JPH09315987A - Utilization of awamori as antiallergic active ingredient - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a food, a medicine (a quasi-drug) or a cosmetic, comprising Awamori (a traditional distilled alcoholic beverage of Okinawa islands in Japan) as an antiallergic active ingredient, having excellent antiallergic actions without any adverse effects such as sleepiness, pharyngoxerotic feeling and deterioration in visual acuity and useful for preventing and treating allergic diseases. SOLUTION: This food, medicine, quasi-drug or cosmetic comprises (A) Awamori [e.g. an old Sake prepared by charging a Koji (a fungus), having a strong acid taste and growing a black Koji-mold such as Aspergillus awamori or Aspergillus kawachii on a steamed rice obtained by milling a nonglutinous rice of Indica type rice such as Thai rice or japonica rice and steaming the milled rice and water into a container, simultaneously carrying out the saccarification and alcoholic fermentation with a yeast of the Awamori, then passing the resultant product through distillation, etc., and storing and aging the prepared liquor for 3-10 years, especially 3-6 years] as an antiallergic active ingredient.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to foods, pharmaceuticals, quasi drugs, and cosmetics containing awamori as an antiallergic active ingredient.

[0002]

2. Description of the Related Art Allergies that cause allergic diseases are roughly classified into the following four types I to IV. Type I allergies (immediate allergies) are those that develop in a relatively short time due to re-invasion of the antigen, and hay fever, allergic rhinitis, atopic dermatitis, asthma, urticaria, eczema, gastrointestinal allergy, etc. This is due to this reaction. Type II allergy (cytotoxic hypersensitivity reaction) is a reaction that is induced by binding of an antibody to an antigen present on the cell surface layer, which is a side effect that occurs during blood group incompatibility during transfusion and systemic lupus erythematosus. (SLE) is a major cause of autoimmune diseases. II
Type I allergy is an acute inflammation that occurs when the antigen-antibody complex precipitates in vivo and deposits on the blood vessel wall several hours or days after the invasion of the antigen into the body, where complement activation activates. Say. Type IV allergy (delayed hypersensitivity reaction)
When the immunized individual is re-administered with the antigen,
After 48 hours, it means an inflammatory reaction with induration that reaches the maximum, and examples thereof include tuberculin reaction and graft rejection reaction.

Among these four types of allergies, those classified as type I allergies have been significantly increasing in recent years, and this tendency is due to air pollution and changes in dietary habits (for example, in the body due to excessive intake of linoleic acid). It is believed that this is caused by a change in the living environment caused by the imbalance of fatty acids) and various synthetic compounds that are often used in pharmaceuticals and cosmetics and are often taken into contact with the human body or come into contact with them. The causative agent that causes allergic symptoms is called an allergen. Pollens such as cedar, cypress, birch, ragweed, and barley are airborne pollen allergens that cause hay fever. Among these pollen allergens, cedar, which has become a serious social problem, has symptoms of allergic conjunctivitis such as itchy eyes, pain and redness, sneezing and stuffy nose, and runny nose. It is also said to be 10 million.

For the development of type I allergy, including hay fever
The gE antibody (immunoglobulin E) plays an important role. The onset mechanism of type I allergy can be broadly divided into the following three stages. First step: The allergen invading the human body is taken up by antigen-presenting cells such as macrophages and decomposed into peptides. Part of this peptide (an epitope recognized by T cells) forms a complex with its own MHC protein,
It transmits its antigenicity to cells and activates T cells. Activated T cells release various cytokines, and these cytokines act on B cells to promote B cell differentiation and proliferation, and produce allergen-specific IgE antibodies. The produced IgE antibody binds to the IgE receptor present on the cell surface of the target cells, mast cells present in the skin and mucous membranes and basophils present in peripheral blood, to establish a sensitized state. Second step: The re-invaded allergen binds to two or more molecules of IgE antibody on the surface of the sensitized cell and forms a crosslinked structure via the allergen. The formation of this crosslinked structure triggers release of chemical mediators such as histamine, which is contained in large amounts in mast cells and basophils, and leukotriene [metabolite of arachidonic acid (an unsaturated fatty acid having 20 carbon atoms) by lipoxygenase]. . Third stage: These released chemical messengers cause contraction of smooth muscle and increase in capillary permeability, and the various allergic symptoms described above are developed. The onset of allergic symptom itself is a defense reaction of the body from the viewpoint of preventing the invasion of the antigen into the whole body and eliminating the antigen, even if a locally impaired lesion caused by invasion of the antigen (bacteria, virus, etc.) occurs. Is a manifestation of. However, recently, the number of people who complain of local or systemic allergic diseases has greatly increased.

Synthetic compounds have already been used as active ingredients of antiallergic agents, and synthetic compounds having various antiallergic actions have been proposed at present. However, some of the currently used anti-allergic agents have side effects such as drowsiness, dryness of the throat, and decreased visual acuity, and their properties are well known, especially when they are used in over-the-counter drugs. Since it is difficult to say that it is present, it may cause inconvenience in use. On the other hand, efforts to find an antiallergic active ingredient from a plant or its extract have been energetically made, and various proposals have already been made. For example, there are the following proposals. An extract of immature Unshiu mandarin (Japanese Patent Application Laid-Open No. 63-170323). Extract of tencha (Japanese tea) (JP-A-6-192114). Turmeric extract (JP-A-6-211713). Extracts of Cyperaceae (JP-A-7-
53359 publication). Extract of rice (JP-A-7-252158). Comfrey extract (JP-A-7-278001).
A mixture of α-linolenic acid-containing sesame oil and sesamin-containing sesame oil (JP-A-4-290822). Evening primrose oil containing γ-linolenic acid (JP-A-5-68506). Shochu extract of Japanese armored crane (Tokyo Yomiuri Shimbun morning edition Sunday May 24, 1987 7
surface). Rose shochu extract (JP-A-4-108708). However, even now, proposals for new active ingredients having preventive and therapeutic effects on allergic diseases are still eagerly desired.

[0006]

Therefore, the present inventors have found out an antiallergic active ingredient from foods which are well known for their properties and which are ingested on a daily basis. It was an object to provide foods, pharmaceuticals, quasi-drugs, and cosmetics as active ingredients.

[0007]

Means for Solving the Problems As a result of earnest efforts, the present inventors have found that awamori can be used as an antiallergic active ingredient, and that foods, pharmaceuticals, quasi drugs, and quasi-drugs containing awamori as an antiallergic active ingredient can be used. , Came to propose cosmetics. The present invention is thus completed.

Therefore, the present invention has the following structural features. The first invention relates to a food containing awamori as an antiallergic active ingredient. The second invention relates to a medicine containing awamori as an antiallergic active ingredient. The third invention relates to a quasi drug containing awamori as an antiallergic active ingredient. 4th
The present invention relates to cosmetics containing awamori as an antiallergic active ingredient.

Hereinafter, the present invention will be described in detail. Awamori used as an active ingredient in the present invention is rice shochu specially produced in Okinawa, which is positioned as the prototype of Moromitori shochu, in which steamed rice is produced with black koji mold (awamori fungus) and strong acidity koji and water. It is manufactured by a well-established method in which a container is charged, alcoholic fermentation with yeast is performed at the same time as saccharification, and then several steps including distillation are performed. Therefore, awamori is an alcoholic beverage that can be stably obtained, and there is no problem in using it as the antiallergic active ingredient of the present invention. The rice for steaming rice to be used is usually Indica rice such as Thai rice, or the moisturizing of Japonica rice, which is used after milling. Examples of Aspergillus niger used include Aspergillus awamori (a kind of Aspergillus niger) and Aspergillus kawachi (a mutant of Aspergillus niger, a kind of Aspergillus niger). As the yeast, a yeast group called Awamori yeast is usually used. This group includes Awamori No. 1 yeast, whose mycological properties have been well studied. When the aged primary mash that has been subjected to alcohol fermentation is distilled with a simple single-distiller, the alcohol content is 45 degrees [degree is the unit used for alcoholic beverages and corresponds to volume%. Chemistry Handbook Basic Edition II (Maruzen, 19
According to the concentration of ethanol in Table 5.42 on page 463, pp. 463, the temperature at 15.56 ° C is 45% at 38%. ] You can get the original sake. In the following, in order to distinguish this original sake and its water dilution from old sake, it is referred to as new sake.

According to the traditional method, this sake is packed with turtles and wrapped in leaves of Itoshosho. Deiko (Fabaceae plant)
3 to 15 years, usually 3 to 15 years, usually 3 to 15 years after sealing with a wooden stopper, and in a recent method, sealing in a closed container such as a stainless tank, an enameled tank, a barrel, a bottle, etc.
After aging for about 10 years, awamori called old sake, which is superior to fresh sake in color, taste and aroma, is completed. Water is added to this aged storage product, and the alcohol content is 40, 35,
It is easily available as a product prepared for products at 30 and 25 degrees. Academic research is being conducted to clarify the differences in the color, taste, and aroma between old and new sake. For example, during aging, chemical changes in flavor components under oxidative conditions and physical changes in the interaction between ethanol molecules and water molecules [Fermentation Engineering Journal, Vol. 69, No. 4, 237-2].
52 (1991)] and increase of caprylic acid (same as octanoic acid) and lauric acid (same as dodecanoic acid) [Fermentation Engineering Journal, Volume 64, No. 1, 9-15 (1986)].
There are reports about the above.

Awamori is well known in its properties as an alcoholic beverage, and if used according to its well known properties, it can be advantageously used for the purpose of the present invention. Awamori used as an active ingredient in the present invention is new liquor, old liquor, and awamori located in the middle thereof, a mixture of fresh liquor and old liquor, and any awamori can be used, but it is preferable. Is about 3 to 10 years, more preferably,
Use old sake that has been stored and aged for about 3 to 6 years. At the time of use, Awamori can be used after diluting it with water or by removing a part of water and / or ethanol with a molecular sieve (molecular sieve). Further, a chemical bond type packing material used for liquid chromatography [for example, a packing material in which octadecylsilyl group is bonded to the surface of silica gel. Among them, Seppak C18 is included], and awamori treated by removing a part of water and / or ethanol can be used as an antiallergic active ingredient.

Of course, awamori can be directly consumed as an alcoholic beverage as an antiallergic active ingredient. Further, it can be advantageously used for various compositions such as foods, pharmaceuticals, quasi drugs, cosmetics and the like. Examples of foods containing awamori as an antiallergic active ingredient include the following. Sweet, mochi, manju,
Uiro, bean paste, yokan, mizuyo, jelly, starch syrup and other semi-liquid candy, and various Japanese sweets such as candy. Western sweets such as pudding, butter cream, custard cream, cream puff, waffles, bonbons, liqueur sponges. Ice cream, sherbet and other frozen desserts. Syrups such as pickled fruits and ice honey. Pastes such as flower paste, peanut paste, fruit paste and spreads. jam. marmalade. Fruits such as syrup pickles. Processed foods of vegetables. Fukugami-zuke, Betara-zuke, Senmai-zuke,
Pickles such as rakkyo pickles. Meat products such as ham and sausage. Fish products such as fish ham, fish sausage, kamaboko, chikuwa, and tempura. Various delicacies such as sea urchin, salted squid, and vinegar kelp. Tsukudani stew made from seaweed, wild vegetables, sardines, small fish and shellfish. Prepared foods such as boiled beans, potato salad, and kelp rolls. Various seasonings such as nanban vinegar and yakiniku sauce. Dairy products such as milk drinks, yogurt and cheese. Bottled and canned fish, meat, fruits and vegetables. Liquors such as liqueurs. Beverages such as coffee, tea, juice, whey drinks, carbonated drinks, lactic acid drinks and lactic acid bacteria drinks. Furthermore, various foods and drinks such as baby foods, therapeutic foods and drinks.

The drug containing awamori as an antiallergic active ingredient can be used as an oral preparation or a parenteral preparation. Parenteral agents may be agents for direct use on the organ or external preparations. Examples of oral preparations include the following preparations. Extract, emulsion, elixir, capsule, syrup, soft capsule, microcapsule, solution, suspension, emulsion, flow extract. Parenteral preparations include nasal drops, eye drops, ear drops, inserts (nose, ear), olfactory agents (= snuff agents, inhalants; nose, throat, bronchi), injections (intravenous, subcutaneous, intramuscular). ,
Transdermal, intrarectal) and suppositories (vaginal, rectal, anus) direct use on organs, external use, or both. You can also Examples of the parenteral preparations include the following preparations. Aerosol, emulsion, capsule, cream, gel, spray, jelly, tincture, pasta, paste, liniment, lotion, solution, suspension, salve, patch, ointment Agents, emulsions, sprays.

The active ingredient of the present invention can be used by adding it to a quasi drug as an active ingredient. Formulations used for hair include shampoo, conditioner, hair treatment, hair growth,
There are hair cosmetics such as hair nourishing agents (hair essence agents, hair tonics, hair styling agents), and oils. The dosage form of the oral composition includes gargling and toothpaste. Dosage forms used for bath include bath salts and body soaps. Further, it can be carried on a wet tissue.

The active ingredient of the present invention can also be used by adding it to cosmetics as an active ingredient. Cosmetic formulations include lotions, emulsions, creams, lotions, facial cleansers, skin cleansers, cleansing creams, packs, cosmetic creams, ointments and the like.

Awamori, which is the active ingredient of the present invention, can be used as it is as a composition used in these foods, pharmaceuticals, quasi drugs, and cosmetics. Furthermore, it can be used as a composition containing a substance that exerts the effect more reliably additively or synergistically without impairing the effect of the active ingredient according to the present invention. The substances that support the manifestation of these effects can be classified according to the purpose of use in the composition, and the following can be exemplified. pH
Regulators, gel bases, vehicles, stabilizers, liquid carriers, solubilizers, surfactants, lubricants, sweeteners, buffers, absorption enhancers, flavoring agents, flavoring agents, flavoring agents, binders, Suspending agent, antioxidant, flavoring agent, fragrance, polymer thickener, solid carrier, bactericide, antioxidant, ultraviolet absorber, wetting agent, lubricant, pigment, hydrophilic base, water-soluble group Agent, refreshing agent, hydrophobic base,
Compatibilizer, thickener, extender, carrier, flavoring agent, colorant, additive, tonicity agent, ointment base, emulsifier, emulsion base, coating agent, excipient, flavoring agent, dispersant , Propellant, humectant, preservative, auxiliary agent, disintegrant, disintegration aid, disintegration inhibitor, swelling agent,
Antiseptic / bactericidal agent, antiseptic agent, soothing agent, oily base, solubilizing agent, solvent, fluidity promoter.

In the constituent components of the composition, individual substances included in each classification according to the purpose of use can be classified according to their chemical structure, physicochemical properties, their origin of origin, or purpose of use. Such a thing can be illustrated. As is clear from the overlap in the examples, these exemplified substances are substances that can be used for different purposes in different compositions. In addition, it is needless to say that the overlapping of the purpose of use of the constituent components in the composition of the present invention is not limited to the overlapping in the examples. water. For example, water having the following contents can be used. Isotonic solutions containing glucose and other adjuvants (eg D-sorbitol,
D-mannitol, sodium chloride, etc., glucose aqueous solution, various buffer solutions, distilled water, physiological saline, purified water, electrolyte solution, sterilized water, sterilized purified water, infusion solution. Examples of fats and oils include the following. Almond oil, avocado oil, fennel oil, perilla oil, olive oil, orange laffer oil, orange oil, cacao butter, chamomile oil, carrot oil, cucumber oil, coconut oil, sesame oil, southern oil, safflower oil, turtle oil,
Camellia oil, corn oil, rapeseed oil, persic oil,
Palm kernel oil, palm oil, castor oil, jojoba oil, mink oil, mrow, coconut oil, rosehip oil, beef tallow, evening primrose oil, hydrogenated palm oil, hydrogenated castor oil, hydrogenated coconut oil, soybean oil, pork fat, horse oil and fat , Cottonseed oil, peanut oil, egg yolk oil.

Examples of waxes include the following. Carnauba wax, candelilla wax, cholesterol, silicone, squalane, shellac wax, ceresin, paraffin, paraffin wax, plastibase, microcrystalline wax, beeswax, mrow, montan wax, lanolin, vaseline, wax, liquid paraffin, liquid lanolin, reduced lanolin, whale wax,
Solid paraffin, hard lanolin, higher hydrocarbons, white petrolatum, liquid paraffin.

As the mineral oil, the following can be exemplified. Ozokeride, ceresin, paraffin, pristane, polyethylene powder, microcrystalline wax, petrolatum, liquid paraffin. Examples of fatty acids include the following. 12-
Hydroxystearic acid, 2-ethylbutanoic acid, 2-ethylhexanoic acid, 2-methylpentanoic acid, isononanoic acid, isopentanoic acid, undecylenic acid, oleic acid, caproic acid, stearic acid, tall oil, palmitic acid, palmitoleic acid, behenic acid. , Behenic acid, myristic acid, lauric acid, lanolin fatty acid, linoleic acid, linolenic acid (α-linolenic acid, γ-linolenic acid).

Examples of alcohols include the following. 2-octyldodecanol, 2
Hexyldecanol, isostearyl alcohol, isopropanol, ethanol, oleyl alcohol, cholesterol, stearyl alcohol, cetanol, cetyl alcohol, phytosterols, methanol, lauryl alcohol, lanolin alcohol. Examples of the polyhydric alcohols include the following.
1,3-butylene glycol, arabinose, isomaltooligosaccharide, inositol, ethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, galactose, xylitol, xylose, xylooligosaccharide, glycerin, corn syrup, cyclodextrin (α-cyclodextrin) , Β-cyclodextrin, γ-cyclodextrin), sucrose, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monomethyl ether, dipropylene glycol, stevioside, cellobiose, sorbitol, dextrins,
Starch, triethylene glycol, trehalose (α, α-trehalose), batyl alcohol, palatinose, fructooligosaccharides, glucose, propylene glycol, pentaerythritol, polyethylene glycol, polyvinyl alcohol, polypropylene glycol, maltose, mannitol, mannose, raffinose, rubusoside, Fructose, lactose.

Examples of the esters include the following. Diisopropyl adipate, ethyl oleate, oleyl oleate, decyl oleate, ethyl caproate, glycerin monostearate (monoglyceride stearate), propylene glycol dioleate, hexyldecyl dimethyloctanoate,
Butyl stearate, diethyl sebacate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monooleate, sorbitan monostearate, isopropyl palmitate, diethyl phthalate, dibutyl phthalate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate Stearate, polyoxyethylene hydrogenated castor oil, isopropyl myristate, octyldodecyl myristate, myristyl myristate, monooleyl polyoxyethylene sorbitan,
Ethylene glycol monostearate, propylene glycol monostearate, hexyl laurate, lanolin acetate, cetyl lactate, myristyl lactate. The following can be illustrated as a metal soap. Zinc undecylenate, aluminum stearate, calcium stearate, magnesium stearate, zinc stearate, zinc palmitate, magnesium myristate, zinc laurate.

The gum and water-soluble polymer compounds include
The following can be illustrated. Irish moss, gum arabic, propylene glycol alginate, alginic acid and its salts (ammonium alginate, potassium alginate, sodium alginate), algae colloid (cassius extract), albumin, ethyl cellulose, casein, carrageenan, karaya gum, carboxyalkyl chitin or chitosan, carboxyethyl cellulose. , Sodium carboxyethyl cellulose, carboxyvinyl polymer (Carbopol), carboxymethyl chitin or a salt thereof, carboxymethyl cellulose, carboxymethyl cellulose calcium, sodium carboxymethyl cellulose, carboxymethyl starch, agar, galactan, xanthan gum,
Chitin sulfate or its salt, chitosan or its salt, carob gum, quince seed gum, guar gum,
Guayak butter, glycol chitin, glycerogelatin, corn starch, collagen, chondroitin sulfate and its salts (sodium chondroitin sulfate, etc.), succinoglucan, zancoat, zanflo, carboxyvinyl polymer pre-neutralized with organic amines such as diisopropylamine and triethylamine. , Shellac, sodium cellulose sulfate, gelatin, tamarind gum, tara gum, dammar gum, dextrin, dermatan sulfate and its salt (sodium dermatan sulfate), starch, tragacanth gum, nitrocellulose, hyaluronic acid and its salt (sodium hyaluronate), hydroxy Alkyl chitin or chitosan, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl starch, hydro Cypropylmethyl cellulose, veegum, pullulan, heparan sulfate and its salts (sodium heparan sulfate, etc.), heparin, benzoin gum, pectin, polyacrylic acid salt (for example, sodium polyacrylate), polyalkylene oxide or its cross-linked polymer, polyethylene Imines, polyethylene oxides, polyethylene glycols, polyethylene glycol fatty acid esters, polyoxyethylene-polyoxypropylene block copolymers (for example, pluronics, etc.), polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene isostearyl ethers. , Polyoxyethylene oxypropylene alkyl ether, polyoxyethylene oxypropylene copolymer, polyoxyethylene cet Ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyvinyl alcohol, polyvinyl ether, polyvinylpyrrolidone, polyvinyl methacrylate, polyvinyl methyl ether, polypropylene oxide, macrogol, methyl cellulose, methyl hydroxypropyl cellulose, methyl hydroxypropyl starch , Laminaran, phosphorylated chitin or chitosan, roast bean gum, crystalline cellulose, low-substituted hydroxypropyl cellulose, low-molecular chitosan.

As the vitamin A group, the following can be exemplified. Carotene (provitamin A), dehydroretinol (vitamin A2), retinol (vitamin A1). The following can be illustrated as a vitamin B group. Inositols, choline, cyanocobalamin (vitamin B12), thiamine hydrochloride (vitamin B1 hydrochloride), thiamine sulfate (vitamin B1 sulfate), nicotinic acid amide, nicotinic acids, calcium pantothenate, pantothenic acids, biotins,
Pyridoxine (vitamin B6), riboflavin (vitamin B2), folic acid. The following can be illustrated as a vitamin C group. Ascorbic acid and its derivatives. The following can be illustrated as a vitamin D group. Ergocalciferol (vitamin D2), ergosterin (provitamin D2), cholecalciferol (vitamin D3), 7-dehydro-
Cholesterin (Provitamin D3). The following can be illustrated as a vitamin E group. Tocopherol and its derivatives. As vitamin K group,
The following can be illustrated. Phylloquinone (vitamin K1), Fuarnoquinone (vitamin K2), Menadiol (vitamin K4), Menadione (vitamin K)
3). Other vitamins and vitamin-containing substances include coenzyme Q and royal jelly.

Examples of amino acids include the following. Asparagine, aspartic acid, alanine, arginine, isoleucine, oxyproline,
Oxylysine, ornithine, glycine, glutamine, glutamic acid, cystine, cysteine, serine, tyrosine, tryptophan, threonine, valine, histidine, phenylalanine, proline, methionine, lysine, leucine, and their sulfates, phosphates, nitrates, citrates, etc. Acid salts, sodium salts, or amino acid derivatives such as pyrrolidonecarboxylic acid.

Examples of plants and herbal medicines are as follows. Ashitaba, Azuki (red azuki bean), Acerola, Asenyak (Asenyaku), Avocado, Amacha (sweet tea), Amateur Crane, Althea, Arnica, Aloe, Aloe Vera, Apricot (Apricot kernel), Ginkgo (Ginkgo leaf,
Ginkgo), Itohimehagi (distinct), nettle, sardine goby (red), fennel (incense), turmeric (light gold), usubasaishin (spicy), hemlock (summer hay), udo or shishudo (spoiler, independent activity), plum ( (Ume), Vladimir, Ural, Unshiu mandarin (Chen skin), Ebisugusa (Keimeiko), Enju (Sophora), Ougi (Yellow 耆), Oo Ren (Huang Lian), Psyllium (Cornaceae, Carp grass), Barley (malt), Panax ginseng (carrot), Hypericum (younger brother cut grass), Odorikosou, Dutch pepper, orange, oyster (persimmon), valerian (Yoshikusa), chamomile,
Kawamura Mugwort (Chinese linseed), Licorice (liquorice), Banjutsu (lichen), Raspberry, Kiwi fruit, Chikarasuuri (melon root), Kyoukyo (Kikyo), Chrysanthemum (Chrysanthemum), Kisage (Apricot), Yellowfin (Kashiwa) , Cucumber, wolfberry
Marlin, Marcus leaf, Camphor tree, Kudzu (Kudzu root), Gardenia (Yamasuko), Kumazasa, Clara (Ginseng), Mulberry (Mulberry bark, Mulberry leaf), Grapefruit fruit, Kaigai (Keikai), Gentiana, Gensho (Old) Birds), Koucha (black tea), Scutellaria baicalensis (Ouchon), Wheat, Goshuyu (Kurei), Gobaishi (quintile), burdock, saffron, saponsou, salvia, hawthorn (yamazako), Sanshi carrot (37 ginseng) , Sansho (Japanese pepper), Shiitake mushroom, Shikunshi (Kimiko), Shiso (Shiso leaf, Shiso),
Spirea, peony (peony), ginger (ginger), ginger (iris), birch, dio (ground yellow),
Janow mustache (Bakumon winter), Honeysuckle (gold and silver flowers, Shinobi winter),
Stevia, Ivy, Sambucus nigra, St. John's wort, Sengyu (river cucumber), senburi (our medicine), mallow, tachijakusa, tachibana (tachibana peel), arachis, soybean, red sea bream (orange peel), ginseng carrot ), Clove (chopsticks), ginseng (schisandra), camellia, centella asiatica, tsurudokudami (what-headed crow), capsicum (pepper), capsicum, capsicum (toki), capsicum, corn rat (madako), corn (nanbari fur) ), Eucommia vulgaris (Tochu, Tochu leaf), Tomato, Dokudami (10 medicines), Jujube (Oju), Narukoyuri, Nanten (Namitenmi), Nikkei (cinnamon skin), Elderflower (bone grafting), garlic (Large sun), Neubara (Fruit), Hakusen (white moss bark), Hashiridokoro (roth root), peppermint (light load), pigeon Formic (pearl barley, Coix), Anemarrhenae asphodeloides (knowledge mother), Hamamelis, rose, parsley,
Hyougi (dried dry), Hikiokoshi (prolonged life grass), Hinako no Kochi (cow knee), loquat leaf (Biwaki leaf), Areca (Columba coccinata), Fuyumusinatsukutake (winter caterpillar), grape or its leaf, loofah, safflower (safflower) ), Physalis (Torone), honoki (Koboku), hops, bokeh (wood melon), buttons (peony skin), bodaiju, maikai (mai agate flower), matsuhodo (bottle lily), malva morning glory or morning glory (ken beef) , Horse chestnut, ganoderma lucidum, ganoderma lucidum, citrus fruit (clover), mishimasiko (shibaiko), mukuroji, murasaki (purple root), swordfish (beneficial herb), melissa, merlot, moco wormwood, peach (peach root, peach leaf), Bean sprouts, cornflowers, cherry trees (cherry bark), bayberry (Yangmei bark), bayberry, Yukinoshita (tiger ear grass), mugwort ( Lee leaves), Swingle, lavender, green tea (green tea), apple fruit, lemon fruit, forsythia (Forsythia), Rengesou, burnet (Chinire), pine needles, rice, rice bran. The above plants and herbal medicines can be used in the composition of the present invention as they are or in the form of extracts. The extract is water, an organic solvent (1,3-butylene glycol, acetone, ether, ethanol, propylene glycol, methyl ethyl ketone, ethyl acetate, etc.)
It is prepared by extraction with one or two or more mixed solvents.

Examples of animal-derived substances include the following. As the extraction method, a method similar to that for plants and crude drugs can be used. Elastin,
Elastin hydrolyzate, collagen hydrolyzate, silk protein, silk protein hydrolyzate, bovine / human placenta extract, bovine blood cell protein hydrolyzate, livestock organ or organ extract or its hydrolyzate (chicken gooseberry, pig)・ Stomach of the cow, duodenum, or intestine),
Water-soluble elastin derivative, water-soluble collagen, water-soluble collagen derivative. Examples of those derived from a microbial culture include the following. Selenium-containing yeast extract, euglena extract, yeast extract, lactic acid fermentation product of skim milk powder, rice fermentation extract.

Examples of the fragrance include the following. Natural animal flavors such as Ambergris, Castorium, Civet, Musk. Anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, cumin essential oil, guaiac wood essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla Essential oil, cedarwood essential oil,
Citronella essential oil, cinnamon essential oil, jasmine essential oil, ginger grass essential oil, spearmint essential oil, tuberose essential oil, true balsam essential oil, butchery essential oil, rose essential oil, basil essential oil, palmarosa essential oil, hiba essential oil, petitgrain essential oil, bay essential oil, vetiver essential oil, bergamot essential oil,
Peruvian balsam essential oil, boad rose essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, black character essential oil, cedar essential oil, western mint essential oil, large scented essential oil, taiji essential oil, Vegetable-based fragrances such as winter green essential oil, sandalwood essential oil, scented essential oil, Japanese peppermint essential oil, cypress essential oil, orange essential oil, and other synthetic fragrances.

Examples of carboxylic acids include the following. Succinic acid, citric acid, glycolic acid, malic acid, tartaric acid, lactic acid. As a pH adjuster,
The following can be illustrated. L-aspartic acid, L-glutamic acid, arginine, citric acid, diisopropanolamine, phosphate buffer, hydrochloric acid, tartaric acid, acetic acid, potassium hydroxide, sodium hydroxide, lactic acid.
The following can be illustrated as a buffering agent. Aminoacetic acid, citric acid, sodium citrate, Hind-Goyan buffer [consisting of sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride], Britton-Robinson (Brit)
ton-Robinson) buffer [consisting of phosphoric acid, acetic acid, boric acid, and sodium hydroxide], borax, boric acid,
Phosphoric acid, alkali metal salts of phosphoric acid (dipotassium hydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate,
Sodium dihydrogen phosphate), phosphate buffer, acetic acid, sodium acetate, sodium acetate buffer, sodium carbonate, sodium hydrogen carbonate.

Examples of the anionic surfactant include the following. 1,2-Bis [(2-ethylhexyl) oxycarbonyl] ethanesulfonic acid sodium salt (a kind of dialkylsulfosuccinic acid ester salt); 2-[(C2n alkyl) (OCH ₂ CH ₂ ) m] acetic acid sodium salt or , Potassium salt (n of carbon number
Is an integer from 6 to 9. m is an integer); (C2n alkyl)
Benzenesulfonic acid sodium salt (the carbon number n is 6
To an integer of 9); [4-ethyl-1- (2-methylpropyl) octyl] sulfate sodium salt; N-
[(Carbon number (2n-1) alkyl) carbonyl] -N-methyl-β-alanine sodium salt (n of carbon number is an integer of 6 to 9); N-[(carbon number (2n-1) alkyl) Carbonyl]
-N-methylglycine sodium salt (n of carbon number is
N-[(C (2n-1) alkyl) carbonyl] -N-methyltaurine sodium salt, potassium salt or triethanolamine salt (n of carbon number)
Is an integer of 6 to 9); N-[(carbon number (2n-1) alkyl)
Carbonyl] glutamic acid disodium salt (carbon number
n is an integer of 6 to 9); alkyl phosphate ester salt [(C2nalkyl) O] mP (O) (OM) t, (wherein n
Is an integer from 6 to 9, m is an integer from 1 to 3, t is 0 to 2
Integer. M is potassium, sodium, etc.); alpha-olefin sulfonate sodium salt, alkene (C ₈ ~C ₃₀₎ monosulfonic acid sodium salt (R-CH = CH- (CH 2) n-SO 3 Na),
Hydroxyalkane (C ₈ ~C ₂₄₎ sulfonic acid sodium salt _{(R-CH 2 -CH (OH} ) - (CH 2) m-SO 3 Na) ( wherein, m, n are,
Edetate; lauryl sulfate sodium salt; carbon number (2n-1) alkanecarboxylic acid sodium salt or potassium salt (n of carbon number is an integer of 6 to 9);

Examples of the cationic surfactant include the following. 1- (C2n alkyl) -1- (carbon m alkyl) -2- (carbon t alkyl) -imidazolinium chloride or bromide (carbon number, n is an integer of 6 to 12. m is , An integer from 1 to 5. t
Is an integer of 1 to 4); 1- (C2n alkyl) -2-
(Ct alkyl) -imidazolinium chloride or bromide (carbon number, n is an integer of 6 to 12; t is an integer of 1 to 4); benzalkonium chloride ([PhCH ₂ N ( CH
^{_{3) 2 (R)] +}} · X -) [ wherein, R has a carbon number of 2n alkyl (n
Is an integer of 6 to 12), X is chlorine or bromine]; benzethonium chloride [[2- [2- [4- (1,1,3,3-tetramethylbutyl) phenyloxy] ethyloxy] ethyl]
(Phenylmethyl)] (dimethyl) ammonium chloride; Aliphatic quaternary ammonium salt ([R ¹ (R ² ) N (CH ₃ ) ₂ ] ^+.
X ^-) [In the formula, R ¹ is the number 2n alkyl (n carbon, of 6-9 integer). R ₂ is alkyl having 2n carbon atoms (n is an integer of 6 to 9) or methyl. X is chlorine or bromine];
Aliphatic amine salt (RN (R ¹ ) R ² organic acid salt or inorganic acid salt) [In the formula, R 2 is an alkyl having 2n carbon atoms (n is an integer of 6 to 9). R ¹ and R ² are each hydrogen or methyl]; carbon number 2n alkylpyridinium chloride or bromide (n of carbon number is an integer of 6 to 9).

Examples of the amphoteric surfactant include the following. 1-carboxymethyl-1-
Hydroxyethyl-2- (carbon number (2n-1) alkyl) imidazolinium hydroxide inner salt (n of carbon number is 6
~ 9 (integer of 9); 2-[(C2n alkyl) amino] acetic acid (n of carbon is an integer of 6 to 9); 3-[(Cn of 2n
Alkyl) amino] propionic acid (n of carbon number is 6 to
(Integer of 9); (2n alkyl of carbon) (carboxymethyl) dimethylammonium hydroxide inner salt (n of carbon is an integer of 6 to 9); (2n alkyl of carbon) [2-
(Carboxy) ethyl] dimethylammonium hydroxide inner salt (n of carbon number is an integer of 6 to 9); N-
[(C (2n-1) alkyl) carbonyl] -N- (2-
Hydroxyethyl) -N'-carboxymethylethylenediamine (n in carbon number is an integer of 6 to 9); N-[(carbon number (2n-1) alkyl) carbonyl] -N'-carboxymethyl-N '-( 2-hydroxyethyl) ethylenediamine (n in carbon number is an integer of 6 to 9); laurylsulfobetaine; lecithin.

Examples of the nonionic surfactant include the following. Cetyl isooctanoate,
Ethyl oleate, ethyl caprylate, glycerin monostearate, glycerin fatty acid ester, sucrose fatty acid ester, silicone oil, silicone derivatives such as silicone resin, diglyceryl distearate, sorbitan sesquioleate, sorbitan monostearate, sorbitan monostearate, Sorbitan fatty acid ester, polyethylene glycol fatty acid ester, polyol-modified silicone, polyoxyethylene (50) hydrogenated castor oil, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxy Ethyleneoxypropylene copolymer, polyoxyethylene glycerin fatty acid ester, polyoxyethylene cetyl ether, poly Xyethylene sterol ether, polyoxyethylene sorbitan monooleate (for example, polysorbate 80), polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene castor oil derivative, polyoxy Ethylene hydrogenated castor oil, polyoxyethylene higher alcohol ether, polyoxyethylene fatty acid ester, polyglycerin alkyl phenyl ether, polyglycerin fatty acid ester, isopropyl myristate, monooleyl polyoxyethylene sorbitan, glyceryl monooleate, propylene glycol monooleate , Sorbitan monocaprate, glyceryl monostearate, decaglyceryl monolaurate Ester and the like. The following can be illustrated as a nitrogen-containing nonionic surfactant. N- (2-hydroxyethyl)-(carbon number (2n-1) alkane) carboxylic acid amide (n of carbon number is an integer of 6 to 9); N, N-bis (2-
Hydroxyethyl)-(carbon number (2n-1) alkane) carboxylic acid amide (n of carbon number is an integer of 6 to 9); N, N-
Bis (polyoxyethyl)-(carbon number (2n-1) alkane)
Carboxylic amide (n of carbon number is an integer of 6 to 9);
(C2n alkyl) dimethylamine oxide (n of carbon is an integer of 6 to 9).

Other surfactants include the following. Natural surfactants, protein hydrolyzate derivatives, polymer surfactants, surfactants containing titanium / silicon, fluorocarbon surfactants. The following can be illustrated as an inorganic pigment. Bismuth oxychloride, carbon black, kaolin, calamine, clay, gunjou, magnesium silicate, talc, white titanium, red iron oxide, bentonite, mica, lithopone, zinc white, mica titanium, yellow iron oxide, black iron oxide, chromium oxide, oxidation Zirconium, titanium oxide, magnesium oxide, zinc oxide, chromium hydroxide, calcium carbonate, magnesium carbonate, silicic acid anhydride, barium sulfate. The following can be illustrated as an ultraviolet absorber. 4-t-
Butyl-4'-methoxy-dibenzoylmethane, methyl anthranilate, urocanic acid, ethyl urocanate,
Umbelliferone, esculin; cinnamic acids [eg,
4-Methylcinnamate 4-methoxy, Isopropyl 4-methoxycinnamate, Ethyl 4-methoxycinnamate, Octyl 4-methoxycinnamate, Butyl 4-methoxycinnamate, 2,4-Diisopropylcinnamate Methyl,
2,4-Diisopropylethyl cinnamate]; salicylic acids [eg pt-butylphenyl salicylate, p-octylphenyl salicylate, 2-ethylhexyl salicylate, titanium salicylate, phenyl salicylate, homomenthyl salicylate, myristyl salicylate, propylene glycol salicylate. ]; Benzotriazoles [eg, 2- [2-hydroxy-3,5-di (t-butyl) phenyl] benzotriazole, 2- (2-hydroxy-3-t-butyl-5-methylphenyl) benzotriazole , 2- (2-hydroxy-5-methylphenyl) benzotriazole]; benzophenones [eg, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone] , 2, 2 ' -Dihydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2-hydroxy-4-octyloxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2
-Hydroxy-4-methoxybenzophenone sulfonic acid, oxybenzone sulfonic acid, oxybenzone sulfonic acid (trihydrate), sodium dihydroxydimethoxybenzophenone sulfonate]; paraaminobenzoic acids (eg, paraaminobenzoic acid, ethyl paraaminobenzoate, glycerin paraaminobenzoate) , Amyl paradimethylaminobenzoate, ethyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate). The following can be illustrated as an antioxidant. Ascorbic acid and its salts, gossypol, stearic acid ester, sesamol, sesamolin, tocopherol and its ester derivatives, nordihydroguaselethenoic acid, parahydroxyanisole, butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), sodium sulfite, Propyl gallate.

Examples of anti-inflammatory agents include the following. dl-α-tocopherol and its derivative, d or dl-camphor, azulene, acetylsalicylic acid, ictamol, indomethacin, chamazulen, guaiazulene, glycyrrhizinic acid and its salt (dipotassium glycyrrhizinate), glycyrrhetinic acid and its salt, glycyrrhetinic acid derivative, salicylic acid , Sodium salicylate, methyl salicylate, hydrocortisone,
Vitamin B2 and B6, chlorpheniramine maleate, lysozyme chloride, diphenhydramine hydrochloride, licorice extract. Examples of the sterilizing / disinfecting agents are as follows. Acrinol, sulfur, isopropylmethylphenol, orthomethoxycinnamaldehyde, cresol, chlorhexidine gluconate, sulfamine, cetylpyridinium salt (cetylpyridinium chloride), sorbic acid, paraoxybenzoic acid esters (ethyl paraoxybenzoate, propyl paraoxybenzoate) , Methyl paraoxybenzoate), parachlorometaxylenol, hinokitiol, hibitene, benzalkonium salt (benzalkonium chloride), benzethonium salt (benzethonium chloride), lactoferrin or its hydrolyzate, decalinium chloride, chloride Methyl rosaniline.

The following astringents can be exemplified. Zinc p-phenolsulfonate, allantoin, calamine, citric acid, succinic acid, tannic acid, birch extract, aluminum polypyrrolidonecarboxylate, resorcin, aluminum chloride, zinc chloride, ferric chloride, zinc oxide, tartaric acid, lactic acid, Aluminum potassium sulfate, zinc sulfate. The following can be illustrated as an agent for hair. Cantalis tincture,
Ginger deer tincture, zinc pyrithione, thiantol, thioglycolic acid, capsicum tincture, biphenamine, quinine hydrochloride, strong ammonia water, alkylisoquinolinium bromide solution, potassium bromate, sodium bromate,
Selenium disulfide.

The food, drug, quasi drug of the present invention, and
As the composition used in cosmetics, awamori which is the active ingredient according to the present invention may be used as it is, or a water diluted product or a molecular sieve obtained by removing a part of water or ethanol. Further, it can be used by processing or formulation into a composition containing a substance for exerting the effect more reliably additively or synergistically without impairing the effect of the active ingredient according to the present invention. The amount of awamori contained in such a processed or formulated composition is 0.1 to 99.9 in terms of ethanol content of 45 degrees.
%, Preferably 0.5 to 80%. In addition to awamori, a processed or formulated composition can be prepared by selecting a substance suitable for the desired composition from the above-exemplified substances and, if necessary, adding other substances as appropriate.
For example, when preparing the composition according to the present invention, linolenic acid (α-linolenic acid, which is recognized to have antiallergic efficacy,
(γ-linolenic acid), perilla oil, evening primrose oil, perilla essential oil and the like are preferably used in combination. Further, it is also preferable to use the non-reducing sugar trehalose in combination, which is less likely to chemically change other components during storage and has excellent storage stability of the composition.

The method of incorporating awamori into the processed or formulated composition may be such that it is included in the steps until the composition is completed. For example, mixing, dissolving, melting, dipping, penetrating, spraying, coating Known methods such as coating, spraying, pouring, crystallization, and solidification are appropriately selected. In the composition according to the present invention, the daily intake of food and pharmaceutical oral preparation is
As an adult (with a body weight of 60 kg), it is diluted with water and converted into an awamori prepared with an ethanol content of 35 degrees, which is 0.5 to 50.
cc, preferably 5 to 40 cc. This amount may be ingested once or divided into two or more doses regardless of the form of the composition. The content of awamori in foods and oral pharmaceutical preparations can be appropriately selected within the above-mentioned intake range. If you take food or oral medicines before the onset of allergic symptoms, you can get a preventive effect,
If taken after the onset, the therapeutic effect can be obtained. The timing and period of ingestion are, for example, 1 week to 3 months before the onset of the onset, preferably when the onset of onset such as Japanese cedar pollinosis overlaps with the time when the Japanese cedar pollen is scattered. A prophylactic effect can be obtained by ingesting from 3 weeks to 3 months ago. If the ingestion of the present invention is continued after the preventive ingestion and after the start of the scattering of the cedar pollen, the onset is not observed or the symptoms are remarkably reduced due to the therapeutic effect combined with the preventive effect. This also applies to other allergens. The effect obtained in the above-mentioned cedar pollinosis is the absence or alleviation of allergic conjunctivitis such as itchy eyes, pain and hyperemia, and nasal allergic symptoms such as sneezing and stuffy nose and runny nose. In the composition according to the present invention, the amount of parenteral drug, quasi drug, and cosmetic used and the timing of use vary depending on the target organ, preventive purpose or therapeutic purpose, etc.
At most, it is about an oral intake amount, and for example, when the ointment is applied to the nose (lower turbinate) or is used locally such as an olfactory agent, the use amount is small. Further, the composition according to the present invention can be used not only for humans but also for warm-blooded mammals such as rat, rabbit, sheep, pig, cow, cat, dog and monkey. Next, the present invention will be described more specifically by way of examples, but the present invention is not limited to these examples.

[0038]

[Examples] In the following examples, Awamori old liquor (stored for 5 years. Ethanol content 3
(5 times) "Choufu (registered trademark)" was used. Test Example 1 For 20 years, at the time when the cedar pollen was scattered, almost 1 year after the cedar pollen started to be dispersed to a subject (adult male) who exhibited symptoms of cedar pollinosis such as sneezing, runny nose, and eye itch.
From a month ago, 15 ml of awamori was administered daily in the morning and evening.
The drug was taken until the warning about the scattering of cedar pollen was not given, but there were no particular restrictions on diet and other lifestyles. One month after the administration, the preventive effect and the therapeutic effect were evaluated based on the subject's daily subjective symptoms. Symptoms were significantly less than usual at any time during the period when the warning for the scattering of Japanese cedar pollen was reported. In addition, after the start of administration, which is at the peak of the scattering of cedar pollen,
The subjective symptoms on the 60th day were markedly reduced by taking the same day.

Test Example 2 At the time when cedar pollen was scattered for 10 years, a warning (sculpture of cedar pollen) was given to a subject (adult man) exhibiting symptoms of cedar pollinosis such as sneezing, runny nose, and eye itch. It was reported that 3 days after the subjective symptoms were recognized, 15 ml of awamori
I took it every morning and evening. The drug was taken until the warning about the scattering of cedar pollen was not given, but there were no particular restrictions on diet and other lifestyles. From the day of administration, the therapeutic effect was judged based on the daily subjective symptoms of the test subjects. From 1 to 2 hours after taking the drug, a clear symptom-relieving effect is 10
I was aware that it would continue for about an hour. This mitigation effect was also observed during the peak period of cedar pollen scattering.

Preparation Example 1 Preparation of Fruit Jelly 100 g of granulated sugar (a kind of purified sucrose) and 300 g of water were put in a pan and heated to form a solution. Then, 12 g of powdered gelatin moistened with water was added to the solution whose heating was stopped to dissolve it. The mixture is cooled with ice water,
When the temperature of the mixture reached room temperature, 50 g of awamori and 1/2 of lemon juice were added. When the water temperature is reached by further cooling, the longest side is chopped into 1.5 cm pieces of strawberries, sweet cherry and melon, each weighing 40 g, for a total of 120
g was added and mixed until thick. Then
The mixture was divided into approximately 4 equal parts, placed in a container, and cooled in a refrigerator until they solidified to prepare fruit jelly containing awamori.

Preparation Example 2 Preparation of Lemon Sorbet 100 g of fruit juice for 4 lemons, 100 g of granulated sugar (a kind of refined sucrose) and 200 g of water at 40 ° C. were put in a bowl and mixed well, and when the granulated sugar was dissolved, 30 g of awamori Was added and mixed, wrapped and wrapped in a freezer.
When the whole was about to solidify, whisk well with a whisk, rewrap and put in the freezer. This operation was repeated five times. Then, divide the mixture into four equal parts, put them in a container,
A lemon sherbet containing awamori was prepared by freezing in a freezer.

Preparation Example 3 Preparation of Sauce of Roasted Meat Soy sauce, 2 tablespoons of awamori, 1 tablespoon of sesame oil, sugar, apple juice, 1 tablespoon of ground sesame seeds, 1 piece of garlic, 1 teaspoon of starch starch, 1 teaspoon of evening primrose oil, a little pepper , A small amount of powdered capsicum were mixed well to prepare a sauce of roasted meat containing awamori.

Preparation Example 4 Preparation of Nanban vinegar 1 cup of soup stock, 0.5 cup of soy sauce, 0.3 cup of vinegar,
2 tablespoons of sugar and 1 tablespoon of mirin were boiled and added with 0.25 cups of awamori and 1 capsicum to prepare nanban vinegar containing awamori.

Preparation Example 5 Preparation of Black Tea Beverage (Composition) (g) Awamori 7.0 Granulated Sugar 8.0 Flavor 0.1 Food Salt 0.05 Black Tea Extract Water A) 84.8 The above 5 components are homogeneous To prepare a black tea beverage containing awamori. A) Teabag black tea was extracted with 100 cc of hot water and ice pieces were added to make 200 cc.

Preparation Example 6 Preparation of juice (composition) (g) Awamori 3.0 Frozen concentrated Unshu mandarin orange juice 5.0 Fructose glucose liquid sugar 11.0 Quenoic acid 0.2 L-Ascorbic acid 0.02 Fragrance Food 0.2 color 0.1 Water 80.48 The above 9 components were uniformly mixed to prepare a juice containing awamori.

Preparation Example 7 Preparation of Injectable Solution 3 g of awamori was added to purified water to make the total amount 200 g, and bacteria were sterilized using a Millipore filter GS type to prepare an injectable solution.

Preparation Example 8 Preparation of plaster drug To 200 g of trehalose and 300 g of maltose, 50 g of Awamori was added and mixed, and 200% of 10% pullulan aqueous solution was added.
g was added and mixed to prepare a plaster drug exhibiting a proper extension and adhesiveness.

Preparation Example 9 Preparation of Ointment 70 g of propylene glycol and 14 g of polyethylene glycol were dissolved by heating at 60 ° C., and awamori 25 was added while stirring.
g and benzyl alcohol 1 g were gradually added, and the mixture was stirred to 30 ° C. and then naturally cooled to prepare an ointment.

Preparation Example 10 Preparation of Ointment An ointment was prepared by uniformly mixing 37 g of awamori, 20 g of squalane, 20 g of glycerin, 5 g of cetyl alcohol, 3 g of magnesium stearate and 5 g of propylene glycol.

Preparation Example 11 Preparation of lotion 5 g of glycerin and propylene glycol alginate
To 2 g of the mixture, 1 g of polyoxyethylene cetyl ether (20EO) was dissolved in 25 g of awamori while stirring, 68.8 g of purified water was added, and the resulting mixture was added little by little to prepare a lotion.

Preparation Example 12 Preparation of lotion To a mixture of 5 g of glycerin and 0.5 g of polyoxyethylene castor oil derivative, a mixture of 20 g of awamori, 3 g of sorbitol, 0.1 g of allantoin and 71.4 g of purified water was stirred into a small amount. A lotion was prepared by adding each amount.

Preparation Example 13 Preparation of Emulsion 5 g of dipropylene glycol was added to 48.4 g of purified water, heated and stirred, and the temperature was maintained at 60 ° C., to which 15 g of quince seed gum 5% aqueous solution, 0.3 g of fragrance, Stearic acid 1.3 g, cetanol 0.7 g, beeswax 2.
0 g, 1.2 g of polyoxyethylene (11) mol oleate, 0.8 g of glycerin monostearate and 0.3 g of methyl paraben were added and stirred, and then uniformly emulsified with a homogenizer. While cooling the obtained emulsion, 25 g of Awamori was gradually added with stirring and cooled to room temperature to prepare an emulsion.

Preparation Example 14 Preparation of Hair Tonic A hair tonic was prepared by uniformly mixing 70 g of awamori, 27 g of water, 2 g of polyoxyethylene (40) hydrogenated castor oil and 1 g of ethyl oleate.

Preparation Example 15 Preparation of Hair Tonic A mixture of 40 g of Awamori and 57.3 g of ethanol was added to 0.3 g of Assemblage extract, 0.025 g of hinokitiol, 0.2 g of Vitamin E acetate and 0.0 of L-menthol.
6, D-pantothenyl ethyl ether 0.35 g, β-
Glycyrrhetinic acid 0.1 g, sodium lauryl sulfate 0.1 g, nicotinic acid amide 0.1 g, hydroxypropyl cellulose 0.6 g, polyvinylpyrrolidone 0.2
and 0.7 g of α, α-trehalose were added and mixed uniformly to prepare a hair tonic.

Preparation Example 16 Preparation of Hair Essence Agent A mixture of 20 g of awamori and 72.5 g of water was added to 2.0 g of ginseng extract, 0.01 g of peppermint oil, 0.25 g of D-pantothenyl alcohol, and 0.25 g of dipotassium glycyrrhizinate.
1 g, methyl paraoxybenzoate 0.1 g, propyl paraoxybenzoate 0.025 g, polyvinyl alcohol 1.25 g, carboxymethylcellulose sodium salt 0.75 g, polyvinylpyrrolidone 0.05 g, and
3.0 g of α, α-trehalose was added and uniformly mixed to prepare a hair essence agent.

Preparation Example 17 Preparation of shampoo 25 g of awamori, 21 g of purified water, lauryl polyoxyethylene (3 mol) sulfuric acid ester triethanolamine salt (4
0% aqueous solution) 30 g, lauryl polyoxyethylene (3
Mol) sulfate sodium salt (40% aqueous solution) 20
g and 4 g of lauroyl diethanolamide were uniformly mixed to prepare a shampoo.

Preparation Example 18 Preparation of body soap 15 g of awamori, 60 g of purified water, 15 potassium laurate
g, potassium myristate 5 g, propylene glycol 5 g, perilla essential oil 0.05 g, and hinokitiol 0.0
A body soap was prepared by uniformly mixing 5 g.

Preparation Example 19 Preparation of Bath Salt 2 g of sodium sulfate, 2 g of sodium hydrogen carbonate, 2 g of sodium chloride and 2 g of α, α-trehalose were dissolved in 62 g of purified water. Then, 30 g of awamori and 0.05 g of basil essential oil were added to this solution to prepare a bath agent.

[0059]

EFFECTS OF THE INVENTION The present inventors have found that awamori, whose properties are well known as alcoholic beverages, can be used as an antiallergic active ingredient. Therefore, the food, drug, quasi drug and cosmetic containing the awamori according to the present invention can be used for the prevention and treatment of allergic diseases.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code Agency reference number FI Technical display location A61K 7/48 A61K 7/48

Claims (4)

[Claims] 1. A food containing awamori as an antiallergic active ingredient. 2. A pharmaceutical product containing awamori as an antiallergic active ingredient. 3. A quasi drug containing awamori as an antiallergic active ingredient. 4. A cosmetic containing awamori as an antiallergic active ingredient.