WO2007031620B1 - Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation - Google Patents
Mousses dermatologiques a base de metronidazole et emulsions pour leur preparationInfo
- Publication number
- WO2007031620B1 WO2007031620B1 PCT/FR2006/002037 FR2006002037W WO2007031620B1 WO 2007031620 B1 WO2007031620 B1 WO 2007031620B1 FR 2006002037 W FR2006002037 W FR 2006002037W WO 2007031620 B1 WO2007031620 B1 WO 2007031620B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mass
- metronidazole
- emulsions
- preparation
- production
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des émulsions comprenant, en pourcentage en masse par rapport à la masse totale de Ia composition : (a) 70% a 81 % d'eau ; (b) 0,1% a 5% d'un agent gélifiant de la phase aqueuse de l'émulsion ; (c) 0,75% a 2% de métronidazole ; (d) 4% a 10% d'huile minérale ; (e) 0,5% a 10% d'un agent tensioactif ; (f) 0,5% a 5% d'un acide gras ; (g) 0,1% a 5% d'un agent conservateur ; et (h) 0 a 5% d'un promoteur d'absorption du métronidazole. L'invention concerne également des mousses à base de métronidazole obtenues à partir de ces émulsions, ainsi que leur utilisation dermatologique.
Claims
1. Composition à base de métronidazole choisie parmi les compositions suivantes :
2. Procédé de préparation d'une composition selon la revendication 1 , comprenant les étapes successives suivantes : - on prépare un milieu aqueux A comprenant l'eau (a), l'agent gélifiant (b), le métronidazole (c), le tensioactif (e), et, le cas échéant, le promoteur d'absorption (h) ;
- on prépare un milieu hydrophobe H comprenant l'huile minérale (d), et tout autre constituant de la phase grasse ; - on mélange les milieux A et H ainsi obtenus, et on émulsifie le système ainsi formé ;
- le conservateur (g) est ajouté en fin d'émulsification ;
- mélange de l'émulsion obtenue avec un gaz.
3. Utilisation d'une composition selon la revendication 1 , pour la préparation d'une mousse dermatologique destinée au traitement prophylactique ou thérapeutique d'une affection cutanée, par voie topique. 44
4. Utilisation selon la revendication 3, pour la préparation d'une mousse dermatologique destinée au traitement de la rosacée.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06808065A EP1928416A2 (fr) | 2005-09-13 | 2006-09-05 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
US12/076,115 US20090041678A1 (en) | 2005-09-13 | 2008-03-13 | Metronidazole-based dermatological foams and emulsions for the preparation thereof |
US13/154,476 US20110237637A1 (en) | 2005-09-13 | 2011-06-07 | Metronidazole-based dermatological foam and emulsions for the production thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0509342A FR2890560B1 (fr) | 2005-09-13 | 2005-09-13 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
FR0509342 | 2005-09-13 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/076,115 Continuation US20090041678A1 (en) | 2005-09-13 | 2008-03-13 | Metronidazole-based dermatological foams and emulsions for the preparation thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2007031620A2 WO2007031620A2 (fr) | 2007-03-22 |
WO2007031620A3 WO2007031620A3 (fr) | 2007-05-03 |
WO2007031620B1 true WO2007031620B1 (fr) | 2007-06-21 |
Family
ID=36601229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2006/002037 WO2007031620A2 (fr) | 2005-09-13 | 2006-09-05 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
Country Status (4)
Country | Link |
---|---|
US (2) | US20090041678A1 (fr) |
EP (1) | EP1928416A2 (fr) |
FR (1) | FR2890560B1 (fr) |
WO (1) | WO2007031620A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107823123A (zh) | 2011-06-28 | 2018-03-23 | 化学研究有限公司 | 高剂量粘膜粘附甲硝唑水基凝胶制剂及其治疗细菌性阴道病的用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837378A (en) * | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
US5536743A (en) * | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
US5300491A (en) * | 1991-10-31 | 1994-04-05 | Apothekernes Laboratorium A.S. | Treatment of protozoal infection |
US6468989B1 (en) * | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
CA2502986C (fr) * | 2002-10-25 | 2011-08-23 | Foamix Ltd. | Mousse cosmetique et pharmaceutique |
JP2007503428A (ja) * | 2003-08-25 | 2007-02-22 | フォーミックス エルティーディー. | 浸透性医薬発泡剤 |
US20050255048A1 (en) * | 2004-05-15 | 2005-11-17 | Collegium Pharmaceutical, Inc. | Sprayable formulations for the treatment of acute inflammatory skin conditions |
US20060024243A1 (en) * | 2004-08-02 | 2006-02-02 | Agis Industries (1983) Ltd. | Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same |
-
2005
- 2005-09-13 FR FR0509342A patent/FR2890560B1/fr not_active Expired - Fee Related
-
2006
- 2006-09-05 WO PCT/FR2006/002037 patent/WO2007031620A2/fr active Application Filing
- 2006-09-05 EP EP06808065A patent/EP1928416A2/fr not_active Withdrawn
-
2008
- 2008-03-13 US US12/076,115 patent/US20090041678A1/en not_active Abandoned
-
2011
- 2011-06-07 US US13/154,476 patent/US20110237637A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090041678A1 (en) | 2009-02-12 |
FR2890560A1 (fr) | 2007-03-16 |
EP1928416A2 (fr) | 2008-06-11 |
WO2007031620A2 (fr) | 2007-03-22 |
FR2890560B1 (fr) | 2011-06-24 |
US20110237637A1 (en) | 2011-09-29 |
WO2007031620A3 (fr) | 2007-05-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007031621B1 (fr) | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation | |
JP2000351726A (ja) | エアゾール製剤 | |
ZA200510388B (en) | Foamable pharmaceutical compositions and methods for treating a disorder | |
WO2004039749A1 (fr) | Procede de fabrication d'une plaque de platre legere | |
JP2018510181A (ja) | ラメラ液晶構造を持つ多重エマルジョン剤形の化粧料組成物 | |
WO2007117720A3 (fr) | Agents hydrophobes formant une dispersion stable dans des emulsions huile dans eau | |
WO2002078650A1 (fr) | Preparation d'emulsion cosmetique et agent pour usage externe | |
JP4979379B2 (ja) | 二液型発泡体、その安定な分散体、および対応する製造プロセス | |
WO2007031620B1 (fr) | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation | |
JPH01156906A (ja) | スキンコンデイショニングエアゾールフオーム組成物 | |
JP2010018490A (ja) | セメント構造物用被覆養生剤 | |
US9408786B2 (en) | Method for the treatment of skin | |
CA2507006A1 (fr) | Procede de fabrication de produits de soin personnel au moyen d'une phase d'eau concentree | |
CA2798099A1 (fr) | Procede de fabrication d'une composition de rasage en aerosol comprenant un agent hydrophobe formant au moins une microgouttelette | |
ATE395903T1 (de) | Schäumende o/w-emulsion und ihre verwendung in der kosmetik | |
PL1622986T3 (pl) | Alkidowe emulsje żywiczne dla powłok lakierniczych | |
WO2003082220A3 (fr) | Procede pour la production d'emulsions | |
PT94911A (pt) | Processo para a preparacao de formulacoes famaceuticamente compreendendo pelo menos propileno glicol decilmetilsulfoxido e penciclovir | |
JP5154780B2 (ja) | 一酸化窒素産生促進剤及びその利用 | |
US2086479A (en) | Stable emulsion and method of producing the same | |
CN107137352B (zh) | 一种新型泡沫剂 | |
KR20180098300A (ko) | 할로베타솔 발포체 조성물 및 이의 사용 방법 | |
WO2011108538A1 (fr) | Tensio-actif pour stabiliser une microémulsion eau/dioxyde de carbone supercritique | |
JP3072566B2 (ja) | 皮膚外用剤 | |
KR101461666B1 (ko) | 발레르산 아세트산 프레드니졸론을 함유하는 o/w 형 유화제제 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2006808065 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWP | Wipo information: published in national office |
Ref document number: 2006808065 Country of ref document: EP |