WO2007031620A3 - Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation - Google Patents

Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation Download PDF

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Publication number
WO2007031620A3
WO2007031620A3 PCT/FR2006/002037 FR2006002037W WO2007031620A3 WO 2007031620 A3 WO2007031620 A3 WO 2007031620A3 FR 2006002037 W FR2006002037 W FR 2006002037W WO 2007031620 A3 WO2007031620 A3 WO 2007031620A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass
metronidazole
emulsions
production
agent
Prior art date
Application number
PCT/FR2006/002037
Other languages
English (en)
Other versions
WO2007031620A2 (fr
WO2007031620B1 (fr
Inventor
Dov Tamarkin
Doron Friedman
Original Assignee
Galderma Sa
Dov Tamarkin
Doron Friedman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa, Dov Tamarkin, Doron Friedman filed Critical Galderma Sa
Priority to EP06808065A priority Critical patent/EP1928416A2/fr
Publication of WO2007031620A2 publication Critical patent/WO2007031620A2/fr
Publication of WO2007031620A3 publication Critical patent/WO2007031620A3/fr
Publication of WO2007031620B1 publication Critical patent/WO2007031620B1/fr
Priority to US12/076,115 priority patent/US20090041678A1/en
Priority to US13/154,476 priority patent/US20110237637A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Abstract

La présente invention concerne des émulsions comprenant, en pourcentage en masse par rapport à la masse totale de Ia composition : (a) 70% a 81 % d'eau ; (b) 0,1% a 5% d'un agent gélifiant de la phase aqueuse de l'émulsion ; (c) 0,75% a 2% de métronidazole ; (d) 4% a 10% d'huile minérale ; (e) 0,5% a 10% d'un agent tensioactif ; (f) 0,5% a 5% d'un acide gras ; (g) 0,1% a 5% d'un agent conservateur ; et (h) 0 a 5% d'un promoteur d'absorption du métronidazole. L'invention concerne également des mousses à base de métronidazole obtenues à partir de ces émulsions, ainsi que leur utilisation dermatologique.
PCT/FR2006/002037 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation WO2007031620A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06808065A EP1928416A2 (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation
US12/076,115 US20090041678A1 (en) 2005-09-13 2008-03-13 Metronidazole-based dermatological foams and emulsions for the preparation thereof
US13/154,476 US20110237637A1 (en) 2005-09-13 2011-06-07 Metronidazole-based dermatological foam and emulsions for the production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0509342 2005-09-13
FR0509342A FR2890560B1 (fr) 2005-09-13 2005-09-13 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/076,115 Continuation US20090041678A1 (en) 2005-09-13 2008-03-13 Metronidazole-based dermatological foams and emulsions for the preparation thereof

Publications (3)

Publication Number Publication Date
WO2007031620A2 WO2007031620A2 (fr) 2007-03-22
WO2007031620A3 true WO2007031620A3 (fr) 2007-05-03
WO2007031620B1 WO2007031620B1 (fr) 2007-06-21

Family

ID=36601229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/002037 WO2007031620A2 (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation

Country Status (4)

Country Link
US (2) US20090041678A1 (fr)
EP (1) EP1928416A2 (fr)
FR (1) FR2890560B1 (fr)
WO (1) WO2007031620A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3054236A1 (fr) 2011-06-28 2013-01-03 Chemo Research Sl Formulations de gel a base de metronidazole aqueux mucoadhesif a dosage eleve et leur utilisation pour traiter une vaginose bacterienne

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837378A (en) * 1986-01-15 1989-06-06 Curatek Pharmaceuticals, Inc. Topical metronidazole formulations and therapeutic uses thereof
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US6468989B1 (en) * 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
WO2004037225A2 (fr) * 2002-10-25 2004-05-06 Foamix Ltd. Mousse cosmetique et pharmaceutique
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300491A (en) * 1991-10-31 1994-04-05 Apothekernes Laboratorium A.S. Treatment of protozoal infection
WO2005115336A2 (fr) * 2004-05-15 2005-12-08 Collegium Pharmaceutical, Inc. Formulations pulverisables destinees au traitement d'etats dermiques inflammatoires aigus
US20060024243A1 (en) * 2004-08-02 2006-02-02 Agis Industries (1983) Ltd. Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837378A (en) * 1986-01-15 1989-06-06 Curatek Pharmaceuticals, Inc. Topical metronidazole formulations and therapeutic uses thereof
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US6468989B1 (en) * 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
WO2004037225A2 (fr) * 2002-10-25 2004-05-06 Foamix Ltd. Mousse cosmetique et pharmaceutique
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration

Also Published As

Publication number Publication date
US20090041678A1 (en) 2009-02-12
WO2007031620A2 (fr) 2007-03-22
FR2890560B1 (fr) 2011-06-24
FR2890560A1 (fr) 2007-03-16
WO2007031620B1 (fr) 2007-06-21
US20110237637A1 (en) 2011-09-29
EP1928416A2 (fr) 2008-06-11

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