comparative product was precipitated in the reaction solution at the same concentration, so it could not be evaluated, and no superoxide scavenging action was observed even at concentrations below that.
  • the singlet oxygen scavenging rate of the sample was obtained by calculating the formula 100_ (S—B2) / B1 ⁇ 100.
  • S is A with light irradiation and sample addition
  • Bl is A with light irradiation 'MilliQ water addition
  • B2 is A with light non-irradiation sample addition. Show.
  • Astaxanthin and vitamin E were used as comparative substances. The result is shown in figure 2. It was shown that the power roll has a higher singlet oxygen scavenging ability than vitamin E, although the scavenging rate is lower than that of wastaxanthin, which is known as a singlet oxygen scavenger.
  • Example 1 The strength roll was dissolved in butylene glycol at a concentration of 0.5% and allowed to stand at room temperature 'light place, room temperature' place, 4 ° C. Analysis was performed under the HPLC conditions described. The results are shown in Figure 3. It was found that the power roll showed high stability under any condition, and the active oxygen scavenger of the present invention maintained its effect for a long time.
  • a cosmetic liquid having the following composition was produced by a conventional method.
  • a serum containing no force roll was also produced by a conventional method.
  • Power roll (power roll concentration 0.01%) 1.0
  • Total amount of purified water is 100
  • An emulsion having the composition shown below was produced by a conventional method. Power roll as a control No emulsions were prepared by conventional methods.
  • Power roll (power roll concentration 0.01%) 1.0
  • Total amount of purified water is 100
  • a cream having the following composition was produced by a conventional method.
  • a cream containing no force roll was also produced by a conventional method.
  • Power roll (power roll concentration 0.01%) 1.0
  • Example 10 Preparation of maple extract
  • 250 g of Momijigasa was lyophilized and extracted with 500 ml of a mixture of methylene chloride and methanol 1: 1.
  • the concentration of the force roll was measured by HPLC analysis under the following conditions.
  • Normal human skin fibroblasts were cultured by a conventional method using a normal human skin fibroblast total kit (CA106K05, manufacturer: Cell Applications Inc. USA, importer / distributor: Toyobo Co., Ltd.).
  • an ethanol group (final concentration 0.5%) was provided.
  • an SDS-added group (final concentration: 0.1%) was provided to confirm that cell growth was inhibited by cytotoxic substances.
  • the medium was replaced with a medium containing 100 ⁇ g / mL of 3- (4,5-dimethyl-2-thiazolyl) -2,5-diphenyltetrazolium bromide (MTT) and cultured for 3 hours.
  • Formazan produced by ring-opening was extracted with 2-propanol and the absorbance at 550 nm was measured with a microplate reader. At the same time, the absorbance at 650 nm was measured as turbidity, and the cell activation effect was evaluated by the difference between the two measured values.
  • the maple extract has an excellent cell activation effect, and by applying the maple extract to the skin, it exhibits an extremely excellent anti-aging effect, It was suggested that skin wrinkles and sagging caused by aging, UV exposure, etc. can be effectively improved.
  • a cosmetic liquid having the following composition was produced by a conventional method.
  • a serum containing no Momijigasa extract was also produced by a conventional method.
  • Total amount of purified water is 100
  • An emulsion having the composition shown below was produced by a conventional method.
  • an emulsion containing no Momijigasa extract was also produced by a conventional method.
  • Total amount of purified water is 100
  • a cream having the following composition was produced by a conventional method.
  • a cream containing no Momijigasa extract was also produced by a conventional method.
  • Acid polyester 38.0 sodium edetate 0.03
  • Total amount of purified water is 100
  • a use test was conducted using the cream produced in Example 14 above.
  • the evaluation items were self-evaluation of the improvement effect on spots and kusumi.
  • a cream containing no Momijigasa extract was used blind.
  • five panelists aged 25 to 50 years used it for 1 month, and evaluated before and after use in three stages: improved, slightly improved, and no change.
  • the examples of the present invention were more effective in improving wrinkles and rough skin than the conventional comparative examples.
  • Example 15 Preparation of tartorol extract using ethanol with different water contents
  • 2 kg of Momijigasa leaves were lyophilized and stirred with a mixer to obtain 212 g of powder.
  • 4 L of ethanol was added to this powder, stirred for 12 hours, filtered to remove insoluble matters, and concentrated to obtain 16 g of a green primary extract.
  • 8 ml each of water or ethanol containing 10% to 90% water was added to 0. lg of this extract, and after sonication, the mixture was allowed to stand at 5 ° C. Centrifugation was performed at 7000 rpm for 15 minutes to separate the supernatant and the precipitate. The supernatant was used as it was, and the precipitate was dissolved in 8 ml of dimethylformamide to prepare a sample for measuring force rolls.
  • the concentration of the power roll in the sample was measured by HPLC analysis under the following conditions.
  • Fig. 5 shows the results of the power roll concentration in the sediment, and Fig. 5 shows the results of the power roll concentration in the supernatant.
  • Example 16 Production of plant extract containing force roll using 60% ethanol and 20% ethanol
  • the force roll concentration was measured by the method described in Example 15.
  • the plant extract (sample) containing force carol was the plant extract produced in Example 16.
  • the evaluation was performed according to the following procedure.
  • Normal human dermal fibroblasts were cultured by a conventional method using a normal human dermal fibroblast total kit (CA106K05, manufacturer: Cell Applications Inc. USA, import sales company: Toyobo Co., Ltd.).
  • the collagen production acceleration rate was determined by measuring a standard product with the above-mentioned ELISA kit, creating a calibration curve from the results, and determining the collagen production amount when the sample was added and the collagen production amount when no sample was added from the calibration curve.
  • the results are shown in FIG.
  • the horizontal axis represents the force roll concentration in the extract.
  • the collagen production activity (collagen production promoting effect) of human skin is more remarkable than that of the blank (ethanol) in the medium supplemented with the extract of plant (Momigasa) containing a powerful roll. It was recognized that it would increase. From this result, by applying a plant extract containing a power roll, the decline of fibroblasts with aging can be reduced, collagen production can be promoted, and the amount of collagen can be maintained. As a result, it is possible to effectively improve skin wrinkles and sagging caused by aging and exposure to ultraviolet rays.
  • the first invention of the present invention it is possible to provide an excellent active oxygen scavenger such as a plant-derived radical scavenging action and a lipid peroxidation inhibiting action.
  • the first invention of the present invention identifies an active ingredient of the active oxygen scavenging activity of a plant extract. By obtaining it as a more purified substance, it is possible to obtain a safer and more stable physiological effect. It is intended to be widely used as an active substance in cosmetics, functional foods, pharmaceuticals, etc.
  • the active oxygen scavenger of the first invention of the present invention is strong in a small amount! /, And has an active oxygen scavenging effect.
  • the active oxygen scavenger is used for foods and drinks, pharmaceuticals, cosmetics, whitening agents, fertilizers, feeds and the like. By using it as an external preparation for skin, etc., it is possible to obtain an antioxidative effect, in particular, an excellent antioxidative effect such as an effect of improving the storage stability of the product, and various disease preventive effects and antioxidant effects. Therefore, it is expected to greatly contribute to the industry.
  • the second invention of the present invention it is expected to have a cell activation action and an anti-aging action excellent in safety including a power roll, and a cosmetic / quasi-drug containing the cell activation and anti-aging ingredient as an active ingredient. It is expected to make a significant contribution to the industry because it can provide (external skin preparations, bath preparations, hair restorers, etc.), pharmaceuticals, and food and drinks.
  • the third invention of the present invention provides a method for efficiently removing chlorophyll from a plant extract containing a power roll, and greatly contributes to the cosmetics industry, pharmaceutical industry, food industry and the like. Touch with force S.
  • the collagen production promoter according to the fourth invention of the present invention is excellent in the effect of promoting collagen production and contains a safe power roll as an active ingredient. Therefore, it has the effect of sufficiently withstanding long-term use, and can greatly contribute to the cosmetics industry, pharmaceutical industry, food industry, and the like.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'objectif de l'invention est de fournir les éléments suivants : un éliminateur d'oxygène actif qui présente une excellente activité d'élimination de l'oxygène actif ; un agent d'activation ou un agent anti-vieillissement qui présente une excellente activité en matière d'activation des cellules et une excellente activité anti-vieillissement, qui peut supporter une longue utilisation de manière satisfaisante et qui se révèle sûr ; et un promoteur de production de collagène qui possède une grande activité favorisant la production du collagène, qui peut supporter une longue activité de manière satisfaisante et qui se révèle sûr. L'objet de l'invention est également un procédé de production d'un extrait végétal présentant une teneur élevée en cacalol, en retirant la chlorophylle d'un extrait végétal produit à partir d'une plante contenant du cacalol. Pour atteindre l'objectif de l'invention, un éliminateur d'oxygène actif, un agent d'activation, un agent anti-vieillissement et un promoteur de production de collagène, contenant chacun du cacalol, sont fournis. Un procédé est également fourni pour produire un extrait végétal contenant du cacalol, caractérisé par la réduction de la teneur en chlorophylle de l'extrait végétal contenant du cacalol par rapport à celui de l'extrait original, en utilisant un mélange composé d'eau et d'un solvant organique hydrophile dans des proportions de mélanges adéquates.
PCT/JP2007/067795 2006-09-29 2007-09-13 Éliminateur d'oxygène actif, agent d'activation et promoteur de la production de collagène comprenant chacun du cacalol WO2008041460A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008517667A JPWO2008041460A1 (ja) 2006-09-29 2007-09-13 カカロールを含む活性酸素消去剤、賦活化剤、及びコラーゲン産生促進剤

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2006-269797 2006-09-29
JP2006269797 2006-09-29
JP2007001683 2007-01-09
JP2007-001683 2007-01-09
JP2007205006 2007-08-07
JP2007-205006 2007-08-07

Publications (1)

Publication Number Publication Date
WO2008041460A1 true WO2008041460A1 (fr) 2008-04-10

Family

ID=39268323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/067795 WO2008041460A1 (fr) 2006-09-29 2007-09-13 Éliminateur d'oxygène actif, agent d'activation et promoteur de la production de collagène comprenant chacun du cacalol

Country Status (2)

Country Link
JP (1) JPWO2008041460A1 (fr)
WO (1) WO2008041460A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008308436A (ja) * 2007-06-14 2008-12-25 Maruzen Pharmaceut Co Ltd 抗酸化剤、抗老化剤、及び抗炎症剤、並びに皮膚化粧料及び美容用飲食品
JP2010059065A (ja) * 2008-09-02 2010-03-18 Asuka Yume:Kk 痩身化粧料
JP2010195726A (ja) * 2009-02-26 2010-09-09 Noevir Co Ltd デルマトポンチン産生促進剤
JP2011213699A (ja) * 2010-04-02 2011-10-27 Kinki Univ デイジー花部から得られるコラーゲン産生促進作用を有する皮膚外用剤
WO2013118887A1 (fr) * 2012-02-09 2013-08-15 国立大学法人秋田大学 Composition de blanchissement ayant des effets d'inhibition de la synthèse de la mélanine et d'inhibition du mitf et agent anticancéreux
CN103431264A (zh) * 2013-07-18 2013-12-11 浙江劲膳美生物科技有限公司 一种特禀体质者食用的特殊膳食
JP2014198683A (ja) * 2013-03-29 2014-10-23 国立大学法人秋田大学 小眼球症関連転写因子抑制剤、メラニン産生抑制剤、化粧品組成物及び抗ガン剤
CN104792909A (zh) * 2015-04-23 2015-07-22 合肥伟海讴斯医药科技有限公司 一种区别道地药材黄山贡菊与伪品七月菊的方法
JP2015196655A (ja) * 2014-03-31 2015-11-09 小林製薬株式会社 ビタミンｂ６含有組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006188436A (ja) * 2004-12-28 2006-07-20 Japan Science & Technology Agency 医用ポリフェノール溶液

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006188436A (ja) * 2004-12-28 2006-07-20 Japan Science & Technology Agency 医用ポリフェノール溶液

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GIROTTI A.W.: "Lipid hydroperoxide generation, turnover, and effector action in biological systems", J. LIPID RES., vol. 39, no. 8, 1998, pages 1529 - 1542, XP003022119 *
INOUYE Y. ET AL.: "Synthesis of cacalol", CHEM. LETT., no. 12, 1975, pages 1317 - 1318, XP003022122 *
KARRER S. ET AL.: "Influence of 5-aminolevulinic acid and red light on collagen metabolism of human dermal fibroblasts", J. INVEST. DERMATOL., vol. 120, no. 2, 2003, pages 325 - 331, XP003022121 *
SHINDO K. ET AL.: "Potent antioxidative activity of cacalol, a sesquiterpene contained in Cacalia delphiniifolia Sleb et Zucc", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 68, no. 6, 2004, pages 1393 - 1394, XP003022118 *
TANAKA H. ET AL.: "The effect of reactive oxygen species on the biosynthesis of collagen and glycosaminoglycans in cultured human dermal fibroblasts", ARCH. DERMATOL. RES., vol. 285, no. 6, 1993, pages 352 - 355, XP003022120 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008308436A (ja) * 2007-06-14 2008-12-25 Maruzen Pharmaceut Co Ltd 抗酸化剤、抗老化剤、及び抗炎症剤、並びに皮膚化粧料及び美容用飲食品
JP2010059065A (ja) * 2008-09-02 2010-03-18 Asuka Yume:Kk 痩身化粧料
JP2010195726A (ja) * 2009-02-26 2010-09-09 Noevir Co Ltd デルマトポンチン産生促進剤
JP2011213699A (ja) * 2010-04-02 2011-10-27 Kinki Univ デイジー花部から得られるコラーゲン産生促進作用を有する皮膚外用剤
WO2013118887A1 (fr) * 2012-02-09 2013-08-15 国立大学法人秋田大学 Composition de blanchissement ayant des effets d'inhibition de la synthèse de la mélanine et d'inhibition du mitf et agent anticancéreux
JP2013163645A (ja) * 2012-02-09 2013-08-22 Akita Univ メラニン抑制及びｍｉｔｆ抑制作用を有する美白用組成物及び抗ガン剤
JP2014198683A (ja) * 2013-03-29 2014-10-23 国立大学法人秋田大学 小眼球症関連転写因子抑制剤、メラニン産生抑制剤、化粧品組成物及び抗ガン剤
CN103431264A (zh) * 2013-07-18 2013-12-11 浙江劲膳美生物科技有限公司 一种特禀体质者食用的特殊膳食
JP2015196655A (ja) * 2014-03-31 2015-11-09 小林製薬株式会社 ビタミンｂ６含有組成物
CN104792909A (zh) * 2015-04-23 2015-07-22 合肥伟海讴斯医药科技有限公司 一种区别道地药材黄山贡菊与伪品七月菊的方法

Also Published As

Publication number Publication date
JPWO2008041460A1 (ja) 2010-02-04

Similar Documents

Publication Publication Date Title
JP3966922B2 (ja) 線維芽細胞増殖促進剤
JP4732854B2 (ja) ペルオキシソーム増殖剤応答性受容体活性化剤
JP4954531B2 (ja) ペルオキシソーム増殖剤応答性受容体活性化剤
JP4205188B2 (ja) メイラード反応阻害剤
JP2007119373A (ja) メイラード反応生成物分解剤およびそれを用いた飲食品
JP4982822B2 (ja) バイオサーファクタントを有効成分とする賦活化剤
WO2008041460A1 (fr) Éliminateur d'oxygène actif, agent d'activation et promoteur de la production de collagène comprenant chacun du cacalol
JP4931356B2 (ja) グルタミン酸デカルボキシラーゼ活性化剤
JP6139477B2 (ja) メイラード反応生成物分解剤およびそれを用いた飲食品
JP2006022006A (ja) スフィンゴ脂質含有美容健康用組成物
JP4100911B2 (ja) グルタミン酸デカルボキシラーゼ活性化剤
JP2015044773A (ja) ブルーライト照射に起因する皮膚老化予防・改善剤
JP2008247839A (ja) カルコン配糖体を含む抗酸化剤
JP2009234944A (ja) 植物抽出物を含有する化粧品組成物
JP2004107286A (ja) 化粧料組成物及び美容・健康食品組成物
JP2006206532A (ja) ＮＦ−κＢ活性化抑制剤
JP2002138044A (ja) 前駆脂肪細胞分化誘導阻害剤
JP4033808B2 (ja) ヒメフウロ抽出物含有美容・健康用素材
JP2009234939A (ja) 植物由来ポリアミン含有抽出物を含有する化粧品組成物
JP5308042B2 (ja) マンゴー抽出物
JP2009149566A (ja) バイオサーファクタントを含有する化粧品組成物
JP2009234938A (ja) 植物由来ポリアミン含有抽出物を含有する化粧品組成物
JP2009234942A (ja) 植物抽出物を含有する化粧品組成物
JP4109099B2 (ja) 育毛剤有効成分のスクリーニング方法とその利用
JP2010043041A (ja) 化粧品組成物

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2008517667

Country of ref document: JP

Kind code of ref document: A

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07807202

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07807202

Country of ref document: EP

Kind code of ref document: A1