WO2007104694A1 - Inhalator für pulverförmige substanzen - Google Patents
Inhalator für pulverförmige substanzen Download PDFInfo
- Publication number
- WO2007104694A1 WO2007104694A1 PCT/EP2007/052172 EP2007052172W WO2007104694A1 WO 2007104694 A1 WO2007104694 A1 WO 2007104694A1 EP 2007052172 W EP2007052172 W EP 2007052172W WO 2007104694 A1 WO2007104694 A1 WO 2007104694A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rod
- inhaler
- particular according
- air flow
- flow channel
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0073—Mechanical counters having a display or indicator on a ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/062—Desiccants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
- A61M2205/106—General characteristics of the apparatus with powered movement mechanisms reciprocating
Definitions
- the invention relates to an inhaler for pulverulent substances, in particular medical substances, with a substance storage chamber and a dosing chamber receiving a certain amount thereof, which is designed as a transverse bore of a rod and can be moved from a filling position into an emptying position, in which emptying position the dosing chamber in one Air flow channel lies.
- Inhalers of the type in question are known.
- an inhaler is shown and described which has a rod which has a metering chamber and which can be displaced from a filling position into an emptying position. This shift to the emptying position occurs through a movement that is due to the negative pressure that is generated by the patient's inhalation through the air flow channel.
- the displacement of the dosing chamber and emptying of the dosing chamber is dependent on suction by the patient in the course of deep inhalation.
- the object of the invention is to further improve a generic inhaler in an advantageous manner, in particular with regard to the emptying of the metering chamber in the emptying position.
- Claim 1 solved, it being based on the fact that the rod has a plurality of metering chambers located one behind the other on the rod, which step into the emptying position one after the other during an output operation and can be blown out piece by piece from an air overpressure in the air flow channel. As a result of this configuration, an active emptying of each metering chamber is achieved.
- the Substance delivery is similar to that of inhalers equipped with aerosol cartridges.
- the portioned substance is actively expelled from the dosing chamber by the air overpressure, whereby by arranging a plurality of dosing chambers lying one behind the other, which pass the emptying position one after the other in the course of a displacement of the rod having the dosing chambers in the longitudinal direction thereof, being blown out by machine gun like air. Inhalation of the substance can also be carried out reliably due to the active blowing out of the metering chamber or the metering chambers if, for example, the patient is not able to provide a sufficiently high suction air flow for relocating and emptying only a mostly larger metering chamber, as is known from the prior art known to generate.
- a very fine distribution of the applied substance is achieved through the air pressure blow-out of the dosing chambers, which in turn enables the use of micronized powder substances which are directly accessible to the lungs.
- the metering chambers can also be selected in such a size that approximately 0.03 to 0.2 mg of substance can be taken up in each chamber.
- the suction air flow required for inhaling the substance to be dispensed covers the emptying area of the
- Air flow channel that is, not directly flowed around or through the area penetrated by the rod provided with the metering chambers. Rather, the suction air stream, which is subject to negative pressure, is applied during inhalation only in the region of a mixing section to be assigned to the mouth or nose, into which mixing section the divided substance is actively injected via the excess air pressure.
- the rod is designed as a flat rod with a length measured in cross-section which corresponds to a multiple, for example ten to twenty times the width measured transversely thereto.
- a rod is preferably provided with a thickness of approximately 0.3 to 0.7 mm, preferably 0.5 mm or 0.3 mm.
- the flat bar can consist of a plastic material, in particular a hard plastic material. Preferred is a solution in which the flat bar is made of a metallic material.
- the metering chambers lying one behind the other in the longitudinal extent of the flat bar are provided in the simplest manner as bores in the form of circular disks with a central axis each, which are aligned perpendicular to the flat sides of the flat bar.
- the rod penetrates the substance storage chamber, in particular with the section having the metering chambers, by immersing the powdery substance stored in the storage chamber.
- the pantry wall here preferably consists of an elastic material, for example of a rubber-like material, furthermore of a thermoplastic elastomer.
- this elastically adjusted storage chamber wall is arched in the direction of the rod and thus in the direction of the metering chambers. This is initially done by applying an overpressure acting radially on the outside of the storage chamber wall, which overpressure also serves to empty the metering chambers in the emptying position. This excess pressure is built up in the course of the inhaler actuation, preferably in the form of an excess air pressure.
- the pantry wall bulges at least in the area of the metering hole until it rests on the rod and thus causes the substance stored in the pantry to be pressed into the metering chambers.
- the respective opening cross-sections lie on each side of the flat bar Dosing chambers facing, pantry wall sections.
- the pantry wall sections In this contact position, the pantry wall sections have a wiping effect in the course of a displacement of the rod into the emptying position. Such stripping for exact portioning of the substance to be dispensed is preferably carried out before the emptying position is reached.
- the pantry wall is also actively arched in the direction of the rod.
- pressure pieces are provided which act on the pantry wall from the outside, for the preferred abutment of wall sections on the flat sides of the rod. This active loading of the chamber wall by the pressure pieces further supports the filling of the metering chambers formed in the centrally held rod.
- the displacement of the rod having the metering chamber into the emptying position and the pressurization of the storage chamber wall for filling the metering chambers are carried out in the course of one inhaler actuation.
- an idle stroke is provided between the inhaler actuation button and the rod, which has the effect that, before the rod is taken along, the storage chamber wall is arched by means of the external pressure pieces and, if appropriate, pressurized with air.
- the metering chambers are preferably filled with the pressure pieces with the interposition of the storage chamber wall, preferably still in the rest position of the rod. Only after this filling and the associated end of the empty stroke is the rod dragged along by moving the actuation key to move the dosing chambers into the emptying position.
- the pressure pieces are preferably equipped with jaws which have abutment surfaces which are parallel to the broadside wall surface of the rod in the fully swiveled or pressed position of the pressure pieces, which leads to The correct filling of the dosing chambers results in one. In addition, a stripping position is achieved in this way.
- the cheek-side abutting surfaces are correspondingly flat across a plane.
- the actuation button of the inhaler is formed on the head side of the inhaler housing above this and can be displaced against a return spring.
- the entire inhaler should preferably be grasped between the thumb and middle finger, for example, the middle finger resting on the actuation button and the thumb supporting a housing surface opposite the actuation button.
- the inhaler is actuated by pressing the actuation button, the pressure pieces being pivoted in the direction of the rod via the inclined slopes of the actuation button. After a short idle stroke, the actuation button pushes the rod in front of you, relocating the dosing chambers from the filling position in the storage chamber to the emptying position.
- the run-up bevels of the actuating button have a correspondingly pivoting effect on the latter.
- the pressure pieces can also be arranged such that they can be displaced in a strictly linear manner in the radial direction, this radial displacement towards the rod being achieved by means of a wedge effect.
- the pressure pieces are designed to be self-resetting, in particular in the case of a pivoting configuration thereof, in particular through a corresponding spring characteristic of the arms carrying the pressure pieces. Accordingly, the pressure pieces move back to their original position after releasing the load acting on the run-up bevels, releasing the pantry wall, the latter of which returns to the original position due to the elastic properties.
- the partial relief of the excess air pressure takes place in a staccato-like manner, with the substance being ejected from the respective dosing chamber, which results in an optimal blow-out of the substance and cloud-like output to the Environment as well as the air flow generated by inhalation.
- the excess air pressure to be built up for blowing out is achieved by a piston / housing arrangement.
- This is achieved by an elastic piston ring on the inward end region of the cup-shaped wall of the actuation button, which interacts with an inner wall of the inhaler outer housing, which outer housing correspondingly forms a compressed air cylinder for the piston ring.
- the actuation button itself forms the inside of the piston surface.
- the pressure pieces and the storage chamber are arranged in the region of the compressed air cylinder created in this way, which supports the external loading of the storage chamber and the displacement of the pressure pieces into the metering chamber filling position.
- the linearly displaceable rod which has the metering chambers has a valve character.
- the cross section of the rod closes the air outlet in the region of the air flow channel, according to which, away from the discharge side of the air flow channel, the air overpressure can build up in the course of the downward displacement of the actuation button. Only when a rod dosing chamber is moved into the air flow channel does a valve-like opening and a corresponding compressed air blow-out occur. If the metering chambers are spaced from each other in the direction of travel of the rod, there is always a brief period between the valve ges Closing the flow path through the solid rod material between two metering chambers.
- An air inlet valve is connected between the air outlet closure point, which is formed by the interaction area of the air flow channel and the rod passing through it, and the housing space or compressed air cylinder that receives the storage chamber Allows air to flow into the cylinder chamber, but is closed in the course of an active actuation to dispense an inhalation substance.
- an adjusting device for determining the number of metering chambers which can be brought into the emptying position.
- several, for example three to ten or more, metering chambers, as viewed in the direction of displacement, are provided in the rod, evenly spaced one behind the other.
- a dosage can be selected that limits the longitudinal displacement of the bar.
- only a few or more metering chambers are accordingly moved into the emptying position, that is to say in the area of the compressed air blow-out. Due to the small amounts of substance per dosing chamber, a very precise, variable dosing can be achieved.
- an accessible setting ring is provided, which is provided with several stages, for stopping the sliding movement of the actuation button.
- a certain number of dosing chambers pass through the emptying position.
- the actuation button is provided with countermeasures, so preferably with a stop cam.
- a nozzle-like configuration can be achieved by reducing the cross-section of the air flow channel, in particular of the end section facing the blow-out end. Such a reduced cross section of an air flow channel end section corresponds approximately to 0.5 to 0.9 times the original cross section.
- the rectilinearly directed air flow channel continues into a cross-sectionally smaller, obliquely upward directed end channel section, which ends set back inside a nosepiece to its free end.
- the proposed inhaler can also be used for nasal use. Due to the active emptying of the dosing chambers, the medication to be inhaled is specifically blown out into the nasal cavity. The simultaneous inhalation through the nose advantageously supports the further distribution of the medication.
- the inhaler can be conveniently used, and so on, if necessary, with an approximately vertical alignment of the inhaler axis during the inhalation process.
- a step switch actuated when the blow-out air pressure is reached is provided in a further development of the subject matter of the invention.
- Such a step-by-step mechanism counts every single actuation of the inhaler during which medication is dispensed.
- Such a step-by-step mechanism has a scale, for example a scale ring, on which either the inhalation processes that have already been carried out are displayed or, alternatively, counting down from a maximum number of inhalations to indicate the inhalation shots that are still available.
- the switching mechanism is actuated depending on reaching the blow-out air pressure, which blow-out air pressure immediately before reaching the filled one Dosing chamber is built in the transfer area to the air flow channel.
- the stepping mechanism is switched immediately before the medication is transferred to the air flow channel and accordingly immediately before the medication is actively blown out. If, on the other hand, the handle is only actuated to such an extent that the medication is not imposed, that is, if necessary, only the dosing chambers are filled and the handle is then relocated, the stepping mechanism is not switched.
- this is achieved by a counting finger acting on the indexing mechanism, the tip of which reaches the indexing wheel of the indexing mechanism approximately at the beginning of the displacement of the rod with the filled metering chambers into the area of the air flow channel.
- the counter finger is accordingly positioned at a distance from the indexing wheel, which distance is overcome by manipulating the handle while relocating the rod having the metering chambers and at the same time building up the blow-out air pressure.
- the display of the stepping mechanism is a scale ring which is aligned concentrically with the inhaler axis and which is internally shaped like a ring gear for gradual displacement in the circumferential direction of rotation, for interaction with the stepping wheel.
- the latter is shaped in such a way that it rotates the scale ring of the indexing mechanism in the manner of a worm wheel. Accordingly, no further intermediate gear ratios are required to convert the stepping finger actuation of the stepping wheel from a linear movement into a circular movement directed transversely to the axis.
- the transmission to the scale ring, in particular the stepping mechanism can be under or translated.
- FIG. 2 shows a sectional illustration corresponding to FIG. 1, but after removing a mouthpiece protective cap, relating to a first intermediate position in the course of actuation of the inhaler, in which dosing chambers are filled with the substance;
- Figure 4 shows the section along the line IV - IV in Fig. 3.
- FIG. 5 shows a follow-up view of FIG. 2, after a further shift in actuation and substance delivery;
- FIG. 7 shows a follow-up view of FIG. 5, relating to an intermediate position in the course of the relocation
- FIG. 8 shows a perspective individual illustration of a holder with a storage chamber and pressure pieces attached to it, as well as a rod having metering chambers and a return coil spring;
- FIG. 9 shows an illustration based on FIG. 8, but in an exploded illustration
- 10 is a perspective view of the inhaler in a second embodiment
- FIG. 11 shows the inhaler according to FIG. 10 in a partial exploded view
- FIG. 12 shows a vertical sectional view corresponding to FIG. 1, relating to the inhaler in a further embodiment for nasal inhalation;
- FIG. 13 shows the inhaler in a vertical sectional view in a further embodiment with a step-by-step mechanism relating to the basic position
- FIG. 14 the area XIV in FIG. 13 in an enlarged representation
- FIG. 15 shows a representation essentially corresponding to FIG. 14, but in an actuation position of the inhaler in which the stepping mechanism is actuated by a counter finger;
- FIG. 16 shows a perspective partial sectional view according to FIG. 15;
- FIG. 17 shows the section along the line XVII - XVII in FIG. 15;
- Fig. 18 shows the stepping wheel of the stepping mechanism in a single side view
- Fig. 19 the stepping wheel in perspective individual representation.
- An inhaler 1 is shown and described, which is realized as a pocket device that can be carried comfortably, with a cylindrical housing 2, of which an approximately radially protruding mouthpiece 3 starts.
- the general shape of the inhaler 1 essentially corresponds to that of the inhalers provided with aerosol cartridges. Accordingly, the mode of action of the inhaler 1 is also transferred and immediately recognizable for the user.
- the inhaler 1 thus has an actuating button 4 which receives the general housing axis x, is oriented transversely to this axis x and projects beyond the housing 2 and which is opposed by a counter surface 5 on the housing foot side. Dispensing the actuating button 4 in the direction of the counter surface 5 on the underside along the axis x achieves substance delivery.
- the housing 2 is formed in the form of a hollow cylindrical body, with a circular plan in the exemplary embodiment shown.
- Other shapes deviating from this circular plan shape are also conceivable, for example elliptical or polygonal shapes.
- the circular cylindrical inhaler outer housing 6 is closed on the foot side by an inhaler base 7, which forms the counter surface 5 for actuating the inhaler 1. To the bottom 7 opposite side, the housing 2 is open.
- the mouthpiece 3 which is essentially designed as a hollow cylinder body, grows out of the housing 2 approximately in a radial orientation, specifically in the exemplary embodiment shown, including an acute angle of approximately 75 to 80 ° to the inhaler axis x. with a mouth pointing axially outwards with respect to the orientation of the mouthpiece 3.
- a mouthpiece bottom 8 arranged in the transition area from the housing 2 into the mouthpiece 3 has a central opening 9. At an axial distance from this central bottom opening 9, air inflow openings 10 are formed in the mouthpiece wall along a circumferential line, for the air flow connection of the interior of the mouthpiece assigned to the bottom opening 9 to the surroundings.
- the mouthpiece 3 is covered by a screw cap 11 when the inhaler 1 is not in use.
- the mouthpiece 3 is provided with an outer thread 12 on the outer jacket surface, which cooperates with an inner thread 13 of the cap 11.
- the jacket section of the screw cap 11, which has the internal thread 13, extends over the air inflow openings 10 of the mouthpiece 3 in the closed position, the end ring surface of this jacket section of the screw cap 11 also coming into contact with a housing section in a limited manner.
- the housing 2 is divided transversely to the housing axis x by a carrier 14 fastened to the housing inner wall at the level of the transition from the housing to the mouthpiece 3. Accordingly, there is an upper housing section with reference to the carrier 14 and a lower section assigned to the counter surface 5, which is penetrated centrally by a support tube 15, which extends in the axial direction and on which the support 14 is seated.
- a moisture-absorbing material 16 is accommodated in the annular space created in this way in the lower housing section.
- this annular space 17 is connected to the cylinder interior of the mouthpiece 3 via an afterflow opening 18, which is formed in the region of the mouthpiece bottom 8, and to the surroundings via the air inflow openings 10.
- the disk-shaped, solid support 14 has a central receptacle 19, into which a sealing element 20 made of a thermoplastic material is inserted.
- This sealing element 20 is plug-like in the receptacle 19, the carrier 14 also being supported on the pipe 15 via this sealing element 20.
- the sealing element 20 is provided with an air flow channel 21, which is aligned essentially in a straight line transversely to the axis x and is continued on both sides, penetrating the carrier 14 in each case.
- the air flow channel 21 on the one hand of the sealing element 20 extends through the carrier 14 through to the central opening 9 of the mouthpiece bottom 8, to form an air outlet 22.
- the air flow channel 21 extends with an enlarged cross section towards the upper housing section separated by the carrier 14.
- the corresponding channel opening 23 is formed on the broad surface of the carrier 14 facing the upper housing section, this channel opening 23 also being covered by a filter element 24.
- the air flow channel 21 is thus subdivided into a channel section on the mouthpiece side and a section on the housing side.
- the filter-covered channel mouth 23 is formed.
- an afterflow opening 25 opposite the channel opening 23 is arranged, which forms a connection between the section of the air flow channel 21 on the housing side and the annular space 17 formed on the underside of the carrier 14.
- This inflow opening 25 is overlaid by an air inlet valve 26, which is switched such that the inflow opening 25 is opened only in the case of an air flow from the annular space 17 through the air flow channel 21 in the direction of the upper housing section. In the opposite direction of air flow, the valve 26 closes this afterflow opening 25.
- the air flow channel 21, in particular in the area of the sealing element 20 and of the section facing the mouthpiece 3, is dimensioned substantially smaller than the free cross section of the mouthpiece 3.
- the free interior diameter of the mouthpiece 3 corresponds approximately to ten to thirty times the diameter of the air flow channel 21, which the latter in particular is formed tapering from the sealing element 20 in the direction of the mouthpiece-side opening 9 in the region of an obliquely downward section, for the formation of a nozzle-like channel.
- the sealing element 20 merges in one piece, in the same material, into a funnel-shaped storage chamber 27 facing the upper housing section, with the cross-section widening in the direction of the front housing opening.
- the pantry wall 28 accordingly also consists of a thermoplastic elastomer or another rubber-like material.
- the diameter-widened free end of the storage chamber 27 is gripped by a holder 29 oriented transversely to the inhaler axis x, which is fastened to the support 14 which holds the lower end of the storage chamber 27 by means of supports 30 which extend laterally to the storage chamber and are arranged opposite one another.
- the axial distance between the ends of the pantry is fixed accordingly.
- the upper free end of the storage chamber 27 is sealed in the holder 29, so in the exemplary embodiment shown it is clamped between a radially outer retaining ring 31 and a radially inner, plug-like holding section 32.
- a micronized powdery substance 33 is stored in the storage chamber 27 and is to be inhaled in portioned form by means of the proposed device.
- Metering chambers 34 are provided for portioned delivery of substance 33, three of which are shown in the first embodiment shown.
- the size of a Each dosing chamber 34 defines the amount of substance to be discharged.
- the metering chambers 34 are designed as transverse bores 35 of a rod 36 which is formed as a flat rod and extends centrally along the axis x.
- the transverse bores 35 penetrate the broad side wall surfaces of the flat bar 36, this further having a width / length ratio of 1: 5 to 1:20 in cross section.
- a flat bar thickness of approximately 0.5 mm is selected, with a length of approximately 3 to 3.5 mm measured transversely thereto.
- the diameter of the transverse bores 35 is selected such that each metering chamber 34 thus formed receives a quantity of substance from 0.05 mg to 0.1 mg.
- the rod 36 with the metering chambers 34 passes through the storage chamber 27 centrally in the direction of extension of the axis x. On the foot side of the storage chamber 27, the rod 36 continues to pass through the sealing element 20 while crossing the air flow channel 21 formed therein, according to this embodiment, the air flow channel 21 is initially closed by means of the rod 36.
- the rod 36 extends beyond the storage chamber 27, with the penetration of the holder 29 defining the storage chamber 27.
- a further sealing element 37 is arranged in the enforcement area of the holder 29, which, like the sealing element 20, is located in the foot-side region of the storage chamber 27 stripping on the surfaces of the rod 36, while sealing the enforcement zones.
- the metering chambers 34 which are uniformly spaced apart from one another in the longitudinal extension of the rod 36, are positioned in the lower third of the storage chamber 27, enclosed by the stored substance 33.
- the distance between the metering chambers 34 essentially corresponds to the diameter of a transverse bore 35 forming a metering chamber 34.
- the free end of the rod 36 which projects upward beyond the storage chamber 27 is provided with a mushroom-shaped driver 38.
- This is detected by the towing arms 39 formed on the underside of the actuation button 4, which have a length that corresponds approximately to twice the length of the driver 38 in the direction of extension of the axis x.
- An idle stroke is thus created between the tip of the driver 38 facing the operating button 4 and the driving surface 40 of the operating button 4 on the underside corresponding thereto.
- the actuation button 4 which extends essentially transversely to the inhaler axis x, merges into a cylindrical section which is formed concentrically to the axis x and has a cup-shaped wall 41 which, with its opening pointing downward, dips into the housing 2.
- the outside diameter of the wall 41 is correspondingly adapted to the inside diameter of the housing-cylinder section 6.
- the actuation button 4 can be inserted with its wall 41 into the housing 2 under guidance by the cylinder section 6, this with limit stop in the respective end positions.
- the housing-cylinder section 6 has in the area of its free edge section two diametrically opposed, radially inward guide lugs 42 which engage in axially parallel grooves 43 in the area of the outer casing of the wall 41. This also ensures that the housing 2 and the actuation button 4 are secured against rotation.
- an annular groove 44 is provided on the outer surface of the jacket, for receiving a piston ring 45 made of an elastomer material, which seals against the inner wall of the housing cylinder section 6.
- the actuation key basic position as shown in FIG. 1 is supported by a return coil spring 46 acting on the underside of the actuation key 4, which supports the rod 36 and the trailing arms 39 of the actuation key 4 on the holder 29 forming the head end of the storage chamber 27.
- This basic position is defined by striking the guide lugs 42 at the lower end of the grooves 43 on the actuating key side, furthermore in this basic position the rod-side driver 38 assumes a maximum distance from the driving surface 40 of the actuating button 4.
- These arms 49 provided with thrust pieces 48 are referenced positioned on a floor plan offset by 90 ° to the supports 30 carrying the holder 29; further attached to the holder 2 via a circular ring-shaped carrier in plan.
- the arms 49 and the radially inward facing abutment surfaces 50 of the jaws 60 forming pressure pieces 48 extend in a plan view or in a cross section through the inhaler 1 parallel to a broad side surface of the rod 36.
- the abutment surfaces 50 are the broad side surfaces of the rod 36 positioned facing, the abutment surfaces 50 are each formed flat.
- the arms 49, and in particular the articulation areas 51 on the annular carrier are selected with regard to the choice of material and / or with regard to the material thickness such that radial articulation in the direction of the axis x is permitted around the articulation areas 51.
- the spring properties of the selected plastic material are used for the automatic return of the arms 49 to the original position.
- the length of the arms 49 measured in the axial direction is selected such that the pressure pieces 48 provided at the end extend approximately at the level of the lower third of the storage chamber 27.
- the inhaler 1 works as follows:
- the actuation button 4 By pressing (represented by the arrow P) on the actuation button 4, the latter is lowered into the housing 2 along the x axis. Housing 2 and due to the seal via the piston ring 45, the pot-like actuation button 4 form a compressed air cylinder D, in which an air overpressure is built up in the course of the lowering of the actuation button 4. The inner underside of the actuation button 4 forms the piston surface.
- the disengaging projections 47 are acted upon via the end edge of the wall 41 provided with a corresponding chamfer, which, with the button 4 being lowered further, causes the arms 49 to pivot in about the articulation areas 51.
- the pressing pieces 48 pivot radially inward by a radius to the articulation areas 51, arching the storage chamber wall 28 into the filling position B as shown in FIG. 2, in which the abutting surfaces 50 are parallel to one another and to the broad side surfaces of the rod 36 reach in which position substance portions into the metering chambers 34 with the intermediate storage chamber wall sections in between are pressed.
- the substance present in the basic position of the inhaler 1 on both sides of the metering chamber openings is forced into the transverse bores 35 by means of the storage chamber wall 28 and the pressure pieces 48 acting thereon, after which self-retention is given in the metering chambers 34, in particular in the case of a micronized powder substance.
- the rod 36 remains in its basic position until the metering chambers 34 are completely filled, due to the idle stroke provided in the area of the drag arms 39. Only after this dosing chamber filling does the driving surface 40 formed on the underside of the button come against the driver 38 on the rod end, in order to carry the rod 36 with it when the actuating button 4 is moved further downward.
- the filled metering chambers 34 successively overlap the air flow channel 21, which until then has been closed in a slide-like manner by the closed, solid end section of the rod 36, which enables the pressure to be built up. If a metering chamber 34 reaches the air flow channel 21 (emptying position E), the valve thus created is opened briefly. The transverse bore 35 forming the dosing chamber 34 becomes part of the air flow channel 21.
- the built-up air pressure causes the portioned substance to be suddenly blown out of the dosing chamber to inject this portion into the mouthpiece 3 via the air outlet 22, the latter when the inhaler 1 is actuated by The lips are enclosed in such a way that the air inflow openings 10 are not covered. Inhaling is about this Air inlet openings 10 sucked in ambient air, which is enriched with the injected portioned substance cloud.
- the end position of the actuation button 4 considered in the downward displacement direction is also stop-limited. This by striking the guide lugs 42 against the upper edge region of the grooves 43 interacting with them and / or by stepping the free annular end face of the actuation button wall 41 against the surface of the carrier 14.
- the rod 36 can also consist of such a hard plastic material. In this regard, however, a rod 36 made of a metal material is preferred.
- inhaler 1 shaped for oral treatment is also conceivable in a version for nasal inhalation. As shown, for example, in FIG. 12.
- the discharge or ejection region is directed obliquely upwards with respect to the vertical axis x, thus including an angle to the longitudinal axis x of approximately 45 °.
- the housing 2 is provided with a nosepiece 65 which, when the inhaler 1 is not used, is covered by a screw cap 11 in accordance with the previously described embodiment.
- the nosepiece 65 is adapted in its longitudinal extent and in its outer diameter for insertion into a nostril. Centrally in the longitudinal extent of the nosepiece 65 is penetrated by an outlet channel 66. In an end channel section 67 of the air flow channel 21 opens out, the free end 68 of which is set back, correspondingly axially displaced with respect to the nasal sleeve body axis to the free end 69 of the nasal sleeve 65.
- the end channel section 67 also runs obliquely upward, starting from the transversely directed straight air flow channel 21, while reducing the free cross section by approximately the cross section of the air flow channel 21 one third, which allows a nozzle-like configuration of the end channel section 67.
- FIGS. 10 and 11 show a second embodiment, relating to an inhaler 1 with a dosage setting.
- a ring-like adjusting device 52 is provided, which encloses the housing 2 in the upper edge area facing the actuation button 4. Its setting ring 62 can be rotated coaxially to the axis x about it in stages, for example via four rotary locking stages for setting five different dosages.
- the ring-shaped adjusting device 52 is provided with step bodies 53 arranged diametrically opposite one another, which are designed to penetrate windows 54 of the housing 2 that protrude radially inwards.
- Each step body 53 is provided with stop surfaces 55 which are offset in steps from one another. The number of step surfaces corresponds to the number of dosing settings.
- These stop surfaces 55 act together with correspondingly diametrically opposed cams 56 arranged on the outer jacket of the wall 41. These are guided in correspondingly positioned grooves 57 on the inside of the wall of the housing cylinder section 6 and secured against rotation relative to the housing 2.
- a cam surface 58 which points downward in the pushing-in direction of the actuating key 4, acts upon actuation against the stop surface 55 of the step body 53 which is screwed into the displacement path of the cam 56, with which the displacement movement of the actuating key 4 is stopped.
- Rods 36 stop-limited, according to which, depending on the setting via the step stops, the number of metering chambers 34 to be brought into the emptying position E can be preselected.
- the inhaler 1 when the inhaler 1 is actuated, for example, only two metering chambers 34 or only the first metering chamber 34 can be connected to the air flow channel 21 and can be blown out by means of pressurized air.
- all metering chambers 34 such as five metering chambers 34 as shown, can be fed to the air flow channel 21 one after the other and their substance portions can be poured out like a salvo.
- FIGS. 13 to 19 show, in a further embodiment, an inhaler 1 which is initially designed as an oral inhaler according to the first embodiment.
- a step switch 70 is provided for registration and Display of the inhalation processes carried out.
- This step-by-step mechanism 70 is arranged in the actuation button 4 protruding above the housing 2, so further immediately below the ceiling of the actuation button 4, surrounding the trailing arms 39 interacting with the driver 38 of the rod 36.
- the indexing mechanism 70 essentially consists of an indexing wheel 71 and a scale ring 72 which is in positive engagement with the indexing wheel 71.
- the scale ring 72 is arranged like a cuff directly underneath the actuating cover, so concentric to the housing axis x.
- the circumferential scale ring wall lies in a radial enlargement of the wall 41 of the actuation button 4, a rotation about the housing axis x is accordingly held in this radial receptacle 73 of the wall 41.
- the scale ring 72 is provided with a scale 74 (not shown in more detail), for example printed with one.
- This scale 64 is visible through a window 75 provided on the wall side in a transition region from the wall 41 into the ceiling of the actuation button 4.
- entraining projections 76 projecting radially inwards in the middle of the vertical extent.
- a plurality of such entrainment projections 76 are provided while maintaining uniform distances from one another, for example a number which corresponds to the maximum number of inhalation triggers. In the illustrated embodiment, however, a much smaller number is chosen.
- the entrainment of the scale ring 72 via the projections 76 is stepped down here.
- the stepping wheel 71 interacts positively with these driving projections 76, the stepping wheel 71 being transversely to the housing axis x aligned axis of rotation y is rotatable, which axis y extends in the plane spanned by the driving projections 76.
- the axis y is solved by an axle body 77, which is mounted on both ends in mounting arms 78 which protrude inwards from the actuating button cover.
- the indexing gear 71 is essentially designed as a single-start worm shaft 79 with a worm helix pitch that is adapted to the spacing between two adjacent entrainment projections 76 in the circumferential direction.
- the worm shaft 79 is provided with such a length that a total of two to three worm helix sections result essentially.
- the associated driving projection 76 occurs at the level of the indexing wheel 71 between the flanks of the screw helix.
- the circumferential end edge of the worm helix is sawtooth-shaped, each tooth 80 having a steep flank that is oriented approximately to a radial and backwards a flank that slopes flatly toward the following tooth 80.
- nine teeth 80 are formed over the circumference in cross section through the stepping wheel 71, which are further dimensioned such that in a transverse view, i. H. viewed in the alignment of the axis y, the teeth 80 of a helical section lie in a horizontal projection in overlap with the teeth 80 of the adjacent helical section.
- the respective tooth flanks of adjacent spiral sections are also aligned in a common plane.
- the teeth 80 cooperate with a counting finger 81 which, viewed parallel to the axis of rotation y of the indexing wheel 71, in the free end region, that is in the actuating end section 82 cooperating with the stepping wheel 71 has a width which corresponds approximately to the width of the stepping wheel 71 measured in the same direction.
- the counting finger 81 is rooted in the annular support carrying the arms 49 of the pressure pieces 48 and grows out like a rod with parallel alignment to the housing axis x upwards in the direction of the stepping wheel 71 which is vertically spaced apart in the basic position as shown in FIG. 13, this taking the end shape of the above, a tip-forming operation portion 82.
- the vertical distance between the actuating section 82 of the counting finger 81 and the steep flank to be actuated of a tooth 80 of the stepping wheel 71 pointing radially inward is corresponding to the stroke of the actuating button 4, starting from the basic position in FIG. 13 to the transfer position of the medicament from the filled one Dosing chamber 34 selected in the air flow channel 21 as shown in Figure 5 or Figure 6.
- the step-by-step mechanism 70 is only actuated, that is to say switched one position further, when the metering chambers 34 are first filled via the pressure pieces 48 in the course of the downward displacement of the actuating button 4 and then, with further downward displacement of the actuating button 4, for the sudden blowing out of the metering chambers 34 required air pressure is reached.
- the inhaler can contain various drugs and / or bioactive substances for inhalation.
- bioactive substance is any therapeutic or diagnostic agent can be selected for example from the group of antiallergics, bronchodilators, bronchoconstrictors, Lachesurfaktantien, analgesics, antibiotics, leukotriene inhibitors or antagonists, anticholinergics, mast cell inhibitors, antihistamines, antiinflammatories, antineoplastics, arrival ⁇ sthetika, antimycobacterial , Contrast media, cardiovascular agents, enzymes, steroids, genetic material, virus vectors, counter-strand reagents, proteins or peptides and combinations of these substances.
- Examples of specific pharmaceuticals with which the inhaler can be filled according to the patent specification include a. Mometasone, ipratropium bromide, tiotropium and its salts, salmeterol, fluticasone propionate, beclomethasone dipropionate, reproterol, clenbuterol, rofleponide and salts, nedocromil, sodium cromoglycate, flunisolide, budesonide, formoterol fumarate dihydrate, Symbicort® (budesonide and formoterol), terbutaline, terbutaline sulphate, Salbu- tamol base and sulfate, fenoterol, 3- [2- (4-hydroxy-2-oxo-3H-l, 3-benzothiazol-7-yl) ethylamine] -N- [2- [2- (4-methylphenyl) ethoxy ] ethyl] propanesulfonamide, hydrochlor
- Drug combinations can also be used, for example formoterol / budesonide; Formoterol / fluticasone; Formoterol / mometasone; Salmeterol / fluticasone; Formoterol / tiotropium salts; Zaf irlukast / formoterol, Zaf irlukast / budesonide; Montelukast / formoterol; Montelukast / budesonide; Loratadin / Montelukast and Loratadin / Zaf irlukast.
- Tiotropium and fluticasone Tiotropium and fluticasone, tiotropium and budesonide, tiotropium and mometasone, mometasone and salmeterol, formoterol and rofleponide, salmeterol and budesonide, salmeterol and rofleponide as well as tiotropium and rofleponide.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Centrifugal Separators (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK07726709.4T DK1993644T3 (da) | 2006-03-10 | 2007-03-08 | Inhalator til pulverformige substanser |
JP2008557759A JP2009529360A (ja) | 2006-03-10 | 2007-03-08 | 粉状物質用吸入器 |
MX2008011620A MX2008011620A (es) | 2006-03-10 | 2007-03-08 | Inhalador para sustancias pulverulentas. |
US12/224,473 US8261737B2 (en) | 2006-03-10 | 2007-03-08 | Inhaler for powdery substances |
CA002645262A CA2645262A1 (en) | 2006-03-10 | 2007-03-08 | Inhalator for powdery substances |
AU2007224521A AU2007224521A1 (en) | 2006-03-10 | 2007-03-08 | Inhalator for powdery substances |
EP07726709A EP1993644B1 (de) | 2006-03-10 | 2007-03-08 | Inhalator für pulverförmige substanzen |
ES07726709T ES2384648T3 (es) | 2006-03-10 | 2007-03-08 | Inhalador para sustancias en polvo |
BRPI0708759-4A BRPI0708759A2 (pt) | 2006-03-10 | 2007-03-08 | inalador para substÂncias em pà |
IL193562A IL193562A0 (en) | 2006-03-10 | 2008-08-20 | Inhalator for powdery substances |
NO20084250A NO20084250L (no) | 2006-03-10 | 2008-10-10 | Inhalator for puddersubstanser |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006011559.7 | 2006-03-10 | ||
DE102006011559 | 2006-03-10 | ||
DE102006029753.9 | 2006-06-27 | ||
DE102006029753A DE102006029753A1 (de) | 2006-03-10 | 2006-06-27 | Inhalator für pulverförmige Substanzen |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007104694A1 true WO2007104694A1 (de) | 2007-09-20 |
Family
ID=38038677
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/052172 WO2007104694A1 (de) | 2006-03-10 | 2007-03-08 | Inhalator für pulverförmige substanzen |
PCT/EP2007/052178 WO2007104698A1 (de) | 2006-03-10 | 2007-03-08 | Inhalator für pulverförmige substanzen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/052178 WO2007104698A1 (de) | 2006-03-10 | 2007-03-08 | Inhalator für pulverförmige substanzen |
Country Status (15)
Country | Link |
---|---|
US (2) | US8261737B2 (de) |
EP (2) | EP1993643B1 (de) |
JP (2) | JP2009529361A (de) |
KR (2) | KR20080099856A (de) |
AT (1) | ATE541603T1 (de) |
AU (2) | AU2007224521A1 (de) |
BR (2) | BRPI0708759A2 (de) |
CA (2) | CA2645262A1 (de) |
DE (1) | DE102006029753A1 (de) |
DK (2) | DK1993644T3 (de) |
ES (2) | ES2379112T3 (de) |
IL (2) | IL193561A0 (de) |
MX (2) | MX2008011621A (de) |
NO (2) | NO20084251L (de) |
WO (2) | WO2007104694A1 (de) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101925376B (zh) * | 2007-11-22 | 2013-07-10 | 赛诺菲股份有限公司 | 用于吸入粉末状物质的定量装置 |
WO2015169429A2 (en) | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Container, indicator device, and nebulizer |
DE102014118325A1 (de) | 2014-12-10 | 2016-06-16 | Alfred Von Schuckmann | Zählwerk |
DE102016106875A1 (de) | 2016-04-13 | 2017-10-19 | Alfred Von Schuckmann | Handgerät zur Ausgabe einer pharmazeutischen Substanz sowie Zählwerk für ein solches Handgerät |
US10716905B2 (en) | 2014-02-23 | 2020-07-21 | Boehringer Lngelheim International Gmbh | Container, nebulizer and use |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0625303D0 (en) * | 2006-12-19 | 2007-01-24 | Jagotec Ag | Improvements in and relating to metered dose inhalers |
DE102007017725A1 (de) | 2007-04-16 | 2008-10-23 | Astrazeneca Ab | Inhalator für pulverförmige Substanzen |
DE102007017724A1 (de) * | 2007-04-16 | 2008-10-23 | Astrazeneca Ab | Inhalator für pulverförmige Substanzen |
WO2009029029A1 (en) * | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | Inhaler for powdered substances with desiccant compartment |
WO2009029028A1 (en) * | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | Breath- triggered inhaler with dose counter |
DE102007053590A1 (de) | 2007-11-09 | 2009-05-14 | Astra Zeneca Ab | Handgerät zum Inhalieren von Substanzen |
EP2534958A1 (de) | 2007-12-14 | 2012-12-19 | AeroDesigns, Inc | Abgabe von Aerosol-sprühbaren Nahrungsmittelprodukten |
GB0800457D0 (en) * | 2008-01-11 | 2008-02-20 | Innovata Biomed Ltd | Improvements in or relating to inhalers |
GB0800459D0 (en) * | 2008-01-11 | 2008-02-20 | Innovata Biomed Ltd | Improvements in or relating to inhalers |
GB0920499D0 (en) | 2009-11-23 | 2010-01-06 | 3M Innovative Properties Co | Dose counter |
US9750901B2 (en) * | 2011-06-13 | 2017-09-05 | Shanghai Xiuxin Chenpon Pharmaceutical Technology Co., Ltd. | Dry powder drug-dosing device |
CN104203319B (zh) * | 2012-01-23 | 2017-03-08 | 赛诺菲股份有限公司 | 用于吸入装置的剂量计数机构和吸入装置 |
US20150202392A1 (en) * | 2012-07-20 | 2015-07-23 | Sanofi Sa | Metering element for an inhalation device and inhalation device comprising a metering element |
DE102012107767A1 (de) * | 2012-08-23 | 2014-02-27 | Rpc Formatec Gmbh | Verfahren zum Entleeren einer Kavität und Vorrichtung zum Entleeren einer Kavität |
US20150297842A1 (en) * | 2012-11-12 | 2015-10-22 | Sanofi Sa | Assembly for an Inhalation Device and Use of a Sealing Member |
US8920364B2 (en) | 2013-02-28 | 2014-12-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
US8845578B2 (en) | 2013-02-28 | 2014-09-30 | Medtronic Xomed, Inc. | Biomaterial delivery device |
AR095222A1 (es) * | 2013-04-03 | 2015-09-30 | Sanofi Sa | Elemento de medición para un dispositivo de inhalación y montaje para un dispositivo de inhalación que comprende un elemento de medición |
CN108744187A (zh) * | 2015-05-16 | 2018-11-06 | 苏州汉方医药有限公司 | 由手动悬浮微颗粒发生器和刺五加或刺五加总皂组成的药盒 |
DE102015119617A1 (de) | 2015-11-13 | 2017-05-18 | Alfred Von Schuckmann | Handbetätigbarer Inhalator |
DE102015120949A1 (de) * | 2015-12-02 | 2017-06-08 | Alfred Von Schuckmann | Inhalator für pulverförmige Substanzen sowie Zählwerk für einen Inhalator |
DE102015120948A1 (de) * | 2015-12-02 | 2017-06-08 | Alfred Von Schuckmann | Handgerät zur Ausgabe einer pharmazeutischen Substanz sowie Zählwerk und Schraubkappe für ein solches Handgerät |
IL273713B2 (en) | 2017-10-09 | 2023-10-01 | Pearl Therapeutics Inc | Drug administration systems and related methods |
EA039533B1 (ru) * | 2018-03-07 | 2022-02-08 | Перл Терапьютикс, Инк. | Устройство для доставки лекарств |
EP4371555A3 (de) | 2020-05-14 | 2024-07-24 | Eli Lilly and Company | Nasale verabreichungsvorrichtung |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993016748A2 (en) * | 1992-02-21 | 1993-09-02 | Innovata Biomed Limited | Metering device |
WO2000064519A1 (en) * | 1999-04-23 | 2000-11-02 | Orion Corporation | Powder inhaler for combined medicament |
WO2001021238A2 (en) * | 1999-09-17 | 2001-03-29 | Orion Corporation | Moisture protected powder inhaler |
WO2005016424A2 (en) * | 2003-02-20 | 2005-02-24 | Ivax Corporation | Pre-metered dose magazine for dry powder inhaler |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE758834A (fr) | 1969-11-13 | 1971-05-12 | Riker Laboratoires Inc | Distributeur d'aerosol actionne par inhalation |
US5113855A (en) | 1990-02-14 | 1992-05-19 | Newhouse Michael T | Powder inhaler |
DE4027391A1 (de) | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | Treibgasfreies inhalationsgeraet |
US5429122A (en) | 1990-09-26 | 1995-07-04 | Zanen; Pieter | Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber |
US5243970A (en) | 1991-04-15 | 1993-09-14 | Schering Corporation | Dosing device for administering metered amounts of powdered medicaments to patients |
FR2676929B1 (fr) * | 1991-05-30 | 1994-02-11 | Aerosols Bouchage Ste Fse | Inhalateur de poudres. |
AU651910B2 (en) | 1991-08-15 | 1994-08-04 | Franco Del Bon | Inhaler |
US5896855A (en) * | 1992-12-24 | 1999-04-27 | Rhone-Poulenc Rorer Limited | Multi dose inhaler apparatus |
US5524613A (en) | 1993-08-25 | 1996-06-11 | Habley Medical Technology Corporation | Controlled multi-pharmaceutical inhaler |
NZ277290A (en) * | 1993-12-18 | 1998-03-25 | Merck Patent Gmbh | Replacement cartridge for a powder inhalator has doses dispensed from helically arranged compartments |
US7131441B1 (en) * | 1995-12-07 | 2006-11-07 | Skyepharma Ag | Inhaler for multiple dosed administration of a pharmacological dry powder |
US6926003B2 (en) | 1999-12-07 | 2005-08-09 | Orion Corporation | Multidose powder inhaler |
DE10106788A1 (de) | 2001-02-12 | 2002-08-14 | Schuckmann Alfred Von | Inhalator für pulverförmige, insbesondere medizinische Substanzen |
GB0111336D0 (en) | 2001-05-10 | 2001-07-04 | Innovata Biomed Ltd | Device |
SE0101825D0 (sv) | 2001-05-22 | 2001-05-22 | Astrazeneca Ab | An Inhalation device |
EP1539286B1 (de) | 2002-09-16 | 2015-01-21 | Sanofi SA | Inhalator für pulverförmige, insbesondere medizinische substanzen |
US7600512B2 (en) | 2003-07-14 | 2009-10-13 | Vortran Medical Technology 1, Inc. | Inhaler with breath actuated dose counter |
DE102005033397A1 (de) | 2005-07-18 | 2007-01-25 | Alfred Von Schuckmann | Inhalator für pulverförmige, insbesondere medizinische Substanzen |
-
2006
- 2006-06-27 DE DE102006029753A patent/DE102006029753A1/de not_active Withdrawn
-
2007
- 2007-03-08 US US12/224,473 patent/US8261737B2/en not_active Expired - Fee Related
- 2007-03-08 BR BRPI0708759-4A patent/BRPI0708759A2/pt not_active Application Discontinuation
- 2007-03-08 ES ES07712486T patent/ES2379112T3/es active Active
- 2007-03-08 US US12/224,462 patent/US8132565B2/en not_active Expired - Fee Related
- 2007-03-08 AU AU2007224521A patent/AU2007224521A1/en not_active Abandoned
- 2007-03-08 DK DK07726709.4T patent/DK1993644T3/da active
- 2007-03-08 EP EP07712486A patent/EP1993643B1/de not_active Not-in-force
- 2007-03-08 AT AT07712486T patent/ATE541603T1/de active
- 2007-03-08 DK DK07712486.5T patent/DK1993643T3/da active
- 2007-03-08 JP JP2008557760A patent/JP2009529361A/ja not_active Withdrawn
- 2007-03-08 ES ES07726709T patent/ES2384648T3/es active Active
- 2007-03-08 JP JP2008557759A patent/JP2009529360A/ja not_active Withdrawn
- 2007-03-08 MX MX2008011621A patent/MX2008011621A/es not_active Application Discontinuation
- 2007-03-08 AU AU2007224525A patent/AU2007224525A1/en not_active Abandoned
- 2007-03-08 WO PCT/EP2007/052172 patent/WO2007104694A1/de active Application Filing
- 2007-03-08 EP EP07726709A patent/EP1993644B1/de not_active Not-in-force
- 2007-03-08 MX MX2008011620A patent/MX2008011620A/es not_active Application Discontinuation
- 2007-03-08 BR BRPI0708741-1A patent/BRPI0708741A2/pt not_active Application Discontinuation
- 2007-03-08 KR KR1020087021266A patent/KR20080099856A/ko not_active Application Discontinuation
- 2007-03-08 CA CA002645262A patent/CA2645262A1/en not_active Abandoned
- 2007-03-08 WO PCT/EP2007/052178 patent/WO2007104698A1/de active Application Filing
- 2007-03-08 CA CA002645276A patent/CA2645276A1/en not_active Abandoned
- 2007-03-08 KR KR1020087021265A patent/KR20080103060A/ko not_active Application Discontinuation
-
2008
- 2008-08-20 IL IL193561A patent/IL193561A0/en unknown
- 2008-08-20 IL IL193562A patent/IL193562A0/en unknown
- 2008-10-10 NO NO20084251A patent/NO20084251L/no unknown
- 2008-10-10 NO NO20084250A patent/NO20084250L/no not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993016748A2 (en) * | 1992-02-21 | 1993-09-02 | Innovata Biomed Limited | Metering device |
WO2000064519A1 (en) * | 1999-04-23 | 2000-11-02 | Orion Corporation | Powder inhaler for combined medicament |
WO2001021238A2 (en) * | 1999-09-17 | 2001-03-29 | Orion Corporation | Moisture protected powder inhaler |
WO2005016424A2 (en) * | 2003-02-20 | 2005-02-24 | Ivax Corporation | Pre-metered dose magazine for dry powder inhaler |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9895501B2 (en) | 2007-11-22 | 2018-02-20 | Sanofi-Aventis Deutschland Gmbh | Metering device for the inhalation of a pulverulent substance |
US8573204B2 (en) | 2007-11-22 | 2013-11-05 | Siegfried Generics International | Metering device for the inhalation of a pulverulent substance |
CN101925376B (zh) * | 2007-11-22 | 2013-07-10 | 赛诺菲股份有限公司 | 用于吸入粉末状物质的定量装置 |
US10716905B2 (en) | 2014-02-23 | 2020-07-21 | Boehringer Lngelheim International Gmbh | Container, nebulizer and use |
US10716907B2 (en) | 2014-05-07 | 2020-07-21 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10576222B2 (en) | 2014-05-07 | 2020-03-03 | Boehringer Ingelheim International Gmbh | Container, indicator device with moveable piercing part, and nebulizer |
WO2015169429A2 (en) | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Container, indicator device, and nebulizer |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
EP4052747A1 (de) | 2014-05-07 | 2022-09-07 | Boehringer Ingelheim International GmbH | Vernebler, indikatorvorrichtung und behälter |
US10643118B2 (en) | 2014-12-10 | 2020-05-05 | Alfred Von Schuckmann | Handheld device with a counter and counter |
DE102014118325A1 (de) | 2014-12-10 | 2016-06-16 | Alfred Von Schuckmann | Zählwerk |
WO2017178294A1 (de) | 2016-04-13 | 2017-10-19 | Alfred Von Schuckmann | Handgerät zur ausgabe einer pharmazeutischen substanz sowie zählwerk für ein solches handgerät |
DE102016106875A1 (de) | 2016-04-13 | 2017-10-19 | Alfred Von Schuckmann | Handgerät zur Ausgabe einer pharmazeutischen Substanz sowie Zählwerk für ein solches Handgerät |
US11351316B2 (en) | 2016-04-13 | 2022-06-07 | Alfred Von Schuckmann | Handheld device for dispensing of a pharmaceutical substance and counter for such handheld device |
Also Published As
Publication number | Publication date |
---|---|
ES2379112T3 (es) | 2012-04-20 |
BRPI0708759A2 (pt) | 2011-06-14 |
IL193562A0 (en) | 2009-05-04 |
BRPI0708741A2 (pt) | 2011-06-14 |
NO20084251L (no) | 2008-12-10 |
AU2007224525A1 (en) | 2007-09-20 |
KR20080099856A (ko) | 2008-11-13 |
DK1993644T3 (da) | 2012-09-03 |
NO20084250L (no) | 2008-12-10 |
US20090056710A1 (en) | 2009-03-05 |
EP1993643A1 (de) | 2008-11-26 |
MX2008011621A (es) | 2008-09-22 |
MX2008011620A (es) | 2008-09-22 |
AU2007224521A1 (en) | 2007-09-20 |
EP1993644A1 (de) | 2008-11-26 |
DK1993643T3 (da) | 2012-05-14 |
US20090050149A1 (en) | 2009-02-26 |
CA2645276A1 (en) | 2007-09-20 |
EP1993644B1 (de) | 2012-05-23 |
US8132565B2 (en) | 2012-03-13 |
JP2009529361A (ja) | 2009-08-20 |
JP2009529360A (ja) | 2009-08-20 |
US8261737B2 (en) | 2012-09-11 |
WO2007104698A1 (de) | 2007-09-20 |
DE102006029753A1 (de) | 2007-09-13 |
ATE541603T1 (de) | 2012-02-15 |
IL193561A0 (en) | 2009-05-04 |
ES2384648T3 (es) | 2012-07-10 |
CA2645262A1 (en) | 2007-09-20 |
KR20080103060A (ko) | 2008-11-26 |
EP1993643B1 (de) | 2012-01-18 |
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