WO2007031621B1 - Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation - Google Patents
Mousses dermatologiques a base de metronidazole et emulsions pour leur preparationInfo
- Publication number
- WO2007031621B1 WO2007031621B1 PCT/FR2006/002038 FR2006002038W WO2007031621B1 WO 2007031621 B1 WO2007031621 B1 WO 2007031621B1 FR 2006002038 W FR2006002038 W FR 2006002038W WO 2007031621 B1 WO2007031621 B1 WO 2007031621B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mass
- metronidazole
- emulsions
- production
- dermatological foam
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des émulsions comprenant, en pourcentage en masse par rapport à la masse totale de la composition : (a) 72% à 76% d'eau ; (b) 0,1% à 5% d'un agent gélifiant de la phase aqueuse de l’émulsion ; (c) 0,75% à 2% de métronidazole ; (d) 5% à 10% d'huile minérale ; (e) 0,5% à 10% d'un agent tensioactif ; (f) 0,5% à 5% d'un acide gras ; (g) 0% à 4% d'un promoteur d'absorption du métronidazole (c) ; et (h) 0,1% à 5% d'un agent conservateur choisi parmi le groupe constitué par le méthylparabène, le propylparabène, le phénoxyéthanol et leurs mélanges. L'invention concerne également des mousses à base de métronidazole obtenues à partir de ces émulsions, ainsi que leur utilisation dermatologique.
Claims
1. Composition à base de métronidazole choisie parmi les compositions suivantes :
2. Utilisation d'une composition selon la revendication 1, pour la préparation d'une mousse dermatologique destinée au traitement prophylactique ou thérapeutique d'une affection cutanée, par voie topique.
3. Utilisation selon la revendication 2, pour la préparation d'une mousse dermatologique destinée au traitement de la rosacée.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2619474A CA2619474C (fr) | 2005-09-13 | 2006-09-05 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
EP06808066A EP1928417A2 (fr) | 2005-09-13 | 2006-09-05 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
US12/076,114 US20090053146A1 (en) | 2005-09-13 | 2008-03-13 | Metronidazole-based dermatological foams and emulsions for the preparation thereof |
US13/154,478 US20110237638A1 (en) | 2005-09-13 | 2011-06-07 | Metronidazole-based dermatological foam and emulsions for the preparation thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0509340 | 2005-09-13 | ||
FR0509340A FR2890559B1 (fr) | 2005-09-13 | 2005-09-13 | Mousses dermatologiques a base de metronidazole et emulsions pour la preparation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/076,114 Continuation US20090053146A1 (en) | 2005-09-13 | 2008-03-13 | Metronidazole-based dermatological foams and emulsions for the preparation thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2007031621A2 WO2007031621A2 (fr) | 2007-03-22 |
WO2007031621A3 WO2007031621A3 (fr) | 2007-05-03 |
WO2007031621B1 true WO2007031621B1 (fr) | 2007-06-21 |
Family
ID=36592928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2006/002038 WO2007031621A2 (fr) | 2005-09-13 | 2006-09-05 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
Country Status (5)
Country | Link |
---|---|
US (2) | US20090053146A1 (fr) |
EP (1) | EP1928417A2 (fr) |
CA (1) | CA2619474C (fr) |
FR (1) | FR2890559B1 (fr) |
WO (1) | WO2007031621A2 (fr) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8435498B2 (en) | 2002-10-25 | 2013-05-07 | Foamix Ltd. | Penetrating pharmaceutical foam |
US8486375B2 (en) | 2003-04-28 | 2013-07-16 | Foamix Ltd. | Foamable compositions |
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
US8518378B2 (en) | 2003-08-04 | 2013-08-27 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US8618081B2 (en) | 2009-10-02 | 2013-12-31 | Foamix Ltd. | Compositions, gels and foams with rheology modulators and uses thereof |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US8709385B2 (en) | 2008-01-14 | 2014-04-29 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
US8722021B2 (en) | 2002-10-25 | 2014-05-13 | Foamix Ltd. | Foamable carriers |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US9072667B2 (en) | 2009-07-29 | 2015-07-07 | Foamix Pharmaceuticals Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
US9101662B2 (en) | 2003-08-04 | 2015-08-11 | Foamix Pharmaceuticals Ltd. | Compositions with modulating agents |
US9161916B2 (en) | 2007-12-07 | 2015-10-20 | Foamix Pharmaceuticals Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
US9167813B2 (en) | 2009-07-29 | 2015-10-27 | Foamix Pharmaceuticals Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US9320705B2 (en) | 2002-10-25 | 2016-04-26 | Foamix Pharmaceuticals Ltd. | Sensation modifying topical composition foam |
US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
US9539208B2 (en) | 2002-10-25 | 2017-01-10 | Foamix Pharmaceuticals Ltd. | Foam prepared from nanoemulsions and uses |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
EP2152260A1 (fr) * | 2007-05-31 | 2010-02-17 | Syntopix Group plc | Formulation antibactérienne contenant du sulphosuccinate de dialkyle et un agent antibactérien à base de diphénylcarbamide |
CA2760186C (fr) | 2009-04-28 | 2019-10-29 | Foamix Ltd. | Vehicule moussant et compositions pharmaceutiques comportant des solvants polaires aprotiques et leurs utilisations |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
CN103763925A (zh) | 2011-06-28 | 2014-04-30 | 梅迪奇制药有限公司 | 高剂量粘膜粘附甲硝唑水基凝胶制剂及其治疗细菌性阴道病的用途 |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837378A (en) * | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
US5536743A (en) * | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
US5300491A (en) * | 1991-10-31 | 1994-04-05 | Apothekernes Laboratorium A.S. | Treatment of protozoal infection |
US6468989B1 (en) * | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
KR101108439B1 (ko) * | 2002-10-25 | 2012-01-31 | 포믹스 리미티드 | 화장료 및 약제용 거품제 |
JP2007503428A (ja) * | 2003-08-25 | 2007-02-22 | フォーミックス エルティーディー. | 浸透性医薬発泡剤 |
WO2005115336A2 (fr) * | 2004-05-15 | 2005-12-08 | Collegium Pharmaceutical, Inc. | Formulations pulverisables destinees au traitement d'etats dermiques inflammatoires aigus |
US20060024243A1 (en) * | 2004-08-02 | 2006-02-02 | Agis Industries (1983) Ltd. | Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same |
-
2005
- 2005-09-13 FR FR0509340A patent/FR2890559B1/fr not_active Expired - Fee Related
-
2006
- 2006-09-05 EP EP06808066A patent/EP1928417A2/fr not_active Withdrawn
- 2006-09-05 CA CA2619474A patent/CA2619474C/fr not_active Expired - Fee Related
- 2006-09-05 WO PCT/FR2006/002038 patent/WO2007031621A2/fr active Application Filing
-
2008
- 2008-03-13 US US12/076,114 patent/US20090053146A1/en not_active Abandoned
-
2011
- 2011-06-07 US US13/154,478 patent/US20110237638A1/en not_active Abandoned
Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US9539208B2 (en) | 2002-10-25 | 2017-01-10 | Foamix Pharmaceuticals Ltd. | Foam prepared from nanoemulsions and uses |
US9492412B2 (en) | 2002-10-25 | 2016-11-15 | Foamix Pharmaceuticals Ltd. | Penetrating pharmaceutical foam |
US9320705B2 (en) | 2002-10-25 | 2016-04-26 | Foamix Pharmaceuticals Ltd. | Sensation modifying topical composition foam |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US8435498B2 (en) | 2002-10-25 | 2013-05-07 | Foamix Ltd. | Penetrating pharmaceutical foam |
US8722021B2 (en) | 2002-10-25 | 2014-05-13 | Foamix Ltd. | Foamable carriers |
US8741265B2 (en) | 2002-10-25 | 2014-06-03 | Foamix Ltd. | Penetrating pharmaceutical foam |
US8840869B2 (en) | 2002-10-25 | 2014-09-23 | Foamix Ltd. | Body cavity foams |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US8486375B2 (en) | 2003-04-28 | 2013-07-16 | Foamix Ltd. | Foamable compositions |
US8703105B2 (en) | 2003-08-04 | 2014-04-22 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US9050253B2 (en) | 2003-08-04 | 2015-06-09 | Foamix Pharmaceuticals Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US8518378B2 (en) | 2003-08-04 | 2013-08-27 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US9101662B2 (en) | 2003-08-04 | 2015-08-11 | Foamix Pharmaceuticals Ltd. | Compositions with modulating agents |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
US9161916B2 (en) | 2007-12-07 | 2015-10-20 | Foamix Pharmaceuticals Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
US9549898B2 (en) | 2007-12-07 | 2017-01-24 | Foamix Pharmaceuticals Ltd. | Oil and liquid silicone foamable carriers and formulations |
US8709385B2 (en) | 2008-01-14 | 2014-04-29 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
US9072667B2 (en) | 2009-07-29 | 2015-07-07 | Foamix Pharmaceuticals Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
US9167813B2 (en) | 2009-07-29 | 2015-10-27 | Foamix Pharmaceuticals Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
US9572775B2 (en) | 2009-07-29 | 2017-02-21 | Foamix Pharmaceuticals Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
US8992896B2 (en) | 2009-10-02 | 2015-03-31 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
US8945516B2 (en) | 2009-10-02 | 2015-02-03 | Foamix Pharmaceuticals Ltd. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
US8618081B2 (en) | 2009-10-02 | 2013-12-31 | Foamix Ltd. | Compositions, gels and foams with rheology modulators and uses thereof |
US8871184B2 (en) | 2009-10-02 | 2014-10-28 | Foamix Ltd. | Topical tetracycline compositions |
US8865139B1 (en) | 2009-10-02 | 2014-10-21 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
Also Published As
Publication number | Publication date |
---|---|
US20110237638A1 (en) | 2011-09-29 |
CA2619474C (fr) | 2012-01-10 |
EP1928417A2 (fr) | 2008-06-11 |
FR2890559A1 (fr) | 2007-03-16 |
US20090053146A1 (en) | 2009-02-26 |
CA2619474A1 (fr) | 2007-03-22 |
WO2007031621A2 (fr) | 2007-03-22 |
FR2890559B1 (fr) | 2011-06-24 |
WO2007031621A3 (fr) | 2007-05-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007031621B1 (fr) | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation | |
JP2019081783A5 (fr) | ||
WO2006005731A3 (fr) | Nouveau latex inverse a faible teneur en monomere presentant un groupe fonctionnel acide fort, et son utilisation dans la production de compositions topiques | |
WO2007017118B1 (fr) | Composition rinçable pour la peau qui comprend de l'amidon non pregelatinise et un acide gras | |
WO2006034154A3 (fr) | Sels de 5-azacytidine | |
FR2914647B1 (fr) | Copolymere comprenant des unites betainiques et des unites hydrophobes et/ou amphiphiles,procede de preparation,et utilisations. | |
WO2005080313A3 (fr) | Derives de sulfonamides utilises dans le traitement de maladies | |
BRPI0408516A (pt) | composições autoemulsificantes, métodos de uso e preparação | |
WO2002055608A3 (fr) | Composition moussante thermogelifiante et mousse obtenue | |
EP1437118A1 (fr) | Base pour preparations dermatologiques externes et produits cosmetiques la contenant | |
DE10234885B4 (de) | Kosmetische und/oder dermatologische Silikon-in Wasser-Emulsionen und transparentes Packmittel enthaltend diese Sonnenschutzzubereitungen | |
WO2006005611A3 (fr) | Composes organiques | |
WO2005106491A3 (fr) | Diagnostic et traitement therapeutique de maladies associees a la kinase 1 regulee par serum/glucocorticoide (sgk1) | |
WO2005040828A3 (fr) | Agents de diagnostic et de traitement des maladies associees au recepteur 49 couple aux proteines g (gpr49) | |
WO2007031620B1 (fr) | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation | |
WO2006010514A3 (fr) | Diagnostic et traitement therapeutique des maladies associees a la proteine kinase kinase 5 activee par les mitogenes (map2k5) a double specificite | |
BRPI0513763A (pt) | processo e composições para o desengorduramento de couros, peles, couro não curtido, produtos intermediários de couro e couro não acabado | |
WO2005106488A3 (fr) | Diagnostics et therapeutique de maladies associees a l'adrenorecepteur beta-2 couple aux proteines g (adrb2) | |
DE20016125U1 (de) | Nasensalbe auf Basis von Vaselin mit Gerbstoffen | |
DE102005011626A1 (de) | Antibakterieller Wirkkomplex für ölfreie Zubereitungen | |
WO2003090916A3 (fr) | Preparation d'une emulsion par dilution d'un concentre emulsionnable comprenant un copolymere amphiphile | |
DE602004027629D1 (de) | d-(17alpha)-13-ETHYL-17HYDROXY-18,19-DINORPREGN-4-ENE-20-YNE-3-ONE IN FORM DES REINEN 3E- UND 3Z-OXIMES SOWIE DAS VERFAHREN ZUR HERSTELLUNG DER MISCHU | |
EP1312608A3 (fr) | Analogues de discodermolide et leur utilisation pharmaceutique | |
WO2003097100A1 (fr) | Composition topique de traitement d'etats inflammatoires de la peau | |
DE29924428U1 (de) | Dimeticon enthaltende Aciclovirzusammensetzungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2006808066 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2619474 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWP | Wipo information: published in national office |
Ref document number: 2006808066 Country of ref document: EP |