WO2007031621A3 - Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation - Google Patents

Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation Download PDF

Info

Publication number
WO2007031621A3
WO2007031621A3 PCT/FR2006/002038 FR2006002038W WO2007031621A3 WO 2007031621 A3 WO2007031621 A3 WO 2007031621A3 FR 2006002038 W FR2006002038 W FR 2006002038W WO 2007031621 A3 WO2007031621 A3 WO 2007031621A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass
metronidazole
emulsions
production
based dermatological
Prior art date
Application number
PCT/FR2006/002038
Other languages
English (en)
Other versions
WO2007031621B1 (fr
WO2007031621A2 (fr
Inventor
Dov Tamarkin
Doron Friedman
Original Assignee
Galderma Sa
Dov Tamarkin
Doron Friedman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa, Dov Tamarkin, Doron Friedman filed Critical Galderma Sa
Priority to CA2619474A priority Critical patent/CA2619474C/fr
Priority to EP06808066A priority patent/EP1928417A2/fr
Publication of WO2007031621A2 publication Critical patent/WO2007031621A2/fr
Publication of WO2007031621A3 publication Critical patent/WO2007031621A3/fr
Publication of WO2007031621B1 publication Critical patent/WO2007031621B1/fr
Priority to US12/076,114 priority patent/US20090053146A1/en
Priority to US13/154,478 priority patent/US20110237638A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des émulsions comprenant, en pourcentage en masse par rapport à la masse totale de la composition : (a) 72% à 76% d'eau ; (b) 0,1% à 5% d'un agent gélifiant de la phase aqueuse de l’émulsion ; (c) 0,75% à 2% de métronidazole ; (d) 5% à 10% d'huile minérale ; (e) 0,5% à 10% d'un agent tensioactif ; (f) 0,5% à 5% d'un acide gras ; (g) 0% à 4% d'un promoteur d'absorption du métronidazole (c) ; et (h) 0,1% à 5% d'un agent conservateur choisi parmi le groupe constitué par le méthylparabène, le propylparabène, le phénoxyéthanol et leurs mélanges. L'invention concerne également des mousses à base de métronidazole obtenues à partir de ces émulsions, ainsi que leur utilisation dermatologique.
PCT/FR2006/002038 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation WO2007031621A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2619474A CA2619474C (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation
EP06808066A EP1928417A2 (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation
US12/076,114 US20090053146A1 (en) 2005-09-13 2008-03-13 Metronidazole-based dermatological foams and emulsions for the preparation thereof
US13/154,478 US20110237638A1 (en) 2005-09-13 2011-06-07 Metronidazole-based dermatological foam and emulsions for the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0509340 2005-09-13
FR0509340A FR2890559B1 (fr) 2005-09-13 2005-09-13 Mousses dermatologiques a base de metronidazole et emulsions pour la preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/076,114 Continuation US20090053146A1 (en) 2005-09-13 2008-03-13 Metronidazole-based dermatological foams and emulsions for the preparation thereof

Publications (3)

Publication Number Publication Date
WO2007031621A2 WO2007031621A2 (fr) 2007-03-22
WO2007031621A3 true WO2007031621A3 (fr) 2007-05-03
WO2007031621B1 WO2007031621B1 (fr) 2007-06-21

Family

ID=36592928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/002038 WO2007031621A2 (fr) 2005-09-13 2006-09-05 Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation

Country Status (5)

Country Link
US (2) US20090053146A1 (fr)
EP (1) EP1928417A2 (fr)
CA (1) CA2619474C (fr)
FR (1) FR2890559B1 (fr)
WO (1) WO2007031621A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
AU2003279493B2 (en) 2002-10-25 2009-08-20 Foamix Pharmaceuticals Ltd. Cosmetic and pharmaceutical foam
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
GB2449973B8 (en) * 2007-05-31 2010-01-06 Syntopix Group Plc Antibacterial & anti-acne formulations containing dialkyl sulphosuccinates
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (fr) 2007-11-30 2009-06-04 Foamix Ltd. Peroxyde de benzoyle contenant de la mousse
WO2010041141A2 (fr) 2008-10-07 2010-04-15 Foamix Ltd. Support expansible à base d’huile et préparations
WO2009072007A2 (fr) 2007-12-07 2009-06-11 Foamix Ltd. Porteurs, formulations, procédés pour formuler des agents actifs instables pour application externe et utilisations associées
WO2009090558A2 (fr) 2008-01-14 2009-07-23 Foamix Ltd. Compositions pharmaceutiques pouvant mousser de poloxamère avec des agents actifs et/ou des cellules thérapeutiques, et utilisations
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
CA2769625C (fr) 2009-07-29 2017-04-11 Foamix Ltd. Compositions hydro-alcooliques moussantes non tensioactives, mousses legeres, et leurs utilisations
WO2011013008A2 (fr) 2009-07-29 2011-02-03 Foamix Ltd. Compositions hydro-alcooliques moussantes à base d'agents non tensioactifs non polymères, mousses légères, et leurs utilisations
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
CN102686205A (zh) 2009-10-02 2012-09-19 弗艾米克斯有限公司 局部四环素组合物
CN107823123A (zh) 2011-06-28 2018-03-23 化学研究有限公司 高剂量粘膜粘附甲硝唑水基凝胶制剂及其治疗细菌性阴道病的用途
MX2017011630A (es) 2016-09-08 2018-09-25 Foamix Pharmaceuticals Ltd Composiciones y metodos para tratar rosacea y acne.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837378A (en) * 1986-01-15 1989-06-06 Curatek Pharmaceuticals, Inc. Topical metronidazole formulations and therapeutic uses thereof
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US6468989B1 (en) * 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
WO2004037225A2 (fr) * 2002-10-25 2004-05-06 Foamix Ltd. Mousse cosmetique et pharmaceutique
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300491A (en) * 1991-10-31 1994-04-05 Apothekernes Laboratorium A.S. Treatment of protozoal infection
WO2005115336A2 (fr) * 2004-05-15 2005-12-08 Collegium Pharmaceutical, Inc. Formulations pulverisables destinees au traitement d'etats dermiques inflammatoires aigus
US20060024243A1 (en) * 2004-08-02 2006-02-02 Agis Industries (1983) Ltd. Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837378A (en) * 1986-01-15 1989-06-06 Curatek Pharmaceuticals, Inc. Topical metronidazole formulations and therapeutic uses thereof
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US6468989B1 (en) * 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
WO2004037225A2 (fr) * 2002-10-25 2004-05-06 Foamix Ltd. Mousse cosmetique et pharmaceutique
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration

Also Published As

Publication number Publication date
WO2007031621B1 (fr) 2007-06-21
FR2890559A1 (fr) 2007-03-16
CA2619474C (fr) 2012-01-10
WO2007031621A2 (fr) 2007-03-22
FR2890559B1 (fr) 2011-06-24
CA2619474A1 (fr) 2007-03-22
EP1928417A2 (fr) 2008-06-11
US20110237638A1 (en) 2011-09-29
US20090053146A1 (en) 2009-02-26

Similar Documents

Publication Publication Date Title
WO2007031621A3 (fr) Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation
WO2002055608A3 (fr) Composition moussante thermogelifiante et mousse obtenue
WO2007039825A3 (fr) Compositions expansibles saccharidiques
WO2011115700A3 (fr) Mousses émollientes pour le traitement de dermatite séborrhéique
WO2008139908A1 (fr) Composition d'émulsion huile-dans-eau et sa méthode de préparation
WO2008030949A3 (fr) Émulsions d'acides gras polyinsaturés stables et procédés permettant d'inhiber, de supprimer ou de réduire la dégradation des acides gras polyinsaturés dans une émulsion
WO2008018045A3 (fr) composition de soins personnels
WO2008061899A3 (fr) Formulations agrochimiques à base d'eau liquide
BRPI0201235B1 (pt) composição cosmética multifásica
WO2007036376A3 (fr) Produits pour le soin de la peau
WO2010017108A3 (fr) Emulsions de poix
WO2007147904A3 (fr) Émulsifiants h/e, émulsions h/e, et procédé de production correspondant
WO2007022114A3 (fr) Composition hydrofuge pour l’amélioration de la stabilité dimensionnelle de produits en bois
WO2007133769A3 (fr) Compositions d'émulsions eau dans l'huile contenant des agents actifs antisolaires et des siloxanes élastomères
WO2008096497A1 (fr) Composition en émulsion pour une préparation destinée à être appliquée sur les cheveux
MX2007010700A (es) Composiciones de herbicidas que contienen limoneno, formulaciones de concentrados de herbicidas y metodos para fabricar y usar las mismas.
IL189129A0 (en) Aerated compositions comprising hydrophobin
WO2009027867A3 (fr) Compositions moussantes
WO2007059888A3 (fr) Emulsions speciales
WO2010052072A4 (fr) Composition
WO2008143090A1 (fr) Composition d'émulsion de type eau dans huile
WO2009019891A1 (fr) Vesicule inversée
WO2005004820A3 (fr) Composition
WO2005089522A3 (fr) Proprietes spermicides et virocides de differentes formes de sophorolipides
ATE429824T1 (de) Lebensmittelschaum, stabilisiert durch kleine, feste partikel

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006808066

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2619474

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWP Wipo information: published in national office

Ref document number: 2006808066

Country of ref document: EP