WO2007049986A1

WO2007049986A1 - Ultrafine velvet antlers powder, method for the production thereof and elixir exirius for balneotherapy based on said ultrafine velvet antlers powder

Info

Publication number: WO2007049986A1
Application number: PCT/RU2005/000524
Authority: WO
Inventors: Sergei Alekseevich Nerushai; Georgy Mikhailovich Grechko
Original assignee: Sergei Alekseevich Nerushai; Georgy Mikhailovich Grechko
Priority date: 2005-10-27
Filing date: 2005-10-27
Publication date: 2007-05-03

Abstract

The invention relates to preparative forms and to a velvet antlers processing method. The inventive ultrafine velvet antlers powder, whose particle size ranges from 0-1 to 30 mkm, contains in the structure thereof a nonradioactive carbon C13 isotope in a quantity equal to or greater than 1.3 % of a final product carbon content, also comprises a sorbent and salt additives at the following component ratio: 5.0-15.0 mass % sorbent, 15.0-35.0 mass % salt additives, the rest being the velvet antlers powder. The inventive method consists in mechanically removing hair from the caribou, maral, Siberian stag or axis deer velvet antlers, in grinding said material in such a way that the size of the particles thereof rages from 5 to 10 mm and in drying the material by an airflow whose temperature is equal to or less than 70 °C, in regrinding the material until the mean particle size of 0.1mm is attained and in redrying it by an airflow having the same temperature, in adding an abrasive material having a residual moisture equal to or less than 3 mass % into the thus obtained product and simultaneously stirring it, in milling the obtained mixture in a jet mill in such a way that an ultrafine velvet antlers powder is produced . The abrasive material is embodied in the form of a salt additives and sorbent mixture and is used in the quantity equal to or greater than 20 % of the ground material at the component ratio of 1:1-5:1 and the particle size equal to or less than 150 mkm. The elixir comprises a water-alcohol extract of said velvet antlers powder at the following component ratio: 1.0-10.0 mass % velvet antlers powder and 35.0-45.0 mass % alcohol, the rest being water.

Description

Ultrafine antler powder, method for its preparation and elixir

"EXCIRUS" for baths based on ultrafine antler powder

Technical field

The invention relates to preparative forms and processing technology of raw materials of natural origin, in particular antlers of deer, red deer, sika and reindeer, to obtain a biologically active powder, which can be used in biotechnology to obtain stimulators of the growth of microorganisms, in the biochemical industry as a raw material for for producing hormones and biologically active peptides in the food industry as flavoring, mineral and vitamin supplements and the medical industry for receiving immunostimulating drugs and therapeutic baths in balneotherapy.

State of the art

Known preparations of antlers in dry and liquid form and modern methods for producing biologically active substances from antlers of red deer, red deer, sika and reindeer, which are based on grinding the product to a powder state with a particle size of about 0.1 mm and extraction of biologically active substances with various extractants (water, alcohol, etc.) followed by removal of the solvent or using the product in liquid form (SU, Al, 1814900, 05/15/1993; RU, Cl, 2019179, 09/15/1994; RU, Cl, 2045269, 10/10/1995 ; RU, Cl, 2054292, 02.20.1996).

However, studies show that 90% of the total content of individual amino acids and 30% of lipids remain in the waste after the extraction of biologically active substances. In addition, the following remains in the waste (oil cake): proteins (protein compounds) 51%; amino acids 75-78%; in addition, 10 essential amino acids (up to 12%) were found, which is 55% of all amino acids, of which up to 11% glycine, 10% arginine, 6% threonine, 3-4% phenylanine, etc. Waste contains 12 macro- and micronutrients, the largest amount of which is 26,000 mcg / kg phosphorus in dry samples. A study of waste finally confirmed the imperfection of canning in the technology for the production of pharmaceutical preparations from antlers.

The most promising technology seems to be the production of a powdery product from raw materials (antlers) bypassing the extraction stage.

A powdered biogenic preparation and a method for producing it from ossified deer antlers by grinding them to a particle size of about 250 μm (over 80%), a specific surface of 100 m ² / g and a pore volume of about 3 m ² / g are known (RU, Cl, 2077887, 04/27/1997).

However, the powdery preparation obtained in this way has insufficient digestibility by the body and low bioavailability of the biologically active substances contained in the preparation due to the fact that it is used in the form of conventional flour with a particle size of about 250 microns.

Known dosage form of deer antlers and a method for its preparation, including cleaning, drying and crushing of canned antlers. Moreover, the antlers are crushed into particles of such sizes that retain the authenticity of the raw materials (Patent Application RU, 95104242/14, 02/27/1997).

However, when describing this technology, the specific particle size of the final powdery product is not indicated, as a result of which the invention is formulated at the level of the problem statement. Moreover, this technology cannot be implemented on an industrial scale, because problems associated with obtaining particles less than 1 μm are not resolved: elimination of electrostatic effects, prevention of coagulation (sticking) of particles, etc.

Known pharmaceutical composition containing flour from antlers of deer, or deer, or sika deer (45.0-55.0 wt.%), Icing sugar (49.9-49.96 wt.%) And vanillin (0.04- 0.06 wt.%) And a method for producing antler flour, comprising mechanically removing wool from deer antlers, red deer or sika deer, crushing the material to a particle size of 5-10 mm and its drying by air flow with a temperature of not more than 7O ⁰ C, repeated grinding of the material to an average particle size of 100 μm and its repeated drying by air flow at the same temperature (RU ₅ Cl, 2070048, 12/10/1996).

However, the powdery preparation obtained by the above method also has insufficient digestibility by the body and low bioavailability of the biologically active substances contained in the preparation due to the fact that it is used in the form of conventional flour with a particle size of about 100 μm. The closest technical solution (prototype) is an ultrafine powder from deer antlers, or reindeer, or red deer with a particle size of 0.1-30.0 μm and a moisture content of not more than 2 wt.%, As well as a method for producing ultrafine powder from deer antlers for preparation of pharmaceutical, cosmetic preparations or food additives (RU, Cl, 2146525, 03.20.2000). The method includes mechanical removal of wool from deer antlers, red deer or sika deer, crushing the material to a particle size of 5-10 mm and drying it with an air stream with a temperature of not more than 7O ⁰ C, repeated grinding of the material to an average particle size of 0.1 mm and repeated its drying by air flow at the same temperature. Next, a ferromagnetic powder with a particle size of 1.0-50.0 μm in a ratio of 1: 1 to 2: 1 is introduced into the obtained product, the product is subjected to additional grinding in a vortex mill in the presence of the specified ferromagnetic powder to obtain ultrafine material from antlers with a particle size 0.1-30.0 μm and a moisture content of not more than 2 wt.%, The removal of ferromagnetic powder from the mixture by the action of a constant magnetic field on the specified mixture and the packaging of the finished powder product in a vacuum package. As a ferromagnetic powder, a mixture of iron with iron oxide is used in a ratio of 1: 1, and the ferromagnetic powder is pre-dried to a residual moisture content of not more than 1-2 mass%. A ferromagnetic powder with such a component composition and particle size provides an increase in the degree of crushing of material from antlers in a vortex mill into smaller particles due to its abrasive properties, as well as at the same time contributes to a more complete removal of residual moisture from the material being ground due to the absorption of moisture by iron oxide. Ferromagnetic powder also contributes to the disaggregation of the crushed material, a more uniform temperature distribution in its volume and eliminates the accumulation of static electricity, as a result of which “milder” crushing conditions of the material are ensured, while maintaining its biological properties.

However, this prototype technology for producing ultrafine powder is quite complex with a large number of operations; during its implementation, the quality of the finished product is reduced due to the fact that it is almost impossible to completely remove the ferromagnetic particles and the remaining particles contaminate the finished product. In addition, some losses of the ultrafine powder are formed when ferromagnetic particles are removed from it, onto which antler particles are adhered. The quality of the ultrafine powder is reduced due to its partial oxidation upon contact with a metal powder - ferromagnetic abrasive particles.

The closest analogue (prototype) of the liquid extract from antlers is an alcohol-based extract of antler powder (RU, Cl, 2054292,. 20.02. 1996) with the following quantitative content of components (May.%): Antler powder 5.0

Alcohol 30.0

Water the rest is up to 100%.

However, when obtaining such a liquid extract, antler powder is used, obtained by grinding dry particles from antlers up to 1 cm in a ball mill with a main particle size of 100-200 μm, as a result of which the extractability of biologically active substances upon receipt of such a liquid extract is low. In this regard, the biological activity of the final product (liquid extract from antlers) will also be insufficient. Disclosure of invention

The technical result of the invention is a significant simplification of the manufacturing technology of ultrafine powder from antlers, improving the quality of the finished ultrafine powder from antlers and reducing its losses, as well as obtaining a more biologically active water-alcohol extract from antlers for therapeutic baths based on it.

The specified technical result is achieved in that the ultrafine powder from antlers of deer, deer or reindeer with a particle size of 0.1-30.0 μm, according to the invention, it (ultrafine powder from antlers) in its structure has a non-radioactive isotope of carbon C ¹³ in quantities not less than 1.3% of the carbon content in the finished product, obtained in accordance with paragraphs 3-6 of the present claims and additionally contains a sorbent and salt additives in the following components (wt.%): sorbent 5.0-15 0, salt additives 15.0-35.0 ultrad spersny powdered antler balance to 100%

The ultrafine powder from antlers contains zeolite as a sorbent, and sodium chloride or sea salt as salt additives.

The specified technical result is also achieved by the fact that in the method of producing ultrafine powder from antlers of deer, deer or reindeer and sika deer, including mechanical removal of wool from antlers, crushing the material to a particle size of 5-10 mm and drying it with an air stream with a temperature of no more 7O ⁰ C, re-grinding the material to an average particle size of 0.1 mm and re-drying it with an air stream at the same temperature, introducing abrasive powder into the resulting product while stirring with a residual moisture content of not more than 3 wt.% in an amount sufficient for efficient crushing of the product, grinding the resulting mixture in a vortex mill in the presence of the specified abrasive powder to obtain ultrafine material from antlers with a particle size of 0.1-30 μm and a moisture content of not more than 3 wt.% followed by packing the finished powder product in a vacuum package, according to the invention, as an abrasive powder, in the amount of not less than 20% by weight of the milled material, a mixture of salt additives with a sorbent taken in a ratio of from 1: 1 to 5: 1 with a size of particles of not more than 150 microns, and the finished ultrafine antler powder in its structure has a non-radioactive carbon isotope C ¹³ B in an amount of at least 1.3% of the carbon content in the finished product, which is a marker of product authenticity.

Sodium chloride or sea salt is used as salt additives in the method, and zeolite is used as a sorbent.

When the abrasive powder content is less than 20 wt.%, The quality of grinding material from antlers decreases, the uniformity of temperature distribution in the volume of the material and the efficiency of removing residual moisture and static electricity from it are violated. When the ratio of salt additives and sorbent in an abrasive powder is less than 1: 1, the grinding efficiency of the material decreases, and when the ratio in a mixture of salt additives and sorbent is more than 5: 1, the efficiency of removing residual moisture from the crushed material decreases, the quasi-hydrothermal soft grinding mode is violated

When grinding the product in a vortex mill, the vibratory-acoustic field with a frequency of 30-300 Hz and an oscillation amplitude of 1.0-20.0 μm is additionally exposed to the mixture flow of the product with abrasive powder. This increases the efficiency of crushing the material, removing moisture and static electricity from it.

The specified technical result is also achieved by the fact that the elixir "EXCIRUS" for therapeutic baths, including a water-alcohol extract from crushed antlers, according to the invention, as crushed antlers, it contains ultrafine powder from antlers with a particle size of -30.0 μm. received in accordance with p. 3-6 of the present claims, with the following content of components (wt.%): Ultrafine powder from antlers 1,0-10,0 alcohol 35.0-45.0 water the rest is up to 100%.

The therapeutic and prophylactic properties of the EXIRUS elixir are determined by the content of ultrafine antler powder in it, which has high bioavailability and an increased content of the non-radioactive C ¹³ carbon isotope in it in an amount of at least 1.3% of the carbon content of the powder.

Elixir "EXCIRUS" for therapeutic baths may additionally contain phytoextracts in the amount of 0.1-5.0% by weight of the elixir. As phytoextracts, the elixir contains fir oil or extracts of motherwort grass, cinnamon grass, ledum grass and hawthorn flowers in a ratio of 9: 3: 2: 1, respectively.

Phytoextracts are selected in such a way (with the property of lowering blood pressure) that their use as part of an antioxidant elixir expands the scope of use of the elixir, in particular in the treatment of patients with grade 1 and 2 hypertension in combination with other diseases. The combined use of antler powder and fir oil enhances their overall effect on the body and also allows you to expand the indications for use in balneotherapy with a high sanogenetic effect.

When mass spectrometric study of the inventive ultrafine powder from antlers found in it an excessive amount of carbon isotope 13, which in such an amount is not found in other biomaterials, in particular products from antlers. This is due to the claimed technology of "soft" grinding, due to the special mechanochemistry of the interaction of the crushed and abrasive materials. The beneficial effect of the non-radioactive isotope of carbon ¹³ on the cells of the body is justified in example 7.

In addition, in order to avoid fakes and falsifications, the authenticity of the inventive antler powder is verified by C ³ isotope analysis (1.3 - 1.47% of the carbon content) by mass spectrometry. The diameter of the particles obtained by grinding is less than 30 microns. As a result of such processing, the mechanochemical activation of the material occurs and its physicochemical properties change. The abrasive crystalline component of this mixture (salt additives) allows you to achieve a uniform distribution of destructive forces ("ydapa") applied to destructible antler material in a vortex mill. An admixture of a natural sorbent (zeolite) is a dry source of water molecules, which makes it possible to simultaneously provide quasi-hydrothermal mild grinding conditions and to prevent local overheating and the formation of peroxide and radical products in the reaction mixture (1. VV Volddurev. 11, p. 11, 2001. 2. VV Boldurev. Meshaphemistroff of Solids: Rast, Prosept, apt Rocrests. J. Mat. Supth. Roses. VoI. 87, No. 34, pp. 121-131, 2000).

The sorbent zeolite is a natural mineral, belongs to the aluminosilicates of the crystalline structure. Zeolite-based sorbent is used in medicine in many pathological processes. In particular, the drug normalizes the functional state of the liver, taking on a significant part of its antitoxic function. As the zeolite, the mineral glauconite obtained from the Kari deposit in the Chelyabinsk region by grinding it to a fraction of 0.01-0.1 mm can be used. The name glauconite comes from the Greek "glaucos" - bluish-green. According to the decision of the International Nomenclature Committee, glandular dioctahedral mica should be called glauconite. The content of the main components is usually in the range,%: Si ₂ - 47-50.5; Al ₂ O ₃ - 5-10; Fe ₂ O ₃ - 15-22; FeO - 2-4; MgO - 3-4; CaO - 0-0.8; Na ₂ O - 0-0.5; K ₂ O - 6-8; H ₂ O - 7-9. Fluctuations in composition are associated with isomorphic substitutions.

The bioavailability (digestibility) of useful substances (vitamins, amino acids, proteins, carbohydrates, trace elements) contained in the product (preparation) is determined by the degree of assimilation (absorption) of these substances by the body through the gastrointestinal tract. Various factors can influence the bioavailability of substances, in particular dissolution rate these substances. It is known that the dissolution rate of substances contained in the particles of a product (preparation) increases with an increase in their surface area, i.e., with a decrease in particle size. Thus, the particle size of the powdery product obtained by the proposed technology in the range of 0.1-30.0 μm in comparison with the particle size of 100-250 μm in products prepared in accordance with similar technologies increases the bioavailability of useful substances and the digestibility of the powdery product (drug).

In accordance with the above, the set of essential features of the proposed ultrafine powder from antlers, the technology for its preparation, elixir and a solution for balneotherapy based on ultrafine powder in comparison with the set of essential features of the known technical solutions-analogues meets the criteria of "novelty" and "inventive step".

Examples of carrying out the invention

The technology of obtaining ultrafine powder from antlers Example 1. First, the wool cover is mechanically removed from antlers of red deer, red deer or sika deer. The antlers are dried in air, crushed in a crusher to a particle size of 5-10 mm and dried with an air stream with a temperature of 60-70 ⁰ C. Then the material is re-crushed by rolling to an average particle size of 100 μm and re-dried with an air stream at the same temperature. An abrasive powder with a particle size of 1.0-50.0 μm in an amount of 20% by weight of the material being ground is introduced into the obtained product. As an abrasive powder, a mixture of salt additives with a sorbent zeolite taken in a ratio of 1: 1 with a particle size of not more than 150 microns is used and thoroughly mixed. Moreover, the abrasive powder mixture is pre-dried to a residual moisture content of not more than 3 wt ₌ %. Further grinding is carried out by means of a vortex mill developed by the company "Vortex Technologies", Novosibirsk (RU, Cl ₅ 2057588, 04/10/1996). The vortex mill is a gas dynamic grinder, using the energy of compressed air to accelerate the crushed particles of the product in a vortex flow. In a vortex mill serves a mixture of the processed material from antlers and abrasive powder in the specified ratio. The mixture, falling into the turbulent air flow, accelerates and is subjected to gas-dynamic effects. Particles of the processed material are additionally contacted with particles of abrasive powder, which contribute to finer crushing of the material, at the same time reduce its residual moisture due to the presence of zeolite in the sorbent mixture. Static electricity does not accumulate due to the presence in the stream of particles of zeolite, regulating the moisture content of the material. The diameter of the particles obtained by grinding is less than 30 microns. As a result of this treatment, the mechanochemical activation of the material occurs and its physicochemical properties change. The abrasive crystalline component of this mixture (salt additives) allows you to achieve a uniform distribution of destructive forces ("ydapa") applied to destructible antler material in a vortex mill. An admixture of a natural sorbent (zeolite) is a dry source of water molecules, which makes it possible to simultaneously provide conditions for a quasi-hydrothermal soft grinding regime and to prevent local overheating and the formation of peroxide and radical products in the reaction mixture. The product is ground without significant heating and structural changes in the material, as a result of which the biological activity of the vitamins, amino acids, and microelements contained in the product is retained with the production of particles from 30.0 to 0.1 μm (submicron particles) and a moisture content of not more than 3 wt.%. After grinding, the finished powdery product is Packed in vacuum packaging.

Example 2. The technology for preparing ultrafine powder from antlers to the stage of feeding into a vortex mill is similar to Example 1. An abrasive powder with a particle size of 1.0-50.0 μm in a ratio of 1: 1 is introduced into the crushed product to an average particle size of 100 μm and mixed thoroughly . As an abrasive powder, a mixture of salt additives with a sorbent zeolite taken in a ratio of 5: 1 with a particle size of not more than 150 microns is used and thoroughly mixed. Moreover, the abrasive powder mixture is pre-dried to a residual moisture content of not more than 3 wt.%. In a vortex mill serves a mixture of the processed material from antlers and abrasive powder in the specified ratio. The mixture, falling into the turbulent air flow, accelerates and is subjected to gas-dynamic effects. At the same time, the process of grinding the product in a vortex mill is carried out in a vibroacoustic field with a frequency from 30 to 300 Hz and an amplitude of oscillations from 1.0-20.0 μm, which is created by an acoustic vibrator installed in the mill body. The particles of the processed material are in contact with the particles of abrasive powder, which make in the flow movement (oscillation) with an amplitude of 1-20 μm, which contributes to a finer crushing of the material. Particles of abrasive powder at the same time reduce the residual moisture of the crushed material. The product is ground without significant heating and structural changes in the material; as a result, the biological activity of the vitamins, amino acids, and microelements contained in the product is retained, with particles from 30.0 to OD microns (submicron particles) and humidity not exceeding 3 wt.%. After grinding the material from the antlers, the finished powdery product is Packed in vacuum packaging. The grinding time of the product in the second example compared with the first is reduced by 2-2.5 times.

The following are examples (3 - 5) of the composition of the ultrafine powder from antlers obtained in accordance with examples 1 or 2. Example 3. The composition of the ultrafine powder (May.%): Zeolite 5.0 sodium chloride 15.0 ultrafine powder from the antlers the rest to one hundred%

Example 4. The composition of the ultrafine powder (May.%): Zeolite 15.0 sodium chloride 35.0 ultrafine antler powder, the rest is up to 100%

Example 5. The composition of the ultrafine powder (May.%): Zeolite 7.0 sea salt 35.0 ultrafine powder from antlers the rest up to 100%

Assessment of the bioavailability of substances contained in ultrafine powder from antlers made by the proposed method

The bioavailability of the substances contained in the ultrafine antler powder manufactured by the proposed technology was evaluated by the rate of extraction of the substances in an aqueous solution of ethyl alcohol. As a comparison, we took the prototype technology for producing powder from antlers with a particle size of 0.1 to 30 microns, described in the description of the invention to RF patent Zh2146525. The evaluation methodology was carried out in accordance with FC-42-2323-85. In accordance with the methodology, the studied powder products (claimed and control) are placed in extractors with activators, filled with a 70% aqueous solution of ethyl alcohol and extracted with continuous stirring.

The results of checking the bioavailability of the drug according to the proposed technology show that the extractability of substances from powdered preparations made by the claimed method is the same as in the preparation made in accordance with the prototype technology according to the patent of the Russian Federation N ° 2146525, which confirms the high bioavailability of substances in powder from antlers obtained by the proposed technology.

The study of the carbon isotopic composition in ultrafine antler powder and the content of labile substances in it

Studies of the carbon isotopic composition,

antler powder made by the claimed technology, made by mass spectrometry, electron impact. The sample was heat treated at t 650 ⁰ C in an atmosphere of pure oxygen. The measurements were carried out according to the peaks of CO _2. Atmospheric CO _{2 was} used as a reference.

Preliminary data showed that the isotopic composition of carbon (C ¹² ) is from 98.53 to 98.7%; (C ¹³ ) from 1.3 to 1.47% while the reference value

10 1 ^* ϊ of atmospheric air of the laboratory corresponds to (C) 98.9%; (C) 1.1% and is close to the natural composition.

Experimental studies have shown the beneficial effect of the non-radioactive C ¹³ carbon isotope on body cells (Kaznacheev V.P., Rzhavin A.F., Mikhailova L.P. On the issue of thermonuclear bioenergetics of living matter // International Symposium "Cold Nuclear Fusion and New Energy Sources" )) (May 24-26, 1994) .- Minsk, 1994.- p. 190-195). With age or under the influence of adverse environmental conditions (the Far North, the Arctic, difficult working conditions), irreversible changes in the cells of human tissue structures occur due to a decrease or disappearance of the carbon isotope 13, “responsible” from the cells (for the reasons listed above), in the body youth and cell health. A person begins to weaken very quickly, grow old and often get sick. With the help of antler baths, antler cosmetics, C ¹³ isotopes penetrate the cells of the whole body through the skin and subcutaneous tissue, improving its general condition, enhancing protective functions, restoring energy, health and ensuring longevity.

Proteins in the ultrafine powder obtained by the claimed method and the prototype method were determined by chromatographic method, vitamins were determined by high performance liquid chromatography with the appropriate standards, and hormone content was determined by radioimmunoassay (steroids were extracted from the powder with diethyl ether before determination). Table 1

Comparative data on the content of labile substances in ultrafine powder from antlers, prepared by the prototype method and the claimed method

Analysis of table 1 shows that the inventive method for producing ultradisperse powder from antlers provides milder grinding conditions, as a result of which the content of such labile substances as globulins, vitamins and hormones is much higher than in a similar product obtained by the prototype method.

The following is the technology for the preparation of food additives or pharmaceutical preparations in dry form based on ultrafine powder of antlers.

Example 6. Preparation of food additives or pharmaceutical preparations. Nutritional supplements or pharmaceutical preparations in dry form. LϊрϊϊГGТпВЛПΞαϊGТ В ϊIGрОIПIv ОВОИvI СIvIССИТСЛС. СϊvIССИТСЛПсДГТάВЛЯсi υϋυϋй capacity with a spherical bottom having an axis of rotation inclined to the horizontal. The mixing efficiency is ensured by inert bodies of a spherical shape, significantly smaller than that of the bottom of the tank of radius curvature, and significantly greater specific gravity than the specific gravity of the mixed components of the material. Inert bodies prevent aggregation of particles and provide mixing with particles of any dispersion in a small gap between the surface of inert bodies and the bottom of the tank. The number of inert bodies ensures their location in only one layer to avoid their active collision and, as a result, to avoid overheating of the mixed materials.

The following components of the pharmaceutical preparation (wt.%) Are introduced into the specified mixer: ultrafine antler powder obtained in Example 3 15.0-35.0 plant extracts, for example, Rhodiola rosea 1.0-3.0 glucose, rest up to 100%

Or components of a food additive (wt.%): Ultrafine antler powder obtained in Example 4 0.5-5.0 powder from cereal sprouts 1, 0-10.0 powdered sugar 15.0-25.0 milk powder the rest up to 100%

The components are mixed in the specified powder mixer for 25-30 minutes and packaged in a sealed disposable package.

Example 7. Preparation of cosmetics

In the manufacture of the drug, simple technological equipment is used, equipped with a reactor with a stirrer.

To prepare the cream, the gel base is loaded into the stirred reactor at a temperature of + (18-2O) ⁰ C and the components are added with stirring according to the recipe below (May): ultrafine antler powder obtained in Example 5 1.0-2.0 nutritious additives of animal origin 0.5-1.0 bacteriostatic substances of plant origin no more than 20.0 gel base rest up to 100%

The components are mixed for 20-30 minutes and the pH of the mixture is measured. If the pH of the mixture is below 7.2 (the gel has an acidic environment), then a phosphate-salt additive (Na ₂ HPO ₄ x 12H ₂ O) is added to the composition in an amount sufficient to maintain a pH of 7.2. Then the mixture is homogenized again in the reactor for 20-30 minutes, the finished cosmetic product is packaged in a container and stored at a temperature of +7 ⁰ C. The cold method of preparing the cream allows you to maximize the activity of its constituent components.

The following are examples of EXCIRUS elixir formulations for bathtubs with different volumes of water.

Example 8. Elixir "EXCIRUS" for therapeutic baths (wt.%): Ultrafine antler powder obtained in example 3 5.0 alcohol 35.0 water the rest up to 100%.

Example 9. Elixir "EXCIRUS" for therapeutic baths (wt.%): Ultrafine antler powder obtained in example 4 1.0 alcohol 40.0 fir oil 0.1 water, the rest up to 100%.

Example 10. Elixir "EXCIRUS" for therapeutic baths (wt.%): Ultrafine antler powder obtained in example 5 10.0 alcohol 45.0 phytoextracts 5.0

(extracts of motherwort grass, cinnamon grass, rosemary and hawthorn flowers in a ratio of 9: 3: 2: 1, respectively) water the rest is up to 100%.

The following are examples of the composition of the solution based on the elixir "EXCIRUS". Example 11. The solution of the elixir "EXCIRUS" for therapeutic baths (May.%): The elixir EXCIRUS "for baths obtained in example 8 0.0001 water the rest up to 100%

This solution in homeopathic doses is recommended for patients with hypertension of varying severity. Example 12. The solution of the elixir "EXCIRUS" for therapeutic baths (May.%): The elixir "EXCIRUS" for baths obtained according to example 9 or 10 0.07 water the rest up to 100%

The study of the solution of the elixir "EXCIRUS" for therapeutic baths by bioindication

The inventive solution from the elixir "EXCIRUS" based on ultrafine powder from antlers (not ossified antlers of deer (Servus sarhus sibiricus), sika deer (Servus pirrop hornofilosh SW and reindeer) was studied using bioinduction-based cell culture 2 cell culture growth, mitotic activity of the cell monolayer.

Cell suspension with a cell concentration of 80 thousand cells / ml of culture medium was seated in penicillin vials with coverslips at the bottom of the vial. The culture medium used was Eagle's medium, a lactalbumin hydrolyzate supplemented with 10% cattle serum. After the formation of the cell monolayer, the culture medium was merged and replaced with a solution of elixir "EXCIRUS" in the environment of the Needle. The control was culture medium without the addition of the drug.

The drug was tested at a concentration of 0.5 mg / L, 0.1 mg / L, 0.01 mg / L, 0.001 mg / L and 0.0001 mg / ml. Vials with the culture medium Needle were incubated in a thermostat at t = 37 ° C for 72 hours. Every 24 hours morphological preparations were prepared according to the generally accepted methodology and the total number of cells was calculated by random fields using the Stefanov SB morphological grid. The resulting materials are shown in table 2.

Table 2 The results of the study of the solution of the elixir by bioindication

Table 2 shows that the drug at a concentration of 0.5 mg / L, 0.1 mg / L - is toxic, a dose of 0.001 mg / L - has some stimulating effect on the growth of cell culture, mitotic activity is much higher than in the control culture. There are no pathological mitoses. The solution at a concentration of 0.0001 mg / l (dilution 1: 10000) is active 1.5-1.7 times, with a sufficiently high mitosis. From this we can conclude that with large dilutions of the drug (1000 times) used in the experiment, its biological activity is significantly higher than with small dilutions. The technique of taking restoring medicinal baths using the elixir “EXCIRUS”.

1. Fill the bath (100-150 liters) with warm water, t = 36-38 degrees Celsius.

2. Take the elixir "EXCIRUS", packed in a bottle and shake the contents several times.

3. The EXCIRUS elixir is poured from the vial into the bath, the water is gently stirred. In the bottle, a thick part of the EXCIRUS elixir may remain. It is recommended that you fill the vial with the solution from the bathtub and pour the contents back into the bathtub. The composition of the bath corresponds to examples 12 or 13 of the present description.

4. Fill a jug or other vessel, with a capacity of 1 to 3 liters, with an EXCIRUS elixir solution from the bath, close the lid, and put in the refrigerator. To rejuvenate the skin of the face and neck, a daily contrast wash is done alternately with hot water and a cold solution of elixir.

5. Immerse yourself in the bath for 10-15 minutes. If you wish, you can wet your hair or briefly immerse yourself in the bath with your head, eyes closed. In case of contact with eyes, rinse with clean warm water. After the procedure is completed, the body is not rinsed, but only blotted with a sheet or towel, and the hair is dried with a towel. It is advisable to take water procedures no earlier than 2 hours after taking a bath.

6. After the bath, they rest for 30-40 minutes with calm, relaxing music. You can drink tea, preferably with honey. The recovery course using the EXCIRUS elixir consists of nine such procedures according to the following scheme: five daily procedures using the EXCIRC elixir bottles; two-day break; two daily procedures using vials with EXCIRUS elixir; a two-day break during which the patient begins to enjoy the sensation of the growing capabilities of his body; two daily procedures using bottles with EXCIRUS elixir.

The frequency of the recovery course is determined by the general condition of the patient’s body, but should not be more often than once every six months. It is recommended that the elixir be stored at room temperature in a dark place.

The positive effect of bathtubs with the EXIRUS elixir on the aging processes of the body and its rejuvenation, restoration and strengthening of male and female sexual capabilities, increased mental and physical performance has been confirmed by the Russian Scientific Center for Restorative Medicine and Balneology of the Ministry of Health of Russia. The thousand-year experience of using antlers and preparations from them did not reveal contraindications, except for severe forms of hypertension. Restorative baths with elixir "EXCIRUS" are also recommended:

• after severe illnesses, with asthenic conditions;

• to improve the condition of patients with atherosclerosis, coronary heart disease, with impaired peripheral circulation, with age-related changes in muscles, bones and joints (osteochondrosis, arthrosis);

• to accelerate the healing process of wounds, connective tissue, muscle growth;

• to enhance the protective functions of the immune system and the body as a whole;

• to improve the functioning of the genitourinary system (the fight against prostatitis, uterine myoma, salpingo-oophoritis);

^ to improve the condition of patients with stress-dependent diseases (neurosis, neurasthenia, peptic ulcer, cardiovascular disease, sex neurosis); • to normalize sleep.

The results of the treatment of chronic dermatoses

The study was conducted in three patients with psoriasis. Two patients underwent a course of balneotherapy using bathtubs prepared on the basis of the EXCIRUS elixir, and the third patient took oxygen baths. The course consisted of 5 baths for all studied, the duration of each procedure is 15-20 minutes. The effectiveness of therapy was evaluated on the basis of the dynamics of clinical manifestations with the assessment of the disappearance of hyperemia, infiltration, edema, peeling, itching in three grades: clinical recovery, significant improvement, lack of effect. As a result of balneotherapy using the inventive solution based on the elixir “EXCIRUS”, the first two patients showed a significant improvement, the third patient had a slight effect from the use of bathtubs.

Studies show that the inventive ultrafine powder from antlers and the technology for its preparation allows preserving all biologically active properties of valuable raw materials in the finished product, makes it possible to manufacture new products (medicines, shampoos, lotions, creams, food additives, antler baths, etc.) with high therapeutic effect. Pills can be pressed from the powder, which are easily absorbed by the human body, and, according to experimental data, surpass the healing properties of pantocrine.

Industrial applicability

The proposed technology and preparations in dry and liquid form can be implemented both in the conditions of large food or pharmaceutical plants, and in the workshops of small companies that have the appropriate equipment.

Claims

Claim

1. Ultrafine powder from antlers with a particle size of 0.1-30.0 μm, characterized in that the ultrafine powder from antlers in its structure has a non-radioactive carbon isotope C ¹³ in quantities of not less than 1.3% of the carbon content in the finished product, received in accordance with p.p. 3-6 of the present claims and additionally contains a sorbent and salt additives with the following content of components (wt.%): Sorbent 5.0-15.0 salt additives 15.0-35.0 ultrafine powder from antlers the rest up to 100%

2. The ultrafine powder from antlers according to claim 1, characterized in that it contains zeolite as a sorbent, and sodium chloride or sea salt as salt additives.

3. A method of producing ultrafine powder from antlers, including mechanical removal of wool from antlers of reindeer or sika deer, deer or deer, crushing the material to a particle size of 5-10 mm and drying it with an air stream with a temperature of not more than 7O ⁰ C, repeated grinding of the material to an average particle size of OD mm and re-drying it with an air stream at the same temperature, introducing into the obtained product with simultaneous stirring an abrasive powder with a residual moisture content of not more than 3 wt.% in quantity nom for effective crushing of the product, grinding the resulting mixture in a vortex mill in the presence of the specified abrasive powder to obtain ultrafine material from antlers with a particle size of 0.1-30 μm and a moisture content of not more than 3 wt.%, followed by packing the finished powder product in a vacuum package, characterized in that a mixture of salt additives with a sorbent taken in a ratio of 1: 1 to 5: 1 with a particle size of not more than 150 microns is used as an abrasive powder in an amount of at least 20% by weight of the material being ground m, and the finished ultrafine powder from antlers in its structure contains a non-radioactive carbon isotope C in an amount of not less than 1.3% of the carbon content in the finished product.

4. The method according to p. 3, characterized in that as the salt additives use sodium chloride or sea salt.

5. The method according to 3, characterized in that the zeolite is used as the sorbent.

6. The method according to p. 3, characterized in that when grinding the product in a vortex mill, the flow of the mixture of the product with the abrasive powder is additionally exposed to a vibro-acoustic field with a frequency of 30-300 Hz and an oscillation amplitude of 1.0-20.0 μm.

7. Elixir for therapeutic baths, including a water-alcohol extract from crushed antlers, characterized in that as crushed antlers it contains an ultrafine powder from antlers with a particle size of 0.1-30.0 microns, obtained in accordance with 3-6 of the present claims, with the following content of components (wt.%): Ultrafine powder from antlers 1, 0-10.0 alcohol 35.0-45.0 water, the rest is up to 100%.

8. The elixir for therapeutic baths, according to claim 7, characterized in that it additionally contains phytoextracts in an amount of 0.1-5.0% by weight of the elixir.

9. The elixir for therapeutic baths according to claim 8, characterized in that it contains fir oil as phytoextracts.

10. The elixir for medicinal baths according to claim 8, characterized in that it contains extracts of motherwort herb, cinnamon grass, rosemary herb and hawthorn flowers in phytoextracts in a ratio of 9: 3: 2: 1, respectively.