WO2006133397A3 - Procede permettant de realiser la synthese de triazoles - Google Patents

Procede permettant de realiser la synthese de triazoles Download PDF

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Publication number
WO2006133397A3
WO2006133397A3 PCT/US2006/022424 US2006022424W WO2006133397A3 WO 2006133397 A3 WO2006133397 A3 WO 2006133397A3 US 2006022424 W US2006022424 W US 2006022424W WO 2006133397 A3 WO2006133397 A3 WO 2006133397A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
triazoles
synthesis
combining
Prior art date
Application number
PCT/US2006/022424
Other languages
English (en)
Other versions
WO2006133397A2 (fr
Inventor
Shili Chen
Rongliang Lou
Yusheng Wu
Jiacheng Zhou
Roger Hanselmann
Original Assignee
Rib X Pharmaceuticals Inc
Shili Chen
Rongliang Lou
Yusheng Wu
Jiacheng Zhou
Roger Hanselmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib X Pharmaceuticals Inc, Shili Chen, Rongliang Lou, Yusheng Wu, Jiacheng Zhou, Roger Hanselmann filed Critical Rib X Pharmaceuticals Inc
Priority to JP2008515957A priority Critical patent/JP5534497B2/ja
Priority to DE602006019870T priority patent/DE602006019870D1/de
Priority to US11/921,838 priority patent/US8399660B2/en
Priority to EP06784685A priority patent/EP1904489B1/fr
Priority to KR1020087000377A priority patent/KR101394307B1/ko
Priority to AT06784685T priority patent/ATE496914T1/de
Publication of WO2006133397A2 publication Critical patent/WO2006133397A2/fr
Publication of WO2006133397A3 publication Critical patent/WO2006133397A3/fr
Priority to US13/845,759 priority patent/US8796465B2/en
Priority to US14/325,248 priority patent/US9376400B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des procédés de préparation de triazoles. Ces composés sont utiles comme agents anti-infectieux, anti-prolifératifs, anti-inflammatoires et pro-cinétiques.
PCT/US2006/022424 2005-06-08 2006-06-08 Procede permettant de realiser la synthese de triazoles WO2006133397A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2008515957A JP5534497B2 (ja) 2005-06-08 2006-06-08 トリアゾール類の合成方法
DE602006019870T DE602006019870D1 (de) 2005-06-08 2006-06-08 Verfahren zur synthese von triazolen
US11/921,838 US8399660B2 (en) 2005-06-08 2006-06-08 Process for the synthesis of triazoles
EP06784685A EP1904489B1 (fr) 2005-06-08 2006-06-08 Procede permettant de realiser la synthese de triazoles
KR1020087000377A KR101394307B1 (ko) 2005-06-08 2006-06-08 트리아졸의 합성 방법
AT06784685T ATE496914T1 (de) 2005-06-08 2006-06-08 Verfahren zur synthese von triazolen
US13/845,759 US8796465B2 (en) 2005-06-08 2013-03-18 Process for the syntheses of triazoles
US14/325,248 US9376400B2 (en) 2005-06-08 2014-07-07 Process for the synthesis of triazoles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68899005P 2005-06-08 2005-06-08
US60/688,990 2005-06-08

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/921,838 A-371-Of-International US8399660B2 (en) 2005-06-08 2006-06-08 Process for the synthesis of triazoles
US13/845,759 Continuation US8796465B2 (en) 2005-06-08 2013-03-18 Process for the syntheses of triazoles

Publications (2)

Publication Number Publication Date
WO2006133397A2 WO2006133397A2 (fr) 2006-12-14
WO2006133397A3 true WO2006133397A3 (fr) 2007-05-24

Family

ID=37450902

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/022424 WO2006133397A2 (fr) 2005-06-08 2006-06-08 Procede permettant de realiser la synthese de triazoles

Country Status (7)

Country Link
US (3) US8399660B2 (fr)
EP (1) EP1904489B1 (fr)
JP (2) JP5534497B2 (fr)
KR (1) KR101394307B1 (fr)
AT (1) ATE496914T1 (fr)
DE (1) DE602006019870D1 (fr)
WO (1) WO2006133397A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
WO2007133803A2 (fr) * 2006-05-15 2007-11-22 Rib-X Pharmaceuticals, Inc. Traitement d'infections mycobactériennes
WO2010005127A2 (fr) * 2008-07-09 2010-01-14 Postech Academy-Industry Foundation Nanocatalyseur de cuivre hétérogène et ses procédés de fabrication
US20100069441A1 (en) 2008-09-02 2010-03-18 Mikhail Fedorovich Gordeev Antimicrobial indoline compounds for treatment of bacterial infections
SG10201508982TA (en) * 2010-11-01 2015-12-30 Melinta Therapeutics Inc Pharmaceutical compositions
US9126991B2 (en) 2012-10-04 2015-09-08 Hui-Yin Li Radezolid salts and polymorphic forms thereof
US10471046B2 (en) 2014-11-14 2019-11-12 Melinta Subsidary Corp. Method for treating, preventing, or reducing the risk of skin infection
WO2016088103A1 (fr) * 2014-12-05 2016-06-09 Sun Pharmaceutical Industries Limited Procédé de préparation de phosphate de tédizolide
US20170333400A1 (en) * 2016-05-17 2017-11-23 Melinta Therapeutics, Inc. Topical formulations of biaryl heterocyclic compounds and methods of use thereof
CN106749074A (zh) * 2016-11-14 2017-05-31 沈阳药科大学 一种联芳基噁唑烷酮中间体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012271A2 (fr) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Procede de synthese d'oxazolidinones de biaryle
WO2005019211A2 (fr) * 2003-06-03 2005-03-03 Rib-X Pharmaceuticals, Inc. Composes heterocycliques biaryle et procedes de production et d'utilisation associes
WO2006133397A2 (fr) * 2005-06-08 2006-12-14 Rib-X Pharmaceuticals, Inc. Procede permettant de realiser la synthese de triazoles

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US5043443A (en) * 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5130316A (en) * 1988-07-29 1992-07-14 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
WO1993009103A1 (fr) * 1991-11-01 1993-05-13 The Upjohn Company Aryl- et heteroarylphenyloxazolidinones substituees, utilisees comme agents antibacteriens
JP3558088B2 (ja) * 1992-12-08 2004-08-25 ファルマシア・アンド・アップジョン・カンパニー トロポン−置換のフェニルオキサゾリジノン抗菌剤
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425612A1 (de) 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
JPH08151577A (ja) 1994-11-30 1996-06-11 Canon Inc 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子、それらを用いた液晶装置及び表示方法
JPH08151578A (ja) 1994-11-30 1996-06-11 Canon Inc 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、液晶装置
HRP970049A2 (en) * 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
SK156499A3 (en) 1997-05-30 2000-06-12 Upjohn Co Oxazolidinone antibacterial agents having a thiocarbonyl functionality
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
AU1694099A (en) 1997-12-26 1999-07-19 Cheil Jedang Corporation Cephem derivatives and a method for producing the compounds and an antibacterialcomposition containing the compounds
US6562844B2 (en) * 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1049682A1 (fr) * 1998-01-23 2000-11-08 Versicor, Inc. Banques combinatoires d'oxazolidinones, compositions a base de tels composes et procedes de preparation
GB9812019D0 (en) 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds
IL140084A0 (en) * 1998-06-05 2002-02-10 Astra Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
AU1379900A (en) 1998-11-17 2000-06-05 Bayer Aktiengesellschaft Novel substituted phenyloxazolidone derivatives
IL147503A0 (en) 1999-07-28 2002-08-14 Upjohn Co Oxazolidinone compounds and methods of preparation and use thereof
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
WO2001032633A1 (fr) * 1999-11-04 2001-05-10 Basilea Pharmaceutica Ag 5-benzyl-2,4-diaminopyrimidines substituees
GB9928499D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical processes and intermediates
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
JP2003535860A (ja) 2000-06-05 2003-12-02 ドン・ア・ファーム・カンパニー・リミテッド 新規なオキサゾリジノン誘導体及びその製造方法
DE10034627A1 (de) 2000-07-17 2002-01-31 Bayer Ag Aryl-substituierte Oxazolidinone mit Cytokin inhibitorischer Wirkung
GB0100102D0 (en) 2001-01-03 2001-02-14 Syngenta Participations Ag Organic compounds
DE60212959T2 (de) 2001-04-07 2007-02-15 Astrazeneca Ab Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika
GB0108764D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108793D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108794D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compound
GB0113297D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
GB0113299D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical process & intermediates
CN1639136A (zh) 2001-09-11 2005-07-13 阿斯特拉曾尼卡有限公司 作为抗菌剂的噁唑烷酮和/或异噁唑啉
GB2396350A (en) 2001-10-25 2004-06-23 Astrazeneca Ab Aryl substituted oxazolidinones with antibacterial activity
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
BR0308056A (pt) 2002-02-28 2004-12-07 Astrazeneca Ab Composto, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto
CN1642543A (zh) 2002-03-29 2005-07-20 法玛西雅厄普约翰有限责任公司 治疗糖尿病性足部感染的噁唑烷酮肠胃外、静脉内和口服给药
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
US20060116400A1 (en) 2002-11-28 2006-06-01 Astrazeneca Ab Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
GB0229518D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229526D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
TW200500360A (en) 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
JP2006522791A (ja) 2003-04-09 2006-10-05 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗微生物性［３．１．０］ビシクロヘキシルフェニルオキサゾリジノン誘導体および類似体
EP1646617A2 (fr) 2003-06-03 2006-04-19 Rib-X Pharmaceuticals, Inc. Composes de sulfamide, procedes de preparation et d'utilisation de ces derniers
WO2005003087A2 (fr) 2003-07-01 2005-01-13 Orchid Chemicals And Pharmaceuticals Ltd. Composes nouveaux utiles comme agents anti-bacteriens
JP4607107B2 (ja) * 2003-07-02 2011-01-05 メルク・シャープ・エンド・ドーム・コーポレイション シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体
JP2007500707A (ja) 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法
TW200526649A (en) * 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005019211A2 (fr) * 2003-06-03 2005-03-03 Rib-X Pharmaceuticals, Inc. Composes heterocycliques biaryle et procedes de production et d'utilisation associes
WO2005012271A2 (fr) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Procede de synthese d'oxazolidinones de biaryle
WO2006133397A2 (fr) * 2005-06-08 2006-12-14 Rib-X Pharmaceuticals, Inc. Procede permettant de realiser la synthese de triazoles

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE BEILSTEIN 2003, XP002414554, Database accession no. Reaction ID: 9587342 *
FAHMI HIMO ET AL: "Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, no. 1, 8 December 2004 (2004-12-08), pages 210 - 216, XP002414550 *
HERNÁN A. ORGUEIRA ET AL: "Regioselective synthesis of [1,2,3]-triazoles catalyzed by Cu(I) generated in situ from Cu(0) nanosize activated powder and amine hydrochloride salts", REGIOSELECTIVE SYNTHESIS OF [1,2,3]-TRIAZOLES CATALYZED BY CU(I) GENERATED IN SITU FROM CU(0) NANOSIZE ACTIVATED POWDER AND AMINE HYDROCHLORIDE SALTS, vol. 46, no. 16, 10 March 2005 (2005-03-10), pages 2911 - 2914, XP002414549 *
VERKHOZINA, O. N. ET AL, RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 39, no. 12, 2003, pages 1863 - 1867 *
VSEVOLOD V. ROSTOVTSEV ET AL: "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective Ligation of Azides and Terminal Alkynes", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 41, no. 14, 2002, pages 2596 - 2599, XP002414552 *
WU, PENG ET AL: "Efficiency and Fidelity in a Click-Chemistry Route to Triazole Dendrimers by the Copper(I)-Catalyzed Ligation of Azides and Alkynes", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 43, no. 30, 2004, pages 3928 - 3932, XP002414551 *

Also Published As

Publication number Publication date
JP5923457B2 (ja) 2016-05-24
US9376400B2 (en) 2016-06-28
EP1904489B1 (fr) 2011-01-26
JP2013129680A (ja) 2013-07-04
KR20080020669A (ko) 2008-03-05
ATE496914T1 (de) 2011-02-15
KR101394307B1 (ko) 2014-05-13
JP5534497B2 (ja) 2014-07-02
US20100234615A1 (en) 2010-09-16
US20140031402A1 (en) 2014-01-30
DE602006019870D1 (de) 2011-03-10
US8399660B2 (en) 2013-03-19
EP1904489A2 (fr) 2008-04-02
WO2006133397A2 (fr) 2006-12-14
JP2008545798A (ja) 2008-12-18
US8796465B2 (en) 2014-08-05
US20150158827A1 (en) 2015-06-11

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