WO2007074832A1 - Méthode, système et composition pour diagnostiquer un cancer du poumon à petites cellules et méthode de dépistage apparentée - Google Patents

Méthode, système et composition pour diagnostiquer un cancer du poumon à petites cellules et méthode de dépistage apparentée Download PDF

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Publication number
WO2007074832A1
WO2007074832A1 PCT/JP2006/325937 JP2006325937W WO2007074832A1 WO 2007074832 A1 WO2007074832 A1 WO 2007074832A1 JP 2006325937 W JP2006325937 W JP 2006325937W WO 2007074832 A1 WO2007074832 A1 WO 2007074832A1
Authority
WO
WIPO (PCT)
Prior art keywords
tslc1
cancer
seq
protein
expression
Prior art date
Application number
PCT/JP2006/325937
Other languages
English (en)
Japanese (ja)
Inventor
Yoshinori Murakami
Original Assignee
Japan Health Sciences Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Health Sciences Foundation filed Critical Japan Health Sciences Foundation
Priority to JP2007551990A priority Critical patent/JP5131751B2/ja
Publication of WO2007074832A1 publication Critical patent/WO2007074832A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

L’invention concerne une toute nouvelle technique de diagnostic du cancer (particulièrement le cancer du poumon à petites cellules). Suite à des études intensives faites par l'inventeur, l'objet selon l’invention a été réalisé en découvrant qu’en particulier le niveau d'expression de TSLC1 et Rac1 (surexpression, modification de chaîne de sucre et activation) dans la voie moléculaire du TSLC1 est en rapport étroit avec l’apparition du cancer (particulièrement le cancer du poumon à petites cellules). Il s’agit d’une méthode comprenant les étapes consistant à A) observer une augmentation de l'expression ou une modification d'une chaîne de sucre TSLC1, ou une activation de Rac1 ; et B) indiquer une manifestation d’un cancer par l’augmentation de l'expression, la modification d’une chaîne de sucre ou un changement dans l'activation par rapport à un individu normal.
PCT/JP2006/325937 2005-12-28 2006-12-26 Méthode, système et composition pour diagnostiquer un cancer du poumon à petites cellules et méthode de dépistage apparentée WO2007074832A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007551990A JP5131751B2 (ja) 2005-12-28 2006-12-26 小細胞肺がんの診断のための方法、システムおよび組成物ならびに関連するスクリーニング方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005-380332 2005-12-28
JP2005380332 2005-12-28

Publications (1)

Publication Number Publication Date
WO2007074832A1 true WO2007074832A1 (fr) 2007-07-05

Family

ID=38218052

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/325937 WO2007074832A1 (fr) 2005-12-28 2006-12-26 Méthode, système et composition pour diagnostiquer un cancer du poumon à petites cellules et méthode de dépistage apparentée

Country Status (2)

Country Link
JP (1) JP5131751B2 (fr)
WO (1) WO2007074832A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8420084B2 (en) 2009-03-05 2013-04-16 Medarex, Inc. Fully human antibodies specific to CADM1
JP2014098712A (ja) * 2007-09-11 2014-05-29 Cancer Prevention And Cure Ltd ヒト肺組織の病態を示すヒト血清中のタンパク質の同定
US9903872B2 (en) 2006-08-29 2018-02-27 Oxford Biotherapeutics, Ltd. Identification of protein associated with hepatocellular carcinoma, gliobastoma and lung cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MASUDA M. ET AL.: "Gan Yokusei Tanpakushitsu TSLC1 no Johi Saibokan Secchaku ni Okeru Rho Family Teibunshi G Tanpakushitsu no Kassei Yokusei", DAI 28 KAI ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN KOEN YOSHISHU, 25 November 2005 (2005-11-25), pages 498 (2P-0898), XP003015024 *
MASUDA M. ET AL.: "Tumor Suppressor in Lung Cancer (TSLC)1 Suppresses Epithelial Cell Scattering and Tubulogenesis", J. BIOL. CHEM., vol. 280, no. 51, 23 December 2005 (2005-12-23), pages 42164 - 42171, XP003015023 *
MURAKAMI Y. ET AL.: "Saibo Secchaku Bunshi TSLC1/IGSF4 ni yoru Gan Shinten no Yokusei, Narabi ni Sokushin Kiko", DAI 28 KAI ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN KOEN YOSHISHU, 25 November 2005 (2005-11-25), pages 73 (W2N-1), XP003015025 *
SUSSAN T.E. ET AL.: "Tumor suppressor in lung cancer 1(TSLC) alters tumorigenic growth properties and gene expression", MOL. CANCER, vol. 4, August 2005 (2005-08-01), pages 28, XP021008250 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9903872B2 (en) 2006-08-29 2018-02-27 Oxford Biotherapeutics, Ltd. Identification of protein associated with hepatocellular carcinoma, gliobastoma and lung cancer
JP2014098712A (ja) * 2007-09-11 2014-05-29 Cancer Prevention And Cure Ltd ヒト肺組織の病態を示すヒト血清中のタンパク質の同定
JP2017049265A (ja) * 2007-09-11 2017-03-09 キャンサー・プリヴェンション・アンド・キュア，リミテッド ヒト肺組織の病態を示すヒト血清中のタンパク質の同定
US8420084B2 (en) 2009-03-05 2013-04-16 Medarex, Inc. Fully human antibodies specific to CADM1

Also Published As

Publication number Publication date
JP5131751B2 (ja) 2013-01-30
JPWO2007074832A1 (ja) 2009-06-04

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