WO2006062273A1 - Complement alimentaire d'acides amines ramifies - Google Patents

Complement alimentaire d'acides amines ramifies Download PDF

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Publication number
WO2006062273A1
WO2006062273A1 PCT/KR2005/000517 KR2005000517W WO2006062273A1 WO 2006062273 A1 WO2006062273 A1 WO 2006062273A1 KR 2005000517 W KR2005000517 W KR 2005000517W WO 2006062273 A1 WO2006062273 A1 WO 2006062273A1
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WIPO (PCT)
Prior art keywords
liv
amino acids
vitamin
food
weight
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PCT/KR2005/000517
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English (en)
Inventor
Se-Gyu Kim
Ji-Hyun Kim
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Se-Gyu Kim
Ji-Hyun Kim
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Publication of WO2006062273A1 publication Critical patent/WO2006062273A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/02—Acid
    • A23V2250/06—Amino acid

Definitions

  • the present invention relates to a health supplement food utilizing, in particular, branched amino acids from among essential amino acids. More specifically, the present invention relates to: a health supplement food comprising branched chain amino acids (hereinafter, referred to as LIV) composed of leucine (L), isoleucine (I) and valine (V) which is made to have a composition similar to essential amino acids contained in naturally-occurring milk, eggs, soybeans, beef and the like, and enhancing instant impact power under anaerobic conditions, via addition of L-glutamine and taurine which are essentially required when a person is exposed to excessive exercise, stress or overwork; a health supplement food for improving a weak constitution, comprising herbal materials such as ginseng, red ginseng and Acanthopanax; and a diet food or beverage further comprising dietary fibers such as inulin, polydextrose and crystalline cellulose, and carnitine and hydroxy citric acid.
  • LIV branched chain amino acids
  • LIV branche
  • Important factors that should be considered in exercises include, firstly mind control to do exercise, secondly proper nutrition and thirdly sufficient rest.
  • mind control to do exercise and taking sufficient rest can be solved by whether or not individual people make effort and make time for relaxation, but proper nutrition is another problem.
  • Japanese Patent Laid-Open Publication No. Sho 60-049764 discloses a food composition for strengthening muscular power of an athlete, comprising amino acids composed of isoleucine:leucine:valine:arginine in a ratio of 1.3 to 0.6 : 1 : 0.4 to 0.8 : 1.4 to 0.6, and further proteins at a content of not less than 30%.
  • Hei 9-052828 discloses an amino acid composition comprised essentially of leucine, wherein 5-20% by weight of valine, 5-20% by weight of leucine, 5-20% by weight of isoleucine, 3-20% by weight of lysine, 5-20% by weight of threonine, 3-20% by weight of methionine, 2-10% by weight of histidine, 1-10% by weight of phenylalanine, 1-10% by weight of tryptophan, 5-30% by weight of arginine, 5-30% by weight of glutamine and 2-10% by weight of proline are contained.
  • WO 97/25883 discloses an amino acid preparation for stimulating hair growth, comprising the amino acids valine : leucine : isoleucine : proline in a ratio of 22:44:30:4.
  • Korean Patent Laid-Open Publication No. 10-2003-0013836 published on Feb. 15, 2003, Application No.
  • 10-2001-0048037 discloses a nutritional supplement food for sportsmen, comprising a mixture of powdered maltodextrin, fructose, glucose, protein, collagen (gelatin), taurine, L- glutamine, citric acid, glucosamine, vitamins, porcine chondroitin, Vegetable Wasps and Plant Worms (Cordyceps), L-carnitine, amino silk, Karamix, guar gum, Genevia, octacosanol, gardenia green and fruit flavor.
  • Protein is one of particularly important nutrients for athletes and therefore athletes should ingest an adequate amount of protein.
  • the reason why athletes should consume larger amounts of protein than ordinary people is to compensate for a break down of muscle into its original state and to induce active synthesis of protein at a recovery stage after performing exercise because protein is utilized as an energy source during exercise and particularly degradation of muscle protein is active and rapid for weight training.
  • the present inventors have undertaken a great deal of research regarding composition of essential amino acids contained in a variety of foodstuffs and a minimum requirement of essential amino acids for infants, children and adults, respectively. Based on the results thus obtained, the present inventors have recognized the fact that absorption/digestion patterns of Koreans are dependent upon levels and composition of branched chain amino acids contained in dietary foods such as milk, eggs, soybean, beef, wheat and the like, rather than daily requirement of branched chain amino acids presented by Recommended Dietary Allowances (RDA) for Koreans and therefore have developed a supplement food in which branched chain amino acids are contained in compliance with an average ratio of branched chain amino acids contained in the above-mentioned foods.
  • RDA Recommended Dietary Allowances
  • the present inventors have developed a health supplement food for improving a weak constitution by adding herbal materials such as ginseng, red ginseng and Acanthopanax to branched chain amino acids, and have developed a health supplement food for dieting by addition of dietary fibers and appetite-related substances.
  • the supplement food in accordance with the present invention can be utilized as a health supplement food that improves athletic ability of leisure and professional sportsmen enjoying or taking part in individual competition events such as golf, Taekwondo and martial arts.
  • the supplement food in accordance with the present invention can be utilized as a health supplement food that enhances adaptability of ordinary people to intensity of physical labor and results athletes being able to train more, thereby enhancing quality of labor and improving quality of exercise.
  • the supplement food in accordance with the present invention has effects regarding a decrease of blood glucose and increases amounts of amino acids in muscles and thereby can be utilized as a health supplement food such as a scientific nutritional agent for a diabetic.
  • the supplement food in accordance with the present invention can be utilized as a health supplement food capable of overcoming a variety of disorders resulting from physical fatigue.
  • the health supplement food for improving a weak constitution comprising herbal materials such as ginseng, red ginseng and Acanthopanax is expected to have effects on people in need of improvement of weak constitution, maintenance of a healthy body and improvement of body functions.
  • the diet food or beverage further comprising dietary fibers such as inulin, polydextrose and crystalline cellulose, and carnitine and hydroxy citric acid is expected to have significant effects on people who desire to follow a dieting regimen, particularly via loss of body fat around the abdomen region.
  • Fig. 1 is a graph showing serum levels of amino acids in the respective experimental groups obtained from studies in accordance with the present invention.
  • FIG. 2 is a graph showing serum levels of amino acids in the respective experimental groups obtained from studies in accordance with the present invention. Best Mode for Carrying Out the Invention
  • the diet beverage is comprised of 5.5% inulin dietary fiber (dietary fiber content: more than 90%), 5% xylitol, 3.4% polydextrose (dietary fiber content: more than 90%), 1.5% Garcinia cambogia bark extract powder (HCA: more than 50%), 0.5% citric acid, 0.40% L-leucine, 0.26% L-valine, 0.25% L-glutamine, 0.22% L-isoleucine, 0.13% taurine, 0.1% pineapple flavor, 0.05% vitamin C, 0.03% L-carnitine, 0.02% purified salt, 0.004% aspartame, 0.004% sucralose, 0.001% grapefruit seed extract (DF- 100), 0.001% vitamin Bl hydrochloride, 0.001% vitamin B2, 0.001% vitamin B6 hydrochloride, and 82.628% purified water, thereby making the total of 100%.
  • the diet beverage containing dietary fibers as described above increases the quantity of amino acids in the muscle, inhibits absorption of fat, and activates intestinal motility by dietary fibers, which results in burning of abdominal fat and thus is helpful for dieting.
  • LIV leucine
  • I isoleucine
  • valine which converts glucose of the liver and muscle into energy
  • LIV comprises about 70% of muscle proteins and is consumed during prolonged intensive exercise as like glycogen.
  • carbohydrates are known as an energy source that is primarily used when exercising, a great deal of attention has been directed to a LIV supplement known to offset against destruction of muscle proteins due to heavy exercise.
  • an experimental protocol capable of eliciting exact results on studies of LIV, thus raising many different views.
  • Many experts recognize the fact that an uptake of LIV after exercise has beneficial effects on recovery of physical strength.
  • Leucine, isoleucine and valine should maintain balance between one another [41] [42] Leucine, isoleucine and valine are called branched chain amino acids as they are entangled like branched chains. In order to achieve key functions of these three essential amino acids, the most important is a balance and mixing ratio therebetween.
  • the health supplement food utilizing branched chain amino acids in accordance with the present invention comprises LIV composed of 45% by weight of leucine, 25% by weight of isoleucine and 30% by weight of valine.
  • the above-mentioned LIV may be composed of 45 to 47% by weight of leucine
  • leucine decreases blood glucose and is utilized as a nutrient in wound healing, isoleucine is necessary for formation of hemoglobin, and valine converts glucose of the liver and muscle into energy.
  • the total branched chain amino acid- supplemented food comprises 65-75% LIV
  • a diet beverage by addition of dietary fibers such as inulin, polydextrose and crystalline cellulose to the LIV, or by addition of L- carnitine and hydroxy citric acid to the LIV.
  • a health supplement food for improving a weak constitution by addition of herbal materials such as ginseng, red ginseng and Acanthopanax to the LIV
  • L-glutamine promotes protein synthesis of muscles, prevents loss of muscles, accelerates a recovery rate of muscles, and assists in fast growth of muscles.
  • L-glutamine is a free amino acid abundantly found in the body and comprises 60% of the total amino acids therein.
  • L-glutamine is synthesized in the body by other amino acids, but is a conditionally-essential amino acid that must be ingested to maintain muscles and prevent a decline of physical strength in athletes since glutamine in muscles is quickly utilized when the body is exposed to stress due to physical training and exercise.
  • Taurine is aminoethylsulfonic acid having properties of ampholyte like amino acids, and exhibits production of bile acid, regulation of cholesterol concentration, regulation of cell membrane ion permeability, anti-oxidative action and inhibition of excessive nerve excitation, as main physiological functions.
  • Taurine is mainly found in cells of cardiac and skeletal muscles, brain and genital organs rather than in body fluid. Taurine has been known as a cardiotonic agent because it weakens contractive force of the heart when a concentration of calcium ions in the heart is below a normal level.
  • taurine reacts with bile acid to form a polymer, thereby alleviating toxicity of bile acid, and assists in absorption of fats in the intestines.
  • Taurine protects cells by removing peroxides and nitrogen oxides, and free groups before they damage the cell membranes. Taurine is most abundant among amino acids present in the brain, and also exhibits nervous sedative effects via inhibition of excessive nerve excitation when nerves are continuously excited, thereby diminishing stress due to exercise.
  • the present invention has improved functions of the branched chain amino acid- supplemented food by adding L-glutamine and taurine, which are essentially required when exposed to excessive exercise, stress or overwork, to LIV.
  • the branched chain amino acid- supplemented food has contained L-glutamine in an amount of 20 to 35% of the weight of LIV and taurine in an amount of 7 to 20% of the weight of LIV.
  • Dietary fibers such as inulin, polydextrose and crystalline cellulose affect bacteria in the large intestine and therefore inhibit action of carcinogenic substances, thus preventing incidence of colon cancer. Those dietary fibers block absorption of cholesterol, thus preventing occurrence of adult diseases, alleviates the feeling of emptiness and retards absorption of foods, thereby filtering cholesterol. Dietary fibers combine with salts which are then discharged outside the body, thereby hindering elevation of blood pressure which is helpful for treatment and prevention of diabetes. Even for obese people, sufficient uptake of fibrous materials provides them a feeling of fullness while inhibiting absorption and digestion of nutrients, thus helping them refrain from excessive eating.
  • L-carnitine is a coenzyme that plays an important role in fatty acid metabolism and is an amino acid derivative. Hydroxy citric acid suppresses appetite, assists in degradation of body fats and blocks synthesis of fats.
  • the present invention has prepared a health supplement food for dieting by adding dietary fibers such as inulin, polydextrose and crystalline cellulose, and L-carnitine and hydroxy citric acid to LIV.
  • dietary fibers such as inulin, polydextrose and crystalline cellulose, and L-carnitine and hydroxy citric acid
  • Ginseng, red ginseng and Acanthopanax heighten vitality of the body and mind, thereby improving a weak constitution, are helpful for recovery from fatigue, activate production of blood in the body, thereby making blood circulation constant and favorable, improve functions or development of the body, calm and stabilize the mind and sprit, thereby strengthening functions of the heart, are useful in getting rid of neurasthenia, neurosis and stress, replenish the body fluid to appease thirst, are useful for strengthening functions of the spleen and diabetes, protect functions of the lung, thereby relieving coughing, assist in prevention and treatment of respiratory diseases, strengthen the stomach and intestines, thus promoting appetite, bind the bowel (stopping diarrhea), reinforce functions of the stomach and intestines, eliminate toxins in the body, thereby rendering rough skin fine and smooth, consequently being efficacious for skin diseases, and relieve furuncles, thereby resulting in detoxification and enhanced resistance against diseases.
  • the present invention provides a health supplement food for improving a weak constitution, prepared by adding ginseng, red ginseng and Acanthopanax to LIV.
  • vitamin C is important for synthesis of collagen (myofiber protein) of connective tissues and assists in absorption and digestion of minerals and iron constituting a cytochrome system which is involved in energy metabolism. Vitamin C removes histamine, a substance which is secreted in response to stress, and therefore plays a crucial role to control conditions of athletes who are tired from consecutive matches.
  • Active oxygen species which are by-products produced during biological activity of the body, normally occur in energy production in the body, metabolic processes of lipids or proteins, catecholamine responses and a variety of inflammatory reactions, but most of them are neutralized by anti-oxidants.
  • radicals and peroxides are known to play a very important role in pathogenesis of various diseases, i.e., cardiovascular diseases such as hypertension, arteriosclerosis and coronary artery diseases, malignant tumors, chronic inflammatory diseases, Parkinson's syndrome, epilepsy, various cerebral trauma, cataracts, skin cancers and auto-immune diseases.
  • the active oxygen species generated by continuous prolonged exercises under the conditions at which athletes are subjected to heavy stress, lead to changes in fluidity, permeability and excitability of cell membranes or changes in functions of enzymes bound to the cell membranes.
  • all of the materials constituting the body are susceptible to oxidative stress by active oxygen species, and representative examples of such materials include lipids, proteins, DNA, nucleic acids and enzymes. When those materials have suffered oxidative damage, this results in deterioration of cell functions.
  • high intensity exercise require as much as 20 times more oxygen than an average oxygen demand of the muscle, sharply-elevated oxygen demand leads to hypoxia and accumulation of lactic acid, thereby causing fatigue of muscles.
  • vitamins and minerals include vitamin A, vitamin C, vitamin B 1 hydrochloride, vitamin B2, vitamin B6 hydrochloride, vitamin B 12, vitamin D3, folic acid, nicotinic amide, calcium phosphate, iron, magnesium oxide, zinc oxide and maltodextrin.
  • LIV 0 g/day administered, designated PSG placebo group
  • HSG half-supplemented group
  • FSG full- supplemented group
  • the thus-supplied LIV was a supplement food containing 70% LIV/capsule and having a composition ratio of isoleucine, leucine and valine in a range of 1:1.8:1.2.
  • Fig. 1 is for essential amino acids, whereas Fig. 2 is for non-essential amino acids.
  • FSG exhibited 1,402.1+177.9 watt and 1,346.9+150.0 watt, respectively, and thus there was no difference between three groups.
  • PSG exhibited 1,300.3+130.3 watt
  • HSG and FSG exhibited 1,401.1+239.2 watt and 1,445.4+161.3 watt, respectively, and the maximum anaerobic power was significantly higher in FSG (P ⁇ 0.05).
  • the maximum anaerobic power was significantly increased in FSG after supplementation of the LIV than before supplementation of the LIV (P ⁇ 0.01).
  • HSG BCAA 2.5g/day Supplement Group
  • a health supplement food utilizing branched chain amino acids in accordance with the present invention is needed by athletes and ordinary people.
  • the health supplement food can be utilized to produce a health supplement food for improving a weak constitution, by inclusion of herbal materials such as ginseng, red ginseng and Acanthopanax, and to produce a diet food or beverage and particularly a food or beverage for removing body fat around the abdomen region, by further inclusion of dietary fibers such as inulin, polydextrose and crystalline cellulose, and carnitine and hydroxy citric acid.

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  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un complément alimentaire diététique utilisant, en particulier, des acides aminés ramifiés. Elle concene plus particulièrement un complément alimentaire diététique comprenant des acides aminés à chaîne ramifiée (ci-après dénommé LIV) composé de leucine (L), d'isoleucine (I) et de valine (V), qui présente: une composition similaire à celle des acides aminés essentiels présents dans le lait d'origine naturelle, les oeufs, le soja, le boeuf et analogues; et un plus grand pouvoir de déclenchement instantané dans des conditions anaérobies, grâce à l'adjonction de L-glutamine et de taurine qui sont essentiellement requises lorsqu'une personne est exposée à un entraînement excessif, au stress ou au surmenage. L'invention concerne un complément alimentaire diététique destiné à améliorer une constitution faible et contenant des produits à base d'herbes médicinales, tels que le ginseng, le ginseng rouge et l'acanthopanax; et un aliment ou une boisson diététique comprenant en outre des fibres diététiques, tels que l'inuline, la polydextrose et la cellulose cristalline, ainsi que la carnitine et l'acide citrique hydroxy.
PCT/KR2005/000517 2004-12-10 2005-02-25 Complement alimentaire d'acides amines ramifies WO2006062273A1 (fr)

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KR1020040103923A KR100549697B1 (ko) 2004-12-10 2004-12-10 무산소 상태에서 순간적인 임팩트 파워를 증대 시키는 아미노산 건강기능식품
KR10-2004-0103923 2004-12-10

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011045810A1 (fr) 2009-08-13 2011-04-21 Zota Health Care Limited Compositions pharmaceutiques contenant de la taurine et de la race-méthionine pour le traitement de l'alcoolisme
WO2012005568A1 (fr) 2010-07-07 2012-01-12 N.V. Nutricia Composition nutritive de stimulation de synthèse de protéines musculaires
WO2013124860A1 (fr) 2012-02-23 2013-08-29 Zota Health Care Ltd Formulation revitalisante puissante
WO2015177805A1 (fr) 2014-05-19 2015-11-26 Zota Health Care Ltd Combinaison de taurine et de raceméthionine pour le traitement de maladies hépatiques
US9961932B2 (en) 2013-06-10 2018-05-08 N.V. Nutricia Muscle preservation in overweight or obese adult during weight loss program
CN111296843A (zh) * 2020-03-03 2020-06-19 上海泓商生物科技有限公司 抗疲劳、运动型益生菌
CN113080463A (zh) * 2021-04-23 2021-07-09 江苏金维氨生物工程有限公司 一种快速补充体能的粉剂
CN113475661A (zh) * 2021-07-07 2021-10-08 攀枝花学院 多功能健身速溶固体饮料及其制备方法
CN113853212A (zh) * 2019-06-03 2021-12-28 雀巢产品有限公司 恢复膳食补充剂

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2036552B1 (fr) 2006-07-05 2018-08-08 Kao Corporation Inhibiteur de la sénescence
CN112868956A (zh) * 2021-01-27 2021-06-01 中央民族大学 一种多功能运动饮料及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0949764A (ja) * 1995-08-08 1997-02-18 Toshiba Corp 注型絶縁物の非破壊検査方法
KR20030013836A (ko) * 2001-08-09 2003-02-15 주식회사 파시코 스포츠인용 보조식품

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0949764A (ja) * 1995-08-08 1997-02-18 Toshiba Corp 注型絶縁物の非破壊検査方法
KR20030013836A (ko) * 2001-08-09 2003-02-15 주식회사 파시코 스포츠인용 보조식품

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011045810A1 (fr) 2009-08-13 2011-04-21 Zota Health Care Limited Compositions pharmaceutiques contenant de la taurine et de la race-méthionine pour le traitement de l'alcoolisme
EP3120716A1 (fr) 2010-07-07 2017-01-25 N.V. Nutricia Composition nutritionnelle destinée à stimuler la synthèse des protéines musculaires
WO2012005582A1 (fr) 2010-07-07 2012-01-12 N.V. Nutricia Composition nutritionnelle destinée à stimuler la synthèse des protéines musculaires
CN103079415A (zh) * 2010-07-07 2013-05-01 N.V.努特里西阿公司 用于刺激肌肉蛋白质合成的营养组合物
WO2012005568A1 (fr) 2010-07-07 2012-01-12 N.V. Nutricia Composition nutritive de stimulation de synthèse de protéines musculaires
US10045999B2 (en) 2010-07-07 2018-08-14 N. V. Nutricia Nutritional composition for the stimulation of muscle protein synthesis
WO2013124860A1 (fr) 2012-02-23 2013-08-29 Zota Health Care Ltd Formulation revitalisante puissante
US9961932B2 (en) 2013-06-10 2018-05-08 N.V. Nutricia Muscle preservation in overweight or obese adult during weight loss program
WO2015177805A1 (fr) 2014-05-19 2015-11-26 Zota Health Care Ltd Combinaison de taurine et de raceméthionine pour le traitement de maladies hépatiques
CN113853212A (zh) * 2019-06-03 2021-12-28 雀巢产品有限公司 恢复膳食补充剂
CN111296843A (zh) * 2020-03-03 2020-06-19 上海泓商生物科技有限公司 抗疲劳、运动型益生菌
CN113080463A (zh) * 2021-04-23 2021-07-09 江苏金维氨生物工程有限公司 一种快速补充体能的粉剂
CN113475661A (zh) * 2021-07-07 2021-10-08 攀枝花学院 多功能健身速溶固体饮料及其制备方法

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