WO2007123156A1 - 体外循環回路の圧力センサ - Google Patents
体外循環回路の圧力センサ Download PDFInfo
- Publication number
- WO2007123156A1 WO2007123156A1 PCT/JP2007/058446 JP2007058446W WO2007123156A1 WO 2007123156 A1 WO2007123156 A1 WO 2007123156A1 JP 2007058446 W JP2007058446 W JP 2007058446W WO 2007123156 A1 WO2007123156 A1 WO 2007123156A1
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- WIPO (PCT)
- Prior art keywords
- pressure
- liquid
- liquid chamber
- chamber
- pressure sensor
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
- A61M1/3641—Pressure isolators
Definitions
- the present invention relates to a pressure sensor that measures a pressure in an extracorporeal circuit that circulates a liquid, particularly a body fluid or a chemical solution.
- FIG. 33 is a schematic configuration diagram showing an example of a configuration of a pressure measurement method using a drip chamber.
- the drip chamber 1 is arranged in the middle of the liquid flow path 8, and the branch tube 500 branched from the upper part of the drip chamber 1 and the liquid chamber arranged at the end of the branch tube 500.
- pressure measuring means 61 In the drip chamber type pressure measurement method as shown in FIG. 33, a certain amount of body fluid or chemical solution, for example, about half the volume, is stored in the drip chamber 12, and the other half is the air layer. Then, extracorporeal circulation therapy is performed. By passing through air, the pressure in the liquid flow path 8 is measured by the air chamber pressure measuring means without directly contacting the body fluid or the chemical solution.
- the drip chamber 12 has a large contact area between the body fluid or the chemical solution and the air due to the size of the inner diameter, and also has a large amount of the stored body fluid or the chemical solution. For this reason, it takes time until the entire stored liquid is replaced with the newly introduced liquid, and there is a possibility that body fluid or chemical solution will be retained or coagulated.
- Patent Document 2 discloses a method of measuring pressure that avoids contact between body fluid or liquid or chemical solution and air. Describes a pressure measuring method for measuring the pressure in the liquid flow path via a deformable portion deformed by the above.
- FIG. 34 is a schematic configuration diagram showing an example of a configuration of a pressure measuring method for measuring the pressure in the extracorporeal circuit via the deformed surface.
- the conventional pressure sensor 3 is disposed in the middle of the liquid flow path 8 and directly determines the deformation amount of the deformation surface 20 at least partially deformed by the pressure in the liquid chamber provided in the liquid chamber 6.
- the pressure in the liquid chamber 6 is measured by detecting indirectly.
- constituent members that perform the same functions as those shown in FIG. 33 are given the same reference numerals.
- the liquid inlet 40 and the liquid outlet 41 are arranged substantially in a straight line. As the introduced liquid flows into the liquid chamber 6 from the liquid inlet 40, sudden expansion of the flow path causes convection at the liquid inlet 40 and stagnation in the flow. Staying at a certain location could cause coagulation of body fluids.
- the depth of the air chamber 9 in the direction perpendicular to the installation direction of the deformed surface 20 has some allowance in consideration of the width of the wavy unevenness. It must be deep (at least larger than the size of the wavy shape). For this reason, the volume of the air chamber 9 cannot be reduced. Therefore, during the negative pressure measurement, the amount of deformation of the deformation surface 20 in the direction of the liquid chamber 6 increases, and as a result, an increase in the volume of the liquid chamber 6 cannot be avoided, and the above-described stagnation is likely to occur.
- the deformed surface 20 in the conventional pressure sensor 3 as shown in FIG. 34 may be damaged due to its softness. If the deformed surface is damaged, the pressure measurement method is the same as that of a drip chamber as shown in Fig. 33, and the above-mentioned coagulation problem due to contact between air and body fluid or chemical solution cannot be prevented.
- the deformation surface 20 is deformed, and the pressure in the air chamber 9 changes in correlation with the pressure in the liquid chamber 6. Therefore, the pressure characteristics are different between the case of measuring through air and the case of measuring through a deformed surface, and there is a problem that the pressure cannot be measured correctly! /, And! /.
- the conventional pressure sensor 3 as shown in FIG. 34 is a disposable disposable product, and it is necessary to connect the pressure sensor to the pressure measuring means every time it is used. Therefore, if this connection is incomplete, a leak will occur between the pressure sensor and the pressure measuring means, making it impossible to correctly measure the pressure. Furthermore, due to leakage, when the volume on the air chamber side becomes infinite and the pressure in the liquid flow path 8 becomes negative pressure, the deformation surface 20 is greatly deformed toward the liquid chamber side. As a result, the liquid inflow port 40 or the liquid outflow port 41 is blocked, and the body fluid or the chemical liquid may not flow, which may induce coagulation of the body fluid.
- Patent Document 3 the pressure is stabilized by adjusting the position of the deformation surface 20 by automatically changing the amount of air on the air chamber 9 side in conjunction with the pressure on the liquid chamber 6 side.
- the pressure sensor to be measured is described.
- FIG. 35 is a schematic configuration diagram showing an example of the configuration of this hydraulic pressure measuring device.
- the conventional pressure sensor 3 in addition to the pressure sensor shown in FIG. 34, the conventional pressure sensor 3 includes a communication part 51 that adjusts the amount of air in the air chamber 9, and a pump 400 disposed on the communication part 51, The valve 401, the air indoor pressure measuring means 60, and the second pressure measuring means 62 are configured.
- components having the same functions as those in FIG. 34 are given the same reference numerals! /
- the hydraulic pressure measuring device shown in FIG. 35 needs to be equipped with various devices such as a pump, a valve, and another pressure measuring means in addition to the pressure sensor for measuring pressure. As a result, the cost of the apparatus cannot be avoided.
- Patent Document 1 JP 2002-282355 A
- Patent Document 2 Japanese Patent Laid-Open No. 09-024026
- Patent Document 3 Japanese Patent Application Laid-Open No. 08-117332 Disclosure of the invention
- the present invention is a pressure sensor that measures the pressure in the extracorporeal circuit without contacting air, and it is difficult for the fluid or drug solution to stay due to flow factors.
- the object is to provide a pressure sensor with a structure that does not cause coagulation of bodily fluids.
- the present invention can continuously measure the pressure even if the pressure fluctuates.
- the purpose of the present invention is to provide a pressure sensor that does not require a large liquid chamber and that can detect pressure with a small amount of measurement error without adjusting the amount of air on the air chamber side with a single type of pressure sensor. To do.
- the present invention provides a pressure sensor that can measure the pressure in the extracorporeal circuit without contact with air, having means for detecting the mounting of the pressure sensor on the mounting surface of the casing. With the goal.
- a pressure sensor according to the present invention includes the following configuration.
- a pressure sensor for an extracorporeal circuit having a liquid chamber, a pressure measuring means, and a liquid flow path, wherein the liquid chamber is separated from the reference surface by a pressure not deformed by the pressure in the extracorporeal circuit.
- a pressure surface in the extracorporeal circuit that forms a deformed surface that is at least partially deformed by the pressure in the extracorporeal circuit, and a liquid-tight space that is closed by connecting the deformed surface and the reference surface.
- a first connection surface that is not deformed by the liquid, a liquid inlet provided on a side surface of the first connection surface, and a liquid inlet introduced from the liquid inlet along the inner periphery of the side surface of the first connection surface.
- a pressure sensor of the extracorporeal circuit which is liquid-tightly connected to the liquid inlet so that the liquid to be flown flows along the inner periphery of the side surface of the first connection surface.
- the pressure sensor of the extracorporeal circuit further includes an air chamber, and the air chamber is spaced from the deformation surface so that the deformation surface is positioned between the reference surface and the opposing surface.
- the opposing surface that is not deformed by the second surface, the second connecting surface that is not deformed by pressure, and forms an airtight space that is closed inside by connecting the opposing surface and the deforming surface, and the second connecting surface
- An air inlet / outlet port provided on a side surface or the opposing surface, and the pressure measuring means is an air chamber pressure measuring means connected to the air inlet / outlet of the air chamber via a communicating portion, (a) or (b) A pressure sensor for the extracorporeal circuit.
- V the volume of the communication part is V
- P the minimum pressure measurable value of the pressure sensor
- V, V, and V are set so as to satisfy both the expressions (1) and (2),
- the deformed surface is such that the pressure in the liquid chamber and the air chamber is P.
- the deformation surface is sandwiched between two containers of the air chamber and the liquid chamber at the periphery thereof and mechanically sealed, and the deformation surface is sandwiched between the two containers.
- the width of the seal portion in contact with the container is L (provided that 0.3 mm ⁇ L ⁇ 10 mm)
- the Poisson's ratio of the deformed surface is V
- the thickness of the deformed surface is h (provided that 0.2 mm ⁇ h ⁇ 3.
- the deforming surface is provided with a ring portion thicker than the deforming surface at the periphery of the deforming surface serving as a seal portion, and the ring portion is sandwiched between the two containers and comes into contact with the container.
- the width of the seal part is La (however, 0.3 mm ⁇ La ⁇ 10 mm)
- the Poisson's ratio of the ring part is va
- the thickness of the ring part is ha (however, 1. Omm ⁇ ha ⁇ 5.
- the liquid chamber and the air chamber have a flat plate shape in a state of atmospheric pressure by mechanically sealing with a tension displacement ⁇ applied so as to satisfy Pressure sensor for extracorporeal circulation circuit.
- a groove for inserting the ring portion is provided in the seal portion of the air chamber and Z or the liquid chamber, and an inner surface of the groove is inclined so as to form an acute angle with respect to the deformation surface.
- Pressure sensor for extracorporeal circuit as described in f) or (g).
- the pressure sensor of the extracorporeal circuit further includes an air chamber atmospheric pressure unit for setting the air chamber to atmospheric pressure, a liquid chamber atmospheric pressure unit for setting the liquid chamber to atmospheric pressure, Liquid chamber pressure adjusting means for adjusting the pressure, liquid chamber pressure measuring means for measuring the pressure in the liquid chamber, and an air chamber corresponding to the pressure in the liquid chamber by changing the pressure in the liquid chamber
- a pressure sensor for an extracorporeal circuit according to any one of (d) and (h), further comprising: a breakage detecting means for detecting breakage of the deformed surface by measuring and comparing the pressures.
- the change characteristic of the pressure in the air chamber corresponding to the pressure in the liquid chamber is stored in advance by the breakage detecting unit, and the air chamber and the liquid chamber are formed by the air chamber atmospheric pressure increasing unit and the liquid chamber atmospheric pressure increasing unit.
- the pressure in the air chamber corresponding to the change in the pressure in the liquid chamber measured by the liquid chamber pressure measuring means when the pressure in the liquid chamber is increased or decreased by the liquid chamber pressure adjusting means.
- the air chamber and the liquid chamber are housed in the same casing, and the pressure sensor of the extracorporeal circuit has a mounting surface on which the casing is further mounted, and the casing is mounted on the mounting surface. There is a mounting detection means for detecting this, and the communication surface that can be connected to the air inlet / outlet of the air chamber is opened on the mounted surface, and the mounting detection means detects the mounting of the casing.
- the pressure sensor of the extracorporeal circuit according to any one of (d) to (1), wherein the air inlet / outlet port and the communication portion are sometimes connected in an airtight manner.
- a buffer part is provided around the opening of the communication part of the mounting surface to apply force to the casing, and the buffer part is movable in the connecting direction of the air inlet / outlet and the communication part.
- the mounting detection means is configured to detect the case when the casing is mounted on the mounting surface.
- the pressure sensor for an extracorporeal circuit according to any one of (m) to (p), which is means for detecting contact between the sing and the mounting surface.
- the mounting detection means is means for detecting that the casing is rotated along the mounting surface and is mounted at a predetermined position, according to any one of (m) to (p). Pressure sensor for extracorporeal circuit.
- the pressure sensor of the extracorporeal circuit has a rotating body around the casing, and the mounting detection means is mounted at a predetermined position by rotating the rotating body along the mounting surface.
- the pressure sensor of the extracorporeal circuit according to any one of (m) to (p), wherein
- FIG. 1 is a schematic diagram of the pressure sensor of this embodiment.
- a pressure sensor 1 is disposed on a liquid flow path 8 and has a reference surface 10 that is not deformed by the pressure in the liquid flow path, and a liquid flow path that is spaced from the reference surface 10.
- a deformation surface 20 that is at least partially deformed by the pressure, and a liquid-tight space that is closed inside by connecting the deformation surface 20 and the reference surface 10 and is not deformed by the pressure in the liquid flow path.
- One connecting surface 11, a liquid inlet 40 provided on the side surface of the first connecting surface 11, and the liquid inlet port 40 were introduced along the inner periphery of the side surface of the first connecting surface 11.
- a liquid chamber 6 having a liquid outlet 41 disposed at a position separated by 1Z2 or more and less than one circle in the liquid flow direction; and the pressure in the liquid chamber 6 by measuring the deformation amount of the deformation surface 20
- the liquid chamber 6 is a means for measuring a load sensor 45 or a strain gauge 46.
- Pressure measuring means 7 arranged outside the liquid inlet 40; the liquid inlet 40 arranged so that the liquid introduced into the liquid chamber 6 flows along the inner periphery of the side surface of the first connecting surface 11 And a liquid channel 8 connected in a liquid-tight manner.
- the pressure sensor 1 is further arranged so as not to be deformed due to pressure, which is spaced from the deformation surface 20 so that the deformation surface 20 is located between the reference surface 10 and the opposing surface 30.
- An opposing surface 30; the opposing surface 30 and the deformation surface 20 are connected and closed inside A second connection surface 31 that forms an airtight space and is not deformed by pressure; and an air chamber 9 that includes an air inlet / outlet port 50 provided on a side surface of the second connection surface 31 or the opposing surface 30.
- the pressure sensor 1 indirectly measures the pressure in the liquid flow path 8 by measuring the pressure change using the air chamber pressure measuring means 60 via the communication portion 51.
- the reference plane 10 is circular, but there is no particular problem even if it is a polygon such as an octagon as shown in FIG. Further, as shown in FIG. 4, there is no particular problem even if the reference surface 10 and the deformation surface 20 have different shapes.
- the reference surface 10 has a flat plate shape, but if the surface shape of the reference surface 10 is uneven, an effect may be exerted on liquid replacement as described later, and the surface shape is particularly limited. is not.
- the reference surface 10 is circular and flat
- the deformation surface 20 is circular
- the reference surface 10 and the deformation surface 20 are the same as shown in FIG. A size shape is preferable.
- the first connecting surface 11 is a force that is linear when viewed from the cross section.
- the contact point between 20 and the first connecting surface 11 may be connected via a slope of about 45 ° connected to 90 °.
- the contact surface may be connected with a contact point between the reference surface 10 and the first connection surface 11 or with a contact force roundness between the deformation surface 20 and the first connection surface 11.
- the reference surface 10 and the deformed surface 20 may have a round shape as a whole.
- the deformation surface 20 has a flat plate shape as shown in FIG. 8, even if it has a triangular wave shape or a sine wave shape as viewed from the cross section. However, it is most desirable to have a flat plate shape for the reason described later.
- the deformation surface 20 is a deformation portion that is a portion that is all deformed in FIGS.
- the area and shape of the deformed portion (deformed portion) in the deformed surface 20 are not particularly limited as long as the area or shape can be any ratio as long as the pressure can be measured correctly.
- the liquid flow path 8 is a force parallel to the reference plane 10, as shown in FIG. 9, even if the liquid flow path 8 is slightly inclined, the effect of the present invention is not reduced.
- the liquid flow path 8 in order to form a smoother liquid flow while pressing, preferably forms an angle of 0 to 30 degrees with respect to the reference plane 10, and more preferably 0 to 15 degrees. Are most preferably parallel.
- the tangential surface 12 of the inner surface of the liquid channel 8 is in contact with the inner surface of the first connection surface 11, and the liquid channel 8 connected to the liquid inlet 40 is completely
- the tangential surface 12 of the inner surface of the liquid flow path 8 is applied to the inner surface force of the first connecting surface 11 in the normal direction. It is desirable that it is located within 3 mm, more preferably within 0-2 mm, most preferably 0-1 mm.
- the liquid outlet 41 is installed at the highest position of the circular shape in FIG. 1, but it may be at a position as shown in FIG. At this time, when the pressure sensor 1 is installed so that the liquid inlet 40 is parallel to the gravity, when the liquid is circulated, air remains in the upper region 65 of the liquid chamber 6 and the pressure sensor 1 Body fluids or chemicals may come into contact with air and eventually cause coagulation. However, if the direction of the pressure sensor 1 is changed during the treatment, the air present in the pressure sensor 1 can be discharged, so the position of the liquid outlet 41 does not reduce the effect of the invention. In particular, the position is not limited.
- the liquid outlet 41 is connected to the first connecting surface 11 from the liquid inlet 40. It is placed at a position 3Z4 away from the liquid inlet 40 in the flow direction of the liquid introduced into the liquid chamber 6 along the inner side of the side surface, and the liquid outflow direction is 180 degrees with respect to the liquid inflow direction.
- the liquid outlet 41 is connected to form an angle of
- the liquid outlet 41 extends in the direction of the liquid introduced from the liquid inlet 40 into the liquid chamber 6 along the inner peripheral surface of the first connection surface 11. Even if connected to the liquid outlet 41 so that the liquid outflow direction forms an angle of 90 degrees with respect to the liquid inflow direction, the effect of the invention is reduced. It is not a thing.
- the liquid outlet 41 is separated from the liquid inlet 40 by 1Z2 or more and less than one turn in the flow direction of the liquid introduced into the liquid chamber 6 along the inner peripheral surface of the first connection surface 11 from the liquid inlet 40. It is particularly preferable that they are arranged at the positions. In addition, the angle of the liquid outflow direction with respect to the inflow direction does not particularly change the flow in the liquid chamber 6, so that the direction may be set appropriately according to the use conditions, and the direction is not particularly limited. Absent.
- the liquid inlet 40 and the liquid outlet 41 viewed from the cross-sectional direction are at the center of the distance between the reference surface 10 and the deformation surface 20.
- the liquid inlet 30 is within the range of 0 to 3 mm, more preferably within the range of 0 to 2 mm from the center of the reference surface 10 and the deformation surface 20. Most preferably, it should be placed within the range of 0 to: Lmm! Note that the outflow direction of the liquid outlet 41 does not affect the flow in the liquid chamber 6, and therefore does not specifically limit the direction that does not reduce the effect of the invention.
- the liquid inlet 40 and the liquid outlet 41 are disposed on the same plane parallel to the reference plane 10. However, even if the liquid inlet 40 and the liquid outlet 41 are not arranged on the same plane parallel to the reference plane 10, as shown in FIG.
- the arrangement is not limited. That is, the liquid inlet 40 and the liquid outlet 41 may be arranged at positions where the distance from the reference plane 10 is different.
- the air inlet / outlet port 50 does not affect the pressure measurement regardless of the position at which the air inlet / outlet port 50 is located at the position farthest from the deformation surface 20 in the air chamber 9. There is no particular limitation.
- the material of the liquid chamber 6 and the air chamber 9 may be either hard or soft. However, if changes occur in the shape of the liquid chamber 6 and the air chamber 9 due to environmental factors such as liquid temperature and temperature, external force that deforms the liquid chamber 6 and the air chamber 9, the liquid flow It becomes difficult to measure the pressure in channel 8. Therefore, the material of the liquid chamber 6 and the air chamber 9 is preferably hard. Furthermore, a material having biocompatibility is preferred because it directly or indirectly touches the patient's body fluid. For example, vinyl chloride, polycarbonate, polypropylene, polyethylene, polyurethane and the like can be mentioned, and any of them can be suitably used. Further, the production method is not particularly limited, but examples thereof include injection molding, blow molding, and molding by cutting.
- the material of the deformed portion (deformed portion) of the deformed surface 20 that is at least partially deformed by pressure is hard, the amount of fluctuation due to pressure is reduced, and the pressure in the liquid channel 8 is accurately measured. It is desirable to use a soft material that can be deformed flexibly against pressure. Furthermore, a material having biocompatibility is preferable because it directly or indirectly touches a patient's body fluid. For example, polyvinyl chloride, silicon-based resin, styrene-based thermoplastic elastomer, styrene-based thermoplastic elastomer compound and the like can be exemplified, and any of them can be suitably used. With respect to the material of the other parts (the part that does not deform), there is no particular problem as long as it is the same material as the liquid chamber 6 and the air chamber 9 described above.
- the material of the liquid flow path 8 may be any of synthetic resin, metal, glass and the like! /,
- synthetic resin, particularly thermoplastic resin is preferable from the viewpoint of manufacturing cost, workability and operability.
- thermoplastic resins include polyolefin resins, polyamide resins, polyester resins, polyurethane resins, fluorine resins, silicone resins, and ABS (acrylonitrile, butadiene, styrene copolymer).
- (Coalescence) Examples include rosin, polychlorinated bur, polycarbonate, polystyrene, polyatarylate, polyacetal, etc. Can be used. Of these, soft materials are preferred because they have excellent flexibility during operation that is resistant to bending and cracking.
- the reason for assemblability is particularly preferred for soft salty bulls.
- the communication part 51 may be any of synthetic resin, metal, glass, etc. as long as it communicates the air chamber 30 and the air chamber pressure measuring means 60. From the viewpoint of production cost, processability and operability, a synthetic resin, particularly a thermoplastic resin is preferred.
- Thermoplastic resins include polyolefin resins, polyamide resins, polyester resins, polyurethane resins, fluorine resins, silicone resins, and ABS (acrylonitrile, butadiene, styrene).
- copolymer resin examples include polychlorinated bur, polycarbonate, polystyrene, polytalylate, polyacetal and the like, and any of them can be suitably used.
- soft materials are preferred because of their excellent flexibility during operation, which is resistant to bending and cracking.
- Reasonable power of assemblability Soft salt bubul is particularly preferred.
- Each joining method of the liquid chamber 6, the air chamber 9, and the liquid flow path 8 is not particularly limited, but generally synthetic resin joining includes hot-melt joining and adhesion.
- hot melt welding high frequency welding, induction heating welding, ultrasonic welding, friction welding, spin welding, hot plate welding, hot wire welding and the like can be mentioned.
- the adhesive include cyanoacrylates, epoxies, polyurethanes, synthetic rubbers, ultraviolet curables, modified acrylic resins, hot melts, and the like.
- the method of joining the deformed portion (deformed portion) and the other portion (not deformed !, portion) is not particularly limited.
- the joining of a hard material and a soft material includes a mechanical seal that seals a soft material by pressing the hard material, and a hot-melt joining or adhesion as described above.
- Such a pressure sensor 1 may be used as it is after being molded and joined, but is sterilized and used particularly in medical applications for extracorporeal circulation therapy.
- the sterilization method may be sterilized by chemical solution, gas, radiation, high-pressure steam, heating, etc. according to the normal medical device sterilization method.
- the reference plane 10 has a diameter of 15 mn! ⁇ 40mm is preferred, more preferably about 20mm ⁇ 30mm.
- the height of the connecting surface 12 is 5mn! ⁇ 20mm is more preferred, more preferably 5mn! It is desirable to be ⁇ 10mm. The shape is described in the design method described later.
- the inner diameter of the liquid channel 8 may be selected according to each extracorporeal circulation therapy and is not particularly limited.
- a main tube having an inner diameter of about 2 mm to 5 mm is generally selected.
- the cross-sectional shape of the liquid flow path 8 is not a circular cross-section, but a non-circular cross-section including an ellipse, a rectangle, or a hexagon.
- the liquid to be circulated through the pressure sensor 1 is not particularly limited as long as it is a body fluid or a chemical solution.
- body fluids include blood, plasma, lymph, tissue fluid, mucus, hormones, site force in, urine and the like.
- the drug solution include physiological saline, anticoagulant, fresh frozen plasma, dialysate, albumin solution, filtration type artificial kidney replacement fluid, and the like.
- FIG. 14 is a schematic diagram of the pressure sensor 1.
- the same reference numerals are used for the same parts as those in the above-described embodiment and the parts having the same functions, and the description thereof is omitted.
- one baffle plate 66 is installed in the vicinity of the connection surface between the liquid inlet 40 and the liquid outlet 41 in the pressure sensor 1 of the above embodiment.
- the baffle plate 66 is for disturbing the flow of fluid. By arranging the fluid introduced into the liquid chamber 6 so as to flow in substantially parallel to the reference surface 10 along the inner circumference of the first connection surface 11, the fluid is circulated in the liquid chamber 6. By creating a flow, it is possible to prevent bodily fluids or chemicals from staying!
- the baffle plate 66 for disturbing the flow of the fluid is installed in the vicinity of the connection surface between the liquid inlet 40 and the liquid outlet 41, so that the liquid in the casing is more efficiently obtained. It becomes possible to promote the replacement. In other words, in addition to the flow that circulates in the liquid chamber 6, a turbulent flow in the center of the liquid chamber 6 is created to strengthen the turbulence in the liquid chamber 6. Replacement at an early stage becomes possible.
- the installation position of the baffle plate 66 is not particularly limited, but is preferably arranged at a position in contact with the first connection surface 11 with the highest flow velocity.
- the baffle plate 66 is installed at a position adjacent to the liquid outlet 41 between the liquid inlet 40 and the liquid outlet 41 that is longer in distance.
- the baffle plate 66 is installed on the first connection surface 11 facing the liquid outlet 41 and does not reduce the effect of the invention.
- the position is not particularly limited.
- the width of the baffle plate 66 in the diameter direction is preferably about 5% to 15%, more preferably about 10% to 15%, with respect to the diameter of the reference surface 10.
- a height of about 30% to 80% with respect to the height of the side surface of the connecting surface 11 is preferred.
- a height of about 50% to 70% is more preferred, but there is no particular limitation.
- the shape of the baffle plate 66 may be a polygon such as a triangle as shown in FIG. 14 when viewed from the reference plane 10 or a shape whose corners are rounded to some extent. There are no particular limitations on the problems as long as they can exhibit the above effects.
- the number of baffle plates 66 installed in FIG. 14 can improve the effect of the invention by installing two or more forces, which is one.
- the number of installations at that time and the interval between the baffle plates 66 are not particularly limited as long as they are appropriately set according to the flow rate used. However, if the interval is too close, there is no point in installing multiple baffle plates 66.
- the distance between the baffle plates 66 is preferably 15% to 25% or more with respect to the circumferential length of the first connection surface 11, and more preferably 20% to 25% or more.
- the pressure sensor 1 includes an air chamber 9 having an air inlet / outlet 50, a liquid chamber 6 having a liquid inlet 40 and a liquid outlet 41, and an air chamber 9 sandwiched between the air chamber 9 and the liquid chamber 6. And the liquid chamber 6 are connected to the deformed surface 20 that deforms according to the pressure difference between the air chamber and the liquid chamber, and the air inlet / outlet 50 of the air chamber 9 through the communication portion 51 to deform the pressure in the liquid chamber.
- An air chamber pressure measuring means 60 for measuring on the air chamber side via the surface 20 is constituted.
- the deformation surface 20 is deformed by being directed toward the air chamber when the liquid chamber is positive. Therefore, the volume of the air chamber 9 needs to be secured so that the deformable surface 20 can be deformed at the assumed maximum pressure.
- the initial volume of the air chamber 9 is V
- the initial pressure of the air chamber 9 is P
- the pressure can be measured even under the maximum pressure.
- the initial state means the start of pressure measurement.
- Gauge pressure is the pressure measured with reference to atmospheric pressure
- absolute pressure is the pressure measured with reference to vacuum.
- the deforming surface 20 is deformed by directing the liquid chamber toward the liquid chamber when the liquid chamber has a negative pressure. Therefore, the volume of the liquid chamber 6 needs to be secured so that the deformable surface can be deformed at the assumed minimum pressure.
- the initial volume of the liquid chamber 6 is V, and the minimum pressure measurable value of the pressure sensor is P.
- the volume of the liquid chamber is preferably 1 ml to: LO ml, more preferably 2 ml to 5 ml.
- the volume of the air chamber 9 is preferably 0.2 ml to: L Oml, more preferably 0.3 ml to 0.8 ml. Therefore, the formula (2b) needs to further satisfy the formula shown by the formula (2).
- the volume of the air chamber 9 does not include the air inlet / outlet port 50.
- the volume of the communication part 51 includes the volume of the air inlet / outlet port 50 and the volume inherent in the air chamber pressure measuring means 60.
- the volume of the liquid chamber 20 does not include the volume of the liquid inlet 40 and the volume of the liquid outlet 41.
- the pressure P of the air chamber 9 in the initial state is often the atmospheric pressure P.
- pre-pressurize the positive pressure side is often the atmospheric pressure P.
- the P P pressure measurable range is the range that can normally be used in blood purification.
- the volume of the communication part 51 is preferably 0.5 ml or less, more preferably 0.5 ml or less, and most preferably 0.2 ml or less.
- the volumetric force Oml of the communicating part 51 including the air inlet / outlet 50 is an ideal force. Since there is a small volume in the air chamber pressure measuring means 60, it cannot be Oml. . Therefore, equation (1) does not hold!
- the seal portions 100 and 101 sandwiched between the two containers of the deformable surface 20 may have different lengths. However, for the reasons of molding and assembling, it is preferable to have point symmetry about the center of the deformed surface.
- the deformed surface 20 is flat when the pressure in the air chamber 9 and the liquid chamber 6 is atmospheric pressure P.
- the air chamber 9 and the liquid chamber 6 are partitioned.
- the deformed surface 20 defines the air chamber 9 and the liquid chamber 6, and the means for obtaining the airtightness of each container is not particularly limited. Examples include hot melt bonding and adhesion as described above, and mechanical sealing.
- the mechanical seal means that airtightness is obtained by inserting rubber or the like.
- the thickness of the deformed surface 20 is h
- the amount of compression is t
- the Poisson's ratio (the difference from the transverse strain that occurs simultaneously when a certain object is subjected to longitudinal or compressive strain) is V
- the deformed surface 20 is
- the length of the seal parts 100 and 101, which are sandwiched between two containers and the container and the deformed surface 20 are in contact with each other is L
- the deformed surface against compression in the direction of the arrow 110 20 is known to expand in the direction perpendicular to the compression direction by the amount of the equation (3a).
- Equation (3a) Assuming that expansion occurs evenly on the left and right, half of the expansion amount shown in Equation (3a) expands in the direction of the force toward the center of the deformation surface 20. Therefore, by performing mechanical sealing while pulling at least half the amount of the equation shown in equation (3a) in the direction of arrow 111 shown in FIG. 17, the deformed surface 20 moves toward the center of the deformed surface 20. Even if it expands in the direction, it is possible to perform sealing without changing the initial position of the deformation surface 20. Therefore, the amount ⁇ to apply the tension satisfies equation (3)! / V X L X (t ⁇ h) / 2 ⁇ e... (3)
- the deformed surface 20 and the portion sandwiched between the two containers are configured to be parallel to each other.
- the seal portions 100 and 101 are inclined at an angle with respect to the deformation surface 20, as shown in FIG. 19, at least one surface of the portion sandwiched between the two containers is rectangular, There is no particular problem even with a structure provided with irregularities 120 such as a triangle or a wave. From the viewpoint of manufacturing cost and assemblability, it is preferable that the deformed surface 20 and the portion sandwiched between the two containers are parallel and the surface is flat.
- the deformation surface 20 is formed in a flat plate shape, and if the applied tension satisfies the equation (3), the air chamber 9 It does not change the volume.
- the yield point means that the deformation occurs without increasing the force, and beyond this point, the material does not return to its original shape even when deformed.
- the amount of tension can be applied to the value obtained by subtracting the amount of deformation of the deformed surface from the value until the yield point is reached.
- the amount of tension applied to the deformed surface is preferably 1 to 5 times the minimum value of Equation (3), more preferably 1 to 3 times.
- the cross-sectional shape of the air chamber 9 is a quadrangle, but there is no particular problem even if it is a dome shape or a polygonal shape. A dome shape that can most easily follow the deformation of the deformation surface is preferable.
- the deformation surface 20 is sandwiched between the air chamber side container and the liquid chamber side container and mechanically sealed at the peripheral edge thereof.
- the shape of the part to be sealed and the diaphragm such as a circle, an ellipse, a rectangle, or a polygon.
- the shape of the part to be sealed and the deformed surface is particularly preferably circular for reasons of molding and assembly.
- the amount of pressure difference correction increases. That is, when the inner diameter is small, the same volume is changed as when the inner diameter is large, so that the deformation amount of the deformation surface 20 is larger than when the inner diameter is large. As the amount of deformation of the deformation surface 20 increases, the force required to deform the deformation surface 20 increases, and the proportional relationship between this force and the amount of deformation of the deformation surface 20 breaks down. The pressure difference in the air chamber will increase and the amount of correction will increase.
- the inner diameter of the deformed surface 20 is larger than the sealed portion of the deformed surface 20, the difference between the inner diameter of the liquid inlet and the inner diameter of the deformed surface is increased. It is easy to cause retention of body fluids or chemicals. Therefore, from the part to be sealed
- the inner diameter is preferably 10-50mm, more preferably 20mn! ⁇ 30mm.
- the thickness of the deformed surface 20 is 0.2mn! ⁇ 3. Omm is preferred 0. 3mn! More preferably, it is 0.7 mm.
- the compression amount (t) is generally such that when mechanical sealing is performed, the ratio (tZh) to the thickness (h) of the deformed surface is about 50% or less, and more preferably 5 Although compression of about 50% to 50% is performed, there is no problem if the amount of compression is determined appropriately so that there is no leakage.
- the width L of the seal portions 100 and 101 is too small, the sealing ability cannot be exhibited. If the width L is too large, the pressure sensor becomes large. Therefore, the width L is 0.3mn! ⁇ 10mm is preferable 0.3mn! More preferably, it is ⁇ 5 mm. When it has a shape like a ring part described later in the third embodiment, it is possible to reduce the width L of the seal parts 100 and 101, which is effective for downsizing the apparatus.
- FIG. 20 is a schematic diagram of a deformed surface of the pressure sensor of the present embodiment.
- Figure 20 (a) is a side view of the deformed surface.
- FIG. 20 (b) is a plan view of the deformed surface.
- symbol is attached
- the flat deformation surface 20 is sealed, for example, when the thickness of the deformation surface 20 is 0.5 mm, assuming that 20% compression is performed, 0.1 mm compression is performed. It turns out that. However, when the thickness of the deformed surface 20 is as thin as 0.5 mm and the compression of 0.1 mm is performed, high accuracy is inevitably required during production, leading to an increase in cost.
- the ring portion 130 is provided along the periphery of the deformation surface 20 (the thinly painted portion in FIG. 20).
- the ring portion 130 is thicker than the deformation surface 20.
- the thickness of the ring portion 130 is not particularly limited. However, if it is too thick, it will lead to an increase in the size of the sensor, and if it is too small, the allowable manufacturing error will be narrowed. Therefore, lmn is preferable to be 1mm ⁇ 5mm! More preferably, it is ⁇ 3 mm.
- the ring portion 130 has a quadrangular cross-sectional shape.
- Generally known cross-sectional shapes of sealing materials include circular, elliptical, triangular, and X-rings, and any of them can be suitably used. From the viewpoint of manufacturing cost and assemblability, a circular shape is most preferable.
- the deformation surface 20 is joined at the center of the cross section of the ring portion 130. There are no particular limitations on the position of the connection, even if it is at the upper end Z lower end of the cross section of the ring portion or between them.
- the tensile displacement can be easily detected on the deformable surface 20.
- grooves are provided in the seal portions 100 and 101 of the air chamber 9 and Z or the liquid chamber 6, and a ring portion 130 is inserted in the groove.
- a tensile displacement is automatically added when performing mechanical sealing.
- the inner side surface of the groove for inserting the ring portion 130 in FIG. 21 is inclined so as to form an acute angle with respect to the deformed surface 20, and is configured such that the ring portion expands when performing mechanical sealing. .
- various examples can be presented, and the means is not particularly limited.
- FIG. 22 is a schematic diagram of another pressure sensor according to this embodiment.
- the pressure sensor 1 includes an air chamber 9 having an air inlet / outlet 50, a liquid chamber 6 having a liquid inlet 40 and a liquid outlet 41, and air sandwiched between the air chamber 9 and the liquid chamber 6.
- the casing 4 is arranged in the middle of the liquid channel 8 and measures the pressure in the liquid channel 8.
- the deformation surface 20 is deformed by the change in the pressure in the liquid chamber 6, and the pressure in the air chamber 9 changes in correlation with the pressure in the liquid chamber 9.
- the pressure in the liquid chamber 6 is measured by conversion.
- the breakage detecting means 5 is configured such that the pressure in the air chamber 9 and the liquid chamber 6 is made atmospheric by the air chamber atmospheric pressure making means 81 and the liquid chamber atmospheric pressure making means 80 and then the liquid chamber pressure adjusting means 70 makes the liquid pressure.
- the pressure in the body chamber 6 is increased and the deformed surface 20 comes into close contact with the wall surface of the air chamber 9, the pressure in the liquid chamber 6 is set to P1, and further the pressure in the liquid chamber 6 is adjusted by the liquid chamber pressure adjusting means 70.
- P2 > P1
- the pressure in the air chamber 9 becomes larger than P1, it is determined that the deformed surface 20 is damaged.
- the air chamber atmosphericization means 81 and the liquid chamber atmosphericization means 80 are closed and the pressure in the liquid flow path 8 is gradually decreased using the liquid chamber pressure adjustment means 70, At some point, the deformation surface 20 contacts the wall surface of the liquid chamber 6 and no further deformation occurs. Ie it It becomes impossible to make the following pressure measurements. Assuming that the pressure at this time is P3, when the pressure is further decreased and reaches a pressure P4 smaller than P3, the pressure measuring means 61 in the liquid chamber 61 indicates the pressure of P4. The pressure measuring means 60 in the air chamber 60 measures the pressure of P3. As shown.
- the pressure in the air chamber pressure measuring means 60 is measured when the pressure reaches P4 because the air chamber pressure measuring means 60 and the liquid flow path 8 communicate with each other. Since it becomes P4, it can be judged that the deformed surface is damaged.
- the breakage detecting means 5 is configured such that the pressure in the air chamber 9 and the liquid chamber 6 is made atmospheric by the air chamber atmospheric pressure making means 81 and the liquid chamber atmospheric pressure making means 80 and then the liquid chamber pressure adjusting means 70 makes the liquid pressure.
- the pressure in the body chamber 6 is decreased and the deformed surface 20 comes into close contact with the wall surface of the liquid chamber 6, the pressure in the liquid chamber 6 is set to P3, and the pressure in the liquid chamber 6 is further adjusted by the liquid chamber pressure adjusting means 70.
- P4 ⁇ P3
- the initial pressure when starting to increase or decrease the pressure using the pressure adjusting means 70 in the liquid chamber, the internal volumes of the liquid chamber 6 and the air chamber 9 are stable, that is, the initial pressure is stable. Otherwise, the pressure at P1 and P3 will change each time it is measured, making it impossible to measure correctly. Therefore, in the initial stage of detecting the deformation surface breakage, the initial pressures of the liquid chamber 6 and the air chamber 9 must be the same every time they are detected. Therefore, in setting the initial pressure, in order to obtain the atmospheric pressure that can be set most easily, before starting to increase or decrease the pressure using the liquid chamber pressure adjusting means 70, the air chamber aeration means 81 and the liquid chamber By opening the atmospheric means 80, the pressure in the liquid chamber 6 and the air chamber 9 can be set to atmospheric pressure.
- Air chamber pressure measuring means 60 pressure is P1 or more or P3 or less respectively. Make sure not,
- the pressures P1 and P3 vary depending on the shape and material of the air chamber 9, the liquid chamber 6, and the deformed surface 20, but can be measured by the above method.
- the magnitudes of the pressures P2 and P4 for determining the breakage of the deformed surface 20 are not particularly limited. However, if the pressure is too large or too small, the load applied to the liquid flow path 8 increases. Therefore, the pressure of P2 is preferably in the range of 1 3 1 + 1011111113 ⁇ 4 ⁇ 1 3 1 + 30011111113 ⁇ 4, more preferably 1 3 1 + 1011111113 ⁇ 4 ⁇ 1 3 1 + a range of 20011111113 ⁇ 4 Ari, most preferably rather is ! ⁇ +: ⁇ ! ! ! ! ! ! ! ! ! ⁇ ⁇ ! ⁇ + ⁇ ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! !
- the pressure of P4 is preferably in the range of P3—10 mmHg to P3—300 mmHg, more preferably in the range of P3—10 mmHg to P3—200 mmHg, and most preferably in the range of P3—10 mmHg to P3—100 mmHg. It is.
- the liquid chamber pressure adjusting means 70 may be a pump capable of supplying gas.
- a tube pump with a function of stopping the flow of the liquid when the pump stops and feeding the liquid by squeezing the tube is even better.
- the rotary tube pump includes an elastic tube forming a liquid feeding path and a rotating body having a plurality of rollers attached to the outer periphery, and the plurality of rollers pull the tube by rotating the rotating body. It is structured to feed liquid while squeezing.
- the tube is regulated in an arc shape, and the center of the arc becomes the center of the rotating body, and the plurality of rollers rotate and revolve while rotating the tube to feed liquid.
- Examples of the liquid chamber atmosphericization means 80 and the air chamber atmosphericization means 81 include forceps, a manual clamp, and an electric valve.
- the electric valve can be a rotary solenoid system, a push-pull system, etc. Anything can be used as long as it can close and open the liquid flow path 8 or the branch line 52 of the communication part 51.
- the air chamber atmosphericization means 81 may have a structure as shown in FIG. 23 which does not include the branch line 52 of the communication portion 51 and the air chamber atmosphericization means 81 as described above.
- the casing 4 has a structure that can be detached from the communication part 51, and the casing 4 is removed from the communication part 51 by using the connecting means 55 of the communication part 51.
- the shape which can perform simultaneously can be mentioned.
- Examples of the connecting means 55 of the communication portion 51 include a luer connector method, a coupler method, and insertion of a sleeve-like tube. Anything can be used as long as the casing 4 and the communication part 51 can be connected in an airtight manner. Further, in FIG. 23, the casing 4 has a shape in which the communication part 51 is attached. However, the connecting means 55 of the communication portion 51 is not particularly limited even if the shape is directly connected to the casing 4 and does not reduce the effect of the invention.
- each pressure measuring means 60 is ideal as a pressure sensor. 61 pressures are the same. However, in actuality, the pressure measured by the pressure measuring means 60 in the liquid chamber increases as the pressure in the liquid flow path 8 increases or decreases. A small amount of pressure is measured.
- the pressure in the liquid flow path 8 measured by the liquid chamber pressure measuring means 61 is a linear straight line as shown in the pressure characteristic 90, but the same pressure is applied to the air chamber pressure.
- the pressure characteristic 91 an amount of pressure smaller than the pressure characteristic 90 is measured. Therefore, when the pressure measured by the air chamber pressure measuring means 60 is the same as the pressure measured by the liquid chamber pressure measuring means 61, it can be determined that the deformation surface 20 is damaged.
- the pressure measured by the air chamber pressure measuring means 60 is stored in advance. Judge whether the same characteristics as the characteristics,
- the pressure characteristic 90 measured using the air chamber pressure measuring means 60 varies depending on the shape and material of the liquid chamber 6 and the deformed surface 20, but can be measured by the above method.
- the breakage detecting means 5 stores in advance the change characteristics of the pressure in the air chamber 9 corresponding to the pressure in the liquid chamber 6, and the air is detected by the air chamber atmospheric pressure generating means 81 and the liquid chamber atmospheric pressure increasing means 80. After the pressure in the chamber 9 and the liquid chamber 6 is changed to atmospheric pressure, when the pressure in the liquid chamber 6 is increased or decreased by the liquid chamber pressure adjusting means 70, the liquid chamber 6 measured by the liquid chamber pressure measuring means 61 is measured. The change force of the pressure in the air chamber 9 corresponding to the change in pressure in the air chamber 9 When it is different from the pressure change characteristic in the air chamber 9 that was previously recorded, it is judged that the deformed surface 20 is damaged. is there.
- the pressure sensor 1 is divided into an air chamber 9 having an air inlet / outlet 50, a liquid chamber 6 having a liquid inlet 40 and a liquid outlet 41, and an air chamber 9 and a liquid chamber 6 sandwiched between the air chamber 9 and the liquid chamber 6.
- a casing 4 disposed in the middle of the liquid flow path 8 composed of a deformation surface 20 that deforms according to a pressure difference between the air chamber 9 and the liquid chamber 6; and a surface 300 to be attached to the air inlet / outlet 50
- An air chamber pressure measuring means 60 for measuring the pressure in the liquid chamber 6 on the air chamber side through the deformation surface 20; A surface 300; and mounting detection means 210 for determining the close contact between the casing 4 and the mounting surface 300.
- the pressure sensor 1 is disposed in the middle of the liquid channel 8 and measures the pressure in the liquid channel 8.
- the pressure sensor 1 measures the pressure in the air chamber 9 because the deformation surface 20 is deformed by the change in the pressure in the liquid chamber 6 and the pressure in the air chamber 9 changes in correlation with the pressure in the liquid chamber.
- the pressure in the liquid chamber 6 is measured by converting the value.
- the air inlet / outlet port 50 of the casing 4 and the air chamber pressure measuring means 60 communicate with each other through the communication part 51.
- the pressure sensor 1 is configured such that the communication part 51 and the air inlet / outlet port 50 are hermetically connected when the casing 4 comes into contact with the mounting detection means 210!
- connection method of the air inlet / outlet port 50 and the communication part 51 examples include a method using a luer connector, a method using a coupler, and insertion of a sleeve-like tube. There is no particular limitation as long as the air inlet / outlet port 50 and the communication part 51 can be connected in an airtight manner.
- the mounting detection means 210 is installed on the force casing 4 installed on the mounted surface 300 in FIG. 25, the above effect is not impaired.
- the normal casing 4 is a product that is used and discarded as described above, it is disadvantageous in terms of cost to install expensive parts such as attachment detection means on the casing side. Therefore, it is desirable that the mounting detection means 210 is installed on the mounting surface 300.
- the attachment detection means 210 may be anything that can detect the joining between the casing 4 and the mounting surface 300.
- force S that can include microswitches and hall elements, etc., not particularly limited
- the attachment detection means 210 is arranged on the surface of the attachment surface 300 so as to come into contact with the surface of the air chamber 9 of the casing 4.
- the attachment detection means 210 is arranged on the surface of the attachment surface 300 so as to come into contact with the surface of the air chamber 9 of the casing 4.
- the casing 4 is mounted at an angle of 90 ° with respect to the mounting surface 300.
- an angle of 70 ° is acceptable. It is preferably mounted at an angular force of 70 ° to 90 °, more preferably at an angle of 80 ° to 90 °, and most preferably at 90 ° due to the workability of the casing 4 and the mounting surface 300. Mounted from an angle.
- both the mounting surface of the casing 4 and the bonding surface of the mounted surface 300 are flat surfaces.
- problems include a wave shape and a sine wave shape. In any case, the effect of the invention is not particularly limited.
- the joint between the casing 4 and the mounting surface 300 is only the air inlet / outlet port 50 and the communication part 51 in FIG.
- a fixing device 220 for the casing 4 is arranged.
- the fixing device 220 is installed on the mounting surface 300 in FIG. Even if the fixing device is installed on the casing 4 side, the above effect is reduced. There are no particular limitations on what you want.
- the fixing device 220 is not particularly limited as long as it can prevent the casing 4 from falling off the mounting surface 300.
- the casing 4 and the air chamber pressure measuring means 60 are connected directly to the communication portion 51 from the air inlet / outlet port 50.
- the communication part connection port 53 is arranged at the tip, and the part and the communication part 51 are connected.
- the attachment detection means 210 detects the connection between the communication port 53 and the attachment surface 300.
- it is desirable to fix the communication portion mounting port 53 using a fixing device as shown in FIG. There is no problem as long as the shape of the communication port 53 is the same as that of the air inlet / outlet port 50 described in FIG. Even if the wear detection means 210 is installed at the communication port 53, it does not reduce the above effect!
- the casing 4 is attached to the fixing device 220 by being attached in a direction perpendicular to the attachment surface.
- FIG. 29 there is a particular limitation in that the above effect is not reduced even if a means for fixing by rotating the casing 4 along the mounting surface 300 is inserted into the key-type fixing device 220. is not.
- FIG. 30 there is no particular limitation as long as the mounting detection means 210 is disposed at the place where the casing 4 has finished rotating, the above-mentioned effect is not reduced.
- the casing 4 since the casing 4 is disposed in the middle of the liquid flow path 8, rotating the casing 4 requires rotation of the entire liquid flow path 8 and requires a large amount of labor. Therefore, as shown in FIG. 31, by arranging the rotating body 240 around the casing 4, the mounting method as shown in FIGS. 29 and 30 can be performed without rotating the casing 4.
- the buffer portion 250 may be anything as long as it moves in the connecting direction of the casing 4 and a force is applied toward the casing 4.
- a force is applied toward the casing 4.
- it is not particularly limited.
- it is still desirable to install the movement guide 260 in order to limit the operation direction of the buffer portion 250 to the connection direction of the casing 4.
- the material of the fixing device 220 and the rotating body 240 may be any of synthetic resin, metal, glass, and the like, but it is preferable that it is hard in terms of operability. Further, from the viewpoint of manufacturing cost, additivity and operability, synthetic resins, particularly thermoplastic resins are preferable.
- thermoplastic resins include polyolefin resins, polyamide resins, polyester resins, polyurethane resins, fluorine resins, silicone resins, and ABS (acrylonitrile, butadiene, Styrene copolymer) resin, polychlorinated bur, polycarbonate, polystyrene, polyacrylate, polyacetal and the like can be exemplified, and any of them can be suitably used.
- the first liquid flowing through the liquid flow path 8 and the pressure sensor 1 is pumped as vermilion colored water using a liquid feed pump at a flow rate of 50 mlZ, and the liquid flow path 8 and the pressure sensor 1 was filled.
- a soft salt tube tube having an inner diameter of 3.3 mm was connected to the inlet side and the outlet side of the pressure sensor 1, respectively, and the peristaltic pump was installed on the inlet side circuit as the liquid feed pump.
- the test was performed using the liquid flow path 8 and the pressure sensor 1 in FIG. 1 in which the diameter of the reference surface 10 and the deformation surface 20 is 20 mm, and the height of the first connection surface is 10 mm.
- the reference surface 10, deformed surface 20, and connecting surface 11 were made of polycarbonate. The purpose is to measure the displacement efficiency, and no pressure measurement is performed.
- the part (deformation part) to perform was not provided.
- the time until the inside of the casing was replaced with transparent tap water was 120 seconds.
- Comparative Example 1 a test similar to that of the first embodiment was performed using the pressure sensor of FIG. 34 having the same dimensions and the liquid inlet 30 and the liquid outlet 31 arranged substantially linearly. As a result, the time until the inside of the casing was replaced with transparent tap water was 450 seconds.
- the fluid introduced into the casing having the liquid inlet 30 and the liquid outlet 31 provided on the connection surface 12 is arranged so as to flow along the inner peripheral surface of the connection surface 12.
- the pressure sensor of the present invention has a low risk of causing coagulation of body fluids. Therefore, the pressure in the extracorporeal circuit can be safely measured in the extracorporeal circulation therapy in which the patient's internal force blood is taken out, subjected to the extracorporeal treatment of the blood using the blood processing apparatus, and the treated blood is returned to the body. Therefore, the pressure sensor of the present invention can be usefully used for extracorporeal circulation therapy. In addition, the pressure sensor of the present invention can detect liquid pressure with little measurement error in a state where the liquid does not contact air.
- the pressure sensor of the present invention can be usefully used for extracorporeal circulation treatment.
- the pressure sensor of the present invention can detect in advance the breakage of the flexible diaphragm of the pressure sensor, and can ensure safety as a pressure sensor. Therefore, the pressure in the extracorporeal circuit can be safely measured in the extracorporeal circulation therapy in which blood is taken out from the patient's body, subjected to the extracorporeal treatment of the blood using a blood treatment apparatus, and the treated blood is returned to the body. Therefore, the pressure sensor of the present invention can be usefully used for extracorporeal circulation therapy. Furthermore, the pressure sensor of the present invention reliably detects the connection between the casing of the pressure sensor and the mounting surface. I can go out.
- the pressure sensor of the present invention can be usefully used for extracorporeal circulation treatment.
- FIG. 1 is a schematic diagram of a front view (A) and a side view (B) showing an embodiment of a pressure sensor of the present invention.
- FIG. 2 is a schematic diagram of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 3 is a schematic view of a front view (A) and a side view (B) showing still another embodiment of the pressure sensor of the present invention.
- FIG. 4 is a schematic view of a front view (A) and a side view (B) showing still another embodiment of the pressure sensor of the present invention.
- FIG. 5 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 6 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 7 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 8 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 9 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 10 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 11 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 12 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 13 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 14 is a schematic diagram of a front view (A) and a side view (B) showing still another embodiment of the pressure sensor of the present invention.
- FIG. 15 is a schematic view of a front view (A) and a side view (B) showing still another embodiment of the pressure sensor of the present invention.
- FIG. 16 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 17 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 18 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 19 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 20 is a schematic diagram showing still another embodiment of the pressure sensor of the present invention.
- FIG. 22 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 23 is a schematic diagram showing still another embodiment of the pressure sensor of the present invention.
- FIG. 24 is a schematic view showing still another embodiment of the pressure sensor of the present invention.
- FIG. 25 is a schematic diagram of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 26 is a schematic diagram of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 27 is a schematic view of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 28 is a schematic view of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 29 is a schematic diagram of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 30 is a schematic view of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 31 is a schematic diagram of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 32 A schematic view of a front view (A) and a side view (B) showing another embodiment of the pressure sensor of the present invention.
- FIG. 33 is a schematic diagram showing a conventional pressure sensor.
- FIG. 34 is a schematic diagram showing a conventional pressure sensor.
- FIG. 35 is a schematic diagram showing a conventional pressure sensor.
- Damage detection means for detecting deformation surface damage Liquid chamber
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Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/282,072 US7748275B2 (en) | 2006-04-19 | 2007-04-18 | Pressure sensor for extracorporeal circulating circuit |
KR1020087019557A KR101096296B1 (ko) | 2006-04-19 | 2007-04-18 | 체외 순환 회로의 압력 센서 |
CN2007800137074A CN101421602B (zh) | 2006-04-19 | 2007-04-18 | 体外循环回路的压力传感器 |
ES07741882.0T ES2544955T3 (es) | 2006-04-19 | 2007-04-18 | Sensor de presión para circuito de circulación extracorporal |
CA2649357A CA2649357C (en) | 2006-04-19 | 2007-04-18 | Pressure sensor for extracorporeal circulating circuit |
EP07741882.0A EP2009415B1 (en) | 2006-04-19 | 2007-04-18 | Pressure sensor for extracorporeal circulating circuit |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006115852A JP5007410B2 (ja) | 2006-04-19 | 2006-04-19 | 圧力センサ |
JP2006-115852 | 2006-04-19 | ||
JP2006-228483 | 2006-08-24 | ||
JP2006228483A JP2008051663A (ja) | 2006-08-24 | 2006-08-24 | 圧力センサ |
JP2007102486A JP4869133B2 (ja) | 2007-04-10 | 2007-04-10 | 可撓性隔膜の破損検出方法とそれに用いる圧力センサ |
JP2007102487A JP2008259553A (ja) | 2007-04-10 | 2007-04-10 | 圧力センサ |
JP2007-102487 | 2007-04-10 | ||
JP2007-102486 | 2007-04-10 |
Publications (1)
Publication Number | Publication Date |
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WO2007123156A1 true WO2007123156A1 (ja) | 2007-11-01 |
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ID=38625056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/JP2007/058446 WO2007123156A1 (ja) | 2006-04-19 | 2007-04-18 | 体外循環回路の圧力センサ |
Country Status (8)
Country | Link |
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US (1) | US7748275B2 (ja) |
EP (1) | EP2009415B1 (ja) |
KR (1) | KR101096296B1 (ja) |
CN (1) | CN101421602B (ja) |
CA (1) | CA2649357C (ja) |
ES (1) | ES2544955T3 (ja) |
RU (1) | RU2391045C1 (ja) |
WO (1) | WO2007123156A1 (ja) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2008065950A1 (en) * | 2006-12-01 | 2008-06-05 | Jms Co., Ltd. | State detecting device |
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Cited By (20)
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WO2008065950A1 (en) * | 2006-12-01 | 2008-06-05 | Jms Co., Ltd. | State detecting device |
US8266967B2 (en) | 2006-12-01 | 2012-09-18 | Jms Co., Ltd. | State detecting device provided in a tube to detect a state of a liquid flowing in the tube |
WO2009072390A1 (ja) * | 2007-12-06 | 2009-06-11 | Asahi Kasei Kuraray Medical Co., Ltd. | 圧力測定部をキャリブレートする方法 |
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JP5230650B2 (ja) * | 2007-12-06 | 2013-07-10 | 旭化成メディカル株式会社 | 圧力測定部をキャリブレートする方法 |
JP2011139647A (ja) * | 2010-01-06 | 2011-07-21 | Shimano Inc | 釣り情報表示装置 |
JP2014190755A (ja) * | 2013-03-26 | 2014-10-06 | Asahi Kasei Medical Co Ltd | 圧力チャンバー |
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JP2017525503A (ja) * | 2014-08-29 | 2017-09-07 | フレゼニウス カービ ドイチュラント ゲーエムベーハー | 血液処理装置において用いるチューブセット |
JP2017529150A (ja) * | 2014-08-29 | 2017-10-05 | フレゼニウス カービ ドイチュラント ゲーエムベーハー | 測定器を備える血液処理装置 |
US10589008B2 (en) | 2014-08-29 | 2020-03-17 | Fresenius Kabi Deutschland Gmbh | Tubing set for use in a blood processing apparatus |
US10898634B2 (en) | 2015-12-14 | 2021-01-26 | Terumo Kabushiki Kaisha | Removable pressure sensor and extracorporeal circulator provided with removable pressure sensor |
US10894143B2 (en) | 2016-01-15 | 2021-01-19 | Terumo Kabushiki Kaisha | Percutaneous catheter and method of using percutaneous catheter |
WO2017212716A1 (ja) | 2016-06-07 | 2017-12-14 | テルモ株式会社 | 経皮カテーテルおよび経皮カテーテル組立体 |
KR20190016492A (ko) | 2016-06-07 | 2019-02-18 | 테루모 가부시키가이샤 | 경피 카테터 및 경피 카테터 조립체 |
WO2018110494A1 (ja) | 2016-12-16 | 2018-06-21 | テルモ株式会社 | カテーテル |
WO2019013089A1 (ja) | 2017-07-10 | 2019-01-17 | テルモ株式会社 | 圧力検知装置および体外循環装置 |
WO2019013088A1 (ja) | 2017-07-10 | 2019-01-17 | テルモ株式会社 | 圧力検知装置および体外循環装置 |
CN109498874A (zh) * | 2018-12-26 | 2019-03-22 | 贝恩医疗设备(广州)有限公司 | 一种用于静脉血液透析的体外循环管路 |
CN109498874B (zh) * | 2018-12-26 | 2023-12-29 | 贝恩医疗设备(广州)有限公司 | 一种用于静脉血液透析的体外循环管路 |
Also Published As
Publication number | Publication date |
---|---|
RU2391045C1 (ru) | 2010-06-10 |
CN101421602A (zh) | 2009-04-29 |
US20090071258A1 (en) | 2009-03-19 |
EP2009415B1 (en) | 2015-07-22 |
EP2009415A4 (en) | 2010-10-13 |
US7748275B2 (en) | 2010-07-06 |
CA2649357C (en) | 2012-12-18 |
ES2544955T3 (es) | 2015-09-07 |
KR101096296B1 (ko) | 2011-12-20 |
EP2009415A1 (en) | 2008-12-31 |
KR20080094682A (ko) | 2008-10-23 |
CA2649357A1 (en) | 2007-11-01 |
CN101421602B (zh) | 2011-02-09 |
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