WO2007077640A1 - 貼付剤及びその製造方法 - Google Patents
貼付剤及びその製造方法 Download PDFInfo
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- WO2007077640A1 WO2007077640A1 PCT/JP2006/308630 JP2006308630W WO2007077640A1 WO 2007077640 A1 WO2007077640 A1 WO 2007077640A1 JP 2006308630 W JP2006308630 W JP 2006308630W WO 2007077640 A1 WO2007077640 A1 WO 2007077640A1
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- release film
- plaster
- patch
- film
- producing
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- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
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- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
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- 231100000021 irritant Toxicity 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 240000004308 marijuana Species 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229940116257 pepper extract Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920006306 polyurethane fiber Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 229920006297 regenerated protein fiber Polymers 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00795—Plasters special helping devices
- A61F2013/00817—Plasters special helping devices handles or handling tabs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
Definitions
- the present invention relates to a patch such as a poultice for anti-inflammatory and analgesic or acupuncture treatment and a method for producing the same. More specifically, not only healthy subjects but also elderly people or patients with reduced grip strength, the release force of the release film and the operation up to the application of the patch can be easily performed in a series of operations.
- the present invention relates to an excellent patch that can be applied safely and hygienically without touching the plaster, and a method for producing the same.
- a conventional patch 1 such as a poultice is a white or skin-colored support 2 and an adhesive plaster that is spread on almost the entire surface of the support.
- it is constituted as a laminated structure comprising 3 and a single release film 4 covering the entire surface of the plaster.
- the release film 4 is intentionally displaced by rubbing the corner of the patch with a strong force with a fingertip. To remove the surface force of the plaster 3 and quickly press the plaster directly with your finger before the area has been restored, and slowly stick the adhesive plaster with the other fingertip. And the release film 4 were completely peeled off, and then applied to the affected area with the plaster part and the support.
- This patch 1 comprises a support 2 such as white or skin color, an adhesive paste 3 spread almost all over one surface of the support, and an upper release film attached to the paste. It is composed of two release films, film 4a and lower release film 4b.
- this patch is applied by grasping the grip part of the upper release film 4a with a finger and slowly peeling it, and then holding the grip part of the lower release film 4b.
- the adhesive film is slowly peeled off completely so that the adhesive plaster parts do not adhere to each other, and then attached to the affected part with the plaster part and the support.
- an adhesive paste 3 is spread on almost the entire surface of one surface of the support 2 pulled out from the support roll, and the paste is applied.
- Force to attach release film 4 drawn from release film roll 55 to body surface Cut release film 4 into upper release film 4a and lower release film 4b 80, and stack the end with gripping part fold 81 to paste It can be manufactured by sticking to 3 and forming a laminated body, cutting the laminated body 60 (cutting) 60, and then cutting 70 into the specified dimensions.
- Patent Document 1 Japanese Patent Laid-Open No. 2001-219622
- a patch such as a poultice is a laminate obtained by spreading a paste on almost the entire surface of a support and then sticking a release film on the top of the paste. Since the original fabric is cut into a rectangular shape such as a rectangular shape, the outer peripheral cross section of the laminate of the support, the plaster, and the release film is flushed. Therefore, when peeling film is peeled off at the outer periphery of the patch, there is no hand force to start peeling, so it is necessary to rub the outer periphery with dexterity by hand. Have difficulty.
- the purpose is to prevent repulsion when the grip portion of the lower release film 4b is bent in-line. Since the material was softened by heating the bent part with an ultrasonic seal or the like, and then bent to an arbitrary size and formed with a nip roll, etc., it was unsuitable for high-melting-point materials. Furthermore, when the machine was stopped or restarted, the quality became unstable, and sufficient consideration and management were necessary.
- the present invention solves the problems of the conventional patch described above, and the operation until the release force of the release film is applied not only to healthy subjects but also to elderly people and patients with reduced grip strength.
- the first release film has the shape of a V-type release film folded at the center, and one side of the folded V-type release film is directed to the center of the plaster. So that it is stuck to the plaster surface,
- a second release film is attached to the remaining plaster surface, and an end of the second release film covers a bent portion of the V-shaped first release film.
- the paste is spread on the support. At least half of the surface of the plaster is pasted with a tubular release film, and the tubular release film is cut in half to form a V-shaped first release film folded at the center thereof.
- the invention according to claim 2 is the invention according to claim 1, wherein the second release film adhered to the remaining plaster surface is a sheet-like release film,
- the method for producing a patch is characterized in that the end shape covering the folded portion of the peel-off film is a straight, corrugated or mountain-shaped curve or a combination thereof.
- Still another specific invention according to claim 3 is the invention according to claim 1, wherein the second release film adhered to the remaining plaster surface is a tubular release film.
- the invention according to claim 4 wherein the first release film and the Z or second release film are unstretched polypropylene, stretched polypropylene, polyethylene terephthalate, polybutylene terephthalate, polyethylene, Affixed with polyester, polyurethane, polysilene bule, polystyrene plastic film, paper, synthetic paper, composite film made of synthetic resin alone or laminated, or composite film laminated with aluminum foil or vapor-deposited film It is a manufacturing method of an agent.
- the invention according to claims 5 and 6 is a method for producing a patch in which the first release film and the Z or second release film are silicon-coated or embossed. is there.
- the invention described in claim 7 is a patch manufactured by the manufacturing method described in claim 1 or 6.
- the patch produced by the production method provided by the present invention has the plaster surface adhered by two release films, a first release film and a second release film, and among them, By sticking with a tubular release film and half-cutting the tubular release film, at least the first release film attached to the plaster surface is formed as a V-type first release film, and the other side is gripped. Further, the second release film, that is, the upper release film is characterized in that a grip portion is provided.
- the patch provided by the present invention is provided with a grip portion on the second release film, that is, the upper release film, so that it can be easily gripped with fingers and with a weak force.
- the upper second release film can be peeled off safely and easily.
- the peel strength of the peelable film does not touch the fingers etc. at all during the work up to the application to the affected part, so that the adhesive strength of the plaster itself and the skin followability are not impaired.
- a safe patch can be provided as a patch for application to the skin damage site without sacrificing hygiene.
- the manufacturing method provided by the present invention is excellent in mass productivity and can reduce costs.
- the release film used in the patch of the present invention includes unstretched polypropylene (CPP), stretched polypropylene (OPP), polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyethylene, polyester, polyurethane, Resin films such as polyvinyl chloride and polystyrene, paper, synthetic paper, those obtained by laminating or combining synthetic resins, aluminum foil, laminated films and vapor-deposited films and the above materials, and single materials or In the case of a composite material, it is possible to use a silicon material that has been embossed with silicon, or that has been printed or colored.
- CPP unstretched polypropylene
- OPP stretched polypropylene
- PET polyethylene terephthalate
- PBT polybutylene terephthalate
- Resin films such as polyvinyl chloride and polystyrene
- paper synthetic paper, those obtained by laminating or combining synthetic resins, aluminum foil, laminated films and vapor-deposited
- the method for forming the tubular release film material used in the present invention includes, but is not limited to, an inflation method, a T-die method, a calendar method, a casting method, and the like.
- an inflation method in order to obtain a tube-like film, it is necessary to use a tubing force other than the inflation method. Therefore, a single material that cannot be welded is sealed to enable heat sealing. Layers need to be stacked.
- the thickness of the release film is in the range of 10 to 200 ⁇ m, preferably 25 to 75 ⁇ m. If the thickness of the release film is less than 25 ⁇ m, it is difficult to grip the film itself due to its thinness, and it is not preferable because the film tends to be wrinkled during the manufacture of the patch. In addition, if the thickness of the release film exceeds 75 m, the cutting property in the manufacture of the patch will be reduced, which will increase the cost of the patch itself. Furthermore, the release film itself is more expensive, which is not preferable from the viewpoint of cost.
- the release film is preferably embossed to prevent slipping of fingers during peeling.
- the embossed part is formed on the entire surface of the release film or locally, for example, a grip part.
- the shape of the embossing force is not particularly limited, but preferably a diamond pattern, a lattice pattern, a tortoiseshell pattern, a corrugated pattern, etc., as long as it is easy to grip without finger slipping. It can be formed in the shape of [0034]
- embossing only the inflation method is used for processing with a tube-shaped raw film, and in the case of other film forming methods, there is no particular limitation on whether embossing force is applied before or after the tubing curve. However, if a pattern with severe irregularities is selected, it will be difficult to weld it after the tubing process.
- the grip part of the second release film that is, the overlap part (lamination part) of the upper release film and the lower V-shaped first release film has a width of about 10 to 30 mm. More preferably, a width of 15 to 25 mm is preferable. If the gripping portion is less than 15 mm wide, it is difficult to grip the gripping portion with fingers, and workability due to meandering during production tends to deteriorate, and the yield tends to decrease. Also, if the grip part exceeds 30mm width, it will be easy to grip the grip part with fingers, but it will increase the cost, and it will be easy to squeeze the laminated part when filling the packaging bag. There is no.
- characters, arrows, symbols, illustrations, etc. are displayed or colored on the laminated portion of the upper second release film and the lower V-shaped first release film to clearly define the end portions. It is preferable to do this. In addition, it is also preferable to give embossing power that is different from the others only at the gripping part so that it is more prominent.
- the area ratio of the upper second release film and the lower V-type first release film is 2: 1. If it becomes larger, there is a possibility that the pastes stick to each other when the upper second release film is peeled off, and it is necessary to take care to peel the release film slowly and carefully. Furthermore, when the upper part of the second release film approaches the lower part of the V-type first release film, and when the upper second release film is peeled off, the grip part of the upper and lower release films tend to be grasped simultaneously. It is preferable from becoming.
- the cut surface of the end portion of the grip portion of the second release film located on the upper side is not limited to a straight line, a corrugated shape, a mountain shape, or the like.
- a shape having a straight line to a gentle curve is preferable, and a shape having a sharp convex portion is not preferable because the fingertip may be injured at the tip of the release film.
- the cut surface at the end of the grip portion of the V-type first release film located on the lower side is not limited to a straight line, a wave shape, a mountain shape, or the like.
- a shape having a straight line to a gentle curve is preferred, and a shape having a sharp convex portion is not preferable because the tip of the release film may injure the fingertip.
- the shape of the convex portion having an acute angle is not preferable because the convex portion is obstructed when the paste at the time of manufacture and the lower V-shaped release film are stuck, and the yield is lowered.
- Examples of the support used in the patch of the present invention include woven fabric, non-woven fabric, and laminate, and the presence or absence of stretchability is not limited.
- Specific materials for the support include bast fibers such as paper, cotton, cannabis and jute, cellulose fibers such as vein fibers such as Manila hemp, animal fibers such as wool, silk fibers and feather fibers.
- Natural fiber such as protein fiber, regenerated cellulose fiber such as rayon and cuvula, regenerated fiber such as regenerated protein fiber, semi-synthetic fiber such as cellulose acetate fiber and promix, nylon ceramide fiber, polyethylene terephthalate fiber, polyester fiber, acrylic fiber Polyolefin fibers such as polyethylene fibers and polypropylene fibers, polybutanol alcohol fibers, polyvinyl chloride fibers, polysalt-vinylidene fibers, polysalt-zure-bule fibers, polyurethane fibers, polyoxymethylene fibers, polytetrafluorocarbons Ethylene fiber, polyparaphenylene benzbisthiazole fiber, polyimi Can be mentioned fibers and the like, with a single body or composite fibers of these fibers
- the support is appropriately selected from the above materials in consideration of the tensile strength, thickness, stretchability, etc. depending on the application site, and taking into account the transfer of the drug to the support.
- the plaster used for the patch is effectively used as a patch for an external patch, for example, by containing a drug in the base.
- the plaster contains moisture so that the medicinal effect on the skin can be sufficiently obtained, is sticky, does not soften even at room temperature or higher, and the plaster does not touch the skin. In addition, it is formed so as to have an appropriate cohesiveness.
- a thickener that can stably maintain water in the plaster by about 30% to 80% and has water retention is desirable.
- specific examples of such thickeners include plant systems such as guar gum, locust bean gum, carrageenan, alginic acid, sodium alginate, agar, gum arabic, tragacanth gum, cara gum, pectin, starch, microorganisms such as xanthan gum and acacia gum System, natural polymers such as gelatin and collagen, methinoresenorelose, ethinoresenorelose, hydroxyethinoresenorelose, cellulose cellulose such as ruboxymethylcellulose sodium, soluble starch, carboxymethyl starch, di Semi-synthetic polymers such as starches such as aldehyde starch, burs such as polyvinyl alcohol, polybulur pyrrolidone and polybulur metatalylate, acrylics such as polyataryl acid and sodium polyacrylate
- sodium polyacrylate is particularly preferable. This is because this sodium polyacrylate has high gel strength and excellent water retention. Furthermore, sodium polyacrylate having an average degree of polymerization of 20,000 to 70,000 is preferred. As the average degree of polymerization becomes smaller than 20,000, the thickening effect becomes poor and it becomes impossible to obtain sufficient gel strength, and when the average degree of polymerization is more than 70,000, the thickening effect is too strong, There is a tendency for the workability to decrease, both of which are undesirable.
- sodium polyacrylate can be used in combination with two or more of the above-mentioned water-soluble polymers, for example, by forming a polymer complex with a strong ionic polymer of sodium polyacrylate, thereby further increasing the gel strength and elasticity. Gel can be obtained
- Examples of the wetting agent include polyhydric alcohols such as glycerin, propylene glycol, and sorbitol, and examples of the filler include kaolin, zinc oxide, talc, titanium, bentona. May also be added, such as silica, aluminum silicate, titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, and calcium phosphate.
- a solubilizing agent or an absorption accelerator can be combined, and examples thereof include propylene carbonate, crotamiton, 1-menthol, heart power oil, limonene, diisopropyl adipate and the like.
- methyl salicylate, glycol salicylate, 1 menthol, thymol, mint oil, norlic acid lylamide, pepper extract, etc. can be added and stabilized as necessary. You may add an antioxidant, an emulsifier, etc.
- a cross-linking agent or a polymerizing agent may be added as necessary for the purpose of strengthening the plaster and providing water retention.
- a crosslinking agent is appropriately selected depending on the type of the thickener and the like.
- polyacrylic acid or polyacrylate when selected as the thickener, compounds having at least two epoxy groups in the molecule, hydrochlorides such as Ca, Mg, Al, sulfates, phosphates, Inorganic acid salts such as carbonates, citrates, tartaric acid salts, organic acid salts such as darconate and stearates, oxides such as zinc oxide and anhydrous silicic acid, water such as aluminum hydroxide and magnesium hydroxide
- a crosslinking agent which is a polyvalent metal compound such as an oxide can be preferably used.
- polyvinyl alcohol is selected as the thickener, adipic acid, thioglycolic acid, epoxy compound (epoxychlorohydrin), aldehydes, N-methylol compounds, Complexes such as compounds such as Al, Ti, Zr, Sn, V, Cu, B, and Cr can be suitably used.
- methylvinyl ether Z maleic anhydride copolymer methylvinyl ether Z maleic anhydride copolymer, polyacid compound or alkali metal salt thereof (polyacrylic acid or Tannic acid and its derivatives) can be preferably used.
- polyethylene oxide is selected as the thickening agent
- percoxide, polysulfonazide or the like is preferably used as the crosslinking agent or the polymerization agent.
- methyl vinyl ether Z maleic anhydride copolymer is selected as the thickener
- polyfunctional hydroxy compounds, polyamines, iodine, gelatin, polyvinylbivinylidone, iron, mercury, lead as crosslinking agents or polymerizing agents.
- a salt or the like can be preferably used.
- aldehydes such as formaldehyde, glutaraldehyde, and dialdehyde starch
- diepoxides such as glucosal and butadiene oxide, divinyl as the crosslinking agent or polymerization agent.
- Diketones such as ketones, diisocyanates and the like can be preferably used.
- sodium polyacrylate is selected as the thickener
- a polyvalent metal salt such as lithium hydroxide, zinc hydroxide, aluminum hydroxide or sodium borate is added as a crosslinking agent.
- Zinc salts and aluminum salts are particularly preferred because they promote the crosslinking reaction.
- the concentration of the polyvalent metal salt added as a crosslinking agent is preferably 0.5 to 1.5 equivalents relative to 1 equivalent of the thickener (or water-soluble polymer). If the concentration of the polyvalent metal salt is less than 0.5 equivalent, the crosslinking reaction tends to be too slow and the gel strength tends to be low, and if the concentration of the polyvalent metal salt exceeds 1.5 equivalent, The reaction is too early, the gel is not uniform, and the workability tends to be reduced.
- the poultice is required to have good skin adhesion, to enhance the permeation of the active ingredient through the skin, and to contain as much water as possible.
- the moisture in the plaster body evaporates, the skin force also takes heat, this calorific value gives a refreshing sensation, and the stratum corneum is hydrated by the water molecules that evaporate from the inside, promoting the absorption of the drug .
- the plaster include that it cannot be squeezed at room temperature or in the vicinity thereof, that the paste that hurts when peeled off does not remain on the skin, and that it does not stick.
- the plaster is 5 to 20% by weight thickener, preferably 10 to 15% by weight, 5 to 40% by weight wetting agent, 20% or less by weight filler, 10 to 80% by weight water, dissolved It is preferable to add 0 to 8% by weight of adjuvant and 5% by weight or less, preferably 0.5 to 5% by weight of the drug.
- analgesic examples include indomethacin, ketoprofen, flurbiprofen, ibuprofen, fuerbinac, glycol salicylate, methyl salicylate, glycyrrhizic acid, dipotassium glycyrrhizinate, ⁇ -glycyrrhizic acid and the like.
- Examples of the blood circulation promoting component include tocopherol acetate, capsicum extract, capsaicin, nor-acid lylamide, benzyl nicotinate, benzyl alcohol and the like.
- examples of the antiallergic component include diphenhydramine hydrochloride, chlorfelamine maleate and the like.
- Sarakuko, local irritant ingredients include 1 menthol, camphor, mint oil, eucalyptus oil, etc.
- Sarakuko, local anesthetic ingredients include lidocaine, benzocaine, dibuin, tetracaine, etc.
- the drugs used in the patch are not limited to those described above, and two or more drugs can be used in combination as required.
- the amount of the drug to be blended in the plaster is appropriately determined depending on the type and use of the patch such as a poultice so that an effective amount preset when applied to the patient can be applied to the affected area. Selected.
- FIG. 1 shows a patch such as a knock agent according to Embodiment 1, which is one example of the present invention.
- Figure 1.1 is a perspective view and Figure 1.2 is a side view.
- Knopp agent 1 which is a patch in the embodiment shown in FIG. 1 includes a support 2 made of a nonwoven fabric having elasticity, and a plaster 3 spread on substantially the entire surface of the support 2. And a laminate composed of two release films 41 and 42 adhered to the plaster surface of the plaster 3.
- the first release film 41 located on the lower side is shaped like a V-type release film folded at the center thereof.
- One side of the folded V-shaped first release film 41 is adhered to the end of the plaster surface so that the bent portion 44 is directed toward the center of the plaster,
- the other side of the mold release film is configured as a grip 45.
- the second release film 42 located on the upper side has a V-shaped release film shape bent at the center thereof.
- One side of the folded V-shaped second release film 42 is adhered to the remaining plaster surface, and the bent portion 47 of the second release film is positioned on the lower side. It is laminated so as to cover the bent portions 44 of 41, and the other surface is configured as a grip portion 46.
- the plaster 3 spread on substantially the entire surface of the support 2 is a plaster 3 that is equivalent to sodium polyacrylate, etc.
- a medicinal component for example, a drug such as felbinac, which is an anti-inflammatory analgesic, and water are contained.
- a tube-like release film having a thickness of 30 to 50 ⁇ m and having an unstretched polypropylene force is substantially half-faced.
- Both the first release film 41 and the second release film 42 have a V-type release film shape obtained by semi-cutting a tubular release film.
- the pasted area ratio of the second release film 42 located on the upper side and the V-type first release film 41 located on the lower side to the plaster 3 was 1: 1. It is said that.
- the overlapping portion 48 that is a laminated portion of the second release film 42 located on the upper side with respect to the first release film is preferably within a range of 15 to 25 mm in width.
- Fig. 2 shows a schematic diagram of the steps in the method for producing the cataplasm 1 as a patch based on this example.
- the adhesive paste 3 is spread on the support 2 drawn from the support roll 25, and the plaster surface of the tubular release film that becomes the upper second release film 42 from the release film roll 55 and A tubular release film to be the lower first release film 41 is pasted to form a laminate, and the laminate is cut in half so that the tubular release film is cut 60, and then cut to a predetermined size 70 Can be manufactured.
- FIG. 3 is a schematic perspective view showing an operation of peeling the second peeling film 42 located on the upper side in the cataplasm 1 of the above embodiment of the present invention.
- FIG. 4 is a schematic side view showing an operation of peeling the second release film 42 located on the upper side of the cataplasm 1 of the above embodiment of the present invention and sticking the surface with the almost half of the plaster 3 exposed to the affected part.
- FIG. 3 is a schematic perspective view showing an operation of peeling the second peeling film 42 located on the upper side in the cataplasm 1 of the above embodiment of the present invention.
- FIG. 4 is a schematic side view showing an operation of peeling the second release film 42 located on the upper side of the cataplasm 1 of the above embodiment of the present invention and sticking the surface with the almost half of the plaster 3 exposed to the affected part.
- FIG. 5 is a schematic side view showing the operation of applying the plaster 3 to the affected area while peeling off the remaining V-type first release film 41 located after the operation of FIG.
- the grip part 46 of the second release film 42 located on the upper side of the knitting agent 1 is held with fingers (not shown), and the upper second release film 42 is peeled off. To go. When all of the second release film 42 is peeled off, the plaster surface of the plaster 3 to which the second release film 42 is adhered (the half surface of the plaster 3) is exposed.
- the first release film 41 is pulled while sliding the finger touching the grip portion 45 of the V-type first release film 41 located on the lower side in the outward direction of the nop agent. By peeling off, the exposed plaster 3 is naturally applied to the affected area.
- FIG. 6 shows a patch such as a cataplasm in Embodiment 2, which is another example of the present invention.
- Fig. 6.1 is a perspective view and Fig. 6.2 is a side view.
- the nodal agent 1 includes a support 2 constituting the paste, a paste 3 spread on the entire surface of the support 2, and two pastes applied to the paste surface of the paste 3.
- the structure of the laminate composed of a single sheet of release films 41 and 42 is the same as that of the previous example.
- the plaster spread on the substantially entire surface of the support 2. 3 is a paste 3 made of sodium polyacrylate and the like, and the paste 3 contains a drug such as indomethacin, an anti-inflammatory analgesic, and water as a medicinal component.
- the upper side second release film is used as the two release films 41 and 42.
- the film 42 is an unstretched polypropylene film with a thickness of 30 to 50 m, and a release film that has been further embossed with a turtle shell pattern.
- an unstretched polypropylene film which is a half-cut tube-like release film subjected to diamond pattern embossing force, is selected.
- the ratio of the area of the second release film 42 located on the upper side to the paste 3 of the V-type first release film 41 located on the lower side is 1: 1. Yes.
- the overlapping portion 48 serving as a laminated portion of the second release film 42 located on the upper side with respect to the first release film is preferably in the range of 15 to 25 mm in width.
- Fig. 7 shows a schematic diagram of the steps in the method for producing the patch 1 which is a patch based on this example.
- the adhesive paste 3 is spread on the support 2 drawn out from the support roll 25, and the surface of the paste is peeled off from the second release film roll 55 into the upper second release film 42.
- the tube-like release film to be the lower first release film 41 is pulled out and stuck to form a laminate, and the laminate is cut by the tube-like release film. Can be cut in half, and then cut to a predetermined size.
- FIG. 8 is a schematic perspective view showing the working state of peeling the second release film 42 located on the upper side in the cataplasm 1 of the above-described embodiment of the present invention. It is the same as the case of.
- FIG. 9 shows a sticking agent such as a knocking agent in Embodiment 3, which is still another example of the present invention.
- Fig. 9.1 is a perspective view and Fig. 9.2 is a side view.
- the nodal agent 1 is bonded to the base 2 of the base 2, the plaster 3 spread on the entire surface of the base 2, and the base 3 of the base 3 Sheet of release film 41, 42
- the structure as a laminate is the same as in the previous example, and the ratio of the area of the support, the paste, and the upper second release film 42 and the lower first release film 42 to the paste, Furthermore, since the size of each gripping part is the same as that of the second embodiment, description thereof is omitted.
- the second embodiment is different from the second embodiment in that the upper second release film 42 and the lower first release film 41 force are low-density polyethylene of 10 to 30 ⁇ m on a polyethylene terephthalate film of 25 to 38 ⁇ m.
- the film was laminated and siliconized, and the release film with diamond embossing was selected, and the cut surface of the grip portion 46 of the upper second release film 41 was corrugated. .
- Fig. 10 shows a schematic diagram of the steps in the method for producing the patch 1 which is a patch based on this example.
- adhesive paste 3 is spread on support 2 drawn out from support roll 25, and the surface of the paste becomes second release film 42 from the second release film roll 55. And, from the first release film row 55, the tubular release film that becomes the lower first release film 41 is pulled out and stuck to form a laminate, and the laminate is cut into 60 pieces. And then cut into a predetermined dimension.
- the material of the upper second release film 42 and the lower first release film 41 is a polyethylene terephthalate film with a thickness of 25 to 38 ⁇ m, it has higher bending resistance than an unstretched polypropylene film. Therefore, when gripping the grips of the upper and lower second and first release films, there is a possibility that the fingers may be accidentally damaged, particularly by the upper second release film 42. In order to prevent this, the possibility of damaging the fingers can be greatly reduced by corrugating the cut surface at the end.
- the shape of the end of the gripping portion is not limited to the waveform as in the present embodiment, and may be a mountain-shaped curve or a combination thereof! / Well, ... Such modifications are shown in FIGS. 11 and 12.
- FIG. 11 Such modifications are shown in FIGS. 11 and 12.
- the patch provided by the present invention has the plaster surface attached with two release films, a first release film and a second release film, and provided with grip portions on both release papers.
- the peeling film can be peeled off safely and easily with a weak force, and a series of operations up to the sticking with a single hand can be easily performed.
- the adhesive film does not impair the adhesive strength and skin followability of the adhesive film itself without touching the fingers etc. at all during the work up to the application to the affected area.
- the adhesive film since there is no contamination of the plaster, it can be applied hygienically, and its industrial contribution is significant.
- FIG. 1.1 is a perspective view showing a cataplasm in Embodiment 1 which is an example of the present invention.
- FIG. 1.2 is a side view of the cataplasm in Embodiment 1.
- FIG. 2 is a schematic diagram of steps in a method for producing a cataplasm as a patch based on the above example.
- FIG. 3 is a schematic perspective view showing an operation of peeling the second release film located on the upper side in the nope agent of the above embodiment of the present invention.
- FIG. 4 is a schematic side view showing an operation of peeling the second release film located on the upper side of the knitted preparation of the above-mentioned embodiment of the present invention and sticking the surface on which almost half of the plaster is exposed to the affected area.
- FIG. 5 is a schematic side view showing the operation of applying the plaster to the affected area while pulling off the remaining V-shaped first release film located after the operation of FIG. 3.
- FIG. 6.1 is a perspective view showing a cataplasm in Embodiment 2 which is another example of the present invention.
- FIG. 6.2 is a side view of the cataplasm in Embodiment 2.
- FIG. 7 is a schematic view of steps in a method for producing a cataplasm as a patch according to another embodiment of the present invention.
- FIG. 8 is a schematic perspective view showing a working state of peeling the second release film located on the upper side in a cataplasm as a patch based on another example of the present invention.
- FIG. 9.1 is a perspective view showing a cataplasm in Embodiment 3 which is still another example of the present invention.
- FIG. 9.2 is a side view of the cataplasm in Embodiment 3.
- FIG. 10 is a schematic view of steps in a method for producing a cataplasm as a patch according to still another example of the present invention.
- FIG. 11 is a view showing a modification of the end portion of the grip portion.
- FIG. 12 is a view showing a modification of the end portion of the grip portion.
- FIG. 13.1 is a perspective view showing a conventional poultice.
- FIG. 13.2 A side view of a conventional cataplasm.
- FIG. 14 is a schematic view of steps in a conventional method for producing a cataplasm.
- FIG. 15.1 is a perspective view showing another conventional cataplasm.
- FIG. 15.2 is a perspective view showing a state in which another conventional cataplasm release paper is peeled off.
- FIG. 15.3 is a side view of another conventional cataplasm.
- FIG. 16 is a schematic diagram of steps in another conventional method for producing a cataplasm.
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Description
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Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
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KR1020087018067A KR101332999B1 (ko) | 2005-12-28 | 2006-04-25 | 부착제 및 그 제조 방법 |
CA2634272A CA2634272C (en) | 2005-12-28 | 2006-04-25 | Adhesive patch and production method thereof |
US12/159,446 US20100298788A1 (en) | 2005-12-28 | 2006-04-25 | Adhesive Patch and Production Method Thereof |
DK06745658.2T DK1967171T3 (da) | 2005-12-28 | 2006-04-25 | Fremgangsmåde til fremstilling af et hæfteplaster |
CN2006800496439A CN101351181B (zh) | 2005-12-28 | 2006-04-25 | 贴剂及其制备方法 |
AU2006333989A AU2006333989B2 (en) | 2005-12-28 | 2006-04-25 | Adhesive patch and production method thereof |
ES06745658T ES2386730T3 (es) | 2005-12-28 | 2006-04-25 | Procedimiento de producción de un parche adhesivo |
EP06745658A EP1967171B1 (en) | 2005-12-28 | 2006-04-25 | Production method of an adhesive patch |
HK09101230.9A HK1121367A1 (en) | 2005-12-28 | 2009-02-10 | Production method of an adhesive patch |
Applications Claiming Priority (2)
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JP2005377554A JP4769575B2 (ja) | 2005-12-28 | 2005-12-28 | 貼付剤及びその製造方法 |
JP2005-377554 | 2005-12-28 |
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PCT/JP2006/308630 WO2007077640A1 (ja) | 2005-12-28 | 2006-04-25 | 貼付剤及びその製造方法 |
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US (1) | US20100298788A1 (ja) |
EP (1) | EP1967171B1 (ja) |
JP (1) | JP4769575B2 (ja) |
KR (1) | KR101332999B1 (ja) |
CN (1) | CN101351181B (ja) |
AU (1) | AU2006333989B2 (ja) |
CA (1) | CA2634272C (ja) |
DK (1) | DK1967171T3 (ja) |
ES (1) | ES2386730T3 (ja) |
HK (1) | HK1121367A1 (ja) |
WO (1) | WO2007077640A1 (ja) |
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WO2009107477A1 (ja) | 2008-02-27 | 2009-09-03 | 久光製薬株式会社 | 貼付製剤 |
US8329210B2 (en) * | 2008-09-23 | 2012-12-11 | Pharmapatch, Llc | Twin transdermal drug delivery patch |
JP5210379B2 (ja) * | 2008-12-26 | 2013-06-12 | 正剛 相賀 | 外用貼付剤 |
JP5663477B2 (ja) * | 2009-07-01 | 2015-02-04 | 凸版印刷株式会社 | 針状体 |
DE102010000661A1 (de) * | 2010-01-04 | 2011-07-07 | Acino Ag, 83714 | Verfahren und Vorrichtung zur Herstellung einer überlappenden Schutzfolie für ein transdermales therapeutisches System |
CN103189097B (zh) * | 2010-07-29 | 2016-01-06 | 参天制药株式会社 | 带药剂的支承体及其制造方法 |
US8939953B2 (en) | 2010-10-18 | 2015-01-27 | Weiru Shao | Methods of using multilayer medical sponges |
US20110066124A1 (en) * | 2010-10-18 | 2011-03-17 | Weiru Shao | Multilayer Medical Sponge |
DE102011080389B4 (de) * | 2011-08-03 | 2019-02-14 | Luye Pharma Ag | Schutzfolienwechsler |
DE102011080390B3 (de) * | 2011-08-03 | 2012-07-12 | Acino Ag | Applikationshilfe |
US9170178B2 (en) | 2012-04-16 | 2015-10-27 | Edward Sobek | Composition, device, and method for biological air sampling |
EP2952337B1 (en) | 2014-06-02 | 2018-08-01 | Siemens Aktiengesellschaft | Method for manufacturing a composite product |
JP2017164191A (ja) * | 2016-03-15 | 2017-09-21 | 凸版印刷株式会社 | 経皮投与デバイス |
DE102017107468B4 (de) * | 2017-04-06 | 2019-02-21 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur herstellung eines, insbesondere oralen, wirkstofflaminats und wirkstofflaminat, insbesondere orales wirkstofflaminat |
CN112675036B (zh) * | 2021-01-07 | 2021-12-03 | 黑龙江省医院 | 一种中医护理药膏加工设备 |
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- 2005-12-28 JP JP2005377554A patent/JP4769575B2/ja not_active Expired - Fee Related
-
2006
- 2006-04-25 US US12/159,446 patent/US20100298788A1/en not_active Abandoned
- 2006-04-25 DK DK06745658.2T patent/DK1967171T3/da active
- 2006-04-25 WO PCT/JP2006/308630 patent/WO2007077640A1/ja active Application Filing
- 2006-04-25 CN CN2006800496439A patent/CN101351181B/zh active Active
- 2006-04-25 CA CA2634272A patent/CA2634272C/en not_active Expired - Fee Related
- 2006-04-25 AU AU2006333989A patent/AU2006333989B2/en not_active Ceased
- 2006-04-25 ES ES06745658T patent/ES2386730T3/es active Active
- 2006-04-25 KR KR1020087018067A patent/KR101332999B1/ko active IP Right Grant
- 2006-04-25 EP EP06745658A patent/EP1967171B1/en not_active Not-in-force
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2009
- 2009-02-10 HK HK09101230.9A patent/HK1121367A1/xx not_active IP Right Cessation
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Title |
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See also references of EP1967171A4 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109330887A (zh) * | 2018-09-21 | 2019-02-15 | 甘肃祖师麻制药有限公司 | 下丹装置、自动下丹系统及膏药炼制设备 |
CN109330887B (zh) * | 2018-09-21 | 2021-10-22 | 甘肃祖师麻制药有限公司 | 下丹装置、自动下丹系统及膏药炼制设备 |
Also Published As
Publication number | Publication date |
---|---|
DK1967171T3 (da) | 2012-07-16 |
AU2006333989A1 (en) | 2007-07-12 |
CN101351181A (zh) | 2009-01-21 |
JP4769575B2 (ja) | 2011-09-07 |
KR20080081064A (ko) | 2008-09-05 |
CA2634272A1 (en) | 2007-07-12 |
AU2006333989B2 (en) | 2011-09-08 |
HK1121367A1 (en) | 2009-04-24 |
EP1967171A1 (en) | 2008-09-10 |
CA2634272C (en) | 2014-08-26 |
JP2007175300A (ja) | 2007-07-12 |
ES2386730T3 (es) | 2012-08-28 |
US20100298788A1 (en) | 2010-11-25 |
EP1967171A4 (en) | 2011-06-08 |
CN101351181B (zh) | 2012-02-01 |
EP1967171B1 (en) | 2012-06-13 |
KR101332999B1 (ko) | 2013-11-25 |
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